| Middleton, Gary W |
| Active, not recruiting | 3 | 600 | Europe, Canada, US, RoW | Gotistobart, A humanized anti-CTLA4 IgG1 monoclonal antibody, ONC-392, BNT316, Docetaxel, Docefrez, Taxotere | OncoC4, Inc., BioNTech SE | Non Small Cell Lung Cancer | 06/26 | 06/27 | | |
DETERMINE, NCT05768178: Trial Treatment Arm 05: Vemurafenib in Combination With Cobimetinib in Adult Patients With BRAF Positive Cancers. |
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| Recruiting | 2/3 | 30 | Europe | Vemurafenib, Zelboraf, Cobimetinib, Cotellic | Cancer Research UK, University of Manchester, University of Birmingham, Royal Marsden NHS Foundation Trust, Hoffmann-La Roche | Solid Tumor, Haematological Malignancy, Melanoma, Thyroid Cancer, Papillary, Ovarian Neoplasms, Colorectal Neoplasms, Laryngeal Neoplasms, Carcinoma, Non-Small-Cell Lung, Glioma, Multiple Myeloma, Erdheim-Chester Disease, Thyroid Carcinoma, Anaplastic | 10/29 | 10/29 | | |
CRUKD/21/004, NCT05722886: DETERMINE (Determining Extended Therapeutic Indications for Existing Drugs in Rare Molecularly Defined Indications Using a National Evaluation Platform Trial) - Master Screening Protocol |
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| Recruiting | 2/3 | 825 | Europe | Alectinib, Alecensa, Atezolizumab, Tecentriq, Entrectinib, Rozlytrek, Trastuzumab in combination with pertuzumab, Herceptin in combination with Perjeta, Vemurafenib in combination with cobimetinib, Zelboraf in combination with Cotellic | Cancer Research UK, University of Manchester, University of Birmingham, Royal Marsden NHS Foundation Trust, Hoffmann-La Roche | Solid Tumor, Haematological Malignancy | 10/29 | 10/29 | | |
DETERMINE, NCT05786716: Trial Treatment Arm 04: Trastuzumab in Combination With Pertuzumab in Adult, Teenage/Young Adult and Paediatric Patients With Cancers With HER2 Amplification or Activating Mutations |
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| Recruiting | 2/3 | 30 | Europe | Trastuzumab, Herceptin, Pertuzumab, Perjeta | Cancer Research UK, University of Manchester, University of Birmingham, Royal Marsden NHS Foundation Trust, Hoffmann-La Roche | Solid Tumor, Haematological Malignancy, Colorectal Neoplasms, Urinary Bladder Neoplasm, Gallbladder Neoplasms, Salivary Gland Neoplasm, Lung Neoplasm, Pancreatic Neoplasm, Ovarian Neoplasms, Prostatic Neoplasm, Skin Neoplasm | 10/29 | 10/29 | | |
DETERMINE, NCT05770102: Trial Treatment Arm 02: Atezolizumab in Adult, Teenage/Young Adults and Paediatric Patients With Cancers With High Tumour Mutational Burden (TMB) or Microsatellite Instability-high (MSI-high) or Proven Constitutional Mismatch Repair Deficiency (CMMRD) Disposition |
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| Recruiting | 2/3 | 30 | Europe | Atezolizumab, Tecentriq | Cancer Research UK, University of Manchester, University of Birmingham, Royal Marsden NHS Foundation Trust, Hoffmann-La Roche | Malignancy, Malignant Neoplasm, Lymphoproliferative Disorders, Neoplasms by Histologic Type, Neoplasms by Site, Cancer, Colorectal Neoplasms, Endometrial Neoplasms, Melanoma | 10/29 | 10/29 | | |
DETERMINE, NCT05770037: Trial Treatment Arm 01: Alectinib in Adult, Teenage/Young Adults (TYA) and Paediatric Patients With ALK Positive Cancers |
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| Recruiting | 2/3 | 30 | Europe | Alectinib, Alecensa | Cancer Research UK, University of Manchester, University of Birmingham, Royal Marsden NHS Foundation Trust, Hoffmann-La Roche | Solid Tumor, Haematological Malignancy, Malignant Neoplasm, Lymphoproliferative Disorders, Neoplasms by Histologic Type, Neoplasms by Site, Cancer, Anaplastic Large Cell Lymphoma, Lymphoma, Renal Cell Carcinoma, Neuroblastoma | 10/29 | 10/29 | | |
DETERMINE, NCT05770544: Trial Treatment Arm 03: Entrectinib in Adult, Teenage/Young Adults and Paediatric Patients With ROS1 Gene Fusion-positive Cancers. |
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| Recruiting | 2/3 | 30 | Europe | Entrectinib, Rozlytrek | Cancer Research UK, University of Manchester, University of Birmingham, Royal Marsden NHS Foundation Trust, Hoffmann-La Roche | Solid Tumor, Haematological Malignancy, Malignancy, Malignant Neoplasm, Lymphoproliferative Disorders, Neoplasms by Histologic Type, Neoplasms by Site, Cancer, Brain Neoplasms, Melanoma, Glioma | 10/29 | 10/29 | | |
| Active, not recruiting | 2 | 62 | Europe | pembrolizumab, MK-3475 | University of Birmingham, Merck Sharp & Dohme LLC | Carcinoma, Non-Small-Cell Lung | 02/23 | 02/24 | | |
| Active, not recruiting | 2 | 35 | Europe | Nivolumab, Opdivo | University of Birmingham, Bristol-Myers Squibb | Colorectal Cancer | 10/24 | 10/24 | | |
| Active, not recruiting | 2 | 423 | Europe | AZD4547, Vistusertib, AZD2014, Palbociclib, Crizotinib, Selumetinib, AZD6244, Docetaxel, AZD5363, Osimertinib, AZD9291, Durvalumab, MEDI4736, Sitravatinib, MGCD516, AZD6738 | University of Birmingham, Cancer Research UK, AstraZeneca, Pfizer, Experimental Cancer Medicine Centres, Mirati Therapeutics Inc. | Non-Small Cell Lung Cancer, Carcinoma, Squamous Cell, Adenocarcinoma | 09/24 | 09/24 | | |
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NCT04785365: Long-Term Follow-Up Study of Patients Receiving ATL001 |
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| Terminated | 2 | 1 | Europe | Biological: ATL001 | Achilles Therapeutics UK Limited | Melanoma, Advanced Non Small Cell Lung Cancer | 10/23 | 10/23 | | |
| Completed | 1/2 | 72 | Europe | BT1718 | Cancer Research UK, Bicycle Therapeutics | Advanced Solid Tumours, Non-Small Cell Lung Cancer, Non-Small Cell Lung Sarcoma, Oesophageal Cancer | 11/23 | 11/23 | | |
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| Suspended | 1/2 | 103 | Europe | ChAdOx1-MAGEA3-NYESO, MVA-MAGEA3, Standard of care treatment, MVA-NYESO | Cancer Research UK, Barinthus Biotherapeutics | Non-small Cell Lung Cancer (NSCLC), Esophageal Neoplasms | 12/27 | 12/27 | | |
| Completed | 1 | 9 | Europe | AST-VAC2 | Cancer Research UK | Advanced Non-small Cell Lung Cancer | 08/22 | 08/22 | | |
| Frenneaux, Michael |
| Not yet recruiting | 2 | 2000 | RoW | Transdermal estradiol gel, oestrogel, estrogel | Hamad Medical Corporation, Laboratoires Besins International | COVID-19 | 02/22 | 03/22 | | |
| Phan, Thanh T |
NCT04419961: Sexual Dysfunction and an Educational Program to Improve the Quality of Sexual Function in Vietnamese Pregnant Women in First Trimester |
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| Recruiting | N/A | 350 | RoW | Educational program | National Hospital of Obstetrics and Gynecology | Female Sexual Dysfunction | 10/21 | 12/21 | | |
MCR-HF, NCT06516562: Demographic, Clinical, Biological, Treatment Characteristics and Cardiovascular Events of Patients With Heart Failure in Vietnam: a Multicenter Prospective Observational Study |
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| Recruiting | N/A | 2500 | RoW | Optimal treatment | University Medical Center Ho Chi Minh City (UMC) | Heart Failure, Heart Failure With Reduced Ejection Fraction, Heart Failure With Mid Range Ejection Fraction | 08/27 | 06/28 | | |
| Dietrich, Thomas |
NCT05584566: Ridge Augmentation Treatment Using OSSIX® BREEZE vs Jason® |
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| Recruiting | N/A | 65 | Europe, RoW | OSSIX Breeze, Jason membrane | Datum Dental LTD | Ridge Augmentation | 06/26 | 07/26 | | |
NCT05355792: Multicenter Study to Evaluate the Clinical Outcome of the OmniTaper EV Implant in Single Tooth Restorations |
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| Active, not recruiting | N/A | 139 | Europe | OmniTaper EV implants, OmniTaper EV implants UDI 0739253224012WR | Dentsply Sirona Implants and Consumables | Jaw, Edentulous | 11/28 | 01/29 | | |
| Kirchhof, Paulus |
CABA-HFPEF, NCT05508256: CAtheter-Based Ablation of Atrial Fibrillation Compared to Conventional Treatment in Patients With Heart Failure With Preserved Ejection Fraction |
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| Recruiting | 4 | 1548 | Europe | CE-marked Catheter Ablation | Charite University, Berlin, Germany, Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK), Kompetenznetz Vorhofflimmern e.V. (AFNET), Boston Scientific Corporation | Atrial Fibrillation, Heart Failure With Preserved Ejection Fraction, Heart Failure With Mildly Reduced Ejection Fraction | 07/26 | 07/27 | | |
| Terminated | 3 | 2608 | Europe, RoW | Edoxaban, Lixiana, Savaysa, ASA, ASS | Atrial Fibrillation Network, Daiichi Sankyo Europe, GmbH, a Daiichi Sankyo Company, Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK) | Atrial High Rate Episodes | 12/22 | 12/22 | | |
NCT06324188: Early Atrial Fibrillation Ablation for Stroke Prevention in Patients with High Comorbidity Burden (EASThigh-AFNET 11) |
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| Recruiting | N/A | 2312 | Europe, Canada, RoW | Early atrial fibrillation ablation, Usual Care | Atrial Fibrillation Network | Atrial Fibrillation | 02/30 | 05/30 | | |
| Recruiting | N/A | 5000 | Europe | | Universitätsklinikum Hamburg-Eppendorf | Arrhythmias, Cardiac, Atrial Fibrillation, Atrial Flutter, Ventricular Tachycardia, Atrial Tachycardia, Arrhythmogenic Right Ventricular Dysplasia, Long QT Syndrome, Brugada Syndrome, Supraventricular Tachycardia, Catecholaminergic Polymorphic Ventricular Tachycardia, Torsades de Pointes, Atrial Cardiomyopathy | 09/26 | 12/31 | | |
| Sinclair, Alexandra |
| Active, not recruiting | N/A | 90 | Europe | Bariatric surgery, Dietetic intervention, Weight Watchers | University of Birmingham, National Institute for Health Research, United Kingdom | Idiopathic Intracranial Hypertension | 08/18 | 08/22 | | |
| Bhangu, Aneel |
| Not yet recruiting | 3 | 6400 | NA | RESP301 | University of Birmingham, Christian Medical College and Hospital, Ludhiana, India, Tamale Teaching Hospital, Ghana., University of Lagos, Nigeria, Kigali University Teaching Hospital, Hospital Español Veracruz, Université d'Abomey-Calavi, University of Witwatersrand, South Africa, University of Edinburgh, Istituto Clinico Humanitas, University of Cape Town | Pulmonary Complications in Surgical Patients, COVID, Severe Acute Respiratory Syndrome | 05/22 | 05/26 | | |
TIGER, NCT06165133: Task Sharing in InGuinal hErnia Repair Between Surgeons and Non-surgeon Physicians |
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| Not yet recruiting | N/A | 1782 | NA | Mesh inguinal hernia repair performed by Non-Surgeon Physicians (NSP), Mesh inguinal hernia repair performed by fully trained surgeons | University of Birmingham, Tamale Teaching Hospital, Ghana., University of Abomey Calavi, Benin | Inguinal Hernia | 05/26 | 06/26 | | |
| Not yet recruiting | N/A | 26800 | NA | Intervention: Reusable drapes and gowns, Comparator: Disposable (single-use) drapes and gowns | University of Birmingham, Christian Medical College, Vellore, India, Kigali University Teaching Hospital, Lagos State University, Hospital Español de Mexico, Christian Medical College and Hospital, Ludhiana, India, Centre National Hospitalier Universitaire Hubert Koutoukou MAGA, University for Development Studies, Tamale, Ghana, Chris Hani Baragwanath Academic Hospital | Surgical Site Infection | 06/26 | 07/26 | | |
| Not yet recruiting | N/A | 14000 | RoW | Appendicectomy | University of Birmingham, Christian Medical College and Hospital, Ludhiana, India, Tamale Teaching Hospital, Ghana., Lagos University Teaching Hospital (LUTH), Hospital Español Veracruz, WITS Health Consortium (South Africa), University of Abomey Calavi, Benin, Kigali University Teaching Hospital | Appendicitis, Appendectomy | 07/25 | 12/25 | | |
| Not yet recruiting | N/A | 2000 | Europe | Surgery (across all specialities) | University of Birmingham | SARS-CoV-2 Infection, Surgery | 02/22 | 03/22 | | |
| Thomas, Jason M |
NCT06366399: The Acute T-Rex (Timing of Resistance Exercise) Study |
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| Recruiting | N/A | 20 | US | Resistance Exercise Timing, Exercise, Strength-Training, Weightlifting | University of Utah | Diabetes Mellitus, Type 2, Insulin Resistance, Glucose Intolerance, Sleep Disturbance, Overweight or Obesity, Insulin Sensitivity | 12/24 | 12/24 | | |
| Scarisbrick, Julia |
REACH, NCT04218825: Study to Determine the Aetiology of Chlormethine Gel Induced-skin Drug Reaction in Early Stage Mycosis Fungoides Cutaneous T Cell Lymphoma (MF-CTCL) |
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| Terminated | 2 | 2 | Europe | chlormethine gel, Ledaga® | European Organisation for Research and Treatment of Cancer - EORTC | Early Stage Mycosis Fungoides Cutaneous T Cell Lymphoma (MF-CTCL) (Stage IA-IB) | 04/23 | 04/23 | | |
| Recruiting | N/A | 4975 | Europe, RoW | RP-1828 IMMUcan, RP-1759 AYA/TYA, RP-1843 Arcagen, RP-1920 BioRadon | European Organisation for Research and Treatment of Cancer - EORTC | All Tumor Types | 03/26 | 03/26 | | |
NCT02848274: ID Of Prognostic Factors In Mycosis Fungoides/Sezary Syndrome |
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| Recruiting | N/A | 2000 | Europe, Japan, US, RoW | | Stanford University | Mycosis Fungoides, Non-Hodgkin's Lymphoma | 03/27 | 03/27 | | |
| Serner, Andreas |
NCT05488639: Injury and Illness Surveillance at FIFA U-17 & U-20 Women's World Cups. |
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| Suspended | N/A | 672 | Europe | Registration of football exposure and occurrence of injuries and illnesses only | Federation Internationale de Football Association | Injuries, Illness | 10/22 | 12/24 | | |
| Enrolling by invitation | N/A | 100 | Europe | The Sport Concussion Assessment Tool 5th Edition (SCAT5), The Immediate Post-Concussion Assessment and Cognitive Testing tool version 4 (ImPACT) | Federation Internationale de Football Association, University of Birmingham | Cerebral Concussion, Brain Concussion, Post-Concussion Symptoms, TBI (Traumatic Brain Injury) | 08/24 | 08/25 | | |
| Martin, Una |
| Recruiting | 4 | 1320 | Europe | Amlodipine, Lisinopril, Amiloride, Chlortalidone | Cambridge University Hospitals NHS Foundation Trust, Medical Research Council | Hypertension | 01/22 | 12/22 | | |
| Sharif, Adnan |
| Not yet recruiting | N/A | 85410 | Europe | | University Hospital Birmingham NHS Foundation Trust | Malignancy | 02/23 | 02/23 | | |
| Recruiting | N/A | 150 | Europe, RoW | No Intervention | Takeda | Cytomegalovirus (CMV) | 04/25 | 04/25 | | |
| Morgan, Matthew |
| Active, not recruiting | N/A | 153 | US | Capillary Collection & Testing, Venous Draw & Testing | LumiraDx UK Limited | Covid19 | 12/20 | 09/23 | | |
| Active, not recruiting | N/A | 200 | US | Venepuncture, Fingerstick | LumiraDx UK Limited | Embolism and Thrombosis, Infection, Inflammation | 04/22 | 03/24 | | |
INSPIRE, NCT04288921: Evaluation of Performance of the LumiraDx Influenza A/B + RSV Test at POC Testing Sites |
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| Recruiting | N/A | 2000 | US | Swab | LumiraDx UK Limited | Influenza, Human, Respiratory Syncytial Virus Infections | 09/23 | 09/23 | | |
| Coordinator, Research |
| Recruiting | 4 | 292 | US | Amnion-Intermediate-Chorion, AIC, Amnion-Chorion-Amnion, ACA, Standard of Care, SOC | Cellution Biologics, SerenaGroup, Inc., LifeCell | Diabetic Foot Ulcer, Venous Leg Ulcer | 12/26 | 07/27 | | |
| Recruiting | 4 | 2650 | US | Zoledronic Acid 5Mg/Bag 100Ml Inj, Reclast, Placebo | California Pacific Medical Center Research Institute, National Institute on Aging (NIA), University of California, San Francisco, Duke University, University of Pittsburgh, Parkinson's Foundation | Parkinson Disease, Osteoporosis, Parkinsonism, Parkinson's Disease and Parkinsonism, Atypical Parkinsonism, Progressive Supranuclear Palsy, Multiple System Atrophy, Vascular Parkinsonism, Dementia With Lewy Bodies | 10/25 | 10/25 | | |
NCT05078827: Therapeutic Equivalence of Fluorouracil Cream, 5% Compared With Fluorouracil 5% Topical Cream of MylanPharmaceuticals Inc., U.S.A in the Treatment of Actinic Keratosis |
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| Completed | 3 | 458 | US | Test Product (A): Fluorouracil Cream, 5% topical cream, Experimental, Reference Product (B): Fluorouracil 5% Topical Cream of Mylan Pharmaceuticals Inc., Morgantown, WV 26505 U.S.A., Active Comparator, Placebo Product (C): Test vehicle cream for fluorouracil 5% of Encube Ethicals Pvt. Ltd., India, Placebo Comparator | Encube Ethicals Pvt. Ltd., CBCC Global Research | Actinic Keratoses | 11/22 | 12/22 | | |
| Completed | 3 | 558 | US | ReMMi-D Digital Therapeutic | Click Therapeutics, Inc. | Migraine, Episodic Migraine, Headache, Headache, Migraine | 05/24 | 05/24 | | |
OPERA-T, NCT05238116 / 2021-004554-32: Safety and Efficacy of PC945 (Opelconazole) in Combination With Other Antifungal Therapy for the Treatment of Refractory Invasive Pulmonary Aspergillosis ( Study) |
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| Recruiting | 3 | 123 | Europe, Canada, US, RoW | PC945, Placebo | Pulmocide Ltd | Refractory IPA | 03/26 | 04/26 | | |
NCT06004388: Study of Two Digital Therapeutics for the Prevention of Episodic Migraine Receiving CGRP Therapy (ReMMiD-C) |
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| Completed | 3 | 110 | US | Click Digital Therapeutic | Click Therapeutics, Inc. | Migraine, Episodic Migraine, Headache, Headache, Migraine | 05/24 | 06/24 | | |
SKOAP, NCT04504812: A Sequenced Strategy for Improving Outcomes in People With Knee Osteoarthritis Pain |
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| Active, not recruiting | 3 | 1800 | US | Duloxetine, Cymbalta, Intra-Articular Injection, Nerve Procedure with long acting blocks, Nerve Procedure with nerve ablation, Pain Coping Skills Training, Best Practices | Johns Hopkins University, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) | Knee Osteoarthritis | 03/25 | 03/25 | | |
CONVOKE, NCT05838625: Study of Two Digital Therapeutics for the Treatment of Experiential Negative Symptoms of Schizophrenia |
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| Recruiting | 3 | 432 | US | Digital Therapeutic | Click Therapeutics, Inc., Boehringer Ingelheim | Schizophrenia | 06/25 | 07/25 | | |
NCT06067984: An Extension Study of a Second Course of a Digital Therapeutic for the Treatment of Experiential Negative Symptoms of Schizophrenia |
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| Active, not recruiting | 3 | 75 | US | Study App | Click Therapeutics, Inc., Boehringer Ingelheim | Schizophrenia, Negative Symptoms in Schizophrenia | 04/25 | 05/25 | | |
| Active, not recruiting | 2/3 | 1500 | US | ABBV-CLS-7262, DNL343 | Merit E. Cudkowicz, MD, Massachusetts General Hospital | Amyotrophic Lateral Sclerosis | 07/25 | 04/26 | | |
NCT06365437: A Dose Escalation Study of TCD601 Compared to ATG in de Novo Renal Transplantation |
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| Completed | 2 | 33 | Europe | TCD601, Siplizumab, Tacrolimus (TAC), Corticosteroids (CS), Mycophenolate Mofetil (MMF), ATG | ITB-Med LLC | Kidney Transplantation | 12/24 | 12/24 | | |
| Recruiting | 2 | 25 | Europe, Canada, Japan, US, RoW | nedosiran, DCR-PHXC | Dicerna Pharmaceuticals, Inc., a Novo Nordisk company | Primary Hyperoxaluria, Primary Hyperoxaluria Type 1, Primary Hyperoxaluria Type 2, Primary Hyperoxaluria Type 3 | 12/24 | 12/24 | | |
NCT03651700: Transcranial Magnetic Stimulation and Constraint Induced Language Therapy for Chronic Aphasia |
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| Completed | 2 | 86 | US | Active TMS, Sham TMS, CILT, Constraint Induced Language Therapy | H. Branch Coslett, National Institutes of Health (NIH), National Institute on Deafness and Other Communication Disorders (NIDCD) | Aphasia | 08/24 | 08/24 | | |
CHASE, NCT05727878: Trial to Evaluate Safety and Efficacy of KPI-012 Ophthalmic Solution in Participants With PCED |
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| Recruiting | 2 | 90 | US, RoW | KPI-012, KPI-012 Vehicle | Combangio, Inc, Kala Pharmaceuticals, Inc. | Persistent Corneal Epithelial Defect | 03/25 | 10/25 | | |
NCT05733546: A Phase II, Multicentre, Randomised, Double-blind, Controlled Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Efficacy of COMP360 in Participants With Recurrent Major Depressive Disorder |
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| Recruiting | 2 | 102 | US | Psilocybin, COMP360 | COMPASS Pathways | Major Depressive Disorder | 10/24 | 11/24 | | |
NCT04270175: Daratumumab, Pomalidomide, and Dexamethasone (DPd) in Relapsed/Refractory Light Chain Amyloidosis Patients Previously Exposed to Daratumumab |
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| Recruiting | 2 | 21 | US | Daratumumab SC, Faspro, Pomalidomide, Dexamethasone | Weill Medical College of Cornell University, Janssen Scientific Affairs, LLC | Amyloid, AL Amyloidosis, Refractory AL Amyloidosis | 12/25 | 12/29 | | |
NCT04803058: A Study of TCD601 in the Induction of Tolerance in Renal Transplantation (PERSPECTIVE) |
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| Recruiting | 2 | 18 | US, RoW | TCD601 | ITB-Med LLC | Kidney Transplantation | 03/27 | 03/30 | | |
| Not yet recruiting | 2 | 20 | US | Sodium Thiosulfate (STS) | Robyn T. Domsic, MD, MPH, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) | Systemic Sclerosis (SSc), Dermatomyositis, Mixed Connective Tissue Disease (MCTD), Calcinosis | 05/25 | 11/25 | | |
| Active, not recruiting | 2 | 96 | Europe | TCD601, Placebo | ITB-Med LLC | Diabetes Mellitus, Type 1 | 01/25 | 01/25 | | |
| Not yet recruiting | 2 | 30 | Canada | AMT-143 hydrogel containing containing ropivacaine, AMT-143, Ropivacaine, Placebo | AmacaThera Inc. | Hernia, Hernia, Abdominal | 03/26 | 05/26 | | |
| Recruiting | 2 | 90 | US | TCD601, siplizumab, belatacept, ATG, antithymocyte globulin, TAC, tacrolimus, MPA, mycophenolic acid, Corticosteroids | ITB-Med LLC | Renal Transplantation | 07/25 | 10/26 | | |
NCT04311632: A Dose Escalation Study in de Novo Renal Transplantation |
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| Completed | 2 | 13 | US | TCD601, Tacrolimus (TAC), Corticosteroids (CS), Mycophenolate Mofetil (MMF), ATG | ITB-Med LLC | Kidney Transplantation | 10/23 | 10/23 | | |
NCT04464980: Optimizing Retention, Duration and Discontinuation Strategies for Opioid Use Disorder Pharmacotherapy (RDD) |
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| Recruiting | 2 | 2190 | US | SL-BUP, sublingual buprenorphine, Suboxone, XR-BUP, extended-release buprenorphine, CAM2038, Brixadi, XR-NTX, extended-release naltrexone, Vivitrol, MM, MMR, MMD | NYU Langone Health, New York State Psychiatric Institute, Columbia University, Harvard Medical School (HMS and HSDM), Mclean Hospital, National Institute on Drug Abuse (NIDA), The Emmes Company, LLC | Opioid Use Disorder (OUD) | 07/26 | 12/26 | | |
NCT04803006: A Study of TCD601 in the Induction of Tolerance in Renal Transplantation (PANORAMA) |
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| Recruiting | 2 | 18 | US | TCD601 | ITB-Med LLC | Kidney Transplantation | 07/27 | 07/30 | | |
NCT04892251: Ketamine Assisted Psychotherapy for Opioid Use Disorder |
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| Recruiting | 1/2 | 60 | US | MORE+KAP, MORE | University of Utah | Opioid-use Disorder | 12/23 | 05/24 | | |
NCT04482179: Transcranial Magnetic Stimulation and Constraint Induced Language Therapy for Alzheimer Disease |
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| Completed | 1 | 23 | US | Active TMS, CILT, Constraint Induced Language Therapy, Sham TMS | University of Pennsylvania, National Institutes of Health (NIH), National Institute on Deafness and Other Communication Disorders (NIDCD) | Alzheimer Disease | 08/24 | 08/24 | | |
AURORA, NCT06453668: A Study of TCD601 (Siplizumab) in Newly Diagnosed Adult Amyotrophic Lateral Sclerosis (ALS) Patients |
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| Active, not recruiting | 1 | 48 | Europe | TCD601, siplizumab | ITB-Med LLC | ALS | 11/26 | 11/26 | | |
| Recruiting | 1 | 15 | US | PBA-0405, PB004.22.0405.aF | Pure Biologics S.A., Presage Biosciences | Head and Neck Squamous Cell Carcinoma, Soft Tissue Sarcoma Adult, Triple Negative Breast Cancer | 03/25 | 03/25 | | |
MST01-AZN-05, NCT06366451: PBI-MST-01 (NCT04541108) Substudy AZN-05: Intratumoral Microdosing of Rilvegostomig, Volrustomig, and Sabestomig in HNSCC |
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| Recruiting | 1 | 15 | US | Rilvegostomig, AZD2936, Volrustomig, MEDI5752, Sabestomig, AZD7789, Pembrolizumab, Keytruda, MK-3475 | Presage Biosciences, AstraZeneca | Head and Neck Squamous Cell Carcinoma | 12/24 | 03/25 | | |
| Recruiting | 1 | 155 | US, RoW | OP-1250, Ribociclib, KISQALI®, Alpelisib, PIQRAY®, Everolimus | Olema Pharmaceuticals, Inc., Novartis | Metastatic Breast Cancer, Advanced Breast Cancer, ER-positive Breast Cancer, HER2-negative Breast Cancer, Breast Cancer | 05/26 | 06/26 | | |
NCT06798454: Single Ascending Dose Study to Evaluate Safety Tolerability, Pharmacokinetics, and Pharmacodynamics of PVT201 in Healthy Subjects and Patients (PBC/PSC) |
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| Recruiting | 1 | 30 | RoW | PVT201, Navacim, Placebo, normal saline, 0.9% NaCl | Parvus Therapeutics, Inc., Avance Clinical Pty Ltd. | Primary Biliary Cholangitis (PBC) | 02/25 | 02/25 | | |
NCT04541108: Phase 0 Master Protocol for CIVO Intratumoral Microdosing of Anti-Cancer Therapies |
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| Recruiting | 1 | 15 | US | Rilvegostomig, AZD2936, Volrustomig, MEDI5752, Sabestomig, AZD7789, Pembrolizumab, Keytruda, MK-3475 | Presage Biosciences, Merck Sharp & Dohme LLC | Solid Tumor | 12/31 | 12/31 | | |
NCT06802328: Treatment Protocol: Intermediate-Size Patient Population Expanded Access |
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| Available | N/A | | US | Foralumab TZLS-401 50 µg | Tiziana Life Sciences LTD | Non-Active Secondary Progressive Multiple Sclerosis | | | | |
NCT06129084: A Study to Compare the Results of FGFR Testing by Either CtDNA Blood Testing or Standard Tumor Tissue Testing |
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| Recruiting | N/A | 260 | Canada | FGFR Testing | Bernie Eigl, Vancouver Prostate Centre, Lady Davis Institute, Bladder Cancer Canada | Metastatic Bladder Cancer, Metastatic Urothelial Carcinoma | 03/25 | 05/25 | | |
| Completed | N/A | 199 | US | Cigarette flavor type, Experimental cigarette smoking | University of Oklahoma | Smoking, Cigarette | 12/22 | 01/23 | | |
NCT03869463: Computerized Cognitive Training in Young Adults With Depression |
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| Terminated | N/A | 28 | US | Computerized Cognitive Training, Control | Queens College, The City University of New York | Depressive Symptoms | 03/23 | 03/23 | | |
NCT03495011: MRI Characterization of Mammographically Detected DCIS |
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| Active, not recruiting | N/A | 122 | US | Breast MRI, Laboratory Biomarker Analysis, Oncotype Dx | University of Washington, National Cancer Institute (NCI), National Institutes of Health (NIH) | Breast Cancer, Stage 0 | 04/23 | 04/32 | | |
| Recruiting | N/A | 35 | US | MRI, blood draw, Clinical assessments | University of Vermont, National Institute of General Medical Sciences (NIGMS) | Stroke, Acute, Gait, Hemiplegic | 05/23 | 05/23 | | |
NCT04902339: Near-infrared Spectroscopy-based Neurofeedback as Adjunct to Mindfulness-Oriented Recovery Enhancement in Persons With Chronic Pain |
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| Recruiting | N/A | 75 | US | Mindfulness-Oriented Recovery Enhancement, Neurofeedback, Supportive Psychotherapy | University of Utah | Chronic Pain Syndrome, Opioid Use | 05/23 | 08/23 | | |
NCT04088773: Biomarkers of Intestinal Fibrosis in Small Bowel Crohn's Disease |
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| Active, not recruiting | N/A | 232 | US | blood biomarkers, stool biomarkers, MRI imaging | Children's Hospital Medical Center, Cincinnati, The Leona M. and Harry B. Helmsley Charitable Trust | Crohn Disease | 09/23 | 09/24 | | |
NCT06136936: A Study to Evaluate the Overall Effects of Treatment With Abbreviated CT-156 in People With Schizophrenia |
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| Completed | N/A | 53 | US | CT-156-C-001 | Click Therapeutics, Inc., Boehringer Ingelheim | Schizophrenia | 01/24 | 02/24 | | |
| Recruiting | N/A | 20 | US | Prototypes of breast shield and Freedom Double Electric Breast Pump | Momtech Inc. | Healthy, Breast Pumping | 09/24 | 11/24 | | |
NCT06136923: An Exploratory Study to Evaluate Attention Biases in Adults With Multiple Sclerosis, Breast Cancer, and Lung Cancer |
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| Completed | N/A | 194 | US | CT-100-D-004-A, CT-100-D-004-B | Click Therapeutics, Inc. | Multiple Sclerosis, Lung Cancer, Breast Cancer | 04/24 | 05/24 | | |
NCT05465395: Upper Cervical and Thoracic Chiropractic Adjustment |
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| Suspended | N/A | 40 | US | Upper Cervical Adjustemnt, Thoracic Adjustemnt | Life University | Stress | 11/23 | 11/23 | | |
| Completed | N/A | 314 | US | FemaSeed Localized Directional Insemination | Femasys Inc. | Infertility, Male Factor | 12/23 | 04/24 | | |
CT-100-D-003, NCT06275659: An Exploratory Study to Evaluate a Digital Intervention to Disrupt Scratching in Atopic Dermatitis and Psoriasis |
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| Active, not recruiting | N/A | 120 | US | CT-100-004-A, CT-100-004-B | Click Therapeutics, Inc. | Psoriasis, Atopic Dermatitis | 02/24 | 03/24 | | |
NCT05617300: Mindfulness-based Dementia Care Partner Program to Reduce Depressive Symptoms |
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| Completed | N/A | 130 | US | Mindfulness-Based Dementia Caregiving | HealthPartners Institute | Dementia | 12/23 | 03/24 | | |
NCT04685044: Testing a 32-channel Transmit/Receive MRI Head Array |
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| Active, not recruiting | N/A | 15 | Canada | IH 1Tx32Rx Head Array | Lawson Health Research Institute | Magnetic Resonance Imaging | 12/23 | 12/23 | | |
| Completed | N/A | 172 | US | Very low nicotine cigarettes | University of Oklahoma | Cigarette Smoking, Smoking Behaviors | 03/24 | 04/24 | | |
NCT03303248: Evaluation of Web-based Transition Education to Enhance Transition Readiness |
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| Active, not recruiting | N/A | 180 | US | Web-based Educational Intervention | University of Michigan, University of Nebraska | Congenital Heart Disease, Transition, Pediatric Congenital Heart Disease | 03/25 | 03/25 | | |
NCT05119842: APrevent-VOIS-Implant-002 - a Two-Part, Open-Label, Non-Randomized Multicenter Study |
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| Recruiting | N/A | 30 | Europe, US | APrevent® VOIS-Implant | APrevent Biotech GmbH | Paralysis, Unilateral, Vocal Cord | 09/25 | 09/26 | | |
| Completed | N/A | 60 | US | alcohol beverage, Placebo beverage | University of Texas at Austin | Bipolar Disorder, Alcohol Drinking, Alcohol Use Disorder | 03/24 | 03/24 | | |
NCT04625959: Optimizing Mindfulness and Acceptance Based Behavioral Treatment for Bulimia Nervosa and Binge Eating Disorder |
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| Active, not recruiting | N/A | 256 | US | Behavioral Therapy for Eating Disorders, MABT: Mindful Awareness, MABT: Values, MABT: Emotion Modulation, MABT: Distress Tolerance | Drexel University, National Institute of Mental Health (NIMH) | Bulimia Nervosa, Bulimia; Atypical, Binge-Eating Disorder, Binge-Eating and Purging Type Anorexia Nervosa, Binge Eating | 04/24 | 04/24 | | |
NCT06330246: O. Formigenes Colonization in Calcium Oxalate Kidney Stone Disease |
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| Recruiting | N/A | 40 | US | Low oxalate fixed diets pre-colonization, Moderately high oxalate fixed diets pre-colonization, Colonization with Oxalobacter formigenes, Low oxalate fixed diets post-colonization, Moderately high oxalate fixed diets post-colonization | University of Alabama at Birmingham, University of Texas Southwestern Medical Center, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Kidney Stone, Kidney Calculi, Urolithiasis, Urolithiasis, Calcium Oxalate, Nephrolithiasis, Nephrolithiasis, Calcium Oxalate, Oxalate Urolithiasis, Oxaluria | 12/30 | 12/31 | | |
NCT06331546: Gut Oxalate Absorption in Calcium Oxalate Stone Disease |
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| Recruiting | N/A | 80 | US | Low-oxalate diet, High-oxalate diet, soluble oxalate gut absorption test | University of Alabama at Birmingham, University of Texas Southwestern Medical Center, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Kidney Stone, Kidney Calculi, Urolithiasis, Urolithiasis, Calcium Oxalate, Nephrolithiasis, Nephrolithiasis, Calcium Oxalate, Oxalate Urolithiasis, Oxaluria, Healthy | 12/30 | 12/31 | | |
SWAT, NCT06588101: Clinical Trial Recruitment and Retention Strategies for Family Members in the ICU |
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| Recruiting | N/A | 160 | Canada | Written informed consent with infographic, Compensation | Lady Davis Institute, Canadian Institutes of Health Research (CIHR) | Family Members, Recruitment, Clinical Study, Retention, Recruitment of Participants, Study Enrollment, Retention of Participants, Compensation Incentives | 04/25 | 12/25 | | |
NCT06431386: Behavioural Activation Therapy and Esketamine for Resistant Depression |
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| Recruiting | N/A | 40 | Canada | Behavioural Activation (BA) Therapy, Esketamine | The Royal's Institute of Mental Health Research | Depressive Disorder, Treatment-Resistant, Depressive Disorder, Major, Bipolar Disorder | 08/26 | 08/26 | | |
| Completed | N/A | 68 | US | Alcohol beverage, Placebo beverage | University of Texas at Austin | Bipolar Disorder, Alcohol Drinking, Alcohol Use Disorder | 06/24 | 06/24 | | |
NCT04279483: GeoScan and Remote Geo Smoking Study: Neural and Behavioral Correlates of Smokers' Exposure to Retail Environments |
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| Completed | N/A | 336 | US | 7-11, CVS | Abramson Cancer Center at Penn Medicine, National Cancer Institute (NCI), New York University, Stanford University | Smoking, Tobacco, Smoking, Smoking, Cigarette | 06/24 | 06/24 | | |
