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55 Companies |
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51 Products |
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51 Products |
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62 Mechanisms of Action |
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0 Trials |
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1119 News |
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- | Trial completion: TRISS: Transfusion-requirements in Septic Shock Trial (clinicaltrials.gov) - Oct 4, 2014
P3, N=1005, Completed, Sponsor: Scandinavian Critical Care Trials Group
Active, not recruiting --> Completed
- ||||| Gohibic (vilobelimab) / Staidson Biopharma, InflaRx
New P2 trial: SCIENS: Studying Complement Inhibition in Early, Newly Developing Septic Organ Dysfunction (clinicaltrials.gov) - Sep 28, 2014
P2, N=72, Recruiting, Sponsor: InflaRx GmbH
- vancomycin / Generic mfg.
Enrollment open: RCT of Continuous Versus Intermittent Infusion of Vancomycin in Neonates (clinicaltrials.gov) - Sep 28, 2014
P=N/A, N=200, Recruiting, Sponsor: Murdoch Childrens Research Institute
Active, not recruiting --> Completed Not yet recruiting --> Recruiting
- Ventavis (iloprost) / Bayer, J&J, University of Copenhagen, Integrilin (eptifibatide) / Takeda
Enrollment open: CO-ILEPSS: Co-administration of Iloprost and Eptifibatide in Septic Shock Patients (clinicaltrials.gov) - Sep 28, 2014
P2, N=18, Recruiting, Sponsor: Sisse R. Ostrowski, MD PhD DMSc
Not yet recruiting --> Recruiting Not yet recruiting --> Recruiting
- || Enrollment closed, Enrollment change, Trial primary completion date: EMOS: Procurement of Human Specimens for the Evaluation of Early Markers of Sepsis (clinicaltrials.gov) - Sep 28, 2014
P=N/A, N=950, Active, not recruiting, Sponsor: Abbott Diagnostics Division
Not yet recruiting --> Recruiting Recruiting --> Active, not recruiting | N=1200 --> 950 | Trial primary completion date: Jul 2014 --> Dec 2014
- Trial completion, Enrollment change: Emergency Department Management of Sepsis Patients: A Goal-Oriented Non-Invasive Sepsis Trial (clinicaltrials.gov) - Sep 28, 2014
P=N/A, N=122, Completed, Sponsor: National University Hospital, Singapore
Recruiting --> Active, not recruiting | N=1200 --> 950 | Trial primary completion date: Jul 2014 --> Dec 2014 Recruiting --> Completed | N=160 --> 122
- |||||||||| Prezista (darunavir) / J&J, Isentress (raltegravir) / Merck (MSD)
New P3 trial: Management of Participants With Low-level Persistent Viremia (ANRS 161 L-VIR) (clinicaltrials.gov) - Sep 28, 2014
P3, N=120, Not yet recruiting, Sponsor: French National Institute for Health and Medical Research-French National Agency for Research on AIDS and Viral Hepatitis (Inserm-ANRS)
- ||||||| Mycamine (micafungin) / Astellas
Trial completion: Micafungin Versus AmBisome in Invasive Candidiasis and Candidemia (clinicaltrials.gov) - Sep 17, 2014
P3, N=637, Completed, Sponsor: Astellas Pharma Inc
Recruiting --> Completed | N=160 --> 122 No longer recruiting --> Completed
- ||||||| Mycamine (micafungin) / Astellas
Trial completion: Study of Micafungin in Patients With Invasive Candidiasis or Candidemia (clinicaltrials.gov) - Sep 17, 2014
P3, N=611, Completed, Sponsor: Astellas Pharma Inc
No longer recruiting --> Completed No longer recruiting --> Completed
- gentamicin sulfate / Generic mfg., amoxicillin / Generic mfg.
Trial completion: Simplified Antibiotic Regimens for Outpatient Treatment of Suspected Sepsis in Neonates and Young Infants in Bangladesh (clinicaltrials.gov) - Sep 16, 2014
P=N/A, N=2490, Completed, Sponsor: Johns Hopkins Bloomberg School of Public Health
No longer recruiting --> Completed Enrolling by invitation --> Completed
- Trial completion, Enrollment change, Trial primary completion date: Indicators of Inflammation and Coagulation in Sepsis (clinicaltrials.gov) - Sep 12, 2014
P=N/A, N=500, Completed, Sponsor: University of Oklahoma
Enrolling by invitation --> Completed Recruiting --> Completed | N=200 --> 500 | Trial primary completion date: Dec 2015 --> May 2014
- Clinical: Cerebral Oxygenation in Septic Patients Using Vasopressors - the Conscious Study (clinicaltrials.gov) - Sep 11, 2014
P=N/A, N=40, Not yet recruiting, Sponsor: Karl-Andre Wian
- Trial primary completion date: Impact of Dopamine Infusion on Insulin Secretion in Healthy Subjects (clinicaltrials.gov) - Sep 11, 2014
P1, N=15, Recruiting, Sponsor: Albert Einstein College of Medicine of Yeshiva University
Recruiting --> Completed | N=200 --> 500 | Trial primary completion date: Dec 2015 --> May 2014 Trial primary completion date: Aug 2014 --> Feb 2015
- Enrollment open, Trial initiation date, Trial primary completion date: CLASSIC: Conservative vs. Liberal Approach to Fluid Therapy of Septic Shock in Intensive Care (clinicaltrials.gov) - Sep 8, 2014
P4, N=150, Recruiting, Sponsor: Anders Perner
Trial primary completion date: Aug 2014 --> Feb 2015 Not yet recruiting --> Recruiting | Initiation date: May 2014 --> Sep 2014 | Trial primary completion date: Mar 2015 --> Aug 2015
- vancomycin / Generic mfg.
Trial completion, Enrollment change, Trial primary completion date: The Most Appropriate Parameter Correlates With Clinical Effectiveness of Vancomycin: Trough Drug Concentration or Area Under Curve (AUC)/Minimum Inhibitory Concentration (MIC)? (clinicaltrials.gov) - Sep 5, 2014
P=N/A, N=123, Completed, Sponsor: National Taiwan University Hospital
Not yet recruiting --> Recruiting | Initiation date: May 2014 --> Sep 2014 | Trial primary completion date: Mar 2015 --> Aug 2015 Recruiting --> Completed | N=1500 --> 123 | Trial primary completion date: Nov 2014 --> Jun 2014
- | Vabomere (meropenem/vaborbactam) / Melinta Therap
Enrollment open: Efficacy, Safety, Tolerability of Vabomere Compared to Best Available Therapy in Treating Serious Infections in Adults (clinicaltrials.gov) - Sep 4, 2014
P3, N=150, Recruiting, Sponsor: Rempex Pharmaceuticals (a wholly owned subsidiary of The Medicines Company)
Recruiting --> Completed | N=1500 --> 123 | Trial primary completion date: Nov 2014 --> Jun 2014 Not yet recruiting --> Recruiting
- ||| Trial completion, Trial primary completion date: Rapid Identification and Susceptibility Testing of Pathogens From Blood Cultures (clinicaltrials.gov) - Sep 4, 2014
P=N/A, N=617, Completed, Sponsor: Mayo Clinic
Not yet recruiting --> Recruiting Active, not recruiting --> Completed | Trial primary completion date: May 2014 --> Aug 2014
- | Trial completion, Trial primary completion date: De-escalation of Empirical Antimicrobial Therapy Study in Severe Sepsis (clinicaltrials.gov) - Sep 4, 2014
P3, N=120, Completed, Sponsor: Assistance Publique Hopitaux De Marseille
Active, not recruiting --> Completed | Trial primary completion date: May 2014 --> Aug 2014 Recruiting --> Completed | Trial primary completion date: Oct 2013 --> Apr 2013
- Trial completion: Effect of Lipopolysaccharide on Skeletal Muscle Functions (clinicaltrials.gov) - Sep 4, 2014
P=N/A, N=6, Completed, Sponsor: University of Nottingham
Recruiting --> Completed | Trial primary completion date: Oct 2013 --> Apr 2013 Recruiting --> Completed
- Trial completion, Enrollment change: Ninj1: The Role of Ninjurin-1 During Systemic Inflammation (clinicaltrials.gov) - Sep 4, 2014
P=N/A, N=30, Completed, Sponsor: Dr. Patrick Meybohm, M.D.
Recruiting --> Completed Recruiting --> Completed | N=18 --> 30
- | Trial suspension: SAFEbt: S.A.F.E.BT System Extracorporeal Treatment With DIAPACT CRRT (clinicaltrials.gov) - Aug 27, 2014
P2, N=120, Suspended, Sponsor: B. Braun Medical Inc.
Recruiting --> Completed | N=18 --> 30 Recruiting --> Suspended
- Enrollment change, Trial termination, Trial primary completion date: Probiotics for Prevention Neonatal Infection (clinicaltrials.gov) - Aug 26, 2014
P2/3, N=4556, Terminated, Sponsor: University of Nebraska
Recruiting --> Suspended N=8442 --> 4556 | Recruiting --> Terminated | Trial primary completion date: Jan 2012 --> Jun 2012; DSMB stopped the study due to early effectiveness
- Trial completion: Lactoferrin Prophylaxis in VLBW and Regulator T-cells (clinicaltrials.gov) - Aug 26, 2014
P=N/A, N=60, Completed, Sponsor: Ankara University
N=8442 --> 4556 | Recruiting --> Terminated | Trial primary completion date: Jan 2012 --> Jun 2012; DSMB stopped the study due to early effectiveness Recruiting --> Completed
- Enrollment change, Trial primary completion date: Does Detailed Informed Consent for Cardiopulmonary Resuscitation and Mechanical Ventilation Impact Patients' Decisions and Outcomes? (clinicaltrials.gov) - Aug 25, 2014
P=N/A, N=200, Not yet recruiting, Sponsor: Jewish Hospital, Cincinnati, Ohio
Recruiting --> Completed N=100 --> 200 | Trial primary completion date: Oct 2013 --> Nov 2014
- Enrollment closed: Intensive Care - GLObal Study on Severe Acute Respiratory Infection (clinicaltrials.gov) - Aug 21, 2014
P=N/A, N=4000, Active, not recruiting, Sponsor: European Society of Intensive Care Medicine
N=100 --> 200 | Trial primary completion date: Oct 2013 --> Nov 2014 Recruiting --> Active, not recruiting
- Trial completion: International Multicentre Prevalence Study on Sepsis (clinicaltrials.gov) - Aug 21, 2014
P=N/A, N=1000, Completed, Sponsor: European Society of Intensive Care Medicine
Recruiting --> Active, not recruiting Recruiting --> Completed
- Trial primary completion date: UARK 2009-99 A Non-interventional Observational Study of Infectious Complications in Cancer Patients (clinicaltrials.gov) - Aug 21, 2014
P=N/A, N=600, Recruiting, Sponsor: University of Arkansas
Recruiting --> Completed Trial primary completion date: Nov 2014 --> Dec 2015
- | chlorhexidine gluconate / Generic mfg.
New P4 trial: Bacteremia in Periodontal Patients (clinicaltrials.gov) - Aug 15, 2014
P4, N=80, Completed, Sponsor: University of Taubate
- Enrollment open: The Paediatric Refill Study (PRefill) (clinicaltrials.gov) - Aug 15, 2014
P=N/A, N=135, Recruiting, Sponsor: University of Nottingham
Trial primary completion date: Nov 2014 --> Dec 2015 Not yet recruiting --> Recruiting
- Neo-Synephrine (phenylephrine hydrochloride ophthalmic solution) / Paragon BioTeck, Bausch Health, Akorn
Enrollment open: Phenylephrine Versus Norepinephrine for Septic Shock in Critically Ill Patients (clinicaltrials.gov) - Aug 15, 2014
P4, N=75, Recruiting, Sponsor: Vanderbilt University
Not yet recruiting --> Recruiting Not yet recruiting --> Recruiting
- Trial completion: Cord Blood 25(oh)-Vitamin D Level in Preterm Infants and Associated Morbidities (clinicaltrials.gov) - Aug 12, 2014
P=N/A, N=81, Completed, Sponsor: Dr. Sami Ulus Children's Hospital
Not yet recruiting --> Recruiting Recruiting --> Completed
- meropenem / Generic mfg.
New P4 trial: Population Pharmacokinetics and Monte Carlo Dosing Simulations of Meropenem During the Early Phase of Severe Sepsis and Septic Shock in Critically Ill Patients in Intensive Care Units (clinicaltrials.gov) - Aug 11, 2014
P4, N=9, Completed, Sponsor: Sutep Jaruratanasirikul
- Enrollment open: SIFT: Speed of Increasing Milk Feeds Trial (clinicaltrials.gov) - Aug 7, 2014
P=N/A, N=2500, Recruiting, Sponsor: University of Oxford
Recruiting --> Completed Not yet recruiting --> Recruiting
- vancomycin / Generic mfg.
Clinical: RCT of Continuous Versus Intermittent Infusion of Vancomycin in Neonates (clinicaltrials.gov) - Aug 6, 2014
P=N/A, N=200, Not yet recruiting, Sponsor: Murdoch Childrens Research Institute
- Clinical: The Paediatric Refill Study (PRefill) (clinicaltrials.gov) - Aug 5, 2014
P=N/A, N=135, Not yet recruiting, Sponsor: University of Nottingham
- || New P3 trial: RGNOSIS: Ecological Effects of Decolonisation Strategies in Intensive Care (clinicaltrials.gov) - Aug 4, 2014
P3, N=10700, Recruiting, Sponsor: MJM Bonten
- Phase classification: Chlorhexidine Vaginal and Infant Wash in Pakistan (clinicaltrials.gov) - Aug 1, 2014
P3, N=5008, Completed, Sponsor: NICHD Global Network for Women's and Children's Health
Not yet recruiting --> Recruiting Phase classification: P=N/A --> P3
- | Trial completion: Chlorhexidine Vaginal and Infant Wash in Pakistan (clinicaltrials.gov) - Jul 31, 2014
P3, N=5008, Completed, Sponsor: NICHD Global Network for Women's and Children's Health
Phase classification: P=N/A --> P3 Recruiting --> Completed
- Clinical: PRODA: Procalcitonin-guided Treatment on Duration of Antibiotic Therapy and Cost in Septic Patients (clinicaltrials.gov) - Jul 30, 2014
P=N/A, N=50, Not yet recruiting, Sponsor: Seoul National University Hospital
- Ventavis (iloprost) / Bayer, J&J, University of Copenhagen, Integrilin (eptifibatide) / Takeda
New P2 trial: CO-ILEPSS: Co-administration of Iloprost and Eptifibatide in Septic Shock Patients (clinicaltrials.gov) - Jul 30, 2014
P2, N=18, Not yet recruiting, Sponsor: Sisse R. Ostrowski, MD PhD DMSc
- ||| Enrollment open: Study to Evaluate the Effectiveness of the Initial Specimen Diversion Device (clinicaltrials.gov) - Jul 30, 2014
P=N/A, N=5308, Recruiting, Sponsor: Magnolia Medical Technologies, Inc.
Recruiting --> Completed Not yet recruiting --> Recruiting
- | Neo-Synephrine (phenylephrine hydrochloride ophthalmic solution) / Paragon BioTeck, Bausch Health, Akorn
New P4 trial: Phenylephrine Versus Norepinephrine for Septic Shock in Critically Ill Patients (clinicaltrials.gov) - Jul 30, 2014
P4, N=75, Not yet recruiting, Sponsor: Vanderbilt University
- midazolam hydrochloride / Generic mfg., dexmedetomidine / Generic mfg.
Clinical: The Effect of Dexmedetomidine on Microcirculation in Severe Sepsis (clinicaltrials.gov) - Jul 27, 2014
P4, N=60, Recruiting, Sponsor: National Taiwan University Hospital
Not yet recruiting --> Recruiting Not yet recruiting --> Recruiting | Initiation date: Apr 2014 --> Jul 2014
- furosemide / Generic mfg.
Enrollment change, Trial termination, Trial primary completion date: SPARK: Furosemide in Early Acute Kidney Injury (clinicaltrials.gov) - Jul 24, 2014
P2/3, N=72, Terminated, Sponsor: University of Alberta
Not yet recruiting --> Recruiting | Initiation date: Apr 2014 --> Jul 2014 N=216 --> 72 | Recruiting --> Terminated | Trial primary completion date: Dec 2013 --> Jul 2014; Feasibility of target enrollment within the context of available funding resources.
- ceftriaxone / Generic mfg.
Enrollment open, Trial initiation date, Trial primary completion date: PHANTASi: Prehospital Antibiotics Against Sepsis Trial (clinicaltrials.gov) - Jul 24, 2014
P=N/A, N=2200, Recruiting, Sponsor: VU University Medical Center
N=216 --> 72 | Recruiting --> Terminated | Trial primary completion date: Dec 2013 --> Jul 2014; Feasibility of target enrollment within the context of available funding resources. Not yet recruiting --> Recruiting | Initiation date: Mar 2014 --> Jun 2014 | Trial primary completion date: Mar 2016 --> Jun 2016
- Trial primary completion date: Phase I STEBVax in Healthy Adults (clinicaltrials.gov) - Jul 18, 2014
P1, N=29, Recruiting, Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Not yet recruiting --> Recruiting | Initiation date: Mar 2014 --> Jun 2014 | Trial primary completion date: Mar 2016 --> Jun 2016 Trial primary completion date: Mar 2014 --> Mar 2015
- |||| ceftaroline fosamil / Generic mfg.
Trial completion: Safety and Efficacy Study of Ceftaroline in Subjects With Staphylococcus Aureus Bacteremia or With Persistent Methicillin-Resistant Staphylococcus Aureus Bacteremia (clinicaltrials.gov) - Jul 17, 2014
P4, N=56, Completed, Sponsor: Cerexa, Inc.
Trial primary completion date: Mar 2014 --> Mar 2015 Active, not recruiting --> Completed
- ||| Clinical data, Trial completion, Preclinical: Clinical Outcomes in Candidemia Patients Based on in Vitro Susceptibility (clinicaltrials.gov) - Jul 16, 2014
P=N/A, N=450, Completed, Sponsor: University of Houston
Active, not recruiting --> Completed Active, not recruiting --> Completed
- |||| Trial completion, Enrollment change, Trial primary completion date: Post Marketing Surveillance Study To Observe Safety And Efficacy Of Eraxis® IV (clinicaltrials.gov) - Jul 16, 2014
P4, N=214, Completed, Sponsor: Pfizer
Active, not recruiting --> Completed Enrolling by invitation --> Completed | N=3000 --> 214 | Trial primary completion date: Jul 2014 --> Mar 2014
- | vancomycin / Generic mfg., trimethoprim/sulfamethoxazole / Generic mfg.
Enrollment closed: Cotrimoxazole Versus Vancomycin for Invasive Methicillin-resistant Staphylococcus Aureus Infections (clinicaltrials.gov) - Jul 15, 2014
P3, N=250, Active, not recruiting, Sponsor: Rabin Medical Center
Enrolling by invitation --> Completed | N=3000 --> 214 | Trial primary completion date: Jul 2014 --> Mar 2014 Recruiting --> Active, not recruiting