University of Connecticut Health Center
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 59 Trials 
79 Trials

   

 
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Metersky, Mark
NCT05079620: Early Antibiotics After Aspiration in ICU Patients

Terminated
4
5
US
Ceftriaxone, Amoxicillin clavulanic acid, Augmentin, Cefepime, Vancomycin, Levofloxacin
UConn Health
Aspiration, Aspiration Pneumonia
04/24
04/24
TOLD, NCT04424901: Trial of Open Label Dipyridamole- In Hospitalized Patients With COVID-19

Terminated
2
41
US
Placebo, Dipyridamole Tablets, Persantine
UConn Health
COVID-19 Pneumonia, Vascular Complications
03/22
04/22
Tailwind, NCT05616221: Study to Evaluate the Safety, Phage Kinetics, and Efficacy of Inhaled AP-PA02 in Subjects With Non-Cystic Fibrosis Bronchiectasis and Chronic Pulmonary Pseudomonas Aeruginosa Infection

Completed
2
48
US
AP-PA02, Placebo
Armata Pharmaceuticals, Inc.
Non-cystic Fibrosis Bronchiectasis, Pseudomonas Aeruginosa, Lung Infection
07/24
08/24
Litt, Mark D
NCT05862870: TMD Online Program for Pain Management

Completed
N/A
21
US
painTRAINER
UConn Health, National Institute of Dental and Craniofacial Research (NIDCR)
TMD/Orofacial Pain
08/23
08/23
NCT04376333: Individualized Assessment and Treatment for TMD

Recruiting
N/A
160
US
Cognitive-Behavioral Treatment, CBT, Individualized Assessment and Treatment Program, IATP, Standard Conservative Care, STD
UConn Health, National Institute of Dental and Craniofacial Research (NIDCR)
Temporomandibular Joint Disorders, Orofacial Pain
01/25
06/26
Ginsburg, Golda S
TEAMSS, NCT05145387: Transitioning Emotionally and Academically to Middle School Successfully

Recruiting
N/A
42
US
Transitioning Emotionally and Academically to Middle School Successfully (TEAMSS)
UConn Health
Anxiety Disorders
05/25
06/25
NCT04693858: Efficacy Trial of the CALM Intervention

Recruiting
N/A
218
US
Child Anxiety Learning Modules (CALM), Child Anxiety Learning Modules--Relaxation (CALM-R)
UConn Health
Anxiety Disorder of Childhood
07/26
07/26
MAPP, NCT06104904: Managing Anxiety in Pediatric Primary Care

Recruiting
N/A
60
US
MAPP
UConn Health, National Institutes of Health (NIH), National Institute of Mental Health (NIMH)
Anxiety, Anxiety Disorders
01/26
01/26
Brewer, Molly A
FLORA-4, NCT04498117 / 2020-002270-26: Oregovomab Plus Chemo in Newly Diagnosed Patients With Advanced Epithelial Ovarian Cancer Following Optimal Debulking Surgery

Active, not recruiting
3
615
Europe, Canada, US, RoW
Oregovomab, MAb-B43.13, Paclitaxel, Taxol, Carboplatin, Paraplatin, Placebo
CanariaBio Inc., Gynecologic Oncology Group, Iqvia Pty Ltd
Carcinoma, Ovarian Epithelial, Ovarian Neoplasms, Ovarian Cancer, Ovarian Serous Adenocarcinoma, Fallopian Tube Neoplasms, Fallopian Tube Adenocarcinoma, Fallopian Tube Serous Adenocarcinoma, Peritoneal Cancer, Peritoneal Carcinoma, Peritoneal Neoplasms
09/25
08/27
Oncken, Cheryl A
NCT04098302: Dutasteride Treatment for Reducing Heavy Drinking in AUD: Predictors of Efficacy

Completed
2/3
180
US
Dutasteride Capsules, Avodart, Placebo Capsules, inactive placebo
UConn Health, National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Alcohol Use Disorder
06/24
06/24
lewis, catherine f
RIOT-2, NCT06016179: Tocilizumab Delivered Via Pleural and Peritoneal Catheters in Patients With Advanced Metastatic Cancer

Recruiting
1
12
US
Tocilizumab, Actemra
Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
Malignant Pleural Effusion, Malignant Ascites
01/26
01/27
Engmann, Lawrence
NCT04744025: Microfluidics Versus Gradient Centrifugation Effect on Euploidy Rates

Active, not recruiting
N/A
150
US
Microfluidics chamber, ZyMot Fertility (device brand name), Density Gradient Centrifugation
Lawrence Engmann, The Center for Advanced Reproductive Services, P.C., ZyMot Fertility
Infertility, Recurrent Pregnancy Loss
08/22
12/22
Kranzler, Henry R
NCT05028062: Naltrexone in AUD Reward Drinkers

Recruiting
4
60
US
XR-NTX 380 mg, intramuscular injection, Vivitrol naltrexone for extended-release injectable suspension, Medical Management, Placebo intramuscular injection, Inactive placebo
University of Pennsylvania, Alkermes, Inc.
Alcohol Use Disorder, Alcoholism
11/25
11/26
NCT04616781: Ketone Ester Intervention in Alcohol Use Disorder

Recruiting
2/3
20
US
Ketone Ester "(R)-3-hydroxybutyl (R)-3-hydroxybutyrate", Delta G, Isocaloric dextrose placebo, Alcohol drinks
University of Pennsylvania, National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Alcohol Drinking, Alcohol Use Disorder
01/26
12/26
NCT06173973: Effects of Ketone Supplementation on Acute Alcohol Withdrawal

Enrolling by invitation
2/3
50
US
Kenetik; Ketone Concentrate, D-hydroxybutyric acid and R-1,3 butanediol, Isocaloric dextrose placebo
University of Pennsylvania
Alcohol Use Disorder, Alcohol Withdrawal, Alcohol Dependence, Ketosis
12/26
12/27
NCT05015881: Relationship Between Brain and Heart Glucose Metabolism in Alcohol Use Disorder

Enrolling by invitation
2/3
20
US
Ketone Ester "(R)-3-hydroxybutyl (R)-3-hydroxybutyrate", DeltaG, FDG, 2-Deoxy-2-[18F] fluoro-D-glucose (FDG)
University of Pennsylvania
Alcohol Use Disorder (AUD), Alcohol Drinking
12/25
12/26
NCT05551754: Acute Effects of Ketone Supplement on Responses to Alcohol Challenge in Healthy Volunteers

Active, not recruiting
2/3
10
US
Ketone Supplement, ketone supplement, D-hydroxybutyric acid and 1,3 butanediol, Alcohol Beverage
University of Pennsylvania
Alcohol Drinking
07/25
07/26
KSAW, NCT06559995: Effects of Ketone Supplementation on Alcohol Withdrawal and Brain Metabolism in Alcohol Use Disorder

Not yet recruiting
2/3
30
US
ketone supplement "D-beta-hydroxybutryric acid and R-1,3 butanediol" 12g of ketones,, Kenetik: Ketone Drink, VitaNav Inc., Washington D.C., magnetic resonance imaging session, MRI, Placebo beverage, Placebo
University of Pennsylvania, National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Alcohol Use Disorder, Alcohol Withdrawal, Ketosis
12/27
12/27
KAM, NCT06065657: Effect of Nutritional Ketosis on Alcohol Metabolism

Recruiting
2/3
20
US
Ketone Supplement, D-Beta-hydroxybutyric acid and R-1,3 butanediol, Control Diet, ~ 50% kcal carbohydrates diet, Ketogenic diet, ~5-10% kcal carbohydrates diet, Ethanol, Alcohol
University of Pennsylvania
Ketoses, Metabolic, Ketogenic Dieting, Alcohol Intoxication, Magnetic Resonance Imaging, Alcohol Drinking
12/25
12/26
NCT05414240: Ibudilast for Treating Alcohol Use Disorder

Recruiting
2
50
US
Ibudilast, MN-166, previously known as AV411 and the formulation is 10-mg delayed-release Pinatos® capsules, Medical management, Placebo, Inactive substance
University of Pennsylvania
Alcohol Use Disorder (AUD), Alcoholism
12/27
12/28
NCT05948605: EMPOWER AUD Pivotal Trial

Active, not recruiting
N/A
128
US
Empower Neuromodulation System
Theranova, L.L.C.
Alcoholism, Alcohol Abuse, Alcohol Use Disorder
03/25
05/25
Alessi, Sheila M
Peth, NCT04064463: Dual Reinforcement Contingency Management for Alcohol Use Disorders

Recruiting
N/A
150
US
Standard care, Contingency management
UConn Health, National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Alcohol Use Disorder, Contingency Management
05/25
05/25
Lalla, Rajesh V
ORARAD II, NCT05325970: Clinical Registry of Long-Term Dental Outcomes in Head and Neck Cancer Patients

Active, not recruiting
N/A
350
US
Wake Forest University Health Sciences, National Institute of Dental and Craniofacial Research (NIDCR), University of Minnesota, UConn Health, University of Pennsylvania, Brigham and Women's Hospital, NYU Langone Health, University of North Carolina
Head and Neck Cancer, Dental Diseases, Osteoradionecrosis
06/25
06/25
ORARAD, NCT02057510: Observational Study of Dental Outcomes in Head and Neck Cancer Patients

Active, not recruiting
N/A
575
US
Wake Forest University Health Sciences, National Institute of Dental and Craniofacial Research (NIDCR), University of Minnesota, UConn Health, University of Pennsylvania, Brigham and Women's Hospital, NYU Langone Health, University of North Carolina
Head and Neck Cancer, Dental Disease, Xerostomia, Osteoradionecrosis
06/25
06/25
Winokur, Andrew
DepWatch, NCT06292221: Personalized Depression Treatment Supported by Mobile Sensor Analytics

Recruiting
N/A
128
US
A mobile Health (mHealth) tool called 'DepWatch'
UConn Health, National Institute of Mental Health (NIMH)
Depression
04/25
06/25
Kaminer, Yifrah
InTEGRA, NCT06395467: 12-Step Facilitation/MET/CBT () vs. MET/CBT for Youth With Alcohol and Other Drug Use Disorder

Not yet recruiting
N/A
294
US
InTEGRA, MET/CBT
Massachusetts General Hospital, National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Alcohol Use Disorder, Cannabis Use Disorder
04/27
04/27
Arias, Albert J
NCT05886582: Transdermal Rotigotine as Adjunct to Behavioral Therapy for Cocaine Use Disorder

Recruiting
2
60
US
Rotigotine Transdermal System [Neupro], Placebo
Virginia Commonwealth University, National Institute on Drug Abuse (NIDA)
Substance-Related Disorders
06/26
06/26
Covault, Jonathan
NCT04098302: Dutasteride Treatment for Reducing Heavy Drinking in AUD: Predictors of Efficacy

Completed
2/3
180
US
Dutasteride Capsules, Avodart, Placebo Capsules, inactive placebo
UConn Health, National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Alcohol Use Disorder
06/24
06/24
Liang, Bruce T
TOLD, NCT04424901: Trial of Open Label Dipyridamole- In Hospitalized Patients With COVID-19

Terminated
2
41
US
Placebo, Dipyridamole Tablets, Persantine
UConn Health
COVID-19 Pneumonia, Vascular Complications
03/22
04/22
NCT04321512: Study of Circulating Monocytes in Patients With Ischemic Vascular Disease

Recruiting
N/A
300
US
There is no intervention given to the subjects
UConn Health
Myocardial Infarction, Stroke, Ischemic, Ischemia
02/25
02/25
NCT00762333: Circulating Markers for Ischemic Heart Disease

Recruiting
N/A
550
US
UConn Health
Myocardial Infarction, Ischemia, Congestive Heart Failure
03/26
03/26
NCT00762008: Circulating Markers That Underlie the Transition From Compensated Hypertrophy to Heart Failure

Recruiting
N/A
500
US
UConn Health, CT Department of Public Health
Acute Decompensated Heart Failure, Heart Failure
09/25
09/25
White, William B
MANIFEST-2, NCT04603495 / 2020-001989-10: Phase 3 Study of Pelabresib (CPI-0610) in Myelofibrosis (MF)

Jan 2024 - Dec 2024: Approval for myelofibrosis
Hourglass Jul 2024 - Dec 2024 : Regulatory submission in EU for 1L myelofibrosis
Jan 2024 - Mar 2024: From MANIFEST-2 trial in combination with ruxolitinib as a first-line treatment for patients with myelofibrosis
Feb 2024 - Feb 2024: Completion of P2b trial for JIA
Feb 2024 - Feb 2024: Exclusivity expiry in US
Active, not recruiting
3
430
Europe, Canada, US, RoW
Pelabresib, Ruxolitinib, Placebo
Constellation Pharmaceuticals
Myelofibrosis, Primary Myelofibrosis, Post-polycythemia Vera Myelofibrosis, Post-essential Thrombocythemia Myelofibrosis
08/23
12/27
SURMOUNT-ADOLESCENTS-2, NCT06439277: A Study of Tirzepatide in Adolescents With Obesity and Weight-Related Comorbidities

Recruiting
3
300
Europe, Canada, US, RoW
Tirzepatide, LY3298176, Placebo
Eli Lilly and Company
Obesity, Weight Gain
05/27
06/27
Anderson, Joseph C
ACCIO, NCT04267848: Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-Small Cell Lung Cancer, ALCHEMIST Trial

Recruiting
3
1210
US, RoW
Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Carboplatin, Blastocarb, Carboplat, Carboplatin Hexal, Carboplatino, Carboplatinum, Carbosin, Carbosol, Carbotec, CBDCA, Displata, Ercar, JM-8, JM8, Nealorin, Novoplatinum, Paraplatin, Paraplatin AQ, Paraplatine, Platinwas, Ribocarbo, Cisplatin, Abiplatin, Blastolem, Briplatin, CDDP, Cis-diammine-dichloroplatinum, Cis-diamminedichloridoplatinum, Cis-diamminedichloro Platinum (II), Cis-diamminedichloroplatinum, Cis-dichloroammine Platinum (II), Cis-platinous Diamine Dichloride, Cis-platinum, Cis-platinum II, Cis-platinum II Diamine Dichloride, Cismaplat, Cisplatina, Cisplatinum, Cisplatyl, Citoplatino, Citosin, Cysplatyna, DDP, Lederplatin, Metaplatin, Neoplatin, Peyrone's Chloride, Peyrone's Salt, Placis, Plastistil, Platamine, Platiblastin, Platiblastin-S, Platinex, Platinol, Platinol- AQ, Platinol-AQ, Platinol-AQ VHA Plus, Platinoxan, Platinum, Platinum Diamminodichloride, Platiran, Platistin, Platosin, Computed Tomography, CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, Computerized Tomography (CT) scan, CT, CT Scan, tomography, Echocardiography, EC, Gemcitabine Hydrochloride, dFdCyd, Difluorodeoxycytidine Hydrochloride, Gemcitabine HCI, Gemzar, LY 188011, LY-188011, LY188011, Magnetic Resonance Imaging, Magnetic Resonance, Magnetic Resonance Imaging (MRI), Magnetic resonance imaging (procedure), Magnetic Resonance Imaging Scan, Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance, MR, MR Imaging, MRI, MRI Scan, MRIs, NMR Imaging, NMRI, Nuclear Magnetic Resonance Imaging, sMRI, Structural MRI, Observation, Inspection, Visual Inspection, Paclitaxel, Anzatax, Asotax, Bristaxol, Praxel, Taxol, Taxol Konzentrat, Pembrolizumab, BCD-201, GME 751, GME751, Keytruda, Lambrolizumab, MK 3475, MK-3475, MK3475, Pembrolizumab Biosimilar BCD-201, Pembrolizumab Biosimilar GME751, Pembrolizumab Biosimilar QL2107, Pembrolizumab Biosimilar RPH-075, QL2107, RPH 075, RPH-075, RPH075, SCH 900475, SCH-900475, SCH900475, Pemetrexed Disodium, Alimta, Almita, LY231514, N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid Disodium Salt, Questionnaire Administration
National Cancer Institute (NCI)
Lung Non-Small Cell Carcinoma, Lung Non-Small Cell Squamous Carcinoma, Lung Non-Squamous Non-Small Cell Carcinoma, Stage II Lung Cancer AJCC v8, Stage IIIA Lung Cancer AJCC v8, Stage IIIB Lung Cancer AJCC v8
12/25
12/25
ALCHEMIST, NCT02201992: Crizotinib in Treating Patients With Stage IB-IIIA Non-small Cell Lung Cancer That Has Been Removed by Surgery and ALK Fusion Mutations (An Treatment Trial)

Recruiting
3
168
US, RoW
Clinical Observation, Crizotinib, MET tyrosine kinase inhibitor PF-02341066, PF-02341066, PF-2341066, Xalkori, Laboratory Biomarker Analysis
ECOG-ACRIN Cancer Research Group, National Cancer Institute (NCI)
ALK Gene Rearrangement, ALK Gene Translocation, ALK Positive, Stage IB Non-Small Cell Lung Carcinoma AJCC v7, Stage II Non-Small Cell Lung Cancer AJCC v7, Stage IIA Non-Small Cell Lung Carcinoma AJCC v7, Stage IIB Non-Small Cell Lung Carcinoma AJCC v7, Stage IIIA Non-Small Cell Lung Cancer AJCC v7
05/36
05/36
ALCHEMIST Screening, NCT02194738: Genetic Testing in Screening Patients With Stage IB-IIIA Non-small Cell Lung Cancer That Has Been or Will Be Removed by Surgery (The Trial)

Recruiting
N/A
8300
US, RoW
Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Carboplatin, Blastocarb, Carboplat, Carboplatin Hexal, Carboplatino, Carboplatinum, Carbosin, Carbosol, Carbotec, CBDCA, Displata, Ercar, JM-8, JM8, Nealorin, Novoplatinum, Paraplatin, Paraplatin AQ, Paraplatine, Platinwas, Ribocarbo, Cisplatin, Abiplatin, Blastolem, Briplatin, CDDP, Cis-diammine-dichloroplatinum, Cis-diamminedichloridoplatinum, Cis-diamminedichloro Platinum (II), Cis-diamminedichloroplatinum, Cis-dichloroammine Platinum (II), Cis-platinous Diamine Dichloride, Cis-platinum, Cis-platinum II, Cis-platinum II Diamine Dichloride, Cismaplat, Cisplatina, Cisplatinum, Cisplatyl, Citoplatino, Citosin, Cysplatyna, DDP, Lederplatin, Metaplatin, Neoplatin, Peyrone's Chloride, Peyrone's Salt, Placis, Plastistil, Platamine, Platiblastin, Platiblastin-S, Platinex, Platinol, Platinol- AQ, Platinol-AQ, Platinol-AQ VHA Plus, Platinoxan, Platinum, Platinum Diamminodichloride, Platiran, Platistin, Platosin, Clinical Observation, observation, Computed Tomography, CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, Computerized Tomography (CT) scan, CT, CT Scan, tomography, Crizotinib, Alkixen, Crizocent, MET Tyrosine Kinase Inhibitor PF-02341066, PF 02341066, PF-02341066, PF-2341066, PF02341066, Xalkori, Cytology Specimen Collection Procedure, Cytologic Sampling, Echocardiography, EC, Erlotinib, Gemcitabine Hydrochloride, dFdCyd, Difluorodeoxycytidine Hydrochloride, Gemcitabine HCI, Gemzar, LY 188011, LY-188011, LY188011, Nivolumab, ABP 206, BCD-263, BMS 936558, BMS-936558, BMS936558, CMAB819, MDX 1106, MDX-1106, MDX1106, NIVO, Nivolumab Biosimilar ABP 206, Nivolumab Biosimilar BCD-263, Nivolumab Biosimilar CMAB819, ONO 4538, ONO-4538, ONO4538, Opdivo, Paclitaxel, Anzatax, Asotax, Bristaxol, Praxel, Taxol, Taxol Konzentrat, Pembrolizumab, BCD-201, GME 751, GME751, Keytruda, Lambrolizumab, MK 3475, MK-3475, MK3475, Pembrolizumab Biosimilar BCD-201, Pembrolizumab Biosimilar GME751, Pembrolizumab Biosimilar QL2107, Pembrolizumab Biosimilar RPH-075, QL2107, RPH 075, RPH-075, RPH075, SCH 900475, SCH-900475, SCH900475, Pemetrexed, MTA, Multitargeted Antifolate, Pemfexy, Pemetrexed Disodium, Alimta, Almita, LY231514, N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid Disodium Salt, Placebo Administration, Positron Emission Tomography, Medical Imaging, Positron Emission Tomography, PET, PET Scan, Positron emission tomography (procedure), Positron Emission Tomography Scan, Positron-Emission Tomography, proton magnetic resonance spectroscopic imaging, PT
National Cancer Institute (NCI)
Stage IB Lung Non-Small Cell Carcinoma AJCC v7, Stage II Lung Non-Small Cell Cancer AJCC v7, Stage IIA Lung Cancer AJCC v8, Stage IIB Lung Cancer AJCC v8, Stage IIIA Lung Cancer AJCC v8, Stage IIIA Lung Non-Small Cell Cancer AJCC v7, Stage IIIB Lung Cancer AJCC v8
09/26
09/26
Reichenberger, Ernst
NCT01630460: Genetic and Functional Analysis of Craniometaphyseal Dysplasia (CMD)

Recruiting
N/A
600
US
UConn Health
Craniometaphyseal Dysplasia
12/25
12/25
NCT01630447: Genetic and Functional Analysis of Cherubism

Recruiting
N/A
600
US
UConn Health
Cherubism
12/25
12/25
NCT01630421: Genetic and Functional Analysis of Aplasia Cutis Congenital (ACC)

Recruiting
N/A
600
US
UConn Health
Aplasia Cutis Congenita
12/25
12/25
NCT01619553: Genetic Analysis of Keloids

Recruiting
N/A
7000
US
UConn Health
Keloid
12/25
12/25
Fortinsky, Richard
NCT02938923: Starting a Testosterone and Exercise Program After Hip Injury

Completed
3
129
US
Testosterone, T, Placebo gel, P, Supervised exercise training, EX, Home exercise program, EUC, Health Education Modules
Washington University School of Medicine, University of Maryland, Baltimore, University of Colorado, Denver, The University of Texas Medical Branch, Galveston, Johns Hopkins University, Harvard University, University of Connecticut, University of Utah, University of Pittsburgh Medical Center
Hip Fracture, Frailty, Sarcopenia
08/23
11/23
NCT05080777: Pilot Pragmatic Clinical Trial to Embed Tele-Savvy Into Health Care Systems

Completed
N/A
76
US
Tele-Savvy, Caregiving During Crisis (Educational Program)
UConn Health, Emory University
Alzheimer Disease, Dementia, Brain Diseases, Central Nervous System Diseases, Nervous System Diseases, Tauopathies, Neurocognitive Disorders, Neurodegenerative Diseases, Mental Disorders
06/23
06/23
NCT02945085: 3D Team Care for Cognitively Vulnerable Older Adults

Completed
N/A
506
US
Home Based Care Team, Telephone Based Care Team
UConn Health, Patient-Centered Outcomes Research Institute, University of Connecticut
Dementia, Depression, Delirium
07/24
07/24
Moss, Isaac
NCT05929755: Depo-Medrol on Psoas After LLIF

Recruiting
4
80
US
Depo-Medrol, Gel-Flow NT
Hardeep Singh, Society for Minimally Invasive Spine Surgery
Muscle Weakness, Pain, Postoperative, Paresthesia, Pain, Muscle
08/25
05/27
Tannenbaum, Susan
PRESERVE-003, NCT05671510: ONC-392 Versus Docetaxel in Metastatic NSCLC That Progressed on PD-1/PD-L1 Inhibitors

Active, not recruiting
3
600
Europe, Canada, US, RoW
Gotistobart, A humanized anti-CTLA4 IgG1 monoclonal antibody, ONC-392, BNT316, Docetaxel, Docefrez, Taxotere
OncoC4, Inc., BioNTech SE
Non Small Cell Lung Cancer
06/26
06/27
PRESERVE-001, NCT04140526: Safety, PK and Efficacy of ONC-392 in Monotherapy and in Combination of Anti-PD-1 in Advanced Solid Tumors and NSCLC

Recruiting
1/2
733
US, RoW
ONC-392, A humanized anti-CTLA4 IgG1 monoclonal antibody made by OncoC4, Inc., Pembrolizumab, Keytruda, MK3475, Docetaxel, Taxotere, Docefrez
OncoC4, Inc., National Cancer Institute (NCI)
Non Small Cell Lung Cancer, Advanced Solid Tumor, Metastatic Melanoma, Metastatic Head and Neck Carcinoma, Metastatic Renal Cell Carcinoma, Metastatic Colorectal Cancer, Sarcomas, Metastatic Prostate Cancer, Ovarian Cancer, Small Cell Lung Cancer, Metastatic Breast Cancer, Pancreas Cancer, Gastric Cancer, Esophageal Cancer, Gastroesophageal Junction Adenocarcinoma, Cervical Cancer, Adenoid Cystic Carcinoma, Salivary Gland Cancer, Urothelial Carcinoma
06/26
12/27
Tennen, Howard
NCT05862870: TMD Online Program for Pain Management

Completed
N/A
21
US
painTRAINER
UConn Health, National Institute of Dental and Craniofacial Research (NIDCR)
TMD/Orofacial Pain
08/23
08/23
Callahan, Margaret
NCT02339571: A Phase II/III Trial of Nivolumab, Ipilimumab, and GM-CSF in Patients With Advanced Melanoma

Recruiting
2/3
600
US
Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Computed Tomography, CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, Computerized Tomography (CT) scan, CT, CT Scan, tomography, Echocardiography, EC, Ipilimumab, Anti-Cytotoxic T-Lymphocyte-Associated Antigen-4 Monoclonal Antibody, BMS 734016, BMS-734016, BMS734016, Ipilimumab Biosimilar CS1002, MDX 010, MDX-010, MDX-CTLA4, MDX010, Yervoy, Magnetic Resonance Elastography, MRE, Multigated Acquisition Scan, Blood Pool Scan, Equilibrium Radionuclide Angiography, Gated Blood Pool Imaging, Gated Heart Pool Scan, MUGA, MUGA Scan, Multi-Gated Acquisition Scan, Radionuclide Ventriculogram Scan, Radionuclide Ventriculography, RNV Scan, RNVG, SYMA Scanning, Synchronized Multigated Acquisition Scanning, Nivolumab, ABP 206, BCD-263, BMS 936558, BMS-936558, BMS936558, CMAB819, MDX 1106, MDX-1106, MDX1106, NIVO, Nivolumab Biosimilar ABP 206, Nivolumab Biosimilar BCD-263, Nivolumab Biosimilar CMAB819, ONO 4538, ONO-4538, ONO4538, Opdivo, Sargramostim, 23-L-Leucinecolony-Stimulating Factor 2, DRG-0012, Leukine, Prokine, rhu GM-CFS, Sagramostim, Sargramostatin
National Cancer Institute (NCI)
Stage III Cutaneous Melanoma AJCC v7, Stage IV Cutaneous Melanoma AJCC v6 and v7
06/33
06/33
CA209-260, NCT02553642: Relationship Between Tumor Mutation Burden and Predicted Neo-antigen Burden in Patients With Advanced Melanoma or Bladder Cancer Treated With Nivolumab or Nivolumab Plus Ipilimumab

Completed
2
81
US
Nivolumab, Nivolumab plus Ipilimumab
Memorial Sloan Kettering Cancer Center, UConn Health, Bristol-Myers Squibb, Adaptive Biotechnologies, MedGenome
Bladder Cancer, Melanoma
04/24
04/24
NCT05060003: Tiragolumab Plus Atezolizumab Versus Atezolizumab in the Treatment of Stage II Melanoma Patients Who Are ctDNA-positive Following Resection

Terminated
2
7
US
Atezolizumab, Tecentriq, Tiragolumab, Signatera Assay
Washington University School of Medicine, Genentech, Inc.
Stage II Melanoma
11/23
11/23
IMC-F106C-101, NCT04262466 / 2019-004046-16: Safety and Efficacy of IMC-F106C as a Single Agent and in Combination With Checkpoint Inhibitors

Hourglass Oct 2024 - Dec 2024 : Data for late-line NSCLC
Recruiting
1/2
727
Europe, Canada, US, RoW
Brenetafusp, Brenetafusp and pembrolizumab, Brenetafusp and chemotherapy, Brenetafusp and monoclonal antibodies and chemotherapy, Brenetafusp and tebentafusp, Brenetafusp and bevacizumab, Brenetafusp and kinase inhibitors
Immunocore Ltd
Select Advanced Solid Tumors
02/26
08/26
ELU-FRα-1, NCT05001282: A Study to Evaluate ELU001 in Patients With Solid Tumors That Overexpress Folate Receptor Alpha (FRα)

Terminated
1/2
79
US
ELU001, FA-CDC
Elucida Oncology
Ovarian Cancer, Ovarian Neoplasms, Ovarian Carcinoma, Endometrial Cancer, Ovary Cancer, Ovary Neoplasm, Ovary Disease, Ovary Metastasis, Ovarian Diseases, Ovarian Cancer Stage, Ovarian Epithelial Cancer, Ovarian Adenocarcinoma, Ovarian Serous Adenocarcinoma, Ovarian Neoplasm Epithelial, Ovarian Cancer Recurrent, Endometrial Diseases, Endometrial Adenocarcinoma, Endometrial Carcinosarcoma, Endometrial Clear Cell Adenocarcinoma, Endometrioid Adenocarcinoma, Endometrial Neoplasms, Endometrial Cancer Recurrent, Endometrioid Tumor, Fallopian Tube Cancer, Peritoneal Cancer
06/24
06/24
GLIMMER-01, NCT05259696: Glycan Mediated Immune Regulation With a Bi-Sialidase Fusion Protein

Active, not recruiting
1/2
273
US
E-602, Cemiplimab, Libtayo, REGN2810
Palleon Pharmaceuticals, Inc.
Oncology, Melanoma, Ovarian Cancer, NSCLC, Non Small Cell Lung Cancer, Colorectal Cancer, Pancreatic Cancer, Cancer, CRC, Colon Cancer, Breast Cancer, Gastric Cancer, EGJ, Esophagogastric Junction Cancer, Head and Neck Cancer, Urothelial Cancer, Bladder Cancer
06/25
06/25
Kamath, Jayesh
DepWatch, NCT06292221: Personalized Depression Treatment Supported by Mobile Sensor Analytics

Recruiting
N/A
128
US
A mobile Health (mHealth) tool called 'DepWatch'
UConn Health, National Institute of Mental Health (NIMH)
Depression
04/25
06/25
Tennent, David J
OASIS, NCT04809064: Open Versus Arthroscopic Stabilization of Shoulder Instability with Subcritical Bone Loss: the Trial

Recruiting
N/A
400
US
Arthroscopic Bankart repair procedure, Open Bankart, Latarjet, Post-Operative Rehabilitation
University of Pittsburgh, Walter Reed National Military Medical Center
Shoulder Dislocation, Glenohumeral Dislocation, Anterior Shoulder Dislocation
09/27
09/27
Lindsay, Adam
SAFETY, NCT03944798: Surveillance AFter Extremity Tumor surgerY

Active, not recruiting
N/A
310
Europe, Canada, US, RoW
Frequency: Every 3 Months, Frequency: Every 6 Months, Imaging Modality: Chest Radiograph (CXR), Imaging Modality: Chest CT
McMaster University, Hamilton Academic Health Sciences Organization, Canadian Cancer Society (CCS), Canadian Institutes of Health Research (CIHR), American Academy of Orthopaedic Surgeons, Musculoskeletal Tumor Society
Soft Tissue Sarcoma, Lung Metastases
12/27
12/27
Andemariam, Biree
THRIVE-131, NCT04935879: A Study to Assess the Safety and Efficacy of Inclacumab in Participants With Sickle Cell Disease Experiencing Vaso-occlusive Crises

Completed
3
243
Europe, US, RoW
Inclacumab, Placebo
Pfizer
Sickle Cell Disease, Vaso-occlusive Pain Episode in Sickle Cell Disease, Vaso-occlusive Crisis
06/24
06/24
NCT02306993: Sickle Cell Hemoglobinopathies and Bone Health

Active, not recruiting
N/A
45
US
Healthy volunteers without SCT, Healthy volunteers with SCT, Volunteers with SCD
UConn Health
Sickle Cell Disease, Sickle Cell Trait
12/25
12/25
NCT06743113: Hypoxic Red Blood Cells in Sickle Cell Anemia

Not yet recruiting
N/A
48
US
Hemanext ONE System, Conventional RBCs
Hemanext, Emory University, University of Connecticut, University of Pittsburgh Medical Center, Johns Hopkins All Children's Hospital, Johns Hopkins University
Sickle Cell Anaemia, Sickle Cell Anemia Crisis, Sickle Cell Anemia in Children, Sickle Cell Anemia (HbSS, or HbSβ-thalassemia0)
02/28
06/28
PROSPECT, NCT04930445: Oxbryta® Product Registry An Observational Study Designed to Evaluate the Effect of Oxbryta in Individuals With SCD

Terminated
N/A
262
US
Oxbryta® (voxelotor) 500mg Tablets, Voxelotor, Oxbryta®
Pfizer, Pfizer
Sickle Cell Disease
10/24
10/24
Vaziri, Haleh
NCT05195970: Walnuts and Colon Health

Recruiting
N/A
200
US
Walnuts
UConn Health, National Institutes of Health (NIH), National Cancer Institute (NCI), Weill Medical College of Cornell University, University of Connecticut, California Walnut Commission, Spanish National Research Council, University of Florida
Colorectal Cancer, Diet Habit
12/25
12/26
BIRK, JOHN
NCT05195970: Walnuts and Colon Health

Recruiting
N/A
200
US
Walnuts
UConn Health, National Institutes of Health (NIH), National Cancer Institute (NCI), Weill Medical College of Cornell University, University of Connecticut, California Walnut Commission, Spanish National Research Council, University of Florida
Colorectal Cancer, Diet Habit
12/25
12/26
Ioannidou, Effie
NCT03241511: Novel PAradigm to Improve Inflammatory Burden in ESRD (rePAIR): A Pilot and Feasibility Randomized Controlled Trial

Active, not recruiting
N/A
90
US
Test
UConn Health, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Chronic Periodontitis, End Stage Renal Disease
04/21
04/21
Fetter, Ruth
NCT03959826: Promoting Employment in Persons Living With HIV/AIDS

Recruiting
N/A
144
US
activity contracting, contingency management for activity completion
UConn Health, National Institute on Drug Abuse (NIDA)
Unemployment, HIV
01/25
01/25
NCT03768986: A Reinforcement Intervention for Increasing HIV Testing Among At-Risk Women

Active, not recruiting
N/A
334
US
Standard referral for HIV testing, Online risk reduction training, Reinforcement
UConn Health, National Institute on Minority Health and Health Disparities (NIMHD)
HIV, HIV Testing, Women, Contingency Management
12/24
12/24
Peth, NCT04064463: Dual Reinforcement Contingency Management for Alcohol Use Disorders

Recruiting
N/A
150
US
Standard care, Contingency management
UConn Health, National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Alcohol Use Disorder, Contingency Management
05/25
05/25
P2P, NCT05374395: Enhancing Substance Use Treatment Services to Decrease Dropout and Improve Outpatient Treatment Utilization in Emerging Adults

Active, not recruiting
N/A
11
US
Peer Recovery Support-Delivered Dropout Prevention enhancement
UConn Health, Oregon Social Learning Center, University of Texas at Austin
Substance Use Disorders
10/26
02/27
O'Sullivan, Michael B
STAREE-Mind, NCT05586750: Statins in Reducing Events in the Elderly Mind () Imaging Substudy

Active, not recruiting
4
341
RoW
Atorvastatin 40 Mg Oral Tablet, Placebo
Monash University, National Health and Medical Research Council, Australia
Dementia, Mixed, Dementia, Vascular, Dementia of Alzheimer Type, Cognitive Decline, White Matter Hyperintensity, Aging, Neuro-Degenerative Disease
09/26
09/26
adored, NCT05003804: Allergic Disease Onset Prevention Study

Active, not recruiting
1/2
264
US, RoW
STMC-103H, Placebo
Siolta Therapeutics, Inc.
Atopic Dermatitis, Type 1 Hypersensitivity
11/24
10/25
NCT06148051: AusCADASIL: An Australian Cohort of CADASIL

Recruiting
N/A
300
RoW
Perminder Sachdev, Prince of Wales Hospital, Sydney, John Hunter Hospital, St Vincent's Hospital - Sydney, Australia, Royal Brisbane and Women's Hospital, Melbourne Health, The University of Queensland
Cadasil
03/27
03/27
ROSENBERG, DANIEL W
NCT05195970: Walnuts and Colon Health

Recruiting
N/A
200
US
Walnuts
UConn Health, National Institutes of Health (NIH), National Cancer Institute (NCI), Weill Medical College of Cornell University, University of Connecticut, California Walnut Commission, Spanish National Research Council, University of Florida
Colorectal Cancer, Diet Habit
12/25
12/26
Surita, Rao
NCT04098302: Dutasteride Treatment for Reducing Heavy Drinking in AUD: Predictors of Efficacy

Completed
2/3
180
US
Dutasteride Capsules, Avodart, Placebo Capsules, inactive placebo
UConn Health, National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Alcohol Use Disorder
06/24
06/24
Howard, Tennen
NCT04098302: Dutasteride Treatment for Reducing Heavy Drinking in AUD: Predictors of Efficacy

Completed
2/3
180
US
Dutasteride Capsules, Avodart, Placebo Capsules, inactive placebo
UConn Health, National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Alcohol Use Disorder
06/24
06/24
Jonathan, Covault
NCT04098302: Dutasteride Treatment for Reducing Heavy Drinking in AUD: Predictors of Efficacy

Completed
2/3
180
US
Dutasteride Capsules, Avodart, Placebo Capsules, inactive placebo
UConn Health, National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Alcohol Use Disorder
06/24
06/24
DiMauro, Sharon
NCT04321512: Study of Circulating Monocytes in Patients With Ischemic Vascular Disease

Recruiting
N/A
300
US
There is no intervention given to the subjects
UConn Health
Myocardial Infarction, Stroke, Ischemic, Ischemia
02/25
02/25
Edgar, Cory M
OASIS, NCT04809064: Open Versus Arthroscopic Stabilization of Shoulder Instability with Subcritical Bone Loss: the Trial

Recruiting
N/A
400
US
Arthroscopic Bankart repair procedure, Open Bankart, Latarjet, Post-Operative Rehabilitation
University of Pittsburgh, Walter Reed National Military Medical Center
Shoulder Dislocation, Glenohumeral Dislocation, Anterior Shoulder Dislocation
09/27
09/27
Burland, Julie
NCT05617911: Clinical Comparison of Patellofemoral Pain Syndrome Outcomes After Blood Flow Restriction Therapy

Terminated
N/A
1
US
Blood Flow Restriction Cuff, Sham and standard of Care Therapy
Gaylord Hospital, Inc, UConn Health
Patellofemoral Pain Syndrome, Anterior Knee Pain Syndrome
10/23
10/23
Izydorczak, Michelle
NCT04321512: Study of Circulating Monocytes in Patients With Ischemic Vascular Disease

Recruiting
N/A
300
US
There is no intervention given to the subjects
UConn Health
Myocardial Infarction, Stroke, Ischemic, Ischemia
02/25
02/25

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