| Rose, David D |
| Active, not recruiting | 3 | 514 | US | Argatroban, Eptifibatide, Placebo | Washington University School of Medicine, National Institute of Neurological Disorders and Stroke (NINDS) | Acute Ischemic Stroke | 12/23 | 04/25 | | |
| Recruiting | 2/3 | 728 | US | Recombinant human tissue kallikrein, DM199, Placebo for DM199 Solution for Injection | DiaMedica Therapeutics Inc | Acute Stroke, Ischemic Stroke, Stroke | 12/26 | 12/26 | | |
NCT05889546: Rapid Autopsy Protocol for Patients with Small Cell Lung Cancer |
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| Recruiting | N/A | 10 | US | Biospecimen Collection | Indiana University | Small Cell Lung Cancer | 12/25 | 12/26 | | |
| Torbey, Michel |
NCT02864953 / 2017-004854-41: Phase 3 Study to Evaluate the Efficacy and Safety of Intravenous BIIB093 (Glibenclamide) for Severe Cerebral Edema Following Large Hemispheric Infarction |
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| Terminated | 3 | 535 | Europe, Canada, Japan, US, RoW | BIIB093, glibenclamide, glibenclamide intravenous (IV), glyburide, CIRARA, Placebo | Remedy Pharmaceuticals, Inc. | Brain Edema, Stroke, Acute | 08/23 | 08/23 | | |
| Recruiting | 2/3 | 728 | US | Recombinant human tissue kallikrein, DM199, Placebo for DM199 Solution for Injection | DiaMedica Therapeutics Inc | Acute Stroke, Ischemic Stroke, Stroke | 12/26 | 12/26 | | |
NCT05298709: Functional Magnetic Resonance Imaging (fMRI) Vascular Reactivity in Cerebral Cavernous Malformations (CCM) |
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| Recruiting | N/A | 15 | US | Hyperventilation and CO2 challenge | University of New Mexico, University of California, San Francisco | Cerebral Cavernous Malformation | 03/25 | 06/25 | | |
NCT01764529: Modifiers of Disease Severity in Cerebral Cavernous Malformations |
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| Recruiting | N/A | 800 | US | | University of California, San Francisco, University of New Mexico, University of Chicago, National Institute of Neurological Disorders and Stroke (NINDS), Boston Children's Hospital, Children's Hospital Medical Center, Cincinnati, Barrow Neurological Institute, Alliance to Cure Cavernous Malformation | Cavernous Angioma, Familial, Cerebral Cavernous Malformations, Cerebral Cavernous Hemangioma | 06/25 | 06/25 | | |
| Recruiting | N/A | 3062 | US | CPAP | University of Michigan, National Institute of Neurological Disorders and Stroke (NINDS), FusionHealth LLC, Medical University of South Carolina, University of Cincinnati | Ischemic Stroke, Sleep Apnea, Sleep Apnea, Obstructive, Stroke, CPAP, Telemedicine, Home Sleep Apnea Test, Randomized Clinical Trial, Multicenter Trial | 11/26 | 11/26 | | |
| Concha, Mauricio |
| Active, not recruiting | 3 | 514 | US | Argatroban, Eptifibatide, Placebo | Washington University School of Medicine, National Institute of Neurological Disorders and Stroke (NINDS) | Acute Ischemic Stroke | 12/23 | 04/25 | | |
| Completed | 3 | 226 | Europe, Canada, US, RoW | Bentracimab (PB2452) Infusion | SFJ Pharmaceuticals, Inc. | Hemorrhage, Urgent Surgery, Invasive Procedure | 09/24 | 09/24 | | |
| Active, not recruiting | 3 | 1083 | Canada, US, RoW | Simufilam, PTI-125, Placebo | Cassava Sciences, Inc., Premier Research Group plc | Alzheimer Disease | 05/25 | 05/25 | | |
CAPTIVA, NCT05047172: Comparison of Anti-coagulation and Anti-Platelet Therapies for Intracranial Vascular Atherostenosis |
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| Recruiting | 3 | 1683 | US | Ticagrelor + Aspirin, Brilinta, Rivaroxaban + Aspirin, Xarelto, Clopidogrel + Aspirin, Plavix, Risk Factor Management | University of Florida, National Institute of Neurological Disorders and Stroke (NINDS), University of Cincinnati, Medical University of South Carolina, Janssen Scientific Affairs, LLC, AstraZeneca | Intracranial Arteriosclerosis, Stroke | 05/28 | 05/28 | | |
| Recruiting | 2/3 | 728 | US | Recombinant human tissue kallikrein, DM199, Placebo for DM199 Solution for Injection | DiaMedica Therapeutics Inc | Acute Stroke, Ischemic Stroke, Stroke | 12/26 | 12/26 | | |
NCT06538116: A Study of Mevidalen (LY3154207) in Participants With Alzheimer's Disease |
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| Recruiting | 2 | 300 | Japan, US | Mevidalen, LY3154207, Placebo | Eli Lilly and Company | Alzheimer Disease | 12/25 | 01/26 | | |
| Recruiting | N/A | 3062 | US | CPAP | University of Michigan, National Institute of Neurological Disorders and Stroke (NINDS), FusionHealth LLC, Medical University of South Carolina, University of Cincinnati | Ischemic Stroke, Sleep Apnea, Sleep Apnea, Obstructive, Stroke, CPAP, Telemedicine, Home Sleep Apnea Test, Randomized Clinical Trial, Multicenter Trial | 11/26 | 11/26 | | |
| Gordon, Errol |
NCT02864953 / 2017-004854-41: Phase 3 Study to Evaluate the Efficacy and Safety of Intravenous BIIB093 (Glibenclamide) for Severe Cerebral Edema Following Large Hemispheric Infarction |
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| Terminated | 3 | 535 | Europe, Canada, Japan, US, RoW | BIIB093, glibenclamide, glibenclamide intravenous (IV), glyburide, CIRARA, Placebo | Remedy Pharmaceuticals, Inc. | Brain Edema, Stroke, Acute | 08/23 | 08/23 | | |
| Active, not recruiting | 3 | 514 | US | Argatroban, Eptifibatide, Placebo | Washington University School of Medicine, National Institute of Neurological Disorders and Stroke (NINDS) | Acute Ischemic Stroke | 12/23 | 04/25 | | |
| Recruiting | 3 | 860 | Europe, Canada, Japan, US | Recombinant Activated Factor VII (rFVIIa), NovoSeven, NiaStase, Placebo | Joseph Broderick, MD, Novo Nordisk A/S, National Institute of Neurological Disorders and Stroke (NINDS) | Intracerebral Hemorrhage | 01/28 | 01/28 | | |
| Recruiting | 2/3 | 728 | US | Recombinant human tissue kallikrein, DM199, Placebo for DM199 Solution for Injection | DiaMedica Therapeutics Inc | Acute Stroke, Ischemic Stroke, Stroke | 12/26 | 12/26 | | |
| Casanova, Teresita |
| Recruiting | 2/3 | 728 | US | Recombinant human tissue kallikrein, DM199, Placebo for DM199 Solution for Injection | DiaMedica Therapeutics Inc | Acute Stroke, Ischemic Stroke, Stroke | 12/26 | 12/26 | | |
