The University of North Carolina
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 17 Trials 
41 Trials

   

 
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Smith, Angela
NCT05555589: Assessment of the Safety and Efficacy of 0.1% RGN-259 Ophthalmic Solution for the Treatment of NK: SEER-2

Recruiting
3
70
US
RGN-259, TĪ²4, Thymosin Beta 4, Timbetasin, Placebo, Vehicle Control
ReGenTree, LLC
Neurotrophic Keratopathy
07/24
11/24
AUGMENT-101, NCT04065399 / 2020-004104-34: A Study of Revumenib in R/R Leukemias Including Those With an MLL/KMT2A Gene Rearrangement or NPM1 Mutation

Jan 2024 - Dec 2024: Market entry for acute leukemias
Hourglass Feb 2024 - Mar 2024 : Q1'24 - PDUFA date from FDA for R/R KMT2Ar acute leukemia
Dec 2022 - Dec 2023: Submission in US for relapsed/refractory acute leukemia
Jul 2023 - Sep 2023: Data from AUGMENT-101 trial for r/r AML
Checkmark Updated data from P1 portion of P1/2 AUGMENT-101 trial for AML
More
Recruiting
1/2
413
Europe, Canada, US, RoW
revumenib, SNDX-5613, cobicistat
Syndax Pharmaceuticals, Syndax Pharmaceuticals, Inc
Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Mixed Lineage Acute Leukemia, Mixed Phenotype Acute Leukemia, Acute Leukemia of Ambiguous Lineage
12/27
12/27
FORTIS, NCT04174105: Gene Transfer Study in Patients With Late Onset Pompe Disease

Recruiting
1/2
18
Europe, US
zocaglusagene nuzaparvovec, AT845
Astellas Gene Therapies
Pompe Disease (Late-onset)
11/29
11/29
NCT04565431: Examining Effects of Tysabri on Cognitive Fatigue Using fMRI

Recruiting
N/A
25
US
Tysabri
Kessler Foundation, St. Barnabas Medical Center
Multiple Sclerosis, Relapsing-Remitting
12/24
12/24
NCT04448977: Examining Effects of Ocrevus on Cognitive Fatigue Using fMRI

Recruiting
N/A
60
US
Ocrevus
Kessler Foundation, Hackensack Meridian Health
Multiple Sclerosis, Relapsing-Remitting
12/24
12/24
NCT05399004: Evaluating Sexual Function in Women Undergoing a Radical Cystectomy for Bladder Cancer

Completed
N/A
34
NA
Survey Administration
Mayo Clinic, National Cancer Institute (NCI)
Bladder Carcinoma
06/24
06/24
NCT05045794: Bridge to HOPE: Hypothermic Oxygenated Perfusion Versus Cold Storage Prior to Liver Transplantation

Completed
N/A
219
US
VitaSmart Liver Machine Perfusion System, VitaSmart Liver Machine, Hypothermic oxygenated perfusion, Static cold storage
Bridge to Life Ltd.
End Stage Liver DIsease, Liver Failure
06/24
06/24
CISTO, NCT03933826: Comparison of Intravesical Therapy and Surgery as Treatment Options for Bladder Cancer

Active, not recruiting
N/A
572
US
University of Washington, Patient-Centered Outcomes Research Institute
Bladder Cancer, Cancer of the Bladder, Recurrent, Non-muscle Invasive Bladder Cancer
12/24
03/25
KOAR, NCT03326076: Evaluation of Patient Outcomes From the Kidney Allograft Outcomes AlloSure Registry

Active, not recruiting
N/A
4000
US
Donor-derived cell-free DNA (AlloSureĀ®), Standard care, Peripheral blood gene expression profiling (AlloMap Kidney), Analytic platform (IBox)
CareDx
Kidney Transplant Rejection
06/25
12/25
Kuzmiak, Cherie M
TMIST, NCT03233191: Digital Tomosynthesis Mammography and Digital Mammography in Screening Patients for Breast Cancer

Active, not recruiting
3
108508
Europe, Canada, US, RoW
Digital Mammography, Full Field Digital Mammography, FFDM, Digital Tomosynthesis Mammography, DBT, Digital Breast Tomosynthesis, Digital Tomosynthesis of the Breast, Laboratory Biomarker Analysis, Biomarker analysis, genetic analysis, PAM50
ECOG-ACRIN Cancer Research Group, National Cancer Institute (NCI), Canadian Cancer Trials Group (CCTG)
Breast Screening
12/28
12/30
NCT05754749: Comparison of CE-DBT and MRI in Patients With Known Breast Lesions

Recruiting
1
20
US
Iohexol 350 Mg/mL Injectable Solution, Contrast- enhanced digital breast tomosynthesis (CE-DBT)
UNC Lineberger Comprehensive Cancer Center
Breast Cancer
08/25
08/25
Rao, Koneti
NCT05438407 / 2022-001624-14: Pediatric Patients Aged 4 to 11 Years with APDS

Active, not recruiting
3
15
Europe, Japan, US
Leniolisib
Pharming Technologies B.V., CMIC Co, Ltd. Japan, Labcorp Central Laboratory, Fortrea, Aixial Group
APDS
07/25
12/25
NCT05693129: Pediatric Patients Aged 1 to 6 Years with APDS

Recruiting
3
15
Europe, Japan, US
Leniolisib
Pharming Technologies B.V., CMIC Co, Ltd. Japan, Labcorp Central Laboratory, Fortrea, Aixial Group
APDS
09/25
02/26
Herfarth, Hans H
NCT04763564: Efficacy of Liraglutide Therapy in Patients With IPAA

Terminated
2
8
US
Liraglutide Pen Injector, Victoza, Placebo Pen Injector, Saline
University of North Carolina, Chapel Hill, Novo Nordisk A/S
Pouchitis, Irritable Pouch Syndrome
10/23
10/23
PROF, NCT05938465: Study of EXE-346 Live Biotherapeutic to Reduce High Bowel Movement Frequency in Subjects with an IPAA

Recruiting
1/2
50
US
EXE-346, Placebo
Exegi Pharma, LLC, The Emmes Company, LLC
Ileal Pouch
05/26
06/26
TOUR, NCT03772145: Tofacitinib Response in Ulcerative Colitis - a Real World Prospective Multi-center Study

Terminated
N/A
103
US
University of North Carolina, Chapel Hill, Pfizer
Ulcerative Colitis
01/23
01/24
NCT06696014: Mirikizumab Real World Protocol

Not yet recruiting
N/A
100
US
University of North Carolina, Chapel Hill, Eli Lilly and Company
Ulcerative Colitis
01/30
01/30
NCT04940611: A Study of Surgical Interventions in Fistulizing Conditions

Active, not recruiting
N/A
750
Europe, Canada, US, RoW
Takeda
Crohns Disease, Fistula, Rectovaginal Fistula, Complex Perianal Fistula, Complex Cryptoglandular Fistula
05/26
05/26
Lee, Yueh
NCT05480995: Evaluation of Endometriosis With 18F-fluorofuranylnorprogesterone PET / MRI

Recruiting
2
24
US
18F-fluorofuranylnorprogesterone PET / MRI
University of North Carolina, Chapel Hill, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Endometriosis
12/24
12/24
NCT05483023: 18-fluorofuranylnorprogesterone (FFNP) PET/MRI as a Potential Biomarker of Response to Progesterone Therapy

Recruiting
2
8
US
18F-fluorofuranylnorprogesterone PET / MRI
UNC Lineberger Comprehensive Cancer Center, Radiological Society of North America
Complex Atypical Hyperplasia, Endometrial Cancer
06/25
12/26
NCT04136912: 3-D Super Resolution Ultrasound Microvascular Imaging

Active, not recruiting
2
27
US
Definity, perflutren, Acoustic Angiography
UNC Lineberger Comprehensive Cancer Center, National Cancer Institute (NCI)
Breast Cancer, Thyroid Cancer
02/26
02/26
NCT05754749: Comparison of CE-DBT and MRI in Patients With Known Breast Lesions

Recruiting
1
20
US
Iohexol 350 Mg/mL Injectable Solution, Contrast- enhanced digital breast tomosynthesis (CE-DBT)
UNC Lineberger Comprehensive Cancer Center
Breast Cancer
08/25
08/25
NCT04495634: Evaluation of a Carbon Nanotube Enabled Solid-State Head CT

Completed
N/A
17
US
Stationary Head CT (s-HCT)
University of North Carolina, Chapel Hill, United States Department of Defense
Head Trauma
09/23
09/23
NCT03115333: DSC-MRI in Measuring rCBV for Early Response to Bevacizumab in Patients With Recurrent Glioblastoma

Recruiting
N/A
146
US
Dynamic Susceptibility Contrast-Enhanced Magnetic Resonance Imaging, DSC-MRI, Dynamic Susceptibility Contrast-Enhanced MRI, DYNAMIC SUSCEPTIBILITY-CONTRAST MRI
ECOG-ACRIN Cancer Research Group, National Cancer Institute (NCI)
Gliosarcoma, Recurrent Glioblastoma
05/25
05/27
Meldrum, Catherine
ALTITUDE, NCT04171492: Nodify XL2 Classifier Clinical Utility Study in Low to Moderate Risk Lung Nodules

Recruiting
N/A
2000
Canada, US
Biodesix, Inc.
Nodule Solitary Pulmonary, Non-small Cell Carcinoma
12/24
12/26
Jackson, Susan
TARGET-IBD, NCT03251118: A 5-year Longitudinal Observational Study of Patients Undergoing Therapy for Inflammatory Bowel Disease

Recruiting
N/A
15000
US
Target PharmaSolutions, Inc.
Inflammatory Bowel Diseases, Crohn's Disease, Ulcerative Colitis, Indeterminate Colitis
10/25
10/25
MAAIS, NCT01169194: Multi-Center African-American Inflammatory Bowel Disease Study

Recruiting
N/A
2400
US
Johns Hopkins University, National Institutes of Health (NIH), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Inflammatory Bowel Disease
08/27
08/27
Pettee, Jackson
MAC2v3, NCT03672630: Comparison of Two- Versus Three-antibiotic Therapy for Pulmonary Mycobacterium Avium Complex Disease

Active, not recruiting
2/3
474
Canada, US
Azithromycin, Zithromax, Ethambutol, Myambutol, Rifampin, Rifadin
Kevin Winthrop, Patient-Centered Outcomes Research Institute, National Jewish Health, The University of Texas Health Science Center at Tyler, University Health Network, Toronto, New York University, Medical University of South Carolina, Mayo Clinic, Louisiana State University Health Sciences Center in New Orleans, University of California, San Diego, Stanford University, University of Kansas, Vancouver Clinic, University of California, San Francisco, University of Washington, Johns Hopkins University, University of Miami, Emory University, University of Iowa, University of North Carolina, Temple University, Loma Linda University, Columbia University, University of Wisconsin, Madison, Northwell Health, Kaiser Permanente Hawaii, James A. Haley Veterans Administration Hospital
Mycobacterium Avium Complex, Nontuberculous Mycobacterium Infection
10/25
10/25
PTK0796-NTM-20203, NCT04922554: Oral Omadacycline Vs. Placebo in Adults with NTM Pulmonary Disease Caused by Mycobacterium Abscessus Complex (MABc)

Completed
2
66
US
Omadacycline Oral Tablet, Nuzyra, Placebo, placebo tablets
Paratek Pharmaceuticals Inc
Mycobacterium Infections, Nontuberculous, Mycobacterium Abscessus Infection, Nontuberculous Mycobacterial Lung Disease, Nontuberculous Mycobacterial Pulmonary Infection
06/24
07/24
ALTITUDE, NCT04171492: Nodify XL2 Classifier Clinical Utility Study in Low to Moderate Risk Lung Nodules

Recruiting
N/A
2000
Canada, US
Biodesix, Inc.
Nodule Solitary Pulmonary, Non-small Cell Carcinoma
12/24
12/26
Sellers, Subhashini
NCT05740618: Inhaled Mannitol on Mucociliary Clearance in Moderate to Severe Cystic Fibrosis

Recruiting
4
25
US
Mannitol Inhalant Product, Bronchitol; dry powder mannitol
University of North Carolina, Chapel Hill, Chiesi USA, Inc.
Cystic Fibrosis
03/25
03/25
NECTAR, NCT04924660: Novel Experimental COVID-19 Therapies Affecting Host Response

Completed
2/3
871
US
TXA127, TRV027, Placebo, Fostamatinib
Sean Collins, National Institutes of Health (NIH), National Heart, Lung, and Blood Institute (NHLBI)
COVID-19, SARS-CoV-2 Infection, Coronavirus Infection
10/23
12/23
DEPTH, NCT05382208: Doxycycline for Emphysema in People Living With HIV (The Trial)

Recruiting
2
250
US
Doxycycline, Placebo
Weill Medical College of Cornell University, National Heart, Lung, and Blood Institute (NHLBI), University of California, Los Angeles, University of Iowa, University of Michigan
Emphysema, HIV
02/27
02/27
Raju, Sarath
DEPTH, NCT05382208: Doxycycline for Emphysema in People Living With HIV (The Trial)

Recruiting
2
250
US
Doxycycline, Placebo
Weill Medical College of Cornell University, National Heart, Lung, and Blood Institute (NHLBI), University of California, Los Angeles, University of Iowa, University of Michigan
Emphysema, HIV
02/27
02/27
Konenti, Rao
NCT05438407 / 2022-001624-14: Pediatric Patients Aged 4 to 11 Years with APDS

Active, not recruiting
3
15
Europe, Japan, US
Leniolisib
Pharming Technologies B.V., CMIC Co, Ltd. Japan, Labcorp Central Laboratory, Fortrea, Aixial Group
APDS
07/25
12/25
NCT05693129: Pediatric Patients Aged 1 to 6 Years with APDS

Recruiting
3
15
Europe, Japan, US
Leniolisib
Pharming Technologies B.V., CMIC Co, Ltd. Japan, Labcorp Central Laboratory, Fortrea, Aixial Group
APDS
09/25
02/26
Burks, Cole
ALTITUDE, NCT04171492: Nodify XL2 Classifier Clinical Utility Study in Low to Moderate Risk Lung Nodules

Recruiting
N/A
2000
Canada, US
Biodesix, Inc.
Nodule Solitary Pulmonary, Non-small Cell Carcinoma
12/24
12/26
Wu, Eve
NCT05693129: Pediatric Patients Aged 1 to 6 Years with APDS

Recruiting
3
15
Europe, Japan, US
Leniolisib
Pharming Technologies B.V., CMIC Co, Ltd. Japan, Labcorp Central Laboratory, Fortrea, Aixial Group
APDS
09/25
02/26
Thorson, Willa
NCT05795361: Post-trial Access Program of Idursulfase-IT Along With Elaprase in Children With Hunter Syndrome

Available
N/A
Europe, US, RoW
Idursulfase-IT, HGT-2310, TAK-609
Takeda
Hunter Syndrome
 
 
Staitieth, Bashar
DEPTH, NCT05382208: Doxycycline for Emphysema in People Living With HIV (The Trial)

Recruiting
2
250
US
Doxycycline, Placebo
Weill Medical College of Cornell University, National Heart, Lung, and Blood Institute (NHLBI), University of California, Los Angeles, University of Iowa, University of Michigan
Emphysema, HIV
02/27
02/27
Hazelet, Meaghan
BREASTChoice, NCT06817226: BREAST Choice Decision Tool R21

Recruiting
N/A
40
US
Assess decision making context., Solicit input from the target population, Integration and refinemen of the decision aid
UNC Lineberger Comprehensive Cancer Center, National Cancer Institute (NCI)
Breast Cancer
08/25
08/25

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