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62 Mechanisms of Action |
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- || Enrollment closed, Trial primary completion date: TailoredT: Prospective Study to Characterize Host-pathogen Related Factors in Hospitalized and ED Patients With LRTI and/or Sepsis (clinicaltrials.gov) - Mar 8, 2016
P=N/A, N=1200, Active, not recruiting, Sponsor: MeMed Diagnostics Ltd.
Recruiting --> Active, not recruiting | Trial primary completion date: Mar 2016 --> Jun 2016
- Trial completion, Trial primary completion date: VISLISI: Virulence of Staphylococcus Lugdunensis in Severe Infections (clinicaltrials.gov) - Mar 7, 2016
P=N/A, N=82, Completed, Sponsor: University Hospital, Strasbourg, France
Recruiting --> Active, not recruiting | Trial primary completion date: Mar 2016 --> Jun 2016 Recruiting --> Completed | Trial primary completion date: Sep 2018 --> Feb 2016
- Enrollment change, Trial withdrawal: SEREAL: Selenium Replacement and Serum Selenium Level in Severe Sepsis and Septic Shock Patients (clinicaltrials.gov) - Mar 5, 2016
P2, N=0, Withdrawn, Sponsor: Gil Joon Suh
Recruiting --> Completed | Trial primary completion date: Sep 2018 --> Feb 2016 N=294 --> 0 | Not yet recruiting --> Withdrawn
- Enrollment change, Trial termination: Preemptive Resuscitation for Eradication of Septic Shock (clinicaltrials.gov) - Mar 5, 2016
P=N/A, N=43, Terminated, Sponsor: Christiana Care Health Services
N=294 --> 0 | Not yet recruiting --> Withdrawn N=140 --> 43 | Active, not recruiting --> Terminated
- ||||||| vancomycin / Generic mfg., linezolid oral / Generic mfg.
Trial completion, Gram positive: Antibiotic Treatment for Infections of Short Term In-dwelling Vascular Catheters Due to Gram Positive Bacteria (clinicaltrials.gov) - Feb 27, 2016
P3, N=739, Completed, Sponsor: Pfizer
N=140 --> 43 | Active, not recruiting --> Terminated No longer recruiting --> Completed
- Trial primary completion date: Lung and Systemic Inflammation in the Critically Ill Patient (clinicaltrials.gov) - Feb 24, 2016
P=N/A, N=18, Recruiting, Sponsor: Rigshospitalet, Denmark
No longer recruiting --> Completed Trial primary completion date: Jul 2014 --> Nov 2016
- ceftriaxone / Generic mfg., moxifloxacin intravenous / Generic mfg.
Trial completion, Enrollment change, Trial primary completion date: Comparisons of Intravenous Ceftriaxone With Intravenous Moxifloxacin in ERCP (clinicaltrials.gov) - Feb 24, 2016
P2, N=86, Completed, Sponsor: Kangbuk Samsung Hospital
Trial primary completion date: Jul 2014 --> Nov 2016 Not yet recruiting --> Completed | N=160 --> 86 | Trial primary completion date: Dec 2014 --> Sep 2015
- Trial completion, Enrollment change, Trial primary completion date, IO biomarker: SEPTIFLUX2: Prognostic Interest of Leucocyte Immunophenotyping During the Acute Phase of Sepsis (clinicaltrials.gov) - Feb 24, 2016
P=N/A, N=1000, Completed, Sponsor: University Hospital, Limoges
Not yet recruiting --> Completed | N=160 --> 86 | Trial primary completion date: Dec 2014 --> Sep 2015 Recruiting --> Completed | N=237 --> 1000 | Trial primary completion date: Nov 2014 --> Jun 2015
- | Glypressin (terlipressin) / Ferring
Trial completion, Trial primary completion date: Terlipressin in Septic Shock in Cirrhosis (clinicaltrials.gov) - Feb 24, 2016
P2/3, N=72, Completed, Sponsor: Hospital Clinic of Barcelona
Recruiting --> Completed | N=237 --> 1000 | Trial primary completion date: Nov 2014 --> Jun 2015 Recruiting --> Completed | Trial primary completion date: Oct 2009 --> Dec 2012
- || Trial primary completion date: Changes in Exhaled 13CO2/12CO2 Breath Delta Value as an Early Indicator of Infection in ICU Patients (clinicaltrials.gov) - Feb 23, 2016
P2, N=110, Recruiting, Sponsor: Isomark, LLC
Recruiting --> Completed | Trial primary completion date: Oct 2009 --> Dec 2012 Trial primary completion date: Dec 2015 --> Jun 2016
- ||| Trial completion: SEA050: An Observational Study of the Causes, Management, and Outcomes of Community-acquired Sepsis and Severe Sepsis in Southeast Asia (clinicaltrials.gov) - Feb 18, 2016
P=N/A, N=2250, Completed, Sponsor: University of Oxford
Trial primary completion date: Dec 2015 --> Jun 2016 Recruiting --> Completed
- cefazolin / Generic mfg.
Enrollment closed, Enrollment change, Trial primary completion date: An Open Label Study to Describe the Pharmacokinetics of Cefazolin in Preterm Neonates (clinicaltrials.gov) - Feb 16, 2016
P1, N=9, Active, not recruiting, Sponsor: Phillip Brian Smith
Recruiting --> Completed Recruiting --> Active, not recruiting | N=12 --> 9 | Trial primary completion date: Dec 2015 --> Jul 2016
- Enrollment change, Trial termination, Trial primary completion date: OFTaPLR: Optimization of Fluid Therapy in Sepsis by a Passive Leg Raising Test (clinicaltrials.gov) - Feb 9, 2016
P=N/A, N=34, Terminated, Sponsor: Karolinska Institutet
Recruiting --> Active, not recruiting | N=12 --> 9 | Trial primary completion date: Dec 2015 --> Jul 2016 N=120 --> 34 | Recruiting --> Terminated | Trial primary completion date: Apr 2017 --> Feb 2016; The study was stopped because of futility due to unexpected low weight gain in both groups.
- |||| Cubicin (daptomycin) / Merck (MSD)
Trial completion: Safety & Efficacy of Daptomycin Versus Standard of Care (SOC) in 1 - 17 Year Olds With Staphylococcus Aureus Bacteremia (MK-3009-005) (clinicaltrials.gov) - Feb 3, 2016
P4, N=82, Completed, Sponsor: Cubist Pharmaceuticals LLC
N=120 --> 34 | Recruiting --> Terminated | Trial primary completion date: Apr 2017 --> Feb 2016; The study was stopped because of futility due to unexpected low weight gain in both groups. Active, not recruiting --> Completed
- tacrolimus intravenous / Generic mfg., mycophenolate mofetil / Generic mfg., sirolimus / Generic mfg.
Trial primary completion date: Using mTOR Inhibitors in the Prevention of BK Nephropathy (clinicaltrials.gov) - Jan 30, 2016
P=N/A, N=41, Active, not recruiting, Sponsor: Columbia University
Active, not recruiting --> Completed Trial primary completion date: Dec 2015 --> Dec 2016
- Trial primary completion date: EIDECS: End-of-life Decision-making in Patients With Sepsis-related Organ Failure (clinicaltrials.gov) - Jan 28, 2016
P=N/A, N=180, Active, not recruiting, Sponsor: Center for Sepsis Control and Care, Germany
Trial primary completion date: Dec 2015 --> Dec 2016 Trial primary completion date: Oct 2014 --> Aug 2016
- Trial completion, Enrollment change, Trial primary completion date: Biological Markers to Identify Early Sepsis and Acute Lung Injury (clinicaltrials.gov) - Jan 28, 2016
P=N/A, N=30, Completed, Sponsor: Chimei Medical Center
Trial primary completion date: Oct 2014 --> Aug 2016 Recruiting --> Completed | N=120 --> 30 | Trial primary completion date: Sep 2009 --> Aug 2011
- Trial completion: Dynamic Changes of Tim-3 on Monocytes and Soluble Tim-3 in Patients With Sepsis (clinicaltrials.gov) - Jan 28, 2016
P=N/A, N=1, Completed, Sponsor: Chinese PLA General Hospital
Recruiting --> Completed | N=120 --> 30 | Trial primary completion date: Sep 2009 --> Aug 2011 Active, not recruiting --> Completed
- Trial completion, IO biomarker: Detection Of Monocytes/Macrophages Function And Tim-3 Expression In Septic Patients (clinicaltrials.gov) - Jan 28, 2016
P=N/A, N=1, Completed, Sponsor: Chinese PLA General Hospital
Active, not recruiting --> Completed Recruiting --> Completed
- ||| Cubicin (daptomycin) / Merck (MSD)
Enrollment closed: Safety & Efficacy of Daptomycin Versus Standard of Care (SOC) in 1 - 17 Year Olds With Staphylococcus Aureus Bacteremia (MK-3009-005) (clinicaltrials.gov) - Jan 22, 2016
P4, N=75, Active, not recruiting, Sponsor: Cubist Pharmaceuticals LLC
Recruiting --> Completed Recruiting --> Active, not recruiting
- Trial completion, Trial primary completion date: FC-Rev: Does the Time Between the End of Vascular Filling and Evaluation of Its Effectiveness Modify Fluid Challenge Results in Septic Shock? (clinicaltrials.gov) - Jan 20, 2016
P=N/A, N=145, Completed, Sponsor: Centre Hospitalier Universitaire de N?mes
Recruiting --> Active, not recruiting Recruiting --> Completed | Trial primary completion date: May 2016 --> Jan 2016
- ||| Trial completion, Enrollment change: SAPS: Safety and Efficacy of Procalcitonin Guided Antibiotic Therapy in Adult Intensive Care Units (ICU's) (clinicaltrials.gov) - Jan 7, 2016
P=N/A, N=1575, Completed, Sponsor: VU University Medical Center
Recruiting --> Completed | Trial primary completion date: May 2016 --> Jan 2016 Active, not recruiting --> Completed | N=2246 --> 1575
- Trial completion: DYnAMICS: DYsphAgia In Mechanically Ventilated ICU patientS (clinicaltrials.gov) - Jan 4, 2016
P=N/A, N=2000, Completed, Sponsor: University Hospital Inselspital, Berne
Active, not recruiting --> Completed | N=2246 --> 1575 Recruiting --> Completed
- Trial completion: The Role of the Gut Microbiota in the Systemic Immune Response During Human Endotoxemia (clinicaltrials.gov) - Dec 30, 2015
P=N/A, N=16, Completed, Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Recruiting --> Completed Recruiting --> Completed
- Trial completion, Trial primary completion date: MUSCLE: Musculoskeletal Ultrasound Study in Critical Care: Longitudinal Evaluation (clinicaltrials.gov) - Dec 18, 2015
P=N/A, N=63, Completed, Sponsor: University College, London
Recruiting --> Completed Recruiting --> Completed | Trial primary completion date: Feb 2018 --> Dec 2015
- Trial primary completion date, Gram negative: Clinical Impact of Fluoroquinolone Resistance in Bacteremia Caused by Gram-Negative Bacilli of Urinary Tract Origin (clinicaltrials.gov) - Dec 17, 2015
P=N/A, N=1000, Active, not recruiting, Sponsor: University of Pittsburgh
Recruiting --> Completed | Trial primary completion date: Feb 2018 --> Dec 2015 Trial primary completion date: Dec 2015 --> Dec 2016
- piperacillin sodium/tazobactam sodium / Generic mfg.
Trial primary completion date: Piperacillin/Tazobactam for Bacteremia With Organisms Producing Chromosomally-Encoded AmpC Beta-Lactamase (clinicaltrials.gov) - Dec 17, 2015
P=N/A, N=1000, Active, not recruiting, Sponsor: University of Pittsburgh
Trial primary completion date: Dec 2015 --> Dec 2016 Trial primary completion date: Dec 2015 --> Dec 2016
- Trial completion, Enrollment change: IRAMST: Inflammatory Response After Muscle and Skeleton Trauma (clinicaltrials.gov) - Dec 17, 2015
P=N/A, N=48, Completed, Sponsor: University of Ulm
Trial primary completion date: Dec 2015 --> Dec 2016 Recruiting --> Completed | N=90 --> 48
- colistin sulphate / Generic mfg.
Trial completion, Trial primary completion date: Optimizing Dosing of Colistin for Infections Resistant to All Other Antibiotics, Approved NIH Protocol Dated 12.06.07(DMID Protocol #07-0036) (clinicaltrials.gov) - Dec 17, 2015
P=N/A, N=10, Completed, Sponsor: University of Pittsburgh
Recruiting --> Completed | N=90 --> 48 Active, not recruiting --> Completed | Trial primary completion date: Dec 2014 --> Aug 2015
- Trial completion: Improving Maternal and Child Health in India: Evaluating Demand and Supply Side Strategies (IMATCHINE) (clinicaltrials.gov) - Dec 16, 2015
P=N/A, N=14990, Completed, Sponsor: Duke University
Active, not recruiting --> Completed | Trial primary completion date: Dec 2014 --> Aug 2015 Active, not recruiting --> Completed
- Trial primary completion date: Administration of Protein C Concentrates in Adult Critically Ill Septic Patients (clinicaltrials.gov) - Dec 15, 2015
P3, N=0, Terminated, Sponsor: Universit
Active, not recruiting --> Completed Trial primary completion date: Oct 2015 --> Jun 2014
- |||| Trial primary completion date: Study To Assess Pharmacokinetics, Safety & Efficacy of Anidulafungin When Treating Children With Invasive Candidiasis (clinicaltrials.gov) - Dec 12, 2015
P3, N=60, Recruiting, Sponsor: Pfizer
Trial primary completion date: Oct 2015 --> Jun 2014 Trial primary completion date: Jun 2016 --> May 2019
- Omegaven (omega-3 long-chain polyunsaturated fatty acids) / Fresenius Kabi
Trial primary completion date: FOILED: Fish OIL Optimal dosE Determination Study (clinicaltrials.gov) - Dec 10, 2015
P2, N=21, Recruiting, Sponsor: University Hospital Carl Gustav Carus
Trial primary completion date: Jun 2016 --> May 2019 Trial primary completion date: Dec 2015 --> Dec 2017
- ||| Trial completion, Enrollment change: VELPS: Validation of Early Warning Score & Lactate in Prehospital Screening (clinicaltrials.gov) - Dec 5, 2015
P=N/A, N=705, Completed, Sponsor: University of the West of Scotland
Trial primary completion date: Dec 2015 --> Dec 2017 Not yet recruiting --> Completed | N=1000 --> 705
- Trial completion, Trial primary completion date: Administration of Human Protein C Concentrates in Patients With Sepsis and Septic Shock. (clinicaltrials.gov) - Dec 5, 2015
P2, N=60, Completed, Sponsor: University of Roma La Sapienza
Not yet recruiting --> Completed | N=1000 --> 705 Recruiting --> Completed | Trial primary completion date: Sep 2014 --> Feb 2015
- Trial completion, Trial primary completion date: CLASSIC: Conservative vs. Liberal Approach to Fluid Therapy of Septic Shock in Intensive Care (clinicaltrials.gov) - Dec 4, 2015
P4, N=153, Completed, Sponsor: Anders Perner
Recruiting --> Completed | Trial primary completion date: Sep 2014 --> Feb 2015 Recruiting --> Completed | Trial primary completion date: Aug 2015 --> Nov 2015
- Trial primary completion date: PPV to Guide Fluid Management in the PICU (clinicaltrials.gov) - Dec 4, 2015
P=N/A, N=150, Enrolling by invitation, Sponsor: University of North Carolina, Chapel Hill
Recruiting --> Completed | Trial primary completion date: Aug 2015 --> Nov 2015 Trial primary completion date: Feb 2016 --> May 2016
- Enrollment closed: Immune Response of Patients With Chronic, Staphylococcus Aureus-infected Wounds (clinicaltrials.gov) - Nov 30, 2015
P=N/A, N=76, Active, not recruiting, Sponsor: Centre Hospitalier Universitaire de N?mes
Trial primary completion date: Feb 2016 --> May 2016 Recruiting --> Active, not recruiting
- Trial completion: Community-Onset Bacteremia Due to ESBL Producing E.Coli or K.Pneumoniae in China: Prevalence, Risk Factors and Prognosis (clinicaltrials.gov) - Nov 24, 2015
P=N/A, N=960, Completed, Sponsor: Jian-cang Zhou M.D.
Recruiting --> Active, not recruiting Enrolling by invitation --> Completed
- Trial primary completion date: Adsorbtion of Cytokines Early in Septic Shock: the ACESS Study (clinicaltrials.gov) - Nov 24, 2015
P=N/A, N=20, Recruiting, Sponsor: Domonkos Tr
Enrolling by invitation --> Completed Trial primary completion date: Oct 2015 --> Dec 2016
- ||| Gohibic (vilobelimab) / Staidson Biopharma, InflaRx
Enrollment closed, Trial primary completion date: SCIENS: Studying Complement Inhibition in Early, Newly Developing Septic Organ Dysfunction (clinicaltrials.gov) - Nov 21, 2015
P2, N=72, Active, not recruiting, Sponsor: InflaRx GmbH
Trial primary completion date: Oct 2015 --> Dec 2016 Recruiting --> Active, not recruiting | Trial primary completion date: Aug 2015 --> Dec 2015
- dexmedetomidine / Generic mfg.
Clinical: Dexmedetomidine on Microcirculation in Septic Shock (clinicaltrials.gov) - Nov 19, 2015
P4, N=30, Recruiting, Sponsor: Southeast University, China
Recruiting --> Active, not recruiting | Trial primary completion date: Aug 2015 --> Dec 2015 Completed --> Recruiting | Trial primary completion date: Apr 2015 --> Apr 2016
- tranexamic acid oral / Generic mfg.
Trial termination: Single Dose Enteral Tranexamic Acid in Critically Ill Patients (clinicaltrials.gov) - Nov 17, 2015
P2, N=4, Terminated, Sponsor: San Diego Veterans Healthcare System
Completed --> Recruiting | Trial primary completion date: Apr 2015 --> Apr 2016 Completed --> Terminated; Lower than anticipated enrollment
- ||||| Enrollment change: EUPHRATES: Safety and Efficacy of Polymyxin B Hemoperfusion (PMX) for Septic Shock (clinicaltrials.gov) - Nov 17, 2015
P3, N=478, Recruiting, Sponsor: Spectral Diagnostics (US) Inc.
Completed --> Terminated; Lower than anticipated enrollment N=650 --> 478
- || Trial primary completion date: Antibiotic Administration and Blood Culture Positivity in Severe Sepsis and Septic Shock (clinicaltrials.gov) - Nov 17, 2015
P=N/A, N=361, Recruiting, Sponsor: University of British Columbia
N=650 --> 478 Trial primary completion date: Dec 2015 --> Jun 2017
- Trial termination: EARTH-ICU: Early Physical Therapy in Patients With Sepsis (clinicaltrials.gov) - Nov 17, 2015
P=N/A, N=29, Terminated, Sponsor: Cliniques universitaires Saint-Luc- Universit
Trial primary completion date: Dec 2015 --> Jun 2017 Recruiting --> Terminated
- Trial primary completion date: Endothelium in Severe Sepsis (clinicaltrials.gov) - Nov 16, 2015
P=N/A, N=600, Recruiting, Sponsor: Beth Israel Deaconess Medical Center
Recruiting --> Terminated Trial primary completion date: Jan 2012 --> Jan 2017
- Trial primary completion date, Surgery: Does Serum Procalcitonin Levels Predict Sepsis in Patients Undergoing Cytoreductive Surgery (clinicaltrials.gov) - Nov 16, 2015
P1/2, N=20, Recruiting, Sponsor: Eastern Regional Medical Center
Trial primary completion date: Jan 2012 --> Jan 2017 Trial primary completion date: Jun 2015 --> Jun 2016
- | Trial completion, Trial primary completion date: ALBIOS: Volume Replacement With Albumin in Severe Sepsis (clinicaltrials.gov) - Nov 11, 2015
P3, N=1818, Completed, Sponsor: Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Trial primary completion date: Jun 2015 --> Jun 2016 Active, not recruiting --> Completed | Trial primary completion date: May 2012 --> Apr 2013
- ||| Biomarker, Enrollment open, Immune cell: Immune Failure in Critical Therapy (INFECT) Study (clinicaltrials.gov) - Nov 11, 2015
P=N/A, N=220, Recruiting, Sponsor: University of Edinburgh
Active, not recruiting --> Completed | Trial primary completion date: May 2012 --> Apr 2013 Not yet recruiting --> Recruiting