Sarcoma
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1664 Trials

   

 
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Sarcoma
NCT02713269: Thermal Ablation and Spine Stereotactic Radiosurgery in Treating Patients With Spine Metastases at Risk for Compressing the Spinal Cord

Completed
2
60
US
Computed Tomography, CAT, CAT Scan, Computerized Axial Tomography, computerized tomography, CT, CT SCAN, tomography, Quality-of-Life Assessment, Quality of Life Assessment, Questionnaire Administration, Stereotactic Radiosurgery, Stereotactic External Beam Irradiation, stereotactic external-beam radiation therapy, stereotactic radiation therapy, Stereotactic Radiotherapy, stereotaxic radiation therapy, stereotaxic radiosurgery, Thermal Ablation Therapy, thermal ablation
M.D. Anderson Cancer Center, National Cancer Institute (NCI)
Malignant Digestive System Neoplasm, Metastatic Head and Neck Carcinoma, Metastatic Kidney Carcinoma, Metastatic Malignant Neoplasm in the Spine, Metastatic Malignant Neoplasm of Unknown Primary, Metastatic Melanoma, Prostate Carcinoma Metastatic in the Bone, Sarcoma, Solid Neoplasm, Spinal Cord Compression, Stage IV Breast Cancer AJCC v6 and v7, Stage IV Lung Non-Small Cell Cancer AJCC v7, Thyroid Gland Carcinoma
09/23
09/23
NCT03213678: Samotolisib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With TSC or PI3K/MTOR Mutations (A Pediatric MATCH Treatment Trial)

Active, not recruiting
2
18
US
Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Computed Tomography, CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, Computerized Tomography (CT) scan, CT, CT Scan, tomography, FDG-Positron Emission Tomography, FDG, FDG-PET, FDG-PET Imaging, Magnetic Resonance Imaging, Magnetic Resonance, Magnetic Resonance Imaging (MRI), Magnetic resonance imaging (procedure), Magnetic Resonance Imaging Scan, Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance, MR, MR Imaging, MRI, MRI Scan, MRIs, NMR Imaging, NMRI, Nuclear Magnetic Resonance Imaging, sMRI, Structural MRI, Samotolisib, 2H-Imidazo(4,5-C)quinolin-2-one, 1,3-Dihydro-8-(5-(1-hydroxy-1-methylethyl)-3-pyridinyl)-1-((2S)-2-methoxypropyl)-3-methyl-, LY 3023414, LY-3023414, LY3023414, WHO 10889, X-Ray Imaging, Conventional X-Ray, Diagnostic Radiology, Medical Imaging, X-Ray, Plain film radiographs, Radiographic Imaging, Radiographic imaging procedure (procedure), Radiography, RG, Static X-Ray, X-Ray
National Cancer Institute (NCI)
Advanced Malignant Solid Neoplasm, Ann Arbor Stage III Non-Hodgkin Lymphoma, Ann Arbor Stage IV Non-Hodgkin Lymphoma, Malignant Glioma, Recurrent Ependymoma, Recurrent Ewing Sarcoma, Recurrent Glioma, Recurrent Hepatoblastoma, Recurrent Langerhans Cell Histiocytosis, Recurrent Malignant Germ Cell Tumor, Recurrent Malignant Solid Neoplasm, Recurrent Medulloblastoma, Recurrent Neuroblastoma, Recurrent Non-Hodgkin Lymphoma, Recurrent Osteosarcoma, Recurrent Peripheral Primitive Neuroectodermal Tumor, Recurrent Primary Central Nervous System Neoplasm, Recurrent Rhabdomyosarcoma, Recurrent Soft Tissue Sarcoma, Refractory Langerhans Cell Histiocytosis, Refractory Malignant Germ Cell Tumor, Refractory Malignant Solid Neoplasm, Refractory Neuroblastoma, Refractory Non-Hodgkin Lymphoma, Refractory Primary Central Nervous System Neoplasm, Rhabdoid Tumor, Stage III Osteosarcoma AJCC v7, Stage III Soft Tissue Sarcoma AJCC v7, Stage IV Osteosarcoma AJCC v7, Stage IV Soft Tissue Sarcoma AJCC v7, Stage IVA Osteosarcoma AJCC v7, Stage IVB Osteosarcoma AJCC v7, Wilms Tumor
09/23
10/24
NCT03210714 / 2021-005604-35: Erdafitinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With FGFR Mutations (A Pediatric MATCH Treatment Trial)

Active, not recruiting
2
20
US
Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Bone Marrow Aspiration and Biopsy, Bone Scan, Bone Scintigraphy, Computed Tomography, CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, Computerized Tomography (CT) scan, CT, CT Scan, tomography, Erdafitinib, Balversa, JNJ-42756493, Laboratory Biomarker Analysis, Magnetic Resonance Imaging, Magnetic Resonance, Magnetic Resonance Imaging (MRI), Magnetic resonance imaging (procedure), Magnetic Resonance Imaging Scan, Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance, MR, MR Imaging, MRI, MRI Scan, MRIs, NMR Imaging, NMRI, Nuclear Magnetic Resonance Imaging, sMRI, Structural MRI, Pharmacological Study, Positron Emission Tomography, Medical Imaging, Positron Emission Tomography, PET, PET Scan, Positron emission tomography (procedure), Positron Emission Tomography Scan, Positron-Emission Tomography, proton magnetic resonance spectroscopic imaging, PT, Radionuclide Imaging, NM, Nuclear Medicine, nuclear medicine scan, radioimaging, Radionuclide Scanning, Scan, Scintigraphy, X-Ray Imaging, Conventional X-Ray, Diagnostic Radiology, Medical Imaging, X-Ray, Plain film radiographs, Radiographic Imaging, Radiographic imaging procedure (procedure), Radiography, RG, Static X-Ray, X-Ray
National Cancer Institute (NCI)
Advanced Malignant Solid Neoplasm, Recurrent Childhood Ependymoma, Recurrent Childhood Malignant Germ Cell Tumor, Recurrent Childhood Medulloblastoma, Recurrent Childhood Non-Hodgkin Lymphoma, Recurrent Childhood Osteosarcoma, Recurrent Childhood Rhabdomyosarcoma, Recurrent Childhood Soft Tissue Sarcoma, Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor, Recurrent Hepatoblastoma, Recurrent Langerhans Cell Histiocytosis, Recurrent Malignant Glioma, Recurrent Malignant Solid Neoplasm, Recurrent Neuroblastoma, Recurrent Primary Central Nervous System Neoplasm, Recurrent Rhabdoid Tumor, Refractory Childhood Malignant Germ Cell Tumor, Refractory Childhood Osteosarcoma, Refractory Childhood Rhabdomyosarcoma, Refractory Childhood Soft Tissue Sarcoma, Refractory Ependymoma, Refractory Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor, Refractory Hepatoblastoma, Refractory Langerhans Cell Histiocytosis, Refractory Malignant Glioma, Refractory Malignant Solid Neoplasm, Refractory Medulloblastoma, Refractory Neuroblastoma, Refractory Non-Hodgkin Lymphoma, Refractory Primary Central Nervous System Neoplasm, Refractory Rhabdoid Tumor, Wilms Tumor
09/23
10/24
ChiCTR2000036605: Prospective clinical study on targeted induction of antiangiogenic drugs for local advanced head and neck sarcoma

Not yet recruiting
2
61
 
Antinib hydrochloride capsule
Shanghai Ninth People's Hospital; Shanghai Ninth People's Hospital, Self finance
Head neck sarcoma
 
 
ChiCTR2200063703: Elemene combined with imatinib in the treatment of first-line therapy failure gastrointestinal stromal tumors: a single-arm, open phase II trial

Not yet recruiting
2
75
 
elemene combined with imatinib
Sun Yat-sen University Cancer Center; Sun Yat-sen University Cancer Center, Sponsored by Dalian Holley Jingang Pharmaceutical Co., Ltd.
Gastrointestinal stromal tumors
 
 
NCT01863745: Nilotinib Roll-over Protocol for Patients in Novartis-sponsored Nilotinib Study and Benefiting From Nilotinib Treatment

Completed
2
15
Japan
nilotinib
Novartis Pharmaceuticals
Gastrointestinal Stromal Tumors
10/23
10/23
NCT05864534: Phase 2a Immune Modulation With Ultrasound for Newly Diagnosed Glioblastoma

Recruiting
2
25
US
Balstilimab, BAL, Botensilimab, BOT, Liposomal Doxorubicin, DOX, Sonocloud-9 (SC-9), SC-9
Northwestern University, Agenus Inc., CarThera
Newly Diagnosed Glioblastoma, Glioblastoma, Isocitric Dehydrogenase (IDH)-Wildtype, Gliosarcoma, Glioblastoma Multiforme
05/26
08/26
MANTRA-2, NCT05012397: Milademetan in Advanced/Metastatic Solid Tumors

Terminated
2
40
US
RAIN-32, Milademetan
Rain Oncology Inc
Solid Tumors, Head and Neck Carcinoma, Cholangiocarcinoma, Sarcoma, Lung Adenocarcinoma, Bladder Urothelial Carcinoma, Stomach Adenocarcinoma, Breast Cancer Invasive, Ovarian Carcinoma, Cervical Cancer, Non Small Cell Lung Cancer, Gastric Cancer, Biliary Tract Cancer, Melanoma, Pancreas Cancer, MDM2 Gene Amplification, Testicular Germ Cell Tumor, Adrenocortical Carcinoma
10/23
10/23
NCT04518124: Propranolol in Angiosarcoma

Completed
2
14
Europe
Propranolol
The Netherlands Cancer Institute, Anticancer Fund, Belgium
Angiosarcoma
10/23
10/23
NCT04183062: BIO-11006 for Osteosarcoma and Ewing's Sarcoma Lung Metastases

Active, not recruiting
2
10
US
Chemotherapy (gemcitabine & docetaxel) plus BIO-11006
Nicklaus Children's Hospital f/k/a Miami Children's Hospital
Osteosarcoma Metastatic, Ewing's Sarcoma Metastatic
11/23
11/24
PROACH, NCT03742193: Pulmonary Resectable Metastases of Osteosarcoma With Anti-angiogenics and CHemotherapy

Active, not recruiting
2
43
RoW
Apatinib, VEGFR Inhibitor, GD regimen, Chemotherapy
Ruijin Hospital
Osteosarcoma, Pulmonary Metastases, Apatinib
11/23
12/23
NCT04028063: Doxorubicin Plus Dual Checkpoint Blockade for Soft Tissue Sarcomas

Recruiting
2
28
US
doxorubicin with AGEN1884 and AGEN2034
University of Colorado, Denver, Agenus Inc.
Metastatic Soft Tissue Sarcoma, Advanced Soft Tissue Sarcoma
11/24
11/25
NCT03944304: Paclitaxel in Patients With GIST With Low P-glycoprotein Expression After Failure of at Least Imatinib and Sunitinib, and Regorafenib.

Recruiting
2
40
RoW
Paclitaxel
Asan Medical Center
Gastrointestinal Stromal Tumors
11/25
11/25
NCT05138146: A Phase 2 Clinical Study of Evaluation of Recombinant Anti-PD-1 Humanized Monoclonal Antibody Injection (609A) Combined With Doxorubicin Hydrochloride in the Treatment of Metastatic/Unresectable Non-specific Soft Tissue Sarcoma

Not yet recruiting
2
70
RoW
609A, doxorubicin hydrochloride
Sunshine Guojian Pharmaceutical (Shanghai) Co., Ltd.
Sarcoma, Soft Tissue
11/23
12/24
NCT01898416: Safety and Efficacy Study Using 5-ALA Oral Administration as an Adjuvant Therapy on the Rate of Local Tumor Recurrence in Patients Who Have Desmoids Tumors

Recruiting
2
140
RoW
5-AMINOLEVULINIC ACID (5-ALA), is a non fluorescent prodrug.
michal roll
The Aim of the Study is to Evaluate the Efficacy of Photodynamic Therapy as an, Adjuvant Therapy on the Clinical Outcome of Patients With Desmoid Tumors After, Surgical Resection
12/23
12/26
NCT02945800: Nab-Paclitaxel and Gemcitabine for Recurrent/Refractory Sarcoma

Active, not recruiting
2
59
US
nab-Paclitaxel, Abraxane, Gemcitabine, Gemzar
H. Lee Moffitt Cancer Center and Research Institute, National Pediatric Cancer Foundation
Osteosarcoma, Ewing Sarcoma, Rhabdomyosarcoma, Soft Tissue Sarcoma
01/24
12/24
NCT03114527: Phase II Trial of Ribociclib and Everolimus in Advanced Dedifferentiated Liposarcoma (DDL) and Leiomyosarcoma (LMS)

Active, not recruiting
2
48
US
Ribociclib, LEE011, Everolimus, RAD001, Afinitor
Fox Chase Cancer Center
Soft Tissue Sarcoma
06/24
12/24
DAPPER, NCT03851614: Basket Combination Study of Inhibitors of DNA Damage Response, Angiogenesis and Programmed Death Ligand 1 in Patients With Advanced Solid Tumors

Active, not recruiting
2
90
Canada
Durvalumab, Imfinzi, Olaparib, Lynparza, AZD2281, Cediranib, AZD2171
University Health Network, Toronto, AstraZeneca
Mismatch Repair Proficient Colorectal Cancer, Pancreatic Adenocarcinoma, Leiomyosarcoma
01/25
01/25
NCT02923778: Talimogene Laherparepvec and Radiation Therapy in Treating Patients With Newly Diagnosed Soft Tissue Sarcoma That Can Be Removed by Surgery

Active, not recruiting
2
40
Canada, US
Biopsy, BIOPSY_TYPE, Bx, Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Magnetic Resonance Imaging, Magnetic Resonance, Magnetic Resonance Imaging (MRI), Magnetic resonance imaging (procedure), Magnetic Resonance Imaging Scan, Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance, MR, MR Imaging, MRI, MRI Scan, MRIs, NMR Imaging, NMRI, Nuclear Magnetic Resonance Imaging, sMRI, Structural MRI, Radiation Therapy, Cancer Radiotherapy, Energy Type, ENERGY_TYPE, Irradiate, Irradiated, Irradiation, Radiation, Radiation Therapy, NOS, Radiotherapeutics, Radiotherapy, RT, Therapy, Radiation, Talimogene Laherparepvec, ICP34.5-, ICP47-deleted Herpes Simplex Virus 1 (HSV-1) Incorporating the Human GM-CSF Gene, Imlygic, JS1 34.5-hGMCSF 47- pA-, T-VEC
National Cancer Institute (NCI)
Leiomyosarcoma, Liposarcoma, Sarcoma G2, Sarcoma G3, Soft Tissue Sarcoma, Soft Tissue Sarcoma of the Trunk and Extremities, Stage I Soft Tissue Sarcoma AJCC v7, Stage II Soft Tissue Sarcoma AJCC v7, Undifferentiated Pleomorphic Sarcoma
12/24
12/24
NCT04200443: Cabozantinib and Temozolomide for the Treatment of Unresectable or Metastatic Leiomyosarcoma or Other Soft Tissue Sarcoma

Active, not recruiting
2
72
US
Cabozantinib, Quality-of-Life Assessment, Quality of Life Assessment, Questionnaire Administration, Temozolomide, CCRG-81045, Imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3, 4-dihydro-3-methyl-4-oxo-, M & B 39831, M and B 39831, Methazolastone, RP-46161, SCH 52365, Temcad, Temodal, Temodar, Temomedac, TMZ
City of Hope Medical Center, National Cancer Institute (NCI)
Metastatic Leiomyosarcoma, Metastatic Soft Tissue Sarcoma, Stage III Uterine Corpus Leiomyosarcoma AJCC v8, Stage IIIA Uterine Corpus Leiomyosarcoma AJCC v8, Stage IIIB Uterine Corpus Leiomyosarcoma AJCC v8, Stage IIIC Uterine Corpus Leiomyosarcoma AJCC v8, Stage IV Uterine Corpus Leiomyosarcoma AJCC v8, Stage IVA Uterine Corpus Leiomyosarcoma AJCC v8, Stage IVB Uterine Corpus Leiomyosarcoma AJCC v8, Unresectable Leiomyosarcoma, Unresectable Soft Tissue Sarcoma
06/24
06/24
FLASH, NCT04733183: Efficacy and Safety of L19TNF in Previously Treated Patients With Advanced Stage or Metastatic Soft-tissue Sarcoma

Recruiting
2
98
Europe
Dacarbazine, DTIC, onfekafusp alfa, L19TNF
Philogen S.p.A.
Soft Tissue Sarcoma
12/24
12/24
NCT04727242: CytoreductiveSurgery & HIPEC w/Gemcitabine+Chemotherapy w/Dacarbazine in Uterine Leiomyosarcoma

Recruiting
2
25
US
Gemcitabine, Gemzar, Infugem, difluorodeoxycytidine hydrochloride, Dacarbazine, Dimethyl (triazeno) imidazolecarboxamide, Dacarbazine - DTIC, Biocarbazine, Cytoreductive Surgery, Functional Assessment of Cancer Therapy (FACT) G questionnaire, Computed Tomography (CT) or Magnetic Resonance Imaging (MRI) Scan, Gadolinium
Kristen Ganjoo
LMS - Leiomyosarcoma, Uterine Leiomyosarcoma
01/25
01/25
NCT05106777: Surufatinib in Patients With Osteosarcoma and Soft Tissue Sarcoma

Recruiting
2
47
RoW
Surufatinib, HMPL-012
Sun Yat-sen University
Sarcoma
12/23
12/23
TTI-621-03, NCT04996004: A Study to Learn About the Study Medicine (Called Ontorpacept or TTI-621) Given Alone and in Combination With Doxorubicin in People With Leiomyosarcoma

Terminated
2
75
US
Ontorpacept (TTI-621), Ontorpacept / SIRPα-IgG1 Fc, Doxorubicin, Adriamycin
Pfizer
Leiomyosarcoma
12/23
12/23
ISG/OS-2, NCT01459484 / 2011-001659-36: ABCB1/P-glycoprotein Expression as Biologic Stratification Factor for Patients With Non Metastatic Osteosarcoma

Completed
2
225
Europe
Mifamurtide arm, Methotrexate, Cisplatinum, doxorubicin, ifosfamide, mifamurtide, 3 drugs arm, methotrexate, cisplatin, doxorubicine
Italian Sarcoma Group
Osteosarcoma
04/24
04/24
NCT03890068: Anlotinib Maintenance Treatment for Advanced Soft Tissue Sarcoma

Recruiting
2
48
RoW
Anlotinib Hydrochloride, Anlotinib
Sun Yat-sen University, Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Soft Tissue Sarcoma
12/23
05/24
NCT04025931: Chidamide Combined With Toripalimab in Sarcoma

Recruiting
2
74
RoW
chidamide and toripalimab
Sun Yat-sen University
Sarcoma
12/23
12/24
NCT04589754: Adriamycin and Ifosfamide Combined With Sintilimab

Recruiting
2
176
RoW
Sintilimab plus chemotherapy, Adriamycin-based chemotherapy
Sun Yat-sen University
Soft Tissue Sarcoma
12/25
07/26
NCT05189483: Albumin-bound Paclitaxel Plus Camrelizumab for Advanced Soft Tissue Sarcoma.

Recruiting
2
40
RoW
Albumin-Bound Paclitaxel, Camrelizumab
Henan Cancer Hospital
Soft Tissue Sarcoma
07/24
07/24
ALT GIST, NCT02365441 / ACTRN12614000950662: A Randomised Trial of Imatinib Alternating With Regorafenib Compared to Imatinib Alone for the First Line Treatment of Advanced Gastrointestinal Stromal Tumour (GIST)

Active, not recruiting
2
78
Europe, RoW
Regorafenib, imatinib, Glevec
Australasian Gastro-Intestinal Trials Group, European Organisation for Research and Treatment of Cancer - EORTC, Scandinavian Sarcoma Group
Gastrointestinal Stromal Tumour
12/23
12/23
PalboSarc, NCT03242382 / 2016-004039-19: Trial of Palbociclib in Second Line of Advanced Sarcomas With CDK4 Overexpression.

Recruiting
2
40
Europe
Palbociclib, Ibrance
Grupo Espanol de Investigacion en Sarcomas
Soft-tissue Sarcoma, Osteosarcoma, Chordoma
09/24
09/24
NCT03668340: AZD1775 in Women With Recurrent or Persistent Uterine Serous Carcinoma or Uterine Carcinosarcoma

Active, not recruiting
2
49
US
AZD1775
Dana-Farber Cancer Institute, AstraZeneca
Uterine Cancer
12/24
12/25
SOC-1882, NCT03886311: Talimogene Laherparepvec, Nivolumab and Trabectedin for Sarcoma

Recruiting
2
40
US
Talimogene Laherparepvec 100000000 PFU/1 ML Injection Suspension [IMLYGIC], TVEC, Imlygic, Nivolumab IV Soln 100 MG/10ML, Opdivo, Trabectedin 0.25 MG/1 VIAL Intravenous Powder for Solution, Yondelis
Sarcoma Oncology Research Center, LLC
Sarcoma
12/24
03/25
NCT04189783: Repeat or Single Quadratus Lumborum Block for the Reduction of Opioid Prescriptions After Surgery in Retroperitoneal Sarcoma Patients ("RESQU-SARC" Trial)

Active, not recruiting
2
113
US
Liposomal Bupivacaine, Bupivacaine Liposome Injectable Suspension, Exparel, Quadratus Lumborum Block, QL Block, Questionnaire Administration
M.D. Anderson Cancer Center, National Cancer Institute (NCI)
Retroperitoneal Sarcoma
12/24
12/24
ChiCTR2100055071: A single-arm phase II exploratory clinical study of sintilimab combined with anlotinib in the second-line application of unresectable or metastatic soft tissue sarcoma and osteosarcoma

Recruiting
2
40
 
sintilimab in combination with anlotinib
Shandong First Medical University Affiliated Cancer Hospital; Shandong First Medical University Affiliated Cancer Hospital, Part of self-raised, part of Chia Tai Tianqing Company and Innovent Biopharmaceutical (Suzhou) Co., Ltd.
Soft tissue sarcoma and osteosarcoma
 
 
NCT05193214: A Phase II Study for 609A in the Treatment of Advanced Undifferentiated Pleomorphic Sarcoma

Not yet recruiting
2
30
RoW
Recombinant anti-PD-1 humanized monoclonal antibody injection, 609A
Sunshine Guojian Pharmaceutical (Shanghai) Co., Ltd.
Sarcoma, Soft Tissue
12/23
12/24
NCT03414229: A Study of Epacadostat, an IDO1 Inhibitor, in Combination With Pembrolizumab in Patients With Metastatic and/or Locally Advanced Sarcoma

Active, not recruiting
2
30
US
Epacadostat, Pembrolizumab
Memorial Sloan Kettering Cancer Center, Incyte Corporation, Merck Sharp & Dohme LLC, M.D. Anderson Cancer Center
Sarcoma
01/25
01/25
NCI-2018-01509, NCT03610490: Autologous Tumor Infiltrating Lymphocytes MDA-TIL in Treating Patients With Recurrent or Refractory Ovarian Cancer, Colorectal Cancer, or Pancreatic Ductal Adenocarcinoma

Active, not recruiting
2
60
US
Autologous Tumor Infiltrating Lymphocytes MDA-TIL, MDA Autologous TILs, MDA Autologous Tumor Infiltrating Lymphocytes, MDA-TILs, Cyclophosphamide, (-)-Cyclophosphamide, 2H-1,3,2-Oxazaphosphorine, 2-[bis(2-chloroethyl)amino]tetrahydro-, 2-oxide, monohydrate, Carloxan, Ciclofosfamida, Ciclofosfamide, Cicloxal, Clafen, Claphene, CP monohydrate, CTX, CYCLO-cell, Cycloblastin, Cycloblastine, Cyclophospham, Cyclophosphamid monohydrate, Cyclophosphamide Monohydrate, Cyclophosphamidum, Cyclophosphan, Cyclophosphane, Cyclophosphanum, Cyclostin, Cyclostine, Cytophosphan, Cytophosphane, Cytoxan, Fosfaseron, Genoxal, Genuxal, Ledoxina, Mitoxan, Neosar, Revimmune, Syklofosfamid, WR- 138719, Fludarabine, Fluradosa, Interleukin-2, Epidermal Thymocyte Activating Factor, ETAF, IL-2, IL2, IL2 Protein, Interleukin 2, Interleukin 2 Precursor, Interleukin II, Lymphocyte Mitogenic Factor, Mitogenic Factor, Ro-236019, T Cell Growth Factor, T-Cell Growth Factor, TCGF, Thymocyte Stimulating Factor, TSF, Quality-of-Life Assessment, Quality of Life Assessment
M.D. Anderson Cancer Center, Bristol-Myers Squibb, Iovance Biotherapeutics, National Cancer Institute (NCI)
Malignant Solid Neoplasm, Metastatic Colorectal Adenocarcinoma, Metastatic Ovarian Carcinoma, Metastatic Pancreatic Ductal Adenocarcinoma, Platinum-Resistant Ovarian Carcinoma, Recurrent High Grade Ovarian Serous Adenocarcinoma, Recurrent Ovarian Carcinosarcoma, Refractory Colorectal Carcinoma, Stage IV Colorectal Cancer AJCC v8, Stage IVA Colorectal Cancer AJCC v8, Stage IVB Colorectal Cancer AJCC v8, Stage IVC Colorectal Cancer AJCC v8
01/25
01/25
ETCTN, NCT04340843: Testing the Combination of Belinostat and SGI-110 (Guadecitabine) or ASTX727 for the Treatment of Unresectable and Metastatic Conventional Chondrosarcoma

Active, not recruiting
2
32
US
Belinostat, Beleodaq, PXD 101, PXD101, Biopsy, BIOPSY_TYPE, Bx, Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Computed Tomography, CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, Computerized Tomography (CT) scan, CT, CT Scan, tomography, Decitabine and Cedazuridine, ASTX727, C-DEC, CDA Inhibitor E7727/Decitabine Combination Agent ASTX727, Cedazuridine/Decitabine Combination Agent ASTX727, Cedazuridine/Decitabine Tablet, DEC-C, Inqovi, Guadecitabine, DNMT inhibitor SGI-110, S110, SGI-110, Magnetic Resonance Imaging, Magnetic Resonance, Magnetic Resonance Imaging (MRI), Magnetic resonance imaging (procedure), Magnetic Resonance Imaging Scan, Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance, MR, MR Imaging, MRI, MRI Scan, MRIs, NMR Imaging, NMRI, Nuclear Magnetic Resonance Imaging, sMRI, Structural MRI
National Cancer Institute (NCI)
Locally Advanced Unresectable Primary Central Chondrosarcoma, Metastatic Primary Central Chondrosarcoma, Unresectable Primary Central Chondrosarcoma
01/25
01/25
NCT05156268: A Study of Pembrolizumab and Olaparib in People With Endometrial Cancer or Endometrial Carcinosarcoma

Active, not recruiting
2
26
US
Pembrolizumab, Olaparib
Memorial Sloan Kettering Cancer Center, Merck Sharp & Dohme LLC
Endometrial Carcinosarcoma
01/25
01/25
NCT03137888: Spectroscopic MRI-Guided Radiation Therapy Planning in Glioblastoma

Active, not recruiting
2
34
US
Dose-Escalated Radiation Therapy, RT, Radiation Therapy, Spectroscopic Magnetic Resonance Imaging, sMRI, MRSI, Magnetic Resonance Spectroscopic Imaging, Temozolomide, Methazolastone, Temcad, Temodal, Temodar, Temomedac, TMZ
Emory University, Johns Hopkins University, University of Miami, National Cancer Institute (NCI), National Institutes of Health (NIH)
Glioblastoma, Gliosarcoma
01/25
01/25
NCT03746080: Whole Brain Radiation Therapy With Standard Temozolomide Chemo-Radiotherapy and Plerixafor in Treating Patients With Glioblastoma

Active, not recruiting
2
21
US
Plerixafor, AMD 3100, JM-3100, Mozobil, SDZ SID 791, Temozolomide, CCRG-81045, Imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3, 4-dihydro-3-methyl-4-oxo-, M & B 39831, M and B 39831, Methazolastone, RP-46161, SCH 52365, Temcad, Temodal, Temodar, Temomedac, Whole-Brain Radiotherapy (WBRT), WBRT, whole-brain radiation therapy, whole-brain radiotherapy, Radiation Therapy, XRT, RT
Lawrence D Recht, Sanofi
Glioblastoma, Glioblastoma With Primitive Neuronal Component, Gliosarcoma, Malignant Glioma, Oligodendroglial Component Present
05/22
07/27
NCT04595747: Testing the Anti-cancer Drug, Rogaratinib (BAY 1163877), for Treatment of Advanced Sarcoma With Alteration in Fibroblast Growth Factor Receptor (FGFR 1-4), and in Patients With SDH-deficient Gastrointestinal Stromal Tumor (GIST)

Active, not recruiting
2
48
US
Biopsy, BIOPSY_TYPE, Bx, Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Computed Tomography, CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, Computerized Tomography (CT) scan, CT, CT Scan, tomography, Magnetic Resonance Imaging, Magnetic Resonance, Magnetic Resonance Imaging (MRI), Magnetic resonance imaging (procedure), Magnetic Resonance Imaging Scan, Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance, MR, MR Imaging, MRI, MRI Scan, MRIs, NMR Imaging, NMRI, Nuclear Magnetic Resonance Imaging, sMRI, Structural MRI, Positron Emission Tomography, Medical Imaging, Positron Emission Tomography, PET, PET Scan, Positron emission tomography (procedure), Positron Emission Tomography Scan, Positron-Emission Tomography, proton magnetic resonance spectroscopic imaging, PT, Rogaratinib, BAY-1163877, BAY1163877
National Cancer Institute (NCI)
Locally Advanced Gastrointestinal Stromal Tumor, Locally Advanced Sarcoma, Metastatic Gastrointestinal Stromal Tumor, Metastatic Sarcoma, Stage III Gastric and Omental Gastrointestinal Stromal Tumor AJCC v8, Stage III Small Intestinal, Esophageal, Colorectal, Mesenteric, and Peritoneal Gastrointestinal Stromal Tumor AJCC v8, Stage IV Gastric and Omental Gastrointestinal Stromal Tumor AJCC v8, Stage IV Small Intestinal, Esophageal, Colorectal, Mesenteric, and Peritoneal Gastrointestinal Stromal Tumor AJCC v8
01/25
01/25
NCT05601232: A Phase II Study by Using CICS-1 and SPM-011 Commissioned by CICS and STELLA PHARMA

Recruiting
2
10
Japan
BNCT
Stella Pharma Corporation, Cancer Intelligence Care Systems, Inc.
Unresectable Angiosarcoma
07/24
04/25
NCT02523040: A Study of Lenalidomide for Adult Histiocyte Disorders

Active, not recruiting
2
12
US
Lenalidomide, Revlimid
Dana-Farber Cancer Institute, Celgene
Langerhans Cell Histiocytosis (LCH), Histiocytoses Erdheim-chester Disease, Histiocytic Sarcoma (HS)
02/24
08/24
NCT04288375: Dose Reduction of Postoperative Radiation for Soft Tissue Sarcoma of the Arms and Legs

Recruiting
2
60
US
Intensity-modulated radiation therapy (IMRT)
Memorial Sloan Kettering Cancer Center, National Institutes of Health (NIH)
Soft Tissue Sarcoma
02/25
02/25
ChonDRAgon, NCT04950075: Study of INBRX-109 in Conventional Chondrosarcoma

Recruiting
2
201
Europe, US, RoW
INBRX-109, Placebo
Inhibrx, Inc.
Conventional Chondrosarcoma
12/24
06/25
NCT05497843: Chiauranib for Advanced or Unresectable Soft Tissue Sarcoma(STS)

Recruiting
2
40
RoW
Chiauranib, CS2164
Chipscreen Biosciences, Ltd.
Soft Tissue Sarcoma
02/24
06/24
NCT06217003: Trilaciclib Combined With Chemotherapy for Perioperative Treatment of Osteosarcoma

Not yet recruiting
2
20
RoW
Trilaciclib
The First Affiliated Hospital of Xinxiang Medical College
Osteosarcoma
02/25
08/25
NCT06277154: MASCT-I Combined With Doxorubicin and Ifosfamide for First-line Treatment of Advanced Soft Tissue Sarcoma

Not yet recruiting
2
148
RoW
MASCT-I, Doxorubicin, Doxorubicin hydrochloride for Injection, Ifosfamide, Ifosfamide for Injection
HRYZ Biotech Co.
Leiomyosarcoma, Liposarcoma, Synovial Sarcoma, Angiosarcoma, Undifferentiated Pleomorphic Sarcoma, Epithelioid Sarcoma, Malignant Peripheral Nerve Sheath Tumors, Fibrosarcoma, Pleomorphic Rhabdomyosarcoma, Endometrial Stromal Sarcoma, Desmoplastic Small Round Cell Tumor
02/26
02/27
NCT05926700: Efficacy and Safety of Cadonilimab Plus Anlotinib in Advanced STS That Failed the Previous First-line Standard Treatment

Recruiting
2
27
RoW
Candonilimab
Second Affiliated Hospital, School of Medicine, Zhejiang University
Soft Tissue Sarcoma
08/24
01/25
TRABEPIO, NCT04794127: Study on Trabectedin in Combination With Pioglitazone in Patients Myxoid Liposarcomas With Stable Disease After T Alone.

Recruiting
2
10
Europe
Trabectedin, Trabectedine, Pioglitazone Oral Product, Pioglitazone
Mario Negri Institute for Pharmacological Research, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Humanitas Hospital, Italy
Liposarcoma, Myxoid, Liposarcoma, Dedifferentiated, Liposarcoma, Round Cell
12/24
02/25
NCT01149850: Bevacizumab and Temozolomide in Treating Older Patients With Newly-Diagnosed Glioblastoma Multiforme or Gliosarcoma

Completed
2
50
US
bevacizumab, anti-VEGF humanized monoclonal antibody, anti-VEGF monoclonal antibody, anti-VEGF rhuMAb, Avastin, recombinant humanized anti-VEGF monoclonal antibody, rhuMAb VEGF, temozolomide, CCRG-81045, M & B 39831, SCH 52365, Temodal, Temodar, TMZ, laboratory biomarker analysis, immunohistochemistry staining method, immunohistochemistry, microarray analysis, gene expression profiling, DNA methylation analysis
Jonsson Comprehensive Cancer Center, Genentech, Inc.
Giant Cell Glioblastoma, Glioblastoma, Gliosarcoma
12/23
12/23
ZW25-IST-2, NCT04513665: ZW25 in Women With Endometrial Cancers

Completed
2
17
US
ZW25
Memorial Sloan Kettering Cancer Center, Zymeworks BC Inc.
Endometrial Cancer, Carcinosarcoma
03/24
03/24
BIOVAS, NCT04072042: BIOmarker Driven Trial of VEGFR2 Inhibitor in Advanced Sarcoma

Recruiting
2
30
RoW
Apatinib monotherapy, VEGFR inhibitor; Rivoceranib
Ruijin Hospital
Sarcoma
02/24
05/24
NCT04551430: Cabozantinib Combined With PD-1 and CTLA-4 Inhibition in Metastatic Soft Tissue Sarcoma

Active, not recruiting
2
105
US
Cabozantinib, Nivolumab, Opdivo, Ipilimumab, Yervoy
Washington University School of Medicine, Exelixis, Bristol-Myers Squibb
Metastatic Soft-tissue Sarcoma
06/25
06/30
NCT03866382: Testing the Effectiveness of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) With One Anti-cancer Targeted Drug (Cabozantinib) for Rare Genitourinary Tumors

Recruiting
2
314
US
Bone Scan, Bone Scintigraphy, Cabozantinib S-malate, BMS-907351, Cabometyx, Cometriq, XL-184, XL184, Computed Tomography, CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, Computerized Tomography (CT) scan, CT, CT Scan, tomography, Ipilimumab, Anti-Cytotoxic T-Lymphocyte-Associated Antigen-4 Monoclonal Antibody, BMS-734016, Ipilimumab Biosimilar CS1002, MDX-010, MDX-CTLA4, Yervoy, Magnetic Resonance Imaging, Magnetic Resonance, Magnetic Resonance Imaging (MRI), Magnetic resonance imaging (procedure), Magnetic Resonance Imaging Scan, Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance, MR, MR Imaging, MRI, MRI Scan, MRIs, NMR Imaging, NMRI, Nuclear Magnetic Resonance Imaging, sMRI, Structural MRI, Nivolumab, ABP 206, BCD-263, BMS-936558, CMAB819, MDX-1106, NIVO, Nivolumab Biosimilar ABP 206, Nivolumab Biosimilar BCD-263, Nivolumab Biosimilar CMAB819, ONO-4538, Opdivo, Positron Emission Tomography, Medical Imaging, Positron Emission Tomography, PET, PET Scan, Positron emission tomography (procedure), Positron Emission Tomography Scan, Positron-Emission Tomography, proton magnetic resonance spectroscopic imaging, PT
National Cancer Institute (NCI)
Bladder Adenocarcinoma, Bladder Clear Cell Adenocarcinoma, Bladder Mixed Adenocarcinoma, Bladder Neuroendocrine Carcinoma, Bladder Small Cell Neuroendocrine Carcinoma, Bladder Squamous Cell Carcinoma, Chromophobe Renal Cell Carcinoma, Collecting Duct Carcinoma, Invasive Bladder Giant Cell Urothelial Carcinoma, Invasive Bladder Lymphoepithelioma-Like Carcinoma, Invasive Bladder Nested Urothelial Carcinoma, Invasive Bladder Plasmacytoid Urothelial Carcinoma, Invasive Bladder Sarcomatoid Urothelial Carcinoma, Invasive Bladder Urothelial Carcinoma, Kidney Medullary Carcinoma, Large Cell Neuroendocrine Carcinoma, Malignant Testicular Leydig Cell Tumor, Malignant Testicular Sertoli Cell Tumor, Metastatic Bladder Carcinoma, Metastatic Bladder Clear Cell (Glycogen-Rich) Urothelial Carcinoma, Metastatic Bladder Giant Cell Urothelial Carcinoma, Metastatic Bladder Large Cell Neuroendocrine Carcinoma, Metastatic Bladder Lipid-Rich Urothelial Carcinoma, Metastatic Bladder Micropapillary Urothelial Carcinoma, Metastatic Bladder Plasmacytoid Urothelial Carcinoma, Metastatic Bladder Sarcomatoid Urothelial Carcinoma, Metastatic Bladder Small Cell Neuroendocrine Carcinoma, Metastatic Bladder Squamous Cell Carcinoma, Metastatic Chromophobe Renal Cell Carcinoma, Metastatic Kidney Medullary Carcinoma, Metastatic Malignant Genitourinary System Neoplasm, Metastatic Papillary Renal Cell Carcinoma, Metastatic Penile Carcinoma, Metastatic Prostate Small Cell Neuroendocrine Carcinoma, Metastatic Sarcomatoid Renal Cell Carcinoma, Metastatic Urethral Carcinoma, Papillary Renal Cell Carcinoma, Sarcomatoid Renal Cell Carcinoma, Stage IV Bladder Cancer AJCC v8, Stage IV Penile Cancer AJCC v8, Stage IV Renal Cell Cancer AJCC v8, Stage IV Urethral Cancer AJCC v8, Stage IVB Prostate Cancer AJCC v8, Urachal Adenocarcinoma, Urethral Clear Cell Adenocarcinoma
02/25
02/25
NCT03069378: A Study of Talimogene Laherparepvec (T-VEC) in Combination With Pembrolizumab in Patients With Metastatic and/or Locally Advanced Sarcoma

Active, not recruiting
2
41
US
Talimogene Laherparepvec (T-VEC), Pembrolizumab
Memorial Sloan Kettering Cancer Center, Amgen, Merck Sharp & Dohme LLC
Sarcoma, Epithelioid Sarcoma, Cutaneous Angiosarcoma
03/25
03/25
EREMISS, NCT03793361: Phase II Study of Regorafenib as Maintenance Therapy

Active, not recruiting
2
127
Europe
Regorafenib, stivarga, Placebo
Centre Oscar Lambret
Metastatic Soft Tissue Sarcoma
03/24
03/25
NCT04172805: Anlotinib Combined With Toripalimab in Refractory and Advanced Soft-tissue Sarcoma

Recruiting
2
70
RoW
anlotinib and toripalimab, Anlotinib Hydrochloride
Sun Yat-sen University
Sarcoma,Soft Tissue
03/24
05/24
NCT04784247: Lenvatinib and Pembrolizumab in People With Advanced Soft Tissue Sarcoma

Active, not recruiting
2
52
US
Lenvatinib, Pembrolizumab
Memorial Sloan Kettering Cancer Center, Merck Sharp & Dohme LLC, Parker Institute for Cancer Immunotherapy
Advanced Sarcoma
03/25
03/25
BETA-PRIME, NCT04673942: A Study of AdAPT-001 in Subjects With Sarcoma and Refractory Solid Tumors

Recruiting
2
140
US
AdAPT-001, Checkpoint Inhibitor, Immune
EpicentRx, Inc.
Solid Tumor, Adult, Cancer, Neoplasms, Sarcoma, Sarcoma,Soft Tissue, Chondrosarcoma
12/25
03/27
NCT05275426: A Study of LY2880070 and Gemcitabine in People With Ewing Sarcoma,Ewing-Like Sarcoma, and Desmoplastic Small Round Cell Tumor

Recruiting
2
24
US
LY2880070, Gemcitabine
Memorial Sloan Kettering Cancer Center
Ewing Sarcoma, Ewing-Like Sarcoma
03/25
03/25
NCT06176989: Enasidenib in IDH2-Mutated Malignant Sinonasal and Skull Base Tumors

Recruiting
2
30
US
Enasidenib
National Cancer Institute (NCI)
Metastatic Chondrosarcoma, Locally Advanced Chondrosarcoma, Metastatic Sinonasal Adenocarcinoma, Locally Advanced Sinonasal Adenocarcinoma, Metastatic Large-cell Neuroendocrine Carcinoma, Locally Advanced Large-cell Neuroendocrine Carcinoma, Metastatic Olfactory Neuroblastoma, Locally Advanced Olfactory Neuroblastoma, Metastatic Sinonasal Undifferentiated Carcinoma, Locally Advanced Sinonasal Undifferentiated Carcinoma
12/27
12/30
NCT01391962: Sunitinib or Cediranib for Alveolar Soft Part Sarcoma

Active, not recruiting
2
34
US
Cediranib, Sunitinib
National Cancer Institute (NCI)
Sarcoma, Alveolar Soft Part
11/23
03/25
NCT02399371: Pembrolizumab in Treating Patients With Malignant Mesothelioma

Active, not recruiting
2
65
US
Pembrolizumab, Keytruda, Lambrolizumab, MK-3475, SCH 900475, Laboratory Biomarker Analysis, Pharmacogenomic Study
University of Chicago, National Cancer Institute (NCI)
Biphasic Mesothelioma, Epithelioid Mesothelioma, Peritoneal Malignant Mesothelioma, Pleural Biphasic Mesothelioma, Pleural Epithelioid Mesothelioma, Pleural Malignant Mesothelioma, Pleural Sarcomatoid Mesothelioma, Recurrent Peritoneal Malignant Mesothelioma, Recurrent Pleural Malignant Mesothelioma, Sarcomatoid Mesothelioma
03/26
03/26
NCT02799485: sEphB4-HSA in Treating Patients With Kaposi Sarcoma

Recruiting
2
20
US
Laboratory Biomarker Analysis, Pharmacological Study, Quality-of-Life Assessment, Quality of Life Assessment, Recombinant EphB4-HSA Fusion Protein, sEphB4-HSA
AIDS Malignancy Consortium, National Cancer Institute (NCI), Vasgene Therapeutics, Inc, The Emmes Company, LLC, University of Arkansas
Skin Kaposi Sarcoma
03/24
04/24
ADVL1823, NCT03834961: Larotrectinib in Treating Patients With Previously Untreated TRK Fusion Solid Tumors and TRK Fusion Relapsed Acute Leukemia

Active, not recruiting
2
70
Canada, US
Larotrectinib Sulfate, ARRY 470 Sulfate, LOXO 101 Sulfate, LOXO-101 Sulfate, Vitrakvi
Children's Oncology Group, National Cancer Institute (NCI)
Central Nervous System Neoplasm, Infantile Fibrosarcoma, Recurrent Acute Leukemia, Refractory Acute Leukemia, Solid Neoplasm
09/24
09/24
ChiCTR2200059629: Eribulin plus anlotinib for the treatment of refractory and advanced soft tissue sarcoma after failure of standard therapy：a prospective, open-label, single arm and single center clinical study

Recruiting
2
30
 
Eribulin plus anlotinib
Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences; Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, partly self-funded，partly provied by Eisai China Inc.
Soft tissue Sarcoma
 
 
NCT05301283: Habitat Escalated Adaptive Therapy (HEAT), With Neoadjuvant Radiation for Soft Tissue Sarcoma

Recruiting
2
43
US
Intensity Modulated Radiation Therapy (IMRT), MRI
H. Lee Moffitt Cancer Center and Research Institute, Viewray Inc.
High Grade Sarcoma
06/24
03/25
ChiCTR2200060410: Prospective clinical study of preoperative induction therapy with arotinib for locally advanced head and neck sarcoma

Not yet recruiting
2
31
 
2 cycles of neoadjuvant therapy with anlotinib
Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine; Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, self-funded
head and neck sarcoma
 
 
NCT05708391: Radiotherapy Combined With Realgar-Indigo Naturalis Formula (RIF) in the Treatment of Rhabdomyosarcoma(RMS) in Children

Not yet recruiting
2
53
NA
Realgar-Indigo Naturalis Formulation, Radiotherapy
Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Rhabdomyosarcoma, Child
03/24
12/24
ERASING, NCT03840772: Eribulin in Advanced Solitary Fibrous Tumor

Recruiting
2
16
Europe
Eribulin, Intervention under investigation
Italian Sarcoma Group, Eisai Inc.
Solitary Fibrous Tumor
04/24
04/24
NCT04332874: A Study of Pembrolizumab Plus Local Chemotherapy Using Isolated Limb Infusion (ILI) for Patients With Sarcoma in the Arm or Leg

Recruiting
2
30
US
Isolated Limb Infusion, ILI, Pembrolizumab, infusion of melphalan and dactinomycin
Memorial Sloan Kettering Cancer Center
Sarcoma, Myxofibrosarcoma, Undifferentiated Pleomorphic Sarcoma, Alveolar Soft Part Sarcoma
04/25
04/25
ChiCTR2200065746: Clinical study of chidamide combined with tislelizumab in the treatment of advanced osteosarcoma

Not yet recruiting
2
23
China
chidamide combined with tislelizumab
Beijing Jishuitan Hospital ; Beijing Jishuitan Hospital, self-funded
osteosarcoma
 
 
NCT05496569: TQB3616 Capsules in the Treatment of Dedifferentiated Liposarcoma

Not yet recruiting
2
118
RoW
TQB3616 capsule, TQB3616 placebo
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Dedifferentiated Liposarcoma
04/24
12/24
PEMBROCABOSARC, NCT05182164: Combination of Pembrolizumab and Cabozantinib in Patients With Advanced Sarcomas

Recruiting
2
119
Europe
Association of pembrolizumab + cabozantinib
Institut Bergonié, Ipsen, MSD France
Soft Tissue Sarcoma Adult, Advanced Soft-tissue Sarcoma, Ewing Sarcoma, Osteosarcoma, Undifferentiated Pleomorphic Sarcoma
04/24
10/25
NRG-BN001, NCT02179086: Dose-Escalated Photon IMRT or Proton Beam Radiation Therapy Versus Standard-Dose Radiation Therapy and Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma

Active, not recruiting
2
624
Canada, US
3-dimensional conformal radiation therapy, 3D conformal radiation therapy, 3D-CRT, intensity-modulated radiation therapy, IMRT, photon beam radiation therapy, proton beam radiation therapy, temozolomide, SCH 52365, Temodal, Temodar, TMZ, laboratory biomarker analysis
NRG Oncology, National Cancer Institute (NCI), Radiation Therapy Oncology Group
Adult Giant Cell Glioblastoma, Adult Glioblastoma, Adult Gliosarcoma
05/24
05/26
SARC038, NCT04803877: Phase 2 Study of Regorafenib and Nivolumab in Osteosarcoma

Active, not recruiting
2
48
US
Regorafenib 40 MG, Regorafenib 20MG, Nivolumab
Sarcoma Alliance for Research through Collaboration
Osteosarcoma, Osteosarcoma in Children, Osteosarcoma Recurrent, Osteosarcoma Metastatic
05/24
06/26
ChiCTR2200060659: Phase II study of neoadjuvant hypofractionated radiotherapy combined with in situ immunotherapy for resectable soft tissue sarcoma

Recruiting
2
30
 
neoadjuvant hypofractionated radiotherapy + in situ immunotherapy ;neoadjuvant hypofractionated radiotherapy
Nanjing Drum Tower Hospital，The Affiliated Hospital of Nanjing University Medical School; Nanjing Drum Tower Hospital，The Affiliated Hospital of Nanjing University Medical School, National Natural Science Foundation of China
Soft Tissue Sarcoma
 
 
ACCeSs, NCT04274023: Study on TSR-042 in Advanced Clear Cell Sarcoma

Terminated
2
3
Europe
TSR-042
Italian Sarcoma Group, GlaxoSmithKline
Sarcoma, Clear Cell
01/24
01/24
NCT06367075: A Trial of Cadonilimab With Adriamycin in Patients With Advanced Soft Tissue Sarcoma

Not yet recruiting
2
53
NA
Cadonilimab, AK104, Adriamycin, Doxorubicin
Wuhan Union Hospital, China, Sun Yat-sen University, Xiangya Hospital of Central South University, Yunnan Cancer Hospital, The Affiliated Hospital Of Guizhou Medical University, First Affiliated Hospital of Guangxi Medical University
Advanced Soft-tissue Sarcoma
03/27
03/29
Pan-MSI-ACSE, NCT06333314: Dostarlimab for Locally Advanced or Metastatic Cancer (Non-colorectal/Non-endometrial) With Tumor dMMR/MSI

Not yet recruiting
2
120
Europe
Dostarlimab, Chemotherapy
UNICANCER, National Cancer Institute, France, GlaxoSmithKline
Pancreatic Adenocarcinoma, Ampulla of Vater Carcinoma, Adrenocortical Carcinoma, Neuroendocrine Carcinoma, Soft Tissue Sarcoma, Small Bowel Adenocarcinoma, Duodenum Adenocarcinoma, Gastric Adenocarcinoma
10/28
09/30
PERELI, NCT06389799: A Phase 2, Open Label Study of PEmigatinib and REtifanlimab in Advanced Dedifferentiated LIposarcoma

Not yet recruiting
2
33
Europe
Pemigatinib, Retifanlimab
Lund University Hospital
Dedifferentiated Liposarcoma
12/27
12/28
MARS, NCT06436612: Study of Magnetic Resonance Image and Computed Tomography-Guided Stereotactic Body Radiation Therapy for Abdominopelvic Sarcomas ( Trial)

Recruiting
2
20
US
Magnetic Resonance Image and Computed Tomography-Guided Stereotactic Body Radiation Therapy, Pre-operative stereotactic body radiation therapy (SBRT)
Jonsson Comprehensive Cancer Center
Abdominopelvic Sarcomas
10/24
10/25
NCT02601950 / 2015-002469-41: A Study of Tazemetostat in Adult Participants With Soft Tissue Sarcoma

Checkmark Data from a trial for epithelioid sarcoma and follicular lymphoma
Oct 2020 - Oct 2020: Data from a trial for epithelioid sarcoma and follicular lymphoma
Checkmark In adult patients with INI1-negative tumors
Oct 2018 - Oct 2018: In adult patients with INI1-negative tumors
Checkmark Epithelioid sarcoma cohort at ESMO 2018
More
Completed
2
267
Europe, Canada, US, RoW
Tazemetostat, EPZ-6438, E7438, IPN60200
Epizyme, Inc.
Malignant Rhabdoid Tumors (MRT), Rhabdoid Tumors of the Kidney (RTK), Atypical Teratoid Rhabdoid Tumors (ATRT), Selected Tumors With Rhabdoid Features, Synovial Sarcoma, INI1-negative Tumors, Malignant Rhabdoid Tumor of Ovary, Renal Medullary Carcinoma, Epithelioid Sarcoma, Poorly Differentiated Chordoma (or Other Chordoma With Sponsor Approval), Any Solid Tumor With an EZH2 GOF Mutation
02/24
02/24
NCT03556384: Temozolomide (TMZ) In Advanced Succinate Dehydrogenase (SDH)-Mutant/Deficient Gastrointestinal Stromal Tumor (GIST)

Active, not recruiting
2
23
US
Temozolomide, TEMODAR®
Adam Burgoyne, MD, PhD
Gastrointestinal Stromal Tumors, Sdh, GIST, Cancer
06/24
06/25
CONGRATS, NCT04095208 / 2019-002332-81: Combination of Nivolumab Plus Relatlimab in Patients With Advanced or Metastatic Soft-tissue Sarcoma: a Proof-of-concept Randomized Phase II Study

Recruiting
2
67
Europe
Association of Nivolumab + Relatlimab, Nivolumab
Institut Bergonié, Bristol-Myers Squibb
Soft Tissue Sarcoma Adult, Advanced Cancer
06/24
12/25
NCT04417062: Olaparib With Ceralasertib in Recurrent Osteosarcoma

Recruiting
2
63
US
Olaparib, Lynparza, Ceralasertib, AZD6738
Dana-Farber Cancer Institute, Osteosarcoma Institute, AstraZeneca
Osteosarcoma, Osteosarcoma Recurrent
06/24
06/25
ENVASARC, NCT04480502: Envafolimab And Envafolimab With Ipilimumab In Patients With Undifferentiated Pleomorphic Sarcoma Or Myxofibrosarcoma

Active, not recruiting
2
207
Europe, US
Envafolimab, KN035, Ipilimumab, Yervoy
Tracon Pharmaceuticals Inc.
Undifferentiated Pleomorphic Sarcoma, Myxofibrosarcoma
10/24
10/24
NCT05481645: Efficacy and Safety of TQB2450 Injection Combined With Chemotherapy ± Anlotinib Hydrochloride Capsules for Advanced Endometrial Cancer or Sarcoma of Uterus.

Recruiting
2
79
RoW
TQB2450 injection, Anlotinib Hydrochloride Capsule, Carboplatin Injection, Paclitaxel Injection, Doxorubicin Hydrochloride Injection, Gemcitabine Hydrochloride Injection, Docetaxel injection
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Advanced Endometrial Cancer, Sarcoma of Uterus
06/24
12/24
hSTAR GBM, NCT05052957: (Hematopoetic Stem Cell (HPC) Rescue for GBM)

Recruiting
2
16
US
P140K-MGMT, O6-benzylguanine, BG, Photon Based Radiotherapy, temozolomide, TMZ, Filgrastim, G-CSF,Granulocyte-Colony Stimulating Factor, carmustine, BCNU,bis-chloronitrosourea
Leland Metheny, National Cancer Institute (NCI)
Glioblastoma Multiforme, Glioblastoma Multiforme, Adult, Supratentorial Glioblastoma, Supratentorial Gliosarcoma
06/24
12/24
IntriNSiC, NCT05329792 / 2021-006041-36: L19IL2/L19TNF in Skin Cancer Patients

Recruiting
2
70
Europe
L19IL2/L19TNF, bifikafusp alfa/onfekafusp alfa
Philogen S.p.A., Philogen S.p.A.
BCC - Basal Cell Carcinoma, SCC - Squamous Cell Carcinoma, Merkel Cell Carcinoma, Keratoacanthoma of Skin, Malignant Adnexal Tumors of the Skin (MATS), Tumors From Cutaneous T-cell Lymphoma (CTCL), Kaposi Sarcoma
06/24
12/24
NCT06416085: Psilocybin-assisted Existential, Attachment and RelationaL (PEARL) Therapy for Patients With Advanced Cancer

Not yet recruiting
2
15
Canada
Psilocybin
University Health Network, Toronto
Advanced Cancer, Stage IV Solid Tumor Cancer, Stage IV Sarcoma of Bone, Stage IV Lymphoma, Stage IV Melanoma, Endocrine Cancer
01/26
06/26
NCT06208748: SARC044: A Phase II Trial of Bezuclastinib in Combination With Sunitinib in Patients With GIST

Recruiting
2
40
US
Bezuclastinib in combination with sunitinib
Sarcoma Alliance for Research through Collaboration, Cogent Biosciences, Inc., Dana-Farber Cancer Institute, The Life Raft Group
Gastrointestinal Stromal Tumors, GIST
06/26
06/27
CabOSTar, NCT06341712: Effects of Maintenance Cabozantinib+BSC Versus BSC in Children and AYA With Osteosarcoma

Not yet recruiting
2
90
NA
Cabozantinib, Best Supportive Care (BSC)
Ipsen
Osteosarcoma, Osteosarcoma in Children, Osteosarcoma in Adolescents and Young Adults
10/26
06/28
NCT06422806: Measuring if Immunotherapy Plus Chemotherapy is Better Than Chemotherapy Alone for Patients With Aggressive Poorly Differentiated Sarcomas

Not yet recruiting
2
160
NA
Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Diagnostic Imaging, Medical Imaging, Doxorubicin, Adriablastin, Hydroxydaunomycin, Hydroxyl Daunorubicin, Hydroxyldaunorubicin, Echocardiography, EC, Multigated Acquisition Scan, Blood Pool Scan, Equilibrium Radionuclide Angiography, Gated Blood Pool Imaging, Gated Heart Pool Scan, MUGA, MUGA Scan, Multi-Gated Acquisition Scan, Radionuclide Ventriculogram Scan, Radionuclide Ventriculography, RNVG, SYMA Scanning, Synchronized Multigated Acquisition Scanning, Pembrolizumab, BCD-201, Keytruda, Lambrolizumab, MK-3475, Pembrolizumab Biosimilar BCD-201, Pembrolizumab Biosimilar QL2107, QL2107, SCH 900475
National Cancer Institute (NCI)
Stage III Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8, Stage IV Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8, Undifferentiated Pleomorphic Sarcoma
06/26
06/26
NCI-2018-00918, NCT03449108: LN-145 or LN-145-S1 in Treating Patients With Relapsed or Refractory Ovarian Cancer, Triple Negative Breast Cancer (TNBC), Anaplastic Thyroid Cancer, Osteosarcoma, or Other Bone and Soft Tissue Sarcomas

Active, not recruiting
2
30
US
Aldesleukin, 125-L-Serine-2-133-interleukin 2, Proleukin, r-serHuIL-2, Recombinant Human IL-2, Recombinant Human Interleukin-2, Autologous Tumor Infiltrating Lymphocytes LN-145, Autologous TILs LN-145, Autologous Tumor-infiltrating Lymphocytes LN-145, LN-145, LN145, Autologous Tumor Infiltrating Lymphocytes LN-145-S1, Autologous TILs LN-145-S1, Autologous Tumor-infiltrating Lymphocytes LN-145-S1, LN 145-S1, LN-145-S1, LN145-S1, Cyclophosphamide, (-)-Cyclophosphamide, 2H-1,3,2-Oxazaphosphorine, 2-[bis(2-chloroethyl)amino]tetrahydro-, 2-oxide, monohydrate, Carloxan, Ciclofosfamida, Ciclofosfamide, Cicloxal, Clafen, Claphene, CP monohydrate, CTX, CYCLO-cell, Cycloblastin, Cycloblastine, Cyclophospham, Cyclophosphamid monohydrate, Cyclophosphamide Monohydrate, Cyclophosphamidum, Cyclophosphan, Cyclophosphane, Cyclophosphanum, Cyclostin, Cyclostine, Cytophosphan, Cytophosphane, Cytoxan, Fosfaseron, Genoxal, Genuxal, Ledoxina, Mitoxan, Neosar, Revimmune, Syklofosfamid, WR- 138719, Fludarabine, Fluradosa, Ipilimumab, Anti-Cytotoxic T-Lymphocyte-Associated Antigen-4 Monoclonal Antibody, BMS-734016, Ipilimumab Biosimilar CS1002, MDX-010, MDX-CTLA4, Yervoy, Nivolumab, BMS-936558, CMAB819, MDX-1106, NIVO, Nivolumab Biosimilar CMAB819, ONO-4538, Opdivo, Quality-of-Life Assessment, Quality of Life Assessment, Questionnaire Administration
M.D. Anderson Cancer Center, Iovance Biotherapeutics, Inc., National Cancer Institute (NCI)
Bone Sarcoma, Dedifferentiated Chondrosarcoma, Giant Cell Tumor of Bone, Malignancy in Giant Cell Tumor of Bone, Malignant Solid Neoplasm, Ovarian Carcinosarcoma, Platinum-Resistant Ovarian Carcinoma, Poorly Differentiated Thyroid Gland Carcinoma, Recurrent Osteosarcoma, Recurrent Ovarian Carcinoma, Refractory Osteosarcoma, Soft Tissue Sarcoma, Thyroid Gland Anaplastic Carcinoma, Thyroid Gland Squamous Cell Carcinoma, Undifferentiated High Grade Pleomorphic Sarcoma of Bone, Triple Negative Breast Cancer
06/25
06/25
DOSa, NCT04668300: Oleclumab and Durvalumab for the Treatment of Recurrent, Refractory, or Metastatic Sarcoma

Recruiting
2
75
US
Durvalumab, Imfinzi, Immunoglobulin G1, Anti-(Human Protein B7-H1) (Human Monoclonal MEDI4736 Heavy Chain), Disulfide with Human Monoclonal MEDI4736 Kappa-chain, Dimer, MEDI-4736, MEDI4736, Oleclumab, Anti-CD73 Monoclonal Antibody MEDI9447, MEDI9447
M.D. Anderson Cancer Center, National Cancer Institute (NCI)
Metastatic Angiosarcoma, Metastatic Dedifferentiated Liposarcoma, Metastatic Osteosarcoma, Recurrent Angiosarcoma, Recurrent Dedifferentiated Liposarcoma, Recurrent Osteosarcoma, Refractory Dedifferentiated Liposarcoma, Refractory Osteosarcoma
06/24
06/24
ISG-ARTICLE, NCT04383119: Trial in Patients With Metastatic or Locally Advanced Leiomyosarcoma

Recruiting
2
100
Europe
Trabectedin, Trabectedin arm, Gemcitabine, Gemcitabine arm, No Intervention: Observational Cohort
Italian Sarcoma Group, PharmaMar
Leiomyosarcoma of Ovary, Soft Tissue Sarcoma
06/24
09/24
 

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