University of Wisconsin Madison
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 29 Trials 
74 Trials

   

 
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Salamat, Shahriar
WBDP, NCT00585572: Wisconsin Brain Donor Program

Enrolling by invitation
N/A
9999
US
University of Wisconsin, Madison, University of Washington, National Institute on Aging (NIA)
Alzheimer's Disease, Mild Cognitive Impairment
08/50
08/50
Foley, David
NCT05917522: Assessment of Biomarker-Guided CNI Substitution In Kidney Transplantation

Recruiting
2
800
US
Abatacept, Orencia, Standard of Care at US Transplant Centers
National Institute of Allergy and Infectious Diseases (NIAID)
Kidney Transplant
07/27
07/29
NCT05045794: Bridge to HOPE: Hypothermic Oxygenated Perfusion Versus Cold Storage Prior to Liver Transplantation

Completed
N/A
219
US
VitaSmart Liver Machine Perfusion System, VitaSmart Liver Machine, Hypothermic oxygenated perfusion, Static cold storage
Bridge to Life Ltd.
End Stage Liver DIsease, Liver Failure
06/24
06/24
Raval, Amish N
NCT02438306: CardiAMP™ Cell Therapy for Heart Failure Trial

Active, not recruiting
3
125
Canada, US
Autologous cell therapy, Sham
BioCardia, Inc.
Heart Failure, Systolic
12/24
12/26
CardiAMP CMI, NCT03455725: CardiAMP Cell Therapy Chronic Myocardial Ischemia Trial

Recruiting
N/A
343
US
CardiAMP Cell Therapy System, Sham Treatment
BioCardia, Inc.
Refractory Angina, Chronic Myocardial Ischemia
07/25
12/26
COSIRA-II, NCT05102019: Efficacy of the COronary SInus Reducer in Patients with Refractory Angina II

Recruiting
N/A
380
Canada, US
Arm 1: treatment with Neovasc Reducer, Arm 2 (control): Implantation procedure with no device implanted, Arm 3 (unblinded, non-randomized): Single arm registry
Neovasc Inc., Shockwave Medical, Inc.
Refractory Angina
06/25
12/28
NCT06258447: CardiAMP Heart Failure II Trial for Patients With Ischemic Heart Failure With Reduced Ejection Fraction

Recruiting
N/A
250
US
Autologous bone marrow mononuclear cells processed / delivered using the CardiAMP cell therapy system
BioCardia, Inc.
Ischemic Heart Failure
04/27
04/29
Rao, Venkat K
NCT03187080: Enhanced Recovery Strategies in Elective Breast Surgery

Terminated
4
113
US
Paravertebral block procedure using either local anesthetic (0.25% bupivacaine) or sterile saline, Enhanced recovery after breast surgery (ERABS) strategies, Sham paravertebral block using saline, Paravertebral block using local anesthetic
University of Wisconsin, Madison
Pain, Acute, Nausea, Vomiting, Postoperative, Opioid Use, Satisfaction
06/21
06/21
Anderson, R Rox
NCT04730583: Tolerability of Device Based Therapies for Neurofibromatosis Type 1 Cutaneous Neurofibromas

Active, not recruiting
1
20
US
Kybella, 1064nm laser, 755nm Alexandrite Laser
Massachusetts General Hospital, Johns Hopkins University
Cutaneous Neurofibroma
12/24
12/24
CardiAMP CMI, NCT03455725: CardiAMP Cell Therapy Chronic Myocardial Ischemia Trial

Recruiting
N/A
343
US
CardiAMP Cell Therapy System, Sham Treatment
BioCardia, Inc.
Refractory Angina, Chronic Myocardial Ischemia
07/25
12/26
NCT01873131: A Clinical Trial of Pulsed-dye Laser Versus Timolol Topical Solution Versus Observation on the Growth of Hemangioma in Newborn

Recruiting
N/A
126
US
topical timolol maleate, timolol, beta blocker, Pulsed dye laser, PDL
Massachusetts General Hospital
Hemangioma
12/25
12/28
NCT05149755: Evolut™ EXPAND TAVR II Pivotal Trial

Recruiting
N/A
650
Europe, Canada, Japan, US, RoW
Medtronic Evolut PRO+ TAVR System, or Evolut FX TAVR System, and guideline-directed management and therapy (GDMT)
Medtronic Cardiovascular
Moderate Aortic Valve Stenosis
02/26
12/34
PROTECT IV, NCT04763200: Impella®-Supported PCI in High-Risk Patients With Complex Coronary Artery Disease and Reduced Left Ventricular Function

Recruiting
N/A
1252
Europe, Canada, US
Impella CP® / Impella CP® with SmartAssist® / Impella 2.5®, IABP Intra-aortic balloon pump
Abiomed Inc.
Left Ventricular Dysfunction, Coronary Artery Disease
03/26
10/27
Fain, Sean
NCT04855305: Optimizing and Standardizing 129Xe Gas Exchange MRI to Visualize Regional Therapy Response in Interstitial Lung Disease

Recruiting
2
147
US
Hyperpolarized 129Xe
Bastiaan Driehuys, National Heart, Lung, and Blood Institute (NHLBI), Children's Hospital Medical Center, Cincinnati, University of Cincinnati, University of Iowa
Interstitial Lung Diseases
03/25
03/25
NCT06191640: Sinus Disease in Young Children With Cystic Fibrosis

Recruiting
N/A
80
US
Ivacaftor or elexacaftor/tezacaftor/ivacaftor, Kalydeco or Trikafta; Vertex (VX)-770 or VX-445/VX-661/VX-770
University of California, Los Angeles, University of Kansas Medical Center, Children's Hospital Medical Center, Cincinnati, University of Iowa, University of Virginia, Children's Hospital Colorado, University of Vermont
Cystic Fibrosis in Children, Cystic Fibrosis, Chronic Rhinosinusitis (Diagnosis), Olfactory Disorder, Olfactory Impairment
04/26
04/26
NCT06406777: Chronic Lung Allograft Dysfunction MRI Study

Not yet recruiting
N/A
100
NA
Spirometry, Contrast Lung Computed Tomography (CT) Scan, Oxygen enhanced magnetic resonance imaging (OE-MRI) Scan, 129Xe MRI scans
Sean Fain
Chronic Lung Allograft Dysfunction Lung MRI (CLAD)
09/28
09/28
Rosenkranz, Melissa
MAIA-SC, NCT06299592: Comparison of Microglial Activation in Severe Asthma and Healthy Controls

Recruiting
N/A
100
US
PET/MRI using [18F]FEPPA tracer
University of Wisconsin, Madison, National Institute on Aging (NIA)
Asthma
08/28
08/28
MAIA, NCT04307667: Microglia Activation in Asthma

Recruiting
N/A
50
US
Whole lung antigen challenge (WLAC), [18F]FEPPA
University of Wisconsin, Madison, National Institute on Aging (NIA), National Heart, Lung, and Blood Institute (NHLBI)
Asthma
08/28
08/28
Rao, T H
REMODEL-1, NCT05147220 / 2020-005899-36: Efficacy and Safety of Remibrutinib Compared to Teriflunomide in Participants With Relapsing Multiple Sclerosis (RMS)

Recruiting
3
800
Europe, US, RoW
Remibrutinib, LOU064, Teriflunomide
Novartis Pharmaceuticals, Novartis Pharma AG
Relapsing Multiple Sclerosis
04/26
10/30
ALITHIOS, NCT03650114 / 2017-004703-51: Long-term Safety, Tolerability and Effectiveness Study of Ofatumumab in Patients With Relapsing MS

Calendar Jan 2028 - Dec 2028: Data from ALITHIOS trial for multiple sclerosis
Recruiting
3
2060
Europe, Canada, Japan, US, RoW
Ofatumumab, Tetanus toxoid (TT) containing vaccine (Td, Tdap), 13-valent pneumococcal conjugate vaccine (13-PCV), 23-valent pneumococcal polysaccharide vaccine (23-PPV), Seasonal Quadrivalent influenza vaccine, Keyhole limpet hemocyanin (KLH) neo-antigen
Novartis Pharmaceuticals
Relapsing Multiple Sclerosis
12/27
09/28
Leist, Thomas
REMODEL-1, NCT05147220 / 2020-005899-36: Efficacy and Safety of Remibrutinib Compared to Teriflunomide in Participants With Relapsing Multiple Sclerosis (RMS)

Recruiting
3
800
Europe, US, RoW
Remibrutinib, LOU064, Teriflunomide
Novartis Pharmaceuticals, Novartis Pharma AG
Relapsing Multiple Sclerosis
04/26
10/30
ALITHIOS, NCT03650114 / 2017-004703-51: Long-term Safety, Tolerability and Effectiveness Study of Ofatumumab in Patients With Relapsing MS

Calendar Jan 2028 - Dec 2028: Data from ALITHIOS trial for multiple sclerosis
Recruiting
3
2060
Europe, Canada, Japan, US, RoW
Ofatumumab, Tetanus toxoid (TT) containing vaccine (Td, Tdap), 13-valent pneumococcal conjugate vaccine (13-PCV), 23-valent pneumococcal polysaccharide vaccine (23-PPV), Seasonal Quadrivalent influenza vaccine, Keyhole limpet hemocyanin (KLH) neo-antigen
Novartis Pharmaceuticals
Relapsing Multiple Sclerosis
12/27
09/28
MoveS-it, NCT04602390: Assessment of ANK-700 in Patients With Relapsing Remitting Multiple Sclerosis

Completed
1
33
US
ANK-700, Placebo
Anokion SA
Multiple Sclerosis (MS), Relapsing Remitting Multiple Sclerosis
04/24
04/24
Binkley, Neil
NCT04167163: Abaloparatide Before Total Knee Arthroplasty

Active, not recruiting
4
58
US
Abaloparatide, Tymlos
University of Wisconsin, Madison, Radius Health, Inc.
Osteoporosis, Arthroplasties, Knee Replacement
03/25
03/25
Denlinger, Loren
GRAIL^3, NCT04706507: Ganciclovir to Prevent Reactivation of Cytomegalovirus in Patients With Acute Respiratory Failure and Sepsis

Active, not recruiting
3
500
US
IV Ganciclovir, Cytovene
Fred Hutchinson Cancer Center, National Heart, Lung, and Blood Institute (NHLBI)
Acute Respiratory Failure
10/24
08/27
NCT04129931: PrecISE (Precision Interventions for Severe and/or Exacerbation-Prone Asthma) Network Study

Active, not recruiting
2
395
US
MCT, Breathe Better Diet (BBD), Clazakizumab, Anti-interleukin 6 monoclonal antibody, Anti-IL-6 mAb, BMS-945429, ALD518, Broncho-Vaxom, OM-85 BV VEGETAL, Imatinib Mesylate, Gleevec, Zoleta, Glivec, Ziatir, Cavosonstat, N91115, Placebo
University of North Carolina, Chapel Hill, National Heart, Lung, and Blood Institute (NHLBI)
Asthma
12/24
12/24
NCT04543461: American Lung Association (ALA) Lung Health Cohort

Recruiting
N/A
4000
US
Johns Hopkins University, National Heart, Lung, and Blood Institute (NHLBI), American Lung Association, Stanford University
Lung Diseases
09/26
09/26
NCT01606826: Severe Asthma Research Program

Active, not recruiting
N/A
1100
US
Milton S. Hershey Medical Center, National Heart, Lung, and Blood Institute (NHLBI)
Asthma
06/26
12/26
Tyrlikova, Ivana
REMODEL-1, NCT05147220 / 2020-005899-36: Efficacy and Safety of Remibrutinib Compared to Teriflunomide in Participants With Relapsing Multiple Sclerosis (RMS)

Recruiting
3
800
Europe, US, RoW
Remibrutinib, LOU064, Teriflunomide
Novartis Pharmaceuticals, Novartis Pharma AG
Relapsing Multiple Sclerosis
04/26
10/30
NCT05517954: Cortical Excitability in Post-traumatic Epilepsy

Recruiting
N/A
30
US
Mid-Atlantic Epilepsy and Sleep Center, LLC, Alexander Rotenberg, M.D., Ph.D
Traumatic Brain Injury, Cortical Excitability, Epilepsy
08/23
08/24
Grant, Kaelin M
PACES, NCT04045665 / 2021-005022-18: Anticoagulation for New-Onset Post-Operative Atrial Fibrillation After CABG

Recruiting
3
3200
Europe, Canada, US
Antiplatelet-only strategy, Oral Anticoagulant plus background antiplatelet therapy
Icahn School of Medicine at Mount Sinai, National Heart, Lung, and Blood Institute (NHLBI), Vanderbilt University Medical Center
Atrial Fibrillation, Stroke, Bleeding
06/25
06/25
CPAT-ISR, NCT05077254: COVID Protection After Transplant-Immunosuppression Reduction

Active, not recruiting
2
400
US
Pfizer-BioNTech COVID-19 Vaccine 2023-2024, mRNA COVID-19 vaccine, BNT162b2 mRNA COVID-19 vaccine, SARS-CoV-2 RNA vaccine, Comirnaty, Moderna COVID-19 Vaccine 2023-2024, Moderna COVID-19 vaccine, SARS-CoV-2 vaccine, Spikevax, SOC IS Regimen, Standard of Care transplant immunosuppression regimen, Immunosuppression (IS), mycophenolate mofetil (MMF) or equivalent, tacrolimus, SOC IS Reduction, Standard of Care (SOC) transplant immunosuppression regimen, Immunosuppression (IS) Reduction
National Institute of Allergy and Infectious Diseases (NIAID), PPD, Johns Hopkins University
Kidney Transplant Recipients, Liver Transplant Recipients
02/24
03/25
STAR-T, NCT04976530: Safe and Timely Antithrombotic Removal - Ticagrelor

Completed
N/A
140
Canada, US
DrugSorb-ATR system, Sorbent hemoperfusion system, Sham comparator
CytoSorbents, Inc
Hemorrhage, Surgical, Blood Loss, Surgical, Blood Loss, Postoperative, Hemorrhage Postoperative
08/23
08/23
Klaus, Danika
PROTECT, NCT05476497: Phase I Trial to Evaluate VLP Peanut in Healthy and Peanut Allergic Subjects

Recruiting
1
46
US
VLP Peanut, Placebo
Allergy Therapeutics
Peanut Allergy
10/25
10/25
NCT04543461: American Lung Association (ALA) Lung Health Cohort

Recruiting
N/A
4000
US
Johns Hopkins University, National Heart, Lung, and Blood Institute (NHLBI), American Lung Association, Stanford University
Lung Diseases
09/26
09/26
Janko, Kimberly
DELIVER-MS, NCT03535298: Determining the Effectiveness of earLy Intensive Versus Escalation Approaches for RRMS

Active, not recruiting
4
800
Europe, US
Early Highly Effective Therapies Group, Lemtrada (alemtuzumab), Ocrevus (ocrelizumab), Tysabri (natalizumab), Rituxan (rituximab), Kesimpta (ofatumumab), Briumvi (ublituximab), Escalation Therapies Group, Betaseron (beta interferon), Copaxone (glatiramer acetate), Aubagio (teriflunomide), Extavia (beta interferon), Gilenya (fingolimod), Glatopa (glatiramer acetate), Plegridy (beta interferon), Rebif (beta interferon), Tecfidera (dimethyl fumarate), Avonex (beta interferon), Mavenclad (cladribine), Mayzent (siponimod), Vumerity (diroximel fumarate), Zeposia (ozanimod), Bafiertam (monomethyl fumarate), Ponvory (ponesimod)
The Cleveland Clinic, University of Nottingham
Multiple Sclerosis, Relapsing-Remitting
07/27
09/30
NCT06069934: Pridopidine in Amyotrophic Lateral Sclerosis (EAP 2)

No Longer Available
N/A
US
Pridopidine
Prilenia, Massachusetts General Hospital, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH)
Amyotrophic Lateral Sclerosis
 
 
Budge, Stephanie
NCT05140174: Psychotherapy Interventions to Support Transgender, Two-Spirit, and Nonbinary People of Color

Completed
N/A
51
US
Radical Healing and Internalized Stigma (RHIS) Training
University of Wisconsin, Madison
Mental Health
08/23
08/23
NCT05884307: Trans Care: An Online Intervention to Reduce Symptoms of Gender Dysphoria

Completed
N/A
138
US
Trans Care Web App
University of Wisconsin, Madison
Gender Dysphoria
08/24
08/24
NCT05903911: Trans Care: An Online Intervention to Reduce Symptoms of Gender Dysphoria

Recruiting
N/A
260
US
Trans Care Web App
University of Wisconsin, Madison
Gender Dysphoria
05/25
05/25
Ark, Cassondra Vander
NCT02438306: CardiAMP™ Cell Therapy for Heart Failure Trial

Active, not recruiting
3
125
Canada, US
Autologous cell therapy, Sham
BioCardia, Inc.
Heart Failure, Systolic
12/24
12/26
CardiAMP CMI, NCT03455725: CardiAMP Cell Therapy Chronic Myocardial Ischemia Trial

Recruiting
N/A
343
US
CardiAMP Cell Therapy System, Sham Treatment
BioCardia, Inc.
Refractory Angina, Chronic Myocardial Ischemia
07/25
12/26
Hartenbach, Ellen M
UP-NEXT, NCT05329545: Upifitamab Rilsodotin Maintenance in Platinum-Sensitive Recurrent Ovarian Cancer

Terminated
3
20
Canada, US, RoW
Upifitimab rilsodotin, XMT-1536 Antibody Drug Conjugate, Placebo
Mersana Therapeutics, GOG Foundation, European Network of Gynaecological Oncological Trial Groups (ENGOT)
High Grade Serous Ovarian Cancer, Fallopian Tube Cancer, Primary Peritoneal Cancer
09/23
09/23
NCT02584478 / 2021-003871-32: Phase 1/2a/3 Evaluation of Adding AL3818 to Standard Platinum-Based Chemotherapy in Subjects With Recurrent or Metastatic Endometrial, Ovarian, Fallopian, Primary Peritoneal or Cervical Carcinoma (AL3818-US-002)

Active, not recruiting
3
294
Europe, US, RoW
AL3818, Anlotinib Hydrochloride, Anlotinib, Catequentinib, Paclitaxel, Pegylated Liposomal Doxorubicin (PLD), Topotecan, Daily Topotecan, Weekly Topotecan, Carboplatin, Paraplatin, Taxol
Advenchen Laboratories, LLC, Advenchen Laboratories, LLC
Endometrial Carcinoma, Ovarian Carcinoma, Fallopian Tube Carcinoma, Primary Peritoneal Carcinoma, Cervical Carcinoma
10/24
12/24
ENGOT-EN20, NCT05611931 / 2022-002540-42: Selinexor in Maintenance Therapy After Systemic Therapy for Participants with P53 Wild-Type, Advanced or Recurrent Endometrial Carcinoma

Jul 2024 - Dec 2024: Top-line data from XPORT-EC trial in participants with TP53 wild type endometrial cancer
Recruiting
3
220
Europe, Canada, US, RoW
Selinexor, KPT-330, Matching Placebo for selinexor
Karyopharm Therapeutics Inc, GOG Foundation, European Network of Gynaecological Oncological Trial Groups (ENGOT), Belgium and Luxembourg Gynaecological Oncology Group, North Eastern German Society of Gynaecological Oncology, Multicentre Italian Trials in Ovarian Cancer and Gynecologic Malignancies, Spanish Research Group in Ovarian Cancer, The Central and Eastern European Gynecologic Oncology Group, Israeli Society of Gynecologic Oncology, Australia New Zealand Gynaecological Oncology Group
Endometrial Cancer
01/25
01/28
FLORA-4, NCT04498117 / 2020-002270-26: Oregovomab Plus Chemo in Newly Diagnosed Patients With Advanced Epithelial Ovarian Cancer Following Optimal Debulking Surgery

Active, not recruiting
3
615
Europe, Canada, US, RoW
Oregovomab, MAb-B43.13, Paclitaxel, Taxol, Carboplatin, Paraplatin, Placebo
CanariaBio Inc., Gynecologic Oncology Group, Iqvia Pty Ltd
Carcinoma, Ovarian Epithelial, Ovarian Neoplasms, Ovarian Cancer, Ovarian Serous Adenocarcinoma, Fallopian Tube Neoplasms, Fallopian Tube Adenocarcinoma, Fallopian Tube Serous Adenocarcinoma, Peritoneal Cancer, Peritoneal Carcinoma, Peritoneal Neoplasms
09/25
08/27
NRG-GY026, NCT05256225: Testing the Addition of Trastuzumab or Trastuzumab/Pertuzumab to the Usual Chemotherapy for HER2 Positive Endometrial Cancer

Recruiting
2/3
525
US
Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Carboplatin, Blastocarb, Carboplat, Carboplatin Hexal, Carboplatino, Carboplatinum, Carbosin, Carbosol, Carbotec, CBDCA, Displata, Ercar, JM-8, JM8, Nealorin, Novoplatinum, Paraplatin, Paraplatin AQ, Paraplatine, Platinwas, Ribocarbo, Computed Tomography, CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, Computerized Tomography (CT) scan, CT, CT Scan, tomography, Echocardiography, EC, High-Dose-Rate Vaginal Cuff Brachytherapy, HDR-VCB, Hyaluronidase-zzxf/Pertuzumab/Trastuzumab, Pertuzumab and Trastuzumab hyaluronidase, Pertuzumab, Trastuzumab, and Hyaluronidase-zzxf, Pertuzumab/Trastuzumab/Hyaluronidase-zzxf, Phesgo, Multigated Acquisition Scan, Blood Pool Scan, Equilibrium Radionuclide Angiography, Gated Blood Pool Imaging, MUGA, Radionuclide Ventriculography, RNVG, SYMA Scanning, Synchronized Multigated Acquisition Scanning, Paclitaxel, Anzatax, Asotax, Bristaxol, Praxel, Taxol, Taxol Konzentrat, Quality-of-Life Assessment, Quality of Life Assessment, Trastuzumab/Hyaluronidase-oysk, Herceptin Hylecta, Trastuzumab and Hyaluronidase, Trastuzumab and Hyaluronidase-oysk, Trastuzumab and Recombinant Human Hyaluronidase PH20, Trastuzumab and rHuPH20, Trastuzumab-Hyaluronidase-oysk
National Cancer Institute (NCI), NRG Oncology
Endometrial Carcinoma, Endometrial Clear Cell Adenocarcinoma, Endometrial Dedifferentiated Carcinoma, Endometrial Endometrioid Adenocarcinoma, Endometrial Mixed Cell Adenocarcinoma, Endometrial Serous Adenocarcinoma, Endometrial Undifferentiated Carcinoma, Uterine Corpus Carcinosarcoma
10/27
10/27
Dozor, Allen
NCT04543461: American Lung Association (ALA) Lung Health Cohort

Recruiting
N/A
4000
US
Johns Hopkins University, National Heart, Lung, and Blood Institute (NHLBI), American Lung Association, Stanford University
Lung Diseases
09/26
09/26
NCT05639556: Strength and Muscle Related Outcomes for Nutrition and Lung Function in CF

Recruiting
N/A
300
US
BMI and lean mass index from DXA, Anthropometric Measurements, Hand-grip strength, Six-minute walk Test, Sit-to-Stand Test, Short physical performance battery (SPPB), BIA Sub-study, Accelerometry to assess physical activity, Gastrointestinal (GI) and nutrition questionnaires:, Psychosocial questionnaire: PHQ-8, Psychosocial questionnaire: GAD-7, Psychosocial questionnaire: The Treatment Self-Regulation Questionnaire (TSRQ), Psychosocial questionnaire: CF Fatalism Scale, Psychosocial questionnaire: Body Esteem Scale for Adolescents and Adults (BESAA), 12-month Questionnaire, Oral glucose tolerance testing (OGTT), Continuous glucose monitoring (CGM), Chest CT scans (When available within the past 6 months in medical records), Hologic Dual X-Ray Absorptiometry (DXA), Ultrasound Sub-study of assessment of appendage muscles using ultrasound, Psychosocial questionnaire: Hunger Vital Sign questionnaire, Respiratory symptom questionnaire: CRISS, Spirometry, Psychosocial questionnaire: Additional Health Questionnaire
Jaeb Center for Health Research
Cystic Fibrosis
12/28
12/28
Ganesh, Geeta A
REMODEL-1, NCT05147220 / 2020-005899-36: Efficacy and Safety of Remibrutinib Compared to Teriflunomide in Participants With Relapsing Multiple Sclerosis (RMS)

Recruiting
3
800
Europe, US, RoW
Remibrutinib, LOU064, Teriflunomide
Novartis Pharmaceuticals, Novartis Pharma AG
Relapsing Multiple Sclerosis
04/26
10/30
TREAT-MS, NCT03500328: Traditional Versus Early Aggressive Therapy for Multiple Sclerosis Trial

Recruiting
N/A
900
US
Natalizumab, Alemtuzumab, Ocrelizumab, Rituximab, Cladribine, Ofatumumab, Ublituximab-xiiy, Tysabri, Lemtrada, Ocrevus, Rituxan, Mavenclad, Kesimpta, Briumvi, Glatiramer acetate, Interferons (intramuscular, subcutaneous, pegylated) Teriflunomide, Fumarates (dimethyl, diroximel, monomethyl) Fingolimod, Siponimod, Ozanimod, Ponesimod, Copaxone, Glatopa, Avonex, Betaseron, Extavia, Rebif, Plegridy, Aubagio, Tecfidera, Vumerity, Bafiertam, Gilenya, Mayzent, Zeposia, Ponvory, Tascenso
Johns Hopkins University, Patient-Centered Outcomes Research Institute, National Multiple Sclerosis Society
Multiple Sclerosis, Relapsing-Remitting
08/25
08/25
VanWagner, Lisa
BLOCK LTR-HTN, NCT05275907: Mechanism of Hypertension Treatments in Liver Transplant Recipients

Withdrawn
4
15
US
Amlodipine Besylate, Chlorthalidone
Northwestern University, National Heart, Lung, and Blood Institute (NHLBI), American Society for Transplantation
High Blood Pressure, Liver Transplant, Renal Function Abnormal
10/23
10/23
ALTA TIPS, NCT03973372: A 5-year Longitudinal Observational Study of Patients Undergoing TIPS Placement

Recruiting
N/A
1000
US
University of Texas Southwestern Medical Center, University of California, San Francisco, Scripps Health, University of Wisconsin, Madison, University of Florida, University of Arizona, Stanford University, Columbia University, Weill Medical College of Cornell University, Baylor Scott and White Health, Mayo Clinic, University of Chicago, Digestive Health Foundation, W.L.Gore & Associates, University of Minnesota, Northwestern University
Cirrhosis, Liver, Transjugular Intrahepatic Portosystemic Shunt (TIPS)
07/25
12/27
Padilla, Cynthia
BLOCK LTR-HTN, NCT05275907: Mechanism of Hypertension Treatments in Liver Transplant Recipients

Withdrawn
4
15
US
Amlodipine Besylate, Chlorthalidone
Northwestern University, National Heart, Lung, and Blood Institute (NHLBI), American Society for Transplantation
High Blood Pressure, Liver Transplant, Renal Function Abnormal
10/23
10/23
ALTA TIPS, NCT03973372: A 5-year Longitudinal Observational Study of Patients Undergoing TIPS Placement

Recruiting
N/A
1000
US
University of Texas Southwestern Medical Center, University of California, San Francisco, Scripps Health, University of Wisconsin, Madison, University of Florida, University of Arizona, Stanford University, Columbia University, Weill Medical College of Cornell University, Baylor Scott and White Health, Mayo Clinic, University of Chicago, Digestive Health Foundation, W.L.Gore & Associates, University of Minnesota, Northwestern University
Cirrhosis, Liver, Transjugular Intrahepatic Portosystemic Shunt (TIPS)
07/25
12/27
FrAILT, NCT03228290: Functional Assessment in Liver Transplantation

Recruiting
N/A
5000
US
University of California, San Francisco, National Institute on Aging (NIA), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
End Stage Liver Disease
12/28
12/28
Stepien, Kimberly
NAC Attack, NCT05537220: Oral N-acetylcysteine for Retinitis Pigmentosa

Recruiting
3
438
Europe, Canada, US, RoW
N-acetylcysteine, Placebo
Johns Hopkins University, National Eye Institute (NEI), Duke University, Emory University, Massachusetts Eye and Ear Infirmary, Mayo Clinic, Medical College of Wisconsin, Retina Foundation of the Southwest, Stanford University, University of California, Davis, University of Florida, University of Iowa, University of Miami, University of Michigan, University of Minnesota, University of Oklahoma, University of Southern California, University of Utah, University of Washington, University of Wisconsin, Madison, Vanderbilt University, Vitreo Retinal Associates, PA, University of Houston, Medical University of Graz, McGill University, Universität Tübingen, Centro Medico ABC, Radboud University Medical Center, University of Amsterdam, University Hospital, Basel, Switzerland, University College London Hospitals, Northwestern University, University of Pennsylvania
Retinitis Pigmentosa
12/28
12/28
POLARIS, NCT06435000: An Observational Study in Subjects to Follow the Progression of Stargardt Disease Type 1 (STGD1) Caused by Bi-Allelic Autosomal Recessive Mutations in the ABCA4 Gene

Recruiting
N/A
75
Europe, US
Splice Bio
Stargardt, Stargardt's Disease, Stargardt Disease, STGD1
12/26
02/27
COCO-IRD, NCT06380075: COmparison of Clarus and Optos Ultrawide Field Imaging Systems for Inherited Retinal Disease

Recruiting
N/A
50
US
Spectralis FAF imaging, Optos imaging, Clarus imaging
University of Wisconsin, Madison
Retinal Disease
08/25
08/25
Uni-Rare, NCT05589714: Universal Rare Gene Study: A Registry and Natural History Study of Retinal Dystrophies Associated With Rare Disease-Causing Genetic Variants

Recruiting
N/A
1500
Europe, Canada, US, RoW
Jaeb Center for Health Research, Foundation Fighting Blindness
Inherited Retinal Degeneration, Retinitis Pigmentosa
12/28
12/28
Shaum, Katherine
NCT03187080: Enhanced Recovery Strategies in Elective Breast Surgery

Terminated
4
113
US
Paravertebral block procedure using either local anesthetic (0.25% bupivacaine) or sterile saline, Enhanced recovery after breast surgery (ERABS) strategies, Sham paravertebral block using saline, Paravertebral block using local anesthetic
University of Wisconsin, Madison
Pain, Acute, Nausea, Vomiting, Postoperative, Opioid Use, Satisfaction
06/21
06/21
Sachs, Jane
MAIA, NCT04307667: Microglia Activation in Asthma

Recruiting
N/A
50
US
Whole lung antigen challenge (WLAC), [18F]FEPPA
University of Wisconsin, Madison, National Institute on Aging (NIA), National Heart, Lung, and Blood Institute (NHLBI)
Asthma
08/28
08/28
Ross, Jonathan D
EAGLE-1, NCT04010539 / 2018-001780-23: A Study Evaluating Efficacy and Safety of Gepotidacin Compared With Ceftriaxone Plus Azithromycin in the Treatment of Uncomplicated Urogenital Gonorrhea

Completed
3
628
Europe, US, RoW
Gepotidacin, Ceftriaxone, Azithromycin
GlaxoSmithKline, BARDA
Gonorrhea
10/23
10/23
REMODEL-1, NCT05147220 / 2020-005899-36: Efficacy and Safety of Remibrutinib Compared to Teriflunomide in Participants With Relapsing Multiple Sclerosis (RMS)

Recruiting
3
800
Europe, US, RoW
Remibrutinib, LOU064, Teriflunomide
Novartis Pharmaceuticals, Novartis Pharma AG
Relapsing Multiple Sclerosis
04/26
10/30
Smith, Spencer J
NCT04568837: Steroids After Spine Fusion Surgery

Not yet recruiting
4
420
US
Prednisone 20 Mg, Dexamethasone Sodium Phosphate 1 mL 4 mg/mL
Oregon Health and Science University
Spine Fusion
10/26
10/26
NCT03737149: A Prospective Multicenter Longitudinal Cohort Study of the Mymobility Platform

Active, not recruiting
N/A
10500
Europe, US, RoW
mymobility with Apple Watch
Zimmer Biomet
Osteoarthritis, Knee, Osteoarthritis, Hip
12/24
07/25
NCT05923203: Combined Electric and Acoustic Hearing (EAS) in Children and Adults

Recruiting
N/A
160
US
Electric and acoustic stimulation (EAS) technology in the implanted ear(s)-this is the combination of a cochlear implant (CI) and hearing aid (HA) in the implanted ear(s)
Vanderbilt University Medical Center, National Institute on Deafness and Other Communication Disorders (NIDCD)
Cochlear Implant, Hearing Loss
06/28
08/28
NCT05787821: Persona OsseoTi Keel Compatibility Study (Total Knee Arthroplasty)

Recruiting
N/A
760
US
Total Knee Arthroplasty
Zimmer Biomet
Knee Pain Chronic, Osteoarthritis, Knee, Rheumatoid Arthritis, Traumatic Arthritis, Polyarthritis, Varus Deformity, Valgus Deformity, Flexion Deformity of Knee, Avascular Necrosis
06/26
06/35
Weingarten, Jerem
NCT04543461: American Lung Association (ALA) Lung Health Cohort

Recruiting
N/A
4000
US
Johns Hopkins University, National Heart, Lung, and Blood Institute (NHLBI), American Lung Association, Stanford University
Lung Diseases
09/26
09/26
Werning, Lisa M
NCT05045794: Bridge to HOPE: Hypothermic Oxygenated Perfusion Versus Cold Storage Prior to Liver Transplantation

Completed
N/A
219
US
VitaSmart Liver Machine Perfusion System, VitaSmart Liver Machine, Hypothermic oxygenated perfusion, Static cold storage
Bridge to Life Ltd.
End Stage Liver DIsease, Liver Failure
06/24
06/24
Stout, John T
Uni-Rare, NCT05589714: Universal Rare Gene Study: A Registry and Natural History Study of Retinal Dystrophies Associated With Rare Disease-Causing Genetic Variants

Recruiting
N/A
1500
Europe, Canada, US, RoW
Jaeb Center for Health Research, Foundation Fighting Blindness
Inherited Retinal Degeneration, Retinitis Pigmentosa
12/28
12/28
Suhkwal, Adarsh
NCT05045794: Bridge to HOPE: Hypothermic Oxygenated Perfusion Versus Cold Storage Prior to Liver Transplantation

Completed
N/A
219
US
VitaSmart Liver Machine Perfusion System, VitaSmart Liver Machine, Hypothermic oxygenated perfusion, Static cold storage
Bridge to Life Ltd.
End Stage Liver DIsease, Liver Failure
06/24
06/24
Leyser, Marcio
HYP01, NCT06042257: Guanfacine for Hyperactivity in Children with Down Syndrome (HYPEbeGONE_DS)

Recruiting
2
60
US
Guanfacine Hydrochloride Immediate Release, Placebo
Rachel G. Greenberg, MD, MB, MHS, The Emmes Company, LLC, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Hyperactivity in Children with Down Syndrome, Impulsivity in Children with Down Syndrome
11/25
02/26
Larson, Liana
MAIA, NCT04307667: Microglia Activation in Asthma

Recruiting
N/A
50
US
Whole lung antigen challenge (WLAC), [18F]FEPPA
University of Wisconsin, Madison, National Institute on Aging (NIA), National Heart, Lung, and Blood Institute (NHLBI)
Asthma
08/28
08/28

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