| Hitzel, Anne |
| Recruiting | 3 | 152 | Europe | SPECT, PET | Zionexa | Parkinson Disease, Essential Tremor | 09/24 | 12/24 | | |
| VELLAS, Bruno |
LO-MAPT, NCT03691519: Prevention of Cognitive Decline in Older Adults With Low Dha/Epa Index in Red Blood Cells |
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| Completed | 3 | 774 | Europe | Omega-3 treatment, Dietary intervention, Placebo | University Hospital, Toulouse | Alzheimer Disease | 03/20 | 03/20 | | |
PERSON-AL, NCT04820127: Personalized Management of Psycho-behavioral Symptoms in Alzheimer's Disease: Impact on Health Resources Use |
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| Recruiting | N/A | 668 | Europe | personalized care preceded by a standardized assessment | University Hospital, Toulouse | Alzheimer's Disease | 10/24 | 10/24 | | |
ICOPE Fr, NCT06676839: Effectiveness of the WHO ICOPE (Integrated Care for Older People) Program in Preventing Age-related Functional Decline: a 36-month Randomized Controlled Trial with a 24-month Extension: (ICOPE Trial.Fr) |
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| Recruiting | N/A | 1000 | Europe | the complete ICOPE program | University Hospital, Toulouse | Ageing | 10/31 | 10/31 | | |
| Active, not recruiting | N/A | 345 | Europe | MRI and PET scan | University Hospital, Toulouse, MSDAVENIR | Frail Elderly | 01/26 | 12/26 | | |
| Recruiting | N/A | 1000 | Europe | The Inspire Bio-resource Research Platform for Healthy Aging | University Hospital, Toulouse, European Regional Development Fund | Biological Aging | 10/31 | 10/33 | | |
| PLAT, Geneviève |
CAALL-F01, NCT02716233: A French Protocol for the Treatment of Acute Lymphoblastic Leukemia (ALL) in Children and Adolescents |
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| Recruiting | 3 | 1578 | Europe | pegaspargase 1250 IU/m2 x 2, ONCASPAR 1250 IU/m2 x 2, pegaspargase 2500 IU/m2 x 1, ONCASPAR 2500 IU/m2 x 1 | Assistance Publique - Hôpitaux de Paris, Shire | Acute Lymphoblastic Leukemia | 04/26 | 04/26 | | |
| Plaisance, Patrick |
HIFLOWED, NCT04607967: HFNO or Conventional Oxygen Therapy for Patients With Acute Hypoxemic Respiratory Distress |
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| Recruiting | N/A | 500 | Europe | High Flow Nasal Oxygen, HNFO (High Flow Nasal Oxygen) | Centre Hospitalier Universitaire de Besancon, Centre Hospitalier Universitaire Dijon, centre Hospitalier Intercommunal de Vesoul, Centre Hospitalier Universitaire de Saint Louis APHP, Poitiers University Hospital, University Hospital, Clermont-Ferrand, Rennes University Hospital, Centre Hospitalier of Chartres, University Hospital, Toulouse, University Hospital, Montpellier | Acute Hypoxemic Respiratory Distress | 05/25 | 06/25 | | |
| BREFEL-COURBON, Christine |
| Active, not recruiting | 3 | 134 | Europe | Apomorphine, Apokinon, Best Medical Treatment | Rennes University Hospital | Parkinson's Disease | 12/23 | 01/25 | | |
NCT03940872: Primary Parkinsonian Pain Diagnostic Questionnaire: Development and Validation of This Questionnaire |
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| Completed | N/A | 227 | Europe | Self-questionnaire 3PDQ | University Hospital, Toulouse | Parkinson Disease | 12/22 | 12/22 | | |
| Completed | N/A | 30 | Europe | reflexology massage, sham massage | University Hospital, Toulouse | Parkinson Disease | 05/23 | 05/23 | | |
GlutaTour, NCT03681795: Exploration of Glutamatergic System With PET Radiotracer in Gilles de la Tourette Patients: Pilot Study |
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| Recruiting | N/A | 24 | Europe | Experimental MRI exam and PET scan exam with radiotracer | University Hospital, Toulouse | Tourette Syndrome | 12/23 | 12/24 | | |
| Recruiting | N/A | 100 | Europe | CSF, blood and urine sampling, clinical measures of disease severity and progression | University Hospital, Bordeaux | Parkinsonian Syndromes, Parkinson's Disease, Multiple System Atrophy, Progressive Supranuclear Palsy | 12/23 | 12/25 | | |
| Completed | N/A | 100 | Europe | TCI, BPI, CPAQ-8, SF-MPQ, King's Parkinson's Disease Pain Scale (KPPS), Hospital Anxiety and Depression scale (HAD) questionary, PCS, ORT, Social Support Questionnaire (SSQ6), IPQ-R, WCC-R | University Hospital, Toulouse | Parkinson Disease | 04/24 | 04/24 | | |
PD-Pain, NCT06008704: Pain in Parkinson's Disease: Exploration of the Serotonin System in Positron Emission Tomography (PET [18F]-MPPF) |
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| Recruiting | N/A | 34 | Europe | Clinical assessment, Pain characteristics assessment, MRI, Thermotest, UPDRS-III Scale, [18F]-MPPF PET scan | University Hospital, Toulouse | Parkinson Disease | 09/26 | 09/26 | | |
| Boissezon, Xavier D de |
MODEX, NCT04253522: Modulation and Assessment of Mental Flexibility in Dysexecutive Brain Patients |
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| Terminated | N/A | 16 | Europe | Cognitive training | University Hospital, Toulouse, ISAE-SUPAERO | Dysexecutive Syndrome | 12/22 | 12/22 | | |
RéFEx, NCT04855903: Executive Functions Computerized Rehabilitation Using Virtual Reality to Improve Activities of Daily Living Post-stroke |
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| Recruiting | N/A | 27 | Europe | Covirtua Cognition software | University Hospital, Toulouse, Ministry of Health, France | Stroke | 04/25 | 04/25 | | |
| Gourdy, Pierre |
| Completed | 4 | 282 | Europe, US, RoW | Tirzepatide, LY3298176, Dulaglutide, LY2189265 | Eli Lilly and Company | Type 2 Diabetes | 07/24 | 08/24 | | |
NCT06383390: The Effect of Retatrutide Once Weekly on Cardiovascular Outcomes and Kidney Outcomes in Adults Living With Obesity (TRIUMPH-Outcomes) |
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| Recruiting | 3 | 10000 | Europe, Canada, US, RoW | Retatrutide, LY3437943, Placebo | Eli Lilly and Company | Atherosclerotic Cardiovascular Disease (ASCVD), Chronic Kidney Disease (CKD) | 02/29 | 02/29 | | |
| Active, not recruiting | 3 | 15374 | Europe, Canada, Japan, US, RoW | Tirzepatide, LY3298176, Placebo | Eli Lilly and Company | Obesity, Overweight | 10/27 | 10/27 | | |
| Completed | N/A | 130 | Europe | Glycemia estimated by exhaled air analyzer, Questionnaire, Veinous glycemia, Capillary glycemia, constitution biological collection, Blood sample, Test meal | University Hospital, Toulouse | Diabetes Mellitus, Type 2 | 02/23 | 02/23 | | |
STEATO-POMPE, NCT04270656: Liver and Metabolic Effects of Insulin Pump Therapy in Diabetics Type 2 with Non-alcoholic Hepatic Steatosis |
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| Completed | N/A | 46 | Europe | Insulin pump therapy, Multi-injection treatment ( MDI ). | Nantes University Hospital, University Hospital, Angers | Type 2 Diabetes (T2D) | 09/24 | 09/24 | | |
ACTIDIANE, NCT03184662: Efficacy of a High-intensity Physical Activity Program on Renal Function in High Risk Patients With Type 2 Diabetes |
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| Recruiting | N/A | 300 | Europe | HIPA, Counseling PA | Poitiers University Hospital, University Hospital, Bordeaux, University Hospital, Clermont-Ferrand, Centre Hospitalier Universitaire Dijon, Centre Hospitalier Universitaire de Besancon, Hopital Lariboisière, Bichat Hospital, Centre Hospitalier Sud Francilien, University Hospital, Lille, Centre Hospitalier Universitaire de Nice, University Hospital, Caen, University Hospital, Toulouse, University Hospital, Tours, Nantes University Hospital, Groupe Hospitalier Pitie-Salpetriere, Hospices Civils de Lyon, University Hospital, Montpellier, University Hospital, Strasbourg, Central Hospital, Nancy, France, HOSPITAL, CHARTRES, University of Liege | Type2 Diabetes, Diabetic Kidney Disease | 09/23 | 12/23 | | |
GAP OUEST, NCT06185491: Assessment of HGI (Hemoglobin Glycation Index) Variability Over Time in Patients Living with Diabetes Using Continuous Glucose Monitoring ( ) |
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| Recruiting | N/A | 750 | Europe | HGI | Nantes University Hospital | Diabetes Mellitus | 09/27 | 09/27 | | |
BOYDSENSE DATA, NCT06614101: Study Enabling the Collection of Clinical Data Necessary for the Second Phase of Development of the Glycemic Measurement Device by Analysis of Exhaled Air |
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| Recruiting | N/A | 235 | Europe | Exhaled air analysis | University Hospital, Toulouse | Type 2 Diabetes | 05/26 | 05/26 | | |
GLUCOGEN, NCT06570278: Role of High-Throughput Whole Genome Sequencing for the Diagnosis and Care of Atypical Diabetes |
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| Recruiting | N/A | 1020 | Europe | WGS coupled with MCM | Institut National de la Santé Et de la Recherche Médicale, France, Commissariat A L'energie Atomique, Rennes University Hospital, Central Hospital, Nancy, France, Nantes University Hospital, Imagine Institute, APHP, Hospices Civils de Lyon, Université Lumière Lyon 2, Toulouse University Hospital | Diabetes Mellitus | 11/31 | 11/34 | | |
| Recruiting | N/A | 348 | Europe | DBLG1 System | Diabeloop | Type1diabetes | 07/25 | 01/26 | | |
| Recruiting | N/A | 850 | Europe | Freestyle Libre Pro iQ | University Hospital, Montpellier | Acute Coronary Syndrome, Continuous Glucose Measurement, Glycemic Variability, Cardiovascular Event | 05/26 | 05/26 | | |
| Recruiting | N/A | 1000 | Europe, RoW | | University Hospital, Bordeaux, Fondation Francophone pour la Recherche sur le Diabete | Diabetic Foot Ulcer | 11/29 | 11/29 | | |
| LAPEYRE-MESTRE, Maryse |
| Recruiting | N/A | 10000 | Europe | | University Hospital, Toulouse | Addiction | 04/23 | 04/23 | | |
| Recruiting | N/A | 10000 | Europe | Medical information | University Hospital, Toulouse | Thrombocytopenia | 05/23 | 05/23 | | |
| PAUL, Carle |
METVI, NCT04237103: Combination of Methotrexate and Phototherapy Versus Phototherapy in Adults with Progressive Vitiligo |
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| Recruiting | 2 | 45 | Europe | Methotrexate, narrow-band UVB phototherapy, Placebos | University Hospital, Bordeaux | Vitiligo | 10/25 | 10/25 | | |
PREPCOV, NCT04481633: Efficacy of Pre-exposure Treatment With Hydroxy-Chloroquine on the Risk and Severity of COVID-19 Infection |
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| Recruiting | N/A | 800 | Europe | COVID 19 serology, COVID 19 Self-Questionnaire | University Hospital, Toulouse | COVID-19 | 03/22 | 03/22 | | |
ADlupus, NCT06506214: Characterizing Adherence to Treatment and Satisfaction With Care in Patients With Cutaneous Lupus |
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| Recruiting | N/A | 233 | Europe | Questionnaires | University Hospital, Toulouse | Cutaneous Lupus | 10/24 | 10/24 | | |
| Sailler, Laurent |
NCT05123586: A IMMA Master Protocol: A Study of LY3361237 in Participants With at Least Moderately Active Systemic Lupus Erythematosus |
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| Terminated | 2 | 85 | Europe, US, RoW | LY3361237, Placebo | Eli Lilly and Company | Systemic Lupus Erythematosus | 12/23 | 12/23 | | |
PREPCOV, NCT04481633: Efficacy of Pre-exposure Treatment With Hydroxy-Chloroquine on the Risk and Severity of COVID-19 Infection |
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| Recruiting | N/A | 800 | Europe | COVID 19 serology, COVID 19 Self-Questionnaire | University Hospital, Toulouse | COVID-19 | 03/22 | 03/22 | | |
LES-HYDROXY, NCT06161363: Description of Compliance With Hydroxychloroquine Treatment in Patients With Systemic Lupus Erythematosus |
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| Recruiting | N/A | 50 | Europe | The Morisky Medication Adherence Scale | University Hospital, Toulouse | Lupus Erythematosus | 12/24 | 12/24 | | |
| GEERAERTS, Thomas |
OPTIMIL, NCT04282629: Cerebral Hemodynamic Optimization by Milrinone to Prevent Delayed Cerebral Ischemia |
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| Recruiting | 2 | 234 | Europe | Milrinone Injection, Placebo | University Hospital, Toulouse | Aneurysmal Subarachnoid Hemorrhage | 07/25 | 07/25 | | |
DETERMINE, NCT04352296: Effect of Individualized Versus Standard Bp Management During MT for Anterior Ischemic Stroke |
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| Completed | N/A | 433 | Europe | Individualized blood pressure, Standard blood pressure | Fondation Ophtalmologique Adolphe de Rothschild, Ministry of Health, France | Acute Cerebrovascular Accident | 01/24 | 01/24 | | |
| Recruiting | N/A | 62 | Europe | alveolar recruitment maneuvers group 1, alveolar recruitment maneuvers group 2 | University Hospital, Toulouse | Cerebral Injuries, Acute Respiratory Distress Syndrome (ARDS) | 12/25 | 12/25 | | |
| Recruiting | N/A | 660 | Europe | Extubation readiness clinical score, Standard of care | University Hospital, Clermont-Ferrand, AZUREA Network (www.azurea.org), ANARLF Network, Direction Générale de l'Offre de Soin (DGOS) | Mechanical Ventilator Weaning, Acute Brain Injury, Altered Level of Consciousness, Mechanical Ventilation, Airway Control | 02/27 | 10/27 | | |
| Payoux, Pierre |
| Completed | N/A | 30 | Europe | reflexology massage, sham massage | University Hospital, Toulouse, Institut National de la Santé Et de la Recherche Médicale, France | Musculoskeletal Manipulations | 05/21 | 05/21 | | |
| Recruiting | N/A | 60 | Europe | Cerebral neuroinflammation evaluation | University Hospital, Toulouse, Institut National de la Santé Et de la Recherche Médicale, France | Depressive Disorder | 01/24 | 01/24 | | |
| Recruiting | N/A | 100 | Europe | MRI, eye-tracking, cognitive exams | University Hospital, Toulouse | Aging | 07/26 | 12/26 | | |
| BUREAU, Christophe |
ProPILARifax, NCT03069131: Two Strategies of Primary Prophylaxis of Spontaneous Bacterial Peritonitis in Severe Cirrhotic Patients With Ascites |
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| Completed | 3 | 160 | Europe | Rifaximin, Placebo | Centre Hospitalier Universitaire de Besancon, Alfasigma S.p.A., LC2 PHARMA | Cirrhosis, Ascites, Peritonitis | 06/22 | 03/23 | | |
NATiV3, NCT04849728: A Phase 3 Study Evaluating Efficacy and Safety of Lanifibranor Followed by an Active Treatment Extension in Adult Patients With (NASH) and Fibrosis Stages F2 and F3 ( ) |
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| Recruiting | 3 | 1000 | Europe, Canada, US, RoW | IVA337, Lanifibranor, Placebo | Inventiva Pharma | NASH - Nonalcoholic Steatohepatitis | 09/25 | 09/26 | | |
DHELIVER, NCT04229901: Study to Evaluate the Efficacy and Safety of HepaStem in Patients With Acute on Chronic Liver Failure (ACLF) |
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| Terminated | 2 | 133 | Europe, RoW | HepaStem, Placebo | Cellaion SA | Acute on Chronic Liver Failure | 05/24 | 05/24 | | |
| Recruiting | 2 | 50 | Europe, US | INT-787, Placebo | Intercept Pharmaceuticals, Intercept Pharmaceuticals, Inc. | Alcohol Associated Hepatitis | 12/24 | 03/25 | | |
NCT03695796: French Cohort for the Study of Non-invasive Tests of Liver Lesions in NAFLD/NASH (FreSH Cohort) |
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| Recruiting | N/A | 1000 | Europe | biopsy-proven NAFLD patients with non-invasive tests of liver fibrosis (blood tests, elastography devices) and biobank | University Hospital, Angers | NAFLD | 11/24 | 12/24 | | |
ARIAPUMP, NCT03506893: Medical-economic Evaluation of the Care of Refractory Ascites by Implantation of Alfapump® Device in Cirrhotic Patients |
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| Recruiting | N/A | 90 | Europe | Alphapump, Ascites puncture | University Hospital, Grenoble | Ascites, Paracentesis, Cirrhosis | 12/22 | 12/25 | | |
| Completed | N/A | 104 | Europe | Transjugular Portosytemic Shunt (TIPS), glue obliteration | Centre Hospitalier Universitaire de Besancon | Bleeding Gastric Varices, Cirrhosis | 03/23 | 02/24 | | |
POEME, NCT05206487: Hepatic Encephalopathy Prevention With Polydextrose After TIPS: Pilot Study |
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| Recruiting | N/A | 30 | Europe | Polydextrose | University Hospital, Toulouse, Société nationale française de gastro-entérologie | Hepatic Encephalopathy | 06/25 | 06/25 | | |
Quali-SAT, NCT04779593: Impact of Transferrin Saturation Guided Maintenance Treatment on Quality of Life in HFE Haemochromatosis |
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| Recruiting | N/A | 240 | Europe | Clinical examination, SF36 questionnaire, AIMS2_SF questionnaire, WOMAC questionnaire, EQ-5D-5L questionnaire, Blood Sample Complete blood count, Blood Sample Iron panel, Blood Sample Fasting Glucose, Blood sample lipid panel, Blood sample liver panel, Blood sample C reactive protein, Bloodletting - control group, BioBank, Medico-economical, Bloodletting - experimental group | Rennes University Hospital | Haemochromatosis | 01/27 | 01/27 | | |
| Not yet recruiting | N/A | 150 | Europe | Corticosteroid therapy | Assistance Publique - Hôpitaux de Paris | Liver Failure, Acute, Hepatitis, Autoimmune, Organ Dysfunction Scores, Risk Factors | 05/27 | 06/28 | | |
NCT04615091: Non-invasive Methods and Surgical Risk Stratification in Cirrhotics Undergoing Elective Extrahepatic Surgery |
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| Recruiting | N/A | 250 | Europe, Canada, US, RoW | | Azienda Ospedaliera Universitaria Integrata Verona | Advanced Chronic Liver Disease, Surgery--Complications | 10/21 | 08/22 | | |
| Thalamas, Claire |
CORELIA, NCT03464344: Cortical Superficial Siderosis and Risk of Recurrent Intracerebral Hemorrhage in Cerebral Amyloid Angiopathy. |
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| Recruiting | N/A | 170 | Europe | neurological, neuropsychological and MRI evaluation | University Hospital, Toulouse | Cerebral Amyloid Angiopathy | 02/23 | 02/25 | | |
| Recruiting | N/A | 62 | Europe | Overnight polysomnography, blood sample, high-resolution MRI scan, neuropsychological evaluation | University Hospital, Toulouse, Centre de Recherches sur la Cognition Animale (CRCA - UMR5169 CNRS/UPS), Centre de Recherche Cerveau & Cognition (CerCo - UMR5549 CNRS/UPS), Toulouse NeuroImaging Center (ToNIC - UMR 1214 Inserm/UPS), Fondation Plan Alzheimer, IHNPS/FHU HoPeS | Alzheimer Disease, Early Onset | 06/23 | 06/23 | | |
| Recruiting | N/A | 60 | Europe | Cerebral neuroinflammation evaluation | University Hospital, Toulouse, Institut National de la Santé Et de la Recherche Médicale, France | Depressive Disorder | 01/24 | 01/24 | | |
| MINVILLE, Vincent |
| Recruiting | N/A | 702 | Europe | No ventilation with face mask, Ventilation with face mask | Nantes University Hospital | Morbid Obesity, Ventilation Therapy; Complications | 09/25 | 09/25 | | |
OPTI-TWO, NCT05893030: Prevention of Organ Dysfunction and Mortality by Monitoring the Administration of Opioids and Hypnotics in Patients at High Postoperative Risk |
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| Recruiting | N/A | 1132 | Europe | anesthesia guided by sedation and analgesia monitoring, anesthesia performed according only to the clinical judgment of the anesthetist as usual practice | Centre Hospitalier Universitaire de Saint Etienne, Direction Générale de l'Offre de Soins | Sedation and Analgesia Monitoring | 01/27 | 12/27 | | |
| MAURY, Philippe |
| Recruiting | 2 | 120 | Europe | Spironolactone, Placebo | Hospices Civils de Lyon | Arrhythmogenic Right Ventricular Dysplasia | 12/27 | 12/29 | | |
FA2CM-DVDA, NCT03177018: DNA Analysis From Isolated Cardiomyocytes in the Molecular Diagnosis of Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia |
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| Completed | N/A | 34 | Europe | Cardiomyocytes collection | University Hospital, Toulouse | Arrhythmogenic Right Ventricular Dysplasia, Arrhythmogenic Right Ventricular Cardiomyopathy | 02/18 | 12/18 | | |
OPALE, NCT03058185: Observatoire Des Patients Atteints de Laminopathies et Emerinopathies (Observatory for PAtients With Laminopathies and Emerinopathies) |
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| Recruiting | N/A | 800 | Europe | | Pitié-Salpêtrière Hospital, Institute of Myology, Assistance Publique - Hôpitaux de Paris, Institut National de la Santé Et de la Recherche Médicale, France | Laminopathies, Emerinopathies | 07/33 | 07/33 | | |
| Recruiting | N/A | 80 | Europe | Peripheral immunological assessment on venous blood, Immunological assessment carried out on intracardiac material | University Hospital, Toulouse | Arrhythmogenic Right Ventricular Dysplasia | 02/26 | 02/26 | | |
| Recruiting | N/A | 20 | Europe | high resolution cartography | University Hospital, Toulouse | Atrioventricular Nodal Reentry Tachycardia, Supraventricular Tachycardia | 12/26 | 12/26 | | |
| Active, not recruiting | N/A | 292 | Europe, RoW | PVI using PEF, PVI using CFRF | University Hospital, Bordeaux, Funding: European Commission (H2020) | Atrial Fibrillation | 02/25 | 02/25 | | |
VIVA, NCT06294028: International Multicenter Project Comparing Radiofrequency Ablation Versus Implantable Defibrillator After Well-tolerated Ventricular Tachycardia in Ischemic Heart Disease with Minimally Impaired Ejection Fraction |
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| Recruiting | N/A | 268 | Europe | Adverse events collection, Quality of life questionnaire EQ-5D-5L, Medical-economic evaluation | University Hospital, Toulouse | Ischemic Heart Disease, Ventricular Tachycardia | 12/29 | 12/29 | | |
| Completed | N/A | 119 | Europe | image-guided VT ablation strategy, conventional VT ablation strategy | University Hospital, Bordeaux, EIT Health | Ventricular Tachycardia | 12/23 | 12/24 | | |
| Recruiting | N/A | 78 | Europe, RoW | PVI and Linear lesion using PEF, PVI and Linear lesion using CFRF | University Hospital, Bordeaux, Horizon 2020 - European Commission | Atrial Fibrillation | 05/25 | 05/25 | | |
RESOUDRE, NCT06642168: Sudden Cardiac Arrest Related to Sport in Young and Value of the Genetic Assessment: a French Prospective Register |
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| Recruiting | N/A | 80 | Europe | Whole exome sequencing to detect myocardial genetic mutations (SCA group only) | Rennes University Hospital | Sudden Cardiac Arrest, Sudden Cardiac Death | 01/28 | 01/28 | | |
| Recruiting | N/A | 50 | Europe | Cardioneuroablation | University Hospital, Bordeaux | Syncope, Vasovagal, Bradycardia, Heart Arrest | 01/26 | 01/26 | | |
NCT03737929: Hybrid Therapy and Heart Team for Atrial Fibrillation |
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| Recruiting | N/A | 228 | Europe | Hybrid ablation, Percutaneous catheter ablation | University Hospital, Toulouse, AtriCure, Inc. | Atrial Fibrillation | 12/25 | 12/25 | | |
| Recruiting | N/A | 1800 | Europe, RoW | HD ECG, Conventional 12-lead ECG | University Hospital, Bordeaux | Ventricular Arrhythmias | 04/27 | 04/27 | | |
| OUSSET, Pierre-Jean |
| Terminated | 3 | 1027 | Europe, Canada, Japan, US, RoW | Aducanumab, BIIB037, Aducanumab-avwa, Aduhelm, Placebo | Biogen, Biogen Idec Research Limited | Alzheimer's Disease | 08/24 | 08/24 | | |
| Recruiting | 3 | 1500 | Europe, RoW | Donanemab, (LY3002813), Placebo | Eli Lilly and Company | Alzheimer Disease, Dementia, Brain Diseases, Central Nervous System Diseases, Nervous System Diseases, Tauopathies, Neurodegenerative Diseases, Neurocognitive Disorders, Mental Disorders | 04/27 | 04/27 | | |
| Recruiting | 2 | 282 | Europe, Canada, US, RoW | GSK4527226, Placebo | GlaxoSmithKline, Alector Inc. | Alzheimer's Disease | 12/26 | 02/29 | | |
CELIA, NCT05399888: A Study to Learn About the Safety of BIIB080 Injections and Whether They Can Improve Symptoms of Participants With Mild Cognitive Impairment Due to Alzheimer's Disease (AD) or Mild AD Dementia Between 50 to 80 Years of Age |
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| Active, not recruiting | 2 | 416 | Europe, Canada, Japan, US, RoW | BIIB080, ISIS 814907, BIIB080-matching placebo | Biogen | Mild Cognitive Impairment Due to Alzheimer's Disease, Alzheimer's Disease Dementia | 05/26 | 01/29 | | |
PERSON-AL, NCT04820127: Personalized Management of Psycho-behavioral Symptoms in Alzheimer's Disease: Impact on Health Resources Use |
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| Recruiting | N/A | 668 | Europe | personalized care preceded by a standardized assessment | University Hospital, Toulouse | Alzheimer's Disease | 10/24 | 10/24 | | |
| Recruiting | N/A | 1000 | Europe | | University Hospital, Toulouse, France Alzheimer | Alzheimer Disease | 06/26 | 01/27 | | |
| Voisin, Thierry |
PERSON-AL, NCT04820127: Personalized Management of Psycho-behavioral Symptoms in Alzheimer's Disease: Impact on Health Resources Use |
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| Recruiting | N/A | 668 | Europe | personalized care preceded by a standardized assessment | University Hospital, Toulouse | Alzheimer's Disease | 10/24 | 10/24 | | |
| Delrieu, Julien |
PERSON-AL, NCT04820127: Personalized Management of Psycho-behavioral Symptoms in Alzheimer's Disease: Impact on Health Resources Use |
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| Recruiting | N/A | 668 | Europe | personalized care preceded by a standardized assessment | University Hospital, Toulouse | Alzheimer's Disease | 10/24 | 10/24 | | |
| Recruiting | N/A | 108 | Europe | RGn600, RGn600 Sham | REGEnLIFE SAS, RCTs, University Hospital, Toulouse | Alzheimer Disease | 05/25 | 12/25 | | |
| Chauveau, Dominique |
| Recruiting | 3 | 272 | Europe | 56 days of weight-adjusted L-Carnitine treatment, 10 days of intravenous placebo (isotonic saline) | Centre Hospitalier Universitaire de Nīmes | Severe Sepsis, Shock, Septic, Acute Kidney Injury | 05/25 | 05/26 | | |
MASTER-ANCA, NCT03323476: Maintaining or Stopping Immunosuppressive Therapy in Patients with ANCA Vasculitis and End-stage Renal Disease |
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| Recruiting | 3 | 136 | Europe | Discontinuation (or not initiation) of Immunosuppressive Therapy, Maintenance (or initiation) of immunosuppressive treatment: Imurel®, Mabthera®,Cellcept®, Cortancyl® | Centre Hospitalier Departemental Vendee | Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis, End Stage Renal Disease | 03/31 | 03/31 | | |
NCT03804359: Personalized Medicine for Membranous Nephropathy |
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| Recruiting | 2 | 64 | Europe | Rituximab | Centre Hospitalier Universitaire de Nice | Idiopathic Membranous Nephropathy | 09/23 | 09/23 | | |
GYN-HNF1, NCT04746053: Ovarian Function and Gynecological Profile of Patients Carrying a Pathogenic Variant of the HNF1B Gene |
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| Completed | N/A | 26 | Europe | Pelvic ultrasound, blood sample | University Hospital, Toulouse | Genital Diseases, Female | 10/23 | 10/23 | | |
PREPCOV, NCT04481633: Efficacy of Pre-exposure Treatment With Hydroxy-Chloroquine on the Risk and Severity of COVID-19 Infection |
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| Recruiting | N/A | 800 | Europe | COVID 19 serology, COVID 19 Self-Questionnaire | University Hospital, Toulouse | COVID-19 | 03/22 | 03/22 | | |
| Huart, Antoine |
| Active, not recruiting | 2 | 40 | Europe | Daratumumab, Bortezomib Injection, velcade, Dexamethasone oral tablet | Stichting European Myeloma Network, Janssen Pharmaceutica | Light Chain (AL) Amyloidosis, Stage 3B | 01/25 | 01/25 | | |
IsAMYP, NCT05066607: Isatuximab Plus Pomalidomide and Dexamethasone Association for Patients With AL Amyloidosis Not in VGPR or Better After Any Previous Therapy |
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| Recruiting | 2 | 46 | Europe | Isatuximab, Pomalidomide, Dexamethasone | Intergroupe Francophone du Myelome, Sanofi, Bristol-Myers Squibb | AL Amyloidosis | 03/26 | 03/26 | | |
| SILVA, Stein |
| Completed | N/A | 7 | Europe | serology testing profiles description, biomarkers, immune response characterization, in vivo brain PET-TSPO acquisitions, brain MRI assessment, neurocognitive assessment | University Hospital, Toulouse, Institut National de la Santé Et de la Recherche Médicale, France | Covid19, Delirium, Post-traumatic Stress Disorder | 06/22 | 06/22 | | |
ARISE, NCT06617377: Combined Whole-brain Structural and Functional MRI for the Prediction of Neurological Recovery After Cardiac Arrest |
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| Not yet recruiting | N/A | 263 | NA | advanced whole-brain sMRI/fMRI/contrast-enhanced MRI scan | University Hospital, Toulouse | Coma, Cardiac Arrest, Disorder of Consciousness, Neurologic Disorder | 07/28 | 07/28 | | |
| GALITZKY, Monique |
| Recruiting | N/A | 62 | Europe | Overnight polysomnography, blood sample, high-resolution MRI scan, neuropsychological evaluation | University Hospital, Toulouse, Centre de Recherches sur la Cognition Animale (CRCA - UMR5169 CNRS/UPS), Centre de Recherche Cerveau & Cognition (CerCo - UMR5549 CNRS/UPS), Toulouse NeuroImaging Center (ToNIC - UMR 1214 Inserm/UPS), Fondation Plan Alzheimer, IHNPS/FHU HoPeS | Alzheimer Disease, Early Onset | 06/23 | 06/23 | | |
| VALTON, Luc |
Epi-FaR, NCT02491476: Recording "Fast Ripples" Using Microelectrodes During Stereo-encephalography in Patients With Drug-resistant Partial Epilepsy |
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| Completed | N/A | 54 | Europe | intracerebral micro-macroelectrodes | University Hospital, Toulouse, CerCo, CNRS Cerco UMR5549 CHU Purpan Toulouse France, DIXI Medical, Besançon, France | Epilepsy | 08/22 | 09/22 | | |
SPREAD, NCT03321240: Study of Predictive Biomarkers for Rational Management of Drug-resistant Epilepsy Associated With Focal Cortical Dysplasia |
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| Recruiting | N/A | 240 | Europe | visual and quantitative SEEG signal analysis, Resective epilepsy surgery procedure | University Hospital, Strasbourg, France | Refractory Epilepsy, Focal Epilepsy, Focal Cortical Dysplasia | 12/22 | 12/22 | | |
| Recruiting | N/A | 62 | Europe | Overnight polysomnography, blood sample, high-resolution MRI scan, neuropsychological evaluation | University Hospital, Toulouse, Centre de Recherches sur la Cognition Animale (CRCA - UMR5169 CNRS/UPS), Centre de Recherche Cerveau & Cognition (CerCo - UMR5549 CNRS/UPS), Toulouse NeuroImaging Center (ToNIC - UMR 1214 Inserm/UPS), Fondation Plan Alzheimer, IHNPS/FHU HoPeS | Alzheimer Disease, Early Onset | 06/23 | 06/23 | | |
| Recruiting | N/A | 160 | Europe | Epilepsy Surgery Satisfaction Questionnaire (ESSQ-19), Quality of Life in Epilepsy Inventory (QOLIE-31), Generalized Anxiety Disorder 7 (GAD7), Neurological Disorders Depression Inventory for Epilepsy (NDDI-E), Evaluation of Changes in Daily Life after Epilepsy Surgery (EVOCQUE) | University Hospital, Toulouse | Epilepsy | 12/24 | 12/24 | | |
| Recruiting | N/A | 140 | Europe | Choice of VNS set of parameters based on the lowest PLI, EEG | Assistance Publique Hopitaux De Marseille | Epilepsy | 06/25 | 12/26 | | |
GALVANI GS-3, NCT06334952: Efficacy of Personnalized Transcranial Direct Current Electrical Stimulation (tDCS) in Drug-resistant Epileptic |
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| Recruiting | N/A | 60 | Europe | transcranial direct current stimulation, Research MRI, EEG | Assistance Publique Hopitaux De Marseille, CRMBM-CEMEREM, Institut National de la Santé Et de la Recherche Médicale, France - LTSI, Neuroelectrics Corporation | Epilepsy, Drug Resistant Epilepsy | 12/26 | 11/27 | | |
REPREO, NCT05609084: Intensive Preoperative Speech Rehabilitation in Drug-Resistant Temporal Epilepsy |
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| Recruiting | N/A | 214 | Europe | Speech therapy, Speech therapy assessment | Assistance Publique Hopitaux De Marseille | Epilepsy, Anomia, Temporal Lobe Epilepsy | 03/27 | 11/27 | | |
NENUFAR, NCT06105645: Contribution of Fast-ripples to the Improvement of the Neurosurgical Management of Drug-refractory Epilepsy |
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| Recruiting | N/A | 440 | Europe | DIXI Medical Microdeep® Micro- Macro Depth electrodes, Standard electrodes | University Hospital, Toulouse, Centre de recherche Cerveau et Cognition (CERCO), Dixi Medical | Epilepsy | 04/30 | 04/30 | | |
