| Fearon, William F |
| Recruiting | 3 | 445 | RoW | Tenecteplase (1/3 systemic weight based dose), TNKase, Sterile water for injection (WFI) | University of Sydney, Genentech, Inc. | STEMI, Elevated IMR (>32) | 12/24 | 12/26 | | |
NCT03537742: Cardiac Allograft Vasculopathy Inhibition with Alirocumab |
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| Active, not recruiting | 2 | 120 | US | alirocumab, Praluent, placebo | Stanford University, National Heart, Lung, and Blood Institute (NHLBI) | Vasculopathy | 07/25 | 08/25 | | |
FAME 3, NCT02100722: A Comparison of Fractional Flow Reserve-Guided Percutaneous Coronary Intervention and Coronary Artery Bypass Graft Surgery in Patients With Multivessel Coronary Artery Disease |
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| Active, not recruiting | N/A | 1500 | Europe, Canada, US, RoW | FFR guided PCI, Fractional Flow Reserve-Guided PCI, CABG, Resolute Integrity Stent, Resolute Onyx Stent | Stanford University, VZW Cardiovascular Research Center Aalst, Catharina Ziekenhuis Eindhoven, Golden Jubilee National Hospital, University of California, Irvine, Medtronic, Abbott Medical Devices, Genae, King's College Hospital, London, Houston Methodist DeBakey Heart and Vascular Center, Houston | Coronary Disease, Coronary Stenosis | 12/20 | 12/24 | | |
| Completed | N/A | 888 | Europe, US, RoW | | CoreAalst BV, Abbott Medical Devices | Coronary Artery Disease | 05/24 | 05/24 | | |
| Recruiting | N/A | 1247 | Europe, Canada, US | Edwards PASCAL System, Transcatheter Mitral Valve repair (TMVr), Abbott Mitraclip System | Edwards Lifesciences | Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation | 01/25 | 04/30 | | |
| Recruiting | N/A | 1924 | Europe, Japan, US, RoW | FFRangio, FFR or NHPR, FFR, iFR RFR, dPR, Pd/Pa | CathWorks Ltd., Cardiovascular Research Foundation, New York | Percutaneous Coronary Intervention | 12/24 | 12/24 | | |
| Recruiting | N/A | 150 | US | HF-OCT Imaging, FFR Pressure Wire, Angiography | Gentuity, LLC | Coronary Stenosis | 12/24 | 12/24 | | |
| Rassaf, Tienush |
| Recruiting | 4 | 72 | Europe | Heart failure medication, Placebo | University Hospital, Essen | Pre-terminal Cancer | 05/24 | 10/24 | | |
| Recruiting | 2/3 | 130 | Europe | Mycophenolate Mofetil, MMF, Prednisolone, Mycophenolate Mofetil Placebo, MMF Placebo, Prednisolone Placebo | LMU Klinikum, Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK), Technical University of Munich, Charite University, Berlin, Germany, University Hospital, Essen, University Hospital Erlangen, University Hospital Tuebingen | Inflammatory Cardiomyopathy | 03/27 | 03/28 | | |
| Recruiting | N/A | 40 | Europe | Dietary Nitrate, Control | University Hospital, Essen | Erectile Dysfunction | 06/21 | 08/21 | | |
NCT04183660: A Post Market Surveillance Study of the Hemovent Extracorporeal Cardiopulmonary Support System:The MOBYBOX Trial |
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| Recruiting | N/A | 60 | Europe | MOBYBOX System | Hemovent GmbH, seleon GmbH | Cardiac Failure, Respiratory Failure, Cardio-Respiratory Failure | 04/25 | 12/25 | | |
NCT05447052: The Biomimetic Stent and Vascular Functions Study |
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| Recruiting | N/A | 70 | Europe | Bio-MIMICS 3D Stent, Innova Stent | University Hospital, Essen | Peripheral Arterial Disease | 04/24 | 04/25 | | |
| Completed | N/A | 30 | Europe | Nitrate, Control | University Hospital, Essen | Cardiovascular Health | 06/24 | 06/24 | | |
| Recruiting | N/A | 1000 | Europe | Edwards PASCAL Transcatheter Valve Repair System and Edwards PASCAL Precision Transcatheter Valve Repair System | Edwards Lifesciences | Mitral Regurgitation, Mitral Insufficiency | 12/25 | 03/31 | | |
| Completed | N/A | 60 | Europe | Standard of care treatment | University Hospital, Essen | Microbial Colonization, Coronary Artery Disease, Myocardial Infarction, Acute Coronary Syndrome, Peripheral Arterial Disease, Critical Limb Ischemia | 02/24 | 04/24 | | |
| Recruiting | N/A | 55000 | Europe | | University Hospital, Essen | Coronary Artery Disease | 12/26 | 06/27 | | |
| Recruiting | N/A | 1247 | Europe, Canada, US | Edwards PASCAL System, Transcatheter Mitral Valve repair (TMVr), Abbott Mitraclip System | Edwards Lifesciences | Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation | 01/25 | 04/30 | | |
NCT05450042: Vascular Effects Through Sirolimus vs. Paclitaxel DCB Implantation |
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| Recruiting | N/A | 70 | Europe | SELUTION SLR DCB, Paclitaxel DCB | University Hospital, Essen | Peripheral Arterial Disease, Flow-mediated Dilation, Drug Eluting Balloon, Infrainguinal Peripheral Arterial Disease | 04/24 | 04/24 | | |
PROTECT IV, NCT04763200: Impella®-Supported PCI in High-Risk Patients With Complex Coronary Artery Disease and Reduced Left Ventricular Function |
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| Recruiting | N/A | 1252 | Europe, Canada, US | Impella CP® / Impella CP® with SmartAssist® / Impella 2.5®, IABP Intra-aortic balloon pump | Abiomed Inc. | Left Ventricular Dysfunction, Coronary Artery Disease | 03/26 | 10/27 | | |
| Recruiting | N/A | 360 | Europe | Transcatheter tricuspid valve treatment (TTVT) | LMU Klinikum, Heart and Diabetes Center North Rhine-Westphalia, University Medical Center Mainz, Heart Center Leipzig - University Hospital, Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK), University of Leipzig | Heart Failure Attributable to Severe Tricuspid Regurgitation | 03/26 | 03/27 | | |
| Recruiting | N/A | 1054 | Europe | measurement of FFR, measurement of Pd/Pa | Helios Health Institute GmbH, Heart Center Leipzig - University Hospital | Coronary Artery Disease, Coronary Artery Stenoses | 05/26 | 11/26 | | |
RIP-HIGH, NCT04844931: Remote Ischemic Conditioning With Local Ischemic Postconditioning in High-Risk ST-elevation Myocardial Infarction |
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| Active, not recruiting | N/A | 250 | Europe | RIC + PostC + Standard PCI, Standard PCI | Helios Health Institute GmbH, Heart Center Leipzig - University Hospital | ST Elevation Myocardial Infarction | 12/25 | 07/30 | | |
| Recruiting | N/A | 3390 | Europe | Culprit-lesion revascularization, Culprit-lesion PCI, Non-culprit-lesion revascularization, multivessel PCI | Leipzig Heart Science gGmbH, Heart Center Leipzig at University of Leipzig, German Federal Ministry of Education and Research, IHF GmbH - Institut für Herzinfarktforschung, Stiftung IHF - Institut für Herzinfarktforschung | Non-ST-elevation Myocardial Infarction, Multivessel Coronary Artery Disease | 01/27 | 07/27 | | |
| Weymann, Alexander |
| Recruiting | N/A | 1247 | Europe, Canada, US | Edwards PASCAL System, Transcatheter Mitral Valve repair (TMVr), Abbott Mitraclip System | Edwards Lifesciences | Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation | 01/25 | 04/30 | | |
| Recruiting | N/A | 800 | US | No interventions | Children's Hospital Medical Center, Cincinnati | Autoimmune Hepatitis, Primary Sclerosing Cholangitis | 12/32 | 06/33 | | |
| Lind, Alexander |
| Recruiting | N/A | 1247 | Europe, Canada, US | Edwards PASCAL System, Transcatheter Mitral Valve repair (TMVr), Abbott Mitraclip System | Edwards Lifesciences | Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation | 01/25 | 04/30 | | |
| Arabyan, Mane Arabyan |
| Active, not recruiting | N/A | 572 | Europe, Canada, US | TriClipTM Device | Abbott Medical Devices | Tricuspid Regurgitation | 11/22 | 04/29 | | |
| Recruiting | N/A | 250 | Europe, US | reSept ASD Occluder | atHeart Medical | Heart Septal Defect, Heart Septal Defects, Atrial, Heart Defects, Congenital, Cardiovascular Abnormalities, Cardiovascular Diseases, Heart Diseases, Congenital Abnormalities | 12/26 | 12/30 | | |
| Recruiting | N/A | 1247 | Europe, Canada, US | Edwards PASCAL System, Transcatheter Mitral Valve repair (TMVr), Abbott Mitraclip System | Edwards Lifesciences | Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation | 01/25 | 04/30 | | |
| Recruiting | N/A | 25 | US | CardioMech MVRS | CardioMech AS | Mitral Regurgitation | 12/25 | 12/30 | | |
SUMMIT, NCT03433274: Clinical Trial to Evaluate the Safety and Effectiveness of Using the Tendyne Transcatheter Mitral Valve System for the Treatment of Symptomatic Mitral Regurgitation |
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| Recruiting | N/A | 958 | Canada, US | Tendyne Mitral Valve System, MitraClip System | Abbott Medical Devices | Mitral Regurgitation, Mitral Insufficiency, Mitral Valve Insufficiency, Cardiovascular Diseases, Valve Disease, Heart, Heart Valve Diseases, Functional Mitral Regurgitation, Degenerative Mitral Valve Disease | 05/24 | 06/28 | | |
NCT05913908: EFS of the DUO System for Tricuspid Regurgitation |
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| Recruiting | N/A | 15 | US | DUO Transcatheter Tricuspid Coaptation Valve System, DUO System | CroiValve Limited | Tricuspid Regurgitation, Tricuspid Valve Insufficiency, Tricuspid Valve Disease, Heart Valve Diseases | 12/25 | 10/29 | | |
NCT06212193: Innoventric Trillium™ Stent Graft Early Feasibility Study (EFS) |
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| Recruiting | N/A | 15 | US | Trillium™ | Innoventric LTD, Innoventric Inc. | Tricuspid Regurgitation, Tricuspid Regurgitation Functional | 08/25 | 08/30 | | |
| Recruiting | N/A | 1857 | US | WATCHMAN FLX Pro LAAC Device, WATCHMAN FLX Pro Left Atrial Appendage Closure Device | Boston Scientific Corporation | Atrial Fibrillation, Stroke, Bleeding | 07/26 | 01/27 | | |
| Recruiting | N/A | 15 | US | AltaValve | 4C Medical Technologies, Inc. | Mitral Regurgitation, Mitral Insufficiency, Mitral Valve Incompetence, Mitral Valve Regurgitation, Mitral Incompetence | 09/25 | 09/25 | | |
VISTA-US, NCT05848284: Clinical Safety and Efficacy of the VDyne Transcatheter Tricuspid Valve Replacement System for the Treatment of Tricuspid Regurgitation ( ) |
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| Recruiting | N/A | 30 | US | VDyne Transcatheter Tricuspid Valve Replacement System, VDyne System, VDyne Tricuspid System, VDyne Valve System, VDyne Valve | VDyne, Inc. | Tricuspid Regurgitation, Tricuspid Valve Disease, Tricuspid Valvular Disorders | 11/25 | 11/30 | | |
| Recruiting | N/A | 500 | Europe, Canada, US | MitraClip™ device implantation, Mitral Valve Repair Surgery | Abbott Medical Devices | Mitral Valve Regurgitation | 04/26 | 04/34 | | |
| Liang, David |
| Recruiting | N/A | 1247 | Europe, Canada, US | Edwards PASCAL System, Transcatheter Mitral Valve repair (TMVr), Abbott Mitraclip System | Edwards Lifesciences | Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation | 01/25 | 04/30 | | |
| Ludike, Peter |
| Recruiting | N/A | 1247 | Europe, Canada, US | Edwards PASCAL System, Transcatheter Mitral Valve repair (TMVr), Abbott Mitraclip System | Edwards Lifesciences | Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation | 01/25 | 04/30 | | |
| Schmack, Bastian |
NCT06699446: The "Seamless" Patient:From Preoperative Preparation to Postoperative Rehabilitation |
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| Recruiting | N/A | 300 | Europe | pre rehabilitation | Hannover Medical School | Heart Failure | 06/26 | 12/26 | | |
| Recruiting | N/A | 1247 | Europe, Canada, US | Edwards PASCAL System, Transcatheter Mitral Valve repair (TMVr), Abbott Mitraclip System | Edwards Lifesciences | Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation | 01/25 | 04/30 | | |
| Recruiting | N/A | 123 | Europe, RoW | Device: Impella 5.5 with SmartAssist | Abiomed Inc. | Left Ventricular Dysfunction | 06/25 | 06/26 | | |
| Riebisch, Matthias |
| Recruiting | N/A | 1247 | Europe, Canada, US | Edwards PASCAL System, Transcatheter Mitral Valve repair (TMVr), Abbott Mitraclip System | Edwards Lifesciences | Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation | 01/25 | 04/30 | | |
| Hendricks, Stefanie |
| Recruiting | N/A | 1247 | Europe, Canada, US | Edwards PASCAL System, Transcatheter Mitral Valve repair (TMVr), Abbott Mitraclip System | Edwards Lifesciences | Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation | 01/25 | 04/30 | | |
| Michel, Lars |
| Recruiting | N/A | 1247 | Europe, Canada, US | Edwards PASCAL System, Transcatheter Mitral Valve repair (TMVr), Abbott Mitraclip System | Edwards Lifesciences | Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation | 01/25 | 04/30 | | |
| Mahabadi, Amir-Abbas |
| Recruiting | N/A | 1247 | Europe, Canada, US | Edwards PASCAL System, Transcatheter Mitral Valve repair (TMVr), Abbott Mitraclip System | Edwards Lifesciences | Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation | 01/25 | 04/30 | | |
| Weise, Alexander |
| Recruiting | N/A | 1247 | Europe, Canada, US | Edwards PASCAL System, Transcatheter Mitral Valve repair (TMVr), Abbott Mitraclip System | Edwards Lifesciences | Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation | 01/25 | 04/30 | | |
| Bukhari, Jessica |
| Active, not recruiting | 3 | 125 | Canada, US | Autologous cell therapy, Sham | BioCardia, Inc. | Heart Failure, Systolic | 12/24 | 12/26 | | |
| Recruiting | N/A | 1247 | Europe, Canada, US | Edwards PASCAL System, Transcatheter Mitral Valve repair (TMVr), Abbott Mitraclip System | Edwards Lifesciences | Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation | 01/25 | 04/30 | | |
NCT03970343: Post Approval Study (PAS) of the OPTIMIZER Smart and CCM Therapy |
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| Recruiting | N/A | 620 | US | OPTIMIZER Smart System | Impulse Dynamics | Heart Failure | 03/26 | 03/26 | | |
| Stumbaugh, Kyle |
| Recruiting | N/A | 1247 | Europe, Canada, US | Edwards PASCAL System, Transcatheter Mitral Valve repair (TMVr), Abbott Mitraclip System | Edwards Lifesciences | Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation | 01/25 | 04/30 | | |
| Recruiting | N/A | 216 | US | ACCEL® Absorbable Hemostat Powder, Gelfoam® (Absorbable Gelatin Sponge, Pfizer Manufacturer Part Number 0342-01), SURGIFOAM® (Absorbable Gelatin Sponge, Manufacturer Part Number ETH1974). | Hemostasis, LLC | Hemostasis | 11/24 | 01/25 | | |
| Phyu, Pan |
| Active, not recruiting | N/A | 149 | Europe, US | PerQseal® Closure Device System | Vivasure Medical Limited | Percutaneous Large Hole Vascular Closure | 12/24 | 06/25 | | |
| Recruiting | N/A | 1247 | Europe, Canada, US | Edwards PASCAL System, Transcatheter Mitral Valve repair (TMVr), Abbott Mitraclip System | Edwards Lifesciences | Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation | 01/25 | 04/30 | | |
