Universitatsspital Bern Trials

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Primary compl

Study compl

Pabst, Thomas

NCT02375204: Standard-Dose Combination Chemotherapy or High-Dose Combination Chemotherapy and Stem Cell Transplant in Treating Patients with Relapsed or Refractory Germ Cell Tumors

Active, not recruiting

420

Europe, US, RoW

paclitaxel, Taxol, ifosfamide, Ifex®, IFOS, cisplatin, CDDP, pegylated G-CSF, G-CSF, carboplatin, Paraplatin®, CBDCA, etoposide phosphate, VePesid®, Toposar®, VP16, stem cell reinfusion

Alliance for Clinical Trials in Oncology, National Cancer Institute (NCI), European Organisation for Research and Treatment of Cancer - EORTC, Movember Foundation, Institute of Cancer Research (ICR), United Kingdom, Cancer Research UK, UNICANCER, Irish Group CTI

Germ Cell Tumor, Teratoma, Choriocarcinoma, Germinoma, Mixed Germ Cell Tumor, Yolk Sac Tumor, Childhood Teratoma, Malignant Germ Cell Neoplasm, Extragonadal Seminoma, Non-seminomatous Germ Cell Tumor, Seminoma

06/31

HOVON 156 AML, NCT04027309 / 2018-000624-33: A Study of Gilteritinib Versus Midostaurin in Combination With Induction and Consolidation Therapy Followed by One-year Maintenance in Patients With Newly Diagnosed Acute Myeloid Leukemia or Myelodysplastic Syndromes With Excess Blasts-2 With FLT3 Mutations Eligible for Intensive Chemotherapy

Active, not recruiting

777

Europe, RoW

Gilteritinib, ASP2215, Midostaurin, Rydapt

Stichting Hemato-Oncologie voor Volwassenen Nederland, Deutsch-Österreichische Studiengruppe Akute Myeloische Leukämie (AMLSG), Astellas Pharma Global Development, Inc.

Acute Myeloid Leukemia, Myelodysplastic Syndrome With Excess Blasts-2

10/25

06/33

SAAL, NCT02646098: CD34+ Selected ASCT for Aggressive Lymphomas

Completed

Europe

CD34+ cell selection, CD34+ selection

Insel Gruppe AG, University Hospital Bern

Malignant Non-Hodgkin Lymphomas

10/18

11/23

PAMAL, NCT03238599: Pedometer Activity Monitoring After ASCT

Completed

Europe

Pedometer-based activity monitoring after ASCT

University Hospital Inselspital, Berne

Lymphoma, Myeloma, High-dose Chemotherapy, Autologous Stem Cell Transplantation

02/22

03/22

DREAMM 14, NCT05064358 / 2021-004151-16: Study to Investigate Alternative Dosing Regimens of Belantamab Mafodotin in Participants With Relapsed or Refractory Multiple Myeloma

Jul 2024 - Dec 2024 : Data for RRMM

Active, not recruiting

177

Europe, Canada, US, RoW

Belantamab mafodotin

GlaxoSmithKline

Multiple Myeloma

08/24

02/25

PRONTO, NCT06430736: Trial (PRophylactic Versus ON-demand Use of TOcilizumab)

Recruiting

100

Europe

Tocilizumab before CAR-T cell infusion, Prophylactic, Tocilizumab at emerging CRS, On demand

Insel Gruppe AG, University Hospital Bern

Myeloma, Lymphoma, Leukemia

12/26

06/27

OV-AML-1231, NCT06384261: A Study Comparing Venetoclax and Azacitidine Plus Cusatuzumab to Venetoclax and Azacitidine in Newly Diagnosed AML Ineligible for Intensive Therapy

Recruiting

120

Europe, Canada, US

Cusatuzumab, OV-1001, Venetoclax, Azacitidine

OncoVerity, Inc.

Leukemia, Myeloid, Acute

01/27

06/27

NCT05636787: Clinical Trial Investigating the Chemotherapeutic Compound Treosulfan (Trecondi® Ideogen) in Myeloma Patients

Recruiting

120

Europe

Treosulfan, Melphalan

Insel Gruppe AG, University Hospital Bern

Multiple Myeloma

01/28

04/28

NCT03187210: Brentuximab Vedotin and BeEAM High-dose Chemotherapy in Lymphomas

Suspended

1/2

Europe

Brentuximab Vedotin, BeEAM Regimen

Insel Gruppe AG, University Hospital Bern, Mundipharma Medical Company

Lymphoma

11/23

11/24

OMNIA-2, NCT05641324: A Study of ANV419 Alone or in Combination With Approved Treatments in Patients With Multiple Myeloma

Terminated

Europe

ANV419, Lenalidomide with low-dose dexamethasone, Daratumumab

Anaveon AG

Multiple Myeloma, Relapsed Cancer, Refractory Multiple Myeloma, Adult Disease, Hematologic Diseases

07/23

DARTT-1, NCT05732688: Drug-screening in AML at Relapse for Targeted Treatment

Completed

N/A

Europe

Image-based ex-vivo drug screening platform (pharmacoscopy), Pharmacoscopy

Insel Gruppe AG, University Hospital Bern

AML

04/24

07/24

Schultz, Marcus J

iHypoPRO, NCT05550181: Intraoperative Hypocapnia in PROVHILO and PROBESE

Completed

N/A

2793

Europe, RoW

intraoperative mechanical ventilation with hypocapnia (etCO2 < 35 mm Hg)

NMC Specialty Hospital, Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), Hospital Israelita Albert Einstein, University Hospital Carl Gustav Carus, Hospital Clínico Universitario de Valencia

Mechanical Ventilation Complication, Surgery, Pulmonary Complication, Intraoperative Complications, Postoperative Complications

01/23

03/23

INTELLiPOWER, NCT04827927: The Effect of Closed-Loop Versus Conventional Ventilation on Mechanical Power

Completed

N/A

Europe

Procedure: INTELLiVENT-ASV, Procedure: Conventional ventilation

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), Reinier de Graaf Groep, Dijklander Ziekenhuis, University of Zurich

Mechanical Ventilation, Mechanical Power

04/23

07/23

CONFIDENCE, NCT05188092: Lung Ultrasound-Guided Fluid Deresuscitation in ICU Patients

Recruiting

N/A

1000

Europe

Lung ultrasound guided deresuscitation

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), ZonMw: The Netherlands Organisation for Health Research and Development

Mechanical Ventilation, Fluid Overload, Deresuscitation, Ventilator-free Days

07/25

12/25

DESIGNATION, NCT03884543: Driving Pressure During General Anesthesia for Open Abdominal Surgery

Active, not recruiting

N/A

1468

Europe

Individualized high PEEP strategy

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), Amsterdam UMC, location VUmc, Noord West Ziekenhuizen location Alkmaar, University Medical Center Groningen, Radboud University Medical Center, HagaZiekenhuis, Rijnstate Hospital, Medical Center Haaglanden, Bernhoven Hospital, Onze Lieve Vrouwe Gasthuis, Albert Schweitzer Hospital, Medical Centre Leeuwarden, Leiden University Medical Center, Maastricht University Medical Center, Martini Hospital Groningen, Erasmus Medical Center, Spaarne Gasthuis, University Hospital Carl Gustav Carus, Bermanntrost BG Klinikum Halle, Heinrich-Heine University, Duesseldorf, Ospedale Policlinico San Martino, Jeroen Bosch Ziekenhuis, Meander Medical Center, Isala, Alrijne Hospital, Antoni van Leeuwenhoek Ziekenhuis, Medisch Spectrum Twente, Campus Bio-Medico University, Istituto Nazionale Tumori IRCCS - Fondazione G. Pascale, University of Roma La Sapienza, University of Campania Luigi Vanvitelli, Hospital Universitario La Fe, Medical University Innsbruck

Postoperative Respiratory Complication

12/24

06/25

PRIME, NCT06592937: Harmonized and Pooled Database, Named .

Completed

N/A

3270

Europe

Invasive ventilation

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Invasive Ventilation

07/24

PRoPERLy-II, NCT06589427: Prediction of PaO2 Values Using the PRoPERLy II Database

Completed

N/A

8000

Europe

Invasive ventilation., Respiratory support.

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Invasive Ventilation

07/24

BIG APPLE, NCT06166706: Current Practice of Ventilation Strategies in Children Undergoing General Anesthesia

Recruiting

N/A

10000

Europe, RoW

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Mechanical Ventilation Complication, Pediatric ALL, Pulmonary Complication, Perioperative/Postoperative Complications

04/25

05/25

NCT05345743: The Incidence of Postoperative Pulmonary Complications in Patients With a Positive and Negative AIR-Test During General Anesthesia

Completed

N/A

632

Europe

Surgery

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Surgery--Complications, Atelectasis, Anesthesia

06/24

PRoVent-PED, NCT06220825: PRactice of VENTilation in Critically Ill PEDiatric Patients

Recruiting

N/A

2500

Europe

University Medical Center Groningen, Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Critical Illness, Respiratory Failure

04/34

MEET VENUS, NCT06296277: Mechanical Ventilation in Surgical Patients

Not yet recruiting

N/A

10000

Intraoperative mechanical ventilation for surgery

Azienda Ospedaliero Universitaria Maggiore della Carita, University Of Perugia, University of Chieti, Medical University of Vienna, The Netherlands Cancer Institute, Monash University

Surgery, Ventilator Lung, Postoperative Complications

10/24

03/25

PRoFLUID, NCT05968066: Practice of Fluid Therapy in Critically Ill Invasively Ventilated Patients

Recruiting

N/A

2500

Europe

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), Mahidol Oxford Tropical Medicine Research Unit, Amsterdam UMC, location VUmc, University Hospital, Antwerp

Fluid Therapy, Vasopressor Therapy, Critical Illness, Invasive Ventilation

07/25

NCT04487769: Lung Ultrasound in COVID-19 Patients

Completed

N/A

137

Europe

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), Centre Hospitalier Universitaire de Brussels, Brussels, Belgium, Miulli Regional Hospital, Acquaviva delle Fonti, Italy, University of Foggia, University of Bari Aldo Moro

Covid19, Ultrasound, ARDS

12/20

ACTiVE, NCT04593810: Effect of Automated Closed-Loop Ventilation Versus Conventional Ventilation on Duration and Quality of Ventilation

Recruiting

N/A

1200

Europe

INTELLiVENT-ASV, CONVENTIONAL VENTILATION

Prof. Dr. Marcus J. Schultz, ZonMw: The Netherlands Organisation for Health Research and Development, Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), Catharina Ziekenhuis Eindhoven, Reinier de Graaf Groep, Flevoziekenhuis, Leiden University Medical Center, Canisius-Wilhelmina Hospital, Elisabeth-TweeSteden Ziekenhuis, Diakonessenhuis, Utrecht, Ospedale Policlinico San Martino, Fondazione IRCCS Policlinico San Matteo di Pavia

Ventilator-free Days, Quality of Breathing

03/25

06/25

ACACIA, NCT06027008: Mechanical Insufflation-Exsufflation (Cough Assist) in Critically Ill Adults

Terminated

N/A

Europe

Mechanical Insufflation-Exsufflation, Cough assist

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Critically Ill

10/24

GENERATOR, NCT06101511: Driving Pressure During General Anesthesia for Minimally Invasive Abdominal Surgery

Recruiting

N/A

1806

Europe

Intraoperative ventilation with individualized high PEEP titrated to the lowest ΔP with RMs, Individualized high PEEP strategy with recruitment maneuvers

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), Onze Lieve Vrouwe Gasthuis, HagaZiekenhuis, Dijklander Ziekenhuis, The Netherlands Cancer Institute, Isala, Maasstad Hospital, Medisch Spectrum Twente, University Medical Center Groningen, Leiden University Medical Center, Hospital Universitario La Fe, Ospedale Policlinico San Martino, University Hospital Carl Gustav Carus, Medical University Innsbruck, Spaarne Gasthuis, Zaans Medical Center, Alrijne Hospital, Albert Schweitzer Hospital, Maastricht University Medical Center, Noordwest Ziekenhuisgroep

Postoperative Complications, Surgery

06/27

09/27

Meenen, David MP van

iHypoPRO, NCT05550181: Intraoperative Hypocapnia in PROVHILO and PROBESE

Completed

N/A

2793

Europe, RoW

intraoperative mechanical ventilation with hypocapnia (etCO2 < 35 mm Hg)

Mechanical Ventilation Complication, Surgery, Pulmonary Complication, Intraoperative Complications, Postoperative Complications

01/23

03/23

BIG APPLE, NCT06166706: Current Practice of Ventilation Strategies in Children Undergoing General Anesthesia

Recruiting

N/A

10000

Europe, RoW

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Mechanical Ventilation Complication, Pediatric ALL, Pulmonary Complication, Perioperative/Postoperative Complications

04/25

05/25

PRoVENT-COP, NCT05650957: PRactice of VENTilation in Patients With ARDS Due to COVID-19 vs Pneumonia

Completed

N/A

7145

Europe, RoW

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), Carlos III Health Institute, University of Sao Paulo, National University of Ireland, Galway, Ireland, Amsterdam UMC

Acute Respiratory Distress Syndrome, COVID-19, Pneumonia, Mechanical Ventilation Complication

02/24

PROFLOW, NCT06703814: PROtective Ventilation With FLOW-Controlled Ventilation

Not yet recruiting

N/A

100

Europe

Intraoperative flow-controlled ventilation strategy, FCV, Intraoperative pressure-controlled ventilation strategy, PCV

Cantonal Hospital of St. Gallen, University Hospital Bergmannsheil Bochum, Luzerner Kantonsspital, Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Postoperative Pulmonary Complications (PPCs), Feasibility Studies, Pilot Study

05/25

06/25

GENERATOR, NCT06101511: Driving Pressure During General Anesthesia for Minimally Invasive Abdominal Surgery

Recruiting

N/A

1806

Europe

Intraoperative ventilation with individualized high PEEP titrated to the lowest ΔP with RMs, Individualized high PEEP strategy with recruitment maneuvers

Postoperative Complications, Surgery

06/27

09/27

Investigator, Madrigal

MAESTRO-NASH, NCT03900429 / 2018-004012-22: A Phase 3 Study to Evaluate the Efficacy and Safety of MGL-3196 (Resmetirom) in Patients With NASH and Fibrosis

Active, not recruiting

1759

Europe, Canada, US, RoW

MGL-3196, Resmetirom, Placebo, Liver Biopsy

Madrigal Pharmaceuticals, Inc.

NASH - Nonalcoholic Steatohepatitis

01/28

NCT04951219: A Phase 3 Study to Evaluate Safety and Biomarkers of Resmetirom (MGL-3196) in Patients With Non-alcoholic Fatty Liver Disease (NAFLD), MAESTRO-NAFLD-Open-Label-Extension (MAESTRO-NAFLD-OLE)

Recruiting

1000

Resmetirom, MGL-3196

Madrigal Pharmaceuticals, Inc.

Non-Alcoholic Fatty Liver Disease

03/26

04/26

NCT04643795: Phase 1 Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of Multiple Oral Doses of MGL-3196 in Subjects With Varying Degrees of Hepatic Impairment and Healthy Matched Control Subjects

Completed

MGL-3196

Madrigal Pharmaceuticals, Inc.

Hepatic Impairment, NASH - Nonalcoholic Steatohepatitis, Cirrhosis, Liver

08/21



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