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- | Preclinical, Journal: Cinnamaldehyde ameliorates diabetes-induced biochemical impairments and AGEs macromolecules in a pre-clinical model of diabetic nephropathy. (Pubmed Central) - Nov 19, 2024
These findings suggest potential role of cinnamaldehyde in reversing STZ-induced diabetic nephropathic impairments; therefore, appears promising candidate for further pharmacological explorations towards diabetes-associated complications.
- | Journal: AGEs impair osteogenesis in orthodontic force-induced periodontal ligament stem cells through the KDM6B/Wnt self-reinforcing loop. (Pubmed Central) - Nov 18, 2024
This study elucidates a novel mechanism by which AGEs influence the osteogenic process and antioxidative capacity of PDLSCs through the KDM6B/Wnt self-reinforcing loop under orthodontic force. Targeting the AGE/RAGE pathway or enhancing KDM6B may enhance orthodontic treatments for diabetic patients.
- | Preclinical, Journal: Antioxidant and anti-glycation activities of Mandevilla velutina extract and effect on parasitemia levels in Trypanosoma cruzi experimental infection: in vivo, in vitro and in silico approaches. (Pubmed Central) - Nov 14, 2024
The results showed that the hydroethanolic extract of M. velutina xylopodium contains bioactive compounds including polyphenols, flavonoids and steroidal aglycones (mainly Velutinol A) of which may be responsible for the antioxidant, anti-glycation and anti-parasitic activity against T. cruzi. Trypanocidal activity of M. velutina compounds may be linked to their influence on NO synthesis during infection and/or their capacity to bind and inhibit molecules associated to virulence and survival of T. cruzi.
- | chlorogenic acid / Jiuzhang Biotech
Journal, Metastases: Phenolic compounds profile in extracts of Smilax spp., antioxidant activity, and inhibition of advanced glycation end products. (Pubmed Central) - Nov 13, 2024
To achieve this, the Smilax genus was identified via PCR, and phenolic compounds including chlorogenic acid, naringenin-6-C-glucoside, quercetin, quercetin-3-O-glucoside, and myricetin were identified using HPLC-MS/MS...These results demonstrate that Smilax spp. can inhibit AGEs, neutralize free radicals, and reduce compounds associated with antioxidant capacity.
- | Journal, Metastases: Citral: A potent inhibitor of advanced glycation end products. (Pubmed Central) - Nov 13, 2024
Additionally, the cytotoxicity assay demonstrated that the BSA-Cit adducts were non-toxic. This research indicated that Cit was a potent and safe inhibitor of AGEs.
- Protective effect of RAGE inhibitor compound A on emphysema () - Nov 5, 2024 - Abstract #APSR2024APSR_8;
These findings show that inhibiting RAGE in alveolar epithelial cells suppresses lung injury and emphysema by inhibiting oxidative stress-induced inflammation and MMPs and promoting alveolar epithelial cell proliferation. The interruption of DAMP-RAGE interaction through CA offers a promising therapeutic strategy for the alleviation of emphysema.
- || Clinical, Journal: The Effects of the AGE Inhibitor Pyridoxamine on Bone in Older Women with Type 2 Diabetes: a Randomized Clinical Trial. (Pubmed Central) - Oct 8, 2024
PM tended to increase P1NP in older T2D women, as well as increasing bone density and reducing HbA1c. Further studies are needed to investigate the potential of PM as a disease mechanism-directed approach to reduce fractures in T2D.
- | Preclinical, Journal: The AGEs/RAGE Signaling Pathway Regulates NLRP3-Mediated Neuronal Pyroptosis After MCAO Injury in Lepr-/- Obese Rats. (Pubmed Central) - Oct 7, 2024
Inhibition of AGEs/RAGE signaling pathway with FPS-ZM1 reduced the NLRP3 inflammasome-mediated neuronal pyroptosis in Lepr-/- obese rats, thereby mitigating the neuronal damage after cerebral ischemia. The AGEs/RAGE signaling pathway is involved in the exacerbation of cerebral ischemic injury in Lepr-/- obese rats via regulating NLRP3-mediated neuronal pyroptosis.
- | Journal: Lentivirus-mediated RNA interference targeting HMGB1 modulates AQP1 to reduce pain induced by chronic compression of the dorsal root ganglia. (Pubmed Central) - Oct 3, 2024
After silencing AQP1, NF-?B also decreased significantly, indicating that AQP1 is an upstream regulator of NF-?B. Lentivirus-mediated RNA interference (RNAi) silencing targeting HMGB1 may play a key role in the development of neuropathic pain in rats by regulating AQP1 expression via RAGE and ultimately activating NF-?B.
- Increased RAGE Expression in Myositis (In Person) - Sep 25, 2024 - Abstract #ACRConvergence2024ACR_Convergence_2428;
Overall, we observed increased RAGE expression in the skeletal muscle of myositis mice and human patients. These findings suggest that RAGE inhibition may be a promising strategy to dampen inflammation, improve muscle function, and ultimately enhance patient well-being.
- | Journal: THBru attenuates diabetic cardiomyopathy by inhibiting RAGE-dependent inflammation. (Pubmed Central) - Sep 24, 2024
We conclude that THBru acts as an inhibitor of RAGE, leading to inactivation of the PI3K/AKT/NF-?B pathway. This action effectively alleviates the inflammatory responses and oxidative stress in cardiomyocytes, ultimately leading to ameliorated DCM.
- | Preclinical, Journal: Geniposide ameliorates diabetic nephropathy in type 2 diabetic mice by targeting AGEs-RAGE-dependent inflammatory pathway. (Pubmed Central) - Sep 21, 2024
Geniposide effectively attenuates AGEs-induced RAGE activation by directly blocking AGEs-RAGE signal transduction, thereby mitigating inflammatory responses. These findings suggest that geniposide has potential as a high-affinity RAGE antagonist, potentially playing a crucial role in the treatment of DN.
- || Review, Journal: High Mobility Group Box Protein (HMGB1): A Potential Therapeutic Target for Diabetic Encephalopathy. (Pubmed Central) - Sep 20, 2024
Additionally, HMGB1 is reported to induce insulin resistance, further exacerbating the metabolic dysfunction associated with diabetes mellitus (DM). Thus, the present review explores the possible pathways associated with DM-induced hyperactivation of HMGB1 ultimately leading to DE.
- | Preclinical, Journal: Phytochemical, biochemical and physiological assessment of the protective effect of local Trigonella foenum graecum in rats administered a ?-cell toxicant. (Pubmed Central) - Sep 13, 2024
In vivo, 10%AFS- supplemented diet (w/w) was found to elicit a significant reduction in glycemia, TNF-?, IL-6, CRP, liver markers, lipid peroxidation (MDA) and protein carbonyl (PCO) along with improvement in reduced glutathione (GSH) amount, glutathione peroxidase (GPx), catalase (CAT) and glutathione-S-transferase (GST) activities with rejuvenation of hepatic and pancreatic micro-anatomical features. These outcomes disclosed that AFS is endowed with biologically effective components which could be decent applicant to attain the objective of glycation, oxidative stress and mitigating diabetes-related complications.
- | Journal, Metastases: Inhibition of Advanced Glycation End Products (AGEs) by Fermented Foods Using Lactic Acid Bacteria. (Pubmed Central) - Sep 1, 2024
Therefore, it is necessary to identify starter strains of LAB to produce fermented food to decrease the risk of DM and its complications. This chapter introduces the protocols that are inhibition assay of fermented food using LAB on AGEs such as N?-(carboxymethyl) arginine (CMA), N?-(carboxymethyl) lysine (CML), and fluorescent AGEs.
- Neuropharmacological Exploration: Novel chalcone based small molecules ameliorate STZ induced memory dysfunction in mice for Cognitive Enhancement (MCP Hall A) - Aug 22, 2024 - Abstract #Neuroscience2024Neuroscience_9440;
Aminoalkylchalcones had potential to improve the cognitive functions via improving cholinergic transmission and reducing oxidative stress and AGEs. Thus, these potential molecules could be taken for further studies including toxicity evaluation to develop them as anti-Alzheimer
- The glycation-lowering formulation Gly-Low improves Alzheimer (MCP Hall A) - Aug 22, 2024 - Abstract #Neuroscience2024Neuroscience_2636;
These data demonstrate that APOE genotype influences the impact of the beneficial effects of Gly-Low. The well-known importance of age and the progeroid effect of APOE4 on AD highlight the potential to use geroscience approaches in the prevention and treatment of AD.
- | Preclinical, Journal, Metastases: Role of advanced glycation end-products in age-associated kidney dysfunction in naturally aging mice. (Pubmed Central) - Aug 17, 2024
The well-known importance of age and the progeroid effect of APOE4 on AD highlight the potential to use geroscience approaches in the prevention and treatment of AD. These findings underscore the critical role of AGEs in age-related renal dysfunction and highlight the therapeutic potential of aminoguanidine in mitigating fibrosis and senescence, offering prospective avenues for combating age-associated renal ailments.
- A Clinical Study to Assess the Efficacy of a Topical Cream Containing Two Flavonoid-Rich Fruit Extracts with Rejuvenation Procedures to Improve Signs of Facial Aging (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_2846;
These findings underscore the critical role of AGEs in age-related renal dysfunction and highlight the therapeutic potential of aminoguanidine in mitigating fibrosis and senescence, offering prospective avenues for combating age-associated renal ailments. When integrated with facial rejuvenation procedures, the AGE inhibitory topical moisturizer was more effective than placebo moisturizer in improving laxity, clarity, radiance, elasticity, fine lines, and overall healthy skin appearance after 10 weeks of twice daily application in all Fitzpatrick skin types.
- | Journal: RAGE mediates hippocampal pericyte responses and neurovascular unit lesions after TBI. (Pubmed Central) - Aug 4, 2024
In contrast, mouse behavioural testing and doublecortin staining indicated that targeting the HMGB1-S100B/RAGE axis after CCI could protect neurological function by reducing pericyte-associated BBB damage. In conclusion, the present study provides experimental evidence for the strong correlation between the pericyte HMGB1-S100B/RAGE axis and NVU damage in the hippocampus at the early stage of TBI and further demonstrates that pericyte RAGE serves as an important target for the protection of neurological function after TBI.
- SP-1000 / Samaritan Pharma
COVID-19 SPIKE AND PARTICULATE MATTER CO-EXPOSURE: IN VITRO MODELING OF INFLAMMATION (Convention Center Exhibit Hall: Rapid Fire Area 1D) - Jul 31, 2024 - Abstract #CHEST2024CHEST_2929;
At SP100 and SP1000, the cells may have reached an inflammatory ceiling, with IL-6 at or greater than that of the LPS cells. PM exposure trends towards increasing IL-6 in a dose dependent manner.
- | Journal: Lindera obtusiloba Blume Alleviates Non-Alcoholic Fatty Liver Disease Promoted by N?-(carboxymethyl)lysine. (Pubmed Central) - Jul 31, 2024
LO alleviated the MAPK/NF-?B expression by attenuating CML and RAGE expression. Taken together, our results demonstrate that LO alleviates the progression of NAFLD by lowering the levels of AGEs by downregulating CML/RAGE expression.
- | Journal: Bongkrekic acid alleviates airway inflammation via breaking the mPTP/mtDAMPs/RAGE feedback loop in a steroid-insensitive asthma model. (Pubmed Central) - Jul 28, 2024
Accordingly, our study indicated that mPTP was important and BKA was efficient in alleviating inflammation in TDI-induced asthma. A positive feedback loop involving mPTP, mtDAMPs and RAGE was present in TDI-induced asthma, indicating that mPTP might serve as a potential therapeutic target for asthma.
- | azeliragon (TTP488) / Cantex Pharma
Journal: Involvement of RAGE in radiation-induced acquisition of malignant phenotypes in human glioblastoma cells. (Pubmed Central) - Jul 28, 2024
Both phenotypes were suppressed by specific inhibitors of RAGE (FPS-ZM1 and TTP488) or by knockdown of RAGE...In addition, ?-irradiation-induced phosphorylation of STAT3 was suppressed by RAGE inhibitors, and a STAT3 inhibitor suppressed ?-irradiation-induced enhancement of cell migration, indicating that STAT3 is involved in the migration enhancement downstream of RAGE. Our results suggest that HMGB1-RAGE-STAT3 signaling is involved in radiation-induced enhancement of GBM cell migration, and may contribute to GBM recurrence by promoting metastasis and invasion.
- || Review, Journal: Activation and Modulation of the AGEs-RAGE Axis: Implications for Inflammatory Pathologies and Therapeutic Interventions-A Review. (Pubmed Central) - Jul 22, 2024
This includes the development of AGEs inhibitors, RAGE antagonists, and interventions targeting upstream and downstream signaling pathways. Additionally, the early detection of AGEs levels and RAGE expression as biomarkers provides new avenues for the prevention and treatment of diabetes, atherosclerosis, and tumors.
- azeliragon (TTP488) / Cantex Pharma
Early Experience with Azeliragon, a RAGE inhibitor, in Combination with Temozolomide and Radiotherapy in Patients with Newly Diagnosed Glioblastoma: Phase Ib/II CAN-201 NDG Trial (Salamanca Auditorium - Hall 5) - Jul 16, 2024 - Abstract #ESMO2024ESMO_1810;
- resatorvid (TAK-242) / Takeda, Akaza Bioscience
S100A9 and HMGB1 regulate MDSC-mediated immunosuppression in melanoma (ePoster Self-Study 3) - Jul 11, 2024 - Abstract #ADO2024ADO_37;
S100A9 and HMGB1 convert healthy donor-derived monocytes into MDSC mainly through TLR4 signaling. Our results underscore the prognostic value of plasma S100A8/9 and suggest the potential of targeting TLR4 or S100A8/9 as a strategy to inhibit MDSC-mediated immunosuppression in melanoma.
- || Review, Journal, Metastases: Advanced Glycation End Products-Induced Alzheimer's Disease and Its Novel Therapeutic Approaches: A Comprehensive Review. (Pubmed Central) - Jul 1, 2024
Dietary and lifestyle modifications can also slow AD progression. Newer therapeutic approaches targeting AGE-related pathways are needed.
- | Journal, Metastases: Unveiling the mechanism of high sugar diet induced advanced glycosylation end products damage skin structure via extracellular matrix-receptor interaction pathway. (Pubmed Central) - Jun 19, 2024
Newer therapeutic approaches targeting AGE-related pathways are needed. High-sugar diets cause skin aging damage by inducing the accumulation of AGEs, disrupting the expression of ECM proteins and their receptors, and downregulating the ECM-receptor interaction pathway, which affects cellular behavioral functions such as cell proliferation, migration, and adhesion, as well as normal skin tissue structure.
- | Journal, Metastases: Prenylflavonoids isolated from Epimedii Herba show inhibition activity against advanced glycation end-products. (Pubmed Central) - Jun 17, 2024
As only 8 showed significant activity among these compounds, the catechol group of the B ring and the two prenyl groups attached to the flavanone skeleton were essential for activity. These data suggest that 8 could prevent the clinical complications of diabetes and age-related diseases by inhibiting AGEs.
- | Preclinical, Journal: Apigenin and baicalein ameliorate thoracic aortic structural deterioration and cognitive deficit via inhibiting AGEs/RAGE/NF-?B pathway in D-galactose-induced aging rats. (Pubmed Central) - Jun 15, 2024
Overall, apigenin and baicalein showed almost equal anti-aging efficacy. Our results provided an experimental basis for the application of apigenin and baicalein to delay the aging process.
- | Journal: Evaluation of Phytochemistry and Antidiabetic Potential of an Astragalus Species: Astragalus kurdicus Boiss. (Pubmed Central) - Jun 11, 2024
Among the measured saponins, the abundance of Astragaloside IV (27.41 ?g/mg in AKM) was the highest in all fractions. Thus, for the first time, the antidiabetic activity of A. kurdicus was evaluated from various perspectives.
- Neutrophil hyperinflammation in uncontrolled DM drives tissue destruction in human pulmonary TB (PS-25; Poster board no. 18) - May 31, 2024 - Abstract #ERS2024ERS_774;
M.tb-infected DM neutrophils had higher ROS and MMP-9 release, with RAGE inhibition suppressed ROS and MMP-8 secretion. Altogether our data show neutrophil hyperinflammation drives tissue destruction in DMTB.
- Late Breaking Abstract - A splice-switching oligonucleotide (SSO) targeting the Receptor for Advanced Glycation End-products (RAGE) attenuates lung injury in smoke and AATD associated lung disease (PS-11; Poster board no. 18) - May 31, 2024 - Abstract #ERS2024ERS_484;
In Serpina1a-e null mice (a model of alpha-1 antitrypsin deficiency), lung injury following a two-hit, two-week LPS challenge was also prevented by treatment with a RAGE SSO, preventing the decline in PEF and FEF50, and normalising airways resistance (Rn). Harnessing the splicing of RAGE represents a novel therapeutic modality for inflammatory lung diseases.
- resatorvid (TAK-242) / Takeda, Akaza Bioscience
S100A8/9 regulates MDSC-mediated immunosuppression and predicts poor response to immune checkpoint inhibitors in melanoma (East Foyer) - May 31, 2024 - Abstract #CIMT2024CIMT_231;
The immunosuppressive capacity of stimulated monocytes was assessed in the functional assays with T cells with or without TLR4 inhibitor (Resatorvid) and RAGE inhibitor (FPS-ZM1)...Blockade of TLR4 and, to a lesser extent, RAGE signaling, attenuated the suppression of T cell proliferation. In conclusion, these results highlight the prognostic importance of S100A8/9 and suggest the potential of targeting TLR4 signaling as a strategy to counteract MDSC-mediated immunosuppression in melanoma.
- | Journal, Metastases: Mirror, mirror on the wall, which phytochemicals in Clinacanthus nutans inhibits advanced glycation end products of them all? (Pubmed Central) - May 25, 2024
In conclusion, these results highlight the prognostic importance of S100A8/9 and suggest the potential of targeting TLR4 signaling as a strategy to counteract MDSC-mediated immunosuppression in melanoma. Notably, lutein content was higher in freeze-dried leaves (12.42?
- | chlorogenic acid / Jiuzhang Biotech
Preclinical, Journal: Protective effects of sugarcane polyphenol against UV-B-induced photoaging in Balb/c mouse skin: Antioxidant, anti-inflammatory, and anti-glycosylation Effects. (Pubmed Central) - May 18, 2024
Chlorogenic acid was determined to be the primary component of SP by using high-performance liquid chromatography-mass spectrometry...PRACTICAL APPLICATION: This study can provide a scientific basis for the practical application of sugarcane polyphenols. We expect that sugarcane polyphenols can be used in food and beverage products to provide flavor while combating skin aging.
- azeliragon (TTP488) / Cantex Pharma
A phase I/II open label study to assess safety and preliminary evidence of a therapeutic effect of azeliragon in patients refractory to first-line treatment of metastatic pancreatic cancer. (Hall A; Poster Bd #: 176a) - Apr 24, 2024 - Abstract #ASCO2024ASCO_3941;
P1/2
RAGE interaction with its ligands, including S100 proteins and HMGB1 released from PDAC cells, promotes PDAC invasion, metastasis, and resistance to 5 FU and Gemcitabine...Secondary endpoints include disease control, overall survival, changes in pain as determined by the Brief Pain Inventory, and changes in ECOG performance status, weight, and serum albumin. The study received regulatory approval and accrual started in June 2023.
- azeliragon (TTP488) / Cantex Pharma
Azeliragon, a RAGE inhibitor, in combination with temozolomide and radiotherapy in patients with newly diagnosed glioblastoma: Phase Ib/II CAN-201 NDG trial design. (Hall A; Poster Bd #: 391b) - Apr 24, 2024 - Abstract #ASCO2024ASCO_3201;
P1/2
The study received regulatory approval and accrual started in September 2023. As of January 2024, recruitment in dose level 1 was completed with 6 patients and 3 patients were already included in dose level 2.
- azeliragon (TTP488) / Cantex Pharma
A phase I/II study to assess safety and preliminary evidence of a therapeutic effect of azeliragon combined with stereotactic radiation therapy in patients with brain metastases (ADORATION). (Hall A; Poster Bd #: 390a) - Apr 24, 2024 - Abstract #ASCO2024ASCO_3198;
P1/2
Neurocognitive batteries, symptom inventories, and quality-of-life questionnaires will also be administered. Three participants have been enrolled in the starting cohort and are pending DLT assessment.
- Herceptin (trastuzumab) / Roche, azeliragon (TTP488) / Cantex Pharma, Perjeta (pertuzumab) / Roche
RAGE inhibition to decrease cancer therapy related cardiotoxicity in women with early breast cancer (RAGE). (Hall A; Poster Bd #: 207a) - Apr 24, 2024 - Abstract #ASCO2024ASCO_1347;
P1/2
In Cohort 4, 6 patients will receive dose dense doxorubicin and cyclophosphamide (ddAC)...As of 2/1/24, 4 patients have been enrolled, with 4 undergoing screening. At the completion of this trial, we plan a randomized trial to evaluate the role of TTP488 to decrease cardiotoxicity, cancer related cognitive decline and disease recurrence.
- | Journal: Advances in the study of microparticles in diabetic retinopathy. (Pubmed Central) - Apr 4, 2024
MP has emerged as a marker to assess the progression of DR. As a potential therapeutic target, MP also has considerable research value.
- S100A11 is a pro-inflammatory lipotoxic damage associated molecular pattern in metabolic dysfunction-associated steatohepatitis (Poster Area) - Apr 2, 2024 - Abstract #EASLILC2024EASL_ILC_1171;
We have demonstrated that hepatocyte derived S100A11 is a lipotoxic DAMP and along with Annexin A2 is significantly upregulated and enriched on lipotoxic EVs. These S100A11 enriched EVs activate RAGE signalling suggesting that in vivo hepatocyte derived EVs could mediate an intercellular signalling axis via RAGE activation on recruited macrophages.
- BLOCKAGE OF RAGE SIGNALING SUPPRESSES MALIGNANT TRANSFORMATION OF PANCREATIC DUCTAL ADENOCARCINOMA CELLS (Hall A) - Mar 14, 2024 - Abstract #DDW2024DDW_7177;
Furthermore we also observed a reduction in the number of CD31-positive endothelial cells alongside a reduction in inflammatory S100B expression following inhRAGE treatment in resected tumor specimens. [Conclusion]Treatment with inhRAGE treatment could be a novel remedy for the malignant transformation of PDAC.
- IDENTIFYING CAUSAL LINKS BETWEEN PLASMA PROTEOMICS AND INFLAMMATORY BOWEL DISEASES (IBD) VIA INTEGRATION OF UK BIOBANK (UKBB) PQTL DATASET AND IBD GWAS (206 - Walter E. Washington Convention Center) - Mar 14, 2024 - Abstract #DDW2024DDW_2426;
Novel causal proteins were also indicated which might lead to new biomarkers and potential therapeutic targets. Further analyses, including colocalization analysis, network analysis and integration with eQTL datasets and additional IBD associated loci are in progress.
- | Preclinical, Journal: Reduced SV2A and GABAA receptor levels in the brains of type 2 diabetic rats revealed by [18F]SDM-8 and [18F]flumazenil PET. (Pubmed Central) - Mar 4, 2024
Further analyses, including colocalization analysis, network analysis and integration with eQTL datasets and additional IBD associated loci are in progress. These findings provide in vivo evidence for regional reductions in SV2A and GABAA receptor levels in the brains of aged T2DM ZDF rats.
- Transcriptomic Heterogeneity of the Distal Epithelium in IPF Lung: Rethinking the Order of Events (San Diego Convention Center, Room 31A-C (Upper Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_3196;
Our study implies that within relatively normal tissue architecture, the distal epithelium in IPF apices is not yet dysregulated. The decline in AGER transcripts in IPF lungs correlated with histological loss of normal architecture and taken together, suggests that epithelial dysfunction occurs after fibrosis has already started.
- | Journal: Lysozyme amyloid fibril-chitosan double network hydrogel: Preparation, characterization, and application on inhibition of N?-(carboxyethyl)lysine. (Pubmed Central) - Feb 11, 2024
The quality and palatability of beef patties were improved. These findings suggest that DN shows great potential as an application that may be utilized to deliver active substances aimed at inhibiting CML in the meat processing industry.
- || Review, Journal: Urine-derived stem cell therapy for diabetes mellitus and its complications: progress and challenges. (Pubmed Central) - Feb 8, 2024
This review outlines the biological properties of USCs and the research progress and current limitations of their role in DM and related complications. In summary, USCs have shown good versatility in treating hyperglycemia-impaired target organs in preclinical models, and many challenges remain in translating USC therapies to the clinic.
- | Preclinical, Journal: Differential Modulation of Mouse Intestinal Organoids with Fecal Luminal Factors from Obese, Allergic, Asthmatic Children. (Pubmed Central) - Jan 27, 2024
The intestinal content of asthmatic obese children differentially induced the expression of inflammatory and mitochondrial response genes (Tnf-tumor necrosis factor, Cd14, Muc13-mucin 13, Tff2-Trefoil factor 2 and Tff3, Cldn1-claudin 1 and 5, Reg3g-regenerating family member 3 gamma, mt-Nd1-NADH dehydrogenase 1 and 6, and mt-Cyb-mitochondrial cytochrome b) via the RAGE-advanced glycosylation end product-specific receptor, NF-?B-nuclear factor kappa b and AKT kinase signal transduction pathways. Fecal homogenates from asthmatic normal-weight and obese children induce a differential phenotype in intestinal organoids, in which the presence of obesity plays a major role.