| Seguin, Philippe |
| Terminated | 2 | 92 | Europe, Japan, US, RoW | BIIB093, Glibenclamide, CIRARA, RP 1127, Placebo | Remedy Pharmaceuticals, Inc. | Brain Contusion | 06/23 | 06/23 | | |
| Not yet recruiting | N/A | 5000 | Europe | questionnaire filling | Centre Hospitalier Universitaire de NÄ«mes | Critical Illness, Covid19, Stress Disorders, Post-Traumatic | 09/22 | 09/22 | | |
| Recruiting | N/A | 770 | Europe | High flow Oxygenation, Standard oxygen | University Hospital, Brest | Chest Trauma, High Flow Oxygenation | 02/26 | 02/26 | | |
NCT02426255: Post Traumatic Critical Complications: a Prospective Cohort Study (ATLANREA) |
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| Recruiting | N/A | 5000 | Europe | Collection of medical data from ICU patients | Nantes University Hospital | Severe Trauma (With or Without Traumatic Brain Injury) | 01/50 | 01/50 | | |
| Belliard, Serge |
NCT03454646: Comparison of Therapeutic Strategies With Cholinesterase Inhibitors (SOS TRIAL) |
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| Not yet recruiting | 4 | 1205 | Europe | cholinesterase inhibitors (CI) (donepezil, galantamine or rivastigmine) | University Hospital, Bordeaux | Alzheimer Disease, Cholinesterase Inhibitors | 04/27 | 09/27 | | |
| Terminated | 3 | 1027 | Europe, Canada, Japan, US, RoW | Aducanumab, BIIB037, Aducanumab-avwa, Aduhelm, Placebo | Biogen, Biogen Idec Research Limited | Alzheimer's Disease | 08/24 | 08/24 | | |
| Completed | N/A | 40 | Europe | Metacognition tests | University Hospital, Grenoble | Semantic Dementia, Alzheimer Disease, Healthy | 04/22 | 04/22 | | |
| Recruiting | N/A | 40 | Europe | Mindfulness meditation training, Therapeutic education | Rennes University Hospital, Laboratoire Traitement du Signal et de l'Image, INSERM UMR1099 Rennes, Centre Hospitalier Guillaume Régnier, RENNES | Epilepsy | 03/23 | 03/23 | | |
| EDAN, Gilles |
NeurofilMS, NCT03981003: Serum Neurofilament-light Chain and GFAP Levels in Patients From the OFSEP Cohort at Different Landmarks of Multiple Sclerosis |
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| Recruiting | N/A | 1150 | Europe, RoW | Blood sample | Centre Hospitalier Universitaire de Nīmes, Hospices Civils de Lyon | Multiple Sclerosis | 06/28 | 06/28 | | |
| Recruiting | N/A | 1000 | Europe, RoW | No intervention | Hospices Civils de Lyon | Sclerosis, Multiple, Neuromyelitis Optica Spectrum Disorder, Myelin Oligodendrocyte Glycoprotein (MOG)-Antibody Related Disorders, Pregnancy Abnormal | 08/36 | 08/36 | | |
INESEP, NCT05017038: The Role of Social and Territorial Inequalities in the Management and Prognosis of Multiple Sclerosis |
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| Recruiting | N/A | 2000 | Europe | | Central Hospital, Nancy, France | Multiple Sclerosis, Social and Territorial Inequalities | 03/23 | 06/23 | | |
| Gandemer, Virginie |
CAALL-F01, NCT02716233: A French Protocol for the Treatment of Acute Lymphoblastic Leukemia (ALL) in Children and Adolescents |
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| Recruiting | 3 | 1578 | Europe | pegaspargase 1250 IU/m2 x 2, ONCASPAR 1250 IU/m2 x 2, pegaspargase 2500 IU/m2 x 1, ONCASPAR 2500 IU/m2 x 1 | Assistance Publique - Hôpitaux de Paris, Shire | Acute Lymphoblastic Leukemia | 04/26 | 04/26 | | |
TAK-620-2004, NCT05319353 / 2021-004279-15: A Study to Evaluate the Safety and Tolerability, Pharmacokinetics, and Antiviral Activity of Maribavir for the Treatment of Cytomegalovirus (CMV) Infection in Children and Adolescents Who Have Received a Hematopoietic Stem Cell Transplant (HSCT) or a Solid Organ Transplant (SOT) |
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| Active, not recruiting | 3 | 80 | Europe, Japan, US, RoW | Maribavir, TAK-620 | Takeda, Takeda Development Center Americas, Inc. | Cytomegalovirus (CMV) | 01/27 | 01/27 | | |
| Recruiting | 3 | 6430 | Europe, RoW | Omitted Doxorubicin, Omitted Vincristine+Dexamethasone pulses, Inotuzumab Ozogamicin+Standard Maintenance Therapy, Besponsa+Maintenance Therapy, Imatinib, 6-tioguanine+Standard Maintenance Therapy, Blinatumomab, Blincyto | Mats Heyman, The Swedish Research Council, The Swedish Childhood Cancer Foundation, Pfizer, Servier, NordForsk, Aamu Pediatric Cancer Foundation, German Society for Pediatric Oncology and Hematology GPOH gGmbH, Clinical Trial Center North (CTC North GmbH & Co. KG), Belgium Health Care Knowledge Centre, Karolinska Institutet, Cancer Research UK, Fundação Rui Osório de Castro, Acreditar - Associação de Pais e Amigos das Crianças com Cancro, Grupo Português De Leucemias Pediátricas, Amgen, Nova Laboratories Limited, Danish Child Cancer Foundation, Danish Cancer Society, The Novo Nordic Foundation, Assistance Publique - Hôpitaux de Paris, Direction Générale de l'Offre de Soins | Leukemia, Acute Lymphoblastic | 06/27 | 06/32 | | |
| Recruiting | 2/3 | 1800 | Europe, Canada, RoW | VP16, Etoposide, TBI, Thiotepa, Thio, Treosulfan, Treo, Fludarabine, Flu, Busulfan, Bu, ATG Thymoglobulin, ATG Thymo, Cyclophosphamide, Cy, Grafalon, Anti-human T-lymphocyte immunoglobulin | St. Anna Kinderkrebsforschung, ALL SCTped Forum, European Society for Blood and Marrow Transplantation, ALL-BFM Study Group, Assistance Publique - Hôpitaux de Paris, Dutch Childhood Oncology Group, Swiss Pediatric Oncology Group, Australian & New Zealand Children's Haematology/Oncology Group | Acute Lymphoblastic Leukaemia | 06/25 | 04/30 | | |
HAPLO-EMPTY, NCT05126849: Haploidentical Allogeneic Hematopoietic Stem Cell Transplantation With Post-transplant Cyclophosphamide in Patients With Acquired Refractory Aplastic Anemia or in Relapse After Immunosuppression |
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| Recruiting | 2 | 31 | Europe | Allogenic transplantation | Assistance Publique - Hôpitaux de Paris | Refractory Idiopathic Aplastic Anemia, Haploidentical Allogeneic Hematopoietic Stem Cell Transplantation | 01/27 | 01/27 | | |
NCT04501614 / 2019-002549-39: A Study of Ponatinib With Chemotherapy in Children, Teenagers, and Adults With Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia |
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| Terminated | 1/2 | 11 | Europe, US, RoW | Ponatinib, Chemotherapy Agents | Takeda, Takeda Development Center Americas, Inc. | Pediatric Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia (Ph+ALL), Ph+ Mixed Phenotype Acute Leukemia (MPAL), Philadelphia Chromosome-Like ALL (Ph-like ALL) | 12/23 | 07/24 | | |
NCT02938858: French Registry of First-line Treatment of Acute Promyelocytic Leukemia |
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| Recruiting | N/A | 400 | Europe | | Groupe Francophone des Myelodysplasies, Teva Pharmaceuticals USA | Acute Promyelocytic Leukemia | 10/20 | 10/22 | | |
| Recruiting | N/A | 16 | Europe, Japan, US, RoW | genetic restrospective study | Institut National de la Santé Et de la Recherche Médicale, France | Immune Deficiency, Autoimmune Diseases, Infections, Diagnosis | 08/26 | 01/27 | | |
| Not yet recruiting | N/A | 50 | Europe | Sampling bone tissue and blood | Rennes University Hospital | Leukemia, Lymphoblastic, Acute, Pediatric | 02/35 | 06/35 | | |
ALARM3, NCT05772559: Acute Myeloid Leukemia At Initial Diagnosis and/or Relapse in Children, Teenagers and Young Adults: Molecular Profiling, Multidrug Testing and MSC Interaction Studies |
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| Recruiting | N/A | 500 | Europe | Collection of blood sample of bone marrow (cohort 1), Collection of blood sample of bone marrow (cohort 2 and 3) | Assistance Publique - Hôpitaux de Paris | Acute Myeloid Leukemia, Genetic Predisposition to Disease | 05/33 | 05/33 | | |
GATA-2, NCT05983991: Study for Characterisation of Predictive Parameters of Clonal Evolution in Subjects With GATA2 Germline Mutation |
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| Recruiting | N/A | 150 | Europe | Biological samples (blood and bone marrow samples). | Institut Claudius Regaud | GATA2 Gene Mutation | 10/33 | 10/33 | | |
| LAINE, Fabrice |
CoviCompare_J, NCT05037266: Cohort Assessing the Immunogenicity and the Safety of the COVID-19 Vaccine Janssen in Healthy Volunteers Based on 2 Age Groups: 65 Years or Older - 55 to 65 Years. Covicompare-Janssen |
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| Active, not recruiting | 4 | 27 | Europe | COVID-19 Vaccine Janssen (Ad26.COV2-S) | Centre Hospitalier Universitaire de Saint Etienne | Healthy Volunteers | 02/22 | 12/24 | | |
| Recruiting | 2 | 318 | Europe | NFL-101 dose 1, Tobacco leaf extract, NFL-101 dose 2, Placebo, WFI | NFL Biosciences SAS | Smoking Cessation, Nicotine Dependence | 07/24 | 12/24 | | |
| Recruiting | N/A | 480 | Europe | Bone densitometry (BMD), Blood sampling for patients only | Centre Hospitalier Universitaire de Saint Etienne, Ministry of Health, France | Hemophilia | 12/24 | 03/25 | | |
CAP'Hospi, NCT05380193: Serotype Distribution in Hospitalized Adult with Pneumococcal Community Acquired Pneumonia in France |
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| Active, not recruiting | N/A | 2000 | Europe | | Institut National de la Santé Et de la Recherche Médicale, France | Pneumonia, Pneumococcal Infections, Community-acquired Pneumonia | 02/25 | 02/25 | | |
RESPIVAC, NCT05582239: Measure of Vaccine Effectiveness to Prevent Hospitalizations for Viral Respiratory Infections in Adults |
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| Recruiting | N/A | 2400 | Europe | | ANRS, Emerging Infectious Diseases, P95, I-REIVAC, EPICONCEPT, Institut de Recherche en Santé Publique, France | Severe Acute Respiratory Infection (SARI), Influenza, COVID-19 | 01/26 | 01/26 | | |
| MORANDI, Xavier |
| Recruiting | N/A | 1000 | Europe, Canada, US, RoW | Neurosurgery, Radiation therapy, Embolization | Centre hospitalier de l'Université de Montréal (CHUM), Centre Hospitalier Régional et Universitaire de Brest | Unruptured Brain Arteriovenous Malformation, Ruptured Brain Arteriovenous Malformation, Arteriovenous Malformations, AVM, BAVM | 01/35 | 01/36 | | |
| Pibarot, Philippe |
NCT01835028: Multicenter Prospective Study of Low-Flow Low-Gradient Aortic Stenosis (TOPAS Study) |
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| Recruiting | 3 | 320 | Europe, Canada, US | Echocardiography, Computed tomography, Magnetic resonance imaging, Blood biomarkers, Stress echocardiography | Laval University, University Hospital, Brest | Aortic Valve Stenosis | 01/24 | 01/24 | | |
| Recruiting | N/A | 250 | Canada | Doppler-echocardiography, Computed tomography, Magnetic resonance imaging, Fasting blood sample | Laval University, Canadian Institutes of Health Research (CIHR), Heart and Stroke Foundation of Canada | Aortic Valve Stenosis | 01/24 | 01/24 | | |
NCT01835054: Determinants of the Progression and Outcome of Mitral Regurgitation |
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| Recruiting | N/A | 440 | Europe, Canada | Blood biomarkers, DNA collection, Echocardiography, Cardiopulmonary exercise testing, Magnetic resonance imaging (MRI), Exercise stress doppler echocardiography, Holter ECG | Laval University, Canadian Institutes of Health Research (CIHR), Heart and Stroke Foundation of Canada, University Hospital, Brest | Mitral Valve Insufficiency | 03/24 | 03/24 | | |
| Guillet, Benoît |
| Completed | N/A | 54 | Europe | Vitamin K Antagonist - Drug, direct oral anticoagulant | Groupe Maladies hémorragiques de Bretagne | Hemophilia A, Hemophilia B, Anticoagulant-induced Bleeding | 12/21 | 12/21 | | |
| Completed | N/A | 361 | Europe | Desmopressin | Groupe Maladies hémorragiques de Bretagne | Carrier of Hemophilia A, Desmopressin, Factor VIII Deficiency | 01/23 | 04/23 | | |
SENIORHEMO, NCT05218772: Objective and Perceived Health Status of Elderly People With Moderate or Severe Haemophilia in France: an Ancillary Study of the FranceCoag Registry |
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| Recruiting | N/A | 612 | Europe | Questionnaires | Assistance Publique Hopitaux De Marseille | Moderate or Serious Haemophilia | 06/23 | 12/23 | | |
GIDEMHA, NCT05628558: Genetic Influence of Genetic Factors Influencing the Desmopressin's Efficacy in Mild/Moderate Hemophilia A |
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| Recruiting | N/A | 800 | Europe | Desmopressin, DDAVP | Groupe Maladies hémorragiques de Bretagne | Hemophilia A, Mild, Desmopressin, Factor VIII | 12/22 | 04/23 | | |
| Jezequel, Caroline |
NCT05330455: Study of GSK3965193 in Healthy Participants and Participants Living With Chronic Hepatitis B Infection |
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| Recruiting | 2 | 132 | Europe, Canada, RoW | GSK3965193, Placebo to match GSK3965193, Bepirovirsen | GlaxoSmithKline | Hepatitis B | 10/27 | 10/27 | | |
ARIAPUMP, NCT03506893: Medical-economic Evaluation of the Care of Refractory Ascites by Implantation of Alfapump® Device in Cirrhotic Patients |
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| Recruiting | N/A | 90 | Europe | Alphapump, Ascites puncture | University Hospital, Grenoble | Ascites, Paracentesis, Cirrhosis | 12/22 | 12/25 | | |
| Completed | N/A | 104 | Europe | Transjugular Portosytemic Shunt (TIPS), glue obliteration | Centre Hospitalier Universitaire de Besancon | Bleeding Gastric Varices, Cirrhosis | 03/23 | 02/24 | | |
| Recruiting | N/A | 800 | Europe | Blood draw for the laboratory assessment | ANRS, Emerging Infectious Diseases | Hepatitis D, Chronic, Hepatitis B, Chronic | 12/27 | 06/28 | | |
| FERRE, Jean-Christophe |
| Recruiting | N/A | 600 | Europe | MRI data acquiring in healthy volunteers | Rennes University Hospital | Healthy | 12/21 | 12/22 | | |
| Recruiting | N/A | 4000 | Europe | | Hopital Foch | Stroke, Acute | 12/22 | 12/22 | | |
pc-ASTER, NCT05320263: Contact Aspiration Versus Stent Retriever for Recanalisation of Acute Stroke Patients With Basilar Artery Occlusion: The Posterior Circulation ASTER Randomized Trial Protocol |
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| Recruiting | N/A | 480 | Europe | Contact aspiration Thrombectomy, Stent retriever thrombectomy | Hopital Foch | Basilar Artery Occlusion | 07/26 | 07/27 | | |
| Recruiting | N/A | 600 | Europe | MRI | Rennes University Hospital | MRI | 11/26 | 12/27 | | |
| ARNAUD, Alexis |
| Not yet recruiting | 2 | 50 | NA | Oxybutynin 1 mg/ml Syrup | University Hospital, Bordeaux | Male Urogenital Diseases | 09/23 | 09/23 | | |
LaparoDAN, NCT04174807: Prospective Study of Antenatal Diagnostic Criteria for Digestive Complications of Gastroschisis |
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| Recruiting | N/A | 200 | Europe, RoW | | University Hospital, Angers | Gastroschisis, Intestinal Occlusion | 05/22 | 05/22 | | |
NCT02812212: CTT on Renogram as an Early Marker of Significant Obstruction in Uretero-pelvic Junction Syndrome |
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| Recruiting | N/A | 75 | Europe | ultrasonography, diuretic renography | Centre Hospitalier Universitaire de la Réunion | Ureteropelvic Junction Obstruction | 11/26 | 04/27 | | |
| drapier, sophie |
LIGHTHOUSE, NCT05418673 / 2022-000747-77: A Study to Assess if BIIB122 Tablets Are Safe and Can Slow Worsening of Early-Stage Parkinson's Disease in Participants With Specific LRRK2 Genetic Variants Between the Ages of 30 and 80 Using the Movement Disorder Society-Unified Parkinson's Disease Rating Scale |
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| Terminated | 3 | 7 | Europe, US | BIIB122, DNL151, BIIB122-Matching Placebo | Biogen, Denali Therapeutics Inc. | Parkinson Disease | 07/23 | 07/23 | | |
| Recruiting | 3 | 152 | Europe | SPECT, PET | Zionexa | Parkinson Disease, Essential Tremor | 09/24 | 12/24 | | |
| Active, not recruiting | 3 | 134 | Europe | Apomorphine, Apokinon, Best Medical Treatment | Rennes University Hospital | Parkinson's Disease | 12/23 | 01/25 | | |
| Active, not recruiting | 2/3 | 110 | Europe, US | AMX0035, Placebo | Amylyx Pharmaceuticals Inc. | Progressive Supranuclear Palsy, PSP, Neurodegenerative Diseases, Atypical Parkinsonism | 04/26 | 11/29 | | |
PIMPARK, NCT03947216: Randomized Placebo Controlled Trial Evaluating the Efficacy of Pimavanserin, a Selective Serotonin 5-HydroxyTryptamine-2A (5HT2A) Inverse Agonist, to Treat Impulse Control Disorders in Parkinson's Disease. |
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| Completed | 2 | 117 | Europe | Active drug: pimavanserin 17mg (2 strength tablets), Placebo: 2 tablets containing same excipients except active compound, Assessment of severity of ICD (impulse control disorders), Assessment of motor and non-motors symptoms of PD Evaluation of hyper- and hypodopaminergic behaviors, Assessment of quality of life, Assessment of depression, Assessment of cognition, Assessment of severity of Parkinson Disease, Blood analysis, Cardiac monitoring | University Hospital, Strasbourg, France, NS-PARK, EUCLID Clinical Trial Platform, F-CRIN, ACADIA Pharmaceuticals Inc. | Parkinson Disease | 04/24 | 06/24 | | |
LUMA, NCT05348785 / 2021-004849-20: A Study to Learn About the Safety of BIIB122 Tablets and Whether They Can Slow the Worsening of Early-Stage Parkinson's Disease in Adults Between the Ages of 30 and 80 |
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| Recruiting | 2 | 640 | Europe, Canada, Japan, US, RoW | BIIB122, DNL151, BIIB122-Matching Placebo | Biogen, Denali Therapeutics Inc. | Parkinson Disease | 12/25 | 12/25 | | |
ACTIVATE, NCT05819359: Efficacy, Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of BIA 28-6156 in GBA-PD |
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| Active, not recruiting | 2 | 237 | Europe, Canada, US | BIA 28-6156 10 mg, BIA 28-6156 60 mg, Placebo | Bial R&D Investments, S.A. | Parkinson's Disease | 03/26 | 07/26 | | |
RETRO-PIMPARK, NCT06754553: Trial Evaluating the Efficacy of Pimavanserin, a Selective Serotonin 5-HydroxyTryptamine-2A (5HT2A) Inverse Agonist, to Treat Impulse Control Disorders in Parkinson's Disease. |
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| Not yet recruiting | N/A | 100 | Europe | Assessment of severity of ICD (impulse control disorders), Assessment of motor and non-motors symptoms of PD Evaluation of hyper- and hypodopaminergic behaviors, Assessment of quality of life, Assessment of depression, Assessment of cognition, Assessment of severity of Parkinson Disease, Cardiac monitoring | University Hospital, Strasbourg, France, NS-PARK Network, EUCLID Clinical Trial Platform, F-CRIN | Parkinson Disease | 02/26 | 02/26 | | |
PERSO-PERF, NCT06080399: Personality and Quality of Life Amelioration After Continuous Subcutaneous Apomorphine Infusion in Parkinson's Disease |
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| Recruiting | N/A | 70 | Europe | Continuous subcutaneous apomorphine infusion (CSAI) | University Hospital, Toulouse, ELIVIE France, EVER Pharma France SAS, NHC SAS, France, Orkyn', ETPARK Association, Toulouse, France | Parkinson Disease | 04/26 | 04/26 | | |
| SOMME, Dominique |
| Not yet recruiting | N/A | 30 | NA | Health monitors | Rennes University Hospital, AZNetwork, RF-Track, LTSI Rennes | Aging, Frailty | 09/23 | 03/24 | | |
| Recruiting | N/A | 100 | Europe | additional blood sample | Rennes University Hospital | Drug Resistance | 07/25 | 01/26 | | |
| Corvol, Aline |
| Recruiting | N/A | 108 | Europe | SECURIDRAP® SELFIA® | Groupe Mulliez-Flory, EVAMED | Disorientation, Cognitive Impairment, Behavior Disorders | 10/22 | 12/22 | | |
| Not yet recruiting | N/A | 200 | Europe | Hospi'Senior, Conventional room | University Hospital, Angers | Elderly Inpatients | 10/25 | 01/26 | | |
| BEURRIER, Philippe |
| Completed | 2 | 13 | Europe | Eltrombopag | University Hospital, Toulouse, French network for inherited hemorragic diseases, National Reference Centre for Platelet Pathologies | Thrombocytopenia | 06/23 | 06/23 | | |
TWIGO, NCT05773638: Cardiovascular and Venous Thromboembolism Disease in Patients with Von Willebrand Disease in the French West |
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| Recruiting | N/A | 100 | Europe | | University Hospital, Brest | Von Willebrand Diseases | 12/26 | 12/26 | | |
GIDEMHA, NCT05628558: Genetic Influence of Genetic Factors Influencing the Desmopressin's Efficacy in Mild/Moderate Hemophilia A |
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| Recruiting | N/A | 800 | Europe | Desmopressin, DDAVP | Groupe Maladies hémorragiques de Bretagne | Hemophilia A, Mild, Desmopressin, Factor VIII | 12/22 | 04/23 | | |
| PAN-PETESCH, Brigitte |
RENOVE, NCT03285438: REduced Dose Versus Full-dose of Direct Oral Anticoagulant After uNprOvoked Venous thromboEmbolism. |
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| Completed | 3 | 2774 | Europe | Reduced dose of DOAC, Full dose of DOAC | University Hospital, Brest, University Hospital of Saint-Etienne | Venous Thromboembolism | 11/23 | 11/23 | | |
NCT02932618 / 2016-001477-33: A Study of Recombinant Von Willebrand Factor (rVWF) With or Without ADVATE in Children With Severe Von Willebrand Disease (VWD) |
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| Recruiting | 3 | 34 | Europe, US, RoW | von Willebrand factor (Recombinant), VONVENDI, rVWF, BAX111, BAX 111, Antihemophilic Factor (Recombinant), ADVATE, Recombinant Factor VIII, rFVIII | Baxalta now part of Shire, Takeda Development Center Americas, Inc. | Von Willebrand Disease | 01/25 | 01/25 | | |
| Recruiting | N/A | 500 | Europe | | University Hospital, Brest | Immune Thrombocytopenia | 11/20 | 11/39 | | |
SENIORHEMO, NCT05218772: Objective and Perceived Health Status of Elderly People With Moderate or Severe Haemophilia in France: an Ancillary Study of the FranceCoag Registry |
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| Recruiting | N/A | 612 | Europe | Questionnaires | Assistance Publique Hopitaux De Marseille | Moderate or Serious Haemophilia | 06/23 | 12/23 | | |
| Recruiting | N/A | 480 | Europe | Bone densitometry (BMD), Blood sampling for patients only | Centre Hospitalier Universitaire de Saint Etienne, Ministry of Health, France | Hemophilia | 12/24 | 03/25 | | |
WILL MANAGE, NCT06651255: Algorithm-based Management to Reduce the Recurrence of Gastrointestinal Bleeding and Severe Epistaxis in Von Willebrand Disease |
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| Not yet recruiting | N/A | 66 | Europe | Optimized management, Standard of care management | University Hospital, Lille | Von Willebrand Disease (VWD) | 01/34 | 12/34 | | |
GIDEMHA, NCT05628558: Genetic Influence of Genetic Factors Influencing the Desmopressin's Efficacy in Mild/Moderate Hemophilia A |
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| Recruiting | N/A | 800 | Europe | Desmopressin, DDAVP | Groupe Maladies hémorragiques de Bretagne | Hemophilia A, Mild, Desmopressin, Factor VIII | 12/22 | 04/23 | | |
| ARDILLON, Laurent |
SENIORHEMO, NCT05218772: Objective and Perceived Health Status of Elderly People With Moderate or Severe Haemophilia in France: an Ancillary Study of the FranceCoag Registry |
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| Recruiting | N/A | 612 | Europe | Questionnaires | Assistance Publique Hopitaux De Marseille | Moderate or Serious Haemophilia | 06/23 | 12/23 | | |
| Active, not recruiting | N/A | 70 | Europe | Blood test | University Hospital, Clermont-Ferrand | Hereditary Dysfibrinogenemia | 05/24 | 12/24 | | |
WILL MANAGE, NCT06651255: Algorithm-based Management to Reduce the Recurrence of Gastrointestinal Bleeding and Severe Epistaxis in Von Willebrand Disease |
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| Not yet recruiting | N/A | 66 | Europe | Optimized management, Standard of care management | University Hospital, Lille | Von Willebrand Disease (VWD) | 01/34 | 12/34 | | |
| Active, not recruiting | N/A | 2093 | Europe, RoW | Hydroxycarbamide, Siklos, Hydroxyurea | Theravia, International Clinical Trials Association | Sickle Cell Disease | 08/25 | 08/25 | | |
GIDEMHA, NCT05628558: Genetic Influence of Genetic Factors Influencing the Desmopressin's Efficacy in Mild/Moderate Hemophilia A |
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| Recruiting | N/A | 800 | Europe | Desmopressin, DDAVP | Groupe Maladies hémorragiques de Bretagne | Hemophilia A, Mild, Desmopressin, Factor VIII | 12/22 | 04/23 | | |
| Biraben, Arnaud |
| Completed | 3 | 128 | Europe, Canada, US, RoW | Ganaxalone, Placebo | Marinus Pharmaceuticals, Marinus Pharmaceuticals Inc., Marinus Pharmaceuticals, Inc. | Tuberous Sclerosis Complex | 09/24 | 10/24 | | |
CENOR, NCT05747001: This is a Retrospective Study on the Use of CENOBAMATE as Adjunctive Treatment in Patients Suffering From Epilepsy in Early Access Program in Germany, France and UK |
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| Completed | N/A | 319 | Europe | | Aziende Chimiche Riunite Angelini Francesco S.p.A, Hippocrates Research | Focal Onset Seizure, Epilepsy | 09/23 | 09/23 | | |
| Recruiting | N/A | 140 | Europe | Choice of VNS set of parameters based on the lowest PLI, EEG | Assistance Publique Hopitaux De Marseille | Epilepsy | 06/25 | 12/26 | | |
| Lejeune, Florence |
| Recruiting | 3 | 88 | Europe | PET/CT with 18F-DOPA | Central Hospital, Nancy, France | Glioma | 12/25 | 10/26 | | |
| Active, not recruiting | 2 | 31 | Europe | [18F]DPA-714 PET scan | Nantes University Hospital | Parkinson Disease | 05/24 | 05/24 | | |
| NIMUBONA, Stanislas |
| Recruiting | 3 | 124 | Europe | EPREX, Epoetin alfa | Groupe Francophone des Myelodysplasies | Myelodysplastic Syndromes | 05/22 | 05/24 | | |
| Completed | 2 | 99 | Europe, RoW | Hydroxycarbamide, Siklos, Placebo Oral Tablet | Theravia | Sickle Cell Disease | 05/24 | 05/24 | | |
NCT04827719: BST-236 as a Single Agent in Adults With Relapsed or Refractory AML or HR-MDS |
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| Active, not recruiting | 2 | 40 | Europe | BST-236 | Groupe Francophone des Myelodysplasies | Myelodysplastic Syndromes, Acute Myeloid Leukemia | 04/25 | 04/25 | | |
AVENHIR, NCT05768711: Azacitidine Combined With Venetoclax in Patients With Higher-risk Chronic Myelomonocytic Leukemia |
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| Recruiting | 2 | 44 | Europe | Venetoclax, ABT-199 | Groupe Francophone des Myelodysplasies, AbbVie | Chronic Myeloid Leukemia | 02/26 | 10/28 | | |
NCT05181735: Study Evaluating Combination of Luspatercept in LR-MDS Without RS Having Failed or Being Ineligible to ESA |
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| Recruiting | 1/2 | 150 | Europe | Luspatercept Injection [Reblozyl], ACE-536, Eprex, Epoietin alfa | Groupe Francophone des Myelodysplasies, Celgene | MDS, Myelodysplastic Syndromes | 05/27 | 11/27 | | |
NCT03643042: Impact of 2 Transfusion Strategies on Quality of Life of Multitransfused Patients With Low-risk Myelodysplastic Syndrome |
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| Terminated | N/A | 11 | Europe | Transfusion | Lille Catholic University | Myelodysplastic Syndromes, Transfusion-dependent Anemia | 09/22 | 03/23 | | |
| Active, not recruiting | N/A | 2093 | Europe, RoW | Hydroxycarbamide, Siklos, Hydroxyurea | Theravia, International Clinical Trials Association | Sickle Cell Disease | 08/25 | 08/25 | | |
| Nesseler, Nicolas |
MYOCOVID, NCT04375748: Hospital Registry of Acute Myocarditis: Evolution of the Proportion of Positive SARS-COV-2 (COVID19) Cases |
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| Completed | N/A | 756 | Europe, RoW | Performing routine care (clinical and paraclinical tests), Examinations for the research: | University Hospital, Toulouse | Acute Myocarditis | 12/21 | 12/21 | | |
VIRUS-ATTAC, NCT04562207: Pre-operative Carriage of Respiratory VIRUSes, and Acute Respiratory Distress Syndrome After Heart Surgery |
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| Completed | N/A | 1256 | Europe | Screening for respiratory virus infection | Rennes University Hospital | Heart; Surgery, Heart, Functional Disturbance as Result | 02/23 | 03/23 | | |
NCT06596096: Risk Factors for Beta-lactam Target Non Attainment in Critically Ill Patients BETALACTACRIT |
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| Recruiting | N/A | 300 | Europe | | Centre Hospitalier de Saint-Brieuc | Sepsis | 06/25 | 07/25 | | |
VACARM, NCT04408495: Intraoperative Mechanical Ventilation and Postoperative Pulmonary Complications After On-pump Cardiac Surgery in High-risk Patients |
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| Recruiting | N/A | 440 | Europe | Intervention group_MRA, recruitment maneuvers, Control group, NO recruitment maneuvers | Rennes University Hospital | Postoperative Pulmonary Complications | 08/25 | 07/26 | | |
| Launey, Yoann |
| Recruiting | 3 | 360 | Europe | Milrinone 1 Mg/mL Solution for Injection, Corotrope, Saline solution for injection, Sodium Chloride 0.9% | University Hospital, Angers | Vasospasm | 08/23 | 02/24 | | |
HAP-DEX, NCT06269900: Dexamethasone for Treating Severe Hospital-acquired Pneumonia in Critically Ill Patients With a Proinflammatory Phenotype |
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| Recruiting | 3 | 450 | Europe | Dexamethasone, Placebo | Nantes University Hospital | Hospital Acquired Pneumonia | 03/26 | 08/26 | | |
TREAT-HAP, NCT05914584: "Baricitinib for Treating Hospital-acquired Pneumonia in Critically Ill Patients With a Proinflammatory Phenotype. |
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| Not yet recruiting | 3 | 450 | Europe | Baricitinib 4 MG | Nantes University Hospital | Hospital-acquired Pneumonia | 08/25 | 12/25 | | |
ESPER, NCT05891522: Pilot Study of the Use of a Portable Cranial Scanner in Intensive Care for Cerebro-injured Patients |
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| Completed | N/A | 46 | Europe | portable scanner, fixed scanner | Rennes University Hospital | Craniocerebral Trauma | 01/21 | 01/21 | | |
| Completed | N/A | 100 | Europe | | University Hospital, Clermont-Ferrand, Hôpital Edouard Herriot, Rangueil Hospital, Hospices Civils de Lyon, Hopital Louis Pradel, Hôpital Saint Camille, Hôpital de la Timone, University Hospital, Grenoble, University Hospital, Lille, Saint Antoine University Hospital, University Hospital, Strasbourg, University Hospital, Marseille, Centre Hospitalier Universitaire de Nīmes, CH Aix, CH Martigues, CH Alberville, CH Chambery, Rennes University Hospital, Bichat Hospital | Intensive Care Unit | 11/21 | 12/21 | | |
| Completed | N/A | 1066 | Europe, RoW | Quantification of IV drugs wastage | Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer, Sainte-Anne Military Teaching Hospital | Drug Use | 03/23 | 03/23 | | |
| Recruiting | N/A | 30 | Europe | Clinical data collection, Therapeutic data collection, IntraCranial Pression (ICP) values collection | Centre Hospitalier Universitaire de Saint Etienne | Cerebrospinal; Disorder | 04/24 | 04/24 | | |
NCT06596096: Risk Factors for Beta-lactam Target Non Attainment in Critically Ill Patients BETALACTACRIT |
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| Recruiting | N/A | 300 | Europe | | Centre Hospitalier de Saint-Brieuc | Sepsis | 06/25 | 07/25 | | |
ICITRU, NCT04513288: : Randomized Trial of Immunonutrition With L-citrulline in Patients Hospitalized in Intensive Care for Sepsis or Septic Shock |
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| Recruiting | N/A | 130 | Europe | Experimental treatment L-citrulline (Protéocit®), Placebo treatment | Rennes University Hospital | Sepsis, Septic Shock | 11/26 | 11/26 | | |
HOMI-LUNG-HAP, NCT06602934: Long-term Alterations of Host-microbiome Interactions and Cardiovascular and Respiratory Diseases Progression After Pneumonia |
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| Recruiting | N/A | 300 | Europe | Blood samples, Oropharyngeal swabs, Calcium score (CT scan), ECG, Cardiopulmonary exercise test, spirometry, plethysmography, pulmonary absorption of carbon monoxide in a single inspiration, and 6-minute walk test | Nantes University Hospital | Hospital Acquired Pneumonia (HAP), Cardiovascular and Respiratory Disease | 01/29 | 05/29 | | |
