| Ulrich, Silvia |
NCT03537924: Effect of Acetazolamide on Right Heart Function During Exercise in Lowlanders Older Than 40 Years at Altitude |
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| Active, not recruiting | 4 | 100 | RoW | ACETAZOLAMIDE oral capsule, Placebo oral capsule | University of Zurich, National Center of Cardiology and Internal Medicine named after academician M.Mirrakhimov | Altitude Hypoxia | 12/22 | 12/22 | | |
NCT03539367: Effect of Acetazolamide on Lung Water Content by Ultrasound in Lowlanders Older Than 40 Years at Altitude |
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| Active, not recruiting | 4 | 100 | RoW | ACETAZOLAMIDE oral capsule, Placebo oral capsule | University of Zurich, National Center of Cardiology and Internal Medicine named after academician M.Mirrakhimov | Altitude Hypoxia | 12/22 | 12/22 | | |
NCT06498505: HighCycle: Effect of Acetazolamide on Pulmonary Artery Pressure in Women Compared to Men |
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| Recruiting | 4 | 270 | RoW | Acetazolamide, Placebo | University of Zurich, National Center of Cardiology and Internal Medicine named after academician M.Mirrakhimov, University Hospital Heidelberg, Laboratoire des Adaptations Métaboliques à l'Exercice en conditions Physiologiques et Pathologiques | High Altitude | 12/25 | 12/25 | | |
NCT03540914: Effect of Acetazolamide on Right Heart Function at Rest in Lowlanders Older Than 40 Years at Altitude. |
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| Active, not recruiting | 4 | 400 | RoW | ACETAZOLAMIDE oral capsule, Placebo oral capsule | University of Zurich, National Center of Cardiology and Internal Medicine named after academician M.Mirrakhimov | Altitude Hypoxia | 12/24 | 12/24 | | |
NCT04915365: Effect of Acetazolamide on Right Heart Function at Rest in Lowlanders With COPD Traveling to High Altitude |
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| Recruiting | 3 | 100 | RoW | Acetazolamide, Acetazolamide, oral capsule, Placebo, Placebo, oral capsule | University of Zurich, National Center of Cardiology and Internal Medicine, Kyrgyz Republic | Right Heart Function, Chronic Obstructive Pulmonary Disease, Altitude Sickness | 12/22 | 12/23 | | |
ESRA, NCT05339087: Efficacy and Safety of Riociguat in Incipient Pulmonary Vascular Disease as an Indicator for Early PAH |
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| Recruiting | 2 | 70 | Europe | Riociguat Oral Tablet, MK-4836, ATC Code: C02KX05, Placebo | Heidelberg University, Merck Sharp & Dohme LLC | Pulmonary Vascular Disorder, Primary Pulmonary Hypertension, Systemic Sclerosis, Other Systemic Involvement of Connective Tissue | 10/25 | 06/26 | | |
PEGASUS, NCT03051763: The Effects of Commercial Air Travel on Patients Suffering From Pulmonary Hypertension |
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| Recruiting | N/A | 1000 | Europe | | University of Giessen, Universitätsklinikum Hamburg-Eppendorf, DRK Kliniken Berlin Köpenick, Berlin, Germany, University Hospital, Zürich, University Hospital Carl Gustav Carus | Pulmonary Hypertension, Pulmonary Arterial Hypertension | 12/21 | 05/22 | | |
NCT05185895: Visa-versa! Breaking Instead of Pushing the Pedals-D |
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| Completed | N/A | 24 | Europe | 15 minutes eccentric cycling, 15 minutes concentric (normal) cycling | University of Zurich | Healthy (Controls) | 12/22 | 04/23 | | |
NCT05186987: Visa-versa! Breaking Instead of Pushing the Pedals-A |
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| Completed | N/A | 33 | Europe | 15 minutes eccentric cycling, 15 minutes concentric (normal) cycling | University of Zurich | Pulmonary Hypertension | 08/23 | 09/23 | | |
HEXASN, NCT04706546: Hemodynamic Effects During Exercise in Patients With Pulmonary Hypertension Receiving Sildenafil |
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| Completed | N/A | 24 | Europe | Hemodynamic effect of exercise under Sildenafil, Hemodynamic effect of exercise | University of Zurich | Hypertension, Pulmonary | 05/23 | 05/23 | | |
HEXABM, NCT04715113: Blood Markers Predict Effect of Normobaric Hypoxia at Rest and During Exercise in Patients With Pulmonary Hypertension |
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| Completed | N/A | 24 | Europe | Normobaric hypoxia (FiO2 15%), Placebo-ambient air (FiO2 21%), Normobaric hypoxia (FiO2 15%) under Sildenafil, Placebo-ambient air (FiO2 21%) under Sildenafil | University of Zurich | Hypertension, Pulmonary | 05/23 | 05/23 | | |
HEXASH, NCT04697862: Effects of Normobaric Hypoxia During Exercise in Patients With Pulmonary Hypertension Receiving Sildenafil |
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| Completed | N/A | 24 | Europe | Normobaric hypoxia (FiO2 15%) under Sildenafil, Normobaric hypoxia (FiO2 15%) | University of Zurich | Hypertension, Pulmonary | 05/23 | 05/23 | | |
HEXAS, NCT04704440: Effects of Normobaric Hypoxia During Exercise in Patients With Pulmonary Hypertension With/Without Sildenafil |
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| Completed | N/A | 24 | Europe | Normobaric hypoxia (FiO2 15%), Placebo-ambient air (FiO2 21%), Normobaric hypoxia (FiO2 15%) under Sildenafil, Placebo-ambient air (FiO2 21%) under Sildenafil | University of Zurich | Hypertension, Pulmonary | 05/23 | 05/23 | | |
HEXA, NCT04697875: Hemodynamic Effects of Normobaric Hypoxia During Exercise in Patients With Pulmonary Hypertension |
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| Completed | N/A | 24 | Europe | Normobaric hypoxia (FiO2 15%), Placebo-ambient air (FiO2 21%) | University of Zurich | Hypertension, Pulmonary | 05/23 | 05/23 | | |
| Recruiting | N/A | 1500 | Europe, US, RoW | assessment of pulmonary hemodynamics during exercise by right heart catheterization | Medical University of Graz, European Respiratory Society | Pulmonary Circulation Diseases | 12/29 | 12/29 | | |
NCT05204693: Visa-versa! Breaking Instead of Pushing the Pedals-C |
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| Recruiting | N/A | 16 | Europe | 15 minutes eccentric cycling, 15 minutes concentric (normal) cycling | University of Zurich | Left Heart Failure | 12/23 | 07/24 | | |
NCT05185856: Visa-versa! Breaking Instead of Pushing the Pedals-B |
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| Recruiting | N/A | 16 | Europe | 15 minutes eccentric cycling, 15 minutes concentric (normal) cycling | University of Zurich | Chronic Obstructive Pulmonary Disease | 07/24 | 12/24 | | |
NCT05996302: HA Residents With PVD, 6MWD Assessed at HA (2840m) vs LA (Sea Level) |
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| Active, not recruiting | N/A | 24 | Europe | Relocation to sea level | University of Zurich | Pulmonary Vascular Disease, Pulmonary Artery Hypertension, Chronic Thromboembolic Pulmonary Hypertension | 12/23 | 12/23 | | |
NCT06084559: HA Residents With PVD, Pulmonary Artery Pressure (PAP) Assessed at HA (2840m) With and Without Supplemental Oxygen Therapy (SOT) |
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| Active, not recruiting | N/A | 24 | Europe | Supplemental oxygen therapy, Sham Oxygen therapy, Placebo | University of Zurich | Pulmonary Vascular Disorder, Pulmonary Artery Hypertension, Chronic Thromboembolic Pulmonary Hypertension | 12/23 | 12/23 | | |
NCT06072417: HA Residents With PVD, SDB Assessed at HA (2840m) vs LA (Sea Level) |
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| Active, not recruiting | N/A | 24 | Europe | Assessment without intervention at High altitude, Relocation to sea level for 2 days | University of Zurich | Pulmonary Vascular Disease, Pulmonary Artery Hypertension, Chronic Thromboembolic Pulmonary Hypertension | 12/23 | 12/23 | | |
NCT06003244: High Altitude (HA) Residents With Pulmonary Vascular Diseases (PVD), 6 Minute Walk Distance (6MWD) Assessed at 2840m (HA) With and Without Supplemental Oxygen Therapy (SOT) |
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| Active, not recruiting | N/A | 24 | Europe | 6-minute walk distance (6MWD) test, 6-minute walk distance (6MWD) test with supplemental oxygen (3 l/min, nasal) | University of Zurich | Pulmonary Vascular Disease, Pulmonary Artery Hypertension, Chronic Thromboembolic Pulmonary Hypertension | 12/23 | 12/23 | | |
NCT06385301: Exercise Performance on Ambient Air vs. Low-Flow Oxygen Therapy With Chronic Lung Diseases |
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| Not yet recruiting | N/A | 14 | Europe | 6-minute walk distance (6MWD) test on ambient air, 6-minute walk distance test with supplemental oxygen (approximately 3l/min, nasal) | University of Zurich | Lung Disease Chronic, Lung Diseases, Interstitial, Lung Diseases, Obstructive | 05/25 | 11/25 | | |
NCT06384534: Exercise Performance on Ambient Air vs. Low-Flow Oxygen Therapy in Pulmonary Vascular Disease (PVD) |
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| Not yet recruiting | N/A | 28 | Europe | 6-minute walk distance (6MWD) test on ambient air, 6-minute walk distance test with supplemental oxygen | University of Zurich | Pulmonary Vascular Disorder, Chronic Thromboembolic Pulmonary Hypertension, Pulmonary Arterial Hypertension | 05/25 | 11/25 | | |
NCT06489704: High Altitude (HA) Residents With High Altitude Pulmonary Hypertension (HAPH), Pulmonary Artery Pressure (PAP) Assessed at HA (3200 m) vs LA (760 m) |
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| Not yet recruiting | N/A | 24 | RoW | Echocardiography | University of Zurich | High Altitude Pulmonary Hypertension | 12/24 | 12/24 | | |
NCT06489743: Highlanders With High Altitude Pulmonary Hypertension (HAPH), 6 Minute Walk Distance (6MWD) Assessed at 3200m With and Without Supplemental Oxygen Therapy (SOT) |
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| Not yet recruiting | N/A | 24 | RoW | 6-minute walk test (6MWT) | University of Zurich | High Altitude Pulmonary Hypertension | 12/24 | 12/24 | | |
NCT06489756: Highlanders With High Altitude Pulmonary Hypertension (HAPH), Pulmonary Arterial Pressure (PAP) Assessed at 3200m With and Without Supplemental Oxygen Therapy (SOT) |
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| Not yet recruiting | N/A | 24 | RoW | Echocardiography | University of Zurich | High Altitude Pulmonary Hypertension | 12/24 | 12/24 | | |
NCT06489691: High Altitude Residents With High Altitude Pulmonary Hypertension (HAPH), 6MWT Assessed at High Altitude (3200m) vs Low Altitude (760m) |
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| Not yet recruiting | N/A | 24 | RoW | 6-minute walk test (6MWT) | University of Zurich | High Altitude Pulmonary Hypertension | 12/24 | 12/24 | | |
NCT06489717: High Altitude Residents With High Altitude Pulmonary Hypertension (HAPH), SDB Assessed at HA (3200 m) vs LA (760 m) |
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| Not yet recruiting | N/A | 24 | RoW | SDB assessment | University of Zurich | High Altitude Pulmonary Hypertension | 12/24 | 12/24 | | |
NCT06489730: HAPH Registry: Time Course and Prognostic Significance of Pulmonary Artery Pressure in Highlanders. |
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| Not yet recruiting | N/A | 120 | NA | | University of Zurich, National Center of Cardiology and Internal Medicine named after academician M.Mirrakhimov | High Altitude Pulmonary Hypertension, Sleep Apnea | 12/24 | 12/24 | | |
| Recruiting | N/A | 100 | Europe | PH target therapy according to physician | University of Zurich | Pulmonary Hypertension Outcome Assessment | 09/24 | 09/24 | | |
| Recruiting | N/A | 1000 | Europe | | University of Zurich, Actelion | Pulmonary Hypertension | 12/27 | 12/27 | | |
| Guckenberger, Matthias |
DOSIS RCT, NCT02800551: Clinical Trial Comparing Dose-intensified SBRT With Conventional Radiation Therapy for Spinal Metastases |
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| Active, not recruiting | 2 | 219 | Europe | dose-intensified image-guided SBRT using simultaneous integrated boost, External 3-dimensional conformal radiotherapy (3D-CRT) | University of Zurich | Spinal Metastasis | 01/23 | 07/24 | | |
| Recruiting | 2 | 90 | Europe | Durvalumab, Radiotherapy | Swiss Group for Clinical Cancer Research | Non-small Cell Lung Cancer, NSCLC | 12/25 | 12/31 | | |
| Recruiting | 2 | 92 | Europe | SBRT, oMRgRT, SOC chemotherapy | Ludwig-Maximilians - University of Munich, Heidelberg University, University of Zurich | Pancreatic Cancer | 12/23 | 05/24 | | |
AUSTRAL, NCT06680050: Phase II Study of Radiotherapy Followed by Durvalumab (MEDI4736) and Ceralasertib (AZD6738) in Stage III NSCLC Patients With Thoracic Relapses +/- Oligometastases After PACIFIC Regimen |
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| Not yet recruiting | 2 | 21 | Europe | Durvalumab (MEDI4736), Ceralasertib, radiotherapy | Mario Negri Institute for Pharmacological Research | Non Small Cell Lung Cancer NSCLC | 01/27 | 01/28 | | |
| Terminated | 2 | 6 | Europe, RoW | Osimertinib, Tagrisso, Stereotactic Body Radiation Therapy (SBRT) | ETOP IBCSG Partners Foundation, AstraZeneca | NSCLC Stage IV, EGFR Gene Mutation | 10/23 | 02/24 | | |
| Recruiting | 2 | 96 | Europe | Durvalumab, Imfinzi, Carboplatin, Paclitaxel, Stereotactic body radiation therapy (SBRT), Surgical resection - definitive local treatment., Radical radiotherapy - definitive local treatment., Tremelimumab | ETOP IBCSG Partners Foundation, AstraZeneca | Non-small Cell Lung Cancer, Stage IV, Oligometastasis | 08/26 | 12/26 | | |
| Recruiting | N/A | 2000 | Europe, RoW | | European Organisation for Research and Treatment of Cancer - EORTC | Cancer | 04/26 | 04/26 | | |
SPRINT, NCT06462963: OligoCare TwiCs (Trials Within Cohorts) Trial Comparing Acute Toxicity in Single-fraction vs Multiple-fraction SBRT for Metastasis-directed Treatment |
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| Not yet recruiting | N/A | 302 | NA | single-fraction SBRT, multiple-fraction SBRT | European Organisation for Research and Treatment of Cancer - EORTC | Breast Cancer, Prostate Cancer, NSCLC, Colorectal Cancer, Oligometastatic Disease | 11/28 | 11/28 | | |
HypoFocal SRT, NCT05746806: Trial of Ultrahypofractionated Focal Salvage Radiotherapy for Isolated Prostate Bed Recurrence After Radical Prostatectomy |
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| Recruiting | N/A | 36 | Europe | Ultrahypofractionated salvage radiotherapy to a local recurrence after radical prostatectomy, Androgen deprivation therapy | Insel Gruppe AG, University Hospital Bern, University of Bern, Debiopharm International SA, Werner und Hedy Berger-Janser - Stiftung | Recurrent Prostate Cancer | 09/25 | 08/27 | | |
| Recruiting | N/A | 200 | Europe | Stereotactic body radiotherapy, SBRT, Palliative RT | European Organisation for Research and Treatment of Cancer - EORTC, Anticancer Fund, Belgium, Rising Tide Foundation | Gynecologic Cancer, Skin Cancer, Head and Neck Cancer, Sarcoma, Renal Cancer, Bladder Cancer, Upper Urinary Tract Carcinoma, Pancreatic Cancer, Hepatobiliary Cancer, Gastric Cancer, Small Bowel Cancer, Esophageal Cancer, Melanoma, Colon Cancer, Oligometastasis | 08/28 | 02/30 | | |
| Maisano, Francesco |
| Not yet recruiting | 4 | 250 | Europe, RoW | Early transcatheter edge-to-edge mitral valve repair (TEER)., MitraClip, Optimal medical treatment | Fundación para la Investigación Biosanitaria del Principado de Asturias, Meditrial Europe Ltd. | Acute Mitral Regurgitation | 06/27 | 06/28 | | |
OPTIMAV, NCT06667128: Optimization of Heart Failure (HF) Medical Therapy After Transcatheter Valve Intervention (TVI) in Patients With Heart Failure With Reduced Ejection Fraction (HFrEF) |
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| Not yet recruiting | N/A | 160 | Europe | Rapid Uptitration of Guideline-Directed Medical Therapy, Elecsys® NT-proBNP - Roche Diagnostics, Point-of-Care (PoC) Monitoring, Rapid Up-Titration GDMT Group with Hospital Monitoring | IRCCS Ospedale San Raffaele, Hoffmann-La Roche | Heart Failure, Valvulopathy, Aortic Stenosis, Aortic Regurgitation Disease, Mitral Regurgitation, Tricuspid Regurgitation, Brain Natriuretic Peptide, Mitraclip, TAVI(Transcatheter Aortic Valve Implantation) | 02/26 | 02/26 | | |
| Not yet recruiting | N/A | 168 | NA | DragonFly Transcatheter Mitral Valve Repair System, Transcatheter Mitral Valve repair (TMVr) | Hangzhou Valgen Medtech Co., Ltd | Mitral Valve Insufficiency | 05/25 | 05/29 | | |
| Recruiting | N/A | 590 | Europe, RoW | Navitor Transcatheter Aortic Valve and FlexNav Delivery System | Abbott Medical Devices | Symptomatic Severe Aortic Stenosis | 06/25 | 02/36 | | |
| Recruiting | N/A | 1000 | Europe, Japan | Navitor Transcatheter Aortic Valve, FlexNav Delivery System, Navitor Loading System | Abbott Medical Devices | Aortic Stenosis | 01/26 | 12/30 | | |
APOLLO-EU, NCT05496998: Transcatheter Mitral Valve Replacement in Patients With Severe Symptomatic Mitral Regurgitation - Trial |
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| Recruiting | N/A | 400 | Europe | Medtronic Intrepid™ TMVR TF System | Medtronic Cardiovascular | Mitral Regurgitation | 08/29 | 12/38 | | |
| Kulcsar, Zsolt |
TECNO, NCT05499832: Safety and Efficacy of Intra-arterial Tenecteplase for Noncomplete Reperfusion of Intracranial Occlusions |
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| Recruiting | 3 | 156 | Europe | Tenecteplase | Insel Gruppe AG, University Hospital Bern | Ischemic Stroke | 07/25 | 10/25 | | |
IMPACT, NCT04572230: International Post Market Surveillance Study of Intracranial Aneurysms Treated With an Endovascular Approach |
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| Active, not recruiting | N/A | 405 | Europe | Endovascular treatment of intracranial aneurysms using a flow-diverting stent | Stryker Neurovascular | Intracranial Aneurysm | 09/24 | 09/25 | | |
DISTAL, NCT05029414: EnDovascular Therapy Plus Best Medical Treatment (BMT) Versus BMT Alone for MedIum VeSsel Occlusion sTroke |
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| Active, not recruiting | N/A | 543 | Europe, RoW | Endovascular Therapy | University Hospital, Basel, Switzerland, Swiss National Fund for Scientific Research, Stryker Neurovascular, Penumbra Inc., Medtronic, Phenox GmbH, Rapid Medical, Gottfried und Julia Bangerter-Rhyner-Stiftung | Acute Ischemic Stroke | 10/24 | 06/25 | | |
| Achermann, Yvonne |
| Recruiting | 1 | 20 | Europe | Photodynamic Therapy | University of Zurich | Prosthesis and Implants, Surgical Site Infection, Prosthetic Joint Infection, Postoperative Wound Infection Deep Incisional Surgical Site | 09/23 | 12/23 | | |
| Rose, Elizabeth |
IMPACT, NCT04572230: International Post Market Surveillance Study of Intracranial Aneurysms Treated With an Endovascular Approach |
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| Active, not recruiting | N/A | 405 | Europe | Endovascular treatment of intracranial aneurysms using a flow-diverting stent | Stryker Neurovascular | Intracranial Aneurysm | 09/24 | 09/25 | | |
| Schiebler, Sarah |
NCT05168124: Effectiveness of Acceptance Commitment Therapy or Micro Breaks in Patients with Chronic Fatigue Syndrome/ Myalgic Encephalomyelitis |
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| Recruiting | N/A | 90 | Europe | Acceptance Commitment Therapy for chronic fatigue, Micro breaks in everyday life for chronic fatigue | Sarah Schiebler, University of Zurich | Fatigue Syndrome, Chronic | 12/25 | 07/26 | | |
| Deuel, Jeremy |
| Recruiting | N/A | 130 | Europe | Secondary electrospray ionization high-resolution mass spectrometry (SESI-HRMS), Blood sampling (serologic biomarkers, PCR), Sputum analysis, Low-dose CT | University of Zurich | Leukemia, Leukemia, Myeloid, Leukemia, Lymphoblastic, Neutropenia, Chemotherapy-induced Neutropenia, Invasive Fungal Infections, Invasive Pulmonary Aspergillosis | 08/26 | 02/27 | | |
