University of Maryland School of Medicine
Welcome,         Profile    Billing    Logout  
 157 Trials 
949 Trials

   

 
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Mehta, Minesh P
METIS, NCT02831959: Pivotal, Open-label, Randomized Study of Radiosurgery with or Without Tumor Treating Fields (TTFields) for 1-10 Brain Metastases from Non-small Cell Lung Cancer (NSCLC).

Completed
3
298
Europe, Canada, US, RoW
NovoTTF-200M device, Best Standard of Care
NovoCure GmbH
Brain Metastases from Non-small Cell Lung Cancer (NSCLC)
11/24
11/24
NRG-BN001, NCT02163135: Dose-Escalated Photon IMRT or Proton Beam Radiation Therapy Versus Standard-Dose Radiation Therapy and Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma

Not yet recruiting
2
576
US
3-dimensional conformal radiation therapy, 3D conformal radiation therapy, 3D-CRT, intensity-modulated radiation therapy, IMRT, photon beam radiation therapy, proton beam radiation therapy, temozolomide, SCH 52365, Temodal, Temodar, TMZ, laboratory biomarker analysis
Radiation Therapy Oncology Group, National Cancer Institute (NCI), NRG Oncology Foundation
Adult Giant Cell Glioblastoma, Adult Glioblastoma, Adult Gliosarcoma
05/19
 
NCT04466683: Low-Dose Radiotherapy For Patients With SARS-COV-2 (COVID-19) Pneumonia

Active, not recruiting
2
37
US, RoW
Low dose radiation 35 cGy, High dose radiation 100 cGy
Ohio State University Comprehensive Cancer Center, Varian Medical Systems
Covid-19, Sars-CoV2, Pneumonia
12/24
12/25
NCT02847559: Optune Delivered Electric Field Therapy and Bevacizumab in Treating Patients With Recurrent or Progressive Grade 2 or 3 Meningioma

Recruiting
2
27
US
Bevacizumab, Anti-VEGF, Anti-VEGF Humanized Monoclonal Antibody, Anti-VEGF rhuMAb, Avastin, Bevacizumab Biosimilar BEVZ92, Bevacizumab Biosimilar BI 695502, Immunoglobulin G1 (Human-Mouse Monoclonal rhuMab-VEGF Gamma-Chain Anti-Human Vascular Endothelial Growth Factor), Disulfide With Human-Mouse Monoclonal rhuMab-VEGF Light Chain, Dimer, Recombinant Humanized Anti-VEGF Monoclonal Antibody, rhuMab-VEGF, Electric Field Therapy, NovoTTF-200A Device, NovoTTF-200A, NovoTTF-200A System, NovoTTFields, NovoTumor Treatment Fields, Optune, Optune Device, Quality-of-Life Assessment, Quality of Life Assessment
Northwestern University, NovoCure Ltd., National Cancer Institute (NCI)
Anaplastic (Malignant) Meningioma, Atypical Meningioma, Grade II Meningioma, Grade III Meningioma, Recurrent Meningioma, Supratentorial Meningioma
09/26
12/26
NRG-BN001, NCT02179086: Dose-Escalated Photon IMRT or Proton Beam Radiation Therapy Versus Standard-Dose Radiation Therapy and Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma

Active, not recruiting
2
624
Canada, US
3-dimensional conformal radiation therapy, 3D conformal radiation therapy, 3D-CRT, intensity-modulated radiation therapy, IMRT, photon beam radiation therapy, proton beam radiation therapy, temozolomide, SCH 52365, Temodal, Temodar, TMZ, laboratory biomarker analysis
NRG Oncology, National Cancer Institute (NCI), Radiation Therapy Oncology Group
Adult Giant Cell Glioblastoma, Adult Glioblastoma, Adult Gliosarcoma
12/25
12/26
ADORATION, NCT05789589: Effect of Azeliragon Combined With Stereotactic Radiation Therapy in Patients With Brain Metastases

Recruiting
1/2
46
US
Azeliragon, TTP488, PF-04494700, Stereotactic radiosurgery, Corticosteroid, dexamethasone, methylprednisolone
Baptist Health South Florida, Miami Cancer Institute, Cantex Pharmaceuticals Inc.
Cancer, Metastasis, Metastatic Cancer, Brain Metastases, Brain Metastases, Adult
10/25
08/27
Edelman, Martin J
ACCIO, NCT04267848: Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-Small Cell Lung Cancer, ALCHEMIST Trial

Recruiting
3
1210
US, RoW
Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Carboplatin, Blastocarb, Carboplat, Carboplatin Hexal, Carboplatino, Carboplatinum, Carbosin, Carbosol, Carbotec, CBDCA, Displata, Ercar, JM-8, JM8, Nealorin, Novoplatinum, Paraplatin, Paraplatin AQ, Paraplatine, Platinwas, Ribocarbo, Cisplatin, Abiplatin, Blastolem, Briplatin, CDDP, Cis-diammine-dichloroplatinum, Cis-diamminedichloridoplatinum, Cis-diamminedichloro Platinum (II), Cis-diamminedichloroplatinum, Cis-dichloroammine Platinum (II), Cis-platinous Diamine Dichloride, Cis-platinum, Cis-platinum II, Cis-platinum II Diamine Dichloride, Cismaplat, Cisplatina, Cisplatinum, Cisplatyl, Citoplatino, Citosin, Cysplatyna, DDP, Lederplatin, Metaplatin, Neoplatin, Peyrone's Chloride, Peyrone's Salt, Placis, Plastistil, Platamine, Platiblastin, Platiblastin-S, Platinex, Platinol, Platinol- AQ, Platinol-AQ, Platinol-AQ VHA Plus, Platinoxan, Platinum, Platinum Diamminodichloride, Platiran, Platistin, Platosin, Computed Tomography, CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, Computerized Tomography (CT) scan, CT, CT Scan, tomography, Echocardiography, EC, Gemcitabine Hydrochloride, dFdCyd, Difluorodeoxycytidine Hydrochloride, Gemcitabine HCI, Gemzar, LY 188011, LY-188011, LY188011, Magnetic Resonance Imaging, Magnetic Resonance, Magnetic Resonance Imaging (MRI), Magnetic resonance imaging (procedure), Magnetic Resonance Imaging Scan, Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance, MR, MR Imaging, MRI, MRI Scan, MRIs, NMR Imaging, NMRI, Nuclear Magnetic Resonance Imaging, sMRI, Structural MRI, Observation, Inspection, Visual Inspection, Paclitaxel, Anzatax, Asotax, Bristaxol, Praxel, Taxol, Taxol Konzentrat, Pembrolizumab, BCD-201, GME 751, GME751, Keytruda, Lambrolizumab, MK 3475, MK-3475, MK3475, Pembrolizumab Biosimilar BCD-201, Pembrolizumab Biosimilar GME751, Pembrolizumab Biosimilar QL2107, Pembrolizumab Biosimilar RPH-075, QL2107, RPH 075, RPH-075, RPH075, SCH 900475, SCH-900475, SCH900475, Pemetrexed Disodium, Alimta, Almita, LY231514, N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid Disodium Salt, Questionnaire Administration
National Cancer Institute (NCI)
Lung Non-Small Cell Carcinoma, Lung Non-Small Cell Squamous Carcinoma, Lung Non-Squamous Non-Small Cell Carcinoma, Stage II Lung Cancer AJCC v8, Stage IIIA Lung Cancer AJCC v8, Stage IIIB Lung Cancer AJCC v8
12/25
12/25
RAMP-202, NCT04620330 / 2020-004265-39: A Study of Avutometinib (VS-6766) + Defactinib in Recurrent KRAS G12V, Other KRAS and BRAF Non-Small Cell Lung Cancer

Checkmark Trial initiated for LGSOC and KRAS mutated NSCLC
Dec 2020 - Dec 2020: Trial initiated for LGSOC and KRAS mutated NSCLC
Completed
2
90
Europe, US
avutometinib (VS-6766), avutometinib (VS-6766) and Defactinib, avutometinib (VS-6766) and VS-6063
Verastem, Inc.
Non Small Cell Lung Cancer, KRAS Activating Mutation
08/23
12/23
S1701, NCT03694002: Carboplatin and Paclitaxel With or Without Ramucirumab in Treating Patients With Locally Advanced, Recurrent, or Metastatic Thymic Cancer That Cannot Be Removed by Surgery

Active, not recruiting
2
66
US
Carboplatin, Blastocarb, Carboplat, Carboplatin Hexal, Carboplatino, Carboplatinum, Carbosin, Carbosol, Carbotec, CBDCA, Displata, Ercar, JM-8, Nealorin, Novoplatinum, Paraplatin, Paraplatin AQ, Paraplatine, Platinwas, Ribocarbo, Paclitaxel, Anzatax, Asotax, Bristaxol, Praxel, Taxol, Taxol Konzentrat, Ramucirumab, Anti-VEGFR-2 Fully Human Monoclonal Antibody IMC-1121B, Cyramza, IMC-1121B, LY3009806, Monoclonal Antibody HGS-ETR2
SWOG Cancer Research Network, National Cancer Institute (NCI)
Locally Advanced Thymic Carcinoma, Metastatic Thymic Carcinoma, Recurrent Thymic Carcinoma, Unresectable Thymic Carcinoma
03/25
06/25
MAGE, NCT00704041: Four Doses of Vaccine for Patients With Squamous Cell Carcinoma of the Head and Neck

Recruiting
1
48
US
MAGE-A3 HPV-16 vaccine, MAGE-A3/HPV 16 Trojan Peptides 0001 and 0002
University of Maryland, National Institutes of Health (NIH)
Squamous Cell Carcinoma, Head and Neck Cancer
06/10
06/12
NCT03391778 / 2018-004888-31: Adoptive Cell Therapy Long-term Follow-up (LTFU) Study

Recruiting
1
250
Europe, Canada, US, RoW
ADP adoptive cell therapy
Adaptimmune
Neoplasms
04/32
04/32
NCT06222242: mychoiceTM Implementation With Medical Oncology Patients

Recruiting
N/A
200
US
mychoiceTM
Fox Chase Cancer Center, Genentech, Inc.
Cancer
06/25
06/25
NCT03992183: Utility of CAML as Diagnostic for Early Stage Lung Cancer

Active, not recruiting
N/A
200
US
Fox Chase Cancer Center, United States Department of Defense, Creatv Microtech, Inc.
Pulmonary Nodule, Multiple, Pulmonary Nodule, Solitary
03/25
03/25
ALCHEMIST Screening, NCT02194738: Genetic Testing in Screening Patients With Stage IB-IIIA Non-small Cell Lung Cancer That Has Been or Will Be Removed by Surgery (The Trial)

Recruiting
N/A
8300
US, RoW
Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Carboplatin, Blastocarb, Carboplat, Carboplatin Hexal, Carboplatino, Carboplatinum, Carbosin, Carbosol, Carbotec, CBDCA, Displata, Ercar, JM-8, JM8, Nealorin, Novoplatinum, Paraplatin, Paraplatin AQ, Paraplatine, Platinwas, Ribocarbo, Cisplatin, Abiplatin, Blastolem, Briplatin, CDDP, Cis-diammine-dichloroplatinum, Cis-diamminedichloridoplatinum, Cis-diamminedichloro Platinum (II), Cis-diamminedichloroplatinum, Cis-dichloroammine Platinum (II), Cis-platinous Diamine Dichloride, Cis-platinum, Cis-platinum II, Cis-platinum II Diamine Dichloride, Cismaplat, Cisplatina, Cisplatinum, Cisplatyl, Citoplatino, Citosin, Cysplatyna, DDP, Lederplatin, Metaplatin, Neoplatin, Peyrone's Chloride, Peyrone's Salt, Placis, Plastistil, Platamine, Platiblastin, Platiblastin-S, Platinex, Platinol, Platinol- AQ, Platinol-AQ, Platinol-AQ VHA Plus, Platinoxan, Platinum, Platinum Diamminodichloride, Platiran, Platistin, Platosin, Clinical Observation, observation, Computed Tomography, CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, Computerized Tomography (CT) scan, CT, CT Scan, tomography, Crizotinib, Alkixen, Crizocent, MET Tyrosine Kinase Inhibitor PF-02341066, PF 02341066, PF-02341066, PF-2341066, PF02341066, Xalkori, Cytology Specimen Collection Procedure, Cytologic Sampling, Echocardiography, EC, Erlotinib, Gemcitabine Hydrochloride, dFdCyd, Difluorodeoxycytidine Hydrochloride, Gemcitabine HCI, Gemzar, LY 188011, LY-188011, LY188011, Nivolumab, ABP 206, BCD-263, BMS 936558, BMS-936558, BMS936558, CMAB819, MDX 1106, MDX-1106, MDX1106, NIVO, Nivolumab Biosimilar ABP 206, Nivolumab Biosimilar BCD-263, Nivolumab Biosimilar CMAB819, ONO 4538, ONO-4538, ONO4538, Opdivo, Paclitaxel, Anzatax, Asotax, Bristaxol, Praxel, Taxol, Taxol Konzentrat, Pembrolizumab, BCD-201, GME 751, GME751, Keytruda, Lambrolizumab, MK 3475, MK-3475, MK3475, Pembrolizumab Biosimilar BCD-201, Pembrolizumab Biosimilar GME751, Pembrolizumab Biosimilar QL2107, Pembrolizumab Biosimilar RPH-075, QL2107, RPH 075, RPH-075, RPH075, SCH 900475, SCH-900475, SCH900475, Pemetrexed, MTA, Multitargeted Antifolate, Pemfexy, Pemetrexed Disodium, Alimta, Almita, LY231514, N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid Disodium Salt, Placebo Administration, Positron Emission Tomography, Medical Imaging, Positron Emission Tomography, PET, PET Scan, Positron emission tomography (procedure), Positron Emission Tomography Scan, Positron-Emission Tomography, proton magnetic resonance spectroscopic imaging, PT
National Cancer Institute (NCI)
Stage IB Lung Non-Small Cell Carcinoma AJCC v7, Stage II Lung Non-Small Cell Cancer AJCC v7, Stage IIA Lung Cancer AJCC v8, Stage IIB Lung Cancer AJCC v8, Stage IIIA Lung Cancer AJCC v8, Stage IIIA Lung Non-Small Cell Cancer AJCC v7, Stage IIIB Lung Cancer AJCC v8
09/26
09/26
Kelly, Deanna L
REVISIT C, NCT05208190: Clozapine for the Prevention of Violence in Schizophrenia: a Randomized Clinical Trial

Recruiting
4
280
US
Clozapine, clozaril, treatment as usual
New York State Psychiatric Institute, National Institute of Mental Health (NIMH)
Schizophrenia, Schizoaffective Disorder
01/27
02/27
NCT03183609: Confirmatory Efficacy Trial of a Gluten-Free Diet in a Subgroup of Persons With Schizophrenia Who Have High Levels of IgG Anti-Gliadin Antibodies (AGA IG)

Completed
N/A
40
US
Gluten Flour in Protein Shake, Rice Flour in Protein Shake
University of Maryland, Baltimore
Schizophrenia, Gluten Sensitivity, Schizo Affective Disorder
03/24
03/24
NCT05968638: Ketogenic Diet in People With Schizophrenia

Active, not recruiting
N/A
50
US
Regular Diet, Ketogenic Diet
University of Maryland, Baltimore
Schizophrenia, Schizo Affective Disorder
08/26
08/27
Harrop, James S
3STLIF, NCT04823858: 3Spine Lumbar Fusion Real World Evidence Study

Recruiting
N/A
200
US
Lumbar Interbody Fusion
3Spine, MCRA
Lumbar Spine Degeneration
05/24
08/26
NCT02991690: Systemic Hypothermia in Acute Cervical Spinal Cord Injury

Recruiting
N/A
120
US
Hypothermia
University of Miami, United States Department of Defense
Spinal Cord Injury, Acute
08/25
09/25
NCT05653206: Incomplete Cervical SCI Without Instability

Recruiting
N/A
50
Europe, Canada, US, RoW
Nonsurgical treatment, Surgical treatment
AO Foundation, AO Spine
Cervical Spinal Cord Injury
05/26
08/27
NACTN, NCT00178724: Spinal Cord Injury Registry - North American Clinical Trials Network

Recruiting
N/A
1500
Canada, US
No Treatment Given
Robert G. Grossman, MD, Christopher Reeve Paralysis Foundation, The Methodist Hospital Research Institute, The University of Texas Health Science Center, Houston, University of Virginia, University of Louisville, University of Toronto, University of Maryland, Baltimore, Walter Reed National Military Medical Center, Thomas Jefferson University, University of Miami, Brooke Army Medical Center, Louisiana State University Health Sciences Center in New Orleans, Vanderbilt University Medical Center, Medical College of Wisconsin, Duke University
Spinal Cord Injury
07/25
07/28
Halloran, Philip
INTERLUNG, NCT02812290: Diagnostic and Therapeutic Applications of Microarrays in Lung Transplantation

Recruiting
N/A
700
Europe, Canada, US, RoW
Lung transplant biopsy bites.
University of Alberta
Lung Transplant Rejection
11/25
06/26
NCT05837663: Trifecta-Lung cfDNA-MMDx Study

Recruiting
N/A
600
Europe, Canada, US, RoW
University of Alberta, Natera, Inc., One Lambda
Lung Transplantation
11/26
12/27
NCT01299168: Diagnostic and Therapeutic Applications in Microarrays in Organ Transplantation

Recruiting
N/A
500
Europe, Canada, US, RoW
University of Alberta
Validation Study of Molecular Diagnostic System, Development of Reporting System for Molecular Diagnosis, Incorporate Molecular Diagnosis Into Diagnostic Standards
12/25
06/26
NCT02670408: Diagnostic and Therapeutic Applications of Microarrays in Heart Transplantation

Recruiting
N/A
900
Europe, Canada, US, RoW
Endomyocardial biopsy
University of Alberta
Cardiac Transplant Disorder
12/25
07/26
INTERLIVER, NCT03193151: Diagnostic and Therapeutic Applications of Microarrays in Liver Transplantation

Recruiting
N/A
300
Europe, Canada, US, RoW
liver biopsy
University of Alberta
Liver Dysfunction
12/25
12/26
NCT04239703: Trifecta-Kidney cfDNA-MMDx Study

Recruiting
N/A
300
Europe, Canada, US, RoW
MMDx, Prospera, transplant patient blood sample, HLA antibody
University of Alberta, Natera, Inc., One Lambda
Kidney Transplant Rejection
12/25
12/26
NCT04707872: Trifecta-Heart cfDNA-MMDx Study

Recruiting
N/A
300
Europe, Canada, US, RoW
MMDx diagnostic test, Prospera, HLA antibody
University of Alberta, Natera, Inc., One Lambda
Heart Transplant Rejection
12/26
07/27
Powers, Scott W
NCT03472092: Mind and Body Approaches to Pain Reduction in Youth With Migraine

Active, not recruiting
2
132
US
Cognitive Behavioral Therapy (CBT), CBT, coping skills, mind body relaxation, Placebo, Placebo Oral Capsule, Amitriptyline, Elavil, Biofeedback-Assisted Relaxation Training (BART), Cognitive Reappraisal Training (CR)
Children's Hospital Medical Center, Cincinnati, National Institute of Neurological Disorders and Stroke (NINDS), National Center for Complementary and Integrative Health (NCCIH)
Headache, Migraine, Migraine, Migraine Disorders, Headache
03/25
06/25
NCT04567355: Migraine Manager (R01)

Recruiting
2
160
US
Migraine Manager
Children's Hospital Medical Center, Cincinnati
Migraine, Migraine Disorders
04/25
05/25
NCT04715685: Mind Body Balance for Pediatric Migraine

Recruiting
N/A
260
US
40 minute session, 20 minute session, home practice e-health, home practice handout, phone call
Children's Hospital Medical Center, Cincinnati, National Center for Complementary and Integrative Health (NCCIH)
Headache, Headache Disorders, Headache, Migraine, Migraine, Migraine Disorders, Migraine With Aura, Migraine Without Aura, Chronic Migraine
05/26
08/26
NCT05987592: BE WELL With Migraine: Brain Education and WELLness With Migraine

Recruiting
N/A
286
US
Brain Education and WELLness with Migraine Group A, Migraine Group A, Brain Education and WELLness with Migraine Group B, Migraine Group B
Wake Forest University Health Sciences, National Center for Complementary and Integrative Health (NCCIH)
Migraine
09/26
09/26
NCT05889624: Responding With Evidence and Access for Childhood Headaches

Recruiting
N/A
400
US
CBT, Cognitive Behavioral Therapy, Amitriptyline
Children's Hospital Medical Center, Cincinnati, Patient-Centered Outcomes Research Institute
Headache, Headache Disorders, Headache, Migraine, Migraine, Migraine Disorders, Migraine With Aura, Migraine Without Aura, Chronic Migraine
07/27
12/27
Hafer-Macko, Charlene
NCT01302197: Muscle Atrophy, Physical Performance and Glucose Tolerance Post Stroke

Active, not recruiting
N/A
100
US
No intervention
Baltimore VA Medical Center
Stroke
12/25
06/26
NCT03530592: Seated Ankle Robot for Foot Drop in Aging and Disabled Populations: A Demonstration Project

Not yet recruiting
N/A
100
US
Seated Ankle Robot Training
Baltimore VA Medical Center
Peripheral Nervous System Diseases, Gait Disorders, Neurologic, Foot Drop, Mobility Limitation
12/28
12/28
NCT03556709: Walking Ankle Robot for Foot Drop in Aging and Disabled Populations: A Demonstration Project

Not yet recruiting
N/A
100
NA
Treadmill Ankle Robot Training
Baltimore VA Medical Center
Foot Drop, Peripheral Nervous System Diseases, Gait Disorders, Neurologic, Mobility Limitation
12/28
12/28
Rolfo, Christian
NCT03810872: An Explorative Study of Afatinib in the Treatment of Advanced Cancer Carrying an EGFR, a HER2 or a HER3 Mutation

Recruiting
2
87
Europe
Afatinib, Paclitaxel
AZ-VUB
Cancers Harbouring an EGFR Mutation, (Excluding Non-squamous Non- Small Cell Lung Cancer, a Registered Indication), a HER2 Mutation or a HER3 Mutation
12/20
12/22
LUNG-MAP SUB-STUDY, NCT06116682: Targeted Treatment for Advanced Non-Small Cell Lung Cancer That Has Increased Copies of the MET Gene (An Expanded Lung-MAP Treatment Trial)

Recruiting
2
88
US
Amivantamab, Amivantamab-vmjw, Anti-EGFR/c-Met Bispecific Antibody JNJ-61186372, CNTO-4424, JNJ 61186372, JNJ-611, JNJ-61186372, JNJ61186372, Rybrevant, Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Computed Tomography, CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, Computerized Tomography (CT) scan, CT, CT Scan, tomography, Magnetic Resonance Imaging, Magnetic Resonance, Magnetic Resonance Imaging (MRI), Magnetic resonance imaging (procedure), Magnetic Resonance Imaging Scan, Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance, MR, MR Imaging, MRI, MRI Scan, MRIs, NMR Imaging, NMRI, Nuclear Magnetic Resonance Imaging, sMRI, Structural MRI
SWOG Cancer Research Network, National Cancer Institute (NCI)
Lung Non-Small Cell Carcinoma
05/28
05/28
NCT05119933: A Phase 1/2, Study of YL-15293 in Subjects With Advanced Solid Tumors With a KRAS G12C Mutation

Recruiting
1/2
55
US
YL-15293
Shanghai YingLi Pharmaceutical Co. Ltd., Yingli Pharma US, Inc
Advanced Solid Tumor
06/23
12/23
LIBRETTO-001, NCT03157128 / 2017-000800-59: A Study of Selpercatinib (LOXO-292) in Participants With Advanced Solid Tumors, RET Fusion-Positive Solid Tumors, and Medullary Thyroid Cancer

Hourglass Apr 2022 - Dec 2022 : Approval in China for RET+NSCLC, medullary thyroid cancer and thyroid cancer
Hourglass Jan 2022 - Dec 2022 : Submission for lung cancer
Checkmark From LIBRETTO-001 trial in RET fusion-positive NSCLC
Aug 2020 - Aug 2020: From LIBRETTO-001 trial in RET fusion-positive NSCLC
Checkmark Granted for advanced RET fusion+ve 2L thyroid cancer [LIBRETTO-001]
More
Active, not recruiting
1/2
856
Europe, Canada, Japan, US, RoW
LOXO-292, Selpercatinib, LY3527723
Loxo Oncology, Inc., Eli Lilly and Company
Non-Small Cell Lung Cancer, Medullary Thyroid Cancer, Colon Cancer, Any Solid Tumor
02/25
02/26
Anderson, Karen O
PIVOT-HD, NCT05358717 / 2021-003852-18: A Study to Evaluate the Safety and Efficacy of PTC518 in Participants With Huntington's Disease (HD)

Active, not recruiting
2
252
Europe, Canada, US, RoW
PTC518, Placebo
PTC Therapeutics, PTC Therapeutics, Inc.
Huntington Disease
02/25
08/25
vUHDRS, NCT05748288: Development of the Virtual Unified Huntington's Disease Rating Scale

Completed
N/A
60
US
Huntington Study Group
Huntington Disease
05/23
05/23
NCT05268029: Making HD Voices Heard

Completed
N/A
698
US
Huntington Study Group
Huntington Disease
10/23
10/23
HDClarity, NCT02855476: a Multi-site Cerebrospinal Fluid Collection Initiative to Facilitate Therapeutic Development for Huntington's Disease

Recruiting
N/A
2500
Europe, Canada, US, RoW
University College, London, CHDI Foundation, Inc.
Huntington's Disease
05/25
05/25
NCT01574053: Enroll -HD: A Prospective Registry Study in a Global Huntington's Disease Cohort

Recruiting
N/A
35000
Europe, Canada, US, RoW
CHDI Foundation, Inc.
Huntington's Disease
01/62
01/62
Latham, Nancy
NCT03716739: Improving Quality of Life of Prostate Cancer Survivors With Androgen Deficiency

Active, not recruiting
2
137
US
Testosterone Cypionate 100 MG/ML, Depo-Testosterone, Placebo, Inactive comparator
Dana-Farber Cancer Institute, National Institute on Aging (NIA)
Prostate Cancer
09/25
03/26
NCT03576001: Multimodality Intervention for Function and Metabolism in SCI

Active, not recruiting
2
84
US
Testosterone Undecanoate, hybrid exercise
Brigham and Women's Hospital, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Spaulding Rehabilitation Hospital
Spinal Cord Injuries
01/25
06/25
DKD, NCT05759468: NAD Augmentation in Diabetes Kidney Disease

Recruiting
2
140
US
Investigational Product - MIB 626, NMN, Placebo, Placebo for NMN
Brigham and Women's Hospital, Boston Medical Center
Type2diabetes, Diabetic Kidney Disease
12/25
07/26
NCT05432674: Digital Fall Prevention Study

Completed
1/2
23
US
Digital Fall Prevention
Brigham and Women's Hospital, Best Buy Health, Inc
Fall
05/23
06/23
NCT04772820: Feasibility of Remote Home Support Coaches (SOCIAL Study)

Completed
N/A
10
US
Telephone-based coaching, Remote coaching
Brigham and Women's Hospital, University of Maryland, Baltimore, National Institute on Aging (NIA)
Malnutrition, Isolation, Depression, Anxiety, Sedentary Behavior, Loneliness
06/22
11/22
eSTEPS, NCT04993781: Electronic Strategies for Tailored Exercise to Prevent FallS

Active, not recruiting
N/A
12328
US
eSTEPS CDS
Brigham and Women's Hospital, National Institute on Aging (NIA), National Institutes of Health (NIH)
Falls, Fall Injury, Exercise Self-Efficacy, Falls Self-Efficacy
05/25
08/25
Cross, Raymond K
NCT04629196: Induction Optimization With Stelara for Crohn's Disease

Terminated
4
12
US
Ustekinumab, Stelara
NYU Langone Health
Crohn Disease
01/24
01/24
PROF, NCT05938465: Study of EXE-346 Live Biotherapeutic to Reduce High Bowel Movement Frequency in Subjects with an IPAA

Recruiting
1/2
50
US
EXE-346, Placebo
Exegi Pharma, LLC, The Emmes Company, LLC
Ileal Pouch
05/26
06/26
ASSIST, NCT05316584: A Novel Remote Patient and Medication Monitoring Solution to Improve Adherence and PerSiStence With IBD Therapy

Active, not recruiting
N/A
123
US
Remote monitoring
University of Maryland, Baltimore, University of North Carolina, Chapel Hill, Vanderbilt University Medical Center, New York University, University of Cincinnati, Synchronyx, LLC
Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis
07/25
07/25
MONITOR, NCT06750731: Study of Efficacy and Adherence to Subcutaneous Vs. Intravenous Vedolizumab in Patients with Inflammatory Bowel Disease Using a Novel Remote ing Intervention

Not yet recruiting
N/A
200
US
Tappt
Mercy Medical Center, Takeda
Inflammatory Bowel Disease (IBD), Crohn's Disease, Ulcerative Colitis
09/26
09/26
HBOT-UC, NCT05987852: Hyperbaric Oxygen Therapy for Ulcerative Colitis

Recruiting
N/A
126
US
Hyperbaric Oxygen Therapy, Sham Hyperbaric Air
Northwestern University, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Ulcerative Colitis
09/27
09/27
Griffith, Bartley
BOSTON-2, NCT03656926 / 2018-003205-25: Efficacy + Safety of Liposome Cyclosporine a to Treat Bronchiolitis Obliterans Post Single Lung Transplant

Completed
3
220
Europe, US, RoW
Liposomal Cyclosporine A, L-CsA, Standard of Care, SoC
Zambon SpA, BREATH Therapeutics Inc.
Bronchiolitis Obliterans, Chronic Rejection of Lung Transplant, Lung Transplant Rejection, Lung Transplant; Complications, Lung Transplant Failure and Rejection, Chronic Lung Allograft Dysfunction
03/24
03/24
BOSTON-1, NCT03657342 / 2018-003204-39: Efficacy + Safety of Liposome Cyclosporine a to Treat Bronchiolitis Obliterans Post Single Lung Transplant

Completed
3
220
Europe, US, RoW
Liposomal Cyclosporine A, L-CsA, standard of care, SoC
Zambon SpA, BREATH Therapeutics Inc.
Bronchiolitis Obliterans, Chronic Rejection of Lung Transplant, Lung Transplant Rejection, Lung Transplant; Complications, Lung Transplant Failure and Rejection, Chronic Lung Allograft Dysfunction
04/24
04/24
Shanholtz, Carl
RECOVER, NCT04629105: Regenerative Medicine for COVID-19 and Flu-Elicited ARDS Using Lomecel-B

Active, not recruiting
1
70
US
Longeveron Mesenchymal Stem Cells (LMSCs), Placebo
Longeveron Inc.
ARDS, Human, Covid19
06/24
07/25
Gammie, James S
PACES, NCT04045665 / 2021-005022-18: Anticoagulation for New-Onset Post-Operative Atrial Fibrillation After CABG

Recruiting
3
3200
Europe, Canada, US
Antiplatelet-only strategy, Oral Anticoagulant plus background antiplatelet therapy
Icahn School of Medicine at Mount Sinai, National Heart, Lung, and Blood Institute (NHLBI), Vanderbilt University Medical Center
Atrial Fibrillation, Stroke, Bleeding
06/25
06/25
SCAD, NCT06310174: Study Examining the Effect of a Novel Cannulation Knife on User Satisfaction and Common Central Venous Catheter Insertion Complications

Recruiting
N/A
144
US
Johns Hopkins University
Central Venous Catheter Exit Site Infection
03/26
05/27
ICE-AFIB, NCT03732794: AtriCure CryoICE Lesions for Persistent and Long-standing Persistent Atrial Fibrillation Treatment

Active, not recruiting
N/A
150
US
AtriCure CryoICE & AtriClip LAA Exclusion
AtriCure, Inc.
Atrial Fibrillation (AF), Persistent Atrial Fibrillation, Longstanding Persistent Atrial Fibrillation
06/24
06/26
APOLLO, NCT03242642: Transcatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR System in Patients With Severe Symptomatic Mitral Regurgitation.

Recruiting
N/A
1056
Europe, Canada, US
Medtronic Intrepid Transcatheter Mitral Valve Replacement System (TMVR)
Medtronic Cardiovascular
Mitral Valve Regurgitation
10/26
09/36
EMPRO, NCT06027788: CTSN Embolic Protection Trial

Recruiting
N/A
842
Canada, US
CardioGard Embolic Protection Cannula, Standard Aortic Cannula
Icahn School of Medicine at Mount Sinai, National Heart, Lung, and Blood Institute (NHLBI)
Delirium, Ischemic Stroke, Acute Kidney Injury, Heart Valve Disease, Coronary Artery Disease
04/27
04/27
PRIMARY, NCT05051033: Percutaneous or Surgical Repair In Mitral Prolapse And Regurgitation for ≥60 Year-olds

Recruiting
N/A
450
Europe, Canada, US
Mitral valve repair, Mitral valve surgery, Transcatheter edge-to-edge repair, TEER
Annetine Gelijns, National Heart, Lung, and Blood Institute (NHLBI)
Mitral Valve Regurgitation
11/28
11/30
Harrison, Daniel
NCT03396822: Meningeal Inflammation on 7T MRI as a Tool for Measuring and Predicting Ocrelizumab Response in Multiple Sclerosis

Completed
N/A
24
US
Gadoteridol
University of Maryland, Baltimore, Genentech, Inc.
Multiple Sclerosis
05/23
05/23
TREAT-MS, NCT03500328: Traditional Versus Early Aggressive Therapy for Multiple Sclerosis Trial

Recruiting
N/A
900
US
Natalizumab, Alemtuzumab, Ocrelizumab, Rituximab, Cladribine, Ofatumumab, Ublituximab-xiiy, Tysabri, Lemtrada, Ocrevus, Rituxan, Mavenclad, Kesimpta, Briumvi, Glatiramer acetate, Interferons (intramuscular, subcutaneous, pegylated) Teriflunomide, Fumarates (dimethyl, diroximel, monomethyl) Fingolimod, Siponimod, Ozanimod, Ponesimod, Copaxone, Glatopa, Avonex, Betaseron, Extavia, Rebif, Plegridy, Aubagio, Tecfidera, Vumerity, Bafiertam, Gilenya, Mayzent, Zeposia, Ponvory, Tascenso
Johns Hopkins University, Patient-Centered Outcomes Research Institute, National Multiple Sclerosis Society
Multiple Sclerosis, Relapsing-Remitting
08/25
08/25
Shetty, Kirti
NCT05677971: Study to Check the Safety of Fazirsiran and Learn if Fazirsiran Can Help People With Liver Disease and Scarring (Fibrosis) Due to an Abnormal Version of Alpha-1 Antitrypsin Protein

Recruiting
3
160
Europe, Canada, US, RoW
Fazirsiran Injection, TAK-999, ARO-AAT, ADS-001, Placebo, Sodium chloride
Takeda, Takeda Development Center Americas, Inc.
Alpha1-Antitrypsin Deficiency
03/27
03/29
ARGON-2, NCT04378010 / 2019-003876-38: A Randomized, Double-blind Study to Assess the Safety and Efficacy of EDP-305 in Subjects With Liver-biopsy Proven NASH

Terminated
2b
98
Europe, Canada, US, RoW
EDP-305 1.5 mg, EDP-305, EDP-305 2 mg, Placebo
Enanta Pharmaceuticals, Inc, Enanta Pharmaceuticals, Inc.
Non-Alcoholic Steatohepatitis
10/21
11/21
NCT04505436: Study to Evaluate Efficacy, Safety and Tolerability of HM15211 in Subjects

Recruiting
2
240
US, RoW
HM15211, Placebo of HM15211
Hanmi Pharmaceutical Company Limited
NASH - Nonalcoholic Steatohepatitis
05/26
11/26
NCT03878550: Case-Control Study of the Glycotest™ HCC Panel vs AFP for the Detection of Early-stage Hepatocellular Carcinoma

Active, not recruiting
N/A
766
US, RoW
Glycotest, Inc.
Carcinoma, Hepatocellular, Cirrhosis, Liver
08/23
12/24
CHANCE, NCT04613921: Liver Transplantation in Patients With CirrHosis and Severe Acute-on-Chronic Liver Failure: iNdications and outComEs

Recruiting
N/A
3000
Europe, Canada, Japan, US, RoW
Observational Protocol
European Foundation for Study of Chronic Liver Failure
Liver Diseases, Liver Cirrhosis, Acute-On-Chronic Liver Failure, Liver Transplant; Complications
12/25
12/26
Stein, Deborah
EPR-CAT, NCT01042015: Emergency Preservation and Resuscitation (EPR) for Cardiac Arrest From Trauma

Recruiting
2
20
US
Emergency preservation and resuscitation, Standard resuscitation
University of Maryland, Baltimore, Cook County Health
Cardiac Arrest From Trauma
12/25
12/25
NCT03197675: Acupuncture in Spinal Cord Injury Subjects

Completed
N/A
69
US
Acupuncture
University of Maryland, Baltimore, United States Department of Defense
Spinal Cord Injuries
12/22
02/23
NCT05780918: A Communication Tool to Improve Communication in the ICU

Enrolling by invitation
N/A
7600
US
Best Case/Worst Case-ICU Communication Tool
University of Wisconsin, Madison, National Institute on Aging (NIA), Shock Trauma - University of Maryland Medical Center, University of California, Davis, Harborview Injury Prevention and Research Center, Lehigh Valley Health Network, Grady Memorial Hospital, Froedtert Hospital, University of Alabama at Birmingham, Rhode Island Hospital, American College of Surgeons, Coalition for National Trauma Research
Serious Injury, Communication
09/25
12/25
Hershey, Andrew
NCT04567355: Migraine Manager (R01)

Recruiting
2
160
US
Migraine Manager
Children's Hospital Medical Center, Cincinnati
Migraine, Migraine Disorders
04/25
05/25
NCT04088071: Real-world Experience of Catheter Ablation for the Treatment of Paroxysmal and Persistent Atrial Fibrillation

Recruiting
N/A
15000
US
Catheter ablation
Heart Rhythm Clinical and Research Solutions, LLC, Biosense Webster, Inc.
Paroxysmal Atrial Fibrillation, Persistent Atrial Fibrillation
12/27
12/27
Himelhoch, Seth S
NCT05011903: Integrative Alcohol and Risky Sex Feedback for College Students

Not yet recruiting
N/A
600
US
Cross-tailored Dynamic Feedback, Personalized Feedback Intervention, Dynamic Feedback on General Health Behaviors
Anne E Ray, University of North Texas Health Science Center, Klein Buendel, Inc., National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Alcohol Drinking in College, Sexual Behavior
01/27
01/27
Weir, Matthew R
NCT06474273: TACKLE-IT Trial - Treat Acute T Cell Rejection With Evidence and Confidence in Kidney Transplant Recipients

Not yet recruiting
4
540
Canada, RoW
Methylprednisolone, IV MP, Prednisone
University of Sydney, University of Manitoba
Rejection; Transplant, Kidney, Rejection; Transplant, Pancreas
12/29
12/29
PREFERRED-1, NCT05096195: PRevEnting FracturEs in REnal Disease 1

Active, not recruiting
4
60
Canada
Denosumab 60 mg/ml, Prolia, Calcium and vitamin D prophylaxis, Monitoring of post-injection calcium and phosphate
Western University, Canada, ICES, Academic Medical Organization of Southwestern Ontario, Western University, The Kidney Foundation of Canada
Kidney Diseases, Dialysis; Complications, Fragility Fracture, Chronic Kidney Disease-Mineral and Bone Disorder
12/25
12/25
ALIGN, NCT04573478: Atrasentan in Patients With IgA Nephropathy

Active, not recruiting
3
404
Europe, Canada, Japan, US, RoW
Atrasentan, CHK-01, Atrasentan Hydrochloride, ABT-627, Placebo
Chinook Therapeutics, Inc.
IgA Nephropathy, Immunoglobulin A Nephropathy
12/26
12/26
ACHIEVE, NCT03020303 / 2020-001882-36: Aldosterone BloCkade for Health Improvement EValuation in End-stage Renal Disease

Recruiting
3
2750
Europe, Canada, RoW
Spironolactone 25Mg Tablet, Placebo Oral Tablet
Population Health Research Institute, Canadian Institutes of Health Research (CIHR)
Endstage Renal Disease
07/25
04/26
NCT04658017: GARNETâ„¢ Filter (GARNET Device) IDE Used in Chronic Hemodialysis Patients With a Bloodstream Infection

Recruiting
N/A
15
US
GARNET device
Boa Biomedical, Inc., Avania
Bloodstream Infection
10/21
12/21
PHOSPHATE, NCT03573089: Pragmatic Randomised Trial of High Or Standard PHosphAte Targets in End-stage Kidney Disease

Recruiting
N/A
3600
Europe, Canada, RoW
Liberal phosphate target, Intensive phosphate target
The University of Queensland, National Health and Medical Research Council, Australia, Applied Health Research Centre, Cambridge University Hospitals NHS Foundation Trust, University of Otago
Kidney Failure, Chronic, Hyperphosphatemia
12/27
12/28
APOLLO, NCT03615235: APOL1 Long-term Kidney Transplantation Outcomes Network

Recruiting
N/A
5000
US
Wake Forest University Health Sciences, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institute on Minority Health and Health Disparities (NIMHD), National Institute of Allergy and Infectious Diseases (NIAID)
Kidney Diseases, Kidney Failure, Kidney Disease, Chronic
09/24
09/24
COPE-AKI, NCT05805709: A Patient-centered Trial of a Process-of-care Intervention in Hospitalized AKI Patients: the Trial

Recruiting
N/A
2145
US
Study Physician/Advance Practice Provider, Nurse Navigator, Pharmacist, Patient Education
University of Pittsburgh, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Acute Kidney Injury
06/26
03/27
Coffey, Christopher
NCT01141023 / 2010-019894-13: Study to Identify Clinical, Imaging and Biologic Markers of Parkinson Disease Progression

Completed
2
952
Europe, US, RoW
DaTscan, Ioflupane
Ken Marek, MD, Institute for Neurodegenerative Disorders
Parkinson Disease
06/20
06/20
Kreisel, Daniel
ALL IN LUNG, NCT06033196: Tocilizumab in Lung Transplantation

Recruiting
2
350
Canada, US
Tocilizumab, ACTEMRA, Placebo for Tocilizumab
National Institute of Allergy and Infectious Diseases (NIAID)
Lung Transplant
01/29
01/29
INTERLUNG, NCT02812290: Diagnostic and Therapeutic Applications of Microarrays in Lung Transplantation

Recruiting
N/A
700
Europe, Canada, US, RoW
Lung transplant biopsy bites.
University of Alberta
Lung Transplant Rejection
11/25
06/26
Levitsky, Josh
NCT01846663: Efficacy, Safety, And Pharmacokinetics Of Rifaximin In Subjects With Severe Hepatic Impairment And Hepatic Encephalopathy

Terminated
4
6
US
Placebo, Rifaximin, XIFAXAN® Tablets
Bausch Health Americas, Inc.
Hepatic Encephalopathy
02/16
02/16
NCT05325073: Erythropoietin Therapy to Induce Regulatory T Cells in Liver Transplant Recipients

Active, not recruiting
4
9
US
Erythropoietin
Northwestern University
Liver Transplant Rejection
05/23
09/24
NCT05569759: A Study of Zetomipzomib (KZR-616) in Patients With Autoimmune Hepatitis (PORTOLA)

Active, not recruiting
2
24
US
zetomipzomib, KZR-616, placebo, sterile water for injection, zetomipzomib in open-label extension
Kezar Life Sciences, Inc.
Autoimmune Hepatitis
02/25
08/25
ELIMINATE, NCT06280950: Expanding Liver Transplant Immunosuppression Minimization Via Everolimus

Recruiting
2
340
US
Everolimus, Zortress, Tacrolimus (continued reduction), FK-506, FR-900506, Prograf, Prograft, Tacrolimus (maintain 50% reduction)
National Institute of Allergy and Infectious Diseases (NIAID)
Liver Transplant
06/27
06/29
"Mini-Liver", NCT01644903: Proteogenomic Monitoring and Assessment of Liver Transplant Recipients

Recruiting
N/A
1000
US
Northwestern University, The Scripps Research Institute
Liver Transplant, Hepatitis C, Chronic Kidney Disease, Acute Rejection
12/24
12/25
INTERLIVER, NCT03193151: Diagnostic and Therapeutic Applications of Microarrays in Liver Transplantation

Recruiting
N/A
300
Europe, Canada, US, RoW
liver biopsy
University of Alberta
Liver Dysfunction
12/25
12/26
Bromberg, Jonathan
NCT04803006: A Study of TCD601 in the Induction of Tolerance in Renal Transplantation (PANORAMA)

Recruiting
2
18
US
TCD601
ITB-Med LLC
Kidney Transplantation
07/27
07/30
NCT04239703: Trifecta-Kidney cfDNA-MMDx Study

Recruiting
N/A
300
Europe, Canada, US, RoW
MMDx, Prospera, transplant patient blood sample, HLA antibody
University of Alberta, Natera, Inc., One Lambda
Kidney Transplant Rejection
12/25
12/26
APOLLO, NCT03615235: APOL1 Long-term Kidney Transplantation Outcomes Network

Recruiting
N/A
5000
US
Wake Forest University Health Sciences, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institute on Minority Health and Health Disparities (NIMHD), National Institute of Allergy and Infectious Diseases (NIAID)
Kidney Diseases, Kidney Failure, Kidney Disease, Chronic
09/24
09/24
KOAR, NCT03326076: Evaluation of Patient Outcomes From the Kidney Allograft Outcomes AlloSure Registry

Active, not recruiting
N/A
4000
US
Donor-derived cell-free DNA (AlloSure®), Standard care, Peripheral blood gene expression profiling (AlloMap Kidney), Analytic platform (IBox)
CareDx
Kidney Transplant Rejection
06/25
12/25
ProActive, NCT04091984: The PROspera Kidney Transplant ACTIVE Rejection Assessment Registry

Active, not recruiting
N/A
5000
US
Prospera
Natera, Inc., University of Maryland
Kidney Transplant Rejection
10/26
10/27
 

Download Options