The Sixth Affiliated Hospital, Sun Yat-sen University
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 88 Trials 
819 Trials

   

Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Li, Hong
REPOSE-2, NCT05728775: REmimazolam vs Propofol Total Intravenous Anesthesia on Outcomes After Major Noncardiac SurgEry

Recruiting
4
7188
RoW
Remimazolam, Propofol
Nanfang Hospital of Southern Medical University
Anesthesia, Surgery-Complications
12/24
12/27
NCT05182463: Peginterferon Treatment Study for Inactive Chronic Hepatitis B Patients

Recruiting
4
5000
RoW
Peginterferon Alfa-2B, Nucleoside Analogs
Third Affiliated Hospital, Sun Yat-Sen University
Hepatitis B, Chronic
12/26
11/29
NATiV3, NCT04849728: A Phase 3 Study Evaluating Efficacy and Safety of Lanifibranor Followed by an Active Treatment Extension in Adult Patients With (NASH) and Fibrosis Stages F2 and F3 ( )

Recruiting
3
1000
Europe, Canada, US, RoW
IVA337, Lanifibranor, Placebo
Inventiva Pharma
NASH - Nonalcoholic Steatohepatitis
09/25
09/26
FOCUS-C, NCT05334277: Furmonertinib Monotherapy and Combination Therapy in Advanced EGFR Mutant NSCLC With Uncleared ctDNA

Recruiting
2
280
RoW
Furmonertinib, AST2818, Furmonertinib/Pemetrexed/Carboplatin, Furmonertinib/Pemetrexed/Carboplatin/Bevacizumab
Sun Yat-sen University, Allist Pharmaceuticals, Inc., GeneCast Biotechnology Co., Ltd.
Non-small Cell Lung Cancer
02/25
02/28
POEM, NCT04219033: Postoperative Cognitive Function and EEG

Recruiting
N/A
1250
RoW
EEG(Electroencephalogram) change
Air Force Military Medical University, China
Aging, Postoperative Cognitive Dysfunction, EEG With Periodic Abnormalities
03/23
04/23
NCT06308627: A One-year Trajectory of Depression Status Changes in Older Adults With MCI and SD: a Longitudinal Cohort Study

Completed
N/A
466
RoW
Fujian Medical University
Mild Cognitive Impairment, Subthreshold Depression, Older Adults
08/24
08/24
NCT05521295: Frozen Embryo Transfer Pregnancy Outcomes Prediction by Microbiome

Recruiting
N/A
3600
RoW
no intervention
Shengjing Hospital, Beijing Institutes of Life Science, Chinese Academy of Sciences
Infertility, Microbiome
09/23
09/24
REMAIN-2, NCT05962125: The Role of Periodic Alveolar Recruitment Maneuvers in Intraoperative Protective Ventilation

Completed
N/A
75
RoW
periodic alveolar recruitment maneuvers, positive end-expiratory pressure
Sixth Affiliated Hospital, Sun Yat-sen University
Mechanical Power, Alveolar Recruitment Maneuvers, Protective Ventilation, Postoperative Pulmonary Complications
11/23
12/23
NCT05442125: First Live Birth Rate With eSET After Preimplantation Methylome Screening (PIMS) Versus Conventional In-vitro Fertilization

Recruiting
N/A
1146
RoW
Using DNA methylome to select embryos, Using morphologic score to select embryos
Shandong University, RenJi Hospital, Reproductive & Genetic Hospital of CITIC-Xiangya, Nanjing Maternity and Child Health Care Hospital, ShangHai Ji Ai Genetics & IVF Institute, Suzhou Municipal Hospital, The First Hospital of Jilin University, Sir Run Run Shaw Hospital, The Affiliated Hospital Of Guizhou Medical University, The Second Hospital of Hebei Medical University, Third Affiliated Hospital of Zhengzhou University, Ruijin Hospital, International Peace Maternity and Child Health Hospital, Henan Provincial People's Hospital, The First Affiliated Hospital of Hainan Medical University, The First Affiliated Hospital of Anhui Medical University, Fujian Maternity and Child Health Hospital, General Hospital of Ningxia Medical University, The First Affiliated Hospital with Nanjing Medical University, 900 th Hospital of Joint Logistics Support Force, Guangzhou Womenand Children's Medical Center, Changhai Hospital, Shenzhen Maternity & Child Healthcare Hospital, Sixth Affiliated Hospital, Sun Yat-sen University, Liuzhou Hospital of Guangzhou Women and Children's Medical Center, Jining Medical University, Siriraj hospital, Mahidol university, Thailand
Reproductive Techniques, Assisted, DNA Methylation
06/24
05/25
NDURE2, NCT04030130: Navigation vs Usual Care for Timely Adjuvant Therapy for Patients With Locally Advanced HNSCC

Completed
N/A
176
US
NDURE
Medical University of South Carolina, National Cancer Institute (NCI)
Squamous Cell Carcinoma of Head and Neck
12/23
01/24
NCT06706739: A Trial of Combined Subthreshold Depression in Older Adults With Mild Cognitive Impairment Participating in Art Games

Recruiting
N/A
80
RoW
Online art game intervention group
Fujian Medical University
Mild Cognitive Impairment, Subthreshold Depression
12/24
12/24
REMAIN-1, NCT05556174: Intraoperative Lung Protective Ventilation Needs Periodic Lung Recruitment Maneuvers

Completed
N/A
1060
RoW
periodic lung recruitment maneuvers
Sixth Affiliated Hospital, Sun Yat-sen University
Postoperative Complications, Abdominal Surgery, Intraoperative Mechanical Ventilation
09/24
11/24
NCT04989153: Nasal Endoscopic Screening and Risk Assessment for Early Gastric Cancer

Recruiting
N/A
5000
RoW
pepsinogen
Second Affiliated Hospital, School of Medicine, Zhejiang University, Jilin City People's Hospital, No. 924 Hospital of the People's Liberation Army of China, Kunshan Hospital of Traditional Chinese Medicine, Chinese PLA General Hospital, Sichuan Provincial People's Hospital, Affiliated Hospital of Southwest Medical University, Zhongshan Hospital Xiamen University, Jingzhou Hospital of Traditional Chinese Medicine, Changhai Hospital
Gastric Cancer, Precancerous Lesion, Helicobacter Pylori Infection
12/22
12/23
Lan, Ping
NCT02087475: Perioperative FOLFIRI VS Adjuvant FOLFIRI in Resectable Advanced CRC Failed to Oxaliplatin

Recruiting
3
360
RoW
Irinotecan, 5-fluorouracil, Local radiotherapy, R0 resection
Sixth Affiliated Hospital, Sun Yat-sen University
Colorectal Neoplasms, Effects of Chemotherapy, Surgery, Metastasis, Local Neoplasm Recurrence
12/21
12/24
NCT03975049: Triplet Combination or Doublet Regimen Versus Chemoradiation as Neoadjuvant Therapy for Locally Advanced Rectal Cancer

Not yet recruiting
3
933
NA
Chemoradiation, FOLFOXIRI Protocol, Folfox Protocol
Sixth Affiliated Hospital, Sun Yat-sen University
Rectal Cancer, Chemotherapy Effect
07/24
07/29
PROMOTE, NCT03928652: Prognostic Biomarker for CRC

Recruiting
N/A
1050
RoW
Sixth Affiliated Hospital, Sun Yat-sen University
Colorectal Cancer
04/23
12/23
NCT03411707: Multiple Screening Methods for the Detection of Chinese Colorectal Advanced Adenomatous Polyps and Cancer

Recruiting
N/A
1200
RoW
Stool DNA test, Blood mRNA test, FIT Assay
Sixth Affiliated Hospital, Sun Yat-sen University, Changhai Hospital, Tianjin Nankai Hospital
Colorectal Cancer, Colorectal Adenomatous Polyp
06/23
06/23
NCT04947930: Fecal Metagenomics and Metabolomics Analyses to Identify Potential Screening Biomarkers for Colorectal Polyps and Cancer in Chinese Population

Not yet recruiting
N/A
600
RoW
Sixth Affiliated Hospital, Sun Yat-sen University
Colorectal Cancer, Colorectal Polyp, Mass Screening, Gastrointestinal Microbiome
07/22
07/23
Xie, Hao
KN-8701, NCT04913285: A Study to Evaluate KIN-2787 in Participants With BRAF and/or NRAS Mutation Positive Solid Tumors

Recruiting
1
400
Europe, US, RoW
KIN-2787, exarafenib, KIN-2787 and binimetinib, exarafenib and binimetinib
Pierre Fabre Medicament
Solid Tumor, Adult, Non-small Cell Lung Cancer, Melanoma
12/24
12/25
SPX-303, NCT06259552: A Study of , a Bispecific Antibody Targeting LILRB2 and PD-L1 in Patients With Solid Tumors

Recruiting
1
232
US
SPX- 303 Injection, a bispecific anti-LILRB2 / anti-PD-L1 Antibody, SPX-303
SparX Biotech(Jiangsu) Co., Ltd.
Solid Tumor, HNSCC, RCC, CRC
09/27
09/27
NCT06607185: A Study of the Pan-KRAS Inhibitor LY4066434 in Participants With KRAS Mutant Solid Tumors

Recruiting
1
750
Europe, Japan, US, RoW
LY4066434., Cetuximab, Nab paclitaxel, Gemcitabine, Oxaliplatin, Leucovorin, Irinotecan, 5Fluorouracil, Carboplatin, Cisplatin, Pemetrexed, Pembrolizumab
Eli Lilly and Company
Pancreatic Ductal Adenocarcinoma, Non-small Cell Lung Cancer, Colorectal Cancer, Advanced Solid Tumor, Metastatic Solid Tumor
01/30
01/30
GIHSYSU-36, NCT06485609: Clinical Study of Radical Right Hemicolectomy Versus Radical Right Hemicolectomy Combined with Indocyanine Green Fluorescence Imaging Lymphatic Tracer Dissection for the Treatment of Right Colon Cancer

Recruiting
N/A
1200
RoW
radical right hemicolectomy combined with indocyanine green fluorescence imaging lymphatic tracer dissection
Sun Yat-sen University
Colon Cancer
06/27
07/31
NCT05189171: MicroOrganoSphere (MOS) Drug Screen Pilot Trial in Colorectal Cancer

Completed
N/A
46
US
MicroOrganoSphere (MOS) drug screen
Xilis, Inc.
Colorectal Neoplasms
11/23
03/24
Deng, Yanhong
OPTICAL, NCT02572141: FOLFOX or CAPOX Perioperative Chemotherapy Versus Postoperative Chemotherapy for Locally Advanced Colon Cancer

Active, not recruiting
3
738
RoW
Perioperative chemotherapy with mFOLFOX6 or CAPOX regimens, Oxaliplatin, 5-Fluorouracil, Capecitabine, Leucovorin, Postoperative chemotherapy with mFOLFOX6 or CAPOX regimens
Sun Yat-sen University
Colon Cancer
04/21
04/23
NCT04714190: A Study of RC48-ADC in Local Advanced or Metastatic Gastric Cancer With the HER2-Overexpression

Recruiting
3
351
RoW
RC48-ADC, Recombinant Humanized anti-HER2 Monoclonal Antibody-MMAE Conjugate For Injection, Paclitaxel injection, Taxol, Irinotecan Hydrochloride Injection, CAMPTO, Apatinib Mesylate Tablets, Aitan
RemeGen Co., Ltd.
Gastric Cancer, HER2 Overexpressing Gastric Carcinoma
12/24
06/25
NCT04385550: A Study of Anlotinib Hydrochloride Capsule Combined With AK105 Injection in Subject With Advanced Gastric and Gastro-oesophageal Junction Adenocarcinoma

Not yet recruiting
3
528
RoW
Anlotinib hydrochloride capsule, AK105 injection, Paclitaxel injection, Docetaxel injection
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Advanced Gastric and Gastro-oesophageal Junction Adenocarcinoma
10/23
12/23
TRIBE-C, NCT04230187: Bevacizumab Plus MFOLFOXIRI As First-line Treatment for Patients with Unresectable Metastatic Colorectal Cancer

Active, not recruiting
3
528
RoW
mFOLFOXIRI plus Bevacizumab, Oxaliplatin, Irinotecan, 5-Fluorouracil, Leucovorin, Bevacizumab, mFOLFOX6 Plus Bevacizumab
Yanhong Deng
Colorectal Cancer
01/24
06/26
HERIZON-GEA-01, NCT05152147 / 2021-000296-36: A Study of Zanidatamab in Combination With Chemotherapy Plus or Minus Tislelizumab in Patients With HER2-positive Advanced or Metastatic Gastric and Esophageal Cancers

Recruiting
3
918
Europe, Canada, Japan, RoW
Zanidatamab, ZW25, JZP598, Tislelizumab, Trastuzumab, Herceptin®, Capecitabine, Oxaliplatin, Cisplatin, 5-Fluorouracil
Jazz Pharmaceuticals, BeiGene, Ltd.
Gastric Neoplasms, Gastroesophageal Adenocarcinoma, Esophageal Adenocarcinoma
05/25
05/26
FOBEAR, NCT04215731: Neoadjuvant mFOLFOXIRI Plus Bevacizumab in Patients With High-Risk Locally Advanced Rectal Cancer

Recruiting
3
500
RoW
Neoadjuvant chemotherapy with mFOLFOXIRI plus bevacizumab, Oxaliplatin, Irinotecan, 5-Fluorouracil, Leucovorin, Bevacizumab, Restaging, Concomitant Chemoradiotherapy, Surgery, Chemoradiotherapy (only when patients with MRF involved or ycT4a/b by restaging), Induction chemotherpay with FOLFOX
Yanhong Deng
Rectal Cancer
02/26
02/26
FANTASTIC, NCT04338191: mFOLFOXIRI Versus mFOLFOX6 as Adjuvant Chemotherapy for Locally Advanced Colorectal Cancer

Recruiting
3
638
RoW
mFOLFOXIRI adjuvant chemotherapy, Oxaliplatin, Irinotecan, Leucovorin, 5-Fluorouracil, mFOLFOX6 adjuvant chemotherapy
Sun Yat-sen University
Colorectal Cancer
02/25
02/25
AFFORD, NCT05427669: Adjuvant mFOLFOXIRI vs. mFOLFOX6 in MRD Positive Stage II-III Colorectal Cancer

Not yet recruiting
3
340
NA
mFOLFOXIRI, Oxaliplatin, Irinotecan, 5-Fluorouracil, Leucovorin, mFOLFOX6
Yanhong Deng
Colorectal Cancer
07/25
07/27
MOUNTAINEER-03, NCT05253651 / 2021-002672-40: A Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in First-line HER2+ Metastatic Colorectal Cancer

Recruiting
3
400
Europe, Canada, Japan, US, RoW
tucatinib, TUKYSA, ONT-380, ARRY-380, PF-07265792, trastuzumab, Herceptin, bevacizumab, Avastin, cetuximab, Erbitux, oxaliplatin, leucovorin, levoleucovorin, fluorouracil
Seagen Inc., Merck Sharp & Dohme LLC
Colorectal Neoplasms
08/25
04/28
AZUR-2, NCT05855200: Study of Perioperative Dostarlimab in Participants With Untreated T4N0 or Stage III dMMR/MSI-H Resectable Colon Cancer

Recruiting
3
711
Europe, Canada, Japan, US, RoW
Dostarlimab, CAPEOX, FOLFOX
GlaxoSmithKline
Colonic Neoplasms, Neoplasms, Colon
12/28
12/30
NCT05019794: Infigratinib in Subjects With GC or GEJ With FGFR2 Amplification or Other Solid Tumors With Other FGFR Alterations

Checkmark NMPA cleared CTA to conduct the Phase 2a trial for metastatic gastric cancer or GE junction adenocarcinoma with FGFR2 gene amplification
Dec 2020 - Dec 2020: NMPA cleared CTA to conduct the Phase 2a trial for metastatic gastric cancer or GE junction adenocarcinoma with FGFR2 gene amplification
Recruiting
2a
80
RoW
Infigratinib, BGJ398
LianBio LLC
Gastric Cancer, Gastroesophageal Junction Adenocarcinoma, Solid Tumor
12/22
12/23
NCT05130021: A Clincal Study of Max-40279-01 in Patients With Advanced Colorectal Cancer

Not yet recruiting
2
130
RoW
MAX-40279-01, regorafenib
Maxinovel Pty., Ltd.
Metastatic Colorectal Cancer
05/22
10/23
PCOX, NCT03638297: PD-1 Antibody Combined With COX Inhibitor in MSI-H/dMMR or High TMB Colorectal Cancer

Recruiting
2
29
RoW
PD-1 antibody + cox inhibitor
Sun Yat-sen University
Colorectal Cancer
08/22
08/25
NCT04603040: A Study to Evaluate the Efficacy and Safety of Toripalimab Injection in the Treatment of Recurrent or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma Who Have Failed at Least Two Prior Lines of Therapy and Are Positive Specific Markers

Recruiting
2
100
RoW
Toripalimab, Tuoyi
Shanghai Junshi Bioscience Co., Ltd.
Recurrent or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma Who Have Failed at Least Two Prior Lines of Therapy
12/22
03/23
NCT04030260: Regorafenib and PD-1 Antibody in Combination With Radiotherapy for pMMR/MSS Metastatic Colorectal Cancer

Recruiting
2
28
RoW
Regorafenib and PD-1 antibody in Combination with Radiotherapy, Regorafenib, PD-1 antibody, Radiation therapy
Sun Yat-sen University
Colorectal Cancer Metastatic, MSS
02/23
07/23
PICC, NCT03926338: Toripalimab With or Without Celecoxib as Neoadjuvant Therapy in Resectable dMMR/MSI-H Colorectal Cancer

Recruiting
2
150
RoW
Cohort 1: Neoadjuvant treatment with toripalimab plus celecoxib for 3 months, Toripalimab, Celecoxib, Cohort 1: Neoadjuvant treatment with toripalimab monotherapy for 3 months, Cohort 2: Neoadjuvant treatment with toripalimab plus celecoxib for 6 months, Cohort 2: Neoadjuvant treatment with toripalimab monotherapy for 6 months
Sun Yat-sen University
Colorectal Cancer, Mismatch Repair-deficient (dMMR), Microsatellite Instability-high (MSI-H), Neoadjuvant Therapy
04/27
04/30
NCT05148195: A Phase II Study of Envofolimab and BD0801 With/Without Chemotherapy in Patients With Advanced Solid Tumors

Terminated
2
86
RoW
Envofolimab, BD0801, Docetaxel, Irinotecan, Leucovorin calcium, 5-Fluorouridine
Jiangsu Simcere Pharmaceutical Co., Ltd.
Advanced Solid Tumor
07/23
07/23
NCT06206278: Evaluation of Infigratinib in Patients With Locally Advanced or Metastatic Gastric Cancer or GEJ Adenocarcinoma

Terminated
2
6
RoW
Infigratinib, BGJ398, BBP-831
LianBio LLC
Gastric Cancer, Gastroesophageal Junction Adenocarcinoma
05/24
05/24
NCT05068206: A Clinical Study to Compare the Efficacy and Safety of AK105 Plus Anlotinib and Capecitabine/Oxaliplatin (CapeOx) , Anlotinib Plus CapeOx, Bevacizumab Plus CapeOx

Recruiting
2
120
RoW
AK105 injection, Anlotinib hydrochloride capsule, CapeOX, Bevacizumab
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Unresectable Metastatic Colorectal Cancer
12/23
06/24
NAUTICALCRC, NCT05004350: A Study Evaluating the Combination of Encorafenib and Cetuximab Versus Irinotecan/Cetuximab or Infusional 5-fluorouracil (5-FU)/Folinic Acid (FA)/Irinotecan (FOLFIRI)/Cetuximab in Chinese Patients With BRAF V600E Mutant Metastatic Colorectal Cancer.

Active, not recruiting
2
103
RoW
Encorafenib, Braftovi®, PF-07263896, W0090, LGX818, ONO-7702, Cetuximab, Erbitux®, C225, FOLFIRI, Folinic acid + Fluorouracil + Irinotecan
Pierre Fabre Medicament, Merck KGaA, Darmstadt, Germany
BRAF V600E, Metastatic Colorectal Cancer
12/23
01/25
NCT03941574: A Clinical Study to Evaluate HLX10 Monotherapy for the Treatment of MSI-H or dMMR Solid Tumors That Failed to Respond to Standard Therapy

Recruiting
2
108
RoW
HLX10
Shanghai Henlius Biotech
MSI-H Solid Malignant Tumor
05/24
06/26
SINCERE, NCT05933980: Toripalimab,Celecoxib and Regorafenib in the Treatment of Refractory Advanced Colorectal Cancer

Recruiting
2
44
RoW
Rego+Tori+Cele, Bayer AG, Innovent Biologics
Sun Yat-sen University
Colorectal Cancer, Liver Metastases, MSS
09/25
12/25
China AZUR-1, NCT06640049: A Study of Dostarlimab in Participants With Untreated Locally Advanced Rectal Cancer in China

Recruiting
2
23
RoW
Dostarlimab, GSK4057190A, TSR-042
GlaxoSmithKline
Neoplasms, Rectal
12/28
03/31
NCT05472948: Surufatinib and Sintilimab in Combination With Capecitabine for Metastatic Adenocarcinoma of Small Intestine or Appendix Carcinoma

Recruiting
2
36
RoW
Surufatinib, SULANDA, Sintilimab, IBI308, Capecitabine, Capecitabine tablets
Sun Yat-sen University
Adenocarcinoma of Small Intestine, Appendix Carcinoma, Metastatic
11/24
11/25
CAMCO2, NCT05360277: Maintenance Tislelizumab + Capecitabine to Treat Metastatic Colorectal Cancer

Recruiting
2
52
RoW
Tislelizumab + Capecitabine, Best supportive care
Yanhong Deng
Metastatic Colorectal Cancer,NED
02/25
11/27
OPTICAL-2, NCT05571644: Neoadjuvant Treatment With mFOLFOXIRI Plus Cadonilimab (AK104) Versus mFOLFOX6 in Locally Advanced Colorectal Cancer

Recruiting
2
143
RoW
mFOLFOXIRI + Cadonilimab, Oxaliplatin, Irinotecan, 5-Fluorouracil, Leucovorin, Cadonilimab (AK104), mFOLFOX6, mFOLFOXIRI
Sun Yat-sen University
Colorectal Cancer
12/24
12/25
DETECT, NCT05578287: RC48 Plus Tislelizumab, Low-dose Capecitabine and Celecoxib for HER2-positive Metastatic Colorectal Cancer

Recruiting
2
29
RoW
Anti-HER2 ADC, Disitamab Vedotin, Tislelizumab, Capecitabin, Celecoxib
Sun Yat-sen University
Colorectal Cancer
12/24
12/25
NCT05934331: A LM-302 Combined With Toripalimab Phase II Study

Recruiting
2
276
RoW
LM302+Toripalimab, LM302+JS001
LaNova Medicines Zhejiang Co., Ltd.
Gastric Cancer, Pancreatic Cancer
07/25
01/26
CEIL, NCT05959356: Cetuximab and Envafolimab Plus mFOLFOXIRI as First-line Treatment for RAS/BRAF Wild-type, MSS, Unresectable Left-side Metastatic Colorectal Cancer

Recruiting
2
198
RoW
Cetuximab + Envafolimab + mFOLFOXIRI, Cetuximab or c225, Envafolimab, Irinotecan, Oxaliplatin, Leucovorin, 5-FU, Cetuximab + mFOLFOX6/FOLFIRI
Sun Yat-sen University
Metastatic Colorectal Cancer
12/25
12/27
TranStar102, NCT04495296: A Trial to Evaluate Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of TST001 in Advanced or Metastatic Solid Tumors

Recruiting
1/2
320
RoW
TST001, Oxaliplatin, Capecitabine, Paclitaxel, Gemcitabine, Cisplatin, Nivolumab
Suzhou Transcenta Therapeutics Co., Ltd., Bristol-Myers Squibb
Advanced Cancer
02/25
05/25
NCT05775900: Efficacy and Safety of Triweekly Cetuximab in Combination With Capecitabine as First-line Maintenance Treatment for KRAS/BRAF Wild-type Metastatic Colorectal Cancer

Recruiting
1/2
24
RoW
Cetuximab, Erbitux, Capecitabine, Capecitabine Tablets
Sun Yat-sen University
Metastatic Colorectal Cancer
12/24
12/24
CSPC-DEY-CRC-K06, NCT06434090: Liposomal Irinotecan Plus Bevacizumab in Irinotecan-refractory Metastatic Colorectal Cancer

Not yet recruiting
1/2
74
RoW
Liposomal irinotecan, Bevacizumab, avastin
Sun Yat-sen University
Colorectal Cancer
06/25
07/26
NCT06500676: A Study of GFH375 in Patients with Advanced Solid Tumors with KRAS G12D Mutations

Recruiting
1/2
290
RoW
GFH375
Genfleet Therapeutics (Shanghai) Inc.
KRAS G12D Mutations, Advanced Solid Tumors
07/28
12/28
NCT05176665: EMB-01 in Patients With Advanced/Metastatic Gastrointestinal Cancers

Recruiting
1/2
152
US, RoW
EMB-01, FIT-013a
Shanghai EpimAb Biotherapeutics Co., Ltd., Labcorp Corporation of America Holdings, Inc
Neoplasms, Neoplasm Metastasis, Metastatic Gastrointestinal Carcinoid Tumor
12/25
12/25
CSWOG-C03, NCT05426005: Cadonilimab for PD-1/PD-L1 Blockade-refractory, MSI-H/dMMR, Advanced Colorectal Cancer

Recruiting
1/2
28
RoW
Cadonilimab
Sun Yat-sen University
Colorectal Cancer Stage IV, Mismatch Repair-deficient (dMMR), Microsatellite Instability-high (MSI-H)
07/25
07/27
NCT04689100: Efficacy and Safety of JMT101 in Patients With Advanced Solid Tumor

Recruiting
1
259
RoW
JMT101, FOLFIRI(Irinotecan, Leucovorin Calcium, and Fluorouracil); mFOLFOX6((Oxaliplatin, Leucovorin Calcium, and Fluorouracil);, FOLFIRI; mFOLFOX6; Irinotecan;
Shanghai JMT-Bio Inc., CSPC ZhongQi Pharmaceutical Technology Co., Ltd.
Advanced Solid Tumor
12/21
06/22
NCT04930354: ECP-1014 Treatment for Patients With Solid Tumor Cancers

Recruiting
1
29
RoW
ECP-1014, GIBH-1014
Euclises Pharmaceuticals, Inc.
Solid Tumor
09/23
12/23
CSG-1906-101, NCT05857332: SG1906 for CLDN18.2-Positive Solid Tumors

Recruiting
1
60
RoW
SG1906
Hangzhou Sumgen Biotech Co., Ltd.
Locally Advanced Unresectable or Metastatic Solid Tumors
02/25
08/25
NCT06036862: Utilization of Transanal Endoscopy in the Treatment of Anastomotic Stenosis

Recruiting
N/A
50
RoW
Transanal and transabdominal combined endoscopic resection of rectal stenosis and anal reconstruction
Sun Yat-sen University
Anastomotic Stenosis
12/26
12/26
NCT06043999: Salvage Chemotherapy Versus Total Mesorectal Resection for Local Resection Rectal Cancer Patients

Recruiting
N/A
392
RoW
Radical total mesorectal excision, Salavge Adjuvant Chemoradiotherapy
Sun Yat-sen University
Chemotherapy Effect, Rectal Cancer
12/28
12/28
Peng, Junsheng
NCT06451393: Predicting Gastric Cancer Response to Chemo With Multimodal AI Model

Recruiting
N/A
500
RoW
Neoadjuvant chemotherapy with radical tumor resection surgery
Sixth Affiliated Hospital, Sun Yat-sen University
Gastric Cancer, Chemotherapy Effect
09/22
12/26
Li, Fei
HFN, NCT06238349: Hyperbilirubinemia in Full-term Neonates

Recruiting
4
200
RoW
Oral bifidobacterium triple live powder, Conventional treatment, Sunbathing, Sunbathing and the Oral bifidobacterium triple live powder
Zhuhai Center for Maternal and Child Health Care, Children's Hospital of Chongqing Medical University
Hyperbilirubinemia, Neonatal
06/24
06/24
RESCUE-GC, NCT02867839: Adjuvant Chemotherapy With S-1 Plus Oxaliplatin Versus S-1 Alone in Locally Advanced Gastric Cancer

Terminated
3
29
RoW
Oxaliplatin plus S-1, SOX, S-1 only, S-1
Peking University Cancer Hospital & Institute
Gastric Cancer
09/21
09/21
BRUIN CLL-321, NCT04666038: Study of LOXO-305 Versus Investigator's Choice (IdelaR or BR) in Patients With Previously Treated Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)

Active, not recruiting
3
250
Europe, Canada, Japan, US, RoW
LOXO-305, Pirtobrutinib, Idelalisib, Zydelig, Bendamustine, Treanda, Treakisym, Ribomustin, Levact, Rituximab, Rituxan, MabThera, Truxima
Loxo Oncology, Inc., Eli Lilly and Company
Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
08/23
05/27
FUMANBA-03, NCT06464991: A Phase III Study of Eque-cel in Subjects With Len-refractory RRMM

Recruiting
3
240
RoW
Equecabtagene Autoleucel Injection, FUCASO, Daratumumab, Pomalidomide, Bortezomib, Dexamethasone
Nanjing IASO Biotechnology Co., Ltd.
Multiple Myeloma
08/27
12/30
NCT06521255: Evaluate the Safety and Efficacy of Tafasitamab and Lenalidomide in Combination With Gemcitabine and Oxaliplatin Versus Rituximab in Combination With Gemcitabine and Oxaliplatin in Patients With Relapsed/Refractory Diffuse Large B-Cell Lymphoma

Recruiting
3
244
RoW
Tafasitamab, Lenalidomide, Gemcitabine, Oxaliplatin, Rituximab
Beijing InnoCare Pharma Tech Co., Ltd.
DLBCL
09/28
12/29
NCT06363994: A Global Phase 3 Study of Orelabrutinib+BR Vs.BR in Pts with TN MCL

Recruiting
3
476
RoW
Orelabrutinib, Bendamustine Injection, Rituximab, Orelabrutinib Placebo
InnoCare Pharma Inc.
Mantle Cell Lymphoma
06/31
06/32
BENCH, NCT04939142: A Study of Evaluating the Safety and Efficacy of ATG-010, Bortezomib, and Dexamethasone (SVd) Versus Bortezomib and Dexamethasone (Vd) in Patients with Relapsed or Refractory Multiple Myeloma (RRMM)

Active, not recruiting
3
150
RoW
SVd (Selinexor+Bortezomib+dexamethasone), Vd (Bortezomib+dexamethasone)
Antengene Corporation
Relapsed or Refractory Multiple Myeloma
12/25
12/25
BELIEVE-01, NCT05234684: A Study of Orelabrutinib Plus R-CHOP in Treatment-naïve Patients With MCD Subtype Diffuse Large B-cell Lymphoma

Recruiting
3
150
RoW
Orelabrutinib + R-CHOP, ICP-022+ R-CHOP, Placebo + R-CHOP
Beijing InnoCare Pharma Tech Co., Ltd.
Diffuse Large B Cell Lymphoma (DLBCL)
07/24
12/25
OASIS, NCT05101187: Olorofim Aspergillus Infection Study

Recruiting
3
225
Europe, Canada, Japan, US, RoW
Olorofim, Olorofim (F901318), AmBisome®, AmBisome® (liposomal amphotericin B)
F2G Biotech GmbH, Iqvia Pty Ltd, Shionogi
Invasive Aspergillosis
09/25
11/26
DREAMM8, NCT04484623 / 2018-004354-21: Belantamab Mafodotin Plus Pomalidomide and Dexamethasone (Pd) Versus Bortezomib Plus Pd in Relapsed/Refractory Multiple Myeloma

Hourglass Jul 2024 - Dec 2024 : Acceptance of regulatory submission in Japan for 2L+ multiple myeloma (based on DREAMM-8 trial)
Jan 2024 - Dec 2024: Regulatory approval in EU for 2L+ multiple myeloma (based on DREAMM-7 trial)
Jan 2024 - Dec 2024: Market entry for 2L multiple myeloma (based on DREAMM-7 trial)
Hourglass Oct 2024 - Dec 2024 : Acceptance of regulatory submission in US for 2L+ multiple myeloma
Hourglass Jul 2024 - Dec 2024 : Acceptance of regulatory submission in EU for 2L+ multiple myeloma (based on DREAMM-8 trial)
More
Recruiting
3
357
Europe, Japan, US, RoW
Belantamab mafodotin, Pomalidomide, Dexamethasone, Bortezomib
GlaxoSmithKline
Multiple Myeloma
01/24
05/29
CMML1-2, NCT06647862: IMM01+Azacitidine VS Placebo +Azacitidine in Patients With Newly Diagnosed Chronic Myelomonocytic Leukemia

Recruiting
3
170
RoW
IMM01, Timdarpacept, Azacitidine, Placebo
ImmuneOnco Biopharmaceuticals (Shanghai) Inc.
Chronic Myelomonocytic Leukemia
10/26
10/29
BRUIN CLL-313, NCT05023980: A Study of Pirtobrutinib (LOXO-305) Versus Bendamustine Plus Rituximab (BR) in Untreated Patients With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)

Active, not recruiting
3
250
Europe, Japan, US, RoW
Pirtobrutinib, LOXO-305, LY3527727, Bendamustine, Treanda, Treakisym, Ribomustin, Levact, Rituximab, Rituxan, MabThera, Truxima, Riabni, Ruxience
Loxo Oncology, Inc., Eli Lilly and Company
Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
04/25
08/26
TQ05105-III-01, NCT06682169: Evaluation of Rovadicitinib Compared to the Protocol Selected by Researchers in Third Line and Subsequent Studies of Moderate to Severe Chronic Graft-versus-host Disease

Recruiting
3
182
RoW
Rovadicitinib, Imatinib, Methotrexate, Mycophenolate mofetil, Rituximab
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Graft-versus-host Disease
10/29
12/30
NCT04578613: ICP-022 Versus Chlorambucil Combined With Rituximab in the Treatment of Untreated CLL/SLL

Recruiting
3
218
RoW
ICP-022, Chlorambucil, Rituximab
Beijing InnoCare Pharma Tech Co., Ltd.
Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
12/24
06/25
NCT05051891: A Randomized, Open-label, Multi-center, Phase III Study of Orelabrutinib in Combination With Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) vs. R-CHOP Alone in Patients With Treatment-naїve Mantle Cell Lymphoma

Recruiting
3
356
RoW
Orelabrutinib and R-CHOP, R-CHOP
Beijing InnoCare Pharma Tech Co., Ltd.
Treatment-naїve Mantle Cell Lymphoma
12/24
12/27
BRUIN-MCL-321, NCT04662255 / 2020-004553-72: Study of BTK Inhibitor LOXO-305 Versus Approved BTK Inhibitor Drugs in Patients With Mantle Cell Lymphoma (MCL)

Active, not recruiting
3
500
Europe, Canada, Japan, US, RoW
Pirtobrutinib, LOXO-305, LY3527727, Ibrutinib, Imbruvica, Acalabrutinib, Calquence, Zanubrutinib, Brukinsa
Loxo Oncology, Inc., Eli Lilly and Company
Lymphoma, Mantle-Cell
12/25
07/26
LOTIS 5, NCT04384484 / 2020-000241-14: Study to Evaluate Loncastuximab Tesirine With Rituximab Versus Immunochemotherapy in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma

Checkmark Safety run-in data from LOTIS-5 trial in combination with rituximab in r/r DLBCL at SOHO 2022
Sep 2022 - Sep 2022: Safety run-in data from LOTIS-5 trial in combination with rituximab in r/r DLBCL at SOHO 2022
Hourglass Sep 2021 - Dec 2021 : Submission for r/r DLBCL
Hourglass Nov 2021 - Dec 2021 : From LOTIS 5 trial in combination with rituximab for DLBCL
Active, not recruiting
3
440
Europe, Canada, Japan, US, RoW
Loncastuximab Tesirine, Zynlonta, ADCT-402, Rituximab, Gemcitabine, Oxaliplatin
ADC Therapeutics S.A., ADC Therapeutics SA
Relapsed Diffuse Large B-Cell Lymphoma, Refractory Diffuse Large B-Cell Lymphoma
06/25
06/28
DESTINY, NCT05334368: Depemokimab in Participants With Hypereosinophilic Syndrome, Efficacy, and Safety Trial

Recruiting
3
120
Europe, Canada, Japan, US, RoW
Depemokimab, Placebo
GlaxoSmithKline
Hypereosinophilic Syndrome
02/26
03/26
NCT05709093: A Phase 3 Clinical Study to Evaluate Lemzoparlimab for Injection in Combination With Azacitidine (AZA) Versus AZA Monotherapy in Treatment-naïve Patients With Higher-risk Myelodysplastic Syndrome (MDS)

Recruiting
3
552
RoW
Lemzoparlimab+Azacitidine (AZA), Azacitidine (AZA)
TJ Biopharma Co., Ltd.
Myelodysplastic Syndromes(MDS)
03/27
03/27
NCT06082102: Efficacy and Safety of Orelabrutinib Plus Lenalidomide and Rituximab (R2) Compared to Placebo Plus R2 in r/r Marginal Zone Lymphoma

Recruiting
3
324
RoW
Orelabrutinib, Lenalidomide, Rituximab, Orelabrutinib Placebo
Beijing InnoCare Pharma Tech Co., Ltd.
Relapsed/Refractory Marginal Zone Lymphoma
08/27
02/30
BRUIN-CLL-314, NCT05254743 / 2021-003206-41: A Study of Pirtobrutinib (LOXO-305) Versus Ibrutinib in Participants With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)

Active, not recruiting
3
650
Europe, Canada, Japan, US, RoW
Pirtobrutinib, LOXO-305, LY3527727, Ibrutinib
Loxo Oncology, Inc., Eli Lilly and Company
Chronic Lymphocytic Leukemia, Leukemia, Lymphocytic, Leukemia, B-cell, Small Lymphocytic Lymphoma
06/25
01/28
NCT04453345: TPM Regimen (Thalidomide, Prednisone and Methotrexate) in LGLL

Recruiting
2/3
42
RoW
thalidomide + prednisone + methotrexate, TPM regimen
Institute of Hematology & Blood Diseases Hospital, The First Affiliated Hospital of Nanchang University, First Affiliated Hospital of Guangxi Medical University, Henan Cancer Hospital, First Hospital of Jilin University, Central South University, Tianjin First Central Hospital
T-LGL Leukemia, Clpd-Nk
05/23
05/25
Haplo-HSCT, NCT06202625: Efficacy and Safety of Avatrombopag in the Treatment of Thrombocytopenia After

Recruiting
2/3
142
RoW
avatrombopag, Doptelet, Placebo
Peking University People's Hospital, Xiangya Hospital of Central South University, Sichuan Provincial People's Hospital, First Affiliated Hospital of Harbin Medical University, The First Affiliated Hospital of Zhengzhou University, First Affiliated Hospital of Xinjiang Medical University, Shanxi Bethune Hospital, 920th Hospital of Joint Logistics Support Force of People's Liberation Army of China, Tang-Du Hospital, The First Affiliated Hospital of Nanchang University
Thrombocytopenia, Stem Cell Transplant Complications
10/24
10/25
ICP-CL-01203, NCT06378138: ICP-248 in Combination With Orelabrutinib in Treatment-naïve Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Recruiting
2/3
226
RoW
ICP-248, Orelabrutinib
Beijing InnoCare Pharma Tech Co., Ltd.
Hematologic Malignancies
11/30
07/31
NCT05927792: Efficacy and Mechanism of Repetitive Transcranial Magnetic Stimulation in Children With Autism Spectrum Disorders

Recruiting
2/3
200
RoW
repeated transcranial magnetic stimulation (continuous theta-burst stimulation), sham repeated transcranial magnetic stimulation
Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Mental Health Center, Zhengzhou Children's Hospital, China, Qilu Hospital of Shandong University
Autism Spectrum Disorder
09/25
12/25
wAIHA, NCT05535933: HMPL-523 (Sovleplenib) in the Treatment of Warm Antibody Autoimmune Hemolytic Anemia

Recruiting
2/3
110
RoW
HMPL-523(300mg PO QD), Sovleplenib, Placebo
Hutchison Medipharma Limited
Warm Antibody Autoimmune Hemolytic Anemia
09/26
11/26
NCT06511895: AZD4205 in Relapsed or Refractory Peripheral T Cell Lymphoma (JACKPOT27)

Recruiting
2
150
RoW
AZD4205
Dizal Pharmaceuticals
Peripheral T Cell Lymphoma
05/25
12/26
NCT03837873: DLCL002 Protocol for Patients With High Risk Aggressive B-cell Lymphoma

Recruiting
2
118
RoW
Rituximab, Etoposide, Vincristine, Doxorubicin, Dexamethasone, Cyclophosphamide, Lenalidomide, Cisplatin, Cytarabine
Institute of Hematology & Blood Diseases Hospital
Diffuse Large B Cell Lymphoma, High-grade B-cell Lymphoma, Transformed Lymphoma
09/23
09/24
NCT05147467: Study of APG-2575 in Patients With Relapsed/Refractory CLL/SLL

Recruiting
2
75
RoW
APG2575
Ascentage Pharma Group Inc.
Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
09/24
12/24
NCT05320081: Camrelizumab Combined With CD30 CAR-T in the Treatment of Relapsed/Refractory CD30+ Lymphoma

Recruiting
2
30
RoW
CD30 CAR-T, Camrelizumab
Huazhong University of Science and Technology, The First Affiliated Hospital of Nanchang University
Lymphoma, Relapse/Recurrence
12/23
06/24
NCT05334823: A Study of pCAR-19B in the Treatment of CD19-positive Relapsed/Refractory B-ALL in Children and Adolescents

Recruiting
2
100
RoW
pCAR-19B cells
Chongqing Precision Biotech Co., Ltd
Acute Lymphoblastic Leukemia, Relapsed Pediatric ALL, Refractory Acute Lymphoblastic Leukemia
12/24
07/25
NCT05716087: A Study of Rocbrutinib in Participants with Relapse or Refractory Mantle Cell Lymphoma

Active, not recruiting
2
62
RoW
Rocbrutinib, NWP-775, LP-168
Guangzhou Lupeng Pharmaceutical Company LTD.
Mantle Cell Lymphoma (MCL)
12/24
12/25
NCT04849351: Clinical Study of HMPL-689 for Relapsed/Refractory Marginal Zone Lymphoma and Follicular Lymphoma

Recruiting
2
185
RoW
HMPL-689, Phosphatidylinositol 3-kinase-δ inhibitor
Hutchison Medipharma Limited
Marginal Zone Lymphoma, Follicular Lymphoma
04/24
12/24
BDHRT001, NCT04992377: R-EPOCH in Combination With Ibrutinib for Patients With Classical RT of CLL

Not yet recruiting
2
30
RoW
R-EPOCH in Combination With Ibrutinib
Institute of Hematology & Blood Diseases Hospital, Xian-Janssen Pharmaceutical Ltd.
Richter Transformation
08/24
08/25
NCT06601504: Study of HMPL-760 Plus R-GemOx Versus Placebo Plus R-GemOx in Relapsed/Refractory DLBCL

Recruiting
2
60
RoW
HMPL-760 planned dose 1, R-GemOx, Rituximab Injection, Gemcitabine Hydrochloride for Injection, Gemcitabine Hydrochloride for Injection, HMPL-760 placebo planned dose 1, HMPL-760 planned dose 2, HMPL-760 placebo planned dose 2
Hutchmed
Relapsed/Refractory Diffuse Large B-Cell Lymphoma
05/26
11/26
TQB3702-II-02, NCT06566586: A Clinical Study to Evaluate the Efficacy and Safety of TQB3702 Tablets Combined With Immunochemotherapy for the Treatment of B-cell Lymphoma

Recruiting
2
80
RoW
TQB3702 tablets+Chemotherapy regimen
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
B-cell Lymphoma
03/26
12/27
 

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