Angiopoietin 2 inhib 
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  • ||||||||||  Journal:  The mechanosensory channel PIEZO1 functions upstream of angiopoietin/TIE/FOXO1 signaling in lymphatic development. (Pubmed Central) -  May 15, 2024   
    These data establish a functional network between lymphedema-associated genes and provide what we believe to be the first molecular mechanism bridging channel function with vascular signaling and intracellular events culminating in transcriptional regulation of genes expressed in LECs. Our study provides insights into the regulation of lymphatic function and molecular pathways involved in human disease.
  • ||||||||||  Vabysmo (faricimab-svoa) / Roche, Lucentis (ranibizumab) / Roche, Novartis
    Journal, HEOR:  Pharmacoeconomic analysis of anti-angiogenic drugs for diabetic macular edema (Pubmed Central) -  May 14, 2024   
    Early detection of these markers can assist in the clinical diagnosis and guide the appropriate use of antibiotics. The use of faricimab is a cost-effective approach to treatment of adult patients with DME in Russia.
  • ||||||||||  Jardiance (empagliflozin) / Eli Lilly, Boehringer Ingelheim
    Journal:  Empagliflozin inhibits increased Na influx in atrial cardiomyocytes of patients with HFpEF. (Pubmed Central) -  May 10, 2024   
    We show for the first time increased Na influx in human atrial cardiomyocytes from HFpEF patients, partly due to increased late INa and enhanced NHE1-mediated Na influx. Empagliflozin inhibits Na influx and late INa, which could contribute to antiarrhythmic effects in patients with HFpEF.
  • ||||||||||  Journal:  CD151 Maintains Endolysosomal Protein Quality to Inhibit Vascular Inflammation. (Pubmed Central) -  May 9, 2024   
    Also, our study conceptualizes that balance between degradation and discharge of proteins in endothelial cells determines vascular information. Thus, the IFITM3/V-ATPase-tetraspanin-VCP/p97 complexes on endolysosome, as a protein quality control and inflammation-inhibitory machinery, could be beneficial for therapeutic intervention against vascular inflammation.
  • ||||||||||  Radiolabeled hyaluronic acid (HA) fragments for lymphatic imaging () -  May 8, 2024 - Abstract #SNMMI2024SNMMI_1294;    
    Upon intradermal administration, radioiodinated HA fragments demonstrate rapid accumulation in the lymph nodes compared to the slow uptake of 99mTc-sulfur colloid. 125I-HA35, 125I-HA60, and 125I-HA200 imaging are capable of detecting lymphatic abnormalities induced by Ang2 deficiency.
  • ||||||||||  Journal:  Preventive effects of vasohibin-2-targeting peptide vaccine for diabetic nephropathy. (Pubmed Central) -  May 2, 2024   
    The preventive effects of vaccination on glomerular injury were also confirmed in db/db mice. Taken together, the results of this study suggest that the VASH2-targeting peptide vaccine may prevent diabetic glomerular injury in mice by inhibiting Angpt2-mediated microinflammation.
  • ||||||||||  Vabysmo (faricimab-svoa) / Roche
    Review, Journal:  Global experience of faricimab in clinical settings - a review. (Pubmed Central) -  Apr 29, 2024   
    The clinical experience with faricimab to date has the potential to provide a stable visual outcome with reduced treatment burden in cases that are resistant to other approved anti-VEGF agents. There are no major safety concerns based on this data analysis.
  • ||||||||||  Journal:  Angiopoietin-2 associates with poor prognosis in Moyamoya angiopathy. (Pubmed Central) -  Apr 24, 2024   
    Our results pointed out Ang-2 as a reliable biomarker mirroring arterial steno-occlusion and vascular instability of MA in CSF and blood, providing a candidate factor for patient stratification. This pilot study may pave the way to the validation of a biomarker to identify progressive MA patients deserving a specific treatment path.
  • ||||||||||  Observational data, Journal:  Endothelial and inflammatory pathophysiology in dengue shock: New insights from a prospective cohort study in Vietnam. (Pubmed Central) -  Apr 18, 2024   
    All 4 glycocalyx biomarkers were positively associated with SOFA score, but only syndecan-1 was associated with ICU admission (OR 2.02, p<0.001) and mortality (OR 6.51, p<0.001). This study highlights the central role of hyperinflammation in determining outcomes from DS; the data suggest that anti-IL-1 and anti-IL-6 immune modulators and Tie2 agonists may be considered as candidates for therapeutic trials in severe dengue.
  • ||||||||||  salinomycin (HSB-1216) / Hillstream BioPharma
    Review, Journal:  Selected markers of ovarian cancer and their relation to targeted therapy (Review). (Pubmed Central) -  Apr 17, 2024   
    Drugs affecting cancer stem cells (CSCs) in OC, such as metformin and salinomycin, as well as inhibitors of CSCs markers aldehyde dehydrogenase 1 (with the drug ATRA) and the transcription factor Nanog homeobox (microRNA) are also discussed. A new approach to prevention and possible therapies under investigation such as development of vaccines containing a subpopulation of CD117(+) and CD44(+) stem cells with a promising option for use in women with OC was described.
  • ||||||||||  Biomarker, Journal:  Biomarkers to Predict Improvement of Left Ventricular Ejection Fraction after Atrial Fibrillation Ablation. (Pubmed Central) -  Apr 13, 2024   
    Only ANG2 and GDF15 remained significantly associated with LVEF recovery after adjustment for age, sex and Antwerp score and significantly improved the accuracy of the Antwerp score predictions (p<0.001). The AUC of the Antwerp score in the outcome prediction improved from 0.75 (95% CI 0.67-0.83) to 0.78 (95% CI 0.70-0.86) A biomarker panel (ANG2, GDF15) significantly improved the accuracy of the Antwerp Score.
  • ||||||||||  Suglat (ipragliflozin) / EMD Serono, Kotobuki, Astellas, Lusefi (luseogliflozin) / Taisho
    Journal:  The Early Pathogenesis of Diabetic Retinopathy and Its Attenuation by Sodium-Glucose Transporter 2 Inhibitors. (Pubmed Central) -  Apr 12, 2024   
    In vitro study, both inhibitors attenuated the lipopolysaccharide-induced activation of primary microglia, along with morphological changes toward an inactive form, suggesting the direct inhibitory effect of SGLT2 inhibitors on microglia. In summary, SGLT2i may directly prevent early pathogenic mechanisms, thereby potentially playing a role in preventing DR.
  • ||||||||||  Vabysmo (faricimab-svoa) / Roche
    Journal:  Short-term outcomes of intravitreal faricimab for refractory neovascular age-related macular degeneration. (Pubmed Central) -  Apr 12, 2024   
    In summary, SGLT2i may directly prevent early pathogenic mechanisms, thereby potentially playing a role in preventing DR. In the short term, IVF led to a significant decrease in CMT as well as a significant improvement of BCVA and thus appears to be an effective treatment option for previously treated refractory nAMD without relevant adverse effects.
  • ||||||||||  Journal:  Early prediction and prevention of infected pancreatic necrosis. (Pubmed Central) -  Apr 9, 2024   
    In this editorial, we summarize evidence concerning early prediction and prevention of IPN, providing insights into future practice and study design. A more homogeneous patient population with reliable risk-stratification tools may help find effective treatments to reduce the risk of IPN, thereby achieving individualized treatment.
  • ||||||||||  sirolimus / Generic mfg., acetylcysteine solution / Generic mfg.
    Journal:  Research progress on mechanism of follicle injury after frozen ovarian tissue transplantation and protective strategies. (Pubmed Central) -  Apr 2, 2024   
    Mortality markers overlapped with markers associated with persistent MODS, rather than persistent ARDS. For example, melatonin, N-acetylcysteine, erythropoietin or other antioxidants are used to reduce oxidative stress; mesenchymal stem cells derived from different tissues, basic fibroblast growth factor, vascular endothelial growth factor, angiopoietin 2 and gonadotropin are used to promote revascularization; anti-M
  • ||||||||||  Journal:  The role of proangiogenic cytokines in predicting sepsis in febrile neutropenic children with cancer. (Pubmed Central) -  Mar 29, 2024   
    In conclusion, our findings demonstrate that macrophages are an important component of the perivascular environment in CM suggesting they may contribute to the CM formation and SWS disease progression. Our results reveal that Ang-2 and Ang-2/Ang-1 were higher in the sepsis group and Ang-2 might be a biomarker to indicate the risk of sepsis in patients with FN and/or cancer.
  • ||||||||||  Discovery of Novel Proteins Binding to HIV Reverse Transcriptase (Exhibit Hall F1; Poster Board Number: B893) -  Mar 29, 2024 - Abstract #IMMUNOLOGY2024IMMUNOLOGY_2275;    
    While this might seem unremarkable, these unbinding proteins could potentially serve as negative controls in laboratory experiments, aiding in the comparison with binding proteins.To unveil the latent potential of these novel proteins, further exploration is imperative. It's important to note that referring to them as "inhibitors" requires substantiation through laboratory experimentation and accompanying data, depicting the inhibition phenomenon.
  • ||||||||||  Preclinical, Journal:  Electroacupuncture Promotes Angiogenesis in Mice with Cerebral Ischemia by Inhibiting miR-7. (Pubmed Central) -  Mar 27, 2024   
    It's important to note that referring to them as "inhibitors" requires substantiation through laboratory experimentation and accompanying data, depicting the inhibition phenomenon. EA could promote angiogenesis in MCAO mice likely by inhibiting the expression of miR-7 and relieving inhibition of downstream target genes KLF4/VEGF and ANG-2.
  • ||||||||||  Journal:  How we use angiopoietin-2 in the diagnosis and management of vascular anomalies. (Pubmed Central) -  Mar 25, 2024   
    Angiopoietin-2, a circulating blood angiogenic factor, is highly elevated in patients with kaposiform hemangioendothelioma with Kasabach-Merritt phenomenon and kaposiform lymphangiomatosis. Here, we describe our clinical experience using serum angiopoietin-2 as a biomarker for diagnosis and monitoring response to treatment.
  • ||||||||||  FGF23-Mediated Hypertension via Augmented Calcium Entry in Vascular Smooth Muscle Cells (T6) -  Mar 23, 2024 - Abstract #ERAEDTA2024ERA_EDTA_2301;    
    This effect is mediated by FGFR1-3 receptors, Erk1/2 phosphorylation, and the upregulation of related protein to cell contraction such as SERCA2a, PKD1 or AGTR1. These modifications could be responsible of FGF23-associated hypertension in the experimental model.
  • ||||||||||  Journal:  Decreased vascular reactivity associated with increased IL-8 in 6-month-old infants of mothers with pre-eclampsia. (Pubmed Central) -  Mar 21, 2024   
    These findings provide insights into the proteomic response to acute intense exercise, provide mechanistic insights into the pathophysiology behind AF in athletes, and identify targets for future study and validation. At 6 months of age, infants born to mothers with Pre-E had impaired vascular reactivity and higher IL-8 and Ang-2, but similar blood pressure and microvessel density compared to infants born to non-Pre-E mothers.
  • ||||||||||  Journal:  CPAP may promote an endothelial inflammatory milieu in sleep apnoea after coronary revascularization. (Pubmed Central) -  Mar 18, 2024   
    At 6 months of age, infants born to mothers with Pre-E had impaired vascular reactivity and higher IL-8 and Ang-2, but similar blood pressure and microvessel density compared to infants born to non-Pre-E mothers. Greater CPAP levels increase proinflammatory, lung distension-responsive angiopoietin-2 and reduce cardioprotective angiogenic factor VEGF-A compared to usual care, which may counteract the expected cardiovascular benefits of treating OSA.
  • ||||||||||  Vabysmo (faricimab-svoa) / Roche, Avastin (bevacizumab) / Roche, Eylea (aflibercept intravitreal) / Bayer, Regeneron
    DOME-SHAPED MACULA WITH SEROUS MACULAR DETACHMENT CASE REPORT () -  Mar 18, 2024 - Abstract #COPHyEU2024COPHY_EU_237;    
    Two intravitreal Bevacizumab injections and half-dose photodynamic therapy were given...For the left eye, a course of 3x Aflibercept intravitreal injections was performed, micropulse laser, laser photocoagulation of a potential leaking point according to fluorescin angiography (FAG) data, and injection of intravitreal Faricimab...Conclusions DSM with SMD remains a challenging entity with insignificant results in most of the treatment modalities. New treatment options, such as dual-action anti-VEGF and anti-Ang-2 agents, might be a viable treatment alternative that requires further studies.