University of Pennsylvania Medical Center
Welcome,         Profile    Billing    Logout  
 42 Trials 
98 Trials

   

 
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Snyder, Peter
ARIAS, NCT03862222: Atlas of Retinal Imaging in Alzheimer's Study

Recruiting
N/A
330
US
Retinal Imaging, Pupillometry, Contrast Sensitivity, Neuropsychological Evaluation, APOE genotyping, blood draw, Gait Assessment, Timed Up and Go, Timed Up and Go - Dual Task (TUG, TUG-DT), Actigraphy
University of Rhode Island, Stuart Sinoff, MD, Peter J Snyder, MD, BayCare Health System
Alzheimer Disease, Mild Cognitive Impairment, Mild Dementia, Aging, Cognitive Change
12/21
06/25
LINC6, NCT05382156: Non-interventional Study on Osilodrostat in Patients With Endogenous Cushing's Syndrome

Active, not recruiting
N/A
206
Europe, US
Osilodrostat, Isturisa
RECORDATI GROUP
Endogenous Cushing's Syndrome
06/27
08/27
Sterman, Daniel H
INFINITE, NCT03710876 / 2017-003169-82: Efficacy & Safety of RAd-IFN Administered with Celecoxib & Gemcitabine in Patients with Malignant Pleural Mesothelioma

Active, not recruiting
3
53
Europe, Canada, US, RoW
rAd-IFN, Nadofaragene firadenovec, Celecoxib Oral Product, COX II Inhibitor, Gemcitabine, Chemotherapy
Ferring Ventures Limited, University of Pennsylvania
Malignant Pleural Mesothelioma
03/24
04/26
IMPRINT-Lung, NCT03634241: Pembrolizumab in Preventing Lung Cancer in Patients With Stage I-II Non-Small Cell Lung Cancer or High-Risk Pulmonary Nodules, the Study

Recruiting
2
48
US
Pembrolizumab, Keytruda, Lambrolizumab, MK-3475, SCH 900475, Quality-of-Life Assessment, Quality of Life Assessment, Computed Tomography, CAT, CAT Scan, Computed Axial Tomography, computerized axial tomography, Computerized Axial, Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection
M.D. Anderson Cancer Center
Lung Non-Small Cell Carcinoma, Stage I Lung Cancer AJCC v8, Stage IA1 Lung Cancer AJCC v8, Stage IA2 Lung Cancer AJCC v8, Stage IA3 Lung Cancer AJCC v8, Stage IB Lung Cancer AJCC v8, Stage II Lung Cancer AJCC v8, Stage IIA Lung Cancer AJCC v8, Stage IIB Lung Cancer AJCC v8
12/25
12/25
LuTK02, NCT04495153: CAN-2409 Plus Prodrug With Standard of Care Immune Checkpoint Inhibitor for Stage III/IV NSCLC

Active, not recruiting
2
90
US
Aglatimagene besadenovec, CAN-2409, AdV-tk
Candel Therapeutics, Inc., NYU Langone Health
Non Small Cell Lung Cancer
12/24
12/26
NCT04049474: Bronchoscopic Cryo-Immunotherapy of Lung Cancer

Completed
1
21
US
ERBOKRYO® CA - Cryosurgical Unit with Flexible ERBECRYO Probe, 1.9 mm outer diameter (ERBE Inc., Tubingen, Germany)
NYU Langone Health
Advanced Non-small Cell Lung Cancer
04/24
04/24
Ramalingam, Suresh
LAURA, NCT03521154 / 2018-001061-16: A Global Study to Assess the Effects of Osimertinib Following Chemoradiation in Patients With Stage III Unresectable Non-small Cell Lung Cancer

Hourglass Jan 2022 - Dec 2023 : Acceptance of regulatory submission in US (based on LAURA trial) for unresectable NSCLC
Hourglass Jan 2022 - Dec 2023 : From LAURA trial for unresectable EGFRm stage III NSCLC
Active, not recruiting
3
216
Europe, Japan, US, RoW
Osimertinib 80mg/40mg, Placebo Osimertinib 80mg/40mg
AstraZeneca
Non Small Cell Lung Cancer (Stage III)
01/24
06/26
TROPION-Lung10, NCT06357533: Phase III, Open-label, Study of First-line Dato-DXd in Combination With Rilvegostomig for Advanced Non-squamous NSCLC With High PD-L1 Expression (TC ≥ 50%) and Without Actionable Genomic Alterations

Recruiting
3
675
Europe, Canada, Japan, US, RoW
Datopotamab Deruxtecan, Dato-DXd, Rilvegostomig, AZD2936, Pembrolizumab, KEYTRUDA
AstraZeneca, Daiichi Sankyo
Non-Small Cell Lung Cancer
04/28
05/30
NCT03847519: Study of ADXS-503 With or Without Pembro in Subjects With Metastatic Non-Small Cell Lung Cancer

Completed
1/2
24
US
ADXS-503, Lm immunotherapy, A503, Pembrolizumab, Keytruda, pembro
Advaxis, Inc.
Lung Cancer, Non-Small Cell, Metastatic Squamous Cell Carcinoma, Metastatic Non-Squamous Cell Carcinoma
02/22
02/22
NCT03917381 / 2018-003402-63: GEN1046 Safety Trial in Patients With Malignant Solid Tumors

Active, not recruiting
1/2
429
Europe, US, RoW
Acasunlimab, GEN1046, DuoBody®-PD-L1x4-1BB, Acasunlimab in combination with docetaxel (in a single expansion cohort), Acasunlimab in combination with pembrolizumab (in a separate expansion cohort), Acasunlimab in combination with pembrolizumab and standard chemotherapy (in separate expansion cohorts)
Genmab, BioNTech SE
Solid Tumors, Non-small Cell Lung Cancer, Urothelial Carcinoma, Endometrial Carcinoma, Triple Negative Breast Cancer, Squamous Cell Carcinoma of the Head and Neck, Cervical Cancer
02/26
02/26
NCT05493566: Low-Dose Interleukin-2 and Pembrolizumab for the Treatment of Stage IV Non-Small Cell Lung Cancer

Recruiting
1
15
US
Aldesleukin, 125-L-Serine-2-133-interleukin 2, Proleukin, r-serHuIL-2, Recombinant Human IL-2, Recombinant Human Interleukin-2, Pembrolizumab, Keytruda, Lambrolizumab, MK-3475, SCH 900475
Emory University, National Cancer Institute (NCI)
Lung Non-Small Cell Carcinoma, Stage IV Lung Cancer AJCC v8, Stage IVA Lung Cancer AJCC v8, Stage IVB Lung Cancer AJCC v8
01/25
01/26
Shaked, Abraham
ELIMINATE, NCT06280950: Expanding Liver Transplant Immunosuppression Minimization Via Everolimus

Recruiting
2
340
US
Everolimus, Zortress, Tacrolimus (continued reduction), FK-506, FR-900506, Prograf, Prograft, Tacrolimus (maintain 50% reduction)
National Institute of Allergy and Infectious Diseases (NIAID)
Liver Transplant
06/27
06/29
Barnhart, Kurt T
APPLE, NCT06408181: Aspirin to Prevent Pregnancy Loss and Preeclampsia

Recruiting
3
1150
US
Aspirin 162 mg, acetylsalicylic acid, ASA, Aspirin 81mg
University of Pennsylvania, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Pre-Eclampsia, Pregnancy Loss
06/29
06/29
Karakousis, Giorgos
NCT04950166: A Study to Evaluate ONM100, an Intraoperative Fluor Imaging Agent for the Detection of Peri Mets

Completed
2
51
US
pegsitacianine, ONM-100
OncoNano Medicine, Inc.
Peritoneal Carcinomatosis
12/22
01/23
NCT03757689: Neoadjuvant PD-1 Blockade in Patients With Stage IIB/C Melanoma

Active, not recruiting
2
63
US
Pembrolizumab, Wide Excision and Sentinel Lymph Node (SLN) Biopsy
Abramson Cancer Center at Penn Medicine
Melanoma
12/24
02/26
Townsend, Raymond R
BLOCK HFpEF, NCT04434664: BLOCKade of Calcium Channels and Beta Adrenergic Receptors for the Treatment of Hypertension in HFpEF

Completed
4
50
US
Amlodipine Besylate, Metoprolol Succinate
University of Pennsylvania, Julio Chirinos, MD, PhD, Raymond Townsend, MD
Heart Failure with Preserved Ejection Fraction, Hypertension
12/24
12/24
NCT02439749: SPYRAL PIVOTAL - SPYRAL HTN-OFF MED Study

Completed
N/A
366
Europe, Canada, Japan, US, RoW
Symplicity Spyral™ multi-electrode renal denervation system, Renal angiography, Renal Denervation, Sham Procedure
Medtronic Vascular
Hypertension, Vascular Diseases, Cardiovascular Diseases
04/20
10/23
PISA-BP, NCT03176732: Mechanisms for Individual Differences in Hypertension in Obstructive Sleep

Completed
N/A
155
US, RoW
Positive Airway Pressure
University of Pennsylvania, National Institutes of Health (NIH), National Heart, Lung, and Blood Institute (NHLBI)
Sleep Apnea, Obstructive, Hypertension
04/22
06/22
NCT02439775: SPYRAL HTN-ON MED Study of Renal Denervation With the Symplicity Spyral™ Multi-electrode Renal Denervation System

Active, not recruiting
N/A
337
Europe, Canada, Japan, US, RoW
Symplicity Spyral™ multi-electrode renal denervation system, Renal angiography, Renal Denervation, Sham Procedure
Medtronic Vascular
Hypertension, Vascular Diseases, Cardiovascular Diseases
08/22
10/25
NCT03598894: Hypertension Chronobiome

Recruiting
N/A
150
US
Ambulatory blood pressure measurements
University of Pennsylvania
Hypertension
05/26
05/28
Ben-Josef, Edgar
NCT05488522: SBRT With Atezo/Bev for HCC

Recruiting
1
18
US
SBRT + atezolizumab and bevacizumab
Abramson Cancer Center at Penn Medicine
Hepatocellular Carcinoma
12/24
12/26
NCT02207465: A Phase I Dual Dose Escalation Study of Radiation and Nab-Paclitaxel in Patients With Unresectable and Borderline Resectable Pancreatic Cancer

Recruiting
1
42
US
Radiotherapy, Abraxane, nab-paclitaxel
Abramson Cancer Center at Penn Medicine
Locally Advanced Unresectable Pancreatic Cancer Treated With Chemoradiotherapy, Borderline Resectable Pancreatic Cancer Treated With Chemoradiotherapy
12/25
12/25
NCT01918683: TACE With or Without SBRT as Bridging Therapy for Pre-transplant HCC Patients

Active, not recruiting
N/A
40
US
TACE transarterial chemoembolization, stereotatic body radiotherapy (SBRT)
Abramson Cancer Center at Penn Medicine, Loyola University, Oregon Health and Science University
Hepatocellular Carcinoma
12/26
12/27
Cohen, Adam
EF-41, NCT06556563: /KEYNOTE D58: Phase 3 Study of Optune Concomitant With Temozolomide Plus Pembrolizumab in Newly Diagnosed Glioblastoma

Recruiting
3
741
Japan, US
Optune® device, TTFields, Temozolomide, Pembrolizumab, Placebo
NovoCure GmbH, Merck Sharp & Dohme LLC
Glioblastoma
04/29
04/29
ACTION, NCT05580562: ONC201 in H3 K27M-mutant Diffuse Glioma Following Radiotherapy (the Study)

Calendar Jan 2026 - Dec 2026: Final data from ACTION trial for newly diagnosed H3 K27M-mutant diffuse glioma
Calendar Jan 2025 - Mar 2025: Interim data from ACTION trial for newly diagnosed H3 K27M-mutant diffuse glioma
Recruiting
3
450
Europe, Canada, Japan, US, RoW
Dordaviprone (ONC201), Dordaviprone (ONC201) + Placebo, Placebo
Chimerix
H3 K27M, Glioma
08/26
08/26
NRG-BN011, NCT05095376: Testing the Addition of the Chemotherapy Drug Lomustine (Gleostine®) to the Usual Treatment (Temozolomide and Radiation Therapy) for Newly Diagnosed MGMT Methylated Glioblastoma

Recruiting
3
306
Canada, US
Lomustine, 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea, 1-Nitrosourea, 1-(2-chloroethyl)-3-cyclohexyl-, Belustin, Belustine, CCNU, Cecenu, CeeNU, Chloroethylcyclohexylnitrosourea, Citostal, Gleostine, Lomeblastin, Lomustinum, Lucostin, Lucostine, N-(2-Chloroethyl)-N'-cyclohexyl-N-nitrosourea, Prava, RB-1509, WR-139017, Photon Beam Radiation Therapy, Photon EBRT, Photon External Beam Radiotherapy, Radiation, Photon Beam, Quality-of-Life Assessment, Quality of Life Assessment, Questionnaire Administration, Temozolomide, CCRG-81045, Imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3, 4-dihydro-3-methyl-4-oxo-, M & B 39831, M and B 39831, Methazolastone, RP-46161, SCH 52365, Temcad, Temodal, Temodar, Temomedac, TMZ
NRG Oncology, National Cancer Institute (NCI)
Glioblastoma, Gliosarcoma
08/26
08/31
NCT03224767: Vemurafenib and Cobimetinib in Treating Patients with BRAF V600E Mutation Positive Craniopharyngioma

Active, not recruiting
2
24
US
Vemurafenib, Cobimetinib, Laboratory Biomarker Analysis, Quality-of-Life Assessment
Alliance for Clinical Trials in Oncology, National Cancer Institute (NCI)
BRAF V600E Mutation Present, Papillary Craniopharyngioma
10/26
08/28
NCT04145115: A Study Testing the Effect of Immunotherapy (Ipilimumab and Nivolumab) in Patients With Recurrent Glioma With Elevated Mutational Burden

Suspended
2
37
US
Ipilimumab, Anti-Cytotoxic T-Lymphocyte-Associated Antigen-4 Monoclonal Antibody, BMS 734016, BMS-734016, BMS734016, Ipilimumab Biosimilar CS1002, MDX 010, MDX-010, MDX-CTLA4, MDX010, Yervoy, Magnetic Resonance Imaging, Magnetic Resonance, Magnetic Resonance Imaging (MRI), Magnetic resonance imaging (procedure), Magnetic Resonance Imaging Scan, Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance, MR, MR Imaging, MRI, MRI Scan, MRIs, NMR Imaging, NMRI, Nuclear Magnetic Resonance Imaging, sMRI, Structural MRI, Nivolumab, ABP 206, BCD-263, BMS 936558, BMS-936558, BMS936558, CMAB819, MDX 1106, MDX-1106, MDX1106, NIVO, Nivolumab Biosimilar ABP 206, Nivolumab Biosimilar BCD-263, Nivolumab Biosimilar CMAB819, ONO 4538, ONO-4538, ONO4538, Opdivo
National Cancer Institute (NCI)
Astrocytoma, IDH-Mutant, Grade 4, Diffuse Glioma, Glioblastoma, IDH-Wildtype, Secondary Glioblastoma
05/25
05/25
A071401, NCT02523014: Vismodegib, FAK Inhibitor GSK2256098, Capivasertib, and Abemaciclib in Treating Patients with Progressive Meningiomas

Recruiting
2
124
US
Vismodegib, GDC-0449, FAK Inhibitor GSK2256098, Capivasertib, AZD5363, Abemaciclib
Alliance for Clinical Trials in Oncology, National Cancer Institute (NCI), GlaxoSmithKline, Genentech, Inc., Brain Science Foundation
Intracranial Meningioma, Recurrent Meningioma, NF2 Gene Mutation
01/26
01/28
NCT06325683: Anti-Lag-3 (Relatlimab) and Anti-PD-1 Blockade (Nivolumab) Versus Standard of Care (Lomustine) for the Treatment of Patients With Recurrent Glioblastoma

Suspended
2
184
US
Biopsy, BIOPSY_TYPE, Bx, Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Lomustine, 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea, 1-Nitrosourea, 1-(2-chloroethyl)-3-cyclohexyl-, Belustin, Belustine, CCNU, Cecenu, CeeNU, Chloroethylcyclohexylnitrosourea, Citostal, Gleostine, Lomeblastin, Lomustinum, Lucostin, Lucostine, N-(2-Chloroethyl)-N'-cyclohexyl-N-nitrosourea, Prava, RB-1509, WR-139017, Magnetic Resonance Imaging, Magnetic Resonance, Magnetic Resonance Imaging (MRI), Magnetic resonance imaging (procedure), Magnetic Resonance Imaging Scan, Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance, MR, MR Imaging, MRI, MRI Scan, MRIs, NMR Imaging, NMRI, Nuclear Magnetic Resonance Imaging, sMRI, Structural MRI, Nivolumab, ABP 206, BCD-263, BMS 936558, BMS-936558, BMS936558, CMAB819, MDX 1106, MDX-1106, MDX1106, NIVO, Nivolumab Biosimilar ABP 206, Nivolumab Biosimilar BCD-263, Nivolumab Biosimilar CMAB819, ONO 4538, ONO-4538, ONO4538, Opdivo, Relatlimab, BMS 986016, BMS-986016, BMS986016, Immunoglobulin G4, Anti-(human Lymphocyte Activation Gene-3 Protein) (Human Heavy Chain), Disulfide with Human Light Chain, Dimer, Surgical Procedure, Operation, Surgery, Surgery Type, Surgery, NOS, Surgical, Surgical Intervention, Surgical Interventions, Surgical Procedures, Type of Surgery
National Cancer Institute (NCI)
Recurrent Glioblastoma
07/28
07/28
NRG-BN010, NCT04729959: Testing the Addition of the Immune Therapy Drugs, Tocilizumab and Atezolizumab, to Radiation Therapy for Recurrent Glioblastoma

Active, not recruiting
2
53
US
Atezolizumab, MPDL 3280A, MPDL 328OA, MPDL-3280A, MPDL3280A, MPDL328OA, RG 7446, RG-7446, RG7446, RO 5541267, RO-5541267, RO5541267, Tecentriq, Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Conventional Surgery, Fractionated Stereotactic Radiation Therapy, Fractionated Stereotactic Radiotherapy, Magnetic Resonance Imaging, Magnetic Resonance, Magnetic Resonance Imaging (MRI), Magnetic resonance imaging (procedure), Magnetic Resonance Imaging Scan, Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance, MR, MR Imaging, MRI, MRI Scan, MRIs, NMR Imaging, NMRI, Nuclear Magnetic Resonance Imaging, sMRI, Structural MRI, Tocilizumab, Actemra, IL-6 receptor monoclonal antibodies: tocilizumab, Immunoglobulin G1, Anti-(Human Interleukin 6 Receptor) (Human-Mouse Monoclonal MRA Heavy Chain), Disulfide with Human-Mouse Monoclonal MRA Kappa-Chain, Dimer, MRA, R-1569, RoActemra
National Cancer Institute (NCI), NRG Oncology
Diffuse Astrocytoma, IDH-Wildtype, Recurrent Glioblastoma
08/25
08/25
RESTORE, NCT03862430: A Study of NanO2™ Combined With Radiation and Temozolomide in Patients With Newly Diagnosed GBM

Recruiting
2
87
US
NanO2TM, Dodecafluoropentane emulsion (DDFPe), Placebo Saline Infusion, 0.9N NaCl
NuvOx LLC
Glioblastoma Multiforme
06/25
09/25
SPOCK, NCT04965688: Systems Biology Guided Therapy for Breast Cancer Positive for Oestrogen Receptor After Aromatase Inhibitor and CDK Inhibition

Terminated
2
2
US
Drug determined by treating oncologist based on recommendation from systems biology analysis.
Inova Health Care Services, City of Hope Medical Center
Breast Cancer, Estrogen Receptor-positive Breast Cancer, HER2-negative Breast Cancer
03/24
03/24
BPM31510IV-11, NCT04752813: A Study of BPM31510 with Vitamin K1 in Subjects with Newly Diagnosed Glioblastoma (GB)

Recruiting
2
50
US
BPM31510, Vitamin K1, Temozolomide (TMZ), Radiation
BPGbio, BPGbio
Glioblastoma, Glioblastoma Multiforme
02/25
12/25
NCT04680468: Study of Belantamab Mafodotin as Pre- and Post-autologous Stem Cell Transplant and Maintenance for Multiple Myeloma

Recruiting
2
47
US
Belantamab mafodotin, GSK2857916
University of Pennsylvania, GlaxoSmithKline
Myeloma
07/26
07/26
NCT05801939: Cevostamab Following CAR T Cell Therapy for RRMM

Recruiting
2
30
US
Cevostamab
University of Pennsylvania, Genentech, Inc.
Relapsed/Refractory Multiple Myeloma
05/27
05/28
CHARGE, NCT04315233: Ribociclib&Belinostat In Patients w Metastatic Triple Neg Breast Cancer & Recurrent Ovarian Cancer w Response Prediction By Genomics

Recruiting
1
34
US
Ribociclib, Belinostat
University of Utah, Novartis, Acrotech Biopharma
Metastatic Breast Cancer, Recurrent Ovarian Carcinoma
04/24
08/26
ACT I, NCT05519774: Assessment of Cancer Related Brain Fog Using the Test of Strategic Learning

Active, not recruiting
N/A
54
US
Inova Health Care Services, The University of Texas at Dallas
Brain Fog
06/24
01/25
Cucchiara, Brett
CAPTIVA, NCT05047172: Comparison of Anti-coagulation and Anti-Platelet Therapies for Intracranial Vascular Atherostenosis

Recruiting
3
1683
US
Ticagrelor + Aspirin, Brilinta, Rivaroxaban + Aspirin, Xarelto, Clopidogrel + Aspirin, Plavix, Risk Factor Management
University of Florida, National Institute of Neurological Disorders and Stroke (NINDS), University of Cincinnati, Medical University of South Carolina, Janssen Scientific Affairs, LLC, AstraZeneca
Intracranial Arteriosclerosis, Stroke
05/28
05/28
NCT04129125: The Imperative Trial: Treatment of Acute Ischemic Stroke With the Zoom Reperfusion System

Completed
N/A
328
US
Zoom Reperfusion System
Imperative Care, Inc.
Ischemic Stroke, Acute Stroke
05/24
05/24
CREST-2, NCT02089217: Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial

Active, not recruiting
N/A
2486
Europe, Canada, US, RoW
Carotid endarterectomy (CEA), Carotid Stenting (CAS), Intensive Medical Management - no CEA, Intensive Medical Management - no CAS
Thomas G. Brott, M.D., National Institute of Neurological Disorders and Stroke (NINDS)
Carotid Stenosis
02/26
02/26
Schuster, James
NCT03418753: Non-invasive Diagnostic for Assessing Elevated Intracranial Pressure

Completed
N/A
60
US
EyeBOX for ICP
Oculogica, Inc.
Intracranial Pressure Increase
05/23
05/23
MTRON, NCT02830451: Metastatic Tumor Research and Outcomes Network

Recruiting
N/A
960
Europe, Canada, Japan, US, RoW
AO Innovation Translation Center, AO Foundation, AO Spine
Metastatic Spine Tumor
12/25
12/25
Frankel, David
LESS-VT, NCT03490201: FLExAbility Sensor Enabled Substrate Targeted Ablation for the Reduction of VT Study

Completed
N/A
592
Europe, US, RoW
Market Approved RF Ablation System, FlexAbility SE Ablation Catheter
Abbott Medical Devices
Ventricular Tachycardia
04/24
04/24
DEFINE AFib, NCT04926857: (Atrial Fibrillation)

Completed
N/A
973
US
Non-Interventional
Medtronic Cardiac Rhythm and Heart Failure
Atrial Fibrillation
01/24
01/24
Dorgan, Daniel
Tailwind, NCT05616221: Study to Evaluate the Safety, Phage Kinetics, and Efficacy of Inhaled AP-PA02 in Subjects With Non-Cystic Fibrosis Bronchiectasis and Chronic Pulmonary Pseudomonas Aeruginosa Infection

Completed
2
48
US
AP-PA02, Placebo
Armata Pharmaceuticals, Inc.
Non-cystic Fibrosis Bronchiectasis, Pseudomonas Aeruginosa, Lung Infection
07/24
08/24
NCT06159725: A Study to Evaluate the Safety of CMTX-101 in People with Cystic Fibrosis

Recruiting
1/2
41
US
CMTX-101, Placebo
Clarametyx Biosciences, Inc.
Persistent Infection, Cystic Fibrosis
08/25
08/25
AEROW, NCT05248230: 4D-710 in Adult Patients with Cystic Fibrosis

Recruiting
1/2
40
US
4D-710
4D Molecular Therapeutics
Cystic Fibrosis Lung
12/26
01/30
SAAVe, NCT06526923: A Phase 1/2 Trial of SP-101 for the Treatment of Cystic Fibrosis (CF)

Recruiting
1/2
15
US
SP-101 and doxorubicin Cohort 1, SP-101, doxorubicin, SP-101 and doxorubicin Cohort 2
Spirovant Sciences, Inc.
Cystic Fibrosis
12/26
12/26
NCT06016088: A Double-Blind, Active-Controlled, Multiple-Ascending Dose Study of Aerosolized RSP-1502 in Subjects With CF and Chronic PA Lung Infection

Recruiting
1/2
72
US, RoW
RSP-1502, Tobramycin inhalation solution
Respirion Pharmaceuticals Pty Ltd
Cystic Fibrosis Lung, Respiratory Infections, Recurrent, Chronic, Pseudomonas Aeruginosa
12/25
12/25
NICE-CF, NCT05362344: Colorectal Cancer Screening in Cystic Fibrosis

Active, not recruiting
N/A
350
US
Stool tests, Stool-based Fecal Immunochemical Testing (FIT) test and Stool-based DNA test (Cologuard) test.
University of Washington, the Collaborative Health Studies Coordinating Center, Cystic Fibrosis Foundation
Cystic Fibrosis, Colorectal Cancer, Adenoma
03/25
06/25
Kasner, Scott E
MOST, NCT03735979: Multi-arm Optimization of Stroke Thrombolysis

Active, not recruiting
3
514
US
Argatroban, Eptifibatide, Placebo
Washington University School of Medicine, National Institute of Neurological Disorders and Stroke (NINDS)
Acute Ischemic Stroke
12/23
04/25
ReMEDy2, NCT05065216: Treatment of Acute Ischemic Stroke ( Trial)

Recruiting
2/3
728
US
Recombinant human tissue kallikrein, DM199, Placebo for DM199 Solution for Injection
DiaMedica Therapeutics Inc
Acute Stroke, Ischemic Stroke, Stroke
12/26
12/26
PRESTA, NCT05140148: Promoting Recovery After STroke With Amantadine

Recruiting
2
60
US
Amantadine, Placebo
University of Pennsylvania
Stroke, Ischemic, Stroke Hemorrhagic
12/25
06/26
NCT06368193: The Neuralert Stroke Monitor Pilot Trial

Recruiting
2
20
US
Neuralert Monitor
Neuralert Technologies LLC
Stroke, Surgery
05/26
05/27
NCT02642744: Improving Coordination and Transitions of Care in Stroke Patients

Completed
N/A
670
US
Nursing care model
University of Pennsylvania
Stroke, Transient Ischemic Attack
09/17
12/23
DISCOVERY, NCT04916210: Determinants of Incident Stroke Cognitive Outcomes and Vascular Effects on RecoverY

Recruiting
N/A
8000
US
Massachusetts General Hospital, National Institute of Neurological Disorders and Stroke (NINDS)
Ischemic Stroke, Intracerebral Hemorrhage, Subarachnoid Hemorrhage, Dementia, Vascular, Mild Cognitive Impairment, Vascular Cognitive Impairment
11/25
11/25
Messe, Steven
NCT02864953 / 2017-004854-41: Phase 3 Study to Evaluate the Efficacy and Safety of Intravenous BIIB093 (Glibenclamide) for Severe Cerebral Edema Following Large Hemispheric Infarction

Terminated
3
535
Europe, Canada, Japan, US, RoW
BIIB093, glibenclamide, glibenclamide intravenous (IV), glyburide, CIRARA, Placebo
Remedy Pharmaceuticals, Inc.
Brain Edema, Stroke, Acute
08/23
08/23
ReMEDy2, NCT05065216: Treatment of Acute Ischemic Stroke ( Trial)

Recruiting
2/3
728
US
Recombinant human tissue kallikrein, DM199, Placebo for DM199 Solution for Injection
DiaMedica Therapeutics Inc
Acute Stroke, Ischemic Stroke, Stroke
12/26
12/26
OSC-VTE-003, NCT05389488: OsciPulse D-dimer Efficacy Trial

Withdrawn
2
40
US
OsciPulse system, Flowtron ACS900
OsciFlex LLC, University of Pennsylvania
Venous Thromboses, Ischemic Stroke
12/22
03/23
DOMINO, NCT03023449: Diffuse Optical Monitoring with Inhaled Nitric Oxide

Active, not recruiting
2
40
US
Nitric Oxide, iNO, NO2
Steven Messe, Mallinckrodt
Stroke
07/25
07/25
NCT06477016: OsciPulse D-dimer Pilot Trial

Not yet recruiting
N/A
40
US
OsciPulse, Intermittent Pneumatic Compression
University of Pennsylvania, OsciFlex LLC
Ischemic Stroke
11/25
11/25
CHaMP, NCT05155956: Cerebral Hemodynamics and Microemboli During Placement of Relay®Branch Thoracic Stent-Graft System

Active, not recruiting
N/A
20
US
transcranial Doppler ultrasonography (TCD)
University of Pennsylvania, Bolton Medical
Thoracic Aortic Aneurysm, Thoracic Aortic Dissection, Microemboli
12/24
12/25
Sleep SMART, NCT03812653: Sleep for Stroke Management and Recovery Trial

Recruiting
N/A
3062
US
CPAP
University of Michigan, National Institute of Neurological Disorders and Stroke (NINDS), FusionHealth LLC, Medical University of South Carolina, University of Cincinnati
Ischemic Stroke, Sleep Apnea, Sleep Apnea, Obstructive, Stroke, CPAP, Telemedicine, Home Sleep Apnea Test, Randomized Clinical Trial, Multicenter Trial
11/26
11/26
Loren, Alison W
ACCESS, NCT04904588: HLA-Mismatched Unrelated Donor Hematopoietic Cell Transplantation With Post-Transplantation Cyclophosphamide

Recruiting
2
300
US
Busulfan, Busulfex®, Fludarabine, Fludara®, Total-body irradiation, TBI, Cyclophosphamide, Cytoxan®, Melphalan, PBSC Hematopoietic Stem Cell Transplantation (HSCT), PBSC HSCT, PBSC HCT, PBSC Transplantation, Bone Marrow Hematopoietic Stem Cell Transplantation, BM HSCT, BM HCT, Bone Marrow Transplantation, Post-transplant Cyclophosphamide, Mesna, Mesnex®, Tacrolimus, Mycophenolate Mofetil, MMF, Cellcept®, Patient-Reported Outcomes
Center for International Blood and Marrow Transplant Research, National Marrow Donor Program
Acute Lymphoblastic Leukemia, Acute Myelogenous Leukemia, Mixed Phenotype Acute Leukemia, Acute Leukemia, Myelodysplastic Syndromes, Chronic Myelogenous Leukemia, Chronic Lymphocytic Leukemia, Lymphoma
07/24
07/24
Shaw, Mary
NCT06481631: Patient-clinical Linkages to Improve Trust and Engagement in Postpartum Healthcare

Not yet recruiting
N/A
250
NA
The PEN-3 Intervention Model
Jackson State University, Mississippi State Department of Health, University of Mississippi Medical Center, Harvard School of Public Health (HSPH)
Family Dynamics, Trust in Healthcare System, Family Structure, Health Literacy, Contraception, Maternal Behavior, Postpartum Mood Disturbance
06/29
06/30
George, Michael
COVER, NCT05080218: COVID-19 VaccinE Response in Rheumatology Patients

Recruiting
4
1000
US
Upadacitinib, Rinvoq, Abatacept, Orencia SQ, Secukinumab, Cosentyx, Tofacitinib, Xeljanz, TNF Inhibitor, Etanercept, Certolizumab, Golimumab SQ, Adalimumab, Canakinumab Injection, Ilaris, Baricitinib, Olumiant, Ixekizumab, Taltz
Jeffrey Curtis, University of Alabama at Birmingham, University of Nebraska, University of Pennsylvania, AbbVie, Bristol-Myers Squibb, Novartis, Eli Lilly and Company, Pfizer, Illumination Health
Rheumatoid Arthritis, Psoriatic Arthritis, Spondylarthritis
02/24
09/24
MINT, NCT05799755: Myositis Interstitial Lung Disease Nintedanib Trial

Active, not recruiting
4
70
US
Nintedanib, OFEV, Placebo, Standard of Care
Rohit Aggarwal, MD, Boehringer Ingelheim
Myositis Associated Interstitial Lund Disease (MA-ILD)
07/25
12/25
NCT04662359: Ultrasound Efficacy in Moderate Rheumatoid Arthritis

Completed
N/A
18
US
Ultrasound Assessment
University of Pennsylvania
Rheumatoid Arthritis
11/22
12/22
Baker, Joshua
RESET-RA, NCT04539964: Vagus Nerve Stimulation for Moderate to Severe Rheumatoid Arthritis

Active, not recruiting
3
243
US
Implant Procedure, Surgical placement of vagus nerve stimulator inside the neck, Conventional Synthetic DMARD, Background therapy with conventional synthetic DMARD, Active stimulation, Non-active stimulation
SetPoint Medical Corporation
Rheumatoid Arthritis
05/24
10/27
MOVE-OK, NCT05035810: A Pragmatic Trial to Determine the Benefit of Behaviorally Enhanced Exercise Incentives and Corticosteroid Injections in Osteoarthritis of the Knee Marching On for Veterans With Osteoarthritis of the Knee

Active, not recruiting
3
221
US
Social Incentives and Gamification to Promote Exercise, Corticosteroid Injection given in A-B order, No Social Incentive applied, Procedure: Corticosteroid Injection given in B-A order
VA Office of Research and Development
Osteoarthritis of the Knee
11/24
12/25
ReAKTIV, NCT06488144: Rehabilitation for Arthritis of The Knee: mainTaining Improvement for Veterans

Not yet recruiting
3
254
US
Health coach, Remote Incentive Program
VA Office of Research and Development
Osteoarthritis, Knee
03/29
06/29
STAAR, NCT04046224 / 2019-000667-24: Dose-Ranging Study of ST-920, an AAV2/6 Human Alpha Galactosidase A Gene Therapy in Subjects With Fabry Disease

Active, not recruiting
1/2
34
Europe, Canada, US, RoW
ST-920
Sangamo Therapeutics
Fabry Disease
04/25
09/25
OBS18020, NCT06192576: A Real-world Long-term Safety and Immunogenicity Study of Olipudase Alfa Therapy in Pediatric Patients Less Than 2 Years of Age With Acid Sphingomyelinase Deficiency (ASMD)

Recruiting
N/A
10
US
Olipudase alfa, Xenpozyme®
Sanofi, Pulse Infoframe Ltd.
Niemann-Pick Diseases, Acid Sphingomyelinase Deficiency
01/29
01/29
RAiSeD, NCT05530694: Rheumatoid Arthritis Shared Decision Making

Recruiting
N/A
792
US
Clinician communication training, fostering choice awareness, Patient activation, AskShareKnow, RA Medication summary guide and RA Choice
VA Office of Research and Development
Rheumatoid Arthritis
09/25
03/26
NCT05040178: An Observational Study of Carbaglu® for the Treatment of MMA and PA in Adults and Pediatrics

Recruiting
N/A
20
US
Carglumic Acid, Carbaglu®
Recordati Rare Diseases, Target PharmaSolutions, Inc.
Hyperammonemia, Methylmalonic Acidemia, Propionic Acidemia
06/32
06/32
Gnap, Mary
TAP-CHF, NCT04160000: Treatment Of Atrial Fibrillation In Preserved Cardiac Function Heart Failure

Recruiting
4
360
Europe, US
Catheter ablation, Ablation, Rate or Rhythm control antiarrhythmic drugs for atrial fibrillation, Antiarrhythmic Drug, Insertion of CardioMems Hemodynamic monitor, IPM, Empiric heart failure drug therapy, HFDrug
Electrophysiology Research Foundation
Atrial Fibrillation, Heart Failure, Diastolic Heart Failure
12/24
06/25
PSOT, NCT03481413: Patient Specific Optimized Therapy Post-Market Clinical Follow-up Study

Terminated
N/A
566
Europe, US, RoW
Ablation
EPD Solutions, A Philips Company
Arrythmia
03/23
03/23
ADVENT LTO, NCT06526546: ADVENT Trial Long Term Outcomes Evaluating Atrial Fibrillation Progression Study

Enrolling by invitation
N/A
583
US
Boston Scientific Corporation
Paroxysmal Atrial Fibrillation
07/25
10/25
NCT05337241: Saline Enhanced Radiofrequency (SERF) Needle Ablation for Refractory VT

Not yet recruiting
N/A
130
Canada, US
Saline Enhanced Radiofrequency (SERF) Ablation, Intramural Needle Ablation
Thermedical, Inc.
Refractory Ventricular Tachycardia
06/27
06/27
TRAP-AF, NCT05185310: Strategies in Patients Undergoing Repeat AF Ablation

Terminated
N/A
8
US
Ablation
University of Pennsylvania
Atrial Fibrillation
02/23
02/23
DEFINE AFib, NCT04926857: (Atrial Fibrillation)

Completed
N/A
973
US
Non-Interventional
Medtronic Cardiac Rhythm and Heart Failure
Atrial Fibrillation
01/24
01/24
Kreider, Mary
TETON, NCT04708782: Study of Efficacy and Safety of Inhaled Treprostinil in Subjects With Idiopathic Pulmonary Fibrosis

Hourglass May 2024 - Aug 2024 : Topline data for IPF
Hourglass Jan 2023 - Mar 2023 : Enrollment completion of TETON trial for IPF
Recruiting
3
576
Canada, US
Placebo, Inhaled Treprostinil, Tyvaso, Treprostinil Ultrasonic Nebulizer
United Therapeutics
Idiopathic Pulmonary Fibrosis, Interstitial Lung Disease
06/25
06/25
Morley, Andrea
APPLE, NCT06408181: Aspirin to Prevent Pregnancy Loss and Preeclampsia

Recruiting
3
1150
US
Aspirin 162 mg, acetylsalicylic acid, ASA, Aspirin 81mg
University of Pennsylvania, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Pre-Eclampsia, Pregnancy Loss
06/29
06/29
NatPro, NCT04551807: Natural Versus Programmed Frozen Embryo Transfer

Active, not recruiting
3
788
US
Modified natural cycle, Programmed cycle
JHSPH Center for Clinical Trials
Pregnancy Related, Pre-Eclampsia
04/25
08/25
INSUPP-PCOS, NCT03864068: Inositol Supplementation to Treat PCOS

Recruiting
2
128
US
Placebo, maltodextrin and inulin, Inositol
Milton S. Hershey Medical Center, National Center for Complementary and Integrative Health (NCCIH)
Polycystic Ovary Syndrome, Anovulation, Hyperandrogenism, Insulin Resistance, Glucose Intolerance, Metabolic Complication
11/25
11/25
EMPOWER, NCT04598698: The Study: Endometriosis Diagnosis Using MicroRNA

Active, not recruiting
N/A
750
NA
Dot Laboratories, Inc.
Endometriosis
05/23
12/24
NCT06206746: The REBALANCE Study - a Prospective, Multicenter, Randomized, Pivotal Study of the May Health System

Recruiting
N/A
195
US
May Health System
May Health
Polycystic Ovary Syndrome, Infertility, Female
05/25
05/28
Thiele, Elizabeth
NCT03790137: Treatment of Sunflower Syndrome With ZX008 (Fenfluramine Hydrochloride) in Children and Young Adults (Ages 4-25).

Completed
3
20
US
Fenfluramine Hydrochloride, ZX008
Elizabeth Anne Thiele, Zogenix International Limited, Inc., a subsidiary of Zogenix, Inc.
Photosensitive Epilepsy
11/21
07/24
NCT05067634 / 2020-005344-27: Safety and Efficacy Study of Cenobamate in Pediatric Subjects 2-17 Years of Age with Partial-onset (focal) Seizures

Recruiting
3
140
Europe, US, RoW
Xcopri
SK Life Science, Inc.
Partial Epilepsy
05/26
07/26
NCT05076838: Pharmacokinetics Study of VALTOCO® in Pediatric Subjects With Epilepsy

Active, not recruiting
1/2
30
US
Diazepam Nasal Spray [Valtoco]
Neurelis, Inc.
Epilepsy
08/23
10/24
NCT06387186: Leucine Enriched Essential Amino Acid Powder as an Add-on to a Classic Ketogenic Diet in Refractory Epilepsy

Not yet recruiting
1
15
US
Leucine-Enriched Essential Amino Acid powder, LEAA
Elizabeth Anne Thiele, Ajinomoto USA, INC., Ajinomoto Co., Inc.
Refractory Epilepsy, Drug Resistant Epilepsy
03/25
03/25
NCT05676099: TSC Biosample Repository and Natural History Database

Recruiting
N/A
5000
Canada, US
Phlebotomy, Buccal (cheek) swab, Genetic Testing, Tissue donation after routine clinical procedure
National Tuberous Sclerosis Association
Tuberous Sclerosis, Lymphangioleiomyomatosis
12/50
12/50
Alston, Gabrielle
NCT05139121: Study of the Safety and Efficacy of MR-100A-01 in Approximately 1200 Healthy Women for up to 13 Cycles

Completed
3
1319
Canada, US
MR-100A-01, Transdermal contraceptive delivery system
Mylan Technologies Inc., Mylan Inc.
Contraception
01/25
01/25
Chen, Isaac
RESET-RA, NCT04539964: Vagus Nerve Stimulation for Moderate to Severe Rheumatoid Arthritis

Active, not recruiting
3
243
US
Implant Procedure, Surgical placement of vagus nerve stimulator inside the neck, Conventional Synthetic DMARD, Background therapy with conventional synthetic DMARD, Active stimulation, Non-active stimulation
SetPoint Medical Corporation
Rheumatoid Arthritis
05/24
10/27
Bonilla, Juliana
RESET-RA, NCT04539964: Vagus Nerve Stimulation for Moderate to Severe Rheumatoid Arthritis

Active, not recruiting
3
243
US
Implant Procedure, Surgical placement of vagus nerve stimulator inside the neck, Conventional Synthetic DMARD, Background therapy with conventional synthetic DMARD, Active stimulation, Non-active stimulation
SetPoint Medical Corporation
Rheumatoid Arthritis
05/24
10/27
Ellis, Sarah
RISE 2, NCT06132893: A Study to Determine if BHV-7000 is Effective and Safe in Adults With Refractory Focal Onset Epilepsy

Recruiting
2/3
390
Europe, US, RoW
BHV-7000, Placebo
Biohaven Therapeutics Ltd.
Focal Epilepsy
08/25
09/25
NCT05676099: TSC Biosample Repository and Natural History Database

Recruiting
N/A
5000
Canada, US
Phlebotomy, Buccal (cheek) swab, Genetic Testing, Tissue donation after routine clinical procedure
National Tuberous Sclerosis Association
Tuberous Sclerosis, Lymphangioleiomyomatosis
12/50
12/50

Download Options