University Health Network Toronto General Hospital
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 12 Trials 
22 Trials

   

 
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Bril, Vera
NCT06587867: Seronegative Myasthenia Gravis - Efgartigimod IV

Recruiting
3
30
Canada
efgartigimod
University Health Network, Toronto
Efgartigimod, Generalized Myasthenia Gravis
05/25
05/25
NIMBLE, NCT05070858 / 2020-003272-41: A Study to Test How Safe Pozelimab and Cemdisiran Combination Therapy and Cemdisiran Alone Are and How Well They Work in Adult Patients With Generalized Myasthenia Gravis

Recruiting
3
235
Europe, Canada, Japan, US, RoW
Pozelimab + Cemdisiran, Cemdisiran, ALN-CC5, Placebo, Pozelimab, REGN3918
Regeneron Pharmaceuticals
Generalized Myasthenia Gravis
05/25
03/28
NEPTUNE-17, NCT05838755: A Study to Evaluate Efficacy and Safety of GSK3858279 in Diabetic Peripheral Neuropathic Pain

Active, not recruiting
2
145
Europe, Canada, Japan, US, RoW
GSK3858279, Placebo
GlaxoSmithKline
Pain
10/24
01/25
Feld, Jordan
NCT04017338: Transplantation Using Hepatitis C Positive Donors, A Safety Trial

Recruiting
3
40
Canada
Glecaprevir 300 MG / Pibrentasvir 120 MG Oral Tablet, Maviret, Ezetimibe 10Mg Oral Tablet, Ex Vivo Lung Perfusion, Normothermic EVLP
Jordan Feld, University Health Network, Toronto
Lung Transplant Infection, Heart Transplant Infection, Kidney Transplant Infection, Kidney Pancreas Infection, Hepatitis C
12/20
12/24
NCT04967430: TOGETHER - Toronto: Trial to Evaluate the Effect of Peginterferon Lambda for the Treatment of COVID-19

Active, not recruiting
3
763
Canada
Peginterferon Lambda-1A, Placebo
University Health Network, Toronto
Sars-CoV2, Covid19
03/22
06/22
D-LIVR, NCT03719313 / 2018-003167-54: Study of the Efficacy and Safety of Lonafarnib / Ritonavir With and Without Pegylated Interferon -Alfa-2a

Completed
3
407
Europe, Canada, US, RoW
Lonafarnib, EBP994, Sarasar, LNF, Ritonavir, Norvir, RTV, PEG IFN-alfa-2a, Pegasys, pegylated interferon-alfa, Placebo Lonafarnib, Placebo Ritonavir
Eiger BioPharmaceuticals
Hepatitis Delta Virus
10/22
03/23
ILIAD, NCT04354259: Interferon Lambda for Immediate Antiviral Therapy at Diagnosis in COVID-19

Completed
2
157
Canada, RoW
Peginterferon Lambda-1A, placebo
University Health Network, Toronto, Michael Garron Hospital
Sars-CoV2, Covid-19
08/22
12/22
B-Fine, NCT04544956: A Mechanistic Study of GSK3228836 With Fine Needle Aspiration (FNA) in Participants With Chronic Hepatitis B

Completed
2
12
Europe, Canada, US
GSK3228836, Nucleos(t)ide therapy
GlaxoSmithKline
Hepatitis B
11/23
11/23
NCT06216470: Vaccinal Effect of HBsAg Monoclonal Ab VIR-3434 in Chronic Hepatitis B Infection [VISION]

Recruiting
2
15
Canada
VIR-3434
University Health Network, Toronto
Hepatitis B, Chronic
12/29
12/29
B-Sure, NCT04954859 / 2021-000554-26: Long-term Follow-up Study to Evaluate Durability of Treatment Response in Previous Bepirovirsen Study Participants

Recruiting
2
450
Europe, Canada, Japan, US, RoW
Bepirovirsen, Placebo
GlaxoSmithKline, GlaxoSmithKline Research & Development Limited
Hepatitis B
02/29
02/29
RAPID-HCV, NCT04677153: Rapid HCV Treatment Access for Persons Who Use Drugs

Completed
N/A
124
Canada, US
Test and treat plus peer mentors, On-site treatment with peer support HCV treatment implementation strategy, Usual care, Standard of care referral HCV treatment implementation strategy
Johns Hopkins University, AbbVie
Hepatitis C Virus Infection, Response to Therapy of
02/24
09/24
Cypel, Marcelo
NCI-2018-01456, NCT03599752: Chemotherapy and/or Metastasectomy in Treating Patients With Metastatic Colorectal Adenocarcinoma With Lung Metastases

Active, not recruiting
2
40
Canada, US
Chemotherapy, Chemo, Chemotherapy (NOS), Chemotherapy, Cancer, General, Metastasectomy
M.D. Anderson Cancer Center, National Cancer Institute (NCI)
Colorectal Adenocarcinoma, Colorectal Carcinoma Metastatic in the Lung, Stage IV Colorectal Cancer AJCC v8, Stage IVA Colorectal Cancer AJCC v8, Stage IVB Colorectal Cancer AJCC v8, Stage IVC Colorectal Cancer AJCC v8
01/30
01/30
NCT03112044: Lung Transplant HCV, Pilot Study

Active, not recruiting
1
26
Canada
Sofosbuvir-velpatasvir (400 mg/100 mg), Epclusa, Ex Vivo Lung Perfusion (EVLP), Normothermic EVLP
University Health Network, Toronto, Gilead Sciences
Lung Transplant Infection, Hepatitis C
01/20
12/24
NCT02811523: In Vivo Lung Perfusion for Pulmonary Metastases of Sarcoma

Recruiting
1
17
Canada
Doxorubicin
University Health Network, Toronto
Bone Sarcoma, Soft Tissue Sarcoma, Pulmonary Metastases
02/25
02/25
NCT05611034: In Vivo Lung Perfusion (IVLP) for Colorectal Cancer Metastatic to Lung

Recruiting
1
10
Canada
Oxaliplatin
University Health Network, Toronto
Lung Metastases, Colorectal Cancer Metastatic, Colorectal Cancer
01/27
01/32
NCT04616365: Planned Semi-Elective Lung Tx Study

Completed
N/A
70
Europe, Canada
Semi-Elective Lung Transplantation
University Health Network, Toronto
Lung Transplantation
04/22
04/23
ULTIMATE, NCT04832789: Ultra-Low Tidal Volume Mechanical Ventilation in ARDS Through ECMO

Not yet recruiting
N/A
72
Canada, US
Venovenous ECMO
University of Toronto, University Health Network, Toronto
ARDS
06/23
12/23
REVOLUTION, NCT06615492: Routine vs On-demand ECMO for Lung Transplantation

Not yet recruiting
N/A
218
Canada
Routine ECMO, On-demand ECMO
Centre hospitalier de l'Université de Montréal (CHUM)
Respiratory Failure, Interstitial Lung Disease (ILD), Pulmonary Fibrosis, COPD (Chronic Obstructive Pulmonary Disease)
10/28
12/28
NCT05898776: 10°C Vs 4°C Lung Preservation RCT

Recruiting
N/A
300
Europe, Canada, US, RoW
Lung transplantation after 10°C donor lung preservation, Lung transplantation after standard ice cooler donor lung preservation
University Health Network, Toronto, Medical University of Vienna, Vanderbilt University, Puerta de Hierro University Hospital, University of California, San Francisco, Centre Hospitalier Universitaire Vaudois, Mayo Clinic, St Vincent's Hospital, Sydney
Lung Transplant, Organ Preservation
07/25
07/26
Ng, Eduardo
NCT06587867: Seronegative Myasthenia Gravis - Efgartigimod IV

Recruiting
3
30
Canada
efgartigimod
University Health Network, Toronto
Efgartigimod, Generalized Myasthenia Gravis
05/25
05/25
MG_SCIG, NCT04728425: Subcutaneous Immunoglobulin for Myasthenia Gravis

Recruiting
2
30
Canada
subcutaneous immunoglobulin (SCIG), Cuvitru, intravenous immunoglobulin + subcutaneous immunoglobulin (SCIG), Gammanorm + Cuvitru
University Health Network, Toronto
Myasthenia Gravis
06/23
12/23
Aguilera, Carlota
HIBISCUS, NCT04624659 / 2020-003884-25: A Study of Etavopivat in Adults and Adolescents With Sickle Cell Disease

Recruiting
2/3
344
Europe, Canada, US, RoW
Etavopivat Tablets Low dose, FT-4202, Etavopivat Tablets High dose, Placebo Tablets, placebo, Etavopivat Tablets
Forma Therapeutics, Inc., Novo Nordisk A/S
Sickle Cell Disease
03/26
04/27

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