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23 Companies |
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18 Products |
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25 Mechanisms of Action |
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0 Trials |
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307 News |
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- ||||| Enrollment closed: EUPHRATES: Safety and Efficacy of Polymyxin B Hemoperfusion (PMX) for Septic Shock (clinicaltrials.gov) - Jun 23, 2016
P3, N=450, Active, not recruiting, Sponsor: Spectral Diagnostics (US) Inc.
Recruiting --> Active, not recruiting
- Trial completion, Trial primary completion date: TAMOF: Patient Plasma Response and Outcome in Septic Shock With Thrombocytopenia Associated Multiple Organ Failure in Children (clinicaltrials.gov) - Jun 16, 2016
P=N/A, N=86, Completed, Sponsor: Children's Healthcare of Atlanta
Recruiting --> Active, not recruiting Recruiting --> Completed | Trial primary completion date: Dec 2012 --> Feb 2012
- Trial completion, Trial primary completion date: SEPP1B: Correlation Between PTP1B Expression and Organ Failure During Sepsis (clinicaltrials.gov) - May 13, 2016
P=N/A, N=54, Completed, Sponsor: University Hospital, Rouen
Recruiting --> Completed | Trial primary completion date: Dec 2012 --> Feb 2012 Recruiting --> Completed | Trial primary completion date: Jan 2017 --> May 2016
- Trial primary completion date: Epidemiology, Acute Management, and Outcomes of Patients With Sepsis Presenting to a Referral Hospital in Western Kenya (clinicaltrials.gov) - May 6, 2016
P=N/A, N=440, Recruiting, Sponsor: Duke University
Recruiting --> Completed | Trial primary completion date: Jan 2017 --> May 2016 Trial primary completion date: Mar 2016 --> Aug 2016
- |||| Gohibic (vilobelimab) / Staidson Biopharma, InflaRx
Trial completion: SCIENS: Studying Complement Inhibition in Early, Newly Developing Septic Organ Dysfunction (clinicaltrials.gov) - Apr 26, 2016
P2, N=72, Completed, Sponsor: InflaRx GmbH
Trial primary completion date: Mar 2016 --> Aug 2016 Active, not recruiting --> Completed
- Trial primary completion date: Cerebral Oxygenation in Septic Patients Using Vasopressors - the Conscious Study (clinicaltrials.gov) - Apr 15, 2016
P=N/A, N=40, Recruiting, Sponsor: Karl-Andre Wian
Active, not recruiting --> Completed Trial primary completion date: Mar 2016 --> Jan 2017
- Trial completion, Enrollment change: Effects of Early Exercise Rehabilitation on Long-term Functional Recovery in Patients With Severe Sepsis (clinicaltrials.gov) - Apr 14, 2016
P=N/A, N=40, Completed, Sponsor: Yonsei University
Trial primary completion date: Mar 2016 --> Jan 2017 Recruiting --> Completed | N=220 --> 40
- Trial primary completion date: ASSET - a Double-Blind, Randomized Placebo-Controlled Clinical Investigation With Alteco (clinicaltrials.gov) - Apr 6, 2016
P=N/A, N=32, Recruiting, Sponsor: Alteco Medical AB
Recruiting --> Completed | N=220 --> 40 Trial primary completion date: Sep 2016 --> Apr 2017
- Solu-Cortef (hydrocortisone sodium succinate injection) / Pfizer
Trial primary completion date: ADRENAL: ADjunctive coRticosteroid trEatment iN criticAlly ilL Patients With Septic Shock (clinicaltrials.gov) - Mar 25, 2016
P4, N=3800, Recruiting, Sponsor: The George Institute
Trial primary completion date: Sep 2016 --> Apr 2017 Trial primary completion date: Jun 2016 --> Dec 2016
- Trial primary completion date: The Cooling And Surviving Septic Shock Study (CASS) (clinicaltrials.gov) - Mar 9, 2016
P2/3, N=560, Recruiting, Sponsor: Danish Procalcitonin Study Group
Trial primary completion date: Jun 2016 --> Dec 2016 Trial primary completion date: Dec 2016 --> Oct 2017
- Enrollment change, Trial withdrawal: SEREAL: Selenium Replacement and Serum Selenium Level in Severe Sepsis and Septic Shock Patients (clinicaltrials.gov) - Mar 5, 2016
P2, N=0, Withdrawn, Sponsor: Gil Joon Suh
Trial primary completion date: Dec 2016 --> Oct 2017 N=294 --> 0 | Not yet recruiting --> Withdrawn
- Enrollment change, Trial termination: Preemptive Resuscitation for Eradication of Septic Shock (clinicaltrials.gov) - Mar 5, 2016
P=N/A, N=43, Terminated, Sponsor: Christiana Care Health Services
N=294 --> 0 | Not yet recruiting --> Withdrawn N=140 --> 43 | Active, not recruiting --> Terminated
- | Glypressin (terlipressin) / Ferring
Trial completion, Trial primary completion date: Terlipressin in Septic Shock in Cirrhosis (clinicaltrials.gov) - Feb 25, 2016
P2/3, N=72, Completed, Sponsor: Hospital Clinic of Barcelona
N=140 --> 43 | Active, not recruiting --> Terminated Recruiting --> Completed | Trial primary completion date: Oct 2009 --> Dec 2012
- Biomarker, Trial completion, Enrollment change, IO biomarker: BIONEC: Biomarkers in Patients With Flesh-eating Bacterial Infections (clinicaltrials.gov) - Feb 17, 2016
P=N/A, N=169, Completed, Sponsor: Ole Hyldegaard
Recruiting --> Completed | Trial primary completion date: Oct 2009 --> Dec 2012 Recruiting --> Completed | N=114 --> 169
- Enrollment change, Trial termination, Trial primary completion date: OFTaPLR: Optimization of Fluid Therapy in Sepsis by a Passive Leg Raising Test (clinicaltrials.gov) - Feb 9, 2016
P=N/A, N=34, Terminated, Sponsor: Karolinska Institutet
Recruiting --> Completed | N=114 --> 169 N=120 --> 34 | Recruiting --> Terminated | Trial primary completion date: Apr 2017 --> Feb 2016; The study was stopped because of futility due to unexpected low weight gain in both groups.
- Trial completion: Dynamic Changes of Tim-3 on Monocytes and Soluble Tim-3 in Patients With Sepsis (clinicaltrials.gov) - Jan 28, 2016
P=N/A, N=1, Completed, Sponsor: Chinese PLA General Hospital
N=120 --> 34 | Recruiting --> Terminated | Trial primary completion date: Apr 2017 --> Feb 2016; The study was stopped because of futility due to unexpected low weight gain in both groups. Active, not recruiting --> Completed
- Trial completion, Trial primary completion date: FC-Rev: Does the Time Between the End of Vascular Filling and Evaluation of Its Effectiveness Modify Fluid Challenge Results in Septic Shock? (clinicaltrials.gov) - Jan 21, 2016
P=N/A, N=145, Completed, Sponsor: Centre Hospitalier Universitaire de Nīmes
Active, not recruiting --> Completed Recruiting --> Completed | Trial primary completion date: May 2016 --> Jan 2016
- ||| Trial completion, Enrollment change: SAPS: Safety and Efficacy of Procalcitonin Guided Antibiotic Therapy in Adult Intensive Care Units (ICU's) (clinicaltrials.gov) - Jan 7, 2016
P=N/A, N=1575, Completed, Sponsor: VU University Medical Center
Recruiting --> Completed | Trial primary completion date: May 2016 --> Jan 2016 Active, not recruiting --> Completed | N=2246 --> 1575
- Trial completion, Trial primary completion date: MUSCLE: Musculoskeletal Ultrasound Study in Critical Care: Longitudinal Evaluation (clinicaltrials.gov) - Dec 19, 2015
P=N/A, N=63, Completed, Sponsor: University College, London
Active, not recruiting --> Completed | N=2246 --> 1575 Recruiting --> Completed | Trial primary completion date: Feb 2018 --> Dec 2015
- Trial completion, Trial primary completion date: Administration of Human Protein C Concentrates in Patients With Sepsis and Septic Shock. (clinicaltrials.gov) - Dec 5, 2015
P2, N=60, Completed, Sponsor: University of Roma La Sapienza
Recruiting --> Completed | Trial primary completion date: Feb 2018 --> Dec 2015 Recruiting --> Completed | Trial primary completion date: Sep 2014 --> Feb 2015
- Trial completion, Trial primary completion date: CLASSIC: Conservative vs. Liberal Approach to Fluid Therapy of Septic Shock in Intensive Care (clinicaltrials.gov) - Dec 4, 2015
P4, N=153, Completed, Sponsor: Anders Perner
Recruiting --> Completed | Trial primary completion date: Sep 2014 --> Feb 2015 Recruiting --> Completed | Trial primary completion date: Aug 2015 --> Nov 2015
- Trial primary completion date: Adsorbtion of Cytokines Early in Septic Shock: the ACESS Study (clinicaltrials.gov) - Nov 24, 2015
P=N/A, N=20, Recruiting, Sponsor: Domonkos Trásy
Recruiting --> Completed | Trial primary completion date: Aug 2015 --> Nov 2015 Trial primary completion date: Oct 2015 --> Dec 2016
- ||| Gohibic (vilobelimab) / Staidson Biopharma, InflaRx
Enrollment closed, Trial primary completion date: SCIENS: Studying Complement Inhibition in Early, Newly Developing Septic Organ Dysfunction (clinicaltrials.gov) - Nov 22, 2015
P2, N=72, Active, not recruiting, Sponsor: InflaRx GmbH
Trial primary completion date: Oct 2015 --> Dec 2016 Recruiting --> Active, not recruiting | Trial primary completion date: Aug 2015 --> Dec 2015
- dexmedetomidine / Generic mfg.
Clinical: Dexmedetomidine on Microcirculation in Septic Shock (clinicaltrials.gov) - Nov 19, 2015
P4, N=30, Recruiting, Sponsor: Southeast University, China
Recruiting --> Active, not recruiting | Trial primary completion date: Aug 2015 --> Dec 2015 Completed --> Recruiting | Trial primary completion date: Apr 2015 --> Apr 2016
- ||||| Enrollment change: EUPHRATES: Safety and Efficacy of Polymyxin B Hemoperfusion (PMX) for Septic Shock (clinicaltrials.gov) - Nov 17, 2015
P3, N=478, Recruiting, Sponsor: Spectral Diagnostics (US) Inc.
Completed --> Recruiting | Trial primary completion date: Apr 2015 --> Apr 2016 N=650 --> 478
- || Trial primary completion date: Antibiotic Administration and Blood Culture Positivity in Severe Sepsis and Septic Shock (clinicaltrials.gov) - Nov 17, 2015
P=N/A, N=361, Recruiting, Sponsor: University of British Columbia
N=650 --> 478 Trial primary completion date: Dec 2015 --> Jun 2017
- Trial termination: EARTH-ICU: Early Physical Therapy in Patients With Sepsis (clinicaltrials.gov) - Nov 17, 2015
P=N/A, N=29, Terminated, Sponsor: Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Trial primary completion date: Dec 2015 --> Jun 2017 Recruiting --> Terminated
- Trial primary completion date: Endothelium in Severe Sepsis (clinicaltrials.gov) - Nov 16, 2015
P=N/A, N=600, Recruiting, Sponsor: Beth Israel Deaconess Medical Center
Recruiting --> Terminated Trial primary completion date: Jan 2012 --> Jan 2017
- | Trial completion, Trial primary completion date: ALBIOS: Volume Replacement With Albumin in Severe Sepsis (clinicaltrials.gov) - Nov 12, 2015
P3, N=1818, Completed, Sponsor: Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Trial primary completion date: Jan 2012 --> Jan 2017 Active, not recruiting --> Completed | Trial primary completion date: May 2012 --> Apr 2013
- ||| Biomarker, Enrollment open, Immune cell: Immune Failure in Critical Therapy (INFECT) Study (clinicaltrials.gov) - Nov 11, 2015
P=N/A, N=220, Recruiting, Sponsor: University of Edinburgh
Active, not recruiting --> Completed | Trial primary completion date: May 2012 --> Apr 2013 Not yet recruiting --> Recruiting
- Trial primary completion date: FC-Rev: Does the Time Between the End of Vascular Filling and Evaluation of Its Effectiveness Modify Fluid Challenge Results in Septic Shock? (clinicaltrials.gov) - Oct 23, 2015
P=N/A, N=145, Recruiting, Sponsor: Centre Hospitalier Universitaire de Nīmes
Not yet recruiting --> Recruiting Trial primary completion date: May 2015 --> May 2016
- | Enrollment open: Balanced Salt Solution VS. Normal Saline Solution in Septic Shock (clinicaltrials.gov) - Oct 23, 2015
P3, N=60, Recruiting, Sponsor: Ramathibodi Hospital
Trial primary completion date: May 2015 --> May 2016 Active, not recruiting --> Recruiting
- Biomarker, Trial primary completion date, IO biomarker: BIONEC: Biomarkers in Patients With Flesh-eating Bacterial Infections (clinicaltrials.gov) - Oct 22, 2015
P=N/A, N=114, Recruiting, Sponsor: Ole Hyldegaard
Active, not recruiting --> Recruiting Trial primary completion date: Jul 2015 --> Feb 2016
- Enrollment change, Trial termination, Trial primary completion date: Studies of Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (clinicaltrials.gov) - Oct 6, 2015
P1, N=28, Terminated, Sponsor: Northern State Medical University
Trial primary completion date: Jul 2015 --> Feb 2016 N=40 --> 28 | Active, not recruiting --> Terminated | Trial primary completion date: Dec 2012 --> Sep 2014; Inability to recruit the patients due to the short supply and changed local hospital protocol
- Enrollment open, Trial initiation date, Trial primary completion date: ASSET - a Double-Blind, Randomized Placebo-Controlled Clinical Investigation With Alteco (clinicaltrials.gov) - Sep 25, 2015
P=N/A, N=32, Recruiting, Sponsor: Alteco Medical AB
N=40 --> 28 | Active, not recruiting --> Terminated | Trial primary completion date: Dec 2012 --> Sep 2014; Inability to recruit the patients due to the short supply and changed local hospital protocol Not yet recruiting --> Recruiting | Initiation date: Mar 2015 --> Sep 2015 | Trial primary completion date: Apr 2016 --> Sep 2016
- Trial completion, Trial primary completion date: German Lactat Clearance in Severe Sepsis (clinicaltrials.gov) - Sep 25, 2015
P=N/A, N=300, Completed, Sponsor: RWTH Aachen University
Not yet recruiting --> Recruiting | Initiation date: Mar 2015 --> Sep 2015 | Trial primary completion date: Apr 2016 --> Sep 2016 Recruiting --> Completed | Trial primary completion date: Jan 2014 --> Apr 2015
- Biomarker, Trial completion, Enrollment change: Hypoxia Inducible Factor 1 Alpha as a Novel Biomarker in Septic Shock (clinicaltrials.gov) - Sep 18, 2015
P=N/A, N=63, Completed, Sponsor: University of Florida
Recruiting --> Completed | Trial primary completion date: Jan 2014 --> Apr 2015 Recruiting --> Completed | N=130 --> 63
- piperacillin sodium/tazobactam sodium / Generic mfg.
Trial termination: Standard Vs Adjusted Dosing of Piperacillin/Tazobactam in Acute Renal Failure and Septic Shock (clinicaltrials.gov) - Sep 15, 2015
P4, N=20, Terminated, Sponsor: Fraser Health
Recruiting --> Completed | N=130 --> 63 Suspended --> Terminated; Study stopped because of study personel movement to another institution.
- Enrollment open, Trial primary completion date: Epidemiology, Acute Management, and Outcomes of Patients With Sepsis Presenting to a Referral Hospital in Western Kenya (clinicaltrials.gov) - Sep 14, 2015
P=N/A, N=440, Recruiting, Sponsor: Duke University
Suspended --> Terminated; Study stopped because of study personel movement to another institution. Not yet recruiting --> Recruiting | Trial primary completion date: Jun 2015 --> Mar 2016
- Enrollment closed, Trial primary completion date: Near Infrared Spectroscopy (St02) (clinicaltrials.gov) - Sep 10, 2015
P=N/A, N=300, Active, not recruiting, Sponsor: Beth Israel Deaconess Medical Center
Not yet recruiting --> Recruiting | Trial primary completion date: Jun 2015 --> Mar 2016 Recruiting --> Active, not recruiting | Trial primary completion date: Sep 2010 --> Sep 2016
- Trial completion: VaCoSS: Serial Vasopressin and Copeptin Levels in Children With Sepsis and Septic Shock (clinicaltrials.gov) - Sep 10, 2015
P=N/A, N=136, Completed, Sponsor: Jan Hau Lee
Recruiting --> Active, not recruiting | Trial primary completion date: Sep 2010 --> Sep 2016 Recruiting --> Completed
- simvastatin / Generic mfg.
Trial completion, Enrollment change, Trial primary completion date: Statin Therapy in the Treatment of Sepsis (clinicaltrials.gov) - Sep 9, 2015
P2/3, N=13, Completed, Sponsor: Beth Israel Deaconess Medical Center
Recruiting --> Completed Recruiting --> Completed | N=60 --> 13 | Trial primary completion date: Dec 2013 --> Dec 2010
- Trial completion: Thiamine as a Metabolic Resuscitator in Septic Shock (clinicaltrials.gov) - Sep 8, 2015
P1/2, N=80, Completed, Sponsor: Beth Israel Deaconess Medical Center
Recruiting --> Completed | N=60 --> 13 | Trial primary completion date: Dec 2013 --> Dec 2010 Recruiting --> Completed
- ||| Trial completion, Enrollment change: IMproved PREdiction of Severe Sepsis in the Emergency Department (clinicaltrials.gov) - Sep 3, 2015
P=N/A, N=759, Completed, Sponsor: Axis Shield Diagnostics Ltd
Recruiting --> Completed Active, not recruiting --> Completed | N=1000 --> 759
- Enrollment change: HICOSS: High Cut-Off Continuous Veno-venous Hemodialysis (CVVHD) in Patients Treated for Acute Renal Failure After Systemic Inflammatory Response Syndrome (SIRS)/Septic Shock (clinicaltrials.gov) - Aug 26, 2015
P=N/A, N=80, Terminated, Sponsor: Gambro Dialysatoren GmbH
Active, not recruiting --> Completed | N=1000 --> 759 N=120 --> 80
- | fludrocortisone / Generic mfg., hydrocortisone / Generic mfg.
Trial completion, Trial primary completion date: APROCCHS: Activated Protein C and Corticosteroids for Human Septic Shock (clinicaltrials.gov) - Aug 12, 2015
P3, N=1241, Completed, Sponsor: University of Versailles
N=120 --> 80 Recruiting --> Completed | Trial primary completion date: Dec 2014 --> Jun 2015
- Enrollment change, Trial termination, Trial primary completion date: Comparison of a Tissue Perfusion Guided Hemodynamic Protocol With a Standard Hemodynamic Protocol in Septic Shock Patients (clinicaltrials.gov) - Aug 12, 2015
P=N/A, N=40, Terminated, Sponsor: University Hospital Inselspital, Berne
Recruiting --> Completed | Trial primary completion date: Dec 2014 --> Jun 2015 N=128 --> 40 | Active, not recruiting --> Terminated | Trial primary completion date: Aug 2013 --> Apr 2013; Problems implementing the trial
- esmolol / Generic mfg.
Trial completion, Trial primary completion date: Echocardiographic and Arterial Pressure Waveform Changes After Reducing Heart Rate With Esmolol in Septic Shock Patients (clinicaltrials.gov) - Aug 11, 2015
P=N/A, N=45, Completed, Sponsor: University of Roma La Sapienza
N=128 --> 40 | Active, not recruiting --> Terminated | Trial primary completion date: Aug 2013 --> Apr 2013; Problems implementing the trial Recruiting --> Completed | Trial primary completion date: Nov 2014 --> Jun 2014
- | Trial completion: rTSST-1 Variant Vaccine Phase 1 (clinicaltrials.gov) - Jul 25, 2015
P1, N=46, Completed, Sponsor: Biomedizinische Forschungs gmbH
Recruiting --> Completed | Trial primary completion date: Nov 2014 --> Jun 2014 Recruiting --> Completed
- Enrollment closed: Preemptive Resuscitation for Eradication of Septic Shock (clinicaltrials.gov) - Jul 17, 2015
P=N/A, N=140, Active, not recruiting, Sponsor: Christiana Care Health Services
Recruiting --> Completed Recruiting --> Active, not recruiting