 |
0 Companies | 0 Products |
|
|
0 Products | |
0 Diseases | |
0 Trials |  |
0 News |  |
| 12345» |
- | setanaxib (GKT831) / Calliditas
Journal: LRRC8A drives NADPH oxidase-mediated mitochondrial dysfunction and inflammation in allergic rhinitis. (Pubmed Central) - Nov 18, 2024
It also activates NF-?B, ultimately leading to nasal mucosal epithelial inflammation. LRRC8A may be a potential target for the treatment of AR.
- | Journal: Multi-omics analysis identified IL-4-induced IL1RL1high eosinophils characterized by prominent cysteinyl leukotriene metabolism. (Pubmed Central) - Nov 13, 2024
IL-4 induces the proallergic phenotype of IL1RL1high eosinophils, with prominent cysteinyl leukotriene metabolism via STAT6. These cellular changes represent potential therapeutic targets for chronic rhinosinusitis and eosinophilic asthma.
- dexamethasone / Generic mfg.
The function of neutrophil extracellular traps (NETs) in airway epithelial cells in the murine model of steroid-resistant asthma () - Nov 5, 2024 - Abstract #APSR2024APSR_132;
BALB/c mice were challenged intranasally with ovalbumine (OVA) alone or in combination with NETs with or without dexamethasone (DEX)... NETs can contribute to being resistant to steroids in airway epithelial cells and murine asthma models.
- | Journal: Type 2 Cytokine-Dependent Skin Barrier Regulation in Personalized 2-Dimensional and 3-Dimensional Skin Models of Atopic Dermatitis: A Pilot Study. (Pubmed Central) - Oct 10, 2024
Histologically, IL-13 alone and in combination with IL-4 increased epidermal spongiosis, a histological hallmark of AD skin. Taken together, our pilot study suggests that hair follicle-derived KCs from patients with AD represent a useful model system to study AD-related inflammation in a personalized in
- | Journal: A lentiviral toolkit to monitor airway epithelial cell differentiation using bioluminescence. (Pubmed Central) - Oct 4, 2024
Transduced cells also responded appropriately to stimulation with interleukin 13 (IL-13; to increase mucosecretory differentiation and mucus production) and IL-6 (to increase ciliated cell differentiation). These constructs represent a new tool for monitoring airway epithelial cell differentiation in primary epithelial and/or induced pluripotent stem cell (iPSC) cell cultures.
- | Journal: Role of basal cells in nasal polyp epithelium in the pathophysiology of eosinophilic chronic rhinosinusitis (eCRS). (Pubmed Central) - Sep 21, 2024
These constructs represent a new tool for monitoring airway epithelial cell differentiation in primary epithelial and/or induced pluripotent stem cell (iPSC) cell cultures. Type 2 cytokines IL-4 and IL-13 induce basal cell hyperplasia, and basal cells exacerbate type 2 inflammation by producing TSLP in nasal polyp of eCRS.
- | omeprazole / Generic mfg.
Journal: Proton pump inhibitors modulate esophageal epithelial barrier function and crosstalk with eosinophils. (Pubmed Central) - Sep 4, 2024
Type 2 cytokines IL-4 and IL-13 induce basal cell hyperplasia, and basal cells exacerbate type 2 inflammation by producing TSLP in nasal polyp of eCRS. Omeprazole reduced the effects of IL-13 in both the epithelial air-liquid interface model and eosinophil-epithelial co-cultures, reducing barrier dysfunction, chemokine expression, and upregulation of eosinophil adhesion markers.
- | sirolimus / Generic mfg.
Preclinical, Journal: Mycobacterium vaccae attenuates airway inflammation by inhibiting autophagy and activating PI3K/Akt signaling pathway in OVA-induced allergic airway inflammation mouse model. (Pubmed Central) - Aug 22, 2024
In summary, the present study suggests that M. vaccae may contribute to alleviating airway inflammation and remodeling in allergic asthma by potentially modulating autophagy and the PI3K/Akt signaling pathway. These discoveries offer a promising avenue for the development of therapeutic interventions targeting allergic airway inflammation.
- cendakimab (CC-93538) / AbbVie, BMS
Cendakimab Exhibits Robust Anti-Fibrotic Effects by Inhibiting IL-13R?2 Signaling (Exhibit Hall E) - Aug 20, 2024 - Abstract #ACG2024ACG_4436;
When the parental gene IL13RA2 is knocked out, signaling does not occur. Cendakimab blocks IL-13 induced AP-1 production.
- | aspirin / Generic mfg.
Journal: IL-4R? signaling promotes barrier-altering oncostatin M and IL-6 production in aspirin-exacerbated respiratory disease. (Pubmed Central) - Aug 7, 2024
IL-4R? blockade, although seemingly directed at type 2 inflammation, also decreases mediators of innate inflammation and epithelial dysregulation, which may contribute to dupilumab's therapeutic efficacy in AERD.
- | Preclinical, Journal: NLRP3 Inflammasome Deficiency Alleviates Inflammation and Oxidative Stress by Promoting PINK1/Parkin-Mediated Mitophagy in Allergic Rhinitis Mice and Nasal Epithelial Cells. (Pubmed Central) - Aug 6, 2024
However, PINK1 knockdown abrogated mitophagy and also reversed the protective effects of MCC950 on inflammation, oxidative stress, and apoptosis in HNEpCs stimulated with IL-13. Inhibition of NLRP3 inflammasome exerts the protective effects on AR by facilitating mitophagy regulated by PINK1/Parkin signaling pathway.
- AUF-1 and skin inflammation: atopic dermatitis and psoriasis (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_2224;
This is the first investigation of AUF-1 in human chronic inflammatory skin diseases. Our results showed a different pattern of expression of AUF-1 in AD compared with psoriasis, suggesting a possible role of AUF-1 in chronic, immune-driven skin inflammation.
- cendakimab (CC-93538) / AbbVie, BMS
CENDAKIMAB EXHIBITS ROBUST ANTI-FIBROTIC EFFECTS BY INHIBITING IL-13R?2 SIGNALING (Poster Stage 6) - Jul 18, 2024 - Abstract #UEGW2024UEGW_3143;
These experiments confirm that IL-13R?2 is a signaling cytokine receptor whose engagement leads to the pro-fibrotic activation of primary human fibroblasts. Cendakimab
- | Journal: Peroxidase-mediated mucin cross-linking drives pathologic mucus gel formation in IL-13-stimulated airway epithelial cells. (Pubmed Central) - Jun 18, 2024
Finally, gene expression for TPO in airway epithelial brushings is increased in asthma patients with high airway mucus plug scores. Together, our results show that IL-13 activated HAECs autonomously generate pathologic mucus via peroxidase-mediated cross-linking of mucin polymers.
- | nintedanib / Generic mfg., pirfenidone / Generic mfg.
Biomarker, Preclinical, Journal: Osteoprotegerin is an Early Marker of the Fibrotic Process and of Antifibrotic Treatment Responses in Ex Vivo Lung Fibrosis. (Pubmed Central) - Jun 1, 2024
OPG can already be detected during the early stages of fibrosis development and responds, both in early- and late-stage fibrosis, to treatment with antifibrotic drugs currently on the market for lung fibrosis. Therefore, OPG should be further investigated as a potential biomarker for lung fibrosis and a potential surrogate marker for treatment effect.
- lunsekimig (SAR443765) / Sanofi
TSLP AND IL-13 Dual Blockade By Lunsekimig Provides Broader Benefits On Type-2 Inflammation (PS-14; Poster board no. 20) - May 31, 2024 - Abstract #ERS2024ERS_4807;
Indeed, lunsekimig was more potent in inhibiting TARC and eotaxin-3 production than targeting TSLP (tezepelumab) or IL-13 (lebrikizumab) alone in an allergen-stimulated triculture assay. Lunsekimig had significantly lowered plasma human IL
- Modeling mucus plugging during type 2-high severe asthma using human induced pluripotent stem cells (hiPSC). (PS-7; Poster board no. 17) - May 31, 2024 - Abstract #ERS2024ERS_2105;
P=N/A
To our knowledge, it is the first in vitro severe asthma human model of mucus plugging endotype. Further work is needed to unravel the molecular mechanisms between galectin- 10 crystals and mucus plugging.
- Inhibition of IL-4R? in bronchial epithelial cells reduces CCL26 and TSLP without affecting antiviral immune responses (PS-9; Poster board no. 10) - May 31, 2024 - Abstract #ERS2024ERS_441;
mAb treatment did not have any effect on epithelial anti-viral interferon response. However, blocking the T2- pathway resulted in down-modulation of CCL26 and TSLP indicating a possible positive treatment effect on preventing exacerbations by reduction of eosinophil chemotaxis and immune tolerance.
- Dupixent (dupilumab) / Sanofi, Regeneron
Dupilumab antagonizes the stimulatory effects of IL-13 on mucin production by human bronchial epithelium cells. (PS-9; Poster board no. 2) - May 31, 2024 - Abstract #ERS2024ERS_433;
Moreover, the potent antagonist action of Dupilumab against IL-13 showed the involvement of the IL-4 receptor alpha subunit in the mucin stimulatory effect of the cytokine. IL-13 / IL-4 R?/IL-13R?1 signalling pathway may be view as target for the development of innovative treatments for conditions link to mucin overproduction
- | Journal, IO biomarker: H3K27 acetylation promotes lncRNA OIP5-AS1 transcription and induces apoptosis of nasal epithelial cells in allergic rhinitis through up-regulation of TLR4 (Pubmed Central) - May 25, 2024
In addition, H3K27 acetylation was markedly enriched in the promoter region of OIP5-AS1, and H3K27 acetylation promoted the expression of OIP5-AS1 in IL-13-treated NECs. Conclusion H3K27 acetylation promotes OIP5-AS1 transcription and induces NEC apoptosis in AR via upregulation of TLR4.
- Decipher the effects of type 2-cytokines- and IL-22-induced epithelial barrier dysfunction and skin Inflammation in ex-vivo human skin (Poster Zone) - May 25, 2024 - Abstract #EAACI2024EAACI_2794;
Conclusion We demonstrated diverse effects of essential cytokines on epithelial barriers and AD-like inflammation using ex-vivo human skin, aiming to dissect their distinct function within the skin. Our findings might fill the gap between the pure in vitro data and the current multi-omics data on atopic dermatitis skin.
- | Journal: Lysyl oxidase regulates epithelial differentiation and barrier integrity in eosinophilic esophagitis. (Pubmed Central) - May 19, 2024
Our data support a model whereby LOX exhibits noncanonical roles as a signaling molecule important for epithelial homeostasis in the setting of inflammation via activation of the BMP pathway in the esophagus. The LOX/BMP axis may be integral in esophageal epithelial differentiation and a promising target for future therapies.
- | Journal: MEF2D facilitates liver metastasis of gastric cancer cells through directly inducing H1X under IL-13 stimulation. (Pubmed Central) - May 15, 2024
Targeting MEF2D could therefore be a promising therapeutic strategy for the clinical management of gastric cancer. STATEMENT OF SIGNIFICANCE: MEF2D promotes its transcriptional activation in gastric cancer cells by binding to the H1X promoter and is upregulated by IL-13-IL13RA1, thereby promoting distant metastasis of gastric cancer.
- | Preclinical, Journal: Suppressive Activity of Boiogito, a Japanese Traditional Kampo Medicine, on Periostin Secretion in Human Fibroblast-Like Synoviocytes In Vitro. (Pubmed Central) - May 7, 2024
By inhibiting periostin production and downstream signaling pathways, BOT may offer a promising conservative treatment option for KOA, addressing the inflammatory cascade implicated in disease progression. Further research is warranted to elucidate the specific herbal components responsible for the therapeutic effects of BOT and to validate its efficacy in clinical settings.
- | Journal: Multiwalled Carbon Nanotubes-Reprogrammed Macrophages Facilitate Breast Cancer Metastasis via NBR2/TBX1 Axis. (Pubmed Central) - Apr 16, 2024
Moreover, NBR2 overexpression mitigated the enhancing effects of MWCNT-exposed macrophages on breast cancer metastasis. This study uncovered the molecular mechanisms underlying breast cancer metastasis induced by MWCNT exposure.
- Decipher the effects of type 2-cytokines- and IL-22-induced epithelial barrier dysfunction and skin Inflammation in ex-vivo human skin (Bilbao) - Apr 5, 2024 - Abstract #EAACI2024EAACI_803;
Conclusion We demonstrated diverse effects of essential cytokines on epithelial barriers and AD-like inflammation using ex-vivo human skin, aiming to dissect their distinct function within the skin. Our findings might fill the gap between the pure in vitro data and the current multi-omics data on atopic dermatitis skin.
- Proton pump inhibitors decrease the expression of IL-13-stimulated CCL26/eotaxin-3 in airway epithelial cells through the modulation of IL-13Ra2 and extracellular signal-regulated kinase (ERK) activity (E-TPS Display Only Digital section) - Apr 5, 2024 - Abstract #EAACI2024EAACI_472;
Furthermore, IL-13 treatment induces an increase in the gene expression of IL-13R?2, not IL-13R?1, and this effect is attenuated by both PPIs and PD98059. Conclusion Our findings indicate that PPIs significantly inhibit IL-13-induced eotaxin-3, and this suppression is partly mediated through the IL-13R?2 and ERK signaling pathways.
- Delivery of antimiR-155 using lipid nanoparticles ameliorate liver fibrosis by alleviating macrophage-driven liver inflammation (Poster Area) - Apr 2, 2024 - Abstract #EASLILC2024EASL_ILC_935;
Conclusion Our findings indicate that PPIs significantly inhibit IL-13-induced eotaxin-3, and this suppression is partly mediated through the IL-13R?2 and ERK signaling pathways. We have developed a LNP platform to deliver antimiR-155 to ameliorate macrophage- driven liver inflammation and liver fibrosis.
- Modulation of IL-13 signal in allergic asthma. (Exhibit Hall F1; Poster Board Number: B917) - Mar 29, 2024 - Abstract #IMMUNOLOGY2024IMMUNOLOGY_2238;
Functionally, SRC antagonists reduced expression of multiple IL-13-induced gene in IL-13-treated A549 cells. Collectively, these data suggest that SRC may represent a novel signaling intermediate activated in response to IL-13, and that SRC antagonism may have therapeutic benefit in the treatment of asthma.
- Modulation of IL-13 signal in allergic asthma. (Room W181) - Mar 22, 2024 - Abstract #IMMUNOLOGY2024IMMUNOLOGY_467;
Functionally, SRC antagonists reduced expression of multiple IL-13-induced gene in IL-13-treated A549 cells. Collectively, these data suggest that SRC may represent a novel signaling intermediate activated in response to IL-13, and that SRC antagonism may have therapeutic benefit in the treatment of asthma.
- | Journal: Methyltransferase-like 3 (METTL3) Epigenetically Modulates Glutathione Peroxidase 4 (GPX4) Expression to Affect Asthma. (Pubmed Central) - Mar 17, 2024
Interestingly, METTL3 overexpression not only inhibited cell ferroptosis but also alleviated asthma symptoms. Our findings shed light on the epigenetic regulation of asthma through METTL3-mediated m6A modification, offering potential therapeutic avenues for this prevalent inflammatory disease.
- Synagis (palivizumab) / AbbVie, AstraZeneca, SOBI
RSV infection alters mice lung periostin, IL-4 and IL-13 expression levels (Convention Center Exhibit Hall) - Mar 16, 2024 - Abstract #PAS2024PAS_3951;
Penh in RSV infected mice mice compared with control and UV irradiated RSV infected mice was significantly increased (Figure 2) at dpi 1,2,5,7,9. Lung periostin, IL-4 and IL-13 expression levels at dpi 4 were significantly increased in RSV infected mice.
- | Journal: German cockroach extract prevents IL-13-induced CCL26 expression in airway epithelial cells through IL-13 degradation. (Pubmed Central) - Mar 15, 2024
We conclude that CE serine proteases antagonize IL-13-induced effects in AECs, and this CE effect is mediated primarily through proteolytic cleavage of IL-13. IL-13 cleavage by cockroach serine proteases may modulate CCL26-mediated effects in allergic airway inflammation by interfering directly with the pro-inflammatory effects of IL-13 in
- THE CD73-ADENOSINE AXIS PROMOTES DIFFERENTIATION OF ESOPHAGEAL EPITHELIUM IN EOSINOPHILIC ESOPHAGITIS (103AB - Walter E. Washington Convention Center) - Mar 14, 2024 - Abstract #DDW2024DDW_6038;
Currently, nothing is known about the role of purinergic signaling in the esophageal epithelium . These results demonstrate that restoration of adenosine signaling through the CD73-A2B axis may present a promising avenue for EoE therapy by restoring epithelial homeostasis.
- NOTCH SIGNALING MAY PROTECT AGAINST BASAL CELL HYPERPLASIA UNDER EOSINOPHILIC ESOPHAGITIS (Hall A) - Mar 14, 2024 - Abstract #DDW2024DDW_3023;
Amongst Sox + basaloid cells proliferative but not post-mitotic undifferentiated cells are likely to contribute to epithelial renewal in EoE-related BCH. Inhibition of Notch signaling augmented BCH suggesting a potential protective role of Notch signaling against EoE-related BCH.
- IL-13 Alters the Inflammatory and Metabolic Responses to Rhinovirus Infection Independent of Viral Load in Bronchial Epithelium From Children With Asthma (San Diego Convention Center, Room 33A-C (Upper Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_8024;
IL-13 stimulation of BEC cultures from children with asthma did not impact HRV replication, nor epithelial interferon response patterns. However, IL-13 significantly altered multiple inflammatory and metabolic pathways resultant from HRV infection that may drive airway inflammation and pathophysiologic changes associated with asthma exacerbation.
- Modeling Asthma Risk Alleles at the 17q12-21 Locus With an Induced Pluripotent Stem Cell Derived Airway Platform (San Diego Convention Center, Room 33A-C (Upper Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_8023;
High risk allele derived iPSC-airway demonstrates increased MUC5AC+ goblet cells in response to IL-13 and increased GSDMB and type I/III interferon response to the dsRNA mimetic Poly(I:C). These results are consistent with those of artificial GSDMB over expression in non-asthmatic iPSC-airways, which also results in increased type I/III interferon response to the dsRNA mimetic Poly(I:C).
- Peroxidase-mediated Mucin Cross-linking Explains Pathologic Mucus Gel Formation in IL-13-stimulated Airway Epithelial Cells (San Diego Convention Center, Area C (Hall A-B2, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_4227;
These results are consistent with those of artificial GSDMB over expression in non-asthmatic iPSC-airways, which also results in increased type I/III interferon response to the dsRNA mimetic Poly(I:C). IL-13 stimulation of epithelial cells causes mucus cross-linking and mucus gel stiffening via peroxidase-driven oxidant acid production.
- hydroxychloroquine / Generic mfg.
T2/IL-13-induced Autophagy Promotes RV-A16 Infection in Human Airway Epithelial Cells (San Diego Convention Center, Area C (Hall A-B2, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_4222;
IL-13/T2 conditions decrease ICAM-1 expression reducing initial RV-A16 attachment, while promoting replication post-attachment. Enhancement of autophagy/mitophagy under T2- conditions may contribute to this increase in replication, while only modestly increasing cell death.
- Differential Regulation of the Type 2 Cytokines, IL-4 and IL-13, and the Alarmins, IL-33 and TSLPA, in Airway Inflammation and Remodeling (San Diego Convention Center, Area C (Hall A-B2, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_3221;
Interestingly, IL-4 and IL-13 broadly impact immune and structural cells, IL-33 primarily acts on immune cells, and TSLP has no impact on primary or structural cells tested here. These findings correlate with effects in mouse models, with IL-4, IL-13 and IL-33 each inducing inflammation and remodeling in vivo.
- IL-13 Stimulation of Primary Bronchial Epithelial Cells Enhances Rhinovirus Replication (San Diego Convention Center, Area C (Hall A-B2, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_3216;
IL-13 pretreatment did not alter the initial cycle of RV-C15 replication but increased subsequent RV-C15replication cycles. These findings suggest that IL-13 enhances viral spread, possibly by disrupting cell-to-cell antiviral signaling.
- ONX 0914 / Protalex, Amgen
Immunoproteasome Inhibits Airway Type 2 Inflammation in Part Through the Degradation of IL4-Ralpha (Marriott Marquis San Diego Marina, Pacific Ballroom 24-26 (Ground Floor, North Tower)) - Feb 20, 2024 - Abstract #ATS2024ATS_2947;
Enhancing immunoproteasome expression or function may serve as a new therapeutic approach in attenuating allergic inflammation in asthma. Research Funding Source: R01AI150082
- | Journal, IO biomarker: Cirrhosis-downregulated LSECtin can be retrieved by cytokines, shifts the TLR-induced LSECs secretome and correlates with the hepatic Th response. (Pubmed Central) - Jan 31, 2024
LSECtin restrains TLR proinflammatory secretome induced on LSECs by interfering immune response control, survival and MAPKs signalling pathways. The cytokine-dependent induction of LSECtin and the association between LSECtin loss and Th17 cell subset expansion in the liver, provides a solid background for exploring LSECtin retrieval as a mechanism to reprogram LSEC homeostatic function hampered during cirrhosis.
- | Preclinical, Journal: Anti-Inflammatory Effects of the LK5 Herbal Complex on LPS- and IL-4/IL-13-Stimulated HaCaT Cells and a DNCB-Induced Animal Model of Atopic Dermatitis in BALB/c Mice. (Pubmed Central) - Jan 23, 2024
Furthermore, the LK5 herbal complex treatment significantly decreased the levels of inflammatory cytokines such as TSLP, IL-6, and IgE in plasma and ear tissue of AD-induced mice. These findings suggest that the LK5 herbal complex may modulate the immune response and alleviate AD symptoms by inhibiting STAT pathways.
- | Journal: TRPM2 exacerbates airway inflammation by regulating oxidized-CaMK? in allergic asthma. (Pubmed Central) - Jan 8, 2024
TRPM2 plays a vital role in regulating ox-CaMK? in airway epithelial cells during allergic asthma.
- | Jakafi (ruxolitinib) / Novartis, Incyte, Dupixent (dupilumab) / Sanofi, Regeneron
Journal: Th2 Cytokine Signaling through IL-4R? Increases Eotaxin-3 Secretion and Tension in Human Esophageal Smooth Muscle. (Pubmed Central) - Dec 21, 2023
This suggests that ESM eosinophilia and impaired esophageal distensibility might persist despite elimination of mucosal eosinophils by PPIs, and IL-4R? blocking agents might be especially useful in this circumstance.
- | Journal: Hyperforin modulates MAPK/CCL11 signaling to reduce the inflammatory response of nasal mucosal epithelial cells caused by allergic rhinitis by targeting BCL6. (Pubmed Central) - Nov 30, 2023
Silencing of BCL6 reversed the effects of hyperforin on IL-13-induced inflammation and barrier damage. In summary, the present results revealed that hyperforin suppressed IL-13-induced nasal epithelial cell inflammation and barrier damage by targeting BCL6/p38 MAPK/CCL11, which may provide promising therapeutic targets for AR.
- | Journal: Macrocystis pyrifera Lipids Reduce Cytokine-Induced Pro-Inflammatory Signalling and Barrier Dysfunction in Human Keratinocyte Models. (Pubmed Central) - Nov 29, 2023
Three-dimensional cultures of HaCaT cells differentiated at the air-liquid interface showed increased MCP-1 production, loss of claudin-1 tight junctions, and trans-epidermal leakage with TNF-?, IL-4, and IL-13 stimulation, with all parameters reduced by lipid pre-treatment. These findings suggest that M. pyrifera lipids have anti-inflammatory and barrier-protective effects on keratinocytes, which may be beneficial for the treatment of atopic dermatitis or other skin conditions.
- | Journal: Effects of Blocking NLRP3 Inflammasome on Type II Innate Lymphoid Cell Response in Allergic Rhinitis. (Pubmed Central) - Aug 16, 2023
MCC950 inhibited NLRP3 inflammasome in the in vitro models of AR. MCC950 inhibited ILC2 responses in AR and mice models, suggesting that blocking NLRP3 inflammasome may be a promising target for AR clinical treatment.
- | 101BHG-D01 / Beijing Shuobai Pharma
Preclinical, Journal: Effects of 101BHG-D01, a novel M receptor antagonism, on allergic rhinitis in animal models and its mechanism. (Pubmed Central) - Aug 14, 2023
Furthermore, IL-13 stimulation significantly increased JAK1 and STAT6 phosphorylation, which was suppressed by 101BHG-D01. We demonstrated that 101BHG-D01 reduced mucus secretion and inflammatory cell infiltration in the nasal mucosa, which may occur through a reduction in activation of the JAK1-STAT6 signaling pathway, indicating that 101BHG-D01 is a potent and safe anticholinergic therapy for AR.