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55 Companies |
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51 Products |
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51 Products |
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62 Mechanisms of Action |
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0 Trials |
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1119 News |
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- Enrollment change, Trial withdrawal: Chlorhexidine Skin Application for Prevention of Infection in Infants Weighing <1500 g at Birth (clinicaltrials.gov) - Jul 19, 2016
P2/3, N=0, Withdrawn, Sponsor: All India Institute of Medical Sciences, New Delhi
N=1282 --> 0 | Not yet recruiting --> Withdrawn
- dabigatran etexilate / Generic mfg., argatroban / Generic mfg., enoxaparin sodium / Generic mfg.
Trial completion, Trial primary completion date: Direct Thrombin Inhibitors Versus LMWH in Staphylococcus Aureus Bacteraemia (clinicaltrials.gov) - Jul 14, 2016
P2, N=94, Completed, Sponsor: Universitaire Ziekenhuizen Leuven
N=1282 --> 0 | Not yet recruiting --> Withdrawn Recruiting --> Completed | Trial primary completion date: Jan 2016 --> Apr 2016
- ||| Trial completion, Enrollment change, Trial primary completion date: Post Marketing Surveillance Study To Observe Safety And Efficacy Of Eraxis® IV (clinicaltrials.gov) - Jun 30, 2016
P=N/A, N=244, Completed, Sponsor: Pfizer
Recruiting --> Completed | Trial primary completion date: Jan 2016 --> Apr 2016 Recruiting --> Completed | N=200 --> 244 | Trial primary completion date: Feb 2016 --> May 2016
- Trial completion: ARDS Prediction Score in Critically Ill Patients in China (clinicaltrials.gov) - Jun 28, 2016
P=N/A, N=698, Completed, Sponsor: Jianfeng Xie
Recruiting --> Completed | N=200 --> 244 | Trial primary completion date: Feb 2016 --> May 2016 Recruiting --> Completed
- ||||| Enrollment closed: EUPHRATES: Safety and Efficacy of Polymyxin B Hemoperfusion (PMX) for Septic Shock (clinicaltrials.gov) - Jun 23, 2016
P3, N=450, Active, not recruiting, Sponsor: Spectral Diagnostics (US) Inc.
Recruiting --> Completed Recruiting --> Active, not recruiting
- Trial completion, Enrollment change: PPV to Guide Fluid Management in the PICU (clinicaltrials.gov) - Jun 23, 2016
P=N/A, N=100, Completed, Sponsor: University of North Carolina, Chapel Hill
Recruiting --> Active, not recruiting Enrolling by invitation --> Completed | N=150 --> 100
- Trial completion, Trial primary completion date: TAMOF: Patient Plasma Response and Outcome in Septic Shock With Thrombocytopenia Associated Multiple Organ Failure in Children (clinicaltrials.gov) - Jun 16, 2016
P=N/A, N=86, Completed, Sponsor: Children's Healthcare of Atlanta
Enrolling by invitation --> Completed | N=150 --> 100 Recruiting --> Completed | Trial primary completion date: Dec 2012 --> Feb 2012
- Trial completion, Trial primary completion date: Evaluation in the Treatment of Nosocomial Sepsis Comparing Polymerase Chain Reaction With Conventional Blood Culture. (clinicaltrials.gov) - Jun 10, 2016
P4, N=200, Completed, Sponsor: Instituto do Coracao
Recruiting --> Completed | Trial primary completion date: Dec 2012 --> Feb 2012 Recruiting --> Completed | Trial primary completion date: Dec 2014 --> May 2016
- ||| Trial completion, Enrollment change, Trial primary completion date, Adverse events: Predicting Complications in Women With Toxaemia (clinicaltrials.gov) - Jun 2, 2016
P=N/A, N=650, Completed, Sponsor: University of British Columbia
Recruiting --> Completed | Trial primary completion date: Dec 2014 --> May 2016 Active, not recruiting --> Completed | N=2000 --> 650 | Trial primary completion date: Sep 2015 --> Dec 2010
- Trial completion, Enrollment change, Trial primary completion date: The Paediatric Refill Study (PRefill) (clinicaltrials.gov) - May 20, 2016
P=N/A, N=75, Completed, Sponsor: University of Nottingham
Active, not recruiting --> Completed | N=2000 --> 650 | Trial primary completion date: Sep 2015 --> Dec 2010 Recruiting --> Completed | N=135 --> 75 | Trial primary completion date: Dec 2015 --> Mar 2016
- Trial completion, Enrollment change, Trial primary completion date: Mean Systemic Filling Pressure and Heart Performance Predicting Fluid Responsiveness (clinicaltrials.gov) - May 20, 2016
P=N/A, N=40, Completed, Sponsor: Catharina Ziekenhuis Eindhoven
Recruiting --> Completed | N=135 --> 75 | Trial primary completion date: Dec 2015 --> Mar 2016 Recruiting --> Completed | N=60 --> 40 | Trial primary completion date: Aug 2014 --> Jan 2015
- Enrollment change, Trial termination, Trial primary completion date, Surgery: Impact of Early Goal-directed Fluid Therapy in Septic Patients Undergoing Emergency Surgery (clinicaltrials.gov) - May 14, 2016
P=N/A, N=20, Terminated, Sponsor: University Hospital, Geneva
Recruiting --> Completed | N=60 --> 40 | Trial primary completion date: Aug 2014 --> Jan 2015 N=250 --> 20 | Recruiting --> Terminated | Trial primary completion date: Dec 2013 --> Jun 2014; recrutment difficulties
- Enrollment closed, Surgery: Optimizing Prevention of Healthcare-Acquired Infections After Cardiac Surgery (HAI)_2 (clinicaltrials.gov) - May 14, 2016
P=N/A, N=330, Active, not recruiting, Sponsor: University of Michigan
N=250 --> 20 | Recruiting --> Terminated | Trial primary completion date: Dec 2013 --> Jun 2014; recrutment difficulties Recruiting --> Active, not recruiting
- Trial completion, Trial primary completion date, Surgery: Impact of Early Peri-operative Use of Polymyxin-B Hemoperfusion in Septic Patients Undergoing Emergent Abdominal Surgery (clinicaltrials.gov) - May 14, 2016
P=N/A, N=30, Completed, Sponsor: University Hospital, Geneva
Recruiting --> Active, not recruiting Recruiting --> Completed | Trial primary completion date: Dec 2013 --> Dec 2014
- Trial primary completion date: PreColos: Feeding Bovine Colostrum to Preterm Infants (clinicaltrials.gov) - May 13, 2016
P1/2, N=50, Recruiting, Sponsor: Per Torp Sangild
Recruiting --> Completed | Trial primary completion date: Dec 2013 --> Dec 2014 Trial primary completion date: Jun 2016 --> Oct 2016
- Enrollment change, Trial initiation date, Trial withdrawal: Bio-assay Development and Implementation for Fungal Infection Detection (clinicaltrials.gov) - May 13, 2016
P=N/A, N=0, Withdrawn, Sponsor: Universitaire Ziekenhuizen Leuven
Trial primary completion date: Jun 2016 --> Oct 2016 N=15 --> 0 | Initiation date: Feb 2015 --> Jun 2016 | Not yet recruiting --> Withdrawn
- Trial completion, Trial primary completion date: SEPP1B: Correlation Between PTP1B Expression and Organ Failure During Sepsis (clinicaltrials.gov) - May 13, 2016
P=N/A, N=54, Completed, Sponsor: University Hospital, Rouen
N=15 --> 0 | Initiation date: Feb 2015 --> Jun 2016 | Not yet recruiting --> Withdrawn Recruiting --> Completed | Trial primary completion date: Jan 2017 --> May 2016
- Enrollment closed, Enrollment change: Actigraphy to MEasuRe Intensive Care Unit Activity (clinicaltrials.gov) - May 12, 2016
P=N/A, N=25, Active, not recruiting, Sponsor: Vanderbilt University
Recruiting --> Completed | Trial primary completion date: Jan 2017 --> May 2016 Recruiting --> Active, not recruiting | N=75 --> 25
- Cubicin (daptomycin) / Merck (MSD)
Trial primary completion date, Monotherapy: Efficacy of Daptomycin Plus Fosfomycin Versus Daptomycin for Treatment of MRSA Bacteremia (clinicaltrials.gov) - May 10, 2016
P3, N=206, Recruiting, Sponsor: Miquel Pujol
Recruiting --> Active, not recruiting | N=75 --> 25 Trial primary completion date: Dec 2015 --> Dec 2016
- Solu-Cortef (hydrocortisone sodium succinate injection) / Pfizer
Trial completion, Enrollment change: StePS: Evaluation of Corticosteroid Therapy in Childhood Severe Sepsis - a Randomised Pilot Study (clinicaltrials.gov) - May 6, 2016
P2, N=21, Completed, Sponsor: University Hospital Southampton NHS Foundation Trust.
Trial primary completion date: Dec 2015 --> Dec 2016 Recruiting --> Completed | N=90 --> 21
- Trial primary completion date: Epidemiology, Acute Management, and Outcomes of Patients With Sepsis Presenting to a Referral Hospital in Western Kenya (clinicaltrials.gov) - May 6, 2016
P=N/A, N=440, Recruiting, Sponsor: Duke University
Recruiting --> Completed | N=90 --> 21 Trial primary completion date: Mar 2016 --> Aug 2016
- Trial termination, Trial primary completion date: Goal-directed Resuscitative Interventions During Pediatric Inter-facility Transport (The GRIPIT Trial) (clinicaltrials.gov) - May 6, 2016
P=N/A, N=230, Terminated, Sponsor: Arkansas Children's Hospital Research Institute
Trial primary completion date: Mar 2016 --> Aug 2016 Recruiting --> Terminated | Trial primary completion date: Sep 2012 --> Nov 2014
- Trial completion, Surgery: Does Serum Procalcitonin Levels Predict Sepsis in Patients Undergoing Cytoreductive Surgery (clinicaltrials.gov) - May 4, 2016
P1/2, N=20, Completed, Sponsor: Eastern Regional Medical Center
Recruiting --> Terminated | Trial primary completion date: Sep 2012 --> Nov 2014 Recruiting --> Completed
- Avastin (bevacizumab) / Roche
Enrollment change: Efficacy of Bevacizumab in Preventing Acute Respiratory Distress Syndrome (ARDS) (clinicaltrials.gov) - May 3, 2016
P2, N=0, Withdrawn, Sponsor: Weill Medical College of Cornell University
Recruiting --> Completed N=75 --> 0
- dexmedetomidine / Generic mfg.
Clinical: DESIRE: Dexmedetomidine for Sepsis in ICU Randomized Evaluation Trial (clinicaltrials.gov) - May 3, 2016
P4, N=203, Completed, Sponsor: Wakayama Medical University
N=75 --> 0 Recruiting --> Completed
- Trial primary completion date: Methionine Metabolism in Parenterally Fed Pediatric Sepsis (clinicaltrials.gov) - Apr 29, 2016
P=N/A, N=45, Recruiting, Sponsor: The Cleveland Clinic
Recruiting --> Completed Trial primary completion date: Oct 2014 --> Oct 2016
- Trial primary completion date: Methionine Metabolism in Enterally Fed Pediatric Sepsis (clinicaltrials.gov) - Apr 29, 2016
P=N/A, N=45, Recruiting, Sponsor: The Cleveland Clinic
Trial primary completion date: Oct 2014 --> Oct 2016 Trial primary completion date: Jul 2014 --> Oct 2016
- Trial completion, Enrollment change, Trial primary completion date: Gluconeogenesis Rates and Its Precursors in Pediatric Sepsis (clinicaltrials.gov) - Apr 29, 2016
P=N/A, N=19, Completed, Sponsor: The Cleveland Clinic
Trial primary completion date: Jul 2014 --> Oct 2016 Recruiting --> Completed | N=75 --> 19 | Trial primary completion date: May 2014 --> Oct 2013
- Turnobi (L-citrulline intravenous) / Asklepion Pharma
Trial completion, Trial primary completion date: Citrulline in Severe Sepsis (clinicaltrials.gov) - Apr 29, 2016
P2, N=72, Completed, Sponsor: Vanderbilt University
Recruiting --> Completed | N=75 --> 19 | Trial primary completion date: May 2014 --> Oct 2013 Recruiting --> Completed | Trial primary completion date: Dec 2015 --> Mar 2016
- Trial completion, Enrollment change, Trial primary completion date: Virulence Determinants in S Aureus Bacteremia (clinicaltrials.gov) - Apr 29, 2016
P=N/A, N=1354, Completed, Sponsor: Duke University
Recruiting --> Completed | Trial primary completion date: Dec 2015 --> Mar 2016 Recruiting --> Completed | N=10000 --> 1354 | Trial primary completion date: Dec 2020 --> Aug 2013
- |||| Gohibic (vilobelimab) / Staidson Biopharma, InflaRx
Trial completion: SCIENS: Studying Complement Inhibition in Early, Newly Developing Septic Organ Dysfunction (clinicaltrials.gov) - Apr 26, 2016
P2, N=72, Completed, Sponsor: InflaRx GmbH
Recruiting --> Completed | N=10000 --> 1354 | Trial primary completion date: Dec 2020 --> Aug 2013 Active, not recruiting --> Completed
- Ventavis (iloprost) / Bayer, J&J, University of Copenhagen, Integrilin (eptifibatide) / Takeda
Enrollment change, Trial termination, Trial primary completion date: Integrilin and Ilomedin in Combination in Comparison to Standard Treatment in Severe Pneumonia Patients With Severe Sepsis (clinicaltrials.gov) - Apr 23, 2016
P2, N=5, Terminated, Sponsor: Thrombologic ApS
Active, not recruiting --> Completed N=36 --> 5 | Suspended --> Terminated | Trial primary completion date: Dec 2013 --> Mar 2014; Difficulty recruiting patients, company closed down
- Gemiglo (gemigliptin) / Sanofi, LG Chem
Trial completion: Effect of Gemigliptin on Metabolic Endotoxemia and Lipemia (clinicaltrials.gov) - Apr 21, 2016
P=N/A, N=10, Completed, Sponsor: Seoul National University Hospital
N=36 --> 5 | Suspended --> Terminated | Trial primary completion date: Dec 2013 --> Mar 2014; Difficulty recruiting patients, company closed down Not yet recruiting --> Completed
- Enrollment change, Trial primary completion date: Neutropenic Fever, Inflammatory Markers and Sepsis in Haematological Patients (clinicaltrials.gov) - Apr 20, 2016
P=N/A, N=270, Recruiting, Sponsor: Kuopio University Hospital
Not yet recruiting --> Completed N=137 --> 270 | Trial primary completion date: Dec 2015 --> Dec 2016
- Clinical: Bacteremia Antibiotic Length Actually Needed for Clinical Effectiveness: A Pilot RCT (clinicaltrials.gov) - Apr 19, 2016
P=N/A, N=115, Recruiting, Sponsor: Sunnybrook Health Sciences Centre
N=137 --> 270 | Trial primary completion date: Dec 2015 --> Dec 2016 Trial primary completion date: Oct 2015 --> Oct 2016
- Trial primary completion date: Cerebral Oxygenation in Septic Patients Using Vasopressors - the Conscious Study (clinicaltrials.gov) - Apr 15, 2016
P=N/A, N=40, Recruiting, Sponsor: Karl-Andre Wian
Trial primary completion date: Oct 2015 --> Oct 2016 Trial primary completion date: Mar 2016 --> Jan 2017
- Cubicin (daptomycin) / Merck (MSD)
Enrollment change, Trial termination: Vancomycin Versus Daptomycin for the Treatment of Methicillin Resistant Staphylococcus Aureus (MRSA) Bacteremia (clinicaltrials.gov) - Apr 15, 2016
P2b, N=14, Terminated, Sponsor: Singapore General Hospital
Trial primary completion date: Mar 2016 --> Jan 2017 N=50 --> 14 | Recruiting --> Terminated; slow accrual of participants
- Trial completion, Enrollment change: Effects of Early Exercise Rehabilitation on Long-term Functional Recovery in Patients With Severe Sepsis (clinicaltrials.gov) - Apr 14, 2016
P=N/A, N=40, Completed, Sponsor: Yonsei University
N=50 --> 14 | Recruiting --> Terminated; slow accrual of participants Recruiting --> Completed | N=220 --> 40
- Trial completion, Trial primary completion date: iVAP: Immune Suppression and Ventilator Associated Pneumonias (clinicaltrials.gov) - Apr 12, 2016
P=N/A, N=50, Completed, Sponsor: Matthew Exline
Recruiting --> Completed | N=220 --> 40 Enrolling by invitation --> Completed | Trial primary completion date: Jun 2014 --> Nov 2012
- Trial completion: Immune Response of Patients With Chronic, Staphylococcus Aureus-infected Wounds (clinicaltrials.gov) - Apr 7, 2016
P=N/A, N=69, Completed, Sponsor: Centre Hospitalier Universitaire de Nīmes
Enrolling by invitation --> Completed | Trial primary completion date: Jun 2014 --> Nov 2012 Active, not recruiting --> Completed
- Vabomere (meropenem/vaborbactam) / Melinta Therap
Trial primary completion date: Efficacy, Safety, Tolerability of Vabomere Compared to Best Available Therapy in Treating Serious Infections in Adults (clinicaltrials.gov) - Apr 7, 2016
P3, N=150, Recruiting, Sponsor: Rempex Pharmaceuticals (a wholly owned subsidiary of The Medicines Company)
Active, not recruiting --> Completed Trial primary completion date: Jan 2016 --> Dec 2016
- Trial primary completion date: ASSET - a Double-Blind, Randomized Placebo-Controlled Clinical Investigation With Alteco (clinicaltrials.gov) - Apr 6, 2016
P=N/A, N=32, Recruiting, Sponsor: Alteco Medical AB
Trial primary completion date: Jan 2016 --> Dec 2016 Trial primary completion date: Sep 2016 --> Apr 2017
- Trial primary completion date: CONFOCAL: Cerebral Oxygenation and Neurological Outcomes FOllowing CriticAL Illness (clinicaltrials.gov) - Mar 31, 2016
P=N/A, N=150, Recruiting, Sponsor: Queen's University
Trial primary completion date: Sep 2016 --> Apr 2017 Trial primary completion date: Dec 2018 --> Nov 2017
- Trial primary completion date: Early Goal Directed Therapy in Sepsis by Emergency Medical Services (clinicaltrials.gov) - Mar 28, 2016
P=N/A, N=200, Recruiting, Sponsor: Massachusetts General Hospital
Trial primary completion date: Dec 2018 --> Nov 2017 Trial primary completion date: May 2016 --> May 2017
- Solu-Cortef (hydrocortisone sodium succinate injection) / Pfizer
Trial primary completion date: ADRENAL: ADjunctive coRticosteroid trEatment iN criticAlly ilL Patients With Septic Shock (clinicaltrials.gov) - Mar 25, 2016
P4, N=3800, Recruiting, Sponsor: The George Institute
Trial primary completion date: May 2016 --> May 2017 Trial primary completion date: Jun 2016 --> Dec 2016
- Trial completion, Enrollment change: Hepcidin Levels in Preterm Infants (clinicaltrials.gov) - Mar 17, 2016
P=N/A, N=62, Completed, Sponsor: Meir Medical Center
Trial primary completion date: Jun 2016 --> Dec 2016 Recruiting --> Completed | N=50 --> 62
- Cubicin (daptomycin) / Merck (MSD)
Trial initiation date: Daptomycin in the Treatment of Subjects With Infective Endocarditis or Bacteremia Due to S. Aureus (clinicaltrials.gov) - Mar 15, 2016
P3, N=0, Completed, Sponsor: Cubist Pharmaceuticals LLC
Recruiting --> Completed | N=50 --> 62 Initiation date: Aug 2002 --> Mar 2002
- Enrollment change: Rapid Identification and Susceptibility Testing of Pathogens From Blood Cultures (clinicaltrials.gov) - Mar 15, 2016
P=N/A, N=743, Completed, Sponsor: Mayo Clinic
Initiation date: Aug 2002 --> Mar 2002 N=617 --> 743
- Trial primary completion date: Causes and Factors Associated With Outcomes in Community-acquired Sepsis and Severe Sepsis in Northeast Thailand (clinicaltrials.gov) - Mar 11, 2016
P=N/A, N=5020, Recruiting, Sponsor: University of Oxford
N=617 --> 743 Trial primary completion date: Feb 2016 --> Feb 2017
- Trial primary completion date: The Cooling And Surviving Septic Shock Study (CASS) (clinicaltrials.gov) - Mar 9, 2016
P2/3, N=560, Recruiting, Sponsor: Danish Procalcitonin Study Group
Trial primary completion date: Feb 2016 --> Feb 2017 Trial primary completion date: Dec 2016 --> Oct 2017