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53 Companies |
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51 Products |
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51 Products |
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62 Mechanisms of Action |
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0 Trials |
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1105 News |
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- | Clinical: Bacteremia Antibiotic Length Actually Needed for Clinical Effectiveness: A Pilot RCT (clinicaltrials.gov) - Apr 5, 2017
P=N/A, N=115, Recruiting, Sponsor: Sunnybrook Health Sciences Centre
Trial primary completion date: Mar 2017 --> Sep 2017
- | Trial primary completion date: The Checklist for Early Recognition and Treatment of Acute Illness (CERTAIN) (clinicaltrials.gov) - Mar 22, 2017
P=N/A, N=15000, Recruiting, Sponsor: Mayo Clinic
Trial primary completion date: Mar 2017 --> Sep 2017 Trial primary completion date: Dec 2016 --> Dec 2017
- | Trial completion: Methionine Metabolism in Parenterally Fed Pediatric Sepsis (clinicaltrials.gov) - Mar 22, 2017
P=N/A, N=45, Completed, Sponsor: The Cleveland Clinic
Trial primary completion date: Dec 2016 --> Dec 2017 Recruiting --> Completed
- | Trial completion: Methionine Metabolism in Enterally Fed Pediatric Sepsis (clinicaltrials.gov) - Mar 22, 2017
P=N/A, N=45, Completed, Sponsor: The Cleveland Clinic
Recruiting --> Completed Recruiting --> Completed
- Mycamine (micafungin) / Astellas
Enrollment change: Fluconazole Versus Micafungin for Candida Bloodstream Infection in Non-Neutropenic Patients (clinicaltrials.gov) - Mar 15, 2017
P4, N=0, Withdrawn, Sponsor: Kyoto University
Recruiting --> Completed N=190 --> 0
- | Trial primary completion date: Adsorbtion of Cytokines Early in Septic Shock: the ACESS Study (clinicaltrials.gov) - Mar 9, 2017
P=N/A, N=20, Recruiting, Sponsor: Domonkos Tr
N=190 --> 0 Trial primary completion date: Dec 2016 --> Dec 2017
- || Trial primary completion date: Changes in Exhaled 13CO2/12CO2 Breath Delta Value as an Early Indicator of Infection in ICU Patients (clinicaltrials.gov) - Mar 7, 2017
P2, N=110, Recruiting, Sponsor: Isomark, LLC
Trial primary completion date: Dec 2016 --> Dec 2017 Trial primary completion date: Dec 2016 --> Dec 2017
- | Trial completion, Phase classification: ACT-ICU Study: Activity and Cognitive Therapy in the Intensive Care Unit (clinicaltrials.gov) - Mar 3, 2017
P=N/A, N=87, Completed, Sponsor: Vanderbilt University
Trial primary completion date: Dec 2016 --> Dec 2017 Active, not recruiting --> Completed | Phase classification: P1 --> PN/A
- || Trial primary completion date: VENUS: Septic Gene Expression Using SeptiCyte (clinicaltrials.gov) - Mar 3, 2017
P=N/A, N=370, Active, not recruiting, Sponsor: Immunexpress
Active, not recruiting --> Completed | Phase classification: P1 --> PN/A Trial primary completion date: Dec 2016 --> Apr 2017
- | Enrollment change, Trial withdrawal: Muscle Atrophy in Sepsis (clinicaltrials.gov) - Feb 28, 2017
P=N/A, N=0, Withdrawn, Sponsor: Gregory A. Schmidt
Trial primary completion date: Dec 2016 --> Apr 2017 N=25 --> 0 | Recruiting --> Withdrawn
- | Enrollment closed: NOMS: Impact of Sunflower Seed Oil Massage on Neonatal Mortality and Morbidity in Nepal (clinicaltrials.gov) - Feb 23, 2017
P3, N=29260, Active, not recruiting, Sponsor: Johns Hopkins Bloomberg School of Public Health
N=25 --> 0 | Recruiting --> Withdrawn Recruiting --> Active, not recruiting
- Phase classification, Enrollment change, Trial termination: SAFEbt: S.A.F.E.BT System Extracorporeal Treatment With DIAPACT CRRT (clinicaltrials.gov) - Feb 6, 2017
P=N/A, N=16, Terminated, Sponsor: B. Braun Medical Inc.
Phase classification: P2 --> P=N/A | N=120 --> 16 | Suspended --> Terminated; Study stopped for operational futility. Due to very small numbers of subjects, insufficient data was available for results to provide meaningful conclusions.
- Enrollment change, Trial termination: IDEAL-ICU: I.D.E.A.L.-I.C.U. (Initiation of Dialysis EArly Versus deLayed in Intensive Care Unit) (clinicaltrials.gov) - Feb 2, 2017
P3, N=500, Terminated, Sponsor: Centre Hospitalier Universitaire Dijon
Due to very small numbers of subjects, insufficient data was available for results to provide meaningful conclusions. N=864 --> 500 | Recruiting --> Terminated
- Enrollment change, Trial termination, Trial primary completion date: The Ohio State University Sepsis Registry (clinicaltrials.gov) - Feb 1, 2017
P=N/A, N=230, Terminated, Sponsor: Ohio State University
N=864 --> 500 | Recruiting --> Terminated N=1500 --> 230 | Suspended --> Terminated | Trial primary completion date: Feb 2012 --> Nov 2011; Lack of resources has prevented the study from continuation.
- Trial completion: The Effect of Three Different Fluids(Albumin 5%, Normal Saline, Hydroxyethyl Starch 130 kD) on Microcirculation in Severe Sepsis/Septic Shock Patients (clinicaltrials.gov) - Jan 26, 2017
P=N/A, N=45, Completed, Sponsor: Mercy Research
N=1500 --> 230 | Suspended --> Terminated | Trial primary completion date: Feb 2012 --> Nov 2011; Lack of resources has prevented the study from continuation. Not yet recruiting --> Completed
- Enrollment change, Trial withdrawal: Presep and Vascath Interaction Study (clinicaltrials.gov) - Jan 24, 2017
P=N/A, N=0, Withdrawn, Sponsor: Wake Forest University Health Sciences
Not yet recruiting --> Completed N=100 --> 0 | Terminated --> Withdrawn
- Cubicin (daptomycin) / Merck (MSD)
Trial primary completion date, Monotherapy: Efficacy of Daptomycin Plus Fosfomycin Versus Daptomycin for Treatment of MRSA Bacteremia (clinicaltrials.gov) - Jan 19, 2017
P3, N=206, Recruiting, Sponsor: Miquel Pujol
N=100 --> 0 | Terminated --> Withdrawn Trial primary completion date: Dec 2016 --> Dec 2017
- ||| Trial completion: TailoredT: Prospective Study to Characterize Host-pathogen Related Factors in Hospitalized and ED Patients With LRTI and/or Sepsis (clinicaltrials.gov) - Jan 13, 2017
P=N/A, N=1200, Completed, Sponsor: MeMed Diagnostics Ltd.
Trial primary completion date: Dec 2016 --> Dec 2017 Active, not recruiting --> Completed
- Trial completion: Actigraphy to MEasuRe Intensive Care Unit Activity (clinicaltrials.gov) - Jan 6, 2017
P=N/A, N=25, Completed, Sponsor: Vanderbilt University
Active, not recruiting --> Completed Active, not recruiting --> Completed
- Enrollment closed: PreColos: Feeding Bovine Colostrum to Preterm Infants (clinicaltrials.gov) - Jan 4, 2017
P1/2, N=52, Active, not recruiting, Sponsor: Per Torp Sangild
Active, not recruiting --> Completed Recruiting --> Active, not recruiting
- Clinical: Bacteremia Antibiotic Length Actually Needed for Clinical Effectiveness: A Pilot RCT (clinicaltrials.gov) - Dec 22, 2016
P=N/A, N=115, Recruiting, Sponsor: Sunnybrook Health Sciences Centre
Recruiting --> Active, not recruiting Trial primary completion date: Oct 2016 --> Mar 2017
- midazolam hydrochloride / Generic mfg., dexmedetomidine / Generic mfg.
Clinical: The Effect of Dexmedetomidine on Microcirculation in Severe Sepsis (clinicaltrials.gov) - Dec 21, 2016
P4, N=60, Recruiting, Sponsor: National Taiwan University Hospital
Trial primary completion date: Oct 2016 --> Mar 2017 Trial primary completion date: Jun 2017 --> Jun 2018
- Enrollment change, Trial termination: Cerebral Oxygenation in Septic Patients Using Vasopressors - the Conscious Study (clinicaltrials.gov) - Dec 14, 2016
P=N/A, N=15, Terminated, Sponsor: Karl-Andre Wian
Trial primary completion date: Jun 2017 --> Jun 2018 N=40 --> 15 | Recruiting --> Terminated; Too slow recruitment.
- Trial completion, Enrollment change, Trial primary completion date: Genetic Polymorphisms & The Risk for Sepsis After Trauma (clinicaltrials.gov) - Dec 7, 2016
P=N/A, N=357, Completed, Sponsor: University of Washington
N=40 --> 15 | Recruiting --> Terminated; Too slow recruitment. Recruiting --> Completed | N=3000 --> 357 | Trial primary completion date: Dec 2016 --> Dec 2014
- vancomycin / Generic mfg.
Trial primary completion date: RCT of Continuous Versus Intermittent Infusion of Vancomycin in Neonates (clinicaltrials.gov) - Dec 6, 2016
P=N/A, N=200, Recruiting, Sponsor: Murdoch Childrens Research Institute
Recruiting --> Completed | N=3000 --> 357 | Trial primary completion date: Dec 2016 --> Dec 2014 Trial primary completion date: Sep 2017 --> Dec 2017
- Enrollment closed, Enrollment change: Epidemiology, Acute Management, and Outcomes of Patients With Sepsis Presenting to a Referral Hospital in Western Kenya (clinicaltrials.gov) - Dec 2, 2016
P=N/A, N=198, Active, not recruiting, Sponsor: Duke University
Trial primary completion date: Sep 2017 --> Dec 2017 Recruiting --> Active, not recruiting | N=440 --> 198
- Trial completion, Enrollment change, Trial primary completion date: CONFOCAL: Cerebral Oxygenation and Neurological Outcomes FOllowing CriticAL Illness (clinicaltrials.gov) - Nov 27, 2016
P=N/A, N=116, Completed, Sponsor: Queen's University
Recruiting --> Active, not recruiting | N=440 --> 198 Recruiting --> Completed | N=150 --> 116 | Trial primary completion date: Nov 2017 --> Sep 2016
- Enrollment change, Trial termination, Trial primary completion date: The Cooling And Surviving Septic Shock Study (CASS) (clinicaltrials.gov) - Nov 23, 2016
P2/3, N=433, Terminated, Sponsor: Danish Procalcitonin Study Group
Recruiting --> Completed | N=150 --> 116 | Trial primary completion date: Nov 2017 --> Sep 2016 N=560 --> 433 | Recruiting --> Terminated | Trial primary completion date: Oct 2017 --> Nov 2016; Futility
- Enrollment change, Trial initiation date, Trial termination, Trial primary completion date: Prevalence of CVC-associated Sepsis and Use of Blood Cultures in Berlin - Brandenburg (clinicaltrials.gov) - Nov 23, 2016
P=N/A, N=13, Terminated, Sponsor: Charite University, Berlin, Germany
N=560 --> 433 | Recruiting --> Terminated | Trial primary completion date: Oct 2017 --> Nov 2016; Futility N=80 --> 13 | Initiation date: Jul 2011 --> Aug 2009 | Recruiting --> Terminated | Trial primary completion date: Jul 2015 --> Dec 2010
- Trial completion, Enrollment change, Trial primary completion date: Human Suis and Pig Diseases in Northern Vietnam (clinicaltrials.gov) - Nov 15, 2016
P=N/A, N=273, Completed, Sponsor: Oxford University Clinical Research Unit, Vietnam
N=80 --> 13 | Initiation date: Jul 2011 --> Aug 2009 | Recruiting --> Terminated | Trial primary completion date: Jul 2015 --> Dec 2010 Recruiting --> Completed | N=350 --> 273 | Trial primary completion date: Nov 2014 --> Dec 2011
- || Trial primary completion date: Antibiotic Administration and Blood Culture Positivity in Severe Sepsis and Septic Shock (clinicaltrials.gov) - Nov 3, 2016
P=N/A, N=361, Recruiting, Sponsor: University of British Columbia
Recruiting --> Completed | N=350 --> 273 | Trial primary completion date: Nov 2014 --> Dec 2011 Trial primary completion date: Jun 2017 --> Jun 2018
- Enrollment closed, Trial primary completion date: Patient Centered Cloud-based Electronic System: Ambient Warning and Response Evaluation (ProCCESs AWARE) (clinicaltrials.gov) - Nov 2, 2016
P=N/A, N=12000, Active, not recruiting, Sponsor: Mayo Clinic
Trial primary completion date: Jun 2017 --> Jun 2018 Recruiting --> Active, not recruiting | Trial primary completion date: Jun 2016 --> Dec 2016
- Enrollment change, Trial termination, Trial primary completion date: Changes in 13CO2/12CO2 Delta Value in Exhaled Breath as an Early Indicator of Infection in Adult Trauma Subjects (clinicaltrials.gov) - Oct 28, 2016
P=N/A, N=11, Terminated, Sponsor: University of Wisconsin, Madison
Recruiting --> Active, not recruiting | Trial primary completion date: Jun 2016 --> Dec 2016 N=110 --> 11 | Recruiting --> Terminated | Trial primary completion date: Oct 2016 --> Mar 2016; Low enrollment
- || Enrollment closed, Enrollment change, Trial primary completion date: VENUS: Septic Gene Expression Using SeptiCyte (clinicaltrials.gov) - Oct 26, 2016
P=N/A, N=360, Active, not recruiting, Sponsor: Immunexpress
N=110 --> 11 | Recruiting --> Terminated | Trial primary completion date: Oct 2016 --> Mar 2016; Low enrollment Recruiting --> Active, not recruiting | N=180 --> 360 | Trial primary completion date: Apr 2015 --> Dec 2016
- ||| Trial completion: Early PREdiction of Severe Sepsis I (ExPRES-Sepsis I) Study (clinicaltrials.gov) - Oct 26, 2016
P=N/A, N=401, Completed, Sponsor: University of Edinburgh
Recruiting --> Active, not recruiting | N=180 --> 360 | Trial primary completion date: Apr 2015 --> Dec 2016 Recruiting --> Completed
- ||| Biomarker, Trial completion, Enrollment change, Immune cell: Immune Failure in Critical Therapy (INFECT) Study (clinicaltrials.gov) - Oct 26, 2016
P=N/A, N=168, Completed, Sponsor: University of Edinburgh
Recruiting --> Completed Recruiting --> Completed | N=220 --> 168
- Trial primary completion date, Surgery: Optimizing Prevention of Healthcare-Acquired Infections After Cardiac Surgery (HAI)_2 (clinicaltrials.gov) - Oct 26, 2016
P=N/A, N=330, Active, not recruiting, Sponsor: University of Michigan
Recruiting --> Completed | N=220 --> 168 Trial primary completion date: Sep 2016 --> Oct 2017
- ceftriaxone / Generic mfg., gentamicin sulfate / Generic mfg.
Trial completion, Enrollment change: Infaseme: Infant Severe Sepsis and Bacterial Meningitis in Malawi (clinicaltrials.gov) - Oct 26, 2016
P4, N=351, Completed, Sponsor: University of Malawi College of Medicine
Trial primary completion date: Sep 2016 --> Oct 2017 Active, not recruiting --> Completed | N=238 --> 351
- cefazolin / Generic mfg.
Trial primary completion date: An Open Label Study to Describe the Pharmacokinetics of Cefazolin in Preterm Neonates (clinicaltrials.gov) - Oct 20, 2016
P1, N=9, Active, not recruiting, Sponsor: Phillip Brian Smith
Active, not recruiting --> Completed | N=238 --> 351 Trial primary completion date: Jul 2016 --> Jul 2017
- Solu-Cortef (hydrocortisone sodium succinate injection) / Pfizer
Trial primary completion date: Hyperglycemia and Effects of Daily 100 mg Versus 200 mg of Hydrocortisone Therapy in Patients With Septic Shock (clinicaltrials.gov) - Sep 15, 2016
P4, N=80, Recruiting, Sponsor: Srinakharinwirot University
Trial primary completion date: Jul 2016 --> Jul 2017 Trial primary completion date: Jun 2016 --> Dec 2016
- Enrollment change, Trial withdrawal, Trial primary completion date: Maternal and Neonatal Outcomes of the Use of Vasopressors to Treat Hypotension During Spinal Anesthesia for Cesarean (clinicaltrials.gov) - Sep 7, 2016
P3, N=0, Withdrawn, Sponsor: Instituto Materno Infantil Prof. Fernando Figueira
Trial primary completion date: Jun 2016 --> Dec 2016 N=55 --> 0 | Recruiting --> Withdrawn | Trial primary completion date: Jun 2012 --> Jun 2014
- || Trial primary completion date: Changes in Exhaled 13CO2/12CO2 Breath Delta Value as an Early Indicator of Infection in ICU Patients (clinicaltrials.gov) - Sep 7, 2016
P2, N=110, Recruiting, Sponsor: Isomark, LLC
N=55 --> 0 | Recruiting --> Withdrawn | Trial primary completion date: Jun 2012 --> Jun 2014 Trial primary completion date: Jun 2016 --> Dec 2016
- midodrine hydrochloride / Generic mfg.
Trial completion, Trial primary completion date: MACHT: Effect of Midodrine and Albumine in the Prevention of Complications in Cirrhotic Patients Awaiting Liver Transplantation (clinicaltrials.gov) - Aug 19, 2016
P4, N=199, Completed, Sponsor: Hospital Clinic of Barcelona
Trial primary completion date: Jun 2016 --> Dec 2016 Recruiting --> Completed | Trial primary completion date: Apr 2015 --> Feb 2016
- | Trial completion, Trial primary completion date: Pilot Study for the SQUEEZE Trial (clinicaltrials.gov) - Aug 19, 2016
P3, N=53, Completed, Sponsor: McMaster Children's Hospital
Recruiting --> Completed | Trial primary completion date: Apr 2015 --> Feb 2016 Recruiting --> Completed | Trial primary completion date: Jul 2015 --> Jun 2016
- Trial completion: Assessment of Coagulation Profile and Haematopoietic Responses in Patients With Acute-on-chronic Liver Failure During Systemic Inflammatory Response (SIRS) and Sepsis (clinicaltrials.gov) - Aug 19, 2016
P=N/A, N=114, Completed, Sponsor: Institute of Liver and Biliary Sciences, India
Recruiting --> Completed | Trial primary completion date: Jul 2015 --> Jun 2016 Recruiting --> Completed
- Enrollment change, Trial primary completion date, Gram negative: Duration of Antibiotics for the Treatment of Gram-negative Bacilli Bacteremia (clinicaltrials.gov) - Aug 10, 2016
P=N/A, N=600, Recruiting, Sponsor: Rabin Medical Center
Recruiting --> Completed N=400 --> 600 | Trial primary completion date: Jan 2017 --> Jan 2019
- Trial completion, Trial primary completion date: Impact of Dopamine Infusion on Insulin Secretion in Healthy Subjects (clinicaltrials.gov) - Aug 9, 2016
P1, N=15, Completed, Sponsor: Albert Einstein College of Medicine of Yeshiva University
N=400 --> 600 | Trial primary completion date: Jan 2017 --> Jan 2019 Recruiting --> Completed | Trial primary completion date: Jul 2016 --> Jan 2016
- Trial primary completion date: Lactated Ringer Versus Albumin in Early Sepsis Therapy (clinicaltrials.gov) - Aug 8, 2016
P3, N=360, Recruiting, Sponsor: University of Sao Paulo
Recruiting --> Completed | Trial primary completion date: Jul 2016 --> Jan 2016 Trial primary completion date: Apr 2014 --> Oct 2016
- || leflunomide / Generic mfg.
Trial primary completion date: An Open-Label, Study to Treat Patients With Renal Allograft and Polyoma BK Viruria (clinicaltrials.gov) - Jul 26, 2016
P2, N=60, Recruiting, Sponsor: Changzheng-Cinkate
Trial primary completion date: Apr 2014 --> Oct 2016 Trial primary completion date: Dec 2015 --> Dec 2017
- vancomycin / Generic mfg.
Trial primary completion date: Bacteremia: Treatment Algorithm to Reduce the Use of Vancomycin in Adults With Blood Stream Infection (clinicaltrials.gov) - Jul 19, 2016
P2, N=500, Recruiting, Sponsor: Duke University
Trial primary completion date: Dec 2015 --> Dec 2017 Trial primary completion date: Jun 2016 --> Apr 2017