- |||||||||| Trial completion, Trial completion date, Trial primary completion date: SOMMEDREP: Sleep Respiratory Disorders Evaluation in Sickle Cell Disease Children (clinicaltrials.gov) - Mar 14, 2019
P=N/A, N=62, Completed, Completed --> Terminated; Initiation of CMS BMT study for sickle-cell disease operating under NCT01166009 made further accrual to this study impossible. Active, not recruiting --> Completed | Trial completion date: Jan 2019 --> Aug 2018 | Trial primary completion date: Jan 2019 --> Aug 2018
- |||||||||| Enrollment change, Trial completion date, Trial primary completion date: Bi-Level Positive Airway Ventilation for Acute Chest Syndrome (clinicaltrials.gov) - Dec 12, 2018
P=N/A, N=3, Terminated, Trial completion date: Aug 2018 --> Jan 2019 | Trial primary completion date: Aug 2018 --> Jan 2019 N=60 --> 3 | Trial completion date: Jul 2014 --> Sep 2016 | Trial primary completion date: Jul 2014 --> Sep 2016
- |||||||||| Trial completion, Enrollment change, Trial completion date, Trial primary completion date: Pain Management in Children and Young Adults With Sickle Cell Disease (clinicaltrials.gov) - Jul 6, 2018
P2, N=90, Completed, Active, not recruiting --> Completed Recruiting --> Completed | N=190 --> 90 | Trial completion date: May 2018 --> Jan 2018 | Trial primary completion date: May 2018 --> Jan 2018
- |||||||||| Sanguinate (PEGylated Carboxyhemoglobin bovine) / Prolong Pharma
Enrollment change, Trial withdrawal: Safety and Pharmacokinetics of SANGUINATE (clinicaltrials.gov) - Jun 2, 2018 P1, N=0, Withdrawn, Recruiting --> Completed | N=190 --> 90 | Trial completion date: May 2018 --> Jan 2018 | Trial primary completion date: May 2018 --> Jan 2018 N=15 --> 0 | Suspended --> Withdrawn
- |||||||||| montelukast / Generic mfg.
Trial completion, Trial completion date, Trial primary completion date: Phase 2 Study of Montelukast for the Treatment of Sickle Cell Anemia (clinicaltrials.gov) - Apr 3, 2018 P2, N=46, Completed, N=15 --> 0 | Suspended --> Withdrawn Active, not recruiting --> Completed | Trial completion date: Oct 2018 --> Mar 2018 | Trial primary completion date: Oct 2018 --> Mar 2018
- |||||||||| montelukast / Generic mfg.
Enrollment closed: Phase 2 Study of Montelukast for the Treatment of Sickle Cell Anemia (clinicaltrials.gov) - Mar 26, 2018 P2, N=63, Active, not recruiting, Active, not recruiting --> Completed | Trial completion date: Oct 2018 --> Mar 2018 | Trial primary completion date: Oct 2018 --> Mar 2018 Recruiting --> Active, not recruiting
- |||||||||| Lexiscan (regadenoson) / GE Healthcare, Astellas, Gilead
Trial completion: A Phase II Trial of Regadenoson in Sickle Cell Anemia (clinicaltrials.gov) - Feb 7, 2018 P2, N=100, Completed, Active, not recruiting --> Completed | Trial completion date: Apr 2017 --> May 2017 Recruiting --> Completed
- |||||||||| Trial completion: Heart Disease in Sickle Cell Anemia (clinicaltrials.gov) - Jun 30, 2017
P=N/A, N=120, Completed, Completed --> Terminated; The study terminated early due to slow accrual. Recruiting --> Completed
- |||||||||| propranolol ER / Generic mfg.
Enrollment change, Trial termination, Trial primary completion date: Propanolol and Red Cell Adhesion Non-asthmatic Children Sickle Cell Disease (clinicaltrials.gov) - Jun 8, 2017 P1, N=9, Terminated, Recruiting --> Completed N=20 --> 9 | Recruiting --> Terminated | Trial primary completion date: Dec 2017 --> Nov 2012; Inability to recruit patients into the study.
- |||||||||| Amevive (alefacept) / Astellas
Trial termination: Alefacept and Allogeneic Hematopoietic Stem Cell Transplantation (clinicaltrials.gov) - Jun 7, 2017 P=N/A, N=3, Terminated, N=20 --> 9 | Recruiting --> Terminated | Trial primary completion date: Dec 2017 --> Nov 2012; Inability to recruit patients into the study. Suspended --> Terminated; drug company is no longer making the drug
- |||||||||| Thymoglobulin (anti-thymocyte globulin (rabbit)) / Sanofi
Trial completion, Enrollment change, Trial primary completion date: Bone Marrow Transplantation in Young Adults With Severe Sickle Cell Disease (clinicaltrials.gov) - May 15, 2017 P2, N=22, Completed, Recruiting --> Completed | Trial primary completion date: May 2017 --> Aug 2016 Active, not recruiting --> Completed | N=15 --> 22 | Trial primary completion date: Dec 2017 --> Jun 2016
- |||||||||| Trial completion, HEOR: Decision Aid for Therapeutic Options In Sickle Cell Disease (clinicaltrials.gov) - Apr 21, 2017
P=N/A, N=120, Completed, Active, not recruiting --> Completed | N=15 --> 22 | Trial primary completion date: Dec 2017 --> Jun 2016 Active, not recruiting --> Completed
- |||||||||| Trial completion, Trial primary completion date: Molecular Phenotyping of Asthma in Sickle Cell Disease (clinicaltrials.gov) - Mar 28, 2017
P=N/A, N=99, Completed, Trial primary completion date: Feb 2017 --> Nov 2017 Active, not recruiting --> Completed | Trial primary completion date: Sep 2016 --> Feb 2016
- |||||||||| losartan potassium / Generic mfg.
Trial completion, Phase classification, Enrollment change: Losartan for Sickle Cell Kidney Disease (clinicaltrials.gov) - Feb 17, 2017 P, N=24, Completed, Trial primary completion date: Feb 2017 --> Feb 2019 Active, not recruiting --> Completed | Phase classification: PN/A --> P | N=40 --> 24
- |||||||||| Trial primary completion date, HEOR: Decision Aid for Therapeutic Options In Sickle Cell Disease (clinicaltrials.gov) - Feb 1, 2017
P=N/A, N=120, Active, not recruiting, N=25 --> 4 | Suspended --> Terminated | Trial primary completion date: Jan 2016 --> Jan 2015; PI moving to a different institution. Trial primary completion date: Dec 2016 --> Jul 2017
- |||||||||| fludarabine IV / Generic mfg., cyclophosphamide / Generic mfg.
Trial completion, Enrollment change: Sickle Cell Disease Conditioning for Bone Marrow Transplant (clinicaltrials.gov) - Jan 26, 2017 P1, N=8, Completed, Recruiting --> Active, not recruiting | Trial primary completion date: May 2017 --> May 2018 Suspended --> Completed | N=24 --> 8
- |||||||||| Enrollment change, Trial withdrawal, Trial primary completion date: Androgen Regulation of Priapism in Sickle Cell Disease (clinicaltrials.gov) - Jan 19, 2017
P=N/A, N=0, Withdrawn, Suspended --> Completed | N=24 --> 8 N=20 --> 0 | Not yet recruiting --> Withdrawn | Trial primary completion date: Mar 2017 --> Jan 2016
|