- |||||||||| salinomycin (HSB-1216) / Hillstream BioPharma
Review, Journal: Selected markers of ovarian cancer and their relation to targeted therapy (Review). (Pubmed Central) - Apr 17, 2024
Drugs affecting cancer stem cells (CSCs) in OC, such as metformin and salinomycin, as well as inhibitors of CSCs markers aldehyde dehydrogenase 1 (with the drug ATRA) and the transcription factor Nanog homeobox (microRNA) are also discussed. A new approach to prevention and possible therapies under investigation such as development of vaccines containing a subpopulation of CD117(+) and CD44(+) stem cells with a promising option for use in women with OC was described.
- |||||||||| Biomarker, Journal: Biomarkers to Predict Improvement of Left Ventricular Ejection Fraction after Atrial Fibrillation Ablation. (Pubmed Central) - Apr 13, 2024
Only ANG2 and GDF15 remained significantly associated with LVEF recovery after adjustment for age, sex and Antwerp score and significantly improved the accuracy of the Antwerp score predictions (p<0.001). The AUC of the Antwerp score in the outcome prediction improved from 0.75 (95% CI 0.67-0.83) to 0.78 (95% CI 0.70-0.86) A biomarker panel (ANG2, GDF15) significantly improved the accuracy of the Antwerp Score.
- |||||||||| Suglat (ipragliflozin) / EMD Serono, Kotobuki, Astellas, Lusefi (luseogliflozin) / Taisho
Journal: The Early Pathogenesis of Diabetic Retinopathy and Its Attenuation by Sodium-Glucose Transporter 2 Inhibitors. (Pubmed Central) - Apr 12, 2024
In vitro study, both inhibitors attenuated the lipopolysaccharide-induced activation of primary microglia, along with morphological changes toward an inactive form, suggesting the direct inhibitory effect of SGLT2 inhibitors on microglia. In summary, SGLT2i may directly prevent early pathogenic mechanisms, thereby potentially playing a role in preventing DR.
- |||||||||| Vabysmo (faricimab-svoa) / Roche
Journal: Short-term outcomes of intravitreal faricimab for refractory neovascular age-related macular degeneration. (Pubmed Central) - Apr 12, 2024
In summary, SGLT2i may directly prevent early pathogenic mechanisms, thereby potentially playing a role in preventing DR. In the short term, IVF led to a significant decrease in CMT as well as a significant improvement of BCVA and thus appears to be an effective treatment option for previously treated refractory nAMD without relevant adverse effects.
- |||||||||| Journal: Early prediction and prevention of infected pancreatic necrosis. (Pubmed Central) - Apr 9, 2024
In this editorial, we summarize evidence concerning early prediction and prevention of IPN, providing insights into future practice and study design. A more homogeneous patient population with reliable risk-stratification tools may help find effective treatments to reduce the risk of IPN, thereby achieving individualized treatment.
- |||||||||| sirolimus / Generic mfg., acetylcysteine solution / Generic mfg.
Journal: Research progress on mechanism of follicle injury after frozen ovarian tissue transplantation and protective strategies. (Pubmed Central) - Apr 2, 2024
Mortality markers overlapped with markers associated with persistent MODS, rather than persistent ARDS. For example, melatonin, N-acetylcysteine, erythropoietin or other antioxidants are used to reduce oxidative stress; mesenchymal stem cells derived from different tissues, basic fibroblast growth factor, vascular endothelial growth factor, angiopoietin 2 and gonadotropin are used to promote revascularization; anti-M
- |||||||||| Journal: CD151 Maintains Endolysosomal Protein Quality to Inhibit Vascular Inflammation. (Pubmed Central) - Apr 1, 2024
Also, our study conceptualizes that balance between degradation and discharge of proteins in endothelial cells determines vascular information. Thus, the IFITM3/V-ATPase-tetraspanin-VCP/p97 complexes on endolysosome, as a protein quality control and inflammation-inhibitory machinery, could be beneficial for therapeutic intervention against vascular inflammation.
- |||||||||| Journal: The role of proangiogenic cytokines in predicting sepsis in febrile neutropenic children with cancer. (Pubmed Central) - Mar 29, 2024
In conclusion, our findings demonstrate that macrophages are an important component of the perivascular environment in CM suggesting they may contribute to the CM formation and SWS disease progression. Our results reveal that Ang-2 and Ang-2/Ang-1 were higher in the sepsis group and Ang-2 might be a biomarker to indicate the risk of sepsis in patients with FN and/or cancer.
- |||||||||| Vabysmo (faricimab-svoa) / Roche
Review, Journal: Global experience of faricimab in clinical settings - a review. (Pubmed Central) - Mar 29, 2024
The clinical experience with faricimab to date has the potential to provide a stable visual outcome with reduced treatment burden in cases that are resistant to other approved anti-VEGF agents. There are no major safety concerns based on this data analysis.
- |||||||||| Discovery of Novel Proteins Binding to HIV Reverse Transcriptase (Exhibit Hall F1; Posterboard Number: 893) - Mar 29, 2024 - Abstract #IMMUNOLOGY2024IMMUNOLOGY_2275;
While this might seem unremarkable, these unbinding proteins could potentially serve as negative controls in laboratory experiments, aiding in the comparison with binding proteins.To unveil the latent potential of these novel proteins, further exploration is imperative. It's important to note that referring to them as "inhibitors" requires substantiation through laboratory experimentation and accompanying data, depicting the inhibition phenomenon.
- |||||||||| Journal: Endothelial and inflammatory pathophysiology in dengue shock: New insights from a prospective cohort study in Vietnam. (Pubmed Central) - Mar 27, 2024
All 4 glycocalyx biomarkers were positively associated with SOFA score, but only syndecan-1 was associated with ICU admission (OR 2.02, p<0.001) and mortality (OR 6.51, p<0.001). This study highlights the central role of hyperinflammation in determining outcomes from DS; the data suggest that anti-IL-1 and anti-IL-6 immune modulators and Tie2 agonists may be considered as candidates for therapeutic trials in severe dengue.
- |||||||||| Preclinical, Journal: Electroacupuncture Promotes Angiogenesis in Mice with Cerebral Ischemia by Inhibiting miR-7. (Pubmed Central) - Mar 27, 2024
This study highlights the central role of hyperinflammation in determining outcomes from DS; the data suggest that anti-IL-1 and anti-IL-6 immune modulators and Tie2 agonists may be considered as candidates for therapeutic trials in severe dengue. EA could promote angiogenesis in MCAO mice likely by inhibiting the expression of miR-7 and relieving inhibition of downstream target genes KLF4/VEGF and ANG-2.
- |||||||||| Journal: How we use angiopoietin-2 in the diagnosis and management of vascular anomalies. (Pubmed Central) - Mar 25, 2024
Angiopoietin-2, a circulating blood angiogenic factor, is highly elevated in patients with kaposiform hemangioendothelioma with Kasabach-Merritt phenomenon and kaposiform lymphangiomatosis. Here, we describe our clinical experience using serum angiopoietin-2 as a biomarker for diagnosis and monitoring response to treatment.
- |||||||||| Journal: Decreased vascular reactivity associated with increased IL-8 in 6-month-old infants of mothers with pre-eclampsia. (Pubmed Central) - Mar 21, 2024
These findings provide insights into the proteomic response to acute intense exercise, provide mechanistic insights into the pathophysiology behind AF in athletes, and identify targets for future study and validation. At 6 months of age, infants born to mothers with Pre-E had impaired vascular reactivity and higher IL-8 and Ang-2, but similar blood pressure and microvessel density compared to infants born to non-Pre-E mothers.
- |||||||||| Journal: CPAP may promote an endothelial inflammatory milieu in sleep apnoea after coronary revascularization. (Pubmed Central) - Mar 18, 2024
At 6 months of age, infants born to mothers with Pre-E had impaired vascular reactivity and higher IL-8 and Ang-2, but similar blood pressure and microvessel density compared to infants born to non-Pre-E mothers. Greater CPAP levels increase proinflammatory, lung distension-responsive angiopoietin-2 and reduce cardioprotective angiogenic factor VEGF-A compared to usual care, which may counteract the expected cardiovascular benefits of treating OSA.
- |||||||||| Vabysmo (faricimab-svoa) / Roche, Avastin (bevacizumab) / Roche, Eylea (aflibercept intravitreal) / Bayer, Regeneron
DOME-SHAPED MACULA WITH SEROUS MACULAR DETACHMENT CASE REPORT () - Mar 18, 2024 - Abstract #COPHyEU2024COPHY_EU_237;
Two intravitreal Bevacizumab injections and half-dose photodynamic therapy were given...For the left eye, a course of 3x Aflibercept intravitreal injections was performed, micropulse laser, laser photocoagulation of a potential leaking point according to fluorescin angiography (FAG) data, and injection of intravitreal Faricimab...Conclusions DSM with SMD remains a challenging entity with insignificant results in most of the treatment modalities. New treatment options, such as dual-action anti-VEGF and anti-Ang-2 agents, might be a viable treatment alternative that requires further studies.
- |||||||||| Journal: A new look at angiogenesis inhibition of geniposide in experimental arthritis by blocking angiopoietin-2 exocytosis. (Pubmed Central) - Mar 14, 2024
GE dose-dependently weakened S1P/S1PR1/3/PLC?3/Ca signal axis activation, Ang-2 exocytosis and angiogenesis in HUVECs (p?<?0.05, p?<?0.01). Overall, these findings revealed that angiogenesis inhibition of GE was partly attributed to the intervention of Ang-2 exocytosis through negatively modulating the S1P/S1PR1/3/PLC?3/Ca signal axis, providing a novel strategy for rheumatoid arthritis anti-angiogenic therapy.
- |||||||||| Vabysmo (faricimab-svoa) / Roche
Journal, Adverse events: Rates of Ocular Adverse Events Following Intravitreal Faricimab Injections. (Pubmed Central) - Mar 8, 2024
Future research may benefit from considering other tools to predict and prevent development of ARDS in this population. Based on one-year experience with faricimab in a large retina-only practice, our study identified a 1.9% rate of serious ocular adverse events and a similarly low rate of intraocular inflammation that was comparable to clinical trials.
- |||||||||| KIDNEY INJURY IN SNAKEBITE PATIENTES WHIT AND WHITOUT SPOONTANEOUS BLEEDING AND IMPLICATIONS OF ANTIVENOM THERAPY (SUN-282; Exhibition Hall and Main Foyer) - Mar 8, 2024 - Abstract #ISNWCN2024ISN_WCN_1708;
Based on one-year experience with faricimab in a large retina-only practice, our study identified a 1.9% rate of serious ocular adverse events and a similarly low rate of intraocular inflammation that was comparable to clinical trials. Bothrops envenenomation caused important tubular kidney injury that remains installed even after antivenom use in the context of severe coagulation disturbances.
- |||||||||| ENDOTHELIAL BIOMARKERS AS PREDICTORS OF MORTALITY FOLLOWING SARS-COV-2 INFECTION IN SOLID ORGAN TRANSPLANT RECIPIENTS (MON-254; Exhibition Hall and Main Foyer) - Mar 8, 2024 - Abstract #ISNWCN2024ISN_WCN_1552;
Bothrops envenenomation caused important tubular kidney injury that remains installed even after antivenom use in the context of severe coagulation disturbances. Endothelial damage are associated with Covid-19 mortality in SOT recipients, as demonstrated in immunocompetent individuals, suggesting that immunosuppression does not significantly modulate endothelial dysfunction caused by the infection.
- |||||||||| PULMONARY FUNCTIONALITY AND ENDOTHELIAL DAMAGE AMONG PATIENTS ON KIDNEY REPLACEMENT THERAPIES (SAT-243; Exhibition Hall and Main Foyer) - Mar 8, 2024 - Abstract #ISNWCN2024ISN_WCN_1518;
Endothelial damage are associated with Covid-19 mortality in SOT recipients, as demonstrated in immunocompetent individuals, suggesting that immunosuppression does not significantly modulate endothelial dysfunction caused by the infection. Despite better endothelial function, KT was not associated with superior pulmonary functionality, suggesting multifactorial pathophysiology for lung impairment.
- |||||||||| CORRELATION OF KLOTHO PROTEIN, BIOMARKERS OF ENDOTHELIAL DAMAGE AND COGNITIVE IMPAIRMENT IN PATIENTS WITH CHRONIC KIDNEY DISEASE (SUN-028; Exhibition Hall and Main Foyer) - Mar 8, 2024 - Abstract #ISNWCN2024ISN_WCN_800;
There was an inverse correlation between decreased Klotho levels and an increase in the endothelial damage marker VCAM-1 in moderate/severe CKD patients. Another relevant finding of this study was that reduced serum levels of Klotho are associated with worse results in different neurocognitive tests in patients with CKD without a previous clinical diagnosis of cerebrovascular disease, with worse results being seen in different cognitive domains such as memory, attention and executive functions.
- |||||||||| Synthetic disulfide derivative of vitamin B1, fursultiamine, prevents VEGF-induced angiogenesis (Section 6) - Mar 5, 2024 - Abstract #AACR2024AACR_8568;
Further, fursultiamine also regulated the VEGF-induced expression of various angiogenic markers such as VEGF, PDGF, EGF, Ang1, Ang2, angiogenin, and FGF, inflammatory markers such IL-1b, GM-CSF, TGF-b, MMPs, and others such as TIMPs, PTX3 and CF-III. Based on our in vitro data, we suggest that fursultiamine could prevent VEGF-induced angiogenesis, and this compound as a potent anti-angiogenic agent that could prevent cancer growth and metastasis.
- |||||||||| temozolomide / Generic mfg.
Journal: Angiopep-2-Functionalized Lipid Cubosomes for Blood-Brain Barrier Crossing and Glioblastoma Treatment. (Pubmed Central) - Feb 28, 2024
In this study, we developed angiopep-2 (Ang2)-functionalized lipid cubosomes loaded with cisplatin (CDDP) and temozolomide (TMZ) for crossing the BBB and providing targeted glioblastoma therapy...Moreover, CDDP-loaded Ang2-functionalized cubosomes presented an enhanced toxic effect on U87 spheroids. These findings suggest that the developed Ang2-cubosomes are prospective for improved BBB crossing and enhanced delivery of therapeutics to glioblastoma and are worth pursuing further as a potential application of nanomedicine for GBM treatment.
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