- |||||||||| dexmedetomidine / Generic mfg.
Enrollment change, Trial completion date, Trial termination: The Effect of Dexmedetomidine on Microcirculation in Severe Sepsis (clinicaltrials.gov) - Mar 4, 2019 P4, N=12, Terminated, Active, not recruiting --> Completed N=60 --> 12 | Trial completion date: Dec 2018 --> Feb 2018 | Recruiting --> Terminated
- |||||||||| dexmedetomidine / Generic mfg.
Enrollment change, Trial completion date, Trial primary completion date: Dexmedetomidine on Microcirculation in Septic Shock (clinicaltrials.gov) - Dec 12, 2018 P4, N=44, Completed, N=60 --> 12 | Trial completion date: Dec 2018 --> Feb 2018 | Recruiting --> Terminated N=30 --> 44 | Trial completion date: May 2016 --> May 2017 | Trial primary completion date: Apr 2016 --> Dec 2016
- |||||||||| Neo-Synephrine (phenylephrine hydrochloride ophthalmic solution) / Paragon BioTeck, Bausch Health, Akorn
Enrollment change, Trial termination: Phenylephrine Versus Norepinephrine for Septic Shock in Critically Ill Patients (clinicaltrials.gov) - Jun 13, 2018 P4, N=17, Terminated, Recruiting --> Completed | Phase classification: P3 --> P4 N=75 --> 17 | Recruiting --> Terminated; Slow enrollment; Lack of support and equipoise
- |||||||||| Trial completion date: Effects of Endotoxin in Normal Human Volunteers (clinicaltrials.gov) - Jun 2, 2018
P1, N=198, Completed, N=75 --> 17 | Recruiting --> Terminated; Slow enrollment; Lack of support and equipoise Trial completion date: Mar 2007 --> May 2018
- |||||||||| Trial completion, Trial completion date: Lactated Ringer Versus Albumin in Early Sepsis Therapy (clinicaltrials.gov) - Apr 6, 2018
P3, N=360, Completed, Trial completion date: Mar 2007 --> May 2018 Recruiting --> Completed | Trial completion date: Dec 2016 --> Dec 2017
- |||||||||| Trial completion: Effects of Endotoxin in Normal Human Volunteers (clinicaltrials.gov) - Oct 18, 2017
P1, N=198, Completed, Active, not recruiting --> Completed | Phase classification: P3 --> PN/A Active, not recruiting --> Completed
- |||||||||| Trial completion, Enrollment change: Preemptive Resuscitation for Eradication of Septic Shock (clinicaltrials.gov) - Oct 4, 2017
P=N/A, N=142, Completed, Recruiting --> Completed | Trial primary completion date: Dec 2016 --> May 2017 Terminated --> Completed | N=43 --> 142
- |||||||||| Phase classification: High MAP in Septic Shock With Hypertension (clinicaltrials.gov) - Jul 6, 2017
P=N/A, N=19, Completed, Trial primary completion date: Aug 2014 --> Aug 2013 Phase classification: P4 --> P=N/A
- |||||||||| ceftriaxone / Generic mfg.
Trial completion, Enrollment change, Trial primary completion date: PHANTASi: Prehospital Antibiotics Against Sepsis Trial (clinicaltrials.gov) - Jun 15, 2017 P=N/A, N=2672, Completed, N=32 --> 15 | Recruiting --> Terminated; Problem to find eligible patients to include Recruiting --> Completed | N=2200 --> 2672 | Trial primary completion date: Jun 2016 --> Jun 2017
- |||||||||| simvastatin / Generic mfg.
Enrollment change: Statin Therapy in the Treatment of Sepsis (clinicaltrials.gov) - Jun 14, 2017 P2/3, N=18, Completed, Recruiting --> Completed | N=2200 --> 2672 | Trial primary completion date: Jun 2016 --> Jun 2017 N=13 --> 18
- |||||||||| Trial completion, Enrollment change, Trial initiation date, Trial primary completion date: Near Infrared Spectroscopy (St02) (clinicaltrials.gov) - Apr 26, 2017
P=N/A, N=186, Completed, Recruiting --> Active, not recruiting | Trial primary completion date: Dec 2016 --> Jul 2017 Active, not recruiting --> Completed | N=300 --> 186 | Initiation date: Sep 2008 --> Jan 2009 | Trial primary completion date: Sep 2016 --> Jan 2010
- |||||||||| Trial completion, Enrollment change, Trial initiation date, Trial primary completion date: Endothelium in Severe Sepsis (clinicaltrials.gov) - Apr 26, 2017
P=N/A, N=910, Completed, Active, not recruiting --> Completed | N=300 --> 186 | Initiation date: Sep 2008 --> Jan 2009 | Trial primary completion date: Sep 2016 --> Jan 2010 Recruiting --> Completed | N=600 --> 910 | Initiation date: Jun 2008 --> Mar 2008 | Trial primary completion date: Jan 2017 --> May 2013
- |||||||||| Enrollment change, Trial termination, Trial primary completion date: The Cooling And Surviving Septic Shock Study (CASS) (clinicaltrials.gov) - Nov 23, 2016
P2/3, N=433, Terminated, Recruiting --> Active, not recruiting | N=440 --> 198 N=560 --> 433 | Recruiting --> Terminated | Trial primary completion date: Oct 2017 --> Nov 2016; Futility
- |||||||||| Biomarker, Trial completion, Enrollment change, Immune cell: Immune Failure in Critical Therapy (INFECT) Study (clinicaltrials.gov) - Oct 26, 2016
P=N/A, N=168, Completed, Trial primary completion date: Jun 2017 --> Jun 2018 Recruiting --> Completed | N=220 --> 168
- |||||||||| Trial completion, Trial primary completion date: Pilot Study for the SQUEEZE Trial (clinicaltrials.gov) - Aug 19, 2016
P3, N=53, Completed, Trial primary completion date: Jun 2016 --> Dec 2016 Recruiting --> Completed | Trial primary completion date: Jul 2015 --> Jun 2016
- |||||||||| Trial primary completion date: Lactated Ringer Versus Albumin in Early Sepsis Therapy (clinicaltrials.gov) - Aug 9, 2016
P3, N=360, Recruiting, Recruiting --> Completed | Trial primary completion date: Jul 2015 --> Jun 2016 Trial primary completion date: Apr 2014 --> Oct 2016
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