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21 Companies |
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19 Products |
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19 Products |
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24 Mechanisms of Action |
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0 Trials |
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452 News |
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- | aspirin / Generic mfg.
Trial completion date, Trial termination, Trial primary completion date: ASpirin as a Treatment for ARDS (STAR): a Phase 2 Randomised Control Trial (clinicaltrials.gov) - Mar 13, 2019
P2, N=49, Terminated, Sponsor: Belfast Health and Social Care Trust
Trial completion date: Jul 2017 --> Nov 2018 | Enrolling by invitation --> Terminated | Trial primary completion date: Jul 2017 --> Nov 2018; Slow recruitment
- | midazolam hydrochloride / Generic mfg.
Trial completion: Pilot Study on Pairing Sedation Strategies and Weaning (clinicaltrials.gov) - Mar 13, 2019
P=N/A, N=90, Completed, Sponsor: MemorialCare Health System
Trial completion date: Jul 2017 --> Nov 2018 | Enrolling by invitation --> Terminated | Trial primary completion date: Jul 2017 --> Nov 2018; Slow recruitment Recruiting --> Completed
- | dexamethasone injection / Generic mfg.
Trial completion, Trial completion date, Trial primary completion date: DEXA-ARDS: Efficacy Study of Dexamethasone to Treat the Acute Respiratory Distress Syndrome (clinicaltrials.gov) - Feb 18, 2019
P4, N=277, Completed, Sponsor: Dr. Negrin University Hospital
Recruiting --> Completed Recruiting --> Completed | Trial completion date: Oct 2018 --> Feb 2019 | Trial primary completion date: Oct 2018 --> Feb 2019
- | Enrollment change, Trial completion date, Trial termination, Trial primary completion date: Clinical Trial of Nebulized Hypertonic Saline to Attenuate Post-Traumatic Acute Lung Injury (clinicaltrials.gov) - Dec 20, 2018
P1, N=13, Terminated, Sponsor: Denver Health and Hospital Authority
Recruiting --> Completed | Trial completion date: Oct 2018 --> Feb 2019 | Trial primary completion date: Oct 2018 --> Feb 2019 N=20 --> 13 | Trial completion date: May 2021 --> Nov 2018 | Recruiting --> Terminated | Trial primary completion date: May 2021 --> Nov 2018; low enrollment and loss of funding
- | Enrollment change, Trial completion date, Trial termination, Trial primary completion date: Lung and Systemic Inflammation in the Critically Ill Patient (clinicaltrials.gov) - Dec 12, 2018
P=N/A, N=8, Terminated, Sponsor: Rigshospitalet, Denmark
N=20 --> 13 | Trial completion date: May 2021 --> Nov 2018 | Recruiting --> Terminated | Trial primary completion date: May 2021 --> Nov 2018; low enrollment and loss of funding N=18 --> 8 | Trial completion date: Nov 2017 --> Dec 2018 | Recruiting --> Terminated | Trial primary completion date: Nov 2016 --> Dec 2018; Slow enrollment and therefore not possible to reach the estimated enrollment
- | Trial termination: PHARLAP: A Multi-centre Trial of an Open Lung Strategy Including Permissive Hypercapnia, Alveolar Recruitment and Low Airway Pressure in Patients With Acute Respiratory Distress Syndrome (clinicaltrials.gov) - Nov 28, 2018
P=N/A, N=115, Terminated, Sponsor: Australian and New Zealand Intensive Care Research Centre
N=18 --> 8 | Trial completion date: Nov 2017 --> Dec 2018 | Recruiting --> Terminated | Trial primary completion date: Nov 2016 --> Dec 2018; Slow enrollment and therefore not possible to reach the estimated enrollment Active, not recruiting --> Terminated; Halted by the Management Committee after the publication of the ART Trial
- | Trial primary completion date: Early Use of Noninvasive Positive Pressure Ventilation for Intro-pulmonary Acute Lung Injury (clinicaltrials.gov) - Nov 21, 2018
P=N/A, N=204, Completed, Sponsor: Beijing Hospital
Active, not recruiting --> Terminated; Halted by the Management Committee after the publication of the ART Trial Trial primary completion date: Jun 2013 --> Dec 2016
- | Enrollment change, Trial primary completion date: Noninvasive Positive Pressure Ventilation in Moderate Acute Respiratory Distress Syndrome (clinicaltrials.gov) - Nov 21, 2018
P=N/A, N=120, Completed, Sponsor: Beijing Hospital
Trial primary completion date: Jun 2013 --> Dec 2016 N=200 --> 120 | Trial primary completion date: Jul 2013 --> Dec 2016
- | Enrollment change: STANDARDS: Stratification of the Acute Respiratory Distress Syndrome (clinicaltrials.gov) - Oct 13, 2018
P=N/A, N=300, Completed, Sponsor: Dr. Negrin University Hospital
N=200 --> 120 | Trial primary completion date: Jul 2013 --> Dec 2016 N=600 --> 300
- | Phase classification: Effect Of Acute Inflammatory Mediators On Functional Limitations In Patients With Acute Respiratory Failure (clinicaltrials.gov) - Aug 15, 2018
P=N/A, N=100, Completed, Sponsor: Wake Forest University
N=600 --> 300 Phase classification: P1/2 --> P=N/A
- | dexamethasone injection / Generic mfg.
Trial completion date, Trial primary completion date: DEXA-ARDS: Efficacy Study of Dexamethasone to Treat the Acute Respiratory Distress Syndrome (clinicaltrials.gov) - Aug 1, 2018
P4, N=314, Recruiting, Sponsor: Dr. Negrin University Hospital
Phase classification: P1/2 --> P=N/A Trial completion date: Jun 2018 --> Oct 2018 | Trial primary completion date: Jun 2018 --> Oct 2018
- | Enrollment change, Trial completion date, Trial termination, Trial primary completion date: ViPS: Variable Pressure Support Trial (clinicaltrials.gov) - Jul 27, 2018
P=N/A, N=130, Terminated, Sponsor: Technische Universität Dresden
Trial completion date: Jun 2018 --> Oct 2018 | Trial primary completion date: Jun 2018 --> Oct 2018 N=228 --> 130 | Trial completion date: Aug 2017 --> Jan 2018 | Recruiting --> Terminated | Trial primary completion date: Aug 2017 --> Jan 2018; Rate of recruitment
- | Phase classification: Evaluation Of The Total Face Mask For Emergency Application In Acute Respiratory Failure (clinicaltrials.gov) - Jul 3, 2018
P=N/A, N=60, Completed, Sponsor: Tufts Medical Center
N=228 --> 130 | Trial completion date: Aug 2017 --> Jan 2018 | Recruiting --> Terminated | Trial primary completion date: Aug 2017 --> Jan 2018; Rate of recruitment Phase classification: P4 --> P=N/A
- | Trial completion, Stroma: Human Mesenchymal Stromal Cells For Acute Respiratory Distress Syndrome (START) (clinicaltrials.gov) - May 3, 2018
P2, N=60, Completed, Sponsor: Michael A. Matthay
Phase classification: P4 --> P=N/A Active, not recruiting --> Completed
- | dexmedetomidine / Generic mfg.
Enrollment change: Testing the Feasibility of Patient Controlled Sedation for Ventilated ICU Patients (clinicaltrials.gov) - Mar 13, 2018
P1/2, N=15, Completed, Sponsor: University of Minnesota - Clinical and Translational Science Institute
Active, not recruiting --> Completed N=38 --> 15
- | dexamethasone injection / Generic mfg.
Trial completion date, Trial primary completion date: DEXA-ARDS: Efficacy Study of Dexamethasone to Treat the Acute Respiratory Distress Syndrome (clinicaltrials.gov) - Feb 26, 2018
P4, N=314, Recruiting, Sponsor: Dr. Negrin University Hospital
N=38 --> 15 Trial primary completion date: Dec 2017 --> Jun 2018 | Trial completion date: Dec 2017 --> Jun 2018
- | Trial completion, Trial primary completion date: EDDRAPro: Time-motion-mode Ultrasound Diaphragm Measures in Patients With Acute Respiratory Distress in Emergency Department (clinicaltrials.gov) - Jan 3, 2018
P=N/A, N=104, Completed, Sponsor: Centre Hospitalier Universitaire de Nīmes
Trial primary completion date: Dec 2017 --> Jun 2018 | Trial completion date: Dec 2017 --> Jun 2018 Recruiting --> Completed | Trial primary completion date: Apr 2017 --> Sep 2017
- | dexmedetomidine / Generic mfg.
New P2 trial: Efficacy and Safety of Dexmedetomidine During Non-Invasive Positive Pressure Ventilation (clinicaltrials.gov) - Dec 20, 2017
P2, N=36, Completed, Sponsor: Tufts Medical Center
- ||| Trial completion, Enrollment change: EOLIA: Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome (clinicaltrials.gov) - Nov 30, 2017
P=N/A, N=249, Completed, Sponsor: Assistance Publique - Hôpitaux de Paris
Recruiting --> Completed | Trial primary completion date: Apr 2017 --> Sep 2017 Recruiting --> Completed | N=331 --> 249
- | Enrollment closed, Enrollment change: PHARLAP: A Multi-centre Trial of an Open Lung Strategy Including Permissive Hypercapnia, Alveolar Recruitment and Low Airway Pressure in Patients With Acute Respiratory Distress Syndrome (clinicaltrials.gov) - Nov 21, 2017
P=N/A, N=115, Active, not recruiting, Sponsor: Australian and New Zealand Intensive Care Research Centre
Recruiting --> Completed | N=331 --> 249 Recruiting --> Active, not recruiting | N=340 --> 115
- | Enrollment change, Trial withdrawal: Airway Inflammatory Response During Illness in Children With Respiratory Failure (clinicaltrials.gov) - Nov 14, 2017
P=N/A, N=0, Withdrawn, Sponsor: University of North Carolina, Chapel Hill
Recruiting --> Active, not recruiting | N=340 --> 115 N=20 --> 0 | Not yet recruiting --> Withdrawn
- | Enrollment change: Weaning From Mechanical Ventilation Using Permissive Hypercarbia (clinicaltrials.gov) - Oct 20, 2017
P=N/A, N=3, Terminated, Sponsor: Milton S. Hershey Medical Center
N=20 --> 0 | Not yet recruiting --> Withdrawn N=40 --> 3
- | Enrollment change, Trial primary completion date: Strain and Blood Inflammatory Markers as Prognostic Tools for ARDS AMIS (ARDS - Markers of Inflammation - Strain) (clinicaltrials.gov) - Oct 5, 2017
P=N/A, N=6, Terminated, Sponsor: Centre Hospitalier Universitaire de Nice
N=40 --> 3 N=20 --> 6 | Trial primary completion date: Oct 2014 --> Oct 2017
- | Biomarker, Enrollment change, Trial termination, Trial primary completion date: Acute Lung Injury Ventilator Evaluation (ALIVE) (clinicaltrials.gov) - Sep 28, 2017
P=N/A, N=4, Terminated, Sponsor: University of Wisconsin, Madison
N=20 --> 6 | Trial primary completion date: Oct 2014 --> Oct 2017 N=100 --> 4 | Recruiting --> Terminated | Trial primary completion date: Nov 2017 --> Oct 2014; Lead Investigator no longer at Institution
- H.P. Acthar Gel (repository corticotropin injection) / Mallinckrodt
Trial primary completion date: Safety and Efficacy Study of Acthar in Subjects With ARDS (clinicaltrials.gov) - Sep 27, 2017
P2, N=0, Withdrawn, Sponsor: Mallinckrodt
N=100 --> 4 | Recruiting --> Terminated | Trial primary completion date: Nov 2017 --> Oct 2014; Lead Investigator no longer at Institution Trial primary completion date: Oct 2014 --> Aug 2016
- | midazolam hydrochloride / Generic mfg.
Trial primary completion date: Pilot Study on Pairing Sedation Strategies and Weaning (clinicaltrials.gov) - Sep 15, 2017
P=N/A, N=90, Recruiting, Sponsor: MemorialCare Health System
Trial primary completion date: Oct 2014 --> Aug 2016 Trial primary completion date: Apr 2016 --> Apr 2018
- |||| Valcyte (valganciclovir) / Roche, Mitsubishi Tanabe, Cytovene (ganciclovir) / Roche
Trial completion, Trial initiation date: GRAIL: Ganciclovir/Valganciclovir for Prevention of CMV Reactivation in Acute Injury of the Lung and Respiratory Failure (clinicaltrials.gov) - Sep 13, 2017
P2, N=160, Completed, Sponsor: Fred Hutchinson Cancer Research Center
Trial primary completion date: Apr 2016 --> Apr 2018 Active, not recruiting --> Completed | Initiation date: Sep 2011 --> Mar 2011
- | Trial completion, Enrollment change: Muscle Ultrasound Signifies Condition Upgrade Leading Approach to Recovery (clinicaltrials.gov) - Aug 15, 2017
P=N/A, N=1, Completed, Sponsor: Wake Forest University Health Sciences
Active, not recruiting --> Completed | Initiation date: Sep 2011 --> Mar 2011 Recruiting --> Completed | N=30 --> 1
- | Trial completion: SUPERNOVA: Strategy of UltraProtective Lung Ventilation With Extracorporeal CO2 Removal for New-Onset Moderate to seVere ARDS (clinicaltrials.gov) - Aug 4, 2017
P1/2, N=95, Completed, Sponsor: European Society of Intensive Care Medicine
Recruiting --> Completed | N=30 --> 1 Recruiting --> Completed
- | dexamethasone injection / Generic mfg.
Trial primary completion date: DEXA-ARDS: Efficacy Study of Dexamethasone to Treat the Acute Respiratory Distress Syndrome (clinicaltrials.gov) - Jul 26, 2017
P4, N=314, Recruiting, Sponsor: Dr. Negrin University Hospital
Recruiting --> Completed Trial primary completion date: May 2017 --> Dec 2017
- ||| Trial completion, Trial primary completion date: RINO: Impact of Nasal High-flow vs Venturi Mask Oxygen Therapy on Weaning Outcome: a Multicenter, Randomized, Controlled Trial (clinicaltrials.gov) - Jul 21, 2017
P=N/A, N=500, Completed, Sponsor: Catholic University of the Sacred Heart
Trial primary completion date: May 2017 --> Dec 2017 Active, not recruiting --> Completed | Trial primary completion date: Mar 2017 --> Oct 2016
- || GSK1995057 / GSK
Trial primary completion date: Safety Study of GSK1995057 Given as Single and Repeat Intravenous Doses in Healthy Subjects. (clinicaltrials.gov) - Jun 12, 2017
P1, N=56, Completed, Sponsor: GlaxoSmithKline
Active, not recruiting --> Completed | Trial primary completion date: Mar 2017 --> Oct 2016 Trial primary completion date: Mar 2012 --> Jun 2012
- | Trial completion, Phase classification, Trial primary completion date: AirconVAP: Effects of Airway Conditioning Devices on Ventilator Associated Pneumonia:a Randomized Clinical Trial (clinicaltrials.gov) - May 25, 2017
P=N/A, N=190, Completed, Sponsor: Università degli Studi dell'Insubria
Trial primary completion date: Mar 2012 --> Jun 2012 Trial primary completion date: May 2011 --> Mar 2015 | Recruiting --> Completed | Phase classification: P4 --> PN/A
- | Trial termination, Trial primary completion date: SmartCare Driven Pressure Support-Non Invasive Ventilation Feasibility Study (clinicaltrials.gov) - May 8, 2017
P=N/A, N=11, Terminated, Sponsor: University of Lausanne Hospitals
Trial primary completion date: May 2011 --> Mar 2015 | Recruiting --> Completed | Phase classification: P4 --> PN/A Recruiting --> Terminated | Trial primary completion date: Sep 2015 --> Aug 2016; Enough data to conclude
- | Trial completion, Enrollment change, Trial primary completion date: Effect of Variable PSV in Acute Lung Injury: Part I and Part II (clinicaltrials.gov) - May 3, 2017
P=N/A, N=20, Completed, Sponsor: University of Genova
Recruiting --> Terminated | Trial primary completion date: Sep 2015 --> Aug 2016; Enough data to conclude Recruiting --> Completed | N=16 --> 20 | Trial primary completion date: Aug 2016 --> Dec 2016
- | Enrollment closed, Stroma: Human Mesenchymal Stromal Cells For Acute Respiratory Distress Syndrome (START) (clinicaltrials.gov) - May 3, 2017
P2, N=60, Active, not recruiting, Sponsor: Michael A. Matthay
Recruiting --> Completed | N=16 --> 20 | Trial primary completion date: Aug 2016 --> Dec 2016 Recruiting --> Active, not recruiting
- | Enrollment change, Trial termination, Trial primary completion date: Effects of Oxygen on Lung Tissue During Anesthesia (clinicaltrials.gov) - Apr 20, 2017
P=N/A, N=10, Terminated, Sponsor: Vanderbilt University
Recruiting --> Active, not recruiting N=40 --> 10 | Active, not recruiting --> Terminated | Trial primary completion date: Jun 2009 --> Sep 2008; poor enrollment
- | Trial completion, Enrollment change, Trial primary completion date: Early Insulin and Development of ARDS (clinicaltrials.gov) - Apr 10, 2017
P2, N=18, Completed, Sponsor: Albert Einstein College of Medicine, Inc.
N=40 --> 10 | Active, not recruiting --> Terminated | Trial primary completion date: Jun 2009 --> Sep 2008; poor enrollment Active, not recruiting --> Completed | N=90 --> 18 | Trial primary completion date: Sep 2012 --> Dec 2011
- | Trial termination: I-TRIGER: INR-Triggered Transfusion In GI Bleeders From ER (clinicaltrials.gov) - Mar 27, 2017
P3, N=50, Terminated, Sponsor: University of Colorado, Denver
Active, not recruiting --> Completed | N=90 --> 18 | Trial primary completion date: Sep 2012 --> Dec 2011 Active, not recruiting --> Terminated
- || Trial primary completion date: EOLIA: Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome (clinicaltrials.gov) - Mar 22, 2017
P=N/A, N=331, Recruiting, Sponsor: Assistance Publique - Hôpitaux de Paris
Active, not recruiting --> Terminated Trial primary completion date: Feb 2017 --> Jul 2017
- | Biomarker, Trial completion: IFRA2: Validation of the Percentage of Alveolar Fibrocyte as Biomarker During ARDS (clinicaltrials.gov) - Mar 22, 2017
P=N/A, N=84, Completed, Sponsor: Assistance Publique - Hôpitaux de Paris
Trial primary completion date: Feb 2017 --> Jul 2017 Active, not recruiting --> Completed
- | Enrollment change: Effect of Low Tidal Volume Ventilation in Improving Oxygenation and Thus Reducing Acute Lung Injury in the Cardiac Surgical Patient (clinicaltrials.gov) - Mar 17, 2017
P=N/A, N=150, Completed, Sponsor: Beth Israel Deaconess Medical Center
Active, not recruiting --> Completed N=120 --> 150
- | Phase classification: Variable Ventilation During Acute Respiratory Failure (clinicaltrials.gov) - Mar 17, 2017
P=N/A, N=7, Terminated, Sponsor: Boston Medical Center
N=120 --> 150 Phase classification: P1 --> P=N/A
- | Trial primary completion date: SUPERNOVA: Strategy of UltraProtective Lung Ventilation With Extracorporeal CO2 Removal for New-Onset Moderate to seVere ARDS (clinicaltrials.gov) - Mar 14, 2017
P1/2, N=100, Recruiting, Sponsor: European Society of Intensive Care Medicine
Phase classification: P1 --> P=N/A Trial primary completion date: Dec 2016 --> May 2017
- | Phase classification: Mechanical Ventilation, Directed by Esophageal Pressure Measurements, in Patients With Acute Lung Injury (clinicaltrials.gov) - Feb 27, 2017
P=N/A, N=63, Completed, Sponsor: Beth Israel Deaconess Medical Center
Trial primary completion date: Dec 2016 --> May 2017 Phase classification: P2/3 --> P=N/A
- | Phase classification: EOLIA: Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome (clinicaltrials.gov) - Feb 8, 2017
P=N/A, N=331, Recruiting, Sponsor: Assistance Publique - Hôpitaux de Paris
Phase classification: P2/3 --> P=N/A Phase classification: P3 --> P=N/A
- Trial initiation date, Trial primary completion date: Airway Inflammatory Response During Illness in Children With Respiratory Failure (clinicaltrials.gov) - Feb 3, 2017
P=N/A, N=20, Not yet recruiting, Sponsor: University of North Carolina, Chapel Hill
Phase classification: P3 --> P=N/A Initiation date: Apr 2015 --> Jul 2017 | Trial primary completion date: Mar 2017 --> Aug 2019
- Trial completion: Electrical Impedance Imaging of Patients on Mechanical Ventilation (clinicaltrials.gov) - Feb 1, 2017
P=N/A, N=2, Completed, Sponsor: Colorado State University
Initiation date: Apr 2015 --> Jul 2017 | Trial primary completion date: Mar 2017 --> Aug 2019 Recruiting --> Completed
- Trial completion, Enrollment change, Trial primary completion date: RV STAR: Echocardiography Predictive of the Inefficacy and/or of the Unsafeness of Recruitment Maneuvers in Patients With Acute Respiratory Distress Syndrome. (clinicaltrials.gov) - Jan 31, 2017
P=N/A, N=30, Completed, Sponsor: Centre Hospitalier Universitaire de Besancon
Recruiting --> Completed Recruiting --> Completed | N=50 --> 30 | Trial primary completion date: Apr 2016 --> Jan 2017
- || Enrollment closed, Trial primary completion date: RINO: Impact of Nasal High-flow vs Venturi Mask Oxygen Therapy on Weaning Outcome: a Multicenter, Randomized, Controlled Trial (clinicaltrials.gov) - Jan 31, 2017
P=N/A, N=500, Active, not recruiting, Sponsor: Catholic University of the Sacred Heart
Recruiting --> Completed | N=50 --> 30 | Trial primary completion date: Apr 2016 --> Jan 2017 Recruiting --> Active, not recruiting | Trial primary completion date: Aug 2016 --> Mar 2017