| Shelton, Richard C |
| Not yet recruiting | 4 | 2726 | Canada, US | Cariprazine, Vraylar, Aripiprazole/Escitalopram combination, Abilify/ Lexapro, Quetiapine, Seroquel, Lurasidone, Latuda | Massachusetts General Hospital, Patient-Centered Outcomes Research Institute | Bipolar I Disorder, Depression | 02/30 | 02/30 | | |
NCT05169710 / 2021-002126-24: A Clinical Study of an Investigational Drug for the Treatment of Major Depressive Episode Associated With Bipolar I Disorder. |
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| Terminated | 3 | 83 | Europe, Canada, Japan, US | SEP-4199 CR 200 mg, SEP-4199 CR 400 mg, Placebo | Sumitomo Pharma America, Inc., Sunovion Pharmaceuticals Inc. | Depressive Episodes, Bipolar I Depression | 10/23 | 10/23 | | |
NCT05729373: A Clinical Study That Will Measure How Well SEP-363856 Works and How Safe it is in Adults With Generalized Anxiety Disorder |
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| Recruiting | 2/3 | 434 | Europe, Japan, US | SEP-363856, Placebo | Otsuka Pharmaceutical Development & Commercialization, Inc. | Generalized Anxiety Disorder | 02/26 | 02/26 | | |
ENLIGHTEN, NCT05113771: A Biomarker-Guided, Randomized, Double-Blind, Placebo-Controlled Efficacy and Safety Study of Liafensine in Patients With Treatment-Resistant Depression |
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| Completed | 2 | 197 | Canada, US | Liafensine, Placebo | Denovo Biopharma LLC | Treatment Resistant Depression | 02/24 | 03/24 | | |
NCT04923685: MicroRNA Correlates of Childhood Maltreatment and Suicidality |
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| Recruiting | N/A | 450 | US | Trier Social Stress Test, TSST | University of Alabama at Birmingham, National Institute of Mental Health (NIMH) | Major Depressive Disorder, Suicidal Ideation | 09/25 | 09/25 | | |
NCT05437588: Neural-Derived Plasma Exosomal MicroRNAs As Promising Novel Biomarkers for Suicidality and Treatment Outcome in Adolescents |
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| Recruiting | N/A | 240 | US | Genetic testing | University of Alabama at Birmingham, National Institute of Mental Health (NIMH) | Major Depressive Disorder, Suicidal Ideas, Suicide, Attempted, MDD, Depression, Depression, Teen, Depression and Suicide, Depression in Adolescence, Suicide | 06/27 | 06/27 | | |
RECOVER, NCT03887715: A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression |
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| Recruiting | N/A | 6800 | US | Vagus Nerve Stimulation (VNS), VNS | LivaNova | Treatment Resistant Depression | 02/28 | 12/30 | | |
| Howell, Michael |
NCT06467461: Identification of Prodromal Neurodegeneration in Serotonergic-Induced REM Sleep Behavior Disorder |
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| Recruiting | N/A | 60 | US | Skin biopsy, Speech testing, Ultra high field 7T MRI | University of Minnesota | Dementia With Lewy Bodies, Parkinson Disease, REM Sleep Behavior Disorder | 09/28 | 12/28 | | |
| Recruiting | N/A | 500 | Canada, US | | Washington University School of Medicine, Mayo Clinic, University of Minnesota, University of California, Los Angeles, McGill University, Emory University, Massachusetts General Hospital, National Institute of Neurological Disorders and Stroke (NINDS), Stanford University, National Institutes of Health (NIH), Oregon Health and Science University, National Institute on Aging (NIA) | REM Sleep Behavior Disorder, Parkinson Disease, Lewy Body Dementia, Dementia With Lewy Bodies, Multiple System Atrophy, REM Sleep Parasomnias | 05/25 | 05/25 | | |
RECOVER, NCT03887715: A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression |
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| Recruiting | N/A | 6800 | US | Vagus Nerve Stimulation (VNS), VNS | LivaNova | Treatment Resistant Depression | 02/28 | 12/30 | | |
| Macaluso, Matthew |
| Not yet recruiting | 4 | 2726 | Canada, US | Cariprazine, Vraylar, Aripiprazole/Escitalopram combination, Abilify/ Lexapro, Quetiapine, Seroquel, Lurasidone, Latuda | Massachusetts General Hospital, Patient-Centered Outcomes Research Institute | Bipolar I Disorder, Depression | 02/30 | 02/30 | | |
NCT04990687: Vagal Nerve Stimulation for Treatment Resistant Major Depression |
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| Completed | N/A | 5 | US | gammaCore™ | University of Alabama at Birmingham | Major Depressive Disorder | 09/23 | 04/24 | | |
RECOVER, NCT03887715: A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression |
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| Recruiting | N/A | 6800 | US | Vagus Nerve Stimulation (VNS), VNS | LivaNova | Treatment Resistant Depression | 02/28 | 12/30 | | |
