Respiratory Distress Syndrome, Adult News - LARVOL Sigma

Respiratory Distress Syndrome, Adult

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24 Mechanisms of Action

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|||||||||| Enrollment change, Metastases: Diffuse Acute Respiratory Distress Syndrome (ARDS), Recruitment Maneuver, and sRAGE (DAMAGE Study) (clinicaltrials.gov) - Sep 29, 2013
P4, N=24, Completed, Sponsor: University Hospital, Clermont-Ferrand
N=30 --> 24

|||||||||| Enrollment open: IVNICTUS: Early Non Invasive Ventilation in Immuno-compromized Patients With Acute Respiratory Failure. (clinicaltrials.gov) - Sep 16, 2013
P=N/A, N=374, Recruiting, Sponsor: Assistance Publique - H
N=30 --> 24 Not yet recruiting --> Recruiting

|||||||||| Trial completion, Surgery: SCRIPT: Seattle Cardiorenal Remote Ischemic Preconditioning Trial (clinicaltrials.gov) - Sep 15, 2013
P=N/A, N=90, Completed, Sponsor: Seattle Children's Hospital
Not yet recruiting --> Recruiting Recruiting --> Completed

|||||||||| Trial completion: Recruitment on Extravascular Lung Water in Acute Respiratory Distress Syndrome (ARDS) (clinicaltrials.gov) - Sep 12, 2013
P2, N=30, Completed, Sponsor: Chang Gung Memorial Hospital
Recruiting --> Completed Recruiting --> Completed

|||||||||| Enrollment open: Different Lipid Emulsions in Acute Lung Injury Patients (clinicaltrials.gov) - Sep 8, 2013
P4, N=30, Recruiting, Sponsor: B. Braun Melsungen AG
Recruiting --> Completed Not yet recruiting --> Recruiting

|||||||||| Trial completion: Low Dose Lung CT Scan for Quantitative Analysis in ARDS Patients (clinicaltrials.gov) - Aug 19, 2013
P=N/A, N=51, Completed, Sponsor: Policlinico Hospital
Not yet recruiting --> Recruiting Not yet recruiting --> Completed

|||||||||| Clinical: Intensive Nutrition in Acute Respiratory Distress Syndrome (ARDS): A Clinical Trial (INTACT) (clinicaltrials.gov) - Aug 11, 2013
P=N/A, N=200, Recruiting, Sponsor: University of Illinois at Chicago

|||||||||| Trial completion: Thoracic Fluid Content and Acute Lung Injury (clinicaltrials.gov) - Aug 11, 2013
P=N/A, N=22, Completed, Sponsor: National Taiwan University Hospital
Not yet recruiting --> Completed Not yet recruiting --> Completed

|||||||||| Enrollment change: Effect of Inhaled Nitric Oxide in Acute Chest Syndrome (INOSTA Study) (clinicaltrials.gov) - Jul 31, 2013
P2/3, N=100, Completed, Sponsor: Assistance Publique - Hôpitaux de Paris
Not yet recruiting --> Completed N=260 --> 100

|||||||||| Trial completion: Effect of Inhaled Nitric Oxide in Acute Chest Syndrome (INOSTA Study) (clinicaltrials.gov) - Jul 31, 2013
P2/3, N=100, Completed, Sponsor: Assistance Publique - Hôpitaux de Paris
N=260 --> 100 Recruiting --> Completed

|||||||||| Trial completion: Effects of Recruitment Maneuvers in Early Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS) Patients (clinicaltrials.gov) - Jul 31, 2013
P=N/A, N=120, Completed, Sponsor: LUN WEI LIU
Recruiting --> Completed Recruiting --> Completed

|||||||||| Enrollment open: LIPS-B: Lung Injury Prevention Study With Budesonide and Beta (clinicaltrials.gov) - Jul 23, 2013
P2, N=60, Recruiting, Sponsor: Mayo Clinic
Recruiting --> Completed Not yet recruiting --> Recruiting

|||||||||| Enrollment change, Video, Surgery: Low Tidal Volume and EVLWI During OLV (clinicaltrials.gov) - Jul 23, 2013
P1, N=39, Completed, Sponsor: Dammam University
Not yet recruiting --> Recruiting N=60 --> 39

|||||||||| Trial completion, Video, Surgery: Low Tidal Volume and EVLWI During OLV (clinicaltrials.gov) - Jul 23, 2013
P1, N=39, Completed, Sponsor: Dammam University
N=60 --> 39 Recruiting --> Completed

|||||||||| Enrollment open: Lung and Systemic Inflammation in the Critically Ill Patient (clinicaltrials.gov) - Jul 18, 2013
P=N/A, N=18, Recruiting, Sponsor: Rigshospitalet, Denmark
Recruiting --> Completed Not yet recruiting --> Recruiting

|||||||||| New P3 trial: ELASTANCE: Prospective Physiological Study of Lung Elastance in Recruitment and Derecruitment in Early Onset Mechanically Ventilated ARDS Patients (clinicaltrials.gov) - Jul 11, 2013
P3, N=12, Completed, Sponsor: Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer

|||||||||| Enrollment change: OPTIPEP: Optimization of Arterial Oxygen Transport by Positive End-expiratory Pressure Variation in Acute Respiratory Distress Syndrome (clinicaltrials.gov) - Jul 1, 2013
P=N/A, N=12, Completed, Sponsor: Rennes University Hospital
Not yet recruiting --> Recruiting N=20 --> 12

|||||||||| Trial completion: OPTIPEP: Optimization of Arterial Oxygen Transport by Positive End-expiratory Pressure Variation in Acute Respiratory Distress Syndrome (clinicaltrials.gov) - Jul 1, 2013
P=N/A, N=12, Completed, Sponsor: Rennes University Hospital
N=20 --> 12 Recruiting --> Completed

||||||||||  ticagrelor / Generic mfg.
New P1 trial:  XANTHIPPE: Targeting Platelet-Leukocyte Aggregates in Pneumonia With Ticagrelor (clinicaltrials.gov) -  Jun 19, 2013
P1, N=100, Recruiting,  Sponsor: University of Kentucky

|||||||||| Clinical: PRoVENT: Practice of Ventilation in Critically Ill Patients Without ARDS (clinicaltrials.gov) - Jun 2, 2013
P=N/A, N=1000, Not yet recruiting, Sponsor: Marcus J Schultz

|||||||||| Enrollment open: START: Human Mesenchymal Stem Cells For Acute Respiratory Distress Syndrome (clinicaltrials.gov) - May 28, 2013
P1, N=9, Recruiting, Sponsor: Michael A. Matthay
Recruiting --> Completed Not yet recruiting --> Recruiting

|||||||||| Trial completion: "VARIABLE-PSV" Study (clinicaltrials.gov) - May 27, 2013
P3, N=20, Completed, Sponsor: University Hospital, Montpellier
Not yet recruiting --> Recruiting Not yet recruiting --> Completed

|||||||||| Trial initiation date: Effects of Different Assisted Mechanical Ventilation in Acute Lung Injury/Acute Respiratory Distress Syndrome (ALI/ARDS) Patients: Pressure Support Ventilation (PSV), Neurally Adjusted Ventilatory Assist (NAVA) and Controlled by Patient (clinicaltrials.gov) - May 14, 2013
P=N/A, N=15, Not yet recruiting, Sponsor: Policlinico Hospital
Not yet recruiting --> Completed Initiation date: Aug 2012 --> Aug 2013

||||||||||  dilmapimod (SB-681323) / GSK
Trial completion:  SB-681323 IV for Subjects at Risk of Acute Lung Injury or ARDS (clinicaltrials.gov) -  Apr 10, 2013
P2, N=90, Completed,  Sponsor: GlaxoSmithKline
Initiation date: Aug 2012 --> Aug 2013 Recruiting --> Completed

|||||||||| Enrollment open: NUTRIREA2: Impact of Early Enteral vs. Parenteral Nutrition on Mortality in Patients Requiring Mechanical Ventilation and Catecholamines (clinicaltrials.gov) - Mar 20, 2013
P=N/A, N=2854, Recruiting, Sponsor: Centre Hospitalier Departemental Vendee
Recruiting --> Completed Not yet recruiting --> Recruiting

|||||||||| New P4 trial: Different Lipid Emulsions in Acute Lung Injury Patients (clinicaltrials.gov) - Mar 18, 2013
P4, N=30, Recruiting, Sponsor: B. Braun Melsungen AG

|||||||||| Trial completion, IO biomarker, Surgery: A Trial to Evaluate the Impact of Lung-protective Intervention in Patients Undergoing Esophageal Cancer Surgery (clinicaltrials.gov) - Mar 12, 2013
P=N/A, N=101, Completed, Sponsor: Shanghai Zhongshan Hospital
Not yet recruiting --> Recruiting Recruiting --> Completed

|||||||||| Trial completion, Metastases: Soluble Forms and Ligands of RAGE in ALI/ARDS (SoLiRAGE). (clinicaltrials.gov) - Mar 11, 2013
P=N/A, N=60, Completed, Sponsor: University Hospital, Clermont-Ferrand
Recruiting --> Completed Recruiting --> Completed

||||||||||  ALT 836 / ImmunityBio
Enrollment closed:  Anti-TF Antibody (ALT-836) to Treat Septic Patients With Acute Lung Injury or Acute Respiratory Distress Syndrome (clinicaltrials.gov) -  Mar 10, 2013
P2, N=150, Active, not recruiting,  Sponsor: Altor Bioscience Corporation
Recruiting --> Completed Completed --> Active, not recruiting

|||||||||| Enrollment closed: Extracorporeal Membrane Oxygenation (ECMO) in Non-intubated Patients With Acute Respiratory Distress Syndrome (ARDS) (clinicaltrials.gov) - Mar 8, 2013
P1/2, N=6, Active, not recruiting, Sponsor: Hannover Medical School
Completed --> Active, not recruiting Recruiting --> Active, not recruiting

||||||||||  Ventavis (iloprost) / Bayer, J&J, University of Copenhagen
Trial withdrawal:  Inhaled Iloprost as an Adjunct to Inhaled Nitric Oxide in Pediatric Critical Care Patients (clinicaltrials.gov) -  Mar 6, 2013
P1/2, N=0, Withdrawn,  Sponsor: Seattle Children's Hospital
Recruiting --> Active, not recruiting Recruiting --> Withdrawn

||||||||||  Ventavis (iloprost) / Bayer, J&J, University of Copenhagen
Enrollment change:  Inhaled Iloprost as an Adjunct to Inhaled Nitric Oxide in Pediatric Critical Care Patients (clinicaltrials.gov) -  Mar 6, 2013
P1/2, N=0, Withdrawn,  Sponsor: Seattle Children's Hospital
Recruiting --> Withdrawn N=40 --> 0

|||||||||| Enrollment open: Evaluation of the Lung Recruitment and End-expiratory Lung Collapse in Acute Respiratory Distress Syndrome (ARDS) (clinicaltrials.gov) - Mar 5, 2013
P=N/A, N=30, Recruiting, Sponsor: Policlinico Hospital
N=40 --> 0 Not yet recruiting --> Recruiting

|||||||||| Trial completion: PED-ALIEN: Incidence of Acute Lung Injury in Children (clinicaltrials.gov) - Feb 22, 2013
P=N/A, N=200, Completed, Sponsor: Dr. Negrin University Hospital
Not yet recruiting --> Recruiting Enrolling by invitation --> Completed

|||||||||| Trial termination: VVCCO2R: Venovenous CO2 Removal (VVCO2R) in Patients With COPD and Acute Respiratory Failure (clinicaltrials.gov) - Feb 10, 2013
P1/2, N=2, Terminated, Sponsor: The University of Texas, Galveston
Enrolling by invitation --> Completed Suspended --> Terminated; due to loss of key personnel due to illness and sabbatical of thePI

|||||||||| Enrollment open: RV STAR: Echocardiography Predictive of the Inefficacy and/or of the Unsafeness of Recruitment Maneuvers in Patients With Acute Respiratory Distress Syndrome. (clinicaltrials.gov) - Feb 7, 2013
P=N/A, N=50, Recruiting, Sponsor: Centre Hospitalier Universitaire de Besancon
Suspended --> Terminated; due to loss of key personnel due to illness and sabbatical of thePI Not yet recruiting --> Recruiting

||||||||||  dexmedetomidine / Generic mfg.
Trial completion:  Efficacy and Safety of Dexmedetomidine During Non-Invasive Positive Pressure Ventilation (clinicaltrials.gov) -  Feb 7, 2013
P2, N=36, Completed,  Sponsor: Tufts Medical Center
Not yet recruiting --> Recruiting Recruiting --> Completed

|||||||||| Enrollment open: ViPS: Variable Pressure Support Trial (clinicaltrials.gov) - Feb 6, 2013
P=N/A, N=228, Recruiting, Sponsor: Dresden University of Technology
Recruiting --> Completed Not yet recruiting --> Recruiting

|||||||||| New P2 trial: LIPS-B: Lung Injury Prevention Study With Budesonide and Beta (clinicaltrials.gov) - Feb 3, 2013
P2, N=60, Recruiting, Sponsor: Mayo Clinic

|||||||||| Trial completion: Weaning Using Noninvasive Positive Pressure Ventilation by Means of Helmet in Patients With Acute Respiratory Failure (clinicaltrials.gov) - Jan 29, 2013
P=N/A, N=250, Completed, Sponsor: University of Padova
Not yet recruiting --> Recruiting Recruiting --> Completed

|||||||||| New P1 trial: START: Human Mesenchymal Stem Cells For Acute Respiratory Distress Syndrome (clinicaltrials.gov) - Jan 23, 2013
P1, N=9, Recruiting, Sponsor: Michael A. Matthay

||||||||||  GSK1995057 / GSK
Enrollment change:  Safety Study of GSK1995057 Given as Single and Repeat Intravenous Doses in Healthy Subjects. (clinicaltrials.gov) -  Jan 16, 2013
P1, N=56, Completed,  Sponsor: GlaxoSmithKline
Recruiting --> Completed N=78 --> 56

||||||||||  GSK1995057 / GSK
Trial completion:  Safety Study of GSK1995057 Given as Single and Repeat Intravenous Doses in Healthy Subjects. (clinicaltrials.gov) -  Jan 16, 2013
P1, N=56, Completed,  Sponsor: GlaxoSmithKline
N=78 --> 56 Recruiting --> Completed

||||||||||  dexmedetomidine / Generic mfg.
Clinical:  Testing the Feasibility of Patient Controlled Sedation for Ventilated ICU Patients (clinicaltrials.gov) -  Jan 13, 2013
P1/2, N=40, Recruiting,  Sponsor: University of Minnesota - Clinical and Translational Science Institute
Recruiting --> Completed Initiation date: Jul 2012 --> Mar 2013

|||||||||| Enrollment closed: Long-Term Results in Mechanically Ventilated Individuals With Acute Lung Injury/Acute Respiratory Distress Syndrome (clinicaltrials.gov) - Jan 13, 2013
P=N/A, N=520, Active, not recruiting, Sponsor: National Heart, Lung, and Blood Institute (NHLBI)
Initiation date: Jul 2012 --> Mar 2013 Recruiting --> Active, not recruiting

|||||||||| New P1 trial, Video, Surgery: Low Tidal Volume and EVLWI During OLV (clinicaltrials.gov) - Jan 6, 2013
P1, N=39, Completed, Sponsor: Dammam University

|||||||||| Enrollment change: PET Imaging in Patients at Risk for Acute Lung Injury (clinicaltrials.gov) - Jan 2, 2013
P=N/A, N=5, Completed, Sponsor: Washington University School of Medicine
Recruiting --> Active, not recruiting N=10 --> 5

|||||||||| Trial completion: PET Imaging in Patients at Risk for Acute Lung Injury (clinicaltrials.gov) - Jan 2, 2013
P=N/A, N=5, Completed, Sponsor: Washington University School of Medicine
N=10 --> 5 Recruiting --> Completed

|||||||||| Trial completion: Interobserver Variation in Applying a Radiographic Definition for Acute Respiratory Distress Syndrome (ARDS) (clinicaltrials.gov) - Dec 19, 2012
P=N/A, N=286, Completed, Sponsor: Society of Critical Care Medicine, China
Recruiting --> Completed Recruiting --> Completed

|||||||||| Clinical data, Trial completion: Post-Hospital Case Management to Improve Clinical Outcomes in Individuals Requiring Mechanical Ventilation (clinicaltrials.gov) - Dec 17, 2012
P=N/A, N=600, Completed, Sponsor: University of Washington
Recruiting --> Completed Active, not recruiting --> Completed