Sarcoma
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1664 Trials

   

 
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Sarcoma
ChiCTR2200062550: Phase II clinical study of apatinib tablet combined with chemotherapy in neoadjuvant therapy of adult osteosarcoma

Not yet recruiting
2
24
 
Apatinib mesylate tablets combined with chemotherapy
Department of Orthopedics Oncology, Shanghai Changzheng Hospital; Shanghai Changzheng Hospital, Special funds
Osteosarcoma
 
 
ChiCTR2300070397: Phase II single-arm, open-label, multicenter study of radiotherapy combined with Bevacizumab treat patients with postoperative residual/recurrent or inoperable desmoid-type fibromatosis who progressed after first-line close observation

Not yet recruiting
2
20
 
Bevacizumab+radiotherapy
Sichuan Cancer Hospital & Institute; Sichuan Cancer Hospital & Institute, Guangzhou Life Oasis Public Service Center
Desmoid-type fibromatosis
 
 
RAFAS-001, NCT05894018: Brachytherapy (Iodine-125 Seeds) and Fluzoparib Combination Therapy for Advanced Unresectable Soft Tissue Sarcoma

Recruiting
2
32
RoW
Fluzoparib, Radioactive particle implantation
Fujun Zhang
Sarcoma,Soft Tissue, Brachytherapy, Poly(ADP-ribose) Polymerase Inhibitors
06/24
12/24
NCT02846987: Study of Abemaciclib in Dedifferentiated Liposarcoma

Checkmark Results for dedifferentiated liposarcoma
Nov 2018 - Nov 2018: Results for dedifferentiated liposarcoma
Active, not recruiting
2
33
US
Abemaciclib, LY2835219
Memorial Sloan Kettering Cancer Center, Eli Lilly and Company
Sarcoma, Dedifferentiated Liposarcoma
07/24
07/24
NCT02790515: Provision of TCRγδ T Cells and Memory T Cells Plus Selected Use of Blinatumomab in Naïve T-cell Depleted Haploidentical Donor Hematopoietic Cell Transplantation for Hematologic Malignancies Relapsed or Refractory Despite Prior Transplantation

Recruiting
2
52
US
Anti-thymocyte globulin (rabbit), Thymoglobulin®, rabbit ATG, Blinatumomab, Blincyto, Cyclophosphamide, Cytoxan, Fludarabine, Fludara, G-CSF, Filgrastim, Neupogen®, Melphalan, L-phenylalanine mustard, Phenylalanine mustard, L-PAM, L-sarcolysin, Alkeran, Mesna, Mesnex, Rituximab, Rituxan™, Tacrolimus, FK506, Prograf®, Protopic®, Thiotepa, Thioplex® by Immunex, TESPA, TSPA, HPC,A Infusion, Transplant, CliniMACS, Cell Selection System, Sirolimus, Rapamycin, Rapamune®
St. Jude Children's Research Hospital
Acute Lymphoblastic Leukemia (ALL), Acute Myeloid Leukemia (AML), Myeloid Sarcoma, Chronic Myeloid Leukemia (CML), Juvenile Myelomonocytic Leukemia (JMML), Myelodysplastic Syndrome (MDS), Non-Hodgkin Lymphoma (NHL)
07/24
07/25
CEMangio, NCT04873375: Cemiplimab for Secondary Angiosarcomas

Recruiting
2
18
Europe
Cemiplimab, LIBTAYO
Radboud University, Genzyme Europe B.V.
Secondary Angiosarcoma, Locally Advanced Sarcoma, Metastasis
07/24
10/25
NCT04554836: MoLiMoR - A Study With FOLFIRI-based First-line Therapy With or Without Intermittent Cetuximab

Active, not recruiting
2
144
Europe
Cetuximab, FOLFIRI
TheraOp
Adenocarcinoma of the Colon, Adenocarcinoma of the Rectum
07/24
10/24
DiTuSarc, NCT05080790: Treatment With Dinutuximab Beta, Zoledronic Acid and Low-dose Interleukin (IL-2) in Patients With Leiomyosarcoma

Recruiting
2
10
Europe
Dinutuximab Beta, Zoledronic acid, Interleukin-2
Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest, EUSA Pharma, Inc.
Leiomyosarcoma
07/24
07/24
SYNERGIAS, NCT05131386: Multicohort Trial of Trabectedin and Low-dose Radiation Therapy in Advanced/Metastatic Sarcomas

Recruiting
2
85
Europe
Trabectedin, Yondelis
Grupo Espanol de Investigacion en Sarcomas
Soft Tissue Sarcoma, Bone Tumors, Small Round-cell Sarcomas
07/24
07/24
NCT03241745: A Study of Nivolumab in Selected Uterine Cancer Patients

Completed
2
35
US
Nivolumab
Memorial Sloan Kettering Cancer Center, Bristol-Myers Squibb
Uterine Cancer, Endometrial Carcinoma, Carcinosarcoma, Leiomyosarcoma, Undifferentiated Sarcoma, High Grade Endometrial Stromal Sarcoma, Clear Cell Carcinoma
04/24
04/24
NCT05235100: Preoperative IMRT With Concurrent Apatinib for Localised Extremity or Trunk Sarcoma

Recruiting
2
30
RoW
Apatinib Mesylate
Chinese Academy of Medical Sciences
Sarcoma,Soft Tissue, Extremity, Trunk, Intensity-modulated Radiotherapy, Targetd Therapy, Major Wound Complications
08/24
12/24
NCT05854966: CPI-613 Given With Metformin in Patients With Relapsed or Refractory Acute Myeloid Leukemia (AML)

Not yet recruiting
2
17
US
CPI 613, Devimistat, Metformin, Metformin pill, Blood draws, Bone marrow biopsy
Wake Forest University Health Sciences, National Cancer Institute (NCI), Cornerstone Pharmaceuticals
Acute Myeloid Leukemia, in Relapse, Acute Myeloid Leukemia Refractory, Granulocytic Sarcoma
04/25
09/25
NCT06326346: GIST Oral Paclitaxel(Liporaxel)

Not yet recruiting
2
28
RoW
Liporaxel
Asan Medical Center
Gastrointestinal Stromal Tumors
03/27
03/27
NCT05542433: Phase II Study of Chiauranib Capsule in Advanced or Unresectable Soft Tissue Sarcoma

Recruiting
2
30
RoW
Chiauranib, Chiauranib Capsules
Sun Yat-sen University, Shenzhen Chipscreen Biosciences Co.Ltd
Soft Tissue Sarcoma
08/24
08/24
NCT06110650: A Study of Surufatinib in the Treatment of Advanced Soft Tissue Sarcoma

Not yet recruiting
2
29
NA
Surufatinib
Fudan University
Soft Tissue Sarcoma Adult
08/24
08/25
NCT00496522: Proton Beam Therapy for Chondrosarcoma

Active, not recruiting
2
15
US
Proton Beam Therapy
M.D. Anderson Cancer Center
Chondrosarcoma
08/24
08/24
NCT03197506: Pembrolizumab and Standard Therapy in Treating Patients With Glioblastoma

Suspended
2
52
US
External Beam Radiation Therapy, Definitive Radiation Therapy, EBRT, External Beam Radiation, External Beam Radiotherapy, External Beam RT, external radiation, External Radiation Therapy, external-beam radiation, Radiation, External Beam, Teleradiotherapy, Teletherapy, Teletherapy Radiation, Laboratory Biomarker Analysis, Pembrolizumab, Keytruda, Lambrolizumab, MK-3475, SCH 900475, Radiation Therapy, Cancer Radiotherapy, ENERGY_TYPE, Irradiate, Irradiated, Irradiation, Radiation, Radiation Therapy, NOS, Radiotherapeutics, Radiotherapy, RT, Therapy, Radiation, Temozolomide, CCRG-81045, Imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3, 4-dihydro-3-methyl-4-oxo-, M & B 39831, M and B 39831, Methazolastone, RP-46161, SCH 52365, Temcad, Temodal, Temodar, Temomedac, TMZ, Therapeutic Conventional Surgery
Mayo Clinic, National Cancer Institute (NCI)
Glioblastoma, Gliosarcoma, Supratentorial Glioblastoma
08/24
08/24
NCT03819985: Shorter Course, Hypofractionated Pre-Surgery Radiation Therapy in Treating Patients With Localized, Resectable Soft Tissue Sarcoma of the Extremity of Superficial Trunk

Active, not recruiting
2
122
US
Hypofractionated Radiation Therapy, Hypofractionated Radiotherapy, Hypofractionated, Quality-of-Life Assessment, Quality of Life Assessment, Questionnaire Administration
M.D. Anderson Cancer Center, National Cancer Institute (NCI)
Resectable Soft Tissue Sarcoma, Stage I Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8, Stage IA Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8, Stage IB Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8, Stage II Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8, Stage III Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8, Stage IIIA Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8, Stage IIIB Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8
08/24
08/24
NCT03872427: Testing Whether Cancers With Specific Mutations Respond Better to Glutaminase Inhibitor, Telaglenastat Hydrochloride, Anti-Cancer Treatment, BeGIN Study

Active, not recruiting
2
108
US
Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Computed Tomography, CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, Computerized Tomography (CT) scan, CT, CT Scan, tomography, Magnetic Resonance Imaging, Magnetic Resonance, Magnetic Resonance Imaging (MRI), Magnetic resonance imaging (procedure), Magnetic Resonance Imaging Scan, Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance, MR, MR Imaging, MRI, MRI Scan, MRIs, NMR Imaging, NMRI, Nuclear Magnetic Resonance Imaging, sMRI, Structural MRI, Pharmacodynamic Study, PHARMACODYNAMIC, Pharmacodynamic (PD) study, Positron Emission Tomography, Medical Imaging, Positron Emission Tomography, PET, PET Scan, Positron emission tomography (procedure), Positron Emission Tomography Scan, Positron-Emission Tomography, proton magnetic resonance spectroscopic imaging, PT, Telaglenastat Hydrochloride, CB-839 HCl, Glutaminase Inhibitor CB-839 Hydrochloride
National Cancer Institute (NCI)
Advanced Malignant Solid Neoplasm, Metastatic Malignant Solid Neoplasm, NF1 Mutation Positive Malignant Peripheral Nerve Sheath Tumor, Unresectable Malignant Solid Neoplasm
08/24
08/24
ChiCTR2200062943: Envafolimab combined with AI for the first-line treatment of advanced soft tissue sarcoma: a prospective, open-label, single arm, single-center clinical study

Not yet recruiting
2
30
 
Envafolimab combined with AI
Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences; Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Partly self-funded, partly provied by simcere.
Soft tissue sarcoma
 
 
NCT03282344: A Study of NKTR-214 in Combination With Nivolumab in Patients With Metastatic and/or Locally Advanced Sarcoma

Active, not recruiting
2
88
US
NKTR-214, Nivolumab
Memorial Sloan Kettering Cancer Center, M.D. Anderson Cancer Center, Stanford University, Rockefeller University
SARCOMA
09/25
09/25
CA017-056, NCT04106414: Study of BMS-986205 and Nivolumab in Endometrial Cancer or Endometrial Carcinosarcoma That Has Not Responded to Treatment

Active, not recruiting
2
24
US
Nivolumab, BMS- 986205
Memorial Sloan Kettering Cancer Center, Bristol-Myers Squibb
Endometrial Adenocarcinoma, Endometrial Carcinosarcoma
09/24
09/24
NCT04040205: Abemaciclib for Bone and Soft Tissue Sarcoma With Cyclin-Dependent Kinase (CDK) Pathway Alteration

Recruiting
2
44
US
Abemaciclib, Verzenio
Medical College of Wisconsin
Chondrosarcoma, Osteosarcoma, Soft Tissue Sarcoma
06/25
06/26
AGADIR, NCT03915678: Atezolizumab Combined With BDB001 AnD Immunogenic Radiotherapy in Patients With Advanced Solid Tumors

Recruiting
2
247
Europe
Association atezolizumab + BDB001 + RT, Association atezolizumab + BDB001+ RT
Institut Bergonié, Roche Pharma AG, National Cancer Institute, France, Eikon Therapeutics
Solid Tumor, Adult, Pancreatic Cancer, Virus-associated Tumors, Non Small Cell Lung Cancer, Melanoma, Bladder Cancer, Triple Negative Breast Cancer
09/24
03/26
NCT04776525: Sequential Neoadjuvant Chemotherapy in Soft Tissue Sarcoma

Recruiting
2
49
Europe
Ifosfamide, Holoxan, Doxorubicin, Adriamycin
Oslo University Hospital, Haukeland University Hospital
Soft Tissue Sarcoma
09/26
09/36
ISG-MCS, NCT04305548: Study on Trabectedin in Advanced Rearranged Mesenchymal Chondrosarcoma

Recruiting
2
16
Europe
Trabectedin
Italian Sarcoma Group, PharmaMar
Mesenchymal Chondrosarcoma
09/24
12/24
TRUST, NCT04874311: Bintrafusp Alfa and Doxorubicin Hydrochloride in Treating Patients With Advanced Sarcoma

Recruiting
2
80
Europe
Bintrafusp alfa, Doxorubicin
Institut Bergonié, Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany
Advanced Soft-tissue Sarcoma, Metastatic Soft-tissue Sarcoma
09/24
03/25
NCT05549921: Phase II Study of TAEST16001 in Soft Tissue Sarcoma

Recruiting
2
70
RoW
NY-ESO-1(TCR Affinity Enhancing Specific T cell Therapy)
Sun Yat-sen University, Guangdong Xiangxue Precision Medical Technology Co., Ltd.
Soft Tissue Sarcoma
09/24
09/24
ChiCTR2200062868: CDK4 Inhibitor Dalpiciclib in Patients with Advanced CDK4-Amplifified Well-Differentiated or Dedifferentiated Liposarcoma: a prospective, open-label, single-arm and multi-center clinical study

Not yet recruiting
2
40
 
Dalpiciclib
Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences; Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, partly self-funded, partly provied by jiangsu hengrui pharmaceutical co.
Well-Differentiated or Dedifferentiated Liposarcoma
 
 
PAMSARC, NCT06456359: Pasireotide as Maintenance Treatment in Synovial Sarcoma and Desmoplastic Small Round Cell Tumor

Not yet recruiting
2
28
Europe
Signifor, ATC-Code: H01CB05
University Hospital Heidelberg
Desmoplastic Small Round Cell Tumor, Synovial Sarcoma
10/27
10/28
NCT03213704: Larotrectinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With NTRK Fusions (A Pediatric MATCH Treatment Trial)

Active, not recruiting
2
49
US
Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Bone Marrow Aspiration and Biopsy, Bone Scan, Bone Scintigraphy, Computed Tomography, CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, Computerized Tomography (CT) scan, CT, CT Scan, tomography, Larotrectinib Sulfate, ARRY 470 Sulfate, LOXO 101 Sulfate, LOXO-101 Sulfate, Vitrakvi, Magnetic Resonance Imaging, Magnetic Resonance, Magnetic Resonance Imaging (MRI), Magnetic resonance imaging (procedure), Magnetic Resonance Imaging Scan, Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance, MR, MR Imaging, MRI, MRI Scan, MRIs, NMR Imaging, NMRI, Nuclear Magnetic Resonance Imaging, sMRI, Structural MRI, Radionuclide Imaging, NM, Nuclear Medicine, nuclear medicine scan, radioimaging, Radionuclide Scanning, Scan, Scintigraphy, X-Ray Imaging, Conventional X-Ray, Diagnostic Radiology, Medical Imaging, X-Ray, Plain film radiographs, Radiographic Imaging, Radiographic imaging procedure (procedure), Radiography, RG, Static X-Ray, X-Ray
National Cancer Institute (NCI)
Advanced Malignant Solid Neoplasm, Recurrent Ependymoma, Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor, Recurrent Glioma, Recurrent Hepatoblastoma, Recurrent Kidney Wilms Tumor, Recurrent Langerhans Cell Histiocytosis, Recurrent Malignant Germ Cell Tumor, Recurrent Malignant Glioma, Recurrent Malignant Solid Neoplasm, Recurrent Medulloblastoma, Recurrent Neuroblastoma, Recurrent Non-Hodgkin Lymphoma, Recurrent Osteosarcoma, Recurrent Rhabdoid Tumor, Recurrent Rhabdomyosarcoma, Recurrent Soft Tissue Sarcoma, Refractory Ependymoma, Refractory Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor, Refractory Glioma, Refractory Hepatoblastoma, Refractory Langerhans Cell Histiocytosis, Refractory Malignant Germ Cell Tumor, Refractory Malignant Glioma, Refractory Malignant Solid Neoplasm, Refractory Medulloblastoma, Refractory Neuroblastoma, Refractory Non-Hodgkin Lymphoma, Refractory Osteosarcoma, Refractory Primary Central Nervous System Neoplasm, Refractory Rhabdoid Tumor, Refractory Rhabdomyosarcoma, Refractory Soft Tissue Sarcoma
09/24
09/24
NCT03213652: Ensartinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With ALK or ROS1 Genomic Alterations (A Pediatric MATCH Treatment Trial)

Recruiting
2
98
US, RoW
Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Bone Marrow Aspiration and Biopsy, Bone Scan, Bone Scintigraphy, Computed Tomography, CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, Computerized Tomography (CT) scan, CT, CT Scan, tomography, Ensartinib, X-396, Laboratory Biomarker Analysis, Magnetic Resonance Imaging, Magnetic Resonance, Magnetic Resonance Imaging (MRI), Magnetic resonance imaging (procedure), Magnetic Resonance Imaging Scan, Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance, MR, MR Imaging, MRI, MRI Scan, MRIs, NMR Imaging, NMRI, Nuclear Magnetic Resonance Imaging, sMRI, Structural MRI, Pharmacological Study, Positron Emission Tomography, Medical Imaging, Positron Emission Tomography, PET, PET Scan, Positron emission tomography (procedure), Positron Emission Tomography Scan, Positron-Emission Tomography, proton magnetic resonance spectroscopic imaging, PT, Radionuclide Imaging, NM, Nuclear Medicine, nuclear medicine scan, radioimaging, Radionuclide Scanning, Scan, Scintigraphy, X-Ray Imaging, Conventional X-Ray, Diagnostic Radiology, Medical Imaging, X-Ray, Plain film radiographs, Radiographic Imaging, Radiographic imaging procedure (procedure), Radiography, RG, Static X-Ray, X-Ray
National Cancer Institute (NCI), Children's Oncology Group
Advanced Malignant Solid Neoplasm, Malignant Solid Neoplasm, Recurrent Ependymoma, Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor, Recurrent Hepatoblastoma, Recurrent Langerhans Cell Histiocytosis, Recurrent Malignant Germ Cell Tumor, Recurrent Malignant Glioma, Recurrent Malignant Solid Neoplasm, Recurrent Medulloblastoma, Recurrent Neuroblastoma, Recurrent Non-Hodgkin Lymphoma, Recurrent Osteosarcoma, Recurrent Primary Central Nervous System Neoplasm, Recurrent Rhabdoid Tumor, Recurrent Rhabdomyosarcoma, Recurrent Soft Tissue Sarcoma, Refractory Ependymoma, Refractory Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor, Refractory Hepatoblastoma, Refractory Langerhans Cell Histiocytosis, Refractory Malignant Germ Cell Tumor, Refractory Malignant Glioma, Refractory Malignant Solid Neoplasm, Refractory Medulloblastoma, Refractory Neuroblastoma, Refractory Non-Hodgkin Lymphoma, Refractory Osteosarcoma, Refractory Primary Central Nervous System Neoplasm, Refractory Rhabdoid Tumor, Refractory Rhabdomyosarcoma, Refractory Soft Tissue Sarcoma, Wilms Tumor
09/24
09/24
A091902, NCT04339738: Testing the Addition of Nivolumab to Chemotherapy in Treatment of Soft Tissue Sarcoma

Active, not recruiting
2
90
US, RoW
Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Cabozantinib S-malate, BMS-907351, Cabometyx, Cometriq, XL-184, XL184, Computed Tomography, CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, Computerized Tomography (CT) scan, CT, CT Scan, tomography, FDG-Positron Emission Tomography, FDG, FDG-PET, FDG-PET Imaging, Magnetic Resonance Imaging, Magnetic Resonance, Magnetic Resonance Imaging (MRI), Magnetic resonance imaging (procedure), Magnetic Resonance Imaging Scan, Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance, MR, MR Imaging, MRI, MRI Scan, MRIs, NMR Imaging, NMRI, Nuclear Magnetic Resonance Imaging, sMRI, Structural MRI, Nivolumab, ABP 206, BCD-263, BMS-936558, CMAB819, MDX-1106, NIVO, Nivolumab Biosimilar ABP 206, Nivolumab Biosimilar BCD-263, Nivolumab Biosimilar CMAB819, ONO-4538, Opdivo, Paclitaxel, Anzatax, Asotax, Bristaxol, Praxel, Taxol, Taxol Konzentrat, Quality-of-Life Assessment, Quality of Life Assessment, Questionnaire Administration
National Cancer Institute (NCI)
Skin Angiosarcoma, Skin Radiation-Related Angiosarcoma, Visceral Angiosarcoma
09/24
09/24
TAGGED, NCT04535271: Metronomic Trabectedin, Gemcitabine, and Dacarbazine for Leiomyosarcoma

Recruiting
2
80
US
Trabectedin, Gemcitabine, Dacarbazine
Sarcoma Oncology Research Center, LLC
Leiomyosarcoma
09/24
12/24
NCT06445166: Propranolol for the Treatment of Kaposi Sarcoma in Adults

Not yet recruiting
2
25
US
Propranolol Hydrochloride
Washington University School of Medicine
Kaposi Sarcoma
03/27
09/27
NCT00186992: Radiation Therapy to Treat Musculoskeletal Tumors

Active, not recruiting
2
202
US
image-guided radiotherapy
St. Jude Children's Research Hospital, Lance Armstrong Foundation
Sarcoma, Ewing's, Rhabdomyosarcoma, Soft Tissue Sarcoma, Musculoskeletal Tumors
10/24
10/24
NCT00077285: Irinotecan and Carboplatin as Upfront Window Therapy in Treating Patients With Newly Diagnosed Intermediate-Risk or High-Risk Rhabdomyosarcoma

Active, not recruiting
2
65
US
filgrastim, carboplatin, cyclophosphamide, dexrazoxane hydrochloride, doxorubicin hydrochloride, etoposide, ifosfamide, irinotecan hydrochloride, vincristine sulfate, conventional surgery, radiation therapy
Memorial Sloan Kettering Cancer Center, National Cancer Institute (NCI)
Sarcoma
10/24
10/24
SARCOME13, NCT03643133 / 2017-001165-24: Mifamurtide Combined With Post-operative Chemotherapy for Newly Diagnosed High Risk Osteosarcoma Patients

Active, not recruiting
2
60
Europe
Mifamurtide, MEPACT, EI or M-API regimen depending on patient age
UNICANCER
Osteosarcoma
10/24
10/33
NCT04416568: Study of Nivolumab and Ipilimumab in Children and Young Adults With INI1-Negative Cancers

Recruiting
2
45
US
Nivolumab, OPDIVO, Ipilimumab, YERYOY
Dana-Farber Cancer Institute, Gateway for Cancer Research
Malignant Rhabdoid Tumor, Rhabdoid Tumor of the Kidney, Epithelioid Sarcoma, Chordoma (Poorly Differentiated or De-differentiated), Atypical Teratoid/Rhabdoid Tumor, Other INI1 Negative Tumors (With PI Approval), Other SMARCA4-deficient Malignant Tumors (With PI Approval)
10/24
10/25
TARSARC, NCT04807816: Targeting ATR in Soft-tissue Sarcomas

Recruiting
2
72
Europe
Association of berzosertib with gemcitabine, Experimental, Gemcitabine, Control
Institut Bergonié, Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany
Leiomyosarcoma, Adult
10/24
04/26
NCT05465954: Efineptakin Alfa and Pembrolizumab for the Treatment of Recurrent Glioblastoma

Recruiting
2
34
US
Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Efineptakin alfa, GX-I7, Hyleukin-7 (TM), Il-7 Hybrid Fc, IL-7-hyFc, NT-I7, rhIL-7-hyFc, TJ 107, TJ-107, TJ107, Pembrolizumab, Keytruda, Lambrolizumab, MK-3475, SCH 900475
Mayo Clinic, NeoImmune Tech, Merck Sharp & Dohme LLC
High Grade Astrocytic Tumor, Recurrent Glioblastoma, IDH-Wildtype, Recurrent Gliosarcoma
10/24
10/25
SWOG S1609, NCT02834013: Nivolumab and Ipilimumab in Treating Patients With Rare Tumors

Checkmark From cohort 36 of DART trial in combination with Yervoy for metaplastic breast cancer
Jun 2020 - Jun 2020: From cohort 36 of DART trial in combination with Yervoy for metaplastic breast cancer
Checkmark From cohort 36 of DART trial in combination with Opdivo for metaplastic breast cancer
Jun 2020 - Jun 2020: From cohort 36 of DART trial in combination with Opdivo for metaplastic breast cancer
Checkmark In combination with yervoy in aggressive neuroendocrine tumors
More
Active, not recruiting
2
818
US, RoW
Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Computed Tomography, CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, Computerized Tomography (CT) scan, CT, CT Scan, tomography, Echocardiography, EC, Ipilimumab, Anti-Cytotoxic T-Lymphocyte-Associated Antigen-4 Monoclonal Antibody, BMS-734016, Ipilimumab Biosimilar CS1002, MDX-010, MDX-CTLA4, Yervoy, Magnetic Resonance Imaging, Magnetic Resonance, Magnetic Resonance Imaging (MRI), Magnetic resonance imaging (procedure), Magnetic Resonance Imaging Scan, Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance, MR, MR Imaging, MRI, MRI Scan, MRIs, NMR Imaging, NMRI, Nuclear Magnetic Resonance Imaging, sMRI, Structural MRI, Nivolumab, ABP 206, BCD-263, BMS-936558, CMAB819, MDX-1106, NIVO, Nivolumab Biosimilar ABP 206, Nivolumab Biosimilar BCD-263, Nivolumab Biosimilar CMAB819, ONO-4538, Opdivo
National Cancer Institute (NCI)
Acinar Cell Carcinoma, Adenoid Cystic Carcinoma, Adrenal Cortical Carcinoma, Adrenal Gland Pheochromocytoma, Anal Canal Neuroendocrine Carcinoma, Anal Canal Undifferentiated Carcinoma, Angiosarcoma, Apocrine Neoplasm, Appendix Mucinous Adenocarcinoma, Bartholin Gland Transitional Cell Carcinoma, Basal Cell Carcinoma, Bladder Adenocarcinoma, Breast Metaplastic Carcinoma, Cervical Adenocarcinoma, Cholangiocarcinoma, Chordoma, Colorectal Squamous Cell Carcinoma, Desmoid Fibromatosis, Endometrial Transitional Cell Carcinoma, Endometrioid Adenocarcinoma, Esophageal Neuroendocrine Carcinoma, Esophageal Undifferentiated Carcinoma, Extrahepatic Bile Duct Carcinoma, Extramammary Paget Disease, Fallopian Tube Adenocarcinoma, Fallopian Tube Transitional Cell Carcinoma, Fibromyxoid Tumor, Gallbladder Carcinoma, Gastric Neuroendocrine Carcinoma, Gastric Squamous Cell Carcinoma, Gastric Undifferentiated Carcinoma, Gastrointestinal Stromal Tumor, Gestational Trophoblastic Tumor, Giant Cell Carcinoma, Human Papillomavirus-Independent Cervical Adenocarcinoma, Clear Cell-Type, Intestinal Neuroendocrine Carcinoma, Intrahepatic Cholangiocarcinoma, Lung Neuroendocrine Tumor, Lung Sarcomatoid Carcinoma, Major Salivary Gland Carcinoma, Malignant Odontogenic Neoplasm, Malignant Peripheral Nerve Sheath Tumor, Malignant Solid Neoplasm, Malignant Testicular Sex Cord-Stromal Tumor, Metastatic Malignant Neoplasm of Unknown Primary, Metastatic Pituitary Neuroendocrine Tumor, Minimally Invasive Lung Adenocarcinoma, Mixed Mesodermal (Mullerian) Tumor, Mucinous Adenocarcinoma, Mucinous Cystadenocarcinoma, Nasal Cavity Adenocarcinoma, Nasal Cavity Carcinoma, Nasopharyngeal Carcinoma, Nasopharyngeal Low Grade Papillary Adenocarcinoma, Nasopharyngeal Undifferentiated Carcinoma, Oral Cavity Carcinoma, Oropharyngeal Undifferentiated Carcinoma, Ovarian Adenocarcinoma, Ovarian Germ Cell Tumor, Ovarian Mucinous Adenocarcinoma, Ovarian Squamous Cell Carcinoma, Ovarian Transitional Cell Carcinoma, Pancreatic Acinar Cell Carcinoma, Pancreatic Neuroendocrine Carcinoma, Paraganglioma, Paranasal Sinus Adenocarcinoma, Paranasal Sinus Carcinoma, Parathyroid Gland Carcinoma, PEComa, Penile Squamous Cell Carcinoma, Peritoneal Mesothelial Neoplasm, Placental Choriocarcinoma, Primary Peritoneal High Grade Serous Adenocarcinoma, Pseudomyxoma Peritonei, Rare Disorder, Scrotal Squamous Cell Carcinoma, Seminal Vesicle Adenocarcinoma, Seminoma, Serous Cystadenocarcinoma, Small Intestinal Adenocarcinoma, Small Intestinal Squamous Cell Carcinoma, Spindle Cell Neoplasm, Teratoma With Somatic-Type Malignancy, Testicular Non-Seminomatous Germ Cell Tumor, Thyroid Gland Carcinoma, Tracheal Carcinoma, Transitional Cell Carcinoma, Ureter Adenocarcinoma, Ureter Squamous Cell Carcinoma, Urethral Adenocarcinoma, Urethral Squamous Cell Carcinoma, Vaginal Adenocarcinoma, Vaginal Squamous Cell Carcinoma, Not Otherwise Specified, Vulvar Carcinoma
05/26
05/26
Actuate 1801, NCT03678883: 9-ING-41 in Patients With Advanced Cancers

Active, not recruiting
2
350
Europe, Canada, US
9-ING-41, Gemcitabine - 21 day cycle, Gemzar, Doxorubicin., Doxil, Adriamycin, Lomustine, CCNU, Gleostine, Carboplatin., Paraplatin, Nab paclitaxel., Abraxane, Protein-bound paclitaxel, Nanoparticle albumin-bound paclitaxel, Paclitaxel., Taxol, Gemcitabine - 28 day cycle, Irinotecan, Camptosar
Actuate Therapeutics Inc.
Cancer, Pancreatic Cancer, Sarcoma, Renal Cancer, Refractory Cancer, Refractory Neoplasm, Refractory Non-Hodgkin Lymphoma, Pancreatic Adenocarcinoma, Resistant Cancer, Neoplasm Metastasis, Neoplasm of Bone, Neoplasm, Breast, Neoplasm of Lung, Neoplasms,Colorectal, Neoplasms Pancreatic, Malignant Glioma, Malignancies, Malignancies Multiple, Bone Metastases, Bone Neoplasm, Bone Cancer, Pancreas Cancer, Pancreatic Neoplasms, Breast Neoplasms, Acute T Cell Leukemia Lymphoma
11/24
11/25
NCT04624178: A Study of Rucaparib and Nivolumab in People With Leiomyosarcoma

Active, not recruiting
2
20
US
Rucaparib, Nivolumab
Memorial Sloan Kettering Cancer Center, Bristol-Myers Squibb, Clovis Oncology, Inc.
Leiomyosarcoma
11/24
11/24
FIBROSARC USA, NCT03420014: Treatment of Metastatic Soft Tissue Sarcoma (STS) Patients

Recruiting
2
114
US
Doxorubicin, L19TNF plus doxorubicin
Philogen S.p.A.
Leiomyosarcoma
12/24
12/25
NCT03972930: Hypofractionated Radiotherapy for Soft Tissue Sarcomas

Active, not recruiting
2
48
US
Hypofractionated Radiotherapy
University of Wisconsin, Madison
Soft Tissue Sarcoma
12/24
12/27
NCT03993106 / 2017-001828-22: A Study of sEphB4-HSA in Kaposi Sarcoma

Recruiting
2
65
US
sEphB4-HSA
Vasgene Therapeutics, Inc
Kaposi Sarcoma
12/24
06/25
ICGTM, NCT04719156: Fluorescent Intra-operative Tumor Margin Examination

Recruiting
2
110
US
Indocyanine green solution administered at 2.0mg/kg., Indocyanine Green for Injection, Stryker SPY-PHI Imaging Device, Stryker SPY portable Imaging System
Kurt Weiss, Stryker Nordic
Sarcoma
12/24
06/25
NACHO COBI, NCT04079179: Cobimetinib in Refractory Langerhans Cell Histiocytosis (LCH), and Other Histiocytic Disorders

Recruiting
2
90
US
Cobimetinib, COTELLIC, RO5514041
Carl Allen, Baylor College of Medicine, North American Consortium for Histiocytosis, Genentech, Inc.
Langerhan's Cell Histiocytosis, Juvenile Xanthogranuloma, Erdheim-Chester Disease, Rosai Dorfman Disease, Neuro-Degenerative Disease, Histiocytic Sarcoma, Histiocytic Disorders, Malignant
12/24
12/29
NCT05656144: Cadonilimab in the Treatment of Advanced Soft Tissue Sarcoma

Not yet recruiting
2
49
NA
Cadonilimab
Peking University Cancer Hospital & Institute
Soft Tissue Sarcoma
12/24
06/25
EPOCH, NCT05619913: Eribulin and Pembrolizumab in Ovarian/Uterine Carcinosarcoma

Recruiting
2
30
Europe, Canada, RoW
Eribulin Mesylate, Halaven, Pembrolizumab, Keytruda
Australia New Zealand Gynaecological Oncology Group, Eisai Inc., Merck Sharp & Dohme LLC
Ovarian Carcinosarcoma, Uterine Carcinosarcoma
12/24
12/26
NCT05952128: Phase Ib/II Study of Fluzoparib in Combination With Dalpiciclib in Patients With Locally Advanced or Metastatic Sarcoma

Recruiting
2
50
RoW
Fluzoparib+ Dalpiciclib
Sun Yat-sen University, Jiangsu Hengrui Pharmaceutical Co., Ltd.
Sarcoma
12/24
12/25
NCT06125171: Tucidinostat Plus Apatinib for Advanced Osteosarcoma

Not yet recruiting
2
46
NA
Tucidinostat, Apatinib
Wuhan Union Hospital, China
Osteosarcoma
12/24
12/25
NCT05493215: Imatinib TDM in GIST

Recruiting
2
28
US
Imatinib, Gleevec
Reema A. Patel
Gastrointestinal Stromal Tumors
12/25
12/25
NCT06447103: An Investigational Scan (89Zr-DFO-GmAb PET/CT) Compared to Contrast-Enhanced CT for the Detection of Recurrent Clear Cell Renal Cell Cancer After Surgery Comparing Carbonic Anhydrase IX (CAIX) PET CT to Conventional PET CT for Post-Op Staging in Kidney Cancer

Not yet recruiting
2
91
US
Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Bone Scan, Bone Scintigraphy, Computed Tomography, CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, Computerized Tomography (CT) scan, CT, CT Scan, tomography, Magnetic Resonance Imaging, Magnetic Resonance, Magnetic Resonance Imaging (MRI), Magnetic resonance imaging (procedure), Magnetic Resonance Imaging Scan, Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance, MR, MR Imaging, MRI, MRI Scan, MRIs, NMR Imaging, NMRI, Nuclear Magnetic Resonance Imaging, sMRI, Structural MRI, Positron Emission Tomography, Medical Imaging, Positron Emission Tomography, PET, PET Scan, Positron emission tomography (procedure), Positron Emission Tomography Scan, Positron-Emission Tomography, proton magnetic resonance spectroscopic imaging, PT, Questionnaire Administration, Zirconium Zr 89 Girentuximab, 89Zr-DFO-TFP-girentuximab, 89Zr-girentuximab, 89Zr-TLX250, Zirconium Zr 89 cG250, Zirconium Zr 89-TLX250
Jonsson Comprehensive Cancer Center, Telix Pharmaceuticals (Innovations) Pty Limited
Clear Cell Renal Cell Carcinoma, Sarcomatoid Renal Cell Carcinoma, Stage II Renal Cell Cancer, Stage III Renal Cell Cancer, Stage IV Renal Cell Cancer
12/29
12/30
A082101, NCT05647265: Testing the Addition of Immunotherapy Before Surgery for Patients With Sarcomatoid Mesothelioma

Recruiting
2
26
US
Nivolumab, 946414-94-4, BMS-936558, CMAB819, MDX-1106, NIVO, NIVOLUMAB, Nivolumab, Nivolumab Biosimilar CMAB819, ONO-4538, Opdivo, Ipilimumab, 477202-00-9, Anti-Cytotoxic T-Lymphocyte-Associated Antigen-4 Monoclonal Antibody, BMS-734016, IPILIMUMAB, ipilimumab, Ipilimumab Biosimilar CS1002, MDX-010, MDX-010, MDX-CTLA4, Yervoy, Surgical Procedure, Computed Tomography, CAT, CAT Scan,, Magnetic Resonance Imaging, MRI, Positron Emission Tomography, Medical Imaging, PET, Pet Scan
Alliance for Clinical Trials in Oncology, National Cancer Institute (NCI)
Pleural Biphasic Mesothelioma, Pleural Sarcomatoid Mesothelioma
12/24
12/24
ChiCTR2100053490: A phase 2 study of Surufatinib in patients after first line standard chemotherapy or Anlotinib treatment failure of soft tissue sarcoma

Recruiting
2
64
 
Surufatinib+Gemcitabine ;Surufatinib
Zhongshan Hospital, Fudan University; Zhongshan Hospital, Fudan University, Part of self-raised, part of Hutchison Whampoa Pharmaceuticals (Shanghai) Co., Ltd.
Soft Tissue Sarcoma
 
 
ChiCTR2100054711: Anlotinib combined with AI followed by anlotinib sequential therapy for the first-line treatment of recurrent/metastatic soft tissue sarcoma: a prospective, open-label, single arm, single-center clinical study

Recruiting
2
50
 
Anlotinib combined with AI followed by Anlotinib sequential therapy
Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences; Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, partly self-funded, partly provied by CTTQ
soft tissue Sarcoma
 
 
NCT05147558: A Study of Pembrolizumab With Lenvatinib in Women With Advanced Uterine Carcinosarcoma

Recruiting
2
40
US
Pembrolizumab, Lenvatinib
Memorial Sloan Kettering Cancer Center, Merck Sharp & Dohme LLC
Uterine Carcinosarcoma, Advanced Uterine Carcinosarcoma
12/24
12/24
NCT02815995: Multi-Arm Study to Test the Efficacy of Immunotherapeutic Agents in Multiple Sarcoma Subtypes

Completed
2
56
US
Durvalumab, Tremelimumab
M.D. Anderson Cancer Center, MedImmune LLC
Advanced and/or Metastatic Sarcoma
06/24
06/24
STARTRK-2, NCT02568267 / 2015-003385-84: Basket Study of Entrectinib (RXDX-101) for the Treatment of Patients With Solid Tumors Harboring NTRK 1/2/3 (Trk A/B/C), ROS1, or ALK Gene Rearrangements (Fusions)

Checkmark From STARTRK-2 trial in NTRK+ solid tumors
Oct 2019 - Oct 2019: From STARTRK-2 trial in NTRK+ solid tumors
Checkmark STARTRK-2 trial in NTRK+ solid tumors at ESMO 2018 [screenshot]
Oct 2018 - Oct 2018: STARTRK-2 trial in NTRK+ solid tumors at ESMO 2018 [screenshot]
Checkmark Integrated analysis of 3 trials (STARTRK-2, STARTRK-1, ALKA-372-001) in NTRK fusion-positive solid tumors
More
Active, not recruiting
2
534
Europe, Japan, US, RoW
Entrectinib, RXDX-101
Hoffmann-La Roche
Breast Cancer, Cholangiocarcinoma, Colorectal Cancer, Head and Neck Neoplasms, Lymphoma, Large-Cell, Anaplastic, Melanoma, Neuroendocrine Tumors, Non-Small Cell Lung Cancer, Ovarian Cancer, Pancreatic Cancer, Papillary Thyroid Cancer, Primary Brain Tumors, Renal Cell Carcinoma, Sarcomas, Salivary Gland Cancers, Adult Solid Tumor
12/24
04/25
NCT04195399: A Study of a New Drug, Nirogacestat, for Treating Desmoid Tumors That Cannot be Removed by Surgery

Active, not recruiting
2
35
Canada, US, RoW
Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Computed Tomography, CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, Computerized Tomography (CT) scan, CT, CT Scan, tomography, Echocardiography, EC, Magnetic Resonance Imaging, Magnetic Resonance, Magnetic Resonance Imaging (MRI), Magnetic resonance imaging (procedure), Magnetic Resonance Imaging Scan, Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance, MR, MR Imaging, MRI, MRI Scan, MRIs, NMR Imaging, NMRI, Nuclear Magnetic Resonance Imaging, sMRI, Structural MRI, Nirogacestat, (S)-2-(((S)-6,8-Difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)amino)-N-(1-(2-methyl-1-(neopentylamino)propan-2-yl)-1H-imidazol-4-yl)pentanamide, PF-03084014, Quality-of-Life Assessment, Quality of Life Assessment, Questionnaire Administration, X-Ray Imaging, Conventional X-Ray, Diagnostic Radiology, Medical Imaging, X-Ray, Plain film radiographs, Radiographic Imaging, Radiographic imaging procedure (procedure), Radiography, RG, Static X-Ray, X-Ray
Children's Oncology Group, National Cancer Institute (NCI), SpringWorks Therapeutics, Inc.
Desmoid Fibromatosis, Recurrent Desmoid Fibromatosis, Unresectable Desmoid Fibromatosis
12/24
12/24
NCT04751409: Evaluating the Impact of Limited Compared With Intense Post-Operative Surveillance on Patient-Reported Outcomes in Patients With Stage II-III Soft Tissue Sarcoma of the Trunk and Extremities

Recruiting
2
227
US
Chest Radiography, Chest X-ray, Computed Tomography, CAT, CAT Scan, Computerized Axial Tomography, Computerized Tomography, CT, CT Scan, tomography, Follow-Up, Active Follow-up, Clinical Signs Follow-up, CLSFUP, Follow Up, follow_up, Followed, Followup, Imaging Technique, Diagnostic Imaging Technique, Imaging, imaging procedure, Imaging Procedures, Imaging, Not Otherwise Specified, Medical Imaging, Questionnaire Administration
M.D. Anderson Cancer Center
Stage II Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8, Stage III Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8, Stage IIIA Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8, Stage IIIB Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8
12/24
12/24
ChiCTR2100049157: Doxorubicin (A) Plus Camrelizumab (C) Versus Doxorubicin Alone for the First-Line Treatment (T) of Select Type of Adcanced Soft Tissue Sarcoma (ACTS): A Randomised Controlled Multi Centers Trial

Not yet recruiting
2
124
 
Camrelizumab Plus Doxorubicin ;Doxorubicin
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology; Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiangsu Hengrui Pharma
Soft Tissue Sarcoma
 
 
NCT05224934: Preoperative Ultra-hypofractionated Radiotherapy Followed by Surgery for Retroperitoneal Sarcoma

Recruiting
2
28
RoW
ultra-hypofractionated radiotherapy
Chinese Academy of Medical Sciences
Soft Tissue Sarcoma, Retroperitoneal Sarcoma, Radiotherapy Side Effect, Ultra-hypofractionated Radiotherapy, Stereotactic Ablative Radiotherapy
12/24
12/24
RAFAS-001, ChiCTR2300071863: A Phase II Clinical Trial Evaluating the Safety and Efficacy of Radioactive Particle and Fluzoparib Combination Therapy in the Treatment of Advanced Unresectable Soft Tissue Sarcoma

Not yet recruiting
2
32
 
Fluzoparib 150 mg Bid was given orally after meals for 2 months (60 days) in a continuous cycle 48 h after radioactive particle implantation
Sun Yat-sen University Cancer Center; Sun Yat-sen University Cancer Center, The fluzoparib is provided by the Jiangsu Hengrui Pharmaceuticals Co., Ltd.
Soft tissue sarcoma.
 
 
NCI-2021-12582, NCT05174455: Niraparib for the Treatment of Leiomyosarcoma

Withdrawn
2
22
NA
Niraparib Tosylate Monohydrate, Zejula
David Liebner, MD
Locally Advanced Leiomyosarcoma, Metastatic Leiomyosarcoma, Stage III Retroperitoneal Sarcoma AJCC v8, Stage IIIA Retroperitoneal Sarcoma AJCC v8, Stage IIIB Retroperitoneal Sarcoma AJCC v8, Stage IV Retroperitoneal Sarcoma AJCC v8, Unresectable Leiomyosarcoma
12/24
12/25
BFR-ESS, NCT03624244: Evaluation of Clinical Impact of Interruption VS Maintenance of AI in Patients With Locally Advanced/ Metastatic Low Grade Endometrial Stromal Sarcoma (LGESS)

Recruiting
2
40
Europe
Aromatase Inhibitors, ANASTRAZOLE, ARIMIDEX, AROMASINE, EXEMESTANE, FEMARA, LETROZOLE
Centre Leon Berard
Low Grade Endometrial Stromal Sarcoma
01/25
01/28
CRESTONE, NCT04383210: Study of Seribantumab in Adult Patients With NRG1 Gene Fusion Positive Advanced Solid Tumors

Active, not recruiting
2
75
Canada, US, RoW
Seribantumab
Elevation Oncology
Locally Advanced Solid Tumor, Metastatic Solid Tumor, Pancreatic Cancer, Lung Cancer, Head and Neck Cancer, Breast Cancer, Kidney Cancer, Colorectal Cancer, Bladder Cancer, Ovarian Cancer, Sarcoma, Gallbladder Cancer, Bile Duct Cancer, Esophageal Cancer, Uterine Cancer, Cholangiocarcinoma, Prostate Cancer
01/25
03/25
GIST-TEN, NCT05009927: Efficiency of Imatinib Treatment After 10 Years of Treatment in Patients With Gastrointestinal Stromal Tumours (GIST) (Gist-Ten)

Recruiting
2
50
Europe
Imatinib tablets, Glivec
Centre Leon Berard
Metastatic Gastrointestinal Stromal Tumor (GIST), C-KIT Mutation, Advanced Gastrointestinal Stromal Tumor (GIST)
01/25
01/27
ATEZOGIST, NCT05152472: A Prospective, Randomized, Multicenter, Comparative Study of the Efficacy of Imatinib Resumption Combined With Atezolizumab Versus Imatinib Resumption Alone in Patients With Unresectable Advanced Gastrointestinal Stromal Tumors (GIST) After Failure of Standard Treatments

Recruiting
2
110
Europe
Atezolizumab 1200 mg, Tecentriq®, Imatinib 400 MG, Glivec®
Centre Leon Berard
Unresectable Gastrointestinal Stromal Tumor (GIST), Locally Advanced Gastrointestinal Stromal Tumor (GIST), Metastatic Gastrointestinal Stromal Tumor
01/25
06/26
NCT05941325: A Single-arm, Open-label, Single-center Prospective Study of Fruquintinib Combined With Envafolimab in the Treatment of Advanced or Unresectable Locally Advanced Bone and Soft Tissue Sarcoma

Recruiting
2
20
RoW
fruquintinib, Envafolimab
Shanghai 6th People's Hospital
Advanced or Unresectable Locally Advanced Bone and Soft Tissue Sarcoma
12/25
12/26
PRACTISS, NCT06476704: Phase 2 Study of Preoperative RAdiation Therapy With Concomitant Liposomal Transcrocetin (L-TC) in Soft tISsue Sarcomas

Not yet recruiting
2
42
Europe
Administration of L-TC, HFRT alone
Institut de cancérologie Strasbourg Europe, LEAF4Life, Inc.
Sarcoma
12/30
12/30
NCT06388018: Tailoring Therapy in Post-surgical Patients With Low-risk Endometrial Cancer

Suspended
2
325
US
Clinical Observation, observation, Computed Tomography, CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, Computerized Tomography (CT) scan, CT, CT Scan, tomography, External Beam Radiation Therapy, Definitive Radiation Therapy, EBRT, External Beam Radiation, External Beam Radiotherapy, External Beam Radiotherapy (conventional), External Beam RT, external radiation, External Radiation Therapy, external-beam radiation, Radiation, External Beam, Teleradiotherapy, Teletherapy, Teletherapy Radiation, High-Dose-Rate Vaginal Brachytherapy, HDR-IVB, High-Dose-Rate Intra-Vaginal Brachytherapy, Magnetic Resonance Imaging, Magnetic Resonance, Magnetic Resonance Imaging (MRI), Magnetic resonance imaging (procedure), Magnetic Resonance Imaging Scan, Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance, MR, MR Imaging, MRI, MRI Scan, MRIs, NMR Imaging, NMRI, Nuclear Magnetic Resonance Imaging, sMRI, Structural MRI, Positron Emission Tomography, Medical Imaging, Positron Emission Tomography, PET, PET Scan, Positron emission tomography (procedure), Positron Emission Tomography Scan, Positron-Emission Tomography, proton magnetic resonance spectroscopic imaging, PT, Questionnaire Administration, X-Ray Imaging, Conventional X-Ray, Diagnostic Radiology, Medical Imaging, X-Ray, Plain film radiographs, Radiographic Imaging, Radiographic imaging procedure (procedure), Radiography, RG, Static X-Ray, X-Ray
NRG Oncology, National Cancer Institute (NCI), Canadian Cancer Trials Group
Stage I Uterine Corpus Endometrial Stromal Sarcoma AJCC v8, Stage II Uterine Corpus Endometrial Stromal Sarcoma AJCC v8, Stage III Uterine Corpus Endometrial Stromal Sarcoma AJCC v8
01/27
01/27
NCI-2018-02517, NCT03744793: Pemetrexed and Avelumab in Treating Patients With MTAP-Deficient Metastatic Urothelial Cancer

Active, not recruiting
2
18
US
Avelumab, Bavencio, MSB-0010718C, MSB0010718C, Pemetrexed, MTA, Multitargeted Antifolate
M.D. Anderson Cancer Center, National Cancer Institute (NCI)
Infiltrating Bladder Urothelial Carcinoma Sarcomatoid Variant, Infiltrating Bladder Urothelial Carcinoma With Glandular Differentiation, Infiltrating Bladder Urothelial Carcinoma With Squamous Differentiation, Infiltrating Bladder Urothelial Carcinoma, Micropapillary Variant, Infiltrating Bladder Urothelial Carcinoma, Plasmacytoid Variant, Metastatic Urothelial Carcinoma, MTAP Negative
01/25
01/25
NCT03601806: Pomalidomide in Treating Patients With Kaposi Sarcoma and Human Immunodeficiency Virus Infection

Active, not recruiting
2
26
RoW
Laboratory Biomarker Analysis, Pomalidomide, 4-Amino thalidomide, Actimid, CC-4047, Imnovid, Pomalyst
AIDS Malignancy Consortium, National Cancer Institute (NCI), The Emmes Company, LLC, University of Arkansas, Montefiore Medical Center, University of Stellenbosch, Weill Medical College of Cornell University, University of California, Los Angeles
Human Immunodeficiency Virus 1 Positive, Skin Kaposi Sarcoma
11/24
01/26
TOMAS2, NCT03838744 / 2018-004497-10: Randomized Trial in Advanced, Metastatic or Unresectable Soft Tissue Sarcoma After Failure of Standard Treatments.

Active, not recruiting
2
126
Europe
Standard arm: Trabectedin in monotherapy, Trabectedin arm, Experimental arm: Trabectedin + Olaparib, Trabectedin+ Olaparib arm
Italian Sarcoma Group, PharmaMar, AstraZeneca
Advanced Soft Tissue Sarcoma
02/25
02/25
NCT04771520: Avapritinib for the Treatment of CKIT or PDGFRA Mutation-Positive Locally Advanced or Metastatic Malignant Solid Tumors

Recruiting
2
50
US
Avapritinib, (S)-1-(4-fluorophenyl)-1-(2-(4-(6-(1-methyl-1Hpyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)piperazin-yl)pyrimidin-5-yl)ethan-1-amine, AYVAKIT, BLU-285, CS3007, PDGFR alpha/KIT Mutant-specific Inhibitor BLU-285
M.D. Anderson Cancer Center, National Cancer Institute (NCI)
Anatomic Stage IV Breast Cancer AJCC v8, Clinical Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8, Clinical Stage IVA Gastroesophageal Junction Adenocarcinoma AJCC v8, Clinical Stage IVB Gastroesophageal Junction Adenocarcinoma AJCC v8, Locally Advanced Malignant Solid Neoplasm, Locally Advanced Melanoma, Locally Advanced Primary Malignant Central Nervous System Neoplasm, Locally Advanced Sarcoma, Metastatic Malignant Solid Neoplasm, Metastatic Melanoma, Metastatic Primary Malignant Central Nervous System Neoplasm, Metastatic Sarcoma, Pathologic Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8, Pathologic Stage IVA Gastroesophageal Junction Adenocarcinoma AJCC v8, Pathologic Stage IVB Gastroesophageal Junction Adenocarcinoma AJCC v8, Postneoadjuvant Therapy Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8, Postneoadjuvant Therapy Stage IVA Gastroesophageal Junction Adenocarcinoma AJCC v8, Postneoadjuvant Therapy Stage IVB Gastroesophageal Junction Adenocarcinoma AJCC v8, Prognostic Stage IIIC Breast Cancer AJCC v8, Prognostic Stage IV Breast Cancer AJCC v8, Stage IIIC Colorectal Cancer AJCC v8, Stage IIIC Lung Cancer AJCC v8, Stage IV Colorectal Cancer AJCC v8, Stage IV Lung Cancer AJCC v8, Stage IVA Colorectal Cancer AJCC v8, Stage IVA Lung Cancer AJCC v8, Stage IVB Colorectal Cancer AJCC v8, Stage IVB Lung Cancer AJCC v8, Stage IVC Colorectal Cancer AJCC v8
02/25
02/25
TORNADO, NCT04968106: Neoadjuvant Chemotherapy and Retifanlimab in Patients With Selected Sarcomas

Recruiting
2
66
Europe
Doxorubicin, Ifosfamide, INCMGA00012, Retifanlimab
Institut Bergonié, Incyte Biosciences International Sàrl
Resectable Sarcoma
03/25
10/27
NCT05580588: Open-Label Study of the CDK4/6 Inhibitor SPH4336 in Subjects With Locally Advanced or Metastatic Liposarcomas

Recruiting
2
33
US
SPH4336
Shanghai Pharma Biotherapeutics USA Inc.
Liposarcoma, Dedifferentiated
03/25
03/25
NCT05193188: A Study of Anlotinib Combined With or Without PD-1 Antibody on Unresectable High-grade Chondrosarcoma

Recruiting
2
70
RoW
Anlotinib hydrochloride, FuKeWei, PD-1 inhibitor
Second Affiliated Hospital, School of Medicine, Zhejiang University
Chondrosarcoma
03/25
03/26
SCOPES, NCT04425967: Short Course Of Preoperative Radiotherapy in Head and Neck-, Trunk- and Extremity Soft Tissue Sarcomas

Recruiting
2
163
Europe
pre-operative radiotherapy, radiotherapy
The Netherlands Cancer Institute, Leiden University Medical Center
Soft Tissue Sarcomas
04/25
04/34
TORAN, ChiCTR2100054901: A phase II trial of anlotinib and toripalimab as maintenance therapy in patients with advanced soft tissue sarcoma after anthracycline-based chemotherapy

Recruiting
2
50
China
Anlotinib + Toripalimab
West China Hospital, Sichuan University ; West China Hospital, Sichuan University, West China Hospital, Sichuan University; Shanghai Junshi Biosciences Co., Ltd.; Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Soft tissue sarcoma
 
 
ChiCTR2200058469: Preoperative Ultra-hypofractionated Radiotherapy Followed by Surgery for Retroperitoneal Sarcoma

Recruiting
2
28
 
ultra-hypofractionated radiotherapy
Cancer Institute and Hospital, Chinese Academy of Medical Sciences; Cancer Institute and Hospital, Chinese Academy of Medical Sciences, No
soft tissue sarcoma
 
 
REFIT-MSS, NCT05582031: Regorafenib With Tislelizumab in Patients With Selected Mismatch Repair-Proficient/Microsatellite Stable Cancers

Withdrawn
2
322
NA
Regorafenib in combination with Tislelizumab
Translational Research in Oncology, Bayer, Novartis
Anal Squamous Cell Carcinoma, Colorectal Neoplasms, Soft Tissue Sarcoma, Malignant Pleural Mesothelioma, Small Cell Lung Carcinoma, Castrate Resistant Prostate Cancer, Neuroendocrine Carcinoma of Prostate, Gastroenteropancreatic Neuroendocrine Neoplasm
04/25
04/25
NCT05333458: Testing Atezolizumab With or Without Selinexor in Patients >= 18 Years Old With Alveolar Soft Part Sarcoma, the Axiom Study

Recruiting
2
77
US
Atezolizumab, MPDL 3280A, MPDL 328OA, MPDL-3280A, MPDL3280A, MPDL328OA, RG7446, RO5541267, Tecentriq, Biopsy, BIOPSY_TYPE, Bx, Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Computed Tomography, CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, Computerized Tomography (CT) scan, CT, CT Scan, tomography, Magnetic Resonance Imaging, Magnetic Resonance, Magnetic Resonance Imaging (MRI), Magnetic resonance imaging (procedure), Magnetic Resonance Imaging Scan, Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance, MR, MR Imaging, MRI, MRI Scan, MRIs, NMR Imaging, NMRI, Nuclear Magnetic Resonance Imaging, sMRI, Structural MRI, Selinexor, ATG-010, CRM1 Nuclear Export Inhibitor KPT-330, KPT-330, Nexpovio, Selective Inhibitor of Nuclear Export KPT-330, SINE KPT-330, Xpovio
National Cancer Institute (NCI)
Advanced Alveolar Soft Part Sarcoma, Advanced Soft Tissue Sarcoma, Metastatic Alveolar Soft Part Sarcoma, Unresectable Alveolar Soft Part Sarcoma
05/25
05/25
NCT04530487: Donor Stem Cell Transplant After Chemotherapy for the Treatment of Recurrent or Refractory High-Risk Solid Tumors in Pediatric and Adolescent-Young Adults

Recruiting
2
40
US
Allogeneic Hematopoietic Stem Cell Transplantation, Allogeneic Hematopoietic Cell Transplantation, Allogeneic Stem Cell Transplantation, HSC, HSCT, Stem Cell Transplantation, Allogeneic, Cyclosporine, 27-400, Ciclosporin, CsA, Cyclosporin, Cyclosporin A, Cyclosporine Modified, Gengraf, Neoral, OL 27-400, Sandimmune, SangCya, Etoposide, Demethyl Epipodophyllotoxin Ethylidine Glucoside, EPEG, Lastet, Toposar, Vepesid, VP 16, VP 16-213, VP-16, VP-16-213, VP16, Fludarabine Phosphate, 2-F-ara-AMP, 9H-Purin-6-amine, 2-fluoro-9-(5-O-phosphono-.beta.-D-arabinofuranosyl)-, Beneflur, Fludara, SH T 586, Lapine T-Lymphocyte Immune Globulin, Anti-Thymocyte Globulin Rabbit, Grafalon, Rabbit Anti-Human Thymocyte Globulin (RATG), Rabbit Anti-Thymocyte Globulin, Rabbit Antithymocyte Globulin, Rabbit ATG, rATG, Thymoglobulin, Melphalan, Alanine Nitrogen Mustard, CB-3025, L-PAM, L-Phenylalanine Mustard, L-Sarcolysin, L-Sarcolysin Phenylalanine mustard, L-Sarcolysine, Melphalanum, Phenylalanine Mustard, Phenylalanine Nitrogen Mustard, Sarcoclorin, Sarkolysin, WR-19813, Mycophenolate Mofetil, CellCept, MMF, Tacrolimus, FK 506, Fujimycin, Hecoria, Prograf, Protopic, Thiotepa, 1,1'',1''''-Phosphinothioylidynetrisaziridine, Girostan, N,N'', N''''-Triethylenethiophosphoramide, Oncotiotepa, STEPA, Tepadina, TESPA, Tespamin, Tespamine, Thio-Tepa, Thiofosfamide, Thiofozil, Thiophosphamide, Thiophosphoramide, Thiotef, Tifosyl, TIO TEF, Tio-tef, Triethylene Thiophosphoramide, Triethylenethiophosphoramide, Tris(1-aziridinyl)phosphine sulfide, TSPA, WR 45312
M.D. Anderson Cancer Center
Desmoplastic Small Round Cell Tumor, Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor, Recurrent Desmoplastic Small Round Cell Tumor, Recurrent Malignant Peripheral Nerve Sheath Tumor, Recurrent Malignant Solid Neoplasm, Recurrent Neuroblastoma, Recurrent Rhabdomyosarcoma, Refractory Desmoplastic Small Round Cell Tumor, Refractory Malignant Peripheral Nerve Sheath Tumor, Refractory Malignant Solid Neoplasm, Refractory Neuroblastoma, Refractory Rhabdomyosarcoma
05/25
05/25
NCT04305691: Trial of Ixazomib for Kaposi Sarcoma

Recruiting
2
41
US
Ixazomib Citrate, MLN-9708, MLN9708, Ninlaro, Quality-of-Life Assessment, Quality of Life Assessment, Questionnaire Administration
AIDS Malignancy Consortium, National Cancer Institute (NCI)
Kaposi Sarcoma, Skin
05/25
05/26
NCT04438824: Palbociclib and INCMGA00012 in People With Advanced Liposarcoma

Active, not recruiting
2
42
US
INCMGA00012, Palbociclib
Memorial Sloan Kettering Cancer Center, Incyte Corporation
Well-differentiated/Dedifferentiated Liposarcoma
06/25
06/25
ChiCTR2300072293: An exploratory study on the first-line treatment of advanced unresectable soft tissue sarcoma with zimberelimab administered in combination with anlotinib and eribulin

Recruiting
2
30
 
zimberelimab administered in combination with anlotinib and eribulin
Sanhuan Cancer Hospital, Chaoyang District, Beijing; Sanhuan Cancer Hospital, selt-funded
soft tissue sarcoma
 
 
RMS13, NCT01871766: Risk-Adapted Focal Proton Beam Radiation and/or Surgery in Patients With Low, Intermediate and High Risk Rhabdomyosarcoma Receiving Standard or Intensified Chemotherapy

Active, not recruiting
2
98
US
Vincristine, Oncovin®, Dactinomycin, Actinomycin-D, Cosmegen®, Cyclophosphamide, Cytoxan(R), Surgical Resection, Surgery, Radiation, Proton Beam Radiation, External Beam Radiation, Brachytherapy, Bevacizumab, rhuMab, VEGF, Avastin®, Sorafenib, Nexavar®, Myeloid Growth Factor, G-CSF, Filgrastim, Pegfilgrastim, Lymph Node Sampling, Irinotecan, Camptosar ®, Ifosfamide, Ifex ®, Etoposide, VP-16, Vepesid®, Etoposide Phosphate, Etopophos®, Doxorubicin, Adriamycin®, Dexrazoxane, Zinecard, ^1^1C-methionine, Contrast Media
St. Jude Children's Research Hospital
Rhabdomyosarcoma
07/25
06/30
NCT02502786: Humanized Monoclonal Antibody 3F8 (Hu3F8) With Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) in the Treatment of Recurrent Osteosarcoma

Active, not recruiting
2
46
US
humanized anti-GD2 antibody, hu3F8, GM-CSF
Memorial Sloan Kettering Cancer Center, Children's Hospital Los Angeles, M.D. Anderson Cancer Center, Y-mAbs Therapeutics
Recurrent Osteosarcoma
07/25
07/25
BRAF, NCT03973918: Study of Binimetinib With Encorafenib in Adults With Recurrent V600-Mutated HGG

Terminated
2
5
US
Encorafenib, Braftovi, Binimetinib, Mektovi, Research Bloods, Circulating Tumor DNA, Tumor Tissue
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, National Cancer Institute (NCI), Pfizer
High Grade Glioma, BRAF V600E, BRAF V600K, Anaplastic Astrocytoma, Anaplastic Pleomorphic Xanthoastrocytoma, Gliosarcoma, Glioblastoma
04/22
10/23
Stereosarc, NCT03548428: Stereotaxic Body Irradiation of Oligometastase in Sarcoma

Recruiting
2
103
Europe
Atezolizumab, SBRT, High Dose Radiation
Centre Antoine Lacassagne, Centre Hospitalier Universitaire de Caen, Roche Pharma AG
Sarcoma, Radiosurgery
07/25
12/27
NCT05302921: Neoadjuvant Dual Checkpoint Inhibition and Cryoablation in Relapsed/Refractory Pediatric Solid Tumors

Active, not recruiting
2
5
US
Cryoablation Therapy, Cryosurgery, Cryotherapy, Cryoablation, Nivolumab, Ipilimumab
Children's National Research Institute, Bristol-Myers Squibb
Osteosarcoma, Ewing Sarcoma, Rhabdomyosarcoma, Relapsed Pediatric Solid Tumor, Refractory Pediatric Solid Tumor, Melanoma, Hepatoblastoma, Hepatocellular Carcinoma, Neuroblastoma, Wilms Tumor
07/25
07/25
NCT05926492: A Clinical Study of Surufatinib Combined With Chemotherapy as Neoadjuvant Treatment in Osteosarcoma

Recruiting
2
160
RoW
Surufatinib plus chemotherapy, Arm A, Chemotherapy, Arm B
Second Affiliated Hospital, School of Medicine, Zhejiang University
Osteosarcoma
07/25
07/26
NAVIGATE, NCT02576431 / 2015-003582-28: A Study to Test the Effect of the Drug Larotrectinib in Adults and Children With NTRK-fusion Positive Solid Tumors

Checkmark Approved for adult & pediatric patients with advanced solid tumors that harbor a NTRK gene fusion
Apr 2022 - Apr 2022: Approved for adult & pediatric patients with advanced solid tumors that harbor a NTRK gene fusion
Checkmark For locally advanced/metastatic TRK fusion thyroid cancer & metastatic lung cancer
Sep 2020 - Sep 2020: For locally advanced/metastatic TRK fusion thyroid cancer & metastatic lung cancer
Checkmark Data of patients with TRK fusion thyroid cancer [NAVIGATE]
More
Active, not recruiting
2
215
Europe, Japan, US, RoW
BAY2757556 (Larotrectinib, Vitrakvi), LOXO-101
Bayer
Solid Tumors Harboring NTRK Fusion
07/25
10/25
ChiCTR2200062161: Safety and Efficacy of Utidelone in Patients with Refractory Advanced Soft-Tissue Sarcoma: A Prospective Single-arm Phase II Study

Not yet recruiting
2
27
 
Utidelone treatment
West China Hospital, Sichuan University; West China Hospital, Sichuan University, No
Soft-Tissue Sarcoma
 
 
CABOSUN II, NCT03541902: Cabozantinib or Sunitinib Malate in Treating Participants With Metastatic Variant Histology Renal Cell Carcinoma

Checkmark Results from CABOSUN study
Oct 2018 - Oct 2018: Results from CABOSUN study
Active, not recruiting
2
32
US
Cabozantinib, Sunitinib Malate, SU011248, SU11248, sunitinib, Sutent
M.D. Anderson Cancer Center, Exelixis, National Cancer Institute (NCI)
Malignant Neoplasms of Urinary Tract, Renal Cell Carcinoma, Chromophobe Renal Cell Carcinoma, Metastatic Renal Cell Carcinoma, Papillary Renal Cell Carcinoma, Renal Cell Carcinoma Associated With Xp11.2 Translocations/TFE3 Gene Fusions, Sarcomatoid Renal Cell Carcinoma, Stage IV Renal Cell Cancer AJCC v8, Unclassified Renal Cell Carcinoma
07/25
07/25
NCT00592592: Proton RT for the Treatment of Pediatric Rhabdomyosarcoma

Recruiting
2
110
US
Proton Beam Radiation
Massachusetts General Hospital, M.D. Anderson Cancer Center, Brigham and Women's Hospital, Boston Children's Hospital, Dana-Farber Cancer Institute, National Institutes of Health (NIH), National Cancer Institute (NCI)
Rhabdomyosarcoma
08/25
08/25
 

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