| Rose, David D |
| Recruiting | 2/3 | 728 | US | Recombinant human tissue kallikrein, DM199, Placebo for DM199 Solution for Injection | DiaMedica Therapeutics Inc | Acute Stroke, Ischemic Stroke, Stroke | 12/26 | 12/26 | | |
| Torbey, Michel |
NCT02864953 / 2017-004854-41: Phase 3 Study to Evaluate the Efficacy and Safety of Intravenous BIIB093 (Glibenclamide) for Severe Cerebral Edema Following Large Hemispheric Infarction |
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| Terminated | 3 | 535 | Europe, Canada, Japan, US, RoW | BIIB093, glibenclamide, glibenclamide intravenous (IV), glyburide, CIRARA, Placebo | Remedy Pharmaceuticals, Inc. | Brain Edema, Stroke, Acute | 08/23 | 08/23 | | |
| Recruiting | 2/3 | 728 | US | Recombinant human tissue kallikrein, DM199, Placebo for DM199 Solution for Injection | DiaMedica Therapeutics Inc | Acute Stroke, Ischemic Stroke, Stroke | 12/26 | 12/26 | | |
| Concha, Mauricio |
| Completed | 3 | 226 | Europe, Canada, US, RoW | Bentracimab (PB2452) Infusion | SFJ Pharmaceuticals, Inc. | Hemorrhage, Urgent Surgery, Invasive Procedure | 09/24 | 09/24 | | |
| Active, not recruiting | 3 | 1083 | Canada, US, RoW | Simufilam, PTI-125, Placebo | Cassava Sciences, Inc., Premier Research Group plc | Alzheimer Disease | 05/25 | 05/25 | | |
CAPTIVA, NCT05047172: Comparison of Anti-coagulation and Anti-Platelet Therapies for Intracranial Vascular Atherostenosis |
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| Recruiting | 3 | 1683 | US | Ticagrelor + Aspirin, Brilinta, Rivaroxaban + Aspirin, Xarelto, Clopidogrel + Aspirin, Plavix, Risk Factor Management | University of Florida, National Institute of Neurological Disorders and Stroke (NINDS), University of Cincinnati, Medical University of South Carolina, Janssen Scientific Affairs, LLC, AstraZeneca | Intracranial Arteriosclerosis, Stroke | 05/28 | 05/28 | | |
| Recruiting | 2/3 | 728 | US | Recombinant human tissue kallikrein, DM199, Placebo for DM199 Solution for Injection | DiaMedica Therapeutics Inc | Acute Stroke, Ischemic Stroke, Stroke | 12/26 | 12/26 | | |
NCT06538116: A Study of Mevidalen (LY3154207) in Participants With Alzheimer's Disease |
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| Recruiting | 2 | 300 | Japan, US | Mevidalen, LY3154207, Placebo | Eli Lilly and Company | Alzheimer Disease | 12/25 | 01/26 | | |
| Gordon, Errol |
NCT02864953 / 2017-004854-41: Phase 3 Study to Evaluate the Efficacy and Safety of Intravenous BIIB093 (Glibenclamide) for Severe Cerebral Edema Following Large Hemispheric Infarction |
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| Terminated | 3 | 535 | Europe, Canada, Japan, US, RoW | BIIB093, glibenclamide, glibenclamide intravenous (IV), glyburide, CIRARA, Placebo | Remedy Pharmaceuticals, Inc. | Brain Edema, Stroke, Acute | 08/23 | 08/23 | | |
| Recruiting | 3 | 860 | Europe, Canada, Japan, US | Recombinant Activated Factor VII (rFVIIa), NovoSeven, NiaStase, Placebo | Joseph Broderick, MD, Novo Nordisk A/S, National Institute of Neurological Disorders and Stroke (NINDS) | Intracerebral Hemorrhage | 01/28 | 01/28 | | |
| Recruiting | 2/3 | 728 | US | Recombinant human tissue kallikrein, DM199, Placebo for DM199 Solution for Injection | DiaMedica Therapeutics Inc | Acute Stroke, Ischemic Stroke, Stroke | 12/26 | 12/26 | | |
| Casanova, Teresita |
| Recruiting | 2/3 | 728 | US | Recombinant human tissue kallikrein, DM199, Placebo for DM199 Solution for Injection | DiaMedica Therapeutics Inc | Acute Stroke, Ischemic Stroke, Stroke | 12/26 | 12/26 | | |
