University of Alabama Birmingham
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 124 Trials 
230 Trials

   

 
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Robert, Francisco
NCT04137900: Safety, Tolerability and Pharmacokinetics of a Monoclonal Antibody Specific to B-and T-Lymphocyte Attenuator (BTLA) as Monotherapy and in Combination With an Anti-PD1 Monoclonal Antibody for Injection in Subjects With Advanced Malignancies

Recruiting
1
499
US
TAB004, JS004, Toripalimab, TAB001, JS001
TopAlliance Biosciences, Shanghai Junshi Bioscience Co., Ltd., CTI Clinical Trial and Consulting Services
Advanced Unresectable Solid Tumor, Metastatic Solid Tumor
03/26
03/26
Lewis, Cora
NCT00005130: Coronary Artery Risk Development in Young Adults

Active, not recruiting
N/A
5115
NA
National Heart, Lung, and Blood Institute (NHLBI)
Cardiovascular Diseases, Coronary Disease, Hypertension, Heart Diseases, Obesity, Diabetes Mellitus
06/33
06/33
NCT04258332: CARDIA-Salt Sensitivity of Blood Pressure (SSBP)

Active, not recruiting
N/A
500
US
High Salt Diet, Low Salt Diet
Vanderbilt University Medical Center, Northwestern University, University of Alabama at Birmingham
Salt Sensitivity of Blood Pressure, Hypertension
05/25
05/25
Jansen, Jan
TROOP, NCT05638581: Trauma Resuscitation With Low-Titer Group O Whole Blood or Products

Recruiting
3
1100
US
LTOWB, Components
University of Alabama at Birmingham, National Heart, Lung, and Blood Institute (NHLBI), The University of Texas Health Science Center, Houston
Wounds and Injuries, Shock, Hemorrhagic
12/26
06/27
UP-FRONT, NCT05236920: Utility and Procedural Feasibility of REBOA Operationalized for Non-Trauma Application

Withdrawn
N/A
40
NA
Resuscitative Endovascular balloon occlusion of the aorta using a REBOA catheter device, REBOA procedure
University of Alabama at Birmingham
Cardiac Arrest, Out-Of-Hospital, Ventricular Fibrillation, Ventricular Tachycardia
10/22
10/22
CAPP, NCT04755179: Identification of the Optimal Treatment Strategy for Complex Appendicitis in the Pediatric Population

Completed
N/A
1308
Europe
Laparoscopic appendectomy, Open appendectomy, Non-operative treatment, Direct appendectomy
Ramon Gorter, ZonMw: The Netherlands Organisation for Health Research and Development, Amsterdam UMC, location VUmc
Appendicitis, Appendix Mass, Appendicitis Perforated
07/24
07/24
PhoXSTAT, NCT04663087: Feasibility of Evaluating XSTAT Use in the Prehospital Setting

Terminated
N/A
1
US
XSTAT, XSTAT 12, Standard of Care
University of Alabama at Birmingham
Shock, Hemorrhagic, Injury Penetrating, Hemorrhage
06/23
08/23
MOBI-1, NCT04893837: Non-Invasive Monitoring of Traumatic Brain Injury Progression Using the Infrascanner

Recruiting
N/A
440
US
Standard care plus infrascans
University of Alabama at Birmingham, United States Department of Defense, InfraScan, Inc.
Brain Injuries, Traumatic
06/25
06/25
III, Charles F Reynolds
CREST-H, NCT03121209: Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial - Hemodynamics

Active, not recruiting
3
385
Canada, US
Revascularization, Intensive Medical Management (IMM) alone
Columbia University, National Institute of Neurological Disorders and Stroke (NINDS), Mayo Clinic, University of Alabama at Birmingham, University of Maryland, University of California, Los Angeles
Internal Carotid Artery Stenosis, Cognitive Impairment
01/27
07/27
OVATION 2, NCT03393884: Study of IMNN-001 (Also Known as GEN-1) With NACT for Treatment of Ovarian Cancer

Checkmark Presentation of OVATION 2 data in advanced ovarian cancer
Mar 2021 - Mar 2021: Presentation of OVATION 2 data in advanced ovarian cancer
Active, not recruiting
1/2
130
Canada, US
IMNN-001, Carboplatin, Paclitaxel
Imunon
Epithelial Ovarian Cancer, Fallopian Tube Cancer, Primary Peritoneal Cancer
07/24
11/25
NCT03500757: Intra-procedural 360-degree Display for Performing Percutaneous Liver Tumor Ablation

Enrolling by invitation
N/A
15
US
HoloLens, headset
Case Comprehensive Cancer Center
Percutaneous Tumor Ablation
02/25
02/25
CREST-2, NCT02089217: Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial

Active, not recruiting
N/A
2486
Europe, Canada, US, RoW
Carotid endarterectomy (CEA), Carotid Stenting (CAS), Intensive Medical Management - no CEA, Intensive Medical Management - no CAS
Thomas G. Brott, M.D., National Institute of Neurological Disorders and Stroke (NINDS)
Carotid Stenosis
02/26
02/26
Shelton, Richard C
SMART-BD, NCT06433635: Sequential Multiple Assignment Randomized Trial for Bipolar Depression

Not yet recruiting
4
2726
Canada, US
Cariprazine, Vraylar, Aripiprazole/Escitalopram combination, Abilify/ Lexapro, Quetiapine, Seroquel, Lurasidone, Latuda
Massachusetts General Hospital, Patient-Centered Outcomes Research Institute
Bipolar I Disorder, Depression
02/30
02/30
NCT05169710 / 2021-002126-24: A Clinical Study of an Investigational Drug for the Treatment of Major Depressive Episode Associated With Bipolar I Disorder.

Terminated
3
83
Europe, Canada, Japan, US
SEP-4199 CR 200 mg, SEP-4199 CR 400 mg, Placebo
Sumitomo Pharma America, Inc., Sunovion Pharmaceuticals Inc.
Depressive Episodes, Bipolar I Depression
10/23
10/23
NCT05729373: A Clinical Study That Will Measure How Well SEP-363856 Works and How Safe it is in Adults With Generalized Anxiety Disorder

Recruiting
2/3
434
Europe, Japan, US
SEP-363856, Placebo
Otsuka Pharmaceutical Development & Commercialization, Inc.
Generalized Anxiety Disorder
02/26
02/26
ENLIGHTEN, NCT05113771: A Biomarker-Guided, Randomized, Double-Blind, Placebo-Controlled Efficacy and Safety Study of Liafensine in Patients With Treatment-Resistant Depression

Completed
2
197
Canada, US
Liafensine, Placebo
Denovo Biopharma LLC
Treatment Resistant Depression
02/24
03/24
NCT04923685: MicroRNA Correlates of Childhood Maltreatment and Suicidality

Recruiting
N/A
450
US
Trier Social Stress Test, TSST
University of Alabama at Birmingham, National Institute of Mental Health (NIMH)
Major Depressive Disorder, Suicidal Ideation
09/25
09/25
NCT05437588: Neural-Derived Plasma Exosomal MicroRNAs As Promising Novel Biomarkers for Suicidality and Treatment Outcome in Adolescents

Recruiting
N/A
240
US
Genetic testing
University of Alabama at Birmingham, National Institute of Mental Health (NIMH)
Major Depressive Disorder, Suicidal Ideas, Suicide, Attempted, MDD, Depression, Depression, Teen, Depression and Suicide, Depression in Adolescence, Suicide
06/27
06/27
RECOVER, NCT03887715: A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression

Recruiting
N/A
6800
US
Vagus Nerve Stimulation (VNS), VNS
LivaNova
Treatment Resistant Depression
02/28
12/30
Locke, Jayme
NCT05340426: Porcine Kidney Xenotransplantation in Patients With End-Stage Kidney Disease

Withdrawn
1
20
US
UKidney, Porcine Kidney, Xenotransplant
University of Alabama at Birmingham, United Therapeutics, Lung Biotechnology PBC
Kidney Failure, Chronic
06/28
06/29
NCT04341896: Healthcare Utilization in Obese Caregiver Living Donors

Completed
N/A
784
US
Caregivers, Non-caregivers
University of Alabama at Birmingham
Utilization, Health Care, Obesity
03/24
12/24
PILOT, NCT05468463: Promoting Increases in Living Donation Via Tele-navigation

Enrolling by invitation
N/A
440
US
Living Donor Navigator Program
University of Alabama at Birmingham, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Kidney Diseases
11/25
02/26
Gilbert, Gregg H
PAAS, NCT06131021: Shaping the Indications for Periodontal Adjunctive Antibiotics in Dental Practice

Recruiting
3
544
US
Amoxicillin, Metronidazole, Placebo
Rutgers, The State University of New Jersey, National Institute of Dental and Craniofacial Research (NIDCR), National Dental PBRN
Periodontitis, Periodontal Diseases, Periodontal Pocket
01/26
05/26
NCT04509115: Variation in Opioid Prescribing and Use for Acute Pain in Diverse Populations

Completed
N/A
1709
US
Short-acting opioid prescription for acute pain
Yale University, Food and Drug Administration (FDA)
Opioid Use, Opioid Prescribing
11/23
11/23
Wilcox, Charles M
EPOCH, NCT06178315: EUS-guided Celiac Plexus Block vs. Sham in Chronic Pancreatitis

Recruiting
N/A
94
US
EUS-guided celiac plexus block, Sham procedure
Orlando Health, Inc.
Chronic Pancreatitis
12/25
12/26
Wells, Gretchen
WARRIOR, NCT03417388: Women's IschemiA TRial to Reduce Events In Non-ObstRuctive CAD

Active, not recruiting
4
2476
US
High dose potent statin, atorvastatin or rosuvastatin, ACE-I (lisinopril) or ARB (losartan), ACE-I or ARB, Aspirin, Lifestyle Counseling, PACE Lifestyle Intervention, Quality of Life Questionnaires, QOL
University of Florida, United States Department of Defense
Coronary Artery Disease
02/25
09/25
REBIRTH, NCT05180773: Impact of Bromocriptine on Clinical Outcomes for Peripartum Cardiomyopathy

Recruiting
4
250
US
Bromocriptine, Parlodel, Cycloset, Placebo, Guideline Directed Medical Therapy for Heart Failure (GDMT), Rivaroxaban, Xarelto, Second Placebo
Dennis M. McNamara, MD, MS, National Heart, Lung, and Blood Institute (NHLBI)
Peripartum Cardiomyopathy, Postpartum
06/26
12/28
Saag, Kenneth G
NCT04177940 / 2020-004903-15: Denosumab (DMAB) Discontinuation and Switching in Glucocorticoid-Induced Osteoporosis (GIOP): a Pilot Study

Active, not recruiting
4
45
US
DMAB Discontinuation and Switching
University of Alabama at Birmingham, Maastricht University, Vrije Universiteit Brussel, Amgen
Osteoporosis
08/25
08/25
NCT04511702: Infusion Duration Study To Assess Tolerability of Pegloticase Administered With a Shorter Infusion Duration in Subjects With Uncontrolled Gout Receiving Methotrexate

Completed
4
191
US
Pegloticase with MTX, Methotrexate
Amgen
Chronic Uncontrolled Gout, Gout, Uncontrolled Gout
01/24
03/24
TRUST, NCT04875702: Treat-to-Target Serum Urate Versus Treat-to-Avoid Symptoms in Gout

Recruiting
4
650
US
Allopurinol, Aloprim, Zyloprim, Naproxen 250 MG, Prophylaxis, Colchicine 0.6 mg, Colchicine 1.2 mg, Flare, Naproxen 500 Mg, Prednisone 40 mg
Massachusetts General Hospital, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Gout
09/28
10/28
NCT05658575 / 2019-002717-19: Study of Dapansutrile Tablets in Subjects With an Acute Gout Flare

Recruiting
2/3
300
Europe, US, RoW
Dapansutrile, OLT1177, Placebo Tablet
Olatec Therapeutics LLC, Olatec Therapeutics LLC
Acute Gout Flare, Gout Attack, Gout Flare, Gouty Arthritis, Gout, Arthritis, Joint Pain
09/25
10/25
NCT04075903: Gout in the ED and Improving Research Participation

Active, not recruiting
N/A
280
US
Storytelling
University of Alabama at Birmingham, Massachusetts General Hospital, MetroHealth Medical Center, University of Iowa, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Gout
09/24
12/24
CARE-Gout, NCT06534554: Improving Gout Care After an ED Visit

Recruiting
N/A
200
US
Patient Navigation
University of Alabama at Birmingham
Gout
01/26
06/26
RESTORE, NCT06455085: REducing Future FractureS and Improving OuTcOmes of FRagility FracturE

Recruiting
N/A
2634
US
Augmented-Fracture Liaison Service Arm, Enhanced Usual Care Arm
University of Alabama at Birmingham, Patient-Centered Outcomes Research Institute
Osteoporosis, Osteoporotic Fractures
06/29
06/29
Harper, Lorie M
MD30 RCT, NCT05262738: Misoprostol Dosing in BMI Greater Than 30

Completed
4
180
US
50 Micrograms Vaginal Misoprostol (Intervention), Cytotec, 25 Micrograms Vaginal Misoprostol (Control)
University of Texas at Austin
Pregnancy Related, Obesity, Labor Onset and Length Abnormalities
07/23
07/23
DECIDE, NCT06445946: A Comparative Effectiveness Trial of Metformin Versus Insulin for the Treatment of Gestational Diabetes

Recruiting
4
1572
US
Metformin, Insulin
Ohio State University, Patient-Centered Outcomes Research Institute, The George Washington University Biostatistics Center
Gestational Diabetes Mellitus, Pregnancy, High Risk
12/29
12/30
NCT05264779: The Periviable GOALS Decision Support Tool

Recruiting
N/A
216
US
Periviable GOALS DST
Indiana University, Agency for Healthcare Research and Quality (AHRQ)
Pregnancy Preterm, Premature Birth, Pregnancy Complications, Obstetric Labor, Premature, Obstetric Labor Complications
08/25
02/26
Wang, Henry
ELSA-2, NCT05128955: Embolization of the Splenic Artery After Trauma

Recruiting
N/A
250
US
Splenic artery embolization with vascular embolic coils or plugs
Andrew J. Gunn, Penumbra Inc.
High-grade Splenic Injuries
04/25
04/25
Pedi-PART, NCT06364280: Pediatric Prehospital Airway Resuscitation Trial

Recruiting
N/A
3000
US
BVM, SGA, ETI
Ohio State University, National Heart, Lung, and Blood Institute (NHLBI), University of Utah
Heart Arrest, Out-Of-Hospital, Wounds and Injuries, Respiratory Insufficiency in Children, Child, Only, Critical Illness
08/29
09/29
ICECAP, NCT04217551: Influence of Cooling Duration on Efficacy in Cardiac Arrest Patients

Recruiting
N/A
1800
US
Therapeutic Hypothermia
University of Michigan, Johns Hopkins University, Medical University of South Carolina, National Institutes of Health (NIH), National Institute of Neurological Disorders and Stroke (NINDS)
Cardiac Arrest, Out-Of-Hospital, Hypothermia, Induced, Hypoxia-Ischemia, Brain
07/28
08/28
Amara, Amy
NCT06219629: Parkinson's Disease Progression Study

Recruiting
N/A
70
US
Koneksa Health, Merck Sharp & Dohme LLC, Regeneron Pharmaceuticals
Parkinson Disease
08/25
09/25
NCT05437640: Optimizing Protein Patterns for Skeletal Muscle Preservation and Sleep in the Medical Management of Parkinson Disease

Completed
N/A
12
US
Protein Redistribution Diet, PRD, Protein Consistent Diet, PCD
University of Alabama at Birmingham
Parkinson Disease
11/24
11/24
NCT04796506: Slow Wave Sleep As a Biomarker of Rehabilitation-induced Cognitive Improvement in PD

Recruiting
N/A
120
US
Progressive Resistance Training (PRT), PRT, Delayed Exercise Training (DE), Endurance Training (ET), ET
University of Colorado, Denver, National Institutes of Health (NIH), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Parkinson Disease
03/26
03/26
Roberson, Erik
DIAN-TU, NCT06384573: Amyloid Removal Trial (ART) in Dominantly Inherited Alzheimer's Disease

Recruiting
3
65
Europe, US, RoW
lecanemab, BAN2401
Washington University School of Medicine, Alzheimer's Association, Eisai Inc.
Alzheimer's Disease, Dementia, Alzheimer's Disease, Familial
11/29
11/29
DIAN-TU-002, NCT06647498: A Study of a Potential Disease Modifying Treatment in Individuals at Risk for or With a Type of Early Onset AD Caused by a Genetic Mutation

Recruiting
2/3
280
Europe, Canada, US, RoW
Remternetug, LY3372993, Matching Placebo (Remternetug)
Washington University School of Medicine, Alzheimer's Association, Eli Lilly and Company, National Institute on Aging (NIA), GHR Foundation, Private Donors
Alzheimers Disease, Dementia, Alzheimers Disease, Familial
03/34
08/34
DIAN-TU, NCT05269394: Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation

Active, not recruiting
2/3
197
Europe, Canada, Japan, US, RoW
E2814, Lecanemab, BAN2401, Matching Placebo (E2814)
Washington University School of Medicine, Alzheimer's Association, National Institute on Aging (NIA), Accelerating Medicines Partnership (AMP), Eisai Inc.
Alzheimers Disease, Dementia, Alzheimers Disease, Familial
04/28
07/28
DIAN-TU, NCT01760005 / 2013-000307-17: Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation. Master Protocol -001

Checkmark From DIAN-TU trial
Feb 2020 - Feb 2020: From DIAN-TU trial
Checkmark Top-line data from DIAN-TU trial in rare inherited form of Alzheimer's disease
Feb 2020 - Feb 2020: Top-line data from DIAN-TU trial in rare inherited form of Alzheimer's disease
Checkmark DIAN TU: N=210
More
Recruiting
2/3
490
Europe, Canada, Japan, US, RoW
Gantenerumab, RO4909832, Solanezumab, LY2062430, Matching Placebo (Gantenerumab), Matching Placebo (Solanezumab), E2814, Lecanemab, BAN2401, Matching Placebo (E2814)
Washington University School of Medicine, Eli Lilly and Company, Hoffmann-La Roche, Alzheimer's Association, National Institute on Aging (NIA), Avid Radiopharmaceuticals, Accelerating Medicines Partnership (AMP), Eisai Inc., Janssen, LP
Alzheimers Disease, Dementia, Alzheimers Disease, Familial
04/28
07/28
DIAN-TU, NCT05552157: A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset AD Caused by a Genetic Mutation

Recruiting
2/3
280
Europe, Canada, US, RoW
Remternetug (SC), Matching Placebo (Remternetug)
Washington University School of Medicine, Alzheimer's Association, Eli Lilly and Company, National Institute on Aging (NIA)
Alzheimers Disease, Dementia, Alzheimers Disease, Familial
03/34
08/34
NCT04363684: ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)

Recruiting
N/A
2100
Canada, US
Mayo Clinic, University of California, San Francisco, National Institute on Aging (NIA), National Institute of Neurological Disorders and Stroke (NINDS)
Frontotemporal Lobar Degeneration (FTLD), Progressive Supranuclear Palsy (PSP), Corticobasal Degeneration (CBD), Behavioral Variant Frontotemporal Dementia (bvFTD), Semantic Variant Primary Progressive Aphasia (svPPA), Nonfluent Variant Primary Progressive Aphasia (nfvPPA), FTD With Amyotrophic Lateral Sclerosis (FTD/ALS), Amyotrophic Lateral Sclerosis, Oligosymptomatic PSP (oPSP), C9orf72, GRN Related Frontotemporal Dementia, MAPT Gene Mutation, TBK1 Gene Mutation, Oligosymptomatic Progressive Supranuclear Palsy
06/25
06/25
Chewning, Joseph
NCT05457556: Mismatched Related Donor Versus Matched Unrelated Donor Stem Cell Transplantation for Children, Adolescents, and Young Adults With Acute Leukemia or Myelodysplastic Syndrome

Recruiting
3
435
Canada, US, RoW
Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Bone Marrow Aspiration, Busulfan, 1, 4-Bis[methanesulfonoxy]butane, BUS, Busilvex, Bussulfam, Busulfanum, Busulfex, Busulphan, CB 2041, CB-2041, Glyzophrol, GT 41, GT-41, Joacamine, Methanesulfonic Acid Tetramethylene Ester, Methanesulfonic acid, tetramethylene ester, Mielucin, Misulban, Misulfan, Mitosan, Myeleukon, Myeloleukon, Myelosan, Mylecytan, Myleran, Sulfabutin, Tetramethylene Bis(methanesulfonate), Tetramethylene bis[methanesulfonate], WR-19508, Cyclophosphamide, (-)-Cyclophosphamide, 2H-1,3,2-Oxazaphosphorine, 2-[bis(2-chloroethyl)amino]tetrahydro-, 2-oxide, monohydrate, Asta B 518, B 518, B-518, B518, Carloxan, Ciclofosfamida, Ciclofosfamide, Cicloxal, Clafen, Claphene, CP monohydrate, CTX, CYCLO-cell, Cycloblastin, Cycloblastine, Cyclophospham, Cyclophosphamid monohydrate, Cyclophosphamide Monohydrate, Cyclophosphamidum, Cyclophosphan, Cyclophosphane, Cyclophosphanum, Cyclostin, Cyclostine, Cytophosphan, Cytophosphane, Cytoxan, Fosfaseron, Genoxal, Genuxal, Ledoxina, Mitoxan, Neosar, Revimmune, Syklofosfamid, WR 138719, WR- 138719, WR-138719, WR138719, Echocardiography, EC, Fludarabine, Fluradosa, Haploidentical Hematopoietic Cell Transplantation, Haploidentical Stem Cell Transplantation, HLA-Haploidentical Hematopoietic Cell Transplantation, Stem Cell Transplantation, Haploidentical, Lapine T-Lymphocyte Immune Globulin, Anti-Thymocyte Globulin Rabbit, Antithymocyte Globulin Rabbit, Antithymocyte globulin rabbit ATG, Grafalon, Imtix, Rabbit Anti-Human Thymocyte Globulin (RATG), Rabbit Anti-Thymocyte Globulin, Rabbit Antithymocyte Globulin, Rabbit ATG, Thymoglobulin, Lumbar Puncture, LP, Spinal Tap, Matched Unrelated Donor Hematopoietic Cell Transplantation, MUD-HCT, Melphalan, Alanine Nitrogen Mustard, CB-3025, L-PAM, L-Phenylalanine Mustard, L-Sarcolysin, L-Sarcolysin Phenylalanine mustard, L-Sarcolysine, Melphalan for Injection-Hepatic Delivery System, Melphalanum, Phenylalanine Mustard, Phenylalanine Nitrogen Mustard, Sarcoclorin, Sarkolysin, WR-19813, Methotrexate, Abitrexate, Alpha-Methopterin, Amethopterin, Brimexate, CL 14377, CL-14377, Emtexate, Emthexat, Emthexate, Farmitrexat, Fauldexato, Folex, Folex PFS, Lantarel, Ledertrexate, Lumexon, Maxtrex, Medsatrexate, Metex, Methoblastin, Methotrexate LPF, Methotrexate Methylaminopterin, Methotrexatum, Metotrexato, Metrotex, Mexate, Mexate-AQ, MTX, Novatrex, Rheumatrex, Texate, Tremetex, Trexeron, Trixilem, WR-19039, Multigated Acquisition Scan, Blood Pool Scan, Equilibrium Radionuclide Angiography, Gated Blood Pool Imaging, Gated Heart Pool Scan, MUGA, MUGA Scan, Multi-Gated Acquisition Scan, Radionuclide Ventriculogram Scan, Radionuclide Ventriculography, RNVG, SYMA Scanning, Synchronized Multigated Acquisition Scanning, Mycophenolate Mofetil, CellCept, MMF, Myeloablative Conditioning, Myeloablation, Myeloablative, Myeloablative Cytoreduction, Quality-of-Life Assessment, Quality of Life Assessment, Questionnaire Administration, Rituximab, ABP 798, BI 695500, BI-695500, BI695500, Blitzima, C2B8 Monoclonal Antibody, Chimeric Anti-CD20 Antibody, CT-P10, IDEC 102, IDEC-102, IDEC-C2B8, IDEC-C2B8 Monoclonal Antibody, IDEC102, Ikgdar, Mabtas, MabThera, Monoclonal Antibody IDEC-C2B8, PF 05280586, PF-05280586, PF05280586, Riabni, Ritemvia, Rituxan, Rituximab ABBS, Rituximab ARRX, Rituximab Biosimilar ABP 798, Rituximab Biosimilar BI 695500, Rituximab Biosimilar CT-P10, Rituximab Biosimilar GB241, Rituximab Biosimilar IBI301, Rituximab Biosimilar JHL1101, Rituximab Biosimilar PF-05280586, Rituximab Biosimilar RTXM83, Rituximab Biosimilar SAIT101, Rituximab Biosimilar SIBP-02, rituximab biosimilar TQB2303, Rituximab PVVR, Rituximab-abbs, Rituximab-arrx, Rituximab-blit, Rituximab-pvvr, Rituximab-rite, Rituximab-rixa, Rituximab-rixi, Rixathon, Riximyo, RTXM 83, RTXM-83, RTXM83, Ruxience, Truxima, T-Cell Depletion Therapy, T-Cell Depletion, T-Lymphocyte Depletion Therapy, Tacrolimus, FK 506, FK-506, FK506, Fujimycin, Hecoria, Prograf, Protopic, Tacforius, Thiotepa, 1,1',1''-Phosphinothioylidynetrisaziridine, Girostan, N,N', N''-Triethylenethiophosphoramide, Oncotiotepa, SH 105, SH-105, SH105, STEPA, Tepadina, Tepylute, TESPA, Tespamin, Tespamine, Thio-Tepa, Thiofosfamide, Thiofozil, Thiophosphamide, Thiophosphoamide, Thiophosphoramide, Thiotef, Tifosyl, TIO TEF, Tio-tef, Triethylene Thiophosphoramide, Triethylenethiophosphoramide, Tris(1-aziridinyl)phosphine sulfide, TSPA, WR 45312, Total-Body Irradiation, SCT_TBI, TBI, Total Body Irradiation, Whole Body, Whole Body Irradiation, Whole-Body Irradiation
Children's Oncology Group
Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, Mixed Phenotype Acute Leukemia, Myelodysplastic Syndrome
12/27
12/27
NCT05711667: A Study of the Drug Letermovir as Prevention of Cytomegalovirus Infection After Stem Cell Transplant in Pediatric Patients

Active, not recruiting
3
143
US
Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Letermovir, 2-((4S)-8-Fluoro-2-(4-(3-methoxyphenyl)piperazin-1-yl)-3-(2-methoxy-5-(trifluoromethyl)phenyl)-4H-quinazolin-4-yl)acetic Acid, AIC246, MK-8228, Prevymis
Children's Oncology Group
Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
06/28
06/28
ONC1701, NCT03509961: The EndRAD Trial: Eliminating Total Body Irradiation (TBI) for NGS-MRD Negative Children, Adolescents, and Young Adults With B-ALL

Recruiting
2
95
US
NGS-MRD, Myeloablative allogeneic HCT with a non-TBI conditioning regimen
Children's Hospital Los Angeles
B-cell Acute Lymphoblastic Leukemia
07/25
07/26
NCT05569512: Uproleselan With Pre-Transplant Conditioning in Hematopoietic Stem Cell Transplantation for AML

Terminated
1
1
US
Uproleselan, Fludarabine, Fludara, Clofarabine, Clolar, Busulfan, Busulfex, Myleran
Malika Kapadia, GlycoMimetics Incorporated
Acute Myeloid Leukemia, Pediatric Cancer
10/23
12/23
NCT03718546: Identifying Predictors of Poor Health-Related Quality-of-Life Among Pediatric Hematopoietic Stem Cell Donors

Active, not recruiting
N/A
754
US
Center for International Blood and Marrow Transplant Research, University of Pittsburgh
Quality of Life
08/24
08/24
NCT01351545: A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs)

Recruiting
N/A
99999
US
A multicenter access and distribution protocol for unlicensed cryopreserved cord blood units (CBUs)
Center for International Blood and Marrow Transplant Research, National Marrow Donor Program
Hematologic Malignancies, Inherited Disorders of Metabolism, Inherited Abnormalities of Platelets, Histiocytic Disorders, Acute Myelogenous Leukemia (AML or ANLL), Acute Lymphoblastic Leukemia (ALL), Other Acute Leukemia, Chronic Myelogenous Leukemia (CML), Myelodysplastic (MDS) / Myeloproliferative (MPN) Diseases, Other Leukemia, Hodgkin Lymphoma, Non-hodgkin Lymphoma, Multiple Myeloma/ Plasma Cell Disorder (PCD), Inherited Abnormalities of Erythrocyte Differentiation or Function, Disorders of the Immune System, Autoimmune Diseases, Severe Aplastic Anemia
10/41
10/41
Jackson, Elizabeth A
RED-AF, NCT04357288: Randomized Evaluation of Decision Support Interventions for Atrial Fibrillation

Completed
N/A
1117
US
Patient Decision Aid, Encounter Decision Aid
University of Utah, American Heart Association, Patient-Centered Outcomes Research Institute, Mayo Clinic, Northwestern University, Vanderbilt University, University of Michigan, University of Alabama at Birmingham
Atrial Fibrillation
09/24
09/24
NCT05270694: Evaluating Public Health Interventions to Improve COVID-19 Testing Among Underserved Populations

Completed
N/A
102
US
Public Health Intervention Package
Kathleen Fairfield, MaineHealth
COVID-19
11/23
11/23
NCT03827187: Awareness Detection and Communication in Disorders of Consciousness

Recruiting
N/A
30
Europe
Motor imagery based EEG-BCI
University of Ulster, National Rehabilitation Hospital, Ireland, Belfast Health and Social Care Trust, Western Health and Social Care Trust, Southern Health and Social Care Trust, Northern Health and Social Care Trust, Barnsley Hospital NHS Foundation Trust, NHS Lothian, Walton Centre NHS Foundation Trust, Hull University Teaching Hospitals NHS Trust, Imperial College Healthcare NHS Trust, Royal Hospital for Neuro-disability, South Warwickshire NHS Foundation Trust, Sheffield Teaching Hospitals NHS Foundation Trust, Oxford University Hospitals NHS Trust, Castel Froma Neuro Care, Inspire Neurocare, The Huntercombe Group, Active Care Group
Disorder of Consciousness, Paralysis, Motor Neuron Disease, Stroke, Physical Disability
08/26
08/26
TREK-PAD, NCT06033924: Telehealth Delivered Home-based Walking for Vets With Peripheral Artery Disease

Recruiting
N/A
225
US
Walking Program: Internet-based, Walking Program: Telehealth-based
VA Office of Research and Development
Peripheral Artery Disease
10/27
10/27
Beck, Adam W
NCT05004051: ViTAA Registry Pre- and Post-Operative Monitoring for Endovascular Aortic Aneurysm Repair and Serial Monitoring for AAA

Recruiting
N/A
200
Canada, US
ViTAA Analysis
ViTAA Medical Solutions
Abdominal Aortic Aneurysms
12/26
12/26
TRIOMPHE, NCT04471909: NEXUS Aortic Arch Clinical Study to Evaluate Safety and Effectiveness

Recruiting
N/A
110
US, RoW
NEXUS Aortic Stent Graft System
Endospan Ltd.
Aortic Dissection, Aortic Aneurysm, Intramural Hematoma, Penetrating Aortic Ulcer
11/24
10/29
TAMBE, NCT05442489: Evaluation of the GORE® EXCLUDER® Thoracoabdominal Branch Endoprosthesis in the Treatment of the Thoracoabdominal and Pararenal Aortic Aneurysms

Approved for marketing
N/A
US
GORE Excluder Thoracoabdominal Branch Endoprosthesis, TAMBE
W.L.Gore & Associates
Thoracoabdominal Aneurysm
 
 
NCT04941157: Prophylactic vs Therapeutic Cerebrospinal Fluid Drain Placement During Endovascular Thoracoabdominal Aortic Aneurysm Repair

Completed
N/A
20
US
Cerebrospinal Fluid Drain Placement
University of Alabama at Birmingham, University of Massachusetts, Worcester, The University of Texas Health Science Center, Houston
Spinal Cord Ischemia
05/24
05/24
NCT04875429: Zenith® Fenestrated+ Clinical Study

Recruiting
N/A
102
US
Zenith Fenestrated+ Endovascular Graft in combination with the BeGraft Balloon-Expandable FEVAR Bridging Stent Graft System and Unibody2
Cook Research Incorporated
Aortic Aneurysm, Abdominal, Juxtarenal Aortic Aneurysm, Extent IV Thoracoabdominal, Pararenal Aneurysm
06/26
04/31
NCT02043691: Evaluation of the Cook Custom Aortic Endograft, the Zenith t-Branch Endovascular Graft, and Surgeon-Modified Endograft in Treating Aortic Pathologies

Recruiting
N/A
300
US
Cook Custom Aortic Endograft, Zenith t-Branch Endovascular Graft, Surgeon-Modified Endograft
University of Alabama at Birmingham, Cook Group Incorporated
Juxtarenal Aortic Aneurysm, Suprarenal Aortic Aneurysm, Thoracoabdominal Aortic Aneurysm, Penetrating Aortic Ulcer
10/27
10/27
TAMBE, NCT03728985: Evaluation of the GORE® EXCLUDER® Thoracoabdominal Branch Endoprosthesis in the Treatment of Thoracoabdominal and Pararenal Aortic Aneurysms

Active, not recruiting
N/A
102
Europe, US
GORE EXCLUDER Thoracoabdominal Branch Endoprosthesis, TAMBE
W.L.Gore & Associates
Thoracoabdominal Aortic Aneurysm
01/23
09/26
Kurz, Michael
UP-FRONT, NCT05236920: Utility and Procedural Feasibility of REBOA Operationalized for Non-Trauma Application

Withdrawn
N/A
40
NA
Resuscitative Endovascular balloon occlusion of the aorta using a REBOA catheter device, REBOA procedure
University of Alabama at Birmingham
Cardiac Arrest, Out-Of-Hospital, Ventricular Fibrillation, Ventricular Tachycardia
10/22
10/22
ICECAP, NCT04217551: Influence of Cooling Duration on Efficacy in Cardiac Arrest Patients

Recruiting
N/A
1800
US
Therapeutic Hypothermia
University of Michigan, Johns Hopkins University, Medical University of South Carolina, National Institutes of Health (NIH), National Institute of Neurological Disorders and Stroke (NINDS)
Cardiac Arrest, Out-Of-Hospital, Hypothermia, Induced, Hypoxia-Ischemia, Brain
07/28
08/28
Rizk, Dana
EAGLE, NCT03749447 / 2018-003253-24: An Extended Access Program for Bardoxolone Methyl in Patients With CKD

Terminated
3
270
Europe, Japan, US, RoW
Bardoxolone methyl, RTA 402
Reata, a wholly owned subsidiary of Biogen, Reata Pharmaceuticals, Inc.
Chronic Kidney Diseases, Alport Syndrome, Autosomal Dominant Polycystic Kidney
08/23
08/23
FALCON, NCT03918447 / 2018-004651-20: A Trial of Bardoxolone Methyl in Patients With ADPKD -

Terminated
3
667
Europe, Japan, US, RoW
Bardoxolone methyl oral capsule, RTA 402, Placebo oral capsule
Reata, a wholly owned subsidiary of Biogen, Reata Pharmaceuticals, Inc., REATA PHARMACEUTICALS, INC
Autosomal Dominant Polycystic Kidney, ADPKD
08/23
08/23
ALIGN, NCT04573478: Atrasentan in Patients With IgA Nephropathy

Active, not recruiting
3
404
Europe, Canada, Japan, US, RoW
Atrasentan, CHK-01, Atrasentan Hydrochloride, ABT-627, Placebo
Chinook Therapeutics, Inc.
IgA Nephropathy, Immunoglobulin A Nephropathy
12/26
12/26
REBOOT, NCT03949855: Belimumab With Rituximab for Primary Membranous Nephropathy

Recruiting
2
58
Canada, US
Belimumab, Benlysta®, Placebo for Belimumab, Belimumab placebo, Rituximab, Rituxan®
National Institute of Allergy and Infectious Diseases (NIAID), Immune Tolerance Network (ITN), GlaxoSmithKline, PPD DEVELOPMENT, LP, Rho Federal Systems Division, Inc.
Membranous Nephropathy, Nephrotic Syndrome
03/29
03/30
ASSIST, NCT05834738: Randomized, Double-blind, Placebo-controlled, Crossover Study of Atrasentan in Subjects With IgA Nephropathy

Recruiting
2
52
Europe, US, RoW
Atrasentan, CHK-01, Atrasentan Hydrochloride, ABT-627, Placebo
Chinook Therapeutics, Inc.
IgA Nephropathy, Immunoglobulin A Nephropathy
10/25
08/26
Motl, Robert W
FBI21, NCT05528549: Blood Flow and Blood Pressure Investigation in Down Syndrome

Completed
3
48
US
Exercise
University of Illinois at Chicago, American College of Sports Medicine
Down Syndrome
04/23
04/23
NCT04866732: Physical Activity Program for Cardiac Health Among Older African American Populations

Not yet recruiting
N/A
30
NA
Physical Activity Cardiac Health Program
University of Alabama, Tuscaloosa, University of Alabama at Birmingham
Cardiovascular, Disease
06/22
07/22
NCT04782466: ATOMIC (Active Teens Multiple Sclerosis) Physical Activity Research Program

Recruiting
N/A
56
Canada, US
Physical Activity (PA) Intervention, Waitlist attention-control
The Hospital for Sick Children, Children's Hospital of Philadelphia, University of Alabama at Birmingham, Queen's University, National Multiple Sclerosis Society
Pediatric Multiple Sclerosis
09/23
09/23
NCT06404047: RECOVER-ENERGIZE Platform Protocol

Recruiting
N/A
660
US
Personalized Cardiopulmonary Rehabilitation, Structured Pacing, Education, Usual Care
Duke University, National Heart, Lung, and Blood Institute (NHLBI)
Long COVID, Long Covid19, Long Covid-19
10/25
01/26
TEAAMS, NCT05516537: Examining the Effects of a Remotely-delivered, Racially-tailored Exercise Training Program for Immediate and Sustained Improvements in Walking Dysfunction, Symptoms, and Health-related Quality of Life (HRQOL) Among African-Americans With Multiple Sclerosis (MS) Residing in Rural Environments.

Recruiting
N/A
100
US
Guidelines for Exercise in Multiple Sclerosis (GEMS), FLEX Stretching and Toning Program
University of Illinois at Chicago, University of Alabama at Birmingham, Bristol-Myers Squibb
Multiple Sclerosis
08/25
08/26
BIPAMS-Cog, NCT04518657: Internet-Delivered Lifestyle Physical Activity Intervention for Cognitive Processing Speed in Multiple Sclerosis

Recruiting
N/A
280
US
Behavioral Intervention for Physical Activity in MS (BIPAMS), Wellness for MS (WellMS)
University of Illinois at Chicago, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Multiple Sclerosis
10/25
07/26
FERLAMS, NCT05998616: Feasibility of Remote Exercise Training for Hispanics/Latinos With MS

Recruiting
N/A
50
US
Exercise Training Program, Flexibility Program
University of Illinois at Chicago
Multiple Sclerosis
06/25
07/25
LifePD, NCT06603012: Behavioral Intervention for Lifestyle Physical Activity in Parkinson's Disease

Not yet recruiting
N/A
50
US
GET Up PD, Stretching and Flexibility
University of Illinois at Chicago, National Institute on Aging (NIA)
Parkinson Disease (PD)
01/26
01/26
METS in MS, NCT05051618: Exercise Training for Managing Major Depressive Disorder in Multiple Sclerosis

Recruiting
N/A
146
US
POWER-MS, FLEX-MS
University of Illinois at Chicago, Congressionally Directed Medical Research Programs
Multiple Sclerosis, Major Depressive Disorder
03/25
03/25
ROME, NCT04088708: Gut Microbe Composition, Exercise, and Breast Breast Cancer Survivors

Recruiting
N/A
126
US
Aerobic Exercise Training, Attention Control
University of Alabama at Birmingham, National Cancer Institute (NCI)
Breast Cancer, Gut Microbiome, Exercise, Fatigue
08/25
08/25
Page, David
CA209-8H3, NCT03650894: Nivolumab, Ipilimumab, and Bicalutamide in Human Epidermal Growth Factor (HER) 2 Negative Breast Cancer Patients

Active, not recruiting
2
30
US
Nivolumab, Opdivo, Ipilimumab, Yervoy, Bicalutamide, Casodex
Providence Health & Services, Bristol-Myers Squibb, Memorial Sloan Kettering Cancer Center
Breast Neoplasm Female, Breast Cancer, Breast Carcinoma, Breast Tumor
01/25
01/26
NCT03546686: Peri-Operative Immune Checkpoint Inhibition and Cryoablation in Women with Triple-negative Breast Cancer

Recruiting
2
80
US
Pembrolizumab, Core Biopsy/Cryoablation, Breast Surgery, Ipilimumab, Nivolumab
University of Texas Southwestern Medical Center, Susan G. Komen Breast Cancer Foundation, Bristol-Myers Squibb, Boston Scientific Corporation, American Society of Clinical Oncology
Breast Cancer
06/26
06/28
NeoIRX, NCT04373031: Pembrolizumab, IRX-2, and Chemotherapy in Triple Negative Breast Cancer

Active, not recruiting
2
12
US
Pembrolizumab, KEYTRUDA, IRX 2
Providence Health & Services, Merck Sharp & Dohme LLC, Brooklyn ImmunoTherapeutics, LLC
Breast Cancer, Breast Neoplasms
07/23
06/25
neoHIP, NCT03747120: Neoadjuvant Her2-targeted Therapy and Immunotherapy With Pembrolizumab

Active, not recruiting
2
138
US
Paclitaxel, Taxol, Trastuzumab, Herceptin, Pertuzumab, Perjeta, Pembrolizumab, Keytruda
University of Texas Southwestern Medical Center, Merck Sharp & Dohme LLC, Breast Cancer Research Foundation
HER2-positive Breast Cancer, Breast Cancer
11/24
12/29
NCT06353997: Neoadjuvant INBRX-106 (Hexavalent OX40 Agonist) in Combination With Pembrolizumab as a Chemotherapy-sparing Regimen for Stage II TNBC (Triple Negative Breast Cancer) Patients

Recruiting
2
12
US
Pembrolizumab, KEYTRUDA, INBRX-106
Providence Health & Services, Inhibrx Biosciences, Inc
Triple Negative Breast Cancer
06/27
06/29
2019-101826, NCT04896320: Tucatinib With Chemotherapy and Trastuzumab in Advanced Her-2-neu Overexpressing, Previously Treated Breast Cancer.

Withdrawn
1/2
40
US
Tucatinib
Providence Health & Services, Seagen Inc.
Breast Cancer Stage IV
06/23
06/23
NCT02734290: Standard of Care Chemotherapy Plus Pembrolizumab for Breast Cancer

Active, not recruiting
1/2
29
US
Pembrolizumab, Keytruda, Paclitaxel, Taxol, Capecitabine, Xeloda
Providence Health & Services, Merck Sharp & Dohme LLC
Triple Negative Breast Cancer
08/19
12/25
NCT02950259: Pre-operative IRX-2 in Early Stage Breast Cancer (ESBC)

Active, not recruiting
1
16
US
Cyclophosphamide, Cytoxan, Indomethacin, Indocin, Omeprazole, Prilosec, Multivitamin, Vitamin
Providence Health & Services, Brooklyn ImmunoTherapeutics, LLC
Breast Neoplasm, Breast Neoplasm, Male, Triple Negative Breast Cancer
05/19
12/24
NCT04895761: Neoadjuvant DPX-Survivac Aromatase Inhibition, Radiotherapy or Cyclophosphamide in HR+HER2- Breast Cancer

Active, not recruiting
1
6
US
DPX-Survivac, Letrozole 2.5mg, Femara, Cyclophosphamide 50mg, cytoxan, XRT 10Gy x2
Providence Health & Services
Breast Cancer
06/23
09/26
NCT04879849: A Study of TAK-676 With Pembrolizumab After Radiation Therapy to Treat a Number of Cancers

Completed
1
34
US
Pembrolizumab, TAK-676, Image-guided radiation therapy
Takeda
Carcinoma, Non-Small-Cell Lung, Triple Negative Breast Neoplasms, Squamous Cell Carcinoma of Head and Neck
04/24
04/24
NCT03289364: Penguin Cold Caps in the Prevention of Hair Loss in Breast Cancer Patients

Active, not recruiting
N/A
9
US
Penguin Cold Caps
Providence Health & Services, Medical Specialties of California
Breast Cancer
01/21
01/23
SCS T2P, NCT05659836: Spinal Cord Stimulation Trial to Permanent Prediction

Completed
N/A
28
US
Abbott SCS Systems
Abbott Medical Devices
Chronic Pain
06/23
06/23
NCT04509115: Variation in Opioid Prescribing and Use for Acute Pain in Diverse Populations

Completed
N/A
1709
US
Short-acting opioid prescription for acute pain
Yale University, Food and Drug Administration (FDA)
Opioid Use, Opioid Prescribing
11/23
11/23
NCT05508984: Clinical Outcomes and Patient Satisfaction With Use of the Amma System

Active, not recruiting
N/A
15
US
Amma Cooling Caps
Providence Health & Services, Cooler Heads
Breast Cancer
01/24
12/24
Morgan, Douglas R
NCT04114006: Novel Screening Modality for Early Gastric Cancer

Completed
N/A
120
RoW
University of Alabama at Birmingham
Gastric Cancer
03/23
03/23
NCT05028296: Novel Mucosal Sampling Technology for Gastric Neoplasia: Wide-area Trans-epithelial Gastric Sampling for the Detection of Premalignant Lesions and Early Gastric Cancer

Not yet recruiting
N/A
300
US
WATS Sampling
University of Alabama at Birmingham
Gastric Cancer
12/23
12/24
COOP, NCT05612347: Colonoscopy vs Stool Testing for Older Adults With Colon Polyps

Recruiting
N/A
8946
US
FIT, Colonoscopy
Dartmouth-Hitchcock Medical Center, Patient-Centered Outcomes Research Institute
Colorectal Polyp, Colorectal Neoplasms, Colorectal Adenoma, Colorectal Cancer, Digestive System Disease
05/30
12/35
 

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