| FUTIER, Emmanuel |
| Not yet recruiting | N/A | 5000 | Europe | questionnaire filling | Centre Hospitalier Universitaire de NÄ«mes | Critical Illness, Covid19, Stress Disorders, Post-Traumatic | 09/22 | 09/22 | | |
GOAL, NCT03461900: Guided Fluid-balance Optimization With Mini-fluid chALlenge During Septic Shock |
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| Completed | N/A | 535 | Europe | Minifluid challenge, Usual practice | University Hospital, Brest | Septic Shock | 08/23 | 01/24 | | |
MAKI, NCT05247502: Impact of the Characteristics of Acute Renal Failure in Intensive Care on the Long-term Renal Prognosis: Prospective Multicenter Cohort Study |
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| Recruiting | N/A | 860 | Europe | Data observation | University Hospital, Clermont-Ferrand | Acute Kidney Injury, Transient Acute Renal Failure, Persistent Acute Renal Failure | 11/28 | 11/28 | | |
PEFLA, NCT06011187: Assisted Fluid Management (AFM) System and Postoperative Outcome After High-risk Abdominal Surgery |
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| Recruiting | N/A | 2000 | Europe, Canada, US | Routine care, AFM | Assistance Publique - Hôpitaux de Paris | Decision Support System, Outcome | 05/26 | 12/26 | | |
| Schmidt, Jeannot |
SAFE-SSPE, NCT04263038: Clinical Surveillance vs. Anticoagulation for Low-risk Patients With Isolated Subsegmental Pulmonary Embolism |
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| Recruiting | 4 | 276 | Europe, Canada | Rivaroxaban, Placebo | Drahomir Aujesky, University of Bern, Schweizerischer Nationalfonds, Leiden University Medical Center, The Ottawa Hospital, Bayer | Pulmonary Embolism, Embolism, Embolism and Thrombosis, Lung Diseases, Cardiovascular Diseases, Respiratory Tract Diseases, Venous Thromboembolism, Anticoagulant-induced Bleeding, Bleeding | 05/26 | 05/26 | | |
InSaKa, NCT04012138: Insulin Dextrose Infusion vs Nebulized Salbutamol vs Combination of Salbutamol and Insulin Dextrose in Acute Hyperkalemia |
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| Recruiting | 4 | 525 | Europe | Salbutamol, Salbutamol and Hyperkaliemia, Insulin Aspart, Insulin and Hyperkaliemia | Nantes University Hospital | Hyperkalemia | 12/25 | 06/26 | | |
DEBRIEF-VTE, NCT04141254: Impact of Early Debriefing and Enhanced Educative Components on Direct Oral Anticoagulant Adherence After Venous Thromboembolism. |
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| Recruiting | 3 | 150 | Europe | Debriefing and educative components, Without debriefing and educative components | University Hospital, Brest, Bristol-Myers Squibb | Venous Thromboembolism | 12/21 | 12/21 | | |
RENOVE, NCT03285438: REduced Dose Versus Full-dose of Direct Oral Anticoagulant After uNprOvoked Venous thromboEmbolism. |
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| Completed | 3 | 2774 | Europe | Reduced dose of DOAC, Full dose of DOAC | University Hospital, Brest, University Hospital of Saint-Etienne | Venous Thromboembolism | 11/23 | 11/23 | | |
| Completed | 3 | 1766 | Europe, Canada | Apixaban 5 MG, Apixaban 2.5 MG | Assistance Publique - Hôpitaux de Paris, Bristol-Myers Squibb | Cancer-associated Thrombosis | 09/24 | 10/24 | | |
| Recruiting | 3 | 650 | Europe, Canada, RoW | Alteplase, Placebo | Assistance Publique - Hôpitaux de Paris, Johannes Gutenberg University Mainz, Life Sciences Research Partners (D Collen Research Foundation), Canadian Institutes of Health Research (CIHR), Instituto de Salud Carlos III, International Network of VENous Thromboembolism Clinical Research Networks, Boehringer Ingelheim | Pulmonary Embolism | 09/25 | 08/27 | | |
| Recruiting | 3 | 328 | Europe, Canada, US | TAK-330, SOC 4F-PCC | Takeda, Takeda Development Center Americas, Inc. | Coagulation Disorder | 04/28 | 04/28 | | |
BAT-VTE, NCT05627375: Best Antithrombotic Therapy in Patients With Acute Venous ThromboEmbolism While Taking Antiplatelets |
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| Recruiting | 3 | 1400 | Europe | Full-dose anticoagulant therapy (AC), Antiplatelet therapy (AP) | Centre Hospitalier Universitaire de Saint Etienne, Ministry of Health, France | Venous Thromboembolic Disease | 12/27 | 12/28 | | |
| Recruiting | N/A | 2640 | Europe | Case group, Control group | University Hospital, Brest | Venous Thromboembolic Disease | 10/26 | 10/26 | | |
| Completed | N/A | 1025 | Europe | | University Hospital, Clermont-Ferrand | Traumatic Brain Injury, Intracranial Injury | 08/24 | 08/24 | | |
| Completed | N/A | 409 | Europe | | University Hospital, Brest | Pulmonary Embolism, Proximal Deep Vein Thrombosis | 03/23 | 03/23 | | |
| Completed | N/A | 80 | Europe | Quantra analyzer | University Hospital, Clermont-Ferrand, Hôpital Edouard Herriot, University Hospital of Saint-Etienne, University Hospital, Grenoble, University Hospital, Tours, Pitié-Salpêtrière Hospital | Anticoagulants and Bleeding Disorders | 01/24 | 01/24 | | |
GUEST, NCT05885529: Glial Fibrillary Acidic Protein (GFAP) and Ubiquitin Carboxy-terminal Hydrolase L1 (UCH-L1) to Exclude Lesions Linked to Significant Traumatic Brain Injuries |
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| Not yet recruiting | N/A | 1500 | Europe, RoW | UCH-L1 GFAP | Centre Hospitalier Princesse Grace, BioMérieux, Assistance Publique - Hôpitaux de Paris, University Hospital, Clermont-Ferrand, Hospices Civils de Lyon, Poitiers University Hospital, University Hospital, Angers, Centre Hospitalier Universitaire de Nīmes, Centre Hospitalier Universitaire de Nice, Nantes University Hospital, University Hospital, Montpellier, Centre Hospitalier Universitaire Dijon, University Hospital, Grenoble, Fondation Hôpital Saint-Joseph, CHU de Tours | Traumatic Brain Injury | 10/24 | 03/25 | | |
ETHER, NCT06731244: Shared Decision-making Process for Unprovoked VEnous THromboEmbolism Management. ( ) |
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| Not yet recruiting | N/A | 2400 | Europe | Usual Care Group, shared decision-making process | University Hospital, Brest, European Commission | Venous Thromboembolism | 10/28 | 10/28 | | |
CATforCAT, NCT06386107: Thrombin Generation Parameters and Bleeding in Patients Treated With Anticoagulants for Cancer Associated Thrombosis |
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| Not yet recruiting | N/A | 212 | Europe | Thrombin Generation Assay (TGA) | Centre Hospitalier Universitaire de Saint Etienne, Diagnostica Stago, LEO Pharma, Ligue contre le cancer, France | Cancer, Pulmonary Embolism, Thrombosis | 02/26 | 02/27 | | |
HYDRA, NCT04657120: Safety and Efficiency of the YEARS Algorithm Versus Computed Tomography Pulmonary Angiography Alone for Suspected Pulmonary Embolism in Patients With Malignancy |
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| Recruiting | N/A | 1566 | Europe | YEARS algorithm, CTPA | University Hospital, Brest, Leiden University Medical Center, Insel Gruppe AG, University Hospital Bern, University Hospital, Antwerp | Pulmonary Embolism, Embolism, Embolism and Thrombosis, Vascular Diseases, Cardiovascular Diseases, Lung Diseases, Respiratory Tract Diseases, Cancer, Diagnosis | 05/24 | 05/24 | | |
SEEK, NCT02401607: Study - Study on Emergency Health Care Workers' Job Strain Evaluated by Karasek Questionnaire |
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| Recruiting | N/A | 100 | Europe | Karasek questionnaire and Saliva prelevement | University Hospital, Clermont-Ferrand, Association des Médecins des Urgences de Clermont-Ferrand, Université d'Auvergne | Health Care Workers | 05/25 | 05/25 | | |
DISCUSS, NCT06071078: Impact of a Protocol for Announcing Decision of Withholding and Withdrawing Life-sustaining Treatments on the Stress of the Relatives in the Emergency Departments |
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| Not yet recruiting | N/A | 532 | Europe | Training of professionals according to the DISCUSS announcement protocol | Hospices Civils de Lyon | End of Life | 10/25 | 10/25 | | |
| Recruiting | N/A | 1276 | Europe, Canada | Limited cancer screening, Limited cancer screening + FDG PET/CT | University Hospital, Brest, Ministry of Health, France, Canadian Institutes of Health Research (CIHR), Ottawa Hospital Research Institute | Embolism and Thrombosis | 09/26 | 09/30 | | |
| PAILLARD, Catherine |
| Recruiting | 3 | 800 | Europe, RoW | Vincristine, L01CA02, Carboplatin, LO1XA02, Etoposide, L01CB01, Vindesine, L01CA03, Dacarbazine, L01AX04, Ifosfamide, Doxorubicin, L01DB01, Busulfan, L01AB01, Melphalan, L01AA03, Thiotepa, L01AC01, Radiotherapy, Dinutuximab Beta, L01XC16, Cisplatin, L01XA01, Temozolomide 100 MG, Irinotecan, Cyclophosphamid | Gustave Roussy, Cancer Campus, Grand Paris, PHRC, Solving Kids' Cancer Europe, Neuroblastoma UK, , BSPHO, Instituto de Investigación Sanitaria La Fe, Deutsche Krebshilfe | High-Risk Neuroblastoma, Patient With Insufficient Response Chemoimmunotherapy | 11/26 | 11/32 | | |
| Recruiting | 3 | 6430 | Europe, RoW | Omitted Doxorubicin, Omitted Vincristine+Dexamethasone pulses, Inotuzumab Ozogamicin+Standard Maintenance Therapy, Besponsa+Maintenance Therapy, Imatinib, 6-tioguanine+Standard Maintenance Therapy, Blinatumomab, Blincyto | Mats Heyman, The Swedish Research Council, The Swedish Childhood Cancer Foundation, Pfizer, Servier, NordForsk, Aamu Pediatric Cancer Foundation, German Society for Pediatric Oncology and Hematology GPOH gGmbH, Clinical Trial Center North (CTC North GmbH & Co. KG), Belgium Health Care Knowledge Centre, Karolinska Institutet, Cancer Research UK, Fundação Rui Osório de Castro, Acreditar - Associação de Pais e Amigos das Crianças com Cancro, Grupo Português De Leucemias Pediátricas, Amgen, Nova Laboratories Limited, Danish Child Cancer Foundation, Danish Cancer Society, The Novo Nordic Foundation, Assistance Publique - Hôpitaux de Paris, Direction Générale de l'Offre de Soins | Leukemia, Acute Lymphoblastic | 06/27 | 06/32 | | |
| Recruiting | 2/3 | 1800 | Europe, Canada, RoW | VP16, Etoposide, TBI, Thiotepa, Thio, Treosulfan, Treo, Fludarabine, Flu, Busulfan, Bu, ATG Thymoglobulin, ATG Thymo, Cyclophosphamide, Cy, Grafalon, Anti-human T-lymphocyte immunoglobulin | St. Anna Kinderkrebsforschung, ALL SCTped Forum, European Society for Blood and Marrow Transplantation, ALL-BFM Study Group, Assistance Publique - Hôpitaux de Paris, Dutch Childhood Oncology Group, Swiss Pediatric Oncology Group, Australian & New Zealand Children's Haematology/Oncology Group | Acute Lymphoblastic Leukaemia | 06/25 | 04/30 | | |
| Recruiting | 2/3 | 536 | Europe, RoW | 16 weeks of VEC + CDDP, Vincristine, Etoposide, Cyclophosphamide, Cisplatin, VEC + HD-MTX, Methotrexate, Chemotherapy + Valproate, Carboplatin, Valproate, Conformal radiotherapy, VEC, Chemotherapy, conformal radiotherapy +/- boost | Centre Leon Berard | Childhood Ependymoma | 06/28 | 08/31 | | |
CAPTiRALL, NCT05310591 / 2021-003035-28: Combination of an Anti-PD1 Antibody With Tisagenlecleucel Reinfusion in Children, Adolescents and Young Adults With Acute Lymphoblastic Leukemia After Loss of Persistence |
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| Recruiting | 1/2 | 26 | Europe | Decreasing starting times for beginning nivolumab (Time to Event Continual Reassessment Method (TITE-CRM) ), Nivolumab starting at day -1 | Assistance Publique - Hôpitaux de Paris, DGOS | B Acute Lymphoblastic Leukemia, Acute Lymphoblastic Leukemia, in Relapse | 03/27 | 03/27 | | |
CURALASE01, NCT04596410: Photobiomodulation Protocols in the Analgesia of Chemotherapy-induced Oral Mucositis in Children |
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| Recruiting | N/A | 406 | Europe | LLLT applied every other day, LLLT applied daily | University Hospital, Toulouse | Mucositis Oral | 01/24 | 02/24 | | |
DREPAGREFFE2, NCT05053932: Long-term Comparative Cerebrovascular Outcome After Transplantation vs Standard Care in Sickle Cell Anemia |
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| Recruiting | N/A | 67 | Europe | blood collection | Centre Hospitalier Intercommunal Creteil, Centre National de la Recherche Scientifique, France, Etablissement Français du Sang | Sickle Cell Disease, Cerebral Ischemia, Stenosis | 06/24 | 06/25 | | |
| Recruiting | N/A | 300 | Europe, RoW | Collection of blood sample or saliva, Collection of a tumor sample taken before the participation of the patient in study, Collection of blood sample if tumor sample is not available | University Hospital, Angers | Predisposition, Genetic, Cancer Childhood, Development Delay | 02/25 | 08/25 | | |
| Active, not recruiting | N/A | 2093 | Europe, RoW | Hydroxycarbamide, Siklos, Hydroxyurea | Theravia, International Clinical Trials Association | Sickle Cell Disease | 08/25 | 08/25 | | |
MICCHADO, NCT03496402: Biological Characterisation of High Risk CHildhood Cancer in Children, Adolescents and Young Adults |
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| Active, not recruiting | N/A | 600 | Europe | Sampling on blood, bone marrow and cerebrospinal fluid | Institut Curie | Neuroblastoma, Rhabdomyosarcoma, Ewing Sarcoma Family of Tumors, Osteosarcoma, Leukemia, Central Nervous System Tumor | 04/27 | 08/27 | | |
ALARM3, NCT05772559: Acute Myeloid Leukemia At Initial Diagnosis and/or Relapse in Children, Teenagers and Young Adults: Molecular Profiling, Multidrug Testing and MSC Interaction Studies |
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| Recruiting | N/A | 500 | Europe | Collection of blood sample of bone marrow (cohort 1), Collection of blood sample of bone marrow (cohort 2 and 3) | Assistance Publique - Hôpitaux de Paris | Acute Myeloid Leukemia, Genetic Predisposition to Disease | 05/33 | 05/33 | | |
GATA-2, NCT05983991: Study for Characterisation of Predictive Parameters of Clonal Evolution in Subjects With GATA2 Germline Mutation |
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| Recruiting | N/A | 150 | Europe | Biological samples (blood and bone marrow samples). | Institut Claudius Regaud | GATA2 Gene Mutation | 10/33 | 10/33 | | |
OnKO-TnT-1-0, NCT05617131: Cell Phone Application to Help Adolescents and Young Adults in Their Therapeutic and Educational Journey |
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| Recruiting | N/A | 60 | Europe | | University Hospital, Strasbourg, France | Cancer | 12/23 | 12/23 | | |
BKV-Allograf, NCT05618275: Role of Neutralizing Antibodies in the Prediction and Treatment of BK Virus Infection in Hematopoietic Stem Cell Allograft Patients at the Pediatric Oncology-hematology Department of the HUS |
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| Recruiting | N/A | 100 | Europe | | University Hospital, Strasbourg, France | BK Virus Infection | 12/22 | 12/22 | | |
| LEBRETON, Aurélien |
| Completed | N/A | 80 | Europe | Quantra analyzer | University Hospital, Clermont-Ferrand, Hôpital Edouard Herriot, University Hospital of Saint-Etienne, University Hospital, Grenoble, University Hospital, Tours, Pitié-Salpêtrière Hospital | Anticoagulants and Bleeding Disorders | 01/24 | 01/24 | | |
| Active, not recruiting | N/A | 70 | Europe | Blood test | University Hospital, Clermont-Ferrand | Hereditary Dysfibrinogenemia | 05/24 | 12/24 | | |
NCT03625726: Rôle of the Soluble Endothelial Protein C Receptor in Cirrhosis-associated Hypercoagulability State (EXERCISE) |
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| Recruiting | N/A | 300 | Europe | Thrombin generation assay (in vitro) | University Hospital, Clermont-Ferrand | Cirrhosis | 08/24 | 08/24 | | |
EVIGE, NCT05422157: Evaluation of the Inter-center Variability of the Measurement of Thrombin Generation by the ST Genesia System |
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| Completed | N/A | 71 | Europe | | University Hospital, Clermont-Ferrand, Diagnostica Stago | Patients Without a Medical History of Thrombosis or Hemorrhage, Hemophilic Patient, Patient With FV Leiden Mutation, Patient With Cirrhosis, Patient on Anticoagulant | 11/23 | 11/23 | | |
TROPHE, NCT06575309: THROmbinography in Pregnant Woman and in Vitro Action of Low Molecular Weight HEparin |
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| Recruiting | N/A | 50 | Europe | Blood test | University Hospital, Clermont-Ferrand | Pregnant Women, Venous Thromboembolic Disease | 11/25 | 05/27 | | |
WILL MANAGE, NCT06651255: Algorithm-based Management to Reduce the Recurrence of Gastrointestinal Bleeding and Severe Epistaxis in Von Willebrand Disease |
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| Not yet recruiting | N/A | 66 | Europe | Optimized management, Standard of care management | University Hospital, Lille | Von Willebrand Disease (VWD) | 01/34 | 12/34 | | |
CATforCAT, NCT06386107: Thrombin Generation Parameters and Bleeding in Patients Treated With Anticoagulants for Cancer Associated Thrombosis |
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| Not yet recruiting | N/A | 212 | Europe | Thrombin Generation Assay (TGA) | Centre Hospitalier Universitaire de Saint Etienne, Diagnostica Stago, LEO Pharma, Ligue contre le cancer, France | Cancer, Pulmonary Embolism, Thrombosis | 02/26 | 02/27 | | |
| Recruiting | N/A | 150 | Europe | blood sample | Hospices Civils de Lyon | Antiphospholipid Syndrome | 03/27 | 03/27 | | |
| Not yet recruiting | N/A | 350 | Europe | questionnaires, RedCap web platform | University Hospital, Clermont-Ferrand | Chronic Pain, Hemophilia | 01/23 | 06/23 | | |
| Moustafa, Farès |
| Recruiting | N/A | 10 | Europe | emergency | University Hospital, Clermont-Ferrand | Antithrombotic Agents | 01/24 | 02/24 | | |
| Completed | N/A | 80 | Europe | Quantra analyzer | University Hospital, Clermont-Ferrand, Hôpital Edouard Herriot, University Hospital of Saint-Etienne, University Hospital, Grenoble, University Hospital, Tours, Pitié-Salpêtrière Hospital | Anticoagulants and Bleeding Disorders | 01/24 | 01/24 | | |
NCT02832245: Computerized Registry of Patients With Venous Thromboembolism (RIETE) |
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| Recruiting | N/A | 120000 | Europe, Japan, US, RoW | | Manuel Monreal | Venous Thromboembolism | 12/26 | 12/27 | | |
| Delage, Noémie |
E-PENEPA, NCT04431778: Evaluation of the Efficacy and Tolerance of Low Doses of Ethosuximide in the Treatment of Peripheral Neuropathic Pain |
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| Recruiting | 2 | 64 | Europe | Ethosuximide, Placebo | University Hospital, Clermont-Ferrand | Peripheral Neuropathic Pain | 11/23 | 12/23 | | |
FIBOBS, NCT04775368: Fibromyalgia Syndrome in France: The Role of Assessment and Management of Sleep Disorders |
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| Completed | N/A | 601 | Europe | Administering diagnosis orientation questionnaires for the screening of possible sleep disorders | Centre Hospitalier Emile Roux, Walisco, University Hospital, Clermont-Ferrand | Fibromyalgia | 03/23 | 03/23 | | |
CAPSICAURA, NCT05817591: Response Profiles to High-concentration Capsaicin Desensitization in Patients With Peripheral Neuropathic Pain With or Without Allodynia: a Regional Multicenter Prospective Cohort |
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| Recruiting | N/A | 400 | Europe | Questionnaires | Centre Hospitalier Annecy Genevois | Peripheral Neuropathic Pain | 06/26 | 06/26 | | |
| Recruiting | N/A | 5000 | Europe | eDOL | University Hospital, Clermont-Ferrand, Institut ANALGESIA | Chronic Pain | 09/26 | 09/26 | | |
| BRUGNON, Florence |
| Completed | N/A | 101 | Europe | | University Hospital, Clermont-Ferrand | Healthy, Cancer, Infertility, Male, Cryopreservation | 10/20 | 03/23 | | |
FERTICOVID, NCT04487639: Presence of SARS-CoV-2 (COVID-19) in Semen: Impact on Fertility Preservation in Male Oncological Patients ? |
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| Completed | N/A | 129 | Europe | SARS-CoV-2 research in nasopharyngeal swab, sperm and serologics | University Hospital, Clermont-Ferrand, Agence de La Biomédecine | Sperm Preservation in Oncological Patients, Fertility, Cryopreservation | 07/21 | 12/23 | | |
FERTIOVO, NCT06724471: Preservation of Women's Fertility: Evaluation of Innovative Methods for Ovarian Tissue Cryopreservation |
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| Recruiting | N/A | 30 | Europe | Human ovarian tissue cryopreservation using thermosoldered or screwed cryovials | University Hospital, Clermont-Ferrand, CryoBioSystem, IMoST UMR 1240 Inserm-Université Clermont Auvergne | Infertility, Female | 06/25 | 12/25 | | |
| Not yet recruiting | N/A | 60 | Europe | AMH test, pelvic ultrasound | University Hospital, Clermont-Ferrand | HIV, Infertility | 06/22 | 11/22 | | |
| Completed | N/A | 150 | Europe | Hypnotic relaxation induced by virtual reality (device), local anesthesia | University Hospital, Clermont-Ferrand | Oocyte Retrieval, Pain, Fertilization in Vitro | 03/24 | 07/24 | | |
Devit, NCT04758819: Efficiency of Comprehensive Chromosomal Testing of Trophectoderm Biopsies of Blastocysts in In Vitro Fertilization |
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| Recruiting | N/A | 700 | Europe | Comprehensive chromosomal Testing of Trophectoderm biopsies of Blastocysts (CTTEB) | Assistance Publique - Hôpitaux de Paris | Infertility | 01/26 | 01/26 | | |
NCT04715828: Impact of Ionizing Treatment on the Nuclear Structure of Human Spermatozoa. |
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| Recruiting | N/A | 200 | Europe | Cryopreserved semen, Acute and low irradiation, Long and low irradiation, Long and medium irradiation | University Hospital, Clermont-Ferrand, Agence de La Biomédecine | Sperm Preservation, Irradiated Semen | 01/22 | 01/22 | | |
| Godet, Thomas |
| Completed | N/A | 756 | Europe | Extubation in operative room, Extubation in post anesthesia care unit | University Hospital, Clermont-Ferrand, University Hospital, Montpellier | Anesthesia, Intubation, Surgery, Extubation, Respiratory Failure, Complication,Postoperative | 01/23 | 02/23 | | |
| Recruiting | N/A | 20 | Europe | | University Hospital, Clermont-Ferrand | SARS-CoV-2 Infection, Intensive Care Unit Patient, Neurological Abnormality, Delirium, Encephalopathy | 06/21 | 08/21 | | |
PEEP-Réa, NCT04503876: Effects of End-expiratory Positive Pressure Optimization in Intubated Patients With Healthy Lung or Acute Respiratory Distress Syndrome |
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| Recruiting | N/A | 45 | Europe | Increasing PEEP setting, Decreasing PEEP setting | University Hospital, Clermont-Ferrand | ICU Patients, Healthy Lung, Positive End-Expiratory Pressure, ARDS, Alveolar Recruitment Maneuver | 09/21 | 10/21 | | |
MacSize, NCT05059067: Macintosh Blade Size During Laryngoscopy for Endotracheal Intubation. A Prospective Observational Study. |
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| Recruiting | N/A | 1500 | Europe | Direct laryngoscopy for endotracheal intubation | University Hospital, Clermont-Ferrand | Endotracheal Intubation | 12/21 | 01/22 | | |
CHARM-Bloc, NCT05365113: Comparison of Hemodynamic Effects of Two Modalities of Alveolar Recruitment Maneuvers in Major Abdominal Surgery Patients |
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| Completed | N/A | 20 | Europe | alveolar recruitment maneuver | University Hospital, Clermont-Ferrand | Cardiac Output, Decreased Cardiac Output, Hemodynamic Monitoring, Blood Pressure, Stroke Volume, Major Abdominal Surgery, Mechanical Ventilation, Hemodynamic Optimization | 05/22 | 05/22 | | |
FiO2RI, NCT05085119: Validation of the Relationship Between Oxygenation Parameters and ORI™, in Mechanically Ventilated ICU Patients |
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| Completed | N/A | 30 | Europe | Stepwise modifications of FiO2 | University Hospital, Clermont-Ferrand | Intubation, Mechanical Ventilation, Intensive Care Unit | 08/22 | 08/22 | | |
ECRO, NCT03426943: Endotoxins and Cytokines Removal During Continuous Hemofiltration With oXiris™ |
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| Completed | N/A | 39 | Europe | Arterial blood sampling, Ultrafiltrate sampling, CVVH using oXiris™ filter, CVVH using PrismafleX HF1400 filter | Hospices Civils de Lyon, Baxter Healthcare Corporation | Septic Shock, Peritonitis | 06/22 | 06/22 | | |
| Completed | N/A | 30 | Europe | Trigger setting of pressure support ventilation | University Hospital, Clermont-Ferrand | ICU Patients, Intubation, Spontaneously Breathing, Pulmonary Function, Tracheotomy | 01/23 | 01/23 | | |
InLarge, NCT05056961: Effects of Large Tidal Volumes Despite Minimal Inspiratory Support in Spontaneously Ventilated Intubated Resuscitation Patients. Pathophysiological Exploratory Study. |
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| Recruiting | N/A | 30 | Europe | Multiparametric mesurements, Oesophageal pressure, Gastric pressure, P0,1, Tomography electro-impedancemetry | University Hospital, Clermont-Ferrand | Invasive Mechanical Ventilation, Ventilator-Induced Lung Injury, Patient-Self Inflicted Lung Injury, Encephalopathy, Intensive Care Unit, Tidal Volume | 06/23 | 06/23 | | |
CoC, NCT06194058: Rapid Sequence Intubation and Hemodynamic Disorders in the Operating Room: a Prospective Multicenter Observational Study |
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| Recruiting | N/A | 1150 | Europe | rapid sequence anesthetic induction | Nantes University Hospital, Société Française d'Anesthésie et de Réanimation | Rapid Sequence Intubation | 11/24 | 05/25 | | |
| Completed | N/A | 227 | Europe | Pleural drainage procedure with Seldinger procedure, Pleural drainage procedure with surgical-like technique | University Hospital, Clermont-Ferrand | Pleural Effusion, Pneumothorax, Hemothorax | 04/23 | 06/23 | | |
| Not yet recruiting | N/A | 3000 | NA | Direct laryngoscopy using Macintosh blade | University Hospital, Clermont-Ferrand, Société Française d'Anesthésie-Réanimation (SFAR) | Intubation Complication, Intubation; Difficult or Failed, Endotracheal Intubation | 06/24 | 07/24 | | |
| Recruiting | N/A | 20 | Europe | Alveolar Recruitment Maneuver (ARM) | University Hospital, Clermont-Ferrand | Cardiac Output, Hemodynamic Optimization, Monitoring Blood Pressure, Stroke Volume, Mechanical Ventilation, Acute Respiratory Distress Syndrome | 03/24 | 03/24 | | |
SIMBAVU 2, NCT06481618: Impact of Stress on Management of BAVU Ventilation (Self-filling Bag With One-way Valve) by Healthcare Professionals. |
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| Recruiting | N/A | 90 | Europe | | University Hospital, Clermont-Ferrand | Any Healthcare Professional, Agreement to Participate, Who May be Required to Perform Manual Ventilation | 10/24 | 10/24 | | |
| Laclautre, Lise |
| Recruiting | 4 | 300 | Europe | Furosemide, Hydrochlorothiazide | University Hospital, Clermont-Ferrand, University Hospital, Grenoble, Hospices Civils de Lyon, Hôpital de la Croix-Rousse, CH Puy en Velay, CH Moulins-Yzeure, CH Riom, Infirmerie Protestante de Lyon, CH Issoire, CH Annecy Genevois | Heart Failure, Acute Heart Failure, Chronic Heart Failure | 12/21 | 12/21 | | |
| Not yet recruiting | 4 | 120 | Europe | Capsaicin 179 Mg Cutaneous Patch, QUTENZA, Capsaicine low dose 0.04 %, control treatment | University Hospital, Clermont-Ferrand, Grünenthal GmbH | Osteoarthritis Hand, Neuropathic Pain | 01/28 | 01/28 | | |
| Recruiting | 4 | 90 | Europe | Ketamine + Magnesium sulfate (drug combination) | University Hospital, Clermont-Ferrand, Institut National de la Santé Et de la Recherche Médicale, France | Refractory Chronic Cluster Headache | 09/24 | 12/24 | | |
| Recruiting | 4 | 520 | Europe | Balloon for cervical ripening (Teleflex French Dufour catheter CH20 reference 174000), Oxytocin, Misoprostol Oral Tablet | University Hospital, Clermont-Ferrand | Induction of Labor, Cervical Ripening, Premature Rupture of Fetal Membranes, Nulliparous | 02/25 | 02/26 | | |
| Not yet recruiting | 4 | 80 | Europe | ALLERSPRAY-G (device A), PCNS (device B) | University Hospital, Clermont-Ferrand, Vitrobio | Allergic Rhinitis | 03/26 | 03/26 | | |
| Recruiting | 4 | 55 | Europe | therapeutic program including intermittent drug intake and multimodal rehabilitation program | University Hospital, Clermont-Ferrand, Plateforme d'Investigation Clinique, INSERM CIC1405, CHU de Clermont-Ferrand, France, Fondation Apicil, Médecine Physique et Réadaptation, CHU de Clermont-Ferrand, France, Médecine du Sport et Explorations Fonctionnelles, CHU de Clermont-Ferrand, France, Rhumatologie, CHU de Clermont-Ferrand, France, Direction de la Recherche Clinique et des Innovations, CHU de Clermont-Ferrand, France, SARL BOUCHARENC, Saint-Chély d'Apcher, France, Inserm U1107 " Neuro-Dol ", Clermont-Ferrand, France, Université Clermont-Auvergne, France | Osteoarthritis, Knee, Osteoarthritis, Hip, Chronic Pain | 07/25 | 11/25 | | |
STIMASEP, NCT02059096: Analgesic Effect of Repetitive Transcranial Magnetic Stimulation (rTMS) for Central Neuropathic Pain in Multiple Sclerosis |
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| Recruiting | 3 | 66 | Europe | Repetitive Transcranial Magnetic Stimulation (rTMS) | University Hospital, Clermont-Ferrand | Multiple Sclerosis With Central Neuropathic Pain | 02/23 | 02/23 | | |
| Recruiting | 3 | 140 | Europe | Early palliative care integration | University Hospital, Clermont-Ferrand, Fondation Apicil, Association des foulées de la Haute Lozère, Association CEMSBM, Connaître et Combattre les Myélodysplasies | Acute Myeloid Leukemia, Myelodysplastic Syndrome, Diffuse Large B Cell Lymphoma, Palliative Care | 08/23 | 12/23 | | |
BADDAP, NCT04207411: Efficacy of Repeated Locoregional Anesthetics Blocks With Bupivacaine in Patients Suffering of Chronic Dentoalveolar Pain. |
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| Recruiting | 2 | 50 | Europe | Bupivacaine, Lidocaine | University Hospital, Clermont-Ferrand | Pain | 10/22 | 10/23 | | |
| Completed | 2 | 77 | Europe | DONEPEZIL, PLACEBO | University Hospital, Clermont-Ferrand, Federation Francophone de Cancerologie Digestive | Digestive Oncology, Supportive Care | 01/24 | 01/24 | | |
E-PENEPA, NCT04431778: Evaluation of the Efficacy and Tolerance of Low Doses of Ethosuximide in the Treatment of Peripheral Neuropathic Pain |
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| Recruiting | 2 | 64 | Europe | Ethosuximide, Placebo | University Hospital, Clermont-Ferrand | Peripheral Neuropathic Pain | 11/23 | 12/23 | | |
| Completed | 2 | 45 | Europe | Follow-up of patients with postmenopausal osteoporosis, with or without fractures, requiring initiation of injectable bisphosphonate therapy as part of their usual care, Follow-up of patients with postmenopausal osteoporosis, fractured or not, requiring initiation of injectable bisphosphonate therapy as part of care with magnesium supplementation | University Hospital, Clermont-Ferrand | Osteoporosis, Postmenopausal | 12/24 | 12/24 | | |
TestICUs, NCT03678233: Efficacy of Testosterone Gel to Restore Normal Serum Values of Testosterone During the Acute Phase of Critical Illness in Adult ICU Patients |
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| Recruiting | 2 | 30 | Europe | AndroGel 16.2 mg/L | University Hospital, Clermont-Ferrand | Hypermetabolism in ICU, Loss of Muscle Mass, Functional Disability After ICU, ICU Acquired Hypogonadism, Treatment With Testosterone Gel in ICU | 06/25 | 06/25 | | |
| Terminated | N/A | 37 | Europe | VISIODOL® (Diagnostic tool) | University Hospital, Clermont-Ferrand | Visual Deficiency, Congenital Blindness, Acquired Blindness | 12/20 | 12/20 | | |
RPASP, NCT04561271: Feasability of Foot Reflexology to Alleviate Anxiety in Palliative Care Unit |
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| Not yet recruiting | N/A | 43 | Europe | foot reflexology, toucher massage | University Hospital, Clermont-Ferrand | End Stage Disease | 07/21 | 07/21 | | |
| Recruiting | N/A | 60 | Europe | Biological sample collection | University Hospital, Clermont-Ferrand | Aseptic Abscess Syndrome | 12/24 | 12/25 | | |
| Not yet recruiting | N/A | 400 | Europe | nasopharyngeal swabbing procedure (self swabbing first), nasopharyngeal swabbing procedure (conventionnal swabbing first) | University Hospital, Clermont-Ferrand | Covid19 | 10/21 | 12/21 | | |
| Not yet recruiting | N/A | 100 | Europe | Biological collection with nasopharyngeal samples, saliva, blood, stool and urine | University Hospital, Clermont-Ferrand | Covid19, Contact Case | 11/21 | 02/22 | | |
3DSmoke, NCT04610931: Study of the Effectiveness of a Virtual Reality Treatment in the Management of Smoking Cessation |
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| Recruiting | N/A | 100 | Europe | Virtual Reality-Enhanced Cognitive Behavioral Therapy (VR-CBT), cognitive behavior therapy | University Hospital, Clermont-Ferrand, National Cancer Institute, France | Tobacco Use Cessation | 07/24 | 07/25 | | |
PREVAGREF, NCT04791098: Impact of Infectious Diseases Consultation on Vaccination Coverage Among People Waiting for a Kidney Transplant at the Clermont-Ferrand Hospital |
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| Recruiting | N/A | 150 | Europe | Specific infectious diseases consultation | University Hospital, Clermont-Ferrand | Kidney Transplantation | 03/22 | 04/26 | | |
RESILSTIGMA, NCT05149001: Study Among People Living With HIV and Their Health Professionals of Associated Factors of Resilience to Self-stigma |
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| Completed | N/A | 667 | Europe, RoW | | University Hospital, Clermont-Ferrand, Poitiers University Hospital, Poissy-Saint Germain Hospital, Centre Hospitalier Universitaire Dijon, Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer, Hopital Antoine Beclere, Nantes University Hospital, Hospital, La Roche sur Yon, Hôpital Necker-Enfants Malades, Centre Hospitalier de Bretagne Sud, Reims University Hospital, Groupe Hospitalier de la Rochelle Ré Aunis, Hospital Laennec, Quimper, University Hospital, Brest, Hospital Cornouaille, Quimper, Centre Hospitalier de Cholet, University Hospital, Strasbourg, CH Annecy Genevois, Centre hospitalier de Perpignan, Centre Hospitalier le Mans, Centre Hospitalier VALENCIENNES, Bicetre Hospital, Centre Hospitalier Universitaire de Nice, University Hospital, Marseille, Jacques Lacarin Hospital Center, L'hôpital Nord-Ouest - Villefranche Villefranche sur Saône, Centre Hospitalier Universitaire de Besancon, Hospital, Vannes, Moulins Hospital, Hospital, Montluçon, Centre Hospitalier de Niort, Hôpital Edouard Herriot, Hospital La Source, Orléans, Centre Hospitalier du Pays d'Aix, Hospital Andre Mignot, Le Chesnay, Hôpital Raymond Poincaré, University Hospital, Angers, University Hospital, Pointe-à-Pitre, Centre Hospitalier des Pays de Morlaix, Hospital Foch, Suresnes, Tenon Hospital, Paris, University Hospital of Saint-Etienne, Centre Hospitalier de Saint-Denis, University Hospital, Mulhouse | HIV Infections | 04/22 | 04/22 | | |
IFEH, NCT04846647: Study of the Inappropriate Secretion of FGF23 in Patients Followed in Hospital in a Context of Hypophosphatemia |
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| Completed | N/A | 260 | Europe | unexplained hypophoshatemia | University Hospital, Clermont-Ferrand, DiaSorin ; Saluggia, Italia | Hypophosphatemia Without Immediate Anteriority, Unexplained Hypophosphatemia | 04/22 | 04/22 | | |
| Recruiting | N/A | 120 | Europe | Abbey Pain Scale | University Hospital, Clermont-Ferrand | Stroke, Pain | 05/22 | 06/22 | | |
| Recruiting | N/A | 140 | Europe | laparoscopy, vnotes | University Hospital, Clermont-Ferrand | Gynecologic Surgery | 05/22 | 11/25 | | |
| Terminated | N/A | 23 | Europe | Eccentric rehabilitation sessions | University Hospital, Clermont-Ferrand, Clinique Médicale Cardio-Pneumologique de Durtol | Chronic Heart Failure Patient, Rehabilitation Program | 05/22 | 05/22 | | |
PelviEOS, NCT05224908: Breech Pelvimetry by EOS® Technique With Change of Maternal Position and Delivery Route |
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| Recruiting | N/A | 87 | Europe | EOS | University Hospital, Clermont-Ferrand | EOS, Pregnancy Related, Fetus Fetus, Breech Fetal Presentation | 07/25 | 07/25 | | |
