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23 Companies |
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18 Products |
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18 Products |
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25 Mechanisms of Action |
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0 Trials |
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307 News |
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- | Trial completion: Antibiotic Administration and Blood Culture Positivity in Severe Sepsis and Septic Shock (clinicaltrials.gov) - Apr 20, 2019
P=N/A, N=330, Completed, Sponsor: University of British Columbia
Active, not recruiting --> Completed
- | dexmedetomidine / Generic mfg.
Enrollment change, Trial completion date, Trial termination: The Effect of Dexmedetomidine on Microcirculation in Severe Sepsis (clinicaltrials.gov) - Mar 4, 2019
P4, N=12, Terminated, Sponsor: National Taiwan University Hospital
Active, not recruiting --> Completed N=60 --> 12 | Trial completion date: Dec 2018 --> Feb 2018 | Recruiting --> Terminated
- | dexmedetomidine / Generic mfg.
Enrollment change, Trial completion date, Trial primary completion date: Dexmedetomidine on Microcirculation in Septic Shock (clinicaltrials.gov) - Dec 12, 2018
P4, N=44, Completed, Sponsor: Southeast University, China
N=60 --> 12 | Trial completion date: Dec 2018 --> Feb 2018 | Recruiting --> Terminated N=30 --> 44 | Trial completion date: May 2016 --> May 2017 | Trial primary completion date: Apr 2016 --> Dec 2016
- | Enrollment closed: Antibiotic Administration and Blood Culture Positivity in Severe Sepsis and Septic Shock (clinicaltrials.gov) - Nov 20, 2018
P=N/A, N=330, Active, not recruiting, Sponsor: University of British Columbia
N=30 --> 44 | Trial completion date: May 2016 --> May 2017 | Trial primary completion date: Apr 2016 --> Dec 2016 Recruiting --> Active, not recruiting
- | Trial primary completion date: Antibiotic Administration and Blood Culture Positivity in Severe Sepsis and Septic Shock (clinicaltrials.gov) - Oct 16, 2018
P=N/A, N=328, Recruiting, Sponsor: University of British Columbia
Recruiting --> Active, not recruiting Trial primary completion date: Jun 2018 --> Dec 2018
- | Trial completion, Phase classification: HEMOSEPSIS: Transpulmonary Thermodilution and Transesophageal Echocardiography in Early Septic Shock (clinicaltrials.gov) - Aug 22, 2018
P4, N=153, Completed, Sponsor: University Hospital, Limoges
Trial primary completion date: Jun 2018 --> Dec 2018 Recruiting --> Completed | Phase classification: P3 --> P4
- | Neo-Synephrine (phenylephrine hydrochloride ophthalmic solution) / Paragon BioTeck, Bausch Health, Akorn
Enrollment change, Trial termination: Phenylephrine Versus Norepinephrine for Septic Shock in Critically Ill Patients (clinicaltrials.gov) - Jun 13, 2018
P4, N=17, Terminated, Sponsor: Vanderbilt University Medical Center
Recruiting --> Completed | Phase classification: P3 --> P4 N=75 --> 17 | Recruiting --> Terminated; Slow enrollment; Lack of support and equipoise
- | Trial completion date: Effects of Endotoxin in Normal Human Volunteers (clinicaltrials.gov) - Jun 2, 2018
P1, N=198, Completed, Sponsor: National Institutes of Health Clinical Center (CC)
N=75 --> 17 | Recruiting --> Terminated; Slow enrollment; Lack of support and equipoise Trial completion date: Mar 2007 --> May 2018
- | Trial completion, Trial completion date: Lactated Ringer Versus Albumin in Early Sepsis Therapy (clinicaltrials.gov) - Apr 6, 2018
P3, N=360, Completed, Sponsor: University of Sao Paulo
Trial completion date: Mar 2007 --> May 2018 Recruiting --> Completed | Trial completion date: Dec 2016 --> Dec 2017
- | Trial completion, Phase classification: Adsorbtion of Cytokines Early in Septic Shock: the ACESS Study (clinicaltrials.gov) - Mar 27, 2018
P, N=20, Completed, Sponsor: Zsolt Molnár, MD, PhD, DEAA
Recruiting --> Completed | Trial completion date: Dec 2016 --> Dec 2017 Recruiting --> Completed | Phase classification: PN/A --> P
- | Trial completion date, Trial termination, Trial primary completion date: The Effect of Erythropietin on Microcircualtory Alteration in Intensive Care Unit Patients With Severe Sepsis (clinicaltrials.gov) - Mar 14, 2018
P=N/A, N=22, Terminated, Sponsor: London Health Sciences Centre
Recruiting --> Completed | Phase classification: PN/A --> P Trial completion date: Sep 2017 --> Mar 2018 | Recruiting --> Terminated | Trial primary completion date: Sep 2017 --> Mar 2018; Lack of recruitment
- | Trial completion: Epidemiology, Acute Management, and Outcomes of Patients With Sepsis Presenting to a Referral Hospital in Western Kenya (clinicaltrials.gov) - Jan 5, 2018
P=N/A, N=198, Completed, Sponsor: Duke University
Trial completion date: Sep 2017 --> Mar 2018 | Recruiting --> Terminated | Trial primary completion date: Sep 2017 --> Mar 2018; Lack of recruitment Active, not recruiting --> Completed
- | Trial completion: CENSER: Early Use of Norepinephrine in Septic Shock Resuscitation (clinicaltrials.gov) - Dec 22, 2017
P=N/A, N=310, Completed, Sponsor: Mahidol University
Active, not recruiting --> Completed Recruiting --> Completed
- | Enrollment change, Trial initiation date, Trial primary completion date: Effect of Different Strategies for Titrating a High MAP on Microcirculation (clinicaltrials.gov) - Dec 14, 2017
P4, N=24, Completed, Sponsor: Southeast University, China
Recruiting --> Completed N=20 --> 24 | Initiation date: Sep 2011 --> Mar 2014 | Trial primary completion date: Dec 2014 --> Sep 2016
- | Solu-Cortef (hydrocortisone sodium succinate injection) / Pfizer
Trial completion: ADRENAL: ADjunctive coRticosteroid trEatment iN criticAlly ilL Patients With Septic Shock (clinicaltrials.gov) - Dec 12, 2017
P4, N=3800, Completed, Sponsor: The George Institute
N=20 --> 24 | Initiation date: Sep 2011 --> Mar 2014 | Trial primary completion date: Dec 2014 --> Sep 2016 Active, not recruiting --> Completed
- ||| Trial completion, Phase classification: EUPHRATES: Safety and Efficacy of Polymyxin B Hemoperfusion (PMX) for Septic Shock (clinicaltrials.gov) - Dec 5, 2017
P=N/A, N=450, Completed, Sponsor: Spectral Diagnostics (US) Inc.
Active, not recruiting --> Completed Active, not recruiting --> Completed | Phase classification: P3 --> PN/A
- | Trial completion: Effects of Endotoxin in Normal Human Volunteers (clinicaltrials.gov) - Oct 18, 2017
P1, N=198, Completed, Sponsor: National Institutes of Health Clinical Center (CC)
Active, not recruiting --> Completed | Phase classification: P3 --> PN/A Active, not recruiting --> Completed
- | Trial initiation date: Antibiotic Administration and Blood Culture Positivity in Severe Sepsis and Septic Shock (clinicaltrials.gov) - Oct 16, 2017
P=N/A, N=328, Recruiting, Sponsor: University of British Columbia
Active, not recruiting --> Completed Initiation date: Jun 2013 --> Mar 2014
- | Solu-Cortef (hydrocortisone sodium succinate injection) / Pfizer
Trial completion, Trial primary completion date: Hyperglycemia and Effects of Daily 100 mg Versus 200 mg of Hydrocortisone Therapy in Patients With Septic Shock (clinicaltrials.gov) - Oct 6, 2017
P4, N=80, Completed, Sponsor: Srinakharinwirot University
Initiation date: Jun 2013 --> Mar 2014 Recruiting --> Completed | Trial primary completion date: Dec 2016 --> May 2017
- | Trial completion, Enrollment change: Preemptive Resuscitation for Eradication of Septic Shock (clinicaltrials.gov) - Oct 4, 2017
P=N/A, N=142, Completed, Sponsor: Christiana Care Health Services
Recruiting --> Completed | Trial primary completion date: Dec 2016 --> May 2017 Terminated --> Completed | N=43 --> 142
- | Actimmune (interferon gamma-1 b) / Clinigen, Amgen
Trial completion, Enrollment change, IO biomarker: The Effects of Interferon-gamma on Sepsis-induced Immunoparalysis (clinicaltrials.gov) - Sep 29, 2017
P3, N=4, Completed, Sponsor: Radboud University
Terminated --> Completed | N=43 --> 142 Recruiting --> Completed | N=20 --> 4
- | Solu-Cortef (hydrocortisone sodium succinate injection) / Pfizer
Trial primary completion date: ADRENAL: ADjunctive coRticosteroid trEatment iN criticAlly ilL Patients With Septic Shock (clinicaltrials.gov) - Sep 7, 2017
P4, N=3800, Active, not recruiting, Sponsor: The George Institute
Recruiting --> Completed | N=20 --> 4 Trial primary completion date: Jul 2017 --> Oct 2017
- | Trial primary completion date: Evaluation of Intestinal Brush Border Enzyme Function in Critically Ill Patients (clinicaltrials.gov) - Aug 29, 2017
P=N/A, N=39, Completed, Sponsor: Medical University of Vienna
Trial primary completion date: Jul 2017 --> Oct 2017 Trial primary completion date: Oct 2014 --> Feb 2015
- | Trial completion: Effect of APC and Epo on the Inflammatory Response During Sepsis (clinicaltrials.gov) - Aug 25, 2017
P=N/A, N=40, Completed, Sponsor: Lawson Health Research Institute
Trial primary completion date: Oct 2014 --> Feb 2015 Recruiting --> Completed
- | Trial completion: ADSeS: Examination of ADMA Serum Level and DDAH II (clinicaltrials.gov) - Aug 3, 2017
P=N/A, N=120, Completed, Sponsor: Universitätsklinikum Hamburg-Eppendorf
Recruiting --> Completed Active, not recruiting --> Completed
- | clonidine / Generic mfg.
Trial primary completion date: CATACHOC: Upregulation of Alpha-1 Receptors Upon Septic Shock? (clinicaltrials.gov) - Jul 28, 2017
P2/3, N=40, Terminated, Sponsor: Direction Centrale du Service de Santé des Armées
Active, not recruiting --> Completed Trial primary completion date: Aug 2014 --> Aug 2013
- | Phase classification: High MAP in Septic Shock With Hypertension (clinicaltrials.gov) - Jul 6, 2017
P=N/A, N=19, Completed, Sponsor: Southeast University, China
Trial primary completion date: Aug 2014 --> Aug 2013 Phase classification: P4 --> P=N/A
- Enrollment change, Trial termination: ASSET - a Double-Blind, Randomized Placebo-Controlled Clinical Investigation With Alteco (clinicaltrials.gov) - Jun 28, 2017
P=N/A, N=15, Terminated, Sponsor: Alteco Medical AB
Phase classification: P4 --> P=N/A N=32 --> 15 | Recruiting --> Terminated; Problem to find eligible patients to include
- | ceftriaxone / Generic mfg.
Trial completion, Enrollment change, Trial primary completion date: PHANTASi: Prehospital Antibiotics Against Sepsis Trial (clinicaltrials.gov) - Jun 15, 2017
P=N/A, N=2672, Completed, Sponsor: VU University Medical Center
N=32 --> 15 | Recruiting --> Terminated; Problem to find eligible patients to include Recruiting --> Completed | N=2200 --> 2672 | Trial primary completion date: Jun 2016 --> Jun 2017
- | simvastatin / Generic mfg.
Enrollment change: Statin Therapy in the Treatment of Sepsis (clinicaltrials.gov) - Jun 14, 2017
P2/3, N=18, Completed, Sponsor: Beth Israel Deaconess Medical Center
Recruiting --> Completed | N=2200 --> 2672 | Trial primary completion date: Jun 2016 --> Jun 2017 N=13 --> 18
- | dexmedetomidine / Generic mfg.
Clinical: Dexmedetomidine on Microcirculation in Septic Shock (clinicaltrials.gov) - May 17, 2017
P4, N=30, Completed, Sponsor: Southeast University, China
N=13 --> 18 Recruiting --> Completed
- | Solu-Cortef (hydrocortisone sodium succinate injection) / Pfizer
Enrollment closed, Trial primary completion date: ADRENAL: ADjunctive coRticosteroid trEatment iN criticAlly ilL Patients With Septic Shock (clinicaltrials.gov) - May 3, 2017
P4, N=3800, Active, not recruiting, Sponsor: The George Institute
Recruiting --> Completed Recruiting --> Active, not recruiting | Trial primary completion date: Dec 2016 --> Jul 2017
- ||| Trial completion, Enrollment change, Trial initiation date, Trial primary completion date: Near Infrared Spectroscopy (St02) (clinicaltrials.gov) - Apr 26, 2017
P=N/A, N=186, Completed, Sponsor: Beth Israel Deaconess Medical Center
Recruiting --> Active, not recruiting | Trial primary completion date: Dec 2016 --> Jul 2017 Active, not recruiting --> Completed | N=300 --> 186 | Initiation date: Sep 2008 --> Jan 2009 | Trial primary completion date: Sep 2016 --> Jan 2010
- | Trial completion, Enrollment change, Trial initiation date, Trial primary completion date: Endothelium in Severe Sepsis (clinicaltrials.gov) - Apr 26, 2017
P=N/A, N=910, Completed, Sponsor: Beth Israel Deaconess Medical Center
Active, not recruiting --> Completed | N=300 --> 186 | Initiation date: Sep 2008 --> Jan 2009 | Trial primary completion date: Sep 2016 --> Jan 2010 Recruiting --> Completed | N=600 --> 910 | Initiation date: Jun 2008 --> Mar 2008 | Trial primary completion date: Jan 2017 --> May 2013
- | Trial completion: Balanced Salt Solution VS. Normal Saline Solution in Septic Shock (clinicaltrials.gov) - Apr 26, 2017
P3, N=60, Completed, Sponsor: Ramathibodi Hospital
Recruiting --> Completed | N=600 --> 910 | Initiation date: Jun 2008 --> Mar 2008 | Trial primary completion date: Jan 2017 --> May 2013 Recruiting --> Completed
- | Ventavis (iloprost) / Bayer, J&J, University of Copenhagen, Integrilin (eptifibatide) / Takeda
Trial completion, Trial primary completion date: CO-ILEPSS: Co-administration of Iloprost and Eptifibatide in Septic Shock Patients (clinicaltrials.gov) - Apr 24, 2017
P2, N=18, Completed, Sponsor: Sisse R. Ostrowski, MD PhD DMSc
Recruiting --> Completed Recruiting --> Completed | Trial primary completion date: Aug 2015 --> Aug 2016
- | Phase classification: Evaluation of Hemodynamic Effects of Cascade Hemofiltration in Septic Shock (clinicaltrials.gov) - Apr 7, 2017
P=N/A, N=60, Completed, Sponsor: Baxter Healthcare Corporation
Recruiting --> Completed | Trial primary completion date: Aug 2015 --> Aug 2016 Phase classification: P3 --> P=N/A
- | Trial primary completion date: Adsorbtion of Cytokines Early in Septic Shock: the ACESS Study (clinicaltrials.gov) - Mar 9, 2017
P=N/A, N=20, Recruiting, Sponsor: Domonkos Trásy
Phase classification: P3 --> P=N/A Trial primary completion date: Dec 2016 --> Dec 2017
- Enrollment change, Trial termination: IDEAL-ICU: I.D.E.A.L.-I.C.U. (Initiation of Dialysis EArly Versus deLayed in Intensive Care Unit) (clinicaltrials.gov) - Feb 2, 2017
P3, N=500, Terminated, Sponsor: Centre Hospitalier Universitaire Dijon
Trial primary completion date: Dec 2016 --> Dec 2017 N=864 --> 500 | Recruiting --> Terminated
- Trial completion: The Effect of Three Different Fluids(Albumin 5%, Normal Saline, Hydroxyethyl Starch 130 kD) on Microcirculation in Severe Sepsis/Septic Shock Patients (clinicaltrials.gov) - Jan 26, 2017
P=N/A, N=45, Completed, Sponsor: Mercy Research
N=864 --> 500 | Recruiting --> Terminated Not yet recruiting --> Completed
- midazolam hydrochloride / Generic mfg., dexmedetomidine / Generic mfg.
Clinical: The Effect of Dexmedetomidine on Microcirculation in Severe Sepsis (clinicaltrials.gov) - Dec 21, 2016
P4, N=60, Recruiting, Sponsor: National Taiwan University Hospital
Not yet recruiting --> Completed Trial primary completion date: Jun 2017 --> Jun 2018
- Enrollment change, Trial termination: Cerebral Oxygenation in Septic Patients Using Vasopressors - the Conscious Study (clinicaltrials.gov) - Dec 14, 2016
P=N/A, N=15, Terminated, Sponsor: Karl-Andre Wian
Trial primary completion date: Jun 2017 --> Jun 2018 N=40 --> 15 | Recruiting --> Terminated; Too slow recruitment.
- Enrollment closed, Enrollment change: Epidemiology, Acute Management, and Outcomes of Patients With Sepsis Presenting to a Referral Hospital in Western Kenya (clinicaltrials.gov) - Dec 2, 2016
P=N/A, N=198, Active, not recruiting, Sponsor: Duke University
N=40 --> 15 | Recruiting --> Terminated; Too slow recruitment. Recruiting --> Active, not recruiting | N=440 --> 198
- Enrollment change, Trial termination, Trial primary completion date: The Cooling And Surviving Septic Shock Study (CASS) (clinicaltrials.gov) - Nov 23, 2016
P2/3, N=433, Terminated, Sponsor: Danish Procalcitonin Study Group
Recruiting --> Active, not recruiting | N=440 --> 198 N=560 --> 433 | Recruiting --> Terminated | Trial primary completion date: Oct 2017 --> Nov 2016; Futility
- || Trial primary completion date: Antibiotic Administration and Blood Culture Positivity in Severe Sepsis and Septic Shock (clinicaltrials.gov) - Nov 4, 2016
P=N/A, N=361, Recruiting, Sponsor: University of British Columbia
N=560 --> 433 | Recruiting --> Terminated | Trial primary completion date: Oct 2017 --> Nov 2016; Futility Trial primary completion date: Jun 2017 --> Jun 2018
- ||| Biomarker, Trial completion, Enrollment change, Immune cell: Immune Failure in Critical Therapy (INFECT) Study (clinicaltrials.gov) - Oct 26, 2016
P=N/A, N=168, Completed, Sponsor: University of Edinburgh
Trial primary completion date: Jun 2017 --> Jun 2018 Recruiting --> Completed | N=220 --> 168
- Solu-Cortef (hydrocortisone sodium succinate injection) / Pfizer
Trial primary completion date: Hyperglycemia and Effects of Daily 100 mg Versus 200 mg of Hydrocortisone Therapy in Patients With Septic Shock (clinicaltrials.gov) - Sep 16, 2016
P4, N=80, Recruiting, Sponsor: Srinakharinwirot University
Recruiting --> Completed | N=220 --> 168 Trial primary completion date: Jun 2016 --> Dec 2016
- | Trial completion, Trial primary completion date: Pilot Study for the SQUEEZE Trial (clinicaltrials.gov) - Aug 19, 2016
P3, N=53, Completed, Sponsor: McMaster Children's Hospital
Trial primary completion date: Jun 2016 --> Dec 2016 Recruiting --> Completed | Trial primary completion date: Jul 2015 --> Jun 2016
- Trial primary completion date: Lactated Ringer Versus Albumin in Early Sepsis Therapy (clinicaltrials.gov) - Aug 9, 2016
P3, N=360, Recruiting, Sponsor: University of Sao Paulo
Recruiting --> Completed | Trial primary completion date: Jul 2015 --> Jun 2016 Trial primary completion date: Apr 2014 --> Oct 2016
- Trial completion: ARDS Prediction Score in Critically Ill Patients in China (clinicaltrials.gov) - Jun 28, 2016
P=N/A, N=698, Completed, Sponsor: Jianfeng Xie
Trial primary completion date: Apr 2014 --> Oct 2016 Recruiting --> Completed