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- | Journal: Collagen crosslinking: effect on structure, mechanics and fibrosis progression. (Pubmed Central) - Apr 1, 2022
Limitations of pharmaceutical development may bedue to the lack of systemic investigationsrelated to the influence on crosslinking mechanism from micro to macro level, which are discussed in the last section. We also propose the unclarified questions regarding crosslinking mechanisms and potential challenges in crosslinking-targeted therapeutics development.
- || Clinical, Review, Journal: METABOLIC SYNDROME AND CARDIOVASCULAR DISEASES: GOING BEYOND TRADITIONAL RISK FACTORS. (Pubmed Central) - Apr 1, 2022
Its medium and long-term repercussions, however, invariably constitute a significant cause of morbidity and mortality. Implementing preventive and therapeutic measures against oxy-reductive imbalances and metaflammation states has unquestionable potential for favorable clinical outcomes in cardiovascular medicine.
- | Journal: Hyperglycemia-induced accumulation of advanced glycosylation end products in fibroblast-like synoviocytes promotes knee osteoarthritis. (Pubmed Central) - Mar 31, 2022
Inhibitors of HIF-1α, GLUT1 or AGEs receptors attenuated the effect of high glucose on chondrocyte degradation in the FLS-chondrocyte coculture system. In summary, we demonstrated that hyperglycemia caused AGEs accumulation in FLSs via the HIF-1α-GLUT1 pathway, which increases the release of inflammatory factors from FLSs, subsequently inducing chondrocyte degradation and promoting OA progression.
- | Journal: FBXO10 prevents chronic unpredictable stress-induced behavioral despair and cognitive impairment through promoting RAGE degradation. (Pubmed Central) - Mar 26, 2022
In summary, we demonstrated that hyperglycemia caused AGEs accumulation in FLSs via the HIF-1α-GLUT1 pathway, which increases the release of inflammatory factors from FLSs, subsequently inducing chondrocyte degradation and promoting OA progression. FBXO10 administration prevents CUS-induced behavioral despair, cognitive impairment, neuroinflammation, and the polarization of microglia through decreasing the accumulation of RAGE, p38 MAPK, and NF-κΒ, suggesting potential therapeutic strategies for the prevention and treatment of depression.
- || Review, Journal: Advanced Glycation End Products: A Sweet Flavor That Embitters Cardiovascular Disease. (Pubmed Central) - Mar 26, 2022
Mechanistic aspects concerning the recognition of AGEs by the advanced glycosylation end product-specific receptor (AGER) and its counterpart, the dolichyl-diphosphooligosaccharide-protein glycosyltransferase (DDOST) and soluble AGER are discussed. A special focus is offered to the AGE-elicited pathways that promote cholesterol accumulation in the arterial wall by enhanced oxidative stress, inflammation, endoplasmic reticulum stress and impairment in the reverse cholesterol transport (RCT).
- | Journal: Extracellular Vesicles from Adipose-Derived Stem Cells Promote Diabetic Wound Healing via the PI3K-AKT-mTOR-HIF-1α Signaling Pathway. (Pubmed Central) - Mar 24, 2022
A special focus is offered to the AGE-elicited pathways that promote cholesterol accumulation in the arterial wall by enhanced oxidative stress, inflammation, endoplasmic reticulum stress and impairment in the reverse cholesterol transport (RCT). Our findings indicated that hADSC-EVs accolated the healing of diabetic wounds by promoting HIF-1α-mediated angiogenesis in the PI3K-AKT-mTOR depend manner.
- || Review, Journal: Diabetes and Ischemic Stroke: An Old and New Relationship an Overview of the Close Interaction between These Diseases. (Pubmed Central) - Mar 23, 2022
Increased edema, neovascularization, and protease expression as well as altered vascular reactivity and tone may be involved and point to potential therapeutic targets. Further study is needed to fully understand this complex disease state and the breadth of its manifestation in the cerebrovasculature.
- Fructosilation products and low doses of advanced glycation end-products promotes premature cell death of cardiac cells exposed to doxorubicin via activation of NLRP3, MyD88 and p53 downregulation (ePoster station 5) - Mar 12, 2022 - Abstract #HEARTFAILURE2022HEART_FAILURE_860;
Further study is needed to fully understand this complex disease state and the breadth of its manifestation in the cerebrovasculature. These observations suggest that AGEs and fructosilation producs promotes premature cardiotoxicity of human cardiac cells exposed to doxorubicin by activation of NLRP3, Myd88-related pathways and downregulation of p53.
- | Journal: Network Pharmacology and Molecular Docking Analysis on Molecular Mechanism of Qingzi Zhitong Decoction in the Treatment of Ulcerative Colitis. (Pubmed Central) - Mar 4, 2022
In conclusion, our study suggested four potential key active components, including quercetin, were identified in QZZTD, which could interact with Akt1 and modulate the activation of the PI3K-Akt pathway. The other three pathways may also be involved in the signaling transduction induced by QZZTD in the treatment of UC.
- | New P1/2 trial, Metastases: RAGE Inhibition to Decrease Cardiotoxicity in Women With Early Breast Cancer (clinicaltrials.gov) - Feb 25, 2022
P1/2, N=48, Not yet recruiting, Sponsor: Georgetown University
- | Preclinical, Journal, IO biomarker: Curcumin improves memory deficits by inhibiting HMGB1-RAGE/TLR4-NF-κB signalling pathway in APPswe/PS1dE9 transgenic mice hippocampus. (Pubmed Central) - Feb 22, 2022
In contrast, curcumin significantly decreased GFAP-positive cells, as assessed by immunofluorescence staining. Taken together, these data indicate that oral administration of curcumin may be a promising agent to attenuate memory deterioration in AD mice, probably inhibiting the HMGB1-RAGE/TLR4-NF-κB inflammatory signalling pathway.
- | Preclinical, Journal: Natural Occurrence of Carbon Dots during In Vitro Nonenzymatic Glycosylation of Hemoglobin A0. (Pubmed Central) - Feb 15, 2022
Thus, the formation of carbon dots at physiological temperatures raises health concerns as nonenzymatic glycosylation is a physiological process in humans and the rate of which is elevated during diabetes. The Advanced Glycosylation End products are known to have a detrimental effect in diabetic patients, and the chemical similarity between the two questions the widely studied biocompatibility of carbon dots.
- | Journal: The Effects of M1/M2 Macrophages on the mRNA Expression Profile of Diabetic Glomerular Endothelial Cells. (Pubmed Central) - Feb 9, 2022
Coculturing M1/M2 macrophages and GECs treated with AGEs can affect the mRNA expression in GECs. M2 macrophages can inhibit the Braf, Fgfr2, Map3k1, Mras, and p-ERK expression in the MAPK signaling pathway, which may be related to M2 macrophages protecting GECs from damage by AGEs.
- | Preclinical, Journal: ADAM10 attenuates the development of abdominal aortic aneurysms in a mouse model. (Pubmed Central) - Jan 18, 2022
The gelatinolytic activities of MMP‑2 and MMP‑9 were quantified via gelatin zymography analysis. These results showed that ADAM10 inhibited HMGB1/RAGE/NF‑κB signaling and MMP activity in the pathogenesis of pancreatic elastase‑induced AAA, which provide insight into the molecular mechanism of AAA and suggested that ADAM10 may be a potential therapeutic target for AAA.
- | Journal: A Study of the Protective Effect of Bushen Huoxue Prescription on Cerebral Microvascular Endothelia Based on Proteomics and Bioinformatics. (Pubmed Central) - Jan 18, 2022
Further molecular biology analysis confirmed that BSHX could downregulate the expression of FoxO1/3 protein and inhibit its nuclear transfer and inhibit the expression of downstream apoptotic protein Bim and the activation of caspase, so as to play a protective role in AGE-induced bEnd.3 injury. Taken together, these findings demonstrated the role of BSHX in the management of diabetic cerebral microangiopathy and provide some insights into the proteomics-guided pharmacological mechanism study of traditional Chinese Medicine.
- || Clinical, Journal: Predictors of coronary artery calcification and its association with cardiovascular events in patients with chronic kidney disease. (Pubmed Central) - Dec 22, 2021
Moderate to severe CAC, and lower MGP levels are associated with an increased risk for CVE. Abbreviations: AGEs: Advanced glycosylation end products; CAC: Coronary artery calcification; CACS: Coronary artery calcification score; Ca: Calcium; CI: confidence interval; CKD: Chronic kidney disease; CVE: Cardiovascular events; CT: Computed tomography; ELISA: Enzyme-linked immunosorbent assay; Hb: hemoglobin; HR: Hazard ratio; hs-CRP: high-sensitivity C-reactive protein; IL-6: Interleukin 6; iPTH: Intact parathyroid hormone; Mg: Magnesium; MGP: Matrix Gla protein; NF-κB: nuclear factor-kappa gene binding; NRL: Neutrophil-lymphocyte ratio; Runx2: Runt-related transcription factor 2; RRT: Renal replacement therapy; P: Phosphorus; Scr: Serum creatinine; TNF--alpha: Tumor necrosis factor--alpha; TC: Total cholesterol; TG: Triglyceride; VSMC: vascular smooth muscle cel.
- Rage and tlr5 receptors contribute to nociception in a rat model of fibromyalgia (Virtual Only) - Dec 20, 2021 - Abstract #Neuroscience2021Neuroscience_4836;
These data suggest that activation of TLR5 and RAGE receptors have pronociceptive effects in fibromyalgia-like nociception, with a major role of the RAGE receptor. Results suggest that TLR5 and RAGE receptors contribute to the development of reserpine-induced hypersensitivity, specifically tactile allodynia, in this model of functional pain.; Grant Support: Conacyt Grant A-S1-40015
- | Journal: Mechanical Ventilation Exacerbates Poly (I:C) Induced Acute Lung Injury: Central Role for Caspase-11 and Gut-Lung Axis. (Pubmed Central) - Dec 16, 2021
The gut-lung axis resulted in activation of pulmonary non-canonical (cytosolic mediated caspase-11 activation) and canonical (caspase-1) inflammasome (NLRP3) mediated ALI in this two-hit model resulting in GSDMD sensitive alveolar capillary barrier disruption, pyroptosis (alveolar macrophages) and cytokine maturation and release (IL-1β; IL-18). Pharmacologic strategies aimed at disrupting communication between gut and lung, inhibition of inflammasomes or GSDMD in pyroptosis may be useful in ALI.
- || Biomarker, Clinical, Journal: Pilot study to investigate differences in middle molecules, oxidative stress and markers of peripheral vascular disease in patients treated by high flux haemodialysis and haemodiafiltration. (Pubmed Central) - Nov 29, 2021
In this pilot observational study, we found patients treated by HDF had lower oxidative stress as measured by IMAR, with no differences in middle molecules. Lower oxidative stress would be expected to have diverse protective effects on the cardiovascular system Although we found no differences in ABI and CAVI, future studies are required to determine whether reduced oxidative stress translates into clinically relevant differences over time.
- Charting the Proteome Landscape in Major Psychiatric Disorders: From Biomarkers to Biological Pathways to Precision Psychiatry ([VIRTUAL]) - Nov 28, 2021 - Abstract #ACNP2021ACNP_742;
Alterations in pathways related to immune-inflammation were pervasive and transdiagnostic. The immunoinflammatory response, as assessed in peripheral blood, is a shared mechanism across SZ, BD, and MDD, which might imply that the periphery is an unspecific representation of a mechanism placed in the brain and probably a secondary phenomenon to a primarily central origin; it also implies that the biological boundaries among SZ, BD, and MDD mostly do not resemble current nosological categories and need to be completely redefined by the identification of new sub-types.
- Charting the Proteome Landscape in Major Psychiatric Disorders: From Biomarkers to Biological Pathways to Precision Psychiatry (Exhibit Hall C) - Nov 28, 2021 - Abstract #ACNP2021ACNP_614;
Alterations in pathways related to immune-inflammation were pervasive and transdiagnostic. The immunoinflammatory response, as assessed in peripheral blood, is a shared mechanism across SZ, BD, and MDD, which might imply that the periphery is an unspecific representation of a mechanism placed in the brain and probably a secondary phenomenon to a primarily central origin; it also implies that the biological boundaries among SZ, BD, and MDD mostly do not resemble current nosological categories and need to be completely redefined by the identification of new sub-types.
- | Zyclara (imiquimod) / Mochida, Viatris, Bausch Health, Interleukin 22 subunit alpha receptor / Merck (MSD)
Journal: Autophagy-based unconventional secretion of HMGB1 by keratinocytes plays a pivotal role in psoriatic skin inflammation. (Pubmed Central) - Nov 21, 2021
Finally, we demonstrated that Krt14-hmgb1 mice displayed attenuated psoriatic inflammation due to the essential crosstalk between KC-specific HMGB1-associated autosecretion and γδT cells. Thus, this study uncovered a novel autophagy mechanism in psoriasis pathogenesis, and the findings imply the clinical significance of investigating and treating psoriasis.
- || Biomarker, Review, Journal: Novel molecular markers of cardiovascular disease risk in type 2 diabetes mellitus. (Pubmed Central) - Nov 21, 2021
Laboratory information provided by the level of biomarkers could make a quantitative and qualitative contribution to the clinical process of screening, prediction, prevention, diagnosis, prognosis and monitoring of cardiovascular (CV) risk linked to diabetes. This review describes the importance of specific biomarkers, with particular focus on novel ones, for stratifying and management of diabetes CV risk.
- || Review, Journal: The Impact of Glucose-Lowering Drugs on Sarcopenia in Type 2 Diabetes: Current Evidence and Underlying Mechanisms. (Pubmed Central) - Nov 16, 2021
The aim of this narrative review is to provide an update on the effects of glucose-lowering drugs on sarcopenia in individuals with T2DM, focusing on the parameters used to define sarcopenia: muscle strength (evaluated by handgrip strength), muscle quantity/quality (evaluated by appendicular lean mass or skeletal muscle mass and their indexes), and physical performance (evaluated by gait speed or short physical performance battery). Furthermore, we also describe the plausible mechanisms by which glucose-lowering drugs may impact on sarcopenia.
- | Journal: UVA Exposure Combined with Glycation of the Dermis Are Two Catalysts for Skin Aging and Promotes a Favorable Environment to the Appearance of Elastosis. (Pubmed Central) - Nov 7, 2021
Tropoelastin protein expression (elastin precursor) was also increased. In conclusion, fibroblasts in monolayers cultured with soluble pentosidine and tridimensional in vitro skin constructs exposed to the combination of AGEs and UVA promote an inflammatory state and an alteration of the dermal compartment in relation to an elastosis-like environment.
- | Journal: Metabolic syndrome and the plasma proteome: from association to causation. (Pubmed Central) - Nov 4, 2021
We reveal possible casual effects of APOE2, APOB and RET on MetS. Our results highlight protein candidates that could potentially serve as targets for prevention and therapy.
- | Journal: Epithelial-to-mesenchymal transition in neutrophilic chronic rhinosinusitis. (Pubmed Central) - Oct 30, 2021
The factors cause EMT in CRS, and the associated molecular mechanisms are related to neutrophilic inflammation. Further studies on CRS endotype and/or phenotype are needed to clarify the implication of EMT on CRS pathogenesis.
- | Journal: Radix Rehmanniae and Corni Fructus against Diabetic Nephropathy via AGE-RAGE Signaling Pathway. (Pubmed Central) - Oct 15, 2021
The results revealed the relationship between multicomponents and multitargets of RC. The administratiom of RC might remit the DM-induced renal damage through the AGE-RAGE signaling pathway to improve metabolic parameters and protect renal structure and function.
- | Preclinical, Journal: RAGE signaling pathway in Hippocampus Dentate Gyrus Involved in GLT-1 decrease Induced by Chronic Unpredictable Stress in Rats. (Pubmed Central) - Oct 1, 2021
Neither CUS nor RAGE knockdown altered GLAST protein and mRNA levels. These findings suggested that RAGE/CREB-NF-κB signaling pathway in hippocampus DG involved in modulation of GLT-1 expression, which possibly contributed to the depressive-like behavior induced by CUS.
- | Journal: Comparison between Standard Single Chamber vs Dual Chamber Low Glucose Degradation Product Peritoneal Dialysis Fluids. (Pubmed Central) - Sep 29, 2021
In our cross-sectional observational study, we were not able to show a demonstrable advantage for using low GDP dialysates over conventional glucose dialysates, in terms of biochemical profiles, residual renal function, muscle strength or tissue AGE deposition. More patients using low GDP dialysates were slower peritoneal transporters with higher ECW/TBW ratios.
- || Review, Journal: Evolution of blood-brain barrier in brain diseases and related systemic nanoscale brain-targeting drug delivery strategies. (Pubmed Central) - Sep 16, 2021
In this review, we focus on nanoscale brain-targeting drug delivery strategies designed based on BBB evolutions and related applications in various brain diseases including Alzheimer's disease, Parkinson's disease, epilepsy, stroke, traumatic brain injury and brain tumor. The advances on optimization of small molecules for BBB crossing and non-systemic administration routes (e.g., intranasal treatment) for BBB bypassing are not included in this review.
- | Journal: Advanced glycosylation end products inhibit the proliferation of bone-marrow stromal cells through activating MAPK pathway. (Pubmed Central) - Sep 5, 2021
The advances on optimization of small molecules for BBB crossing and non-systemic administration routes (e.g., intranasal treatment) for BBB bypassing are not included in this review. Advanced glycosylation end products can inhibit the proliferation of bone-marrow stromal cells through activating MAPK pathway.
- || Clinical, Journal: Comparison of skin autofluorescence, a marker of tissue advanced glycation end-products in the fistula and non-fistula arms of patients treated by hemodialysis. (Pubmed Central) - Aug 28, 2021
AVF alters blood flow in the arm, and we found that SAF measurements were lower in the arm with AVF. We suggest that SAF measurements are made in the non-AVF arm.
- | Journal, Cancer stem cells: S100 calcium-binding protein A9 from tumor-associated macrophage enhances cancer stem cell-like properties of hepatocellular carcinoma. (Pubmed Central) - Jul 28, 2021
Furthermore, we found that, after treatment with S100A9, HepG2 and MHCC-97H cells recruited more macrophages via chemokine (CC motif) ligand 2, which suggests a positive feedback between TAMs and HCC cells. Taken together, our findings reveal that TAMs could upregulate secreted protein S100A9 and enhance the stem cell-like properties of HCC cells and provide a potential therapeutic target for combating HCC.
- | Journal: RAGE signalling in obesity and diabetes: focus on the adipose tissue macrophage. (Pubmed Central) - Jul 18, 2021
We also briefly describe the phenotypes and characteristics of macrophages and focus on the role of adipose tissue macrophages (ATMs) and the regulatory mechanisms in obesity, diabetes, and other related metabolic diseases. Besides, we will also elaborate on the prospect of new strategies for treating diabetes and obesity-related metabolic diseases by inhibiting RAGE signalling and regulating ATMs recruitment and polarization.
- | gliclazide / Generic mfg.
Preclinical, Journal: How Does Glycation Affect Binding Parameters of the Albumin-Gliclazide System in the Presence of Drugs Commonly Used in Diabetes? In Vitro Spectroscopic Study. (Pubmed Central) - Jul 15, 2021
The nature of changes in the secondary structure of a protein depends on the drug used and the degree of glycation. Therefore, these interactions may have an influence on pharmacokinetic parameters.
- | Journal: Intracellular amyloid-β disrupts tight junctions of the retinal pigment epithelium via NF-κB activation. (Pubmed Central) - Jul 11, 2021
In addition, tight-junction complexes remained intact in the RPE of mice with NF-κB inhibition, although there were intracellular amyloid-β oligomers. These data suggested that NF-κB inhibition might be a therapeutic approach to prevent amyloid-β-mediated tight-junction disruption.
- || Review, Journal, IO biomarker: Role of high mobility group box 1 and its modulation by thrombomodulin/thrombin axis in neuropathic and inflammatory pain. (Pubmed Central) - Jul 7, 2021
Small molecules that directly inactivate HMGB1 or antagonize HMGB1-targeted receptors would be useful to reduce various intractable pain. Thus, HMGB1 and its receptors are considered to serve as promising targets in developing novel agents to prevent or treat pathological pain.
- | Preclinical, Journal: Effect of Different High-Fat and Advanced Glycation End-Products Diets in Obesity and Diabetes-Prone C57BL/6 Mice on Sperm Function. (Pubmed Central) - Jun 23, 2021
Our results, interestingly, showed that isthe negative effects of a diet containing AGEs on examined parameters are lessthan those in HF diets. One possible reason is detoxification through the activation of the protective glyoxalase pathway asthe result of the chronic AGEs increase in the body.
- | Journal, IO biomarker: The pathogenicity, structural and functional exploration of human HMGB1 single nucleotide polymorphisms using in silico study. (Pubmed Central) - Jun 22, 2021
The study identified potent mutations R10T (a cancer-causing somatic mutation) and F103C (a novel mutation) and these mutations either directly or indirectly hinder DNA binding activity and TLR and cytokine binding of HMGB1. These findings will help in understanding the molecular basis of these promising mutations and functional role of human HMGB1 in cancer and immunological diseases.
- | Biomarker, Journal: Role Played by Receptors for Advanced Glycosylation End Products in Corneal Endothelial Cells after HSV-1 Infection. (Pubmed Central) - Jun 22, 2021
Global transcriptional response analysis confirmed that RAGE and TLR9 were both significantly involved in type I interferon responses. We conclude that RAGE is a sensor of HSV-1 infection and provokes a type I interferon response.
- [VIRTUAL] Socioeconomic disparity in cardiovascular disease: a proteomic approach () - Jun 17, 2021 - Abstract #ESC2021ESC_57;
The range of biomarkers indicate that pathways involving inflammation (IL6, LEP, RAGE), platelet-activation (vWF, IL6, RAGE), blood pressure (REN, LEP), MAPK cascade (GDF_15, FGF21, LEP, IL6, REN, GH) and weigh (LEP) regulation contribute to the socioeconomic gradient in CVD. Further exploration is needed to identify possible candidates for intervention.
- | Journal: Role of Atypical Chemokines and Chemokine Receptors Pathways In the Pathogenesis of Copd. (Pubmed Central) - Jun 5, 2021
Antibody-based (biological) and small molecule drug (SMD)-based therapies targeting atypical chemokines and/or their receptors are mostly at the preclinical stage and their progression to clinical trials is eagerly awaited. These agents will most likely enhance our knowledge about the role of a typical chemokines in COPD pathophysiology and thereby improve COPD management.
- || progesterone / Generic mfg.
Clinical, Journal: Oral Vitamin D supplementation impacts gene expression in granulosa cells in women undergoing IVF. (Pubmed Central) - May 26, 2021
P4
Liquid chromatography tandem mass spectrometry was used to measure FF abundance of 25-hydroxyvitamin D, aldosterone, androstenedione, cortisol, cortisone, corticosterone, 11-deoxycorticosterone, 11-deoxycortisol, 21-deoxycortisol, dehydroepiandrosterone, dehydroepiandrosterone sulfate, dihydrotestosterone, oestradiol (E2), 17-OH-hydroxyprogesterone, progesterone (P4) and testosterone...There are no competing interests. EudraCT registration number 2015-004233-27.
- || Review, Journal: Endothelial Dysfunction in Diabetic Retinopathy. (Pubmed Central) - May 20, 2021
These factors promote retinal endothelial dysfunction, which results in the development of DR. In this review, we summarize the contributors in the pathophysiology of DR for a better understanding of the molecular and cellular mechanism in the development of DR with a special emphasis on retinal endothelial dysfunction.
- | Journal: Metabolomic profiling identifies a novel mechanism for heat stroke‑related acute kidney injury. (Pubmed Central) - May 8, 2021
Metabolomics indicated increased adrenic acid, docosahexaenoic acid and eicosapentaenoic acid may serve as metabolic biomarkers for AKI in HS. The findings suggested that a correlation between the HMGB1/RAGE pathway and biosynthesis of unsaturated fatty acids may contribute to the progression of HS‑related AKI.
- | Preclinical, Journal: Mechanism of advanced glycation end products inhibiting the proliferation of peripheral blood mononuclear cells and osteoblasts in rats (Pubmed Central) - Apr 28, 2021
The findings suggested that a correlation between the HMGB1/RAGE pathway and biosynthesis of unsaturated fatty acids may contribute to the progression of HS‑related AKI. AGEs inhibit the proliferation of PBMCs and OB, and the NF-κB and MAPK pathways are likely involved in regulating this process, but not the PI3K/PKB pathway.
- | Preclinical, Journal: Salidroside protects against cardiomyocyte apoptosis and ventricular remodeling by AKT/HO-1 signaling pathways in a diabetic cardiomyopathy mouse model. (Pubmed Central) - Apr 24, 2021
Salidroside protects against cardiomyocyte apoptosis and ventricular remodeling in diabetic mice. This cardio-protective effect of salidroside is dependent on AKT signaling activation.
- | Preclinical, Journal: Influences of advanced glycosylation end products on the inner blood-retinal barrier in a co-culture cell model in vitro. (Pubmed Central) - Apr 7, 2021
AGEs increased VEGF but lowered PEDF in a dose- and time-dependent manner. The intervention with AGEs led to the change of the transendothelial resistance of the RMEC layer likely caused by the increased ratio of VEGF/PEDF.
- | Preclinical, Journal: MiR-185-3p downregulates advanced glycosylation end product receptor expression and improves renal function in diabetic nephropathy mice. (Pubmed Central) - Apr 1, 2021
The intervention with AGEs led to the change of the transendothelial resistance of the RMEC layer likely caused by the increased ratio of VEGF/PEDF. MiR-185-3p inhibits AGER, downregulates AGER expression, and improves renal function in DN mice.