| Natale, Andrea |
FADE-DRT, NCT04502017: Efficacy of Different Anti-Thrombotic Strategies on Device-Related Thrombosis Prevention After Percutaneous Left Atrial Appendage Occlusion |
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| Recruiting | 4 | 360 | US | ASA plus Clopidogrel, Genetic-Tailored AntiThrombotic Strategy, Half-Dose of novel OAC | Texas Cardiac Arrhythmia Research Foundation | Device-Related Thrombosis, Atrial Fibrillation, Left Atrial Appendage Occlusion | 12/22 | 12/23 | | |
| Recruiting | 4 | 360 | Europe, US | Catheter ablation, Ablation, Rate or Rhythm control antiarrhythmic drugs for atrial fibrillation, Antiarrhythmic Drug, Insertion of CardioMems Hemodynamic monitor, IPM, Empiric heart failure drug therapy, HFDrug | Electrophysiology Research Foundation | Atrial Fibrillation, Heart Failure, Diastolic Heart Failure | 12/24 | 06/25 | | |
CHANGE AFIB, NCT05130268: Early Dronedarone Versus Usual Care to Improve Outcomes in Persons With Newly Diagnosed Atrial Fibrillation |
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| Completed | 4 | 339 | US | Dronedarone, Multaq | American Heart Association, Duke Clinical Research Institute, Sanofi | Atrial Fibrillation | 01/24 | 06/24 | | |
RAAFT-3, NCT04037397: First Line Radiofrequency Ablation Versus Antiarrhythmic Drugs for Persistent Atrial Fibrillation Treatment |
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| Completed | 3 | 25 | US | Anti Arrhythmics, Pulmonary Vein Isolation performed by Radio Frequency Catheter Ablation | University of Pennsylvania, Biosense Webster, Inc., Texas Cardiac Arrhythmia Research Foundation | Atrial Fibrillation | 10/24 | 10/24 | | |
| Recruiting | N/A | 888 | US | | Texas Cardiac Arrhythmia Research Foundation | Atrial Fibrillation, Mild Cognitive Impairment, Dementia | 06/20 | 12/22 | | |
| Recruiting | N/A | 50 | US | radiofrequency catheter ablation, RFCA | Texas Cardiac Arrhythmia Research Foundation | Atrial Fibrillation, Obesity | 08/20 | 12/22 | | |
TREASURE, NCT03503253: Transcatheter Leak Closure With Detachable Coils Following Incomplete Left Atrial Appendage Closure Procedures |
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| Recruiting | N/A | 120 | US | Interlock-35 Fibered IDC Occlusion System, Concerto Helix Detachable Coil System, Azur Peripheral Coil System | Texas Cardiac Arrhythmia Research Foundation | Left Atrial Appendage Incomplete Closure | 05/21 | 05/22 | | |
GenCov, NCT04506229: Genetic Mechanisms Underlying SARS-CoV-2 Infection and the Impact of COVID-19 on Cognitive Function |
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| Recruiting | N/A | 60 | US | Whole exome sequencing, Cognitive function | Texas Cardiac Arrhythmia Research Foundation | Covid19 | 08/21 | 09/21 | | |
| Recruiting | N/A | 200 | Europe, US | ILR, PMK, ICD | Texas Cardiac Arrhythmia Research Foundation | COVID-19, Atrial Fibrillation New Onset | 12/21 | 12/23 | | |
PLEA, NCT04216667: Posterior Wall And Left Atrial Appendage Empiric Electrical Isolation for Non-Paroxysmal Atrial Fibrillation |
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| Terminated | N/A | 124 | Europe, US, RoW | Catheter ablation | Montefiore Medical Center, Biosense Webster, Inc. | Atrial Fibrillation | 06/23 | 06/23 | | |
| Completed | N/A | 153 | Canada, US | Transseptal Aortic Approach Catheter Ablation Procedure, Retrograde Aortic Approach Catheter Ablation Procedure | University of California, San Francisco | Neurocognitive Dysfunction | 11/23 | 11/23 | | |
AVANT GUARD, NCT06096337: Pulsed Field Ablation (PFA) Vs Anti-Arrhythmic Drug (AAD) Therapy As a First Line Treatment for Persistent Atrial Fibrillation |
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| Recruiting | N/A | 520 | Europe, Canada, US, RoW | FARAPULSE™ Pulsed Field Ablation (PFA) System, Anti-Arrhythmic Drug (AAD): Flecainide, Sotalol, Propafenone, Dofetilide, and Dronedarone | Boston Scientific Corporation | Persistent Atrial Fibrillation | 12/25 | 12/27 | | |
| Recruiting | N/A | 206 | Canada, US | cryoablation procedure | Adagio Medical | Sustained VT | 12/25 | 03/26 | | |
COFFEE-AF, NCT05464940: Impact of Intravenous Caffeine on Atrial Electrical Properties and Potential Arrythmia Induction |
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| Not yet recruiting | N/A | 100 | US | Intravenous caffeine, Masked Placebo | Kansas City Heart Rhythm Research Foundation, Kansas City Heart Rhythm Institute, Overland Park, KS, Texas Cardiac Arrhythmia Institute, Austin, TX, USA, Loma Linda University, Loma Linda, California, USA | Atrial Fibrillation | 06/25 | 09/25 | | |
| Active, not recruiting | N/A | 152 | Europe, US | ensoETM. Esophageal cooling during AF ablation, Esophageal temperature monitoring probe | Advanced Cooling Therapy, Inc., d/b/a Attune Medical, University of Pennsylvania, Berry Consultants, Texas Cardiac Arrhythmia Research Foundation, Beth Israel Deaconess Medical Center, Kansas City Cardiac Arrhythmia Research LLC | AF - Atrial Fibrillation, Complication, Atrio-Esophageal Fistula | 05/26 | 05/26 | | |
| Active, not recruiting | N/A | 435 | Europe, Canada, US, RoW | Pulsed Field Ablation | Abbott Medical Devices | Atrial Arrhythmia, Atrial Fibrillation, Paroxysmal Atrial Fibrillation, Persistent Atrial Fibrillation | 01/26 | 01/26 | | |
DISRUPT-AF, NCT06335082: A Registry Based Collaborative to Measure Efficiency, Effectiveness, and Safety of Farapulse PFA Technology for AF |
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| Enrolling by invitation | N/A | 2000 | US | Pulsed Field Ablation | Heart Rhythm Clinical and Research Solutions, LLC, Boston Scientific Corporation | Atrial Fibrillation | 11/26 | 01/27 | | |
| Active, not recruiting | N/A | 153 | US | Standard Cryoballoon Pulmonary Vein Isolation (PVI), Arctic Front Advance Cardiac Cryoablation System, Cryoballoon PVI + Posterior Wall Isolation | Dignity Health Medical Foundation, Mercy General Hospital and Dignity Health Medical Foundation, Beth Israel Deaconess Medical Center, UC Health Medical Center, MedStar Georgetown University Hospital and Medical Center, Tampa Cardiac Specialists, Bethesda North Hospital, Brigham and Women's Hospital, Texas Cardiac Arrhythmia Institute At St. Davids Medical Center, St. Luke's Hospital and Health Network, Pennsylvania, Sarasota Memorial Health Care System, Nebraska Methodist Hospital-Methodist Physicians Clinic | Persistent Atrial Fibrillation | 04/24 | 12/24 | | |
ULTRA-HFIB, NCT04182620: Ultrasound-Based Renal Sympathetic Denervation as Adjunctive Upstream Therapy During Atrial Fibrillation Ablation |
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| Active, not recruiting | N/A | 160 | US | renal denervation, Catheter ablation | Vivek Reddy | Atrial Fibrillation | 03/25 | 03/25 | | |
PLATINUM, NCT05510167: Post-ablation Alcohol Impacts Arrhythmia Recurrence, Quality of Life and Cognition in AF |
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| Not yet recruiting | N/A | 130 | NA | Study arm | Texas Cardiac Arrhythmia Research Foundation | Atrial Fibrillation | 08/24 | 08/25 | | |
SAFFICIENT, NCT06488820: Safety and Efficacy of Pulsed-field Ablation for Atrial Fibrillation in High Versus Low-volume Ablation Centers |
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| Recruiting | N/A | 2276 | US | Catheter ablation using pulsed-field ablation (PFA) system | Texas Cardiac Arrhythmia Research Foundation | Atrial Fibrillation | 08/26 | 08/27 | | |
| Active, not recruiting | N/A | 949 | US | WATCHMAN FLX Pro LAAC Device, Left Atrial Appendage Closure | Boston Scientific Corporation | Atrial Fibrillation, Bleeding, Stroke | 07/24 | 08/25 | | |
| Recruiting | N/A | 1857 | US | WATCHMAN FLX Pro LAAC Device, WATCHMAN FLX Pro Left Atrial Appendage Closure Device | Boston Scientific Corporation | Atrial Fibrillation, Stroke, Bleeding | 07/26 | 01/27 | | |
| Enrolling by invitation | N/A | 583 | US | | Boston Scientific Corporation | Paroxysmal Atrial Fibrillation | 07/25 | 10/25 | | |
EFACT, NCT06699056: AI-Enabled Direct-from-ECG Ejection Fraction (EF) Severity Assessment Using COR ECG Wearable Monitor |
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| Recruiting | N/A | 1500 | US | 15-minutes of sitting during COR ECG Acquistion | Peerbridge Health, Inc | Ventricular Ejection Fraction, LVF, LV Dysfunction, Atrial Enlargement, Conduction Defect, Heart Failure, Valvular Heart Disease, Ischemic Heart Disease, Cardiotoxicity, Myocardial Infarction, Dilated Cardiomyopathy, HFrEF - Heart Failure with Reduced Ejection Fraction, HFpEF - Heart Failure with Preserved Ejection Fraction, Syncope, Remodeling, Cardiac | 09/25 | 09/25 | | |
NCT06676072: A Study of the TactiFlex SE Catheter and Volt PFA Generator in Subjects with PAF: |
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| Recruiting | N/A | 188 | Europe, US | PFA Ablation catheter | Abbott Medical Devices | Atrial Fibrillation (AF), Atrial Arrhythmia, Paroxysmal AF, Drug Refractory Paroxysmal Atrial Fibrillation | 04/26 | 04/26 | | |
NCT05988411: ULTRA-HFIB-Redo: Ultrasound-based Renal Sympathetic Denervation Vs Control in Redo Ablation Patients |
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| Recruiting | N/A | 250 | US | Renal Denervation, Catheter Ablation | Vivek Reddy | Paroxysmal Atrial Fibrillation, Persistent Atrial Fibrillation | 12/27 | 12/27 | | |
NCT03643224: DiamondTemp™ System for the Treatment of Persistent Atrial Fibrillation |
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| Completed | N/A | 376 | Europe, Canada, US, RoW | Radiofrequency Ablation | Medtronic Cardiac Rhythm and Heart Failure | Persistent Atrial Fibrillation, Atrial Fibrillation | 10/24 | 10/24 | | |
ADVANTAGE AF, NCT05443594: A Prospective Single Arm Open Label Study of the FARAPULSE Pulsed Field Ablation System in Subjects with Persistent Atrial Fibrillation |
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| Active, not recruiting | N/A | 669 | Europe, Canada, US | Phase 1: FARAPULSE Ablation System, Phase 2: FARAPULSE Ablation System | Boston Scientific Corporation | Persistent Atrial Fibrillation | 03/25 | 03/25 | | |
| Recruiting | N/A | 142 | Europe, US | AtriCure ISOLATOR Synergy Surgical Ablation System | AtriCure, Inc. | Inappropriate Sinus Tachycardia | 06/26 | 06/27 | | |
IVTCC, NCT04520347: 2.0: a Prospective Multicenter Ventricular Tachycardia Catheter Ablation Registry |
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| Enrolling by invitation | N/A | 10000 | Europe, Canada, Japan, US, RoW | | University of California, Los Angeles | Ventricular Arrhythmia, Ventricular Tachycardia, Premature Ventricular Contraction (PVC), Cardiomyopathy | 12/26 | 11/27 | | |
| Recruiting | N/A | 500 | Europe, US | AtriCure Commercially Available Devices | AtriCure, Inc. | Inappropriate Sinus Tachycardia, Postural Tachycardia Syndrome | 01/27 | 01/27 | | |
| Recruiting | N/A | 4000 | Europe, Canada, US | WATCHMAN device | Hamilton Health Sciences Corporation, McMaster University, Population Health Research Institute, Boston Scientific Corporation | Atrial Fibrillation, Stroke, Ischemic, Systemic Embolism | 09/29 | 12/29 | | |
| Recruiting | N/A | 500 | US | Rapid antibody test | Texas Cardiac Arrhythmia Research Foundation | IgM and IgG in Blood | 03/22 | 03/22 | | |
| Not yet recruiting | N/A | 382 | US | Imaging | Kansas City Heart Rhythm Research Foundation, Kansas City Heart Rhythm Institute, Texas Cardiac Arrhythmia Research Foundation, Montefiore Medical Center, Loma Linda University International Heart Institute | Myocarditis, Ischemia, Chest Pain | 03/25 | 05/25 | | |
| Sanchez, Javier |
NCT04088071: Real-world Experience of Catheter Ablation for the Treatment of Paroxysmal and Persistent Atrial Fibrillation |
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| Recruiting | N/A | 15000 | US | Catheter ablation | Heart Rhythm Clinical and Research Solutions, LLC, Biosense Webster, Inc. | Paroxysmal Atrial Fibrillation, Persistent Atrial Fibrillation | 12/27 | 12/27 | | |
| Mansour, Moussa |
AVANT GUARD, NCT06096337: Pulsed Field Ablation (PFA) Vs Anti-Arrhythmic Drug (AAD) Therapy As a First Line Treatment for Persistent Atrial Fibrillation |
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| Recruiting | N/A | 520 | Europe, Canada, US, RoW | FARAPULSE™ Pulsed Field Ablation (PFA) System, Anti-Arrhythmic Drug (AAD): Flecainide, Sotalol, Propafenone, Dofetilide, and Dronedarone | Boston Scientific Corporation | Persistent Atrial Fibrillation | 12/25 | 12/27 | | |
| Active, not recruiting | N/A | 200 | Europe, Canada, US | Adagio AF Cryoablation System (iCLAS™) | Adagio Medical | Persistent Atrial Fibrillation | 08/23 | 08/24 | | |
| Active, not recruiting | N/A | 435 | Europe, Canada, US, RoW | Pulsed Field Ablation | Abbott Medical Devices | Atrial Arrhythmia, Atrial Fibrillation, Paroxysmal Atrial Fibrillation, Persistent Atrial Fibrillation | 01/26 | 01/26 | | |
ULTRA-HFIB, NCT04182620: Ultrasound-Based Renal Sympathetic Denervation as Adjunctive Upstream Therapy During Atrial Fibrillation Ablation |
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| Active, not recruiting | N/A | 160 | US | renal denervation, Catheter ablation | Vivek Reddy | Atrial Fibrillation | 03/25 | 03/25 | | |
| Active, not recruiting | N/A | 949 | US | WATCHMAN FLX Pro LAAC Device, Left Atrial Appendage Closure | Boston Scientific Corporation | Atrial Fibrillation, Bleeding, Stroke | 07/24 | 08/25 | | |
| Enrolling by invitation | N/A | 583 | US | | Boston Scientific Corporation | Paroxysmal Atrial Fibrillation | 07/25 | 10/25 | | |
NCT03643224: DiamondTemp™ System for the Treatment of Persistent Atrial Fibrillation |
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| Completed | N/A | 376 | Europe, Canada, US, RoW | Radiofrequency Ablation | Medtronic Cardiac Rhythm and Heart Failure | Persistent Atrial Fibrillation, Atrial Fibrillation | 10/24 | 10/24 | | |
ADVANTAGE AF, NCT05443594: A Prospective Single Arm Open Label Study of the FARAPULSE Pulsed Field Ablation System in Subjects with Persistent Atrial Fibrillation |
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| Active, not recruiting | N/A | 669 | Europe, Canada, US | Phase 1: FARAPULSE Ablation System, Phase 2: FARAPULSE Ablation System | Boston Scientific Corporation | Persistent Atrial Fibrillation | 03/25 | 03/25 | | |
| Kar, Saibal |
| Active, not recruiting | N/A | 572 | Europe, Canada, US | TriClipTM Device | Abbott Medical Devices | Tricuspid Regurgitation | 11/22 | 04/29 | | |
NCT04029337: An Early Feasibility Study of the HighLife 28mm Trans-Septal Transcatheter Mitral Valve Replacement System |
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| Recruiting | N/A | 30 | US | Transcatheter Mitral Valve Replacement | HighLife SAS | Mitral Regurgitation | 12/24 | 12/27 | | |
| Recruiting | N/A | 250 | Europe, US | reSept ASD Occluder | atHeart Medical | Heart Septal Defect, Heart Septal Defects, Atrial, Heart Defects, Congenital, Cardiovascular Abnormalities, Cardiovascular Diseases, Heart Diseases, Congenital Abnormalities | 12/26 | 12/30 | | |
| Recruiting | N/A | 1247 | Europe, Canada, US | Edwards PASCAL System, Transcatheter Mitral Valve repair (TMVr), Abbott Mitraclip System | Edwards Lifesciences | Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation | 01/25 | 04/30 | | |
| Enrolling by invitation | N/A | 1500 | US | Experimental: Laminar Left Atrial Appendage Closure System, Active Comparator: WATCHMAN / Amulet | Laminar, Inc., Cardiovascular Research Foundation, New York | Non-valvular Atrial Fibrillation, Stroke | 08/28 | 02/32 | | |
| Recruiting | N/A | 25 | US | CardioMech MVRS | CardioMech AS | Mitral Regurgitation | 12/25 | 12/30 | | |
| Recruiting | N/A | 380 | Canada, US | Arm 1: treatment with Neovasc Reducer, Arm 2 (control): Implantation procedure with no device implanted, Arm 3 (unblinded, non-randomized): Single arm registry | Neovasc Inc., Shockwave Medical, Inc. | Refractory Angina | 06/25 | 12/28 | | |
NCT05565599: An Early Feasibility Study Evaluating the Safety and Efficacy of the Laminar Left Atrial Appendage Closure System in Subjects With Non-Valvular Atrial Fibrillation |
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| Active, not recruiting | N/A | 45 | US | Left Atrial Appendage Closure | Laminar, Inc. | Non-valvular Atrial Fibrillation | 08/24 | 09/29 | | |
NCT05913908: EFS of the DUO System for Tricuspid Regurgitation |
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| Recruiting | N/A | 15 | US | DUO Transcatheter Tricuspid Coaptation Valve System, DUO System | CroiValve Limited | Tricuspid Regurgitation, Tricuspid Valve Insufficiency, Tricuspid Valve Disease, Heart Valve Diseases | 12/25 | 10/29 | | |
NCT06212193: Innoventric Trillium™ Stent Graft Early Feasibility Study (EFS) |
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| Recruiting | N/A | 15 | US | Trillium™ | Innoventric LTD, Innoventric Inc. | Tricuspid Regurgitation, Tricuspid Regurgitation Functional | 08/25 | 08/30 | | |
| Active, not recruiting | N/A | 949 | US | WATCHMAN FLX Pro LAAC Device, Left Atrial Appendage Closure | Boston Scientific Corporation | Atrial Fibrillation, Bleeding, Stroke | 07/24 | 08/25 | | |
| Recruiting | N/A | 1857 | US | WATCHMAN FLX Pro LAAC Device, WATCHMAN FLX Pro Left Atrial Appendage Closure Device | Boston Scientific Corporation | Atrial Fibrillation, Stroke, Bleeding | 07/26 | 01/27 | | |
| Active, not recruiting | N/A | 102 | Europe, US | XIENCE Skypoint Large Vessel Everolimus Eluting Coronary Stent System (EECSS) | Abbott Medical Devices | Coronary Artery Disease | 08/25 | 08/27 | | |
| Recruiting | N/A | 15 | US | AltaValve | 4C Medical Technologies, Inc. | Mitral Regurgitation, Mitral Insufficiency, Mitral Valve Incompetence, Mitral Valve Regurgitation, Mitral Incompetence | 09/25 | 09/25 | | |
NCT05069558: Comparing PFO Outcomes of the Occlutech Flex II PFO Occluder to Standard of Care PFO Occlusion |
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| Active, not recruiting | N/A | 450 | Europe, Canada, US | Investigational PFO Closure Device, Standard of Care PFO Closure Device | Occlutech International AB | Stroke, Patent Foramen Ovale, PFO | 11/25 | 10/26 | | |
| Recruiting | N/A | 500 | Europe, Canada, US | MitraClip™ device implantation, Mitral Valve Repair Surgery | Abbott Medical Devices | Mitral Valve Regurgitation | 04/26 | 04/34 | | |
APOLLO, NCT03242642: Transcatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR System in Patients With Severe Symptomatic Mitral Regurgitation. |
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| Recruiting | N/A | 1056 | Europe, Canada, US | Medtronic Intrepid Transcatheter Mitral Valve Replacement System (TMVR) | Medtronic Cardiovascular | Mitral Valve Regurgitation | 10/26 | 09/36 | | |
| Active, not recruiting | N/A | 3000 | Europe, Canada, Japan, US, RoW | WATCHMAN FLX LAAC Device, WATCHMAN FLX Left Atrial Appendage Closure Device, Non-Vitamin K Oral Anticoagulant, NOAC | Boston Scientific Corporation | Atrial Fibrillation, Stroke, Bleeding | 12/27 | 12/27 | | |
NCT00573027: Heart Disease of the Small Arteries in Women and Men |
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| Recruiting | N/A | 634 | US | noninvasive tests | Cedars-Sinai Medical Center | Heart Disease | 01/40 | 01/40 | | |
| Al-Ahmad, Amin |
NCT03643224: DiamondTemp™ System for the Treatment of Persistent Atrial Fibrillation |
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| Completed | N/A | 376 | Europe, Canada, US, RoW | Radiofrequency Ablation | Medtronic Cardiac Rhythm and Heart Failure | Persistent Atrial Fibrillation, Atrial Fibrillation | 10/24 | 10/24 | | |
NCT04431544: AcQMap® US Registry of Procedural and Long-term Clinical Outcomes (Discover-US) |
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| Terminated | N/A | 513 | US | AcQMap System | Acutus Medical | Ablation of Arrhythmia's | 11/23 | 11/23 | | |
| Horton, Rodney |
| Recruiting | N/A | 475 | Europe, Canada, US | Amulet™ 2 Left Atrial Appendage (LAA) Occluder | Abbott Medical Devices | Atrial Fibrillation (AF), Stoke | 07/26 | 07/28 | | |
| Recruiting | N/A | 2650 | Europe, Canada, Japan, US, RoW | Left Atrial Appendage Occlusion (Amplatzer Amulet LAA Occluder), Amplatzer Amulet LAA Occluder, Non-Vitamin K Oral Antagonists, NOAC | Abbott Medical Devices | Atrial Fibrillation, Stroke, Bleeding | 08/27 | 08/30 | | |
NCT03643224: DiamondTemp™ System for the Treatment of Persistent Atrial Fibrillation |
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| Completed | N/A | 376 | Europe, Canada, US, RoW | Radiofrequency Ablation | Medtronic Cardiac Rhythm and Heart Failure | Persistent Atrial Fibrillation, Atrial Fibrillation | 10/24 | 10/24 | | |
| Cardinal, Deb |
REACT-AF, NCT05836987: The Rhythm Evaluation for AntiCoagulaTion With Continuous Monitoring of Atrial Fibrillation |
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| Recruiting | 3 | 5350 | US | AFSW Guided DOAC, Apple Watch, Continuous DOAC therapy, Oral Anticoagulation therapy | Johns Hopkins University, National Heart, Lung, and Blood Institute (NHLBI) | Atrial Fibrillation | 07/29 | 07/29 | | |
| Completed | N/A | 117 | US | Patient Preference Survey | Abbott Medical Devices | Cardiac Rhythm Disorder, Bradycardia, Cardiac Pacemaker Artificial | 06/23 | 06/23 | | |
| Active, not recruiting | N/A | 152 | Europe, US | ensoETM. Esophageal cooling during AF ablation, Esophageal temperature monitoring probe | Advanced Cooling Therapy, Inc., d/b/a Attune Medical, University of Pennsylvania, Berry Consultants, Texas Cardiac Arrhythmia Research Foundation, Beth Israel Deaconess Medical Center, Kansas City Cardiac Arrhythmia Research LLC | AF - Atrial Fibrillation, Complication, Atrio-Esophageal Fistula | 05/26 | 05/26 | | |
DISRUPT-AF, NCT06335082: A Registry Based Collaborative to Measure Efficiency, Effectiveness, and Safety of Farapulse PFA Technology for AF |
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| Enrolling by invitation | N/A | 2000 | US | Pulsed Field Ablation | Heart Rhythm Clinical and Research Solutions, LLC, Boston Scientific Corporation | Atrial Fibrillation | 11/26 | 01/27 | | |
ULTRA-HFIB, NCT04182620: Ultrasound-Based Renal Sympathetic Denervation as Adjunctive Upstream Therapy During Atrial Fibrillation Ablation |
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| Active, not recruiting | N/A | 160 | US | renal denervation, Catheter ablation | Vivek Reddy | Atrial Fibrillation | 03/25 | 03/25 | | |
| Recruiting | N/A | 300 | US | OPTIMIZER® Integra CCM-D System (Treatment Arm) | Impulse Dynamics | Heart Failure, Heart Failure with Reduced Ejection Fraction, Implantable Defibrillator User, CCM Therapy, Non-ischemic Cardiomyopathy, Ischemic Cardiomyopathy, Sudden Cardiac Arrest, Arrhythmias, Cardiac, Ventricular Tachycardia, Ventricular Fibrillation | 06/25 | 12/25 | | |
SAFFICIENT, NCT06488820: Safety and Efficacy of Pulsed-field Ablation for Atrial Fibrillation in High Versus Low-volume Ablation Centers |
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| Recruiting | N/A | 2276 | US | Catheter ablation using pulsed-field ablation (PFA) system | Texas Cardiac Arrhythmia Research Foundation | Atrial Fibrillation | 08/26 | 08/27 | | |
| Recruiting | N/A | 1857 | US | WATCHMAN FLX Pro LAAC Device, WATCHMAN FLX Pro Left Atrial Appendage Closure Device | Boston Scientific Corporation | Atrial Fibrillation, Stroke, Bleeding | 07/26 | 01/27 | | |
| Recruiting | N/A | 475 | Europe, Canada, US | Amulet™ 2 Left Atrial Appendage (LAA) Occluder | Abbott Medical Devices | Atrial Fibrillation (AF), Stoke | 07/26 | 07/28 | | |
| Recruiting | N/A | 2650 | Europe, Canada, Japan, US, RoW | Left Atrial Appendage Occlusion (Amplatzer Amulet LAA Occluder), Amplatzer Amulet LAA Occluder, Non-Vitamin K Oral Antagonists, NOAC | Abbott Medical Devices | Atrial Fibrillation, Stroke, Bleeding | 08/27 | 08/30 | | |
NCT03643224: DiamondTemp™ System for the Treatment of Persistent Atrial Fibrillation |
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| Completed | N/A | 376 | Europe, Canada, US, RoW | Radiofrequency Ablation | Medtronic Cardiac Rhythm and Heart Failure | Persistent Atrial Fibrillation, Atrial Fibrillation | 10/24 | 10/24 | | |
| Recruiting | N/A | 1500 | US | Cardiac Contractility Modulation Therapy via OPTIMIZER™ Smart Mini System, CCM Group (CCM ON), OPTIMIZER™ Smart Mini System, Sham Group (CCM OFF) | Impulse Dynamics | Heart Failure, Heart Failure with Preserved Ejection Fraction, Heart Failure with Mid Range Ejection Fraction, Heart Failure with Moderately Reduced Ejection Fraction, Diastolic Heart Failure | 02/25 | 02/26 | | |
NCT03970343: Post Approval Study (PAS) of the OPTIMIZER Smart and CCM Therapy |
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| Recruiting | N/A | 620 | US | OPTIMIZER Smart System | Impulse Dynamics | Heart Failure | 03/26 | 03/26 | | |
| Recruiting | N/A | 142 | Europe, US | AtriCure ISOLATOR Synergy Surgical Ablation System | AtriCure, Inc. | Inappropriate Sinus Tachycardia | 06/26 | 06/27 | | |
| Martucci, Michele |
REACT-AF, NCT05836987: The Rhythm Evaluation for AntiCoagulaTion With Continuous Monitoring of Atrial Fibrillation |
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| Recruiting | 3 | 5350 | US | AFSW Guided DOAC, Apple Watch, Continuous DOAC therapy, Oral Anticoagulation therapy | Johns Hopkins University, National Heart, Lung, and Blood Institute (NHLBI) | Atrial Fibrillation | 07/29 | 07/29 | | |
AVANT GUARD, NCT06096337: Pulsed Field Ablation (PFA) Vs Anti-Arrhythmic Drug (AAD) Therapy As a First Line Treatment for Persistent Atrial Fibrillation |
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| Recruiting | N/A | 520 | Europe, Canada, US, RoW | FARAPULSE™ Pulsed Field Ablation (PFA) System, Anti-Arrhythmic Drug (AAD): Flecainide, Sotalol, Propafenone, Dofetilide, and Dronedarone | Boston Scientific Corporation | Persistent Atrial Fibrillation | 12/25 | 12/27 | | |
| Active, not recruiting | N/A | 200 | Europe, Canada, US | Adagio AF Cryoablation System (iCLAS™) | Adagio Medical | Persistent Atrial Fibrillation | 08/23 | 08/24 | | |
| Howe, Autumn |
CHANGE AFIB, NCT05130268: Early Dronedarone Versus Usual Care to Improve Outcomes in Persons With Newly Diagnosed Atrial Fibrillation |
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| Completed | 4 | 339 | US | Dronedarone, Multaq | American Heart Association, Duke Clinical Research Institute, Sanofi | Atrial Fibrillation | 01/24 | 06/24 | | |
| Active, not recruiting | 3 | 14013 | Europe, Canada, US, RoW | Inclisiran sodium 300 mg (equivalent to 284 mg inclisiran) in 1.5 mL, KJX839, Placebo in 1.5ml | Novartis Pharmaceuticals | Primary Prevention of Atherosclerotic Cardiovascular Disease | 04/29 | 04/29 | | |
REACT-AF, NCT05836987: The Rhythm Evaluation for AntiCoagulaTion With Continuous Monitoring of Atrial Fibrillation |
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| Recruiting | 3 | 5350 | US | AFSW Guided DOAC, Apple Watch, Continuous DOAC therapy, Oral Anticoagulation therapy | Johns Hopkins University, National Heart, Lung, and Blood Institute (NHLBI) | Atrial Fibrillation | 07/29 | 07/29 | | |
CREDIBLE, NCT06424119: Multi-Center Study of Clinical and Inflammatory Outcomes in Intensive Cardiac Rehabilitation and Traditional Cardiac Rehabilitation Programs |
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| Recruiting | N/A | 450 | US | Traditional Cardiac Rehabilitation, TCR, Intensive Cardiac Rehabilitation, ICR, C2life® Food | Pritikin ICR, Ballad Health, Mission Health System, Asheville, NC, Trinity Health, Connecting Health Innovation | Cardiovascular Diseases | 06/26 | 12/27 | | |
| Recruiting | N/A | 1500 | US | Cardiac Contractility Modulation Therapy via OPTIMIZER™ Smart Mini System, CCM Group (CCM ON), OPTIMIZER™ Smart Mini System, Sham Group (CCM OFF) | Impulse Dynamics | Heart Failure, Heart Failure with Preserved Ejection Fraction, Heart Failure with Mid Range Ejection Fraction, Heart Failure with Moderately Reduced Ejection Fraction, Diastolic Heart Failure | 02/25 | 02/26 | | |
NCT03970343: Post Approval Study (PAS) of the OPTIMIZER Smart and CCM Therapy |
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| Recruiting | N/A | 620 | US | OPTIMIZER Smart System | Impulse Dynamics | Heart Failure | 03/26 | 03/26 | | |
| Meyers, Jason |
NCT03505801: Confirm Rx Insertable Cardiac Monitor SMART Registry |
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| Active, not recruiting | N/A | 1826 | Europe, Canada, Japan, US, RoW | Confirm Rx ICM insertion procedure | Abbott Medical Devices | Cardiac Arrhythmias, Symptoms and Signs, Atrial Fibrillation | 09/19 | 03/26 | | |
AVANT GUARD, NCT06096337: Pulsed Field Ablation (PFA) Vs Anti-Arrhythmic Drug (AAD) Therapy As a First Line Treatment for Persistent Atrial Fibrillation |
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| Recruiting | N/A | 520 | Europe, Canada, US, RoW | FARAPULSE™ Pulsed Field Ablation (PFA) System, Anti-Arrhythmic Drug (AAD): Flecainide, Sotalol, Propafenone, Dofetilide, and Dronedarone | Boston Scientific Corporation | Persistent Atrial Fibrillation | 12/25 | 12/27 | | |
NCT03643224: DiamondTemp™ System for the Treatment of Persistent Atrial Fibrillation |
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| Completed | N/A | 376 | Europe, Canada, US, RoW | Radiofrequency Ablation | Medtronic Cardiac Rhythm and Heart Failure | Persistent Atrial Fibrillation, Atrial Fibrillation | 10/24 | 10/24 | | |
| Canby, Robert |
| Completed | N/A | 117 | US | Patient Preference Survey | Abbott Medical Devices | Cardiac Rhythm Disorder, Bradycardia, Cardiac Pacemaker Artificial | 06/23 | 06/23 | | |
| Recruiting | N/A | 300 | US | OPTIMIZER® Integra CCM-D System (Treatment Arm) | Impulse Dynamics | Heart Failure, Heart Failure with Reduced Ejection Fraction, Implantable Defibrillator User, CCM Therapy, Non-ischemic Cardiomyopathy, Ischemic Cardiomyopathy, Sudden Cardiac Arrest, Arrhythmias, Cardiac, Ventricular Tachycardia, Ventricular Fibrillation | 06/25 | 12/25 | | |
| Active, not recruiting | N/A | 93 | US | BATwire Implant Kit | CVRx, Inc. | Heart Failure | 08/24 | 07/25 | | |
| Completed | N/A | 61 | US | Enabling Sensor Research Holter Mode feature | Medtronic Cardiac Rhythm and Heart Failure | Heart Failure | 06/24 | 06/24 | | |
NCT04496518: Personalized Therapy Study - Intrinsic Antitachycardia Pacing Post-Approval Study (iATP PAS) |
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| Active, not recruiting | N/A | 2200 | Europe, US | Intrinsic Antitachycardia Pacing (iATP) Therapy | Medtronic | Ventricular Tachycardia | 01/25 | 01/27 | | |
NCT04489225: Personalized Therapy Study - HFRS (TriageHF) Post Approval Study |
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| Active, not recruiting | N/A | 2200 | Europe, US | Observational | Medtronic | Heart Failure | 01/25 | 01/27 | | |
