Pre-Eclampsia News - LARVOL Sigma

Pre-Eclampsia

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13 Mechanisms of Action

||||||||||  enoxaparin sodium / Generic mfg.
Enrollment change:  HEPEPE: Prevention of Maternal and Perinatal Complications by Enoxaparin in Women With Previous Severe Preeclampsia (clinicaltrials.gov) -  Aug 4, 2013
P3, N=255, Recruiting,  Sponsor: Assistance Publique - H
N=440 --> 255

||||||||||  nifedipine immediate release / Generic mfg., labetalol / Generic mfg.
New P4 trial:  Oral Antihypertensive Regimens for Management of Hypertension in Pregnancy (clinicaltrials.gov) -  Jul 29, 2013
P4, N=671, Recruiting,  Sponsor: Gynuity Health Projects

||||||||||  captopril / Generic mfg., clonidine / Generic mfg.
Trial completion:  CLONCAP: Clonidine Versus Captopril for Treatment of Postpartum Very High Blood Pressure (clinicaltrials.gov) -  Jul 24, 2013
P4, N=90, Completed,  Sponsor: Instituto Materno Infantil Prof. Fernando Figueira
N=440 --> 255 Recruiting --> Completed

|||||||||| Trial completion: Circulating Oxidative Stress and Gestational Hypertension. Study of the Evolution of Free-radical Markers of Oxidative Stress From Before to After Childbirth in Two Groups of Women: Normal Pregnancy and Pre-eclampsia. (clinicaltrials.gov) - Jul 21, 2013
P=N/A, N=120, Completed, Sponsor: Centre Hospitalier Universitaire Dijon
Recruiting --> Completed Not yet recruiting --> Completed

|||||||||| Enrollment open: Urine-plasminogen as a Predictor for Development Of Preeclampsia in Pregnant Women With Type 1 Diabetes Mellitus (clinicaltrials.gov) - Jul 2, 2013
P=N/A, N=130, Recruiting, Sponsor: Odense University Hospital
Not yet recruiting --> Completed Not yet recruiting --> Recruiting

|||||||||| Trial initiation date: RAAPID-II: Removal of Anti-Angiogenic Proteins in Preeclampsia Before Delivery (clinicaltrials.gov) - Jun 23, 2013
P1/2, N=12, Recruiting, Sponsor: Massachusetts General Hospital
Not yet recruiting --> Recruiting Initiation date: Mar 2013 --> Jun 2013

|||||||||| Enrollment closed: The CHIPS Trial (Control of Hypertension In Pregnancy Study) (clinicaltrials.gov) - May 30, 2013
P=N/A, N=1028, Active, not recruiting, Sponsor: University of British Columbia
Initiation date: Mar 2013 --> Jun 2013 Recruiting --> Active, not recruiting

||||||||||  Reasanz (serelaxin) / Novartis
Enrollment open:  Safety and Efficacy of RLX030 in Pregnant Women With Pre- Eclampsia (clinicaltrials.gov) -  May 22, 2013
P2, N=60, Recruiting,  Sponsor: Novartis Pharmaceuticals
Recruiting --> Active, not recruiting Not yet recruiting --> Recruiting

|||||||||| New P3 trial: New Magnesium Sulphate Protocol for Pre-eclampsia (clinicaltrials.gov) - May 1, 2013
P3, N=240, Completed, Sponsor: Cairo University

|||||||||| Enrollment closed: A Study to Evaluate the Use of Placenta Protein 13 (PP13) in the First Trimester of Pregnancy as a Diagnostic Aiding Tool in the Assessment of the Risk for Developing Preeclampsia in Women With Low and Unknown Risk (clinicaltrials.gov) - Apr 17, 2013
P=N/A, N=2000, Active, not recruiting, Sponsor: Carl Weiner, MD
Not yet recruiting --> Recruiting Recruiting --> Active, not recruiting

|||||||||| Biomarker, Enrollment closed, Adverse events: Placental Growth and Adverse Pregnancy Outcomes (clinicaltrials.gov) - Apr 2, 2013
P=N/A, N=1200, Active, not recruiting, Sponsor: University of Pennsylvania
Recruiting --> Active, not recruiting Recruiting --> Active, not recruiting

|||||||||| Trial completion: MorbiMortality Amelioration in Preeclamptic Primiparas Study. MoMA Pre Prim Study (clinicaltrials.gov) - Mar 25, 2013
P=N/A, N=1040, Completed, Sponsor: Assistance Publique - H
Recruiting --> Active, not recruiting Active, not recruiting --> Completed

|||||||||| Enrollment open: RAAPID-II: Removal of Anti-Angiogenic Proteins in Preeclampsia Before Delivery (clinicaltrials.gov) - Mar 21, 2013
P1/2, N=12, Recruiting, Sponsor: Massachusetts General Hospital
Active, not recruiting --> Completed Withheld --> Recruiting

|||||||||| New P3 trial: Induction With Foley OR Misoprostol (INFORM) Study (clinicaltrials.gov) - Feb 26, 2013
P3, N=602, Not yet recruiting, Sponsor: University of Liverpool

||||||||||  thyroxine / Generic mfg.
Enrollment open:  Selenium Supplementation in Pregnancy (clinicaltrials.gov) -  Feb 18, 2013
P4, N=150, Recruiting,  Sponsor: University of Roma La Sapienza
Withheld --> Recruiting Not yet recruiting --> Recruiting

|||||||||| Biomarker, Trial completion: DIP: Detection and Identification of Preeclampsia Via Volatile Biomarkers (clinicaltrials.gov) - Feb 4, 2013
P=N/A, N=90, Completed, Sponsor: The Nazareth Hospital, Israel
Not yet recruiting --> Recruiting Recruiting --> Completed

||||||||||  remifentanil / Generic mfg., dexmedetomidine / Generic mfg.
Intubation:  Dexmedetomidine vs. Remifentanil for Pre-eclampsia During Caesarean Delivery (clinicaltrials.gov) -  Jan 9, 2013
P2, N=36, Recruiting,  Sponsor: Mansoura University

||||||||||  captopril / Generic mfg., clonidine / Generic mfg.
New P4 trial:  CLONCAP: Clonidine Versus Captopril for Treatment of Postpartum Very High Blood Pressure (clinicaltrials.gov) -  Jan 3, 2013
P4, N=90, Completed,  Sponsor: Instituto Materno Infantil Prof. Fernando Figueira

|||||||||| Trial completion: CoPPer Study - Complications of Polycystic Ovary Syndrome (PCOS) Pregnancy: Evaluating Risk (clinicaltrials.gov) - Dec 18, 2012
P=N/A, N=300, Completed, Sponsor: UMC Utrecht
Recruiting --> Completed Recruiting --> Completed

||||||||||  aspirin / Generic mfg.
New P4 trial:  PERASTUN: Prevention of Pre-eclampsia and SGA by Low-Dose Aspirin in Nulliparous Women With Abnormal First-trimester Uterine Artery Dopplers (clinicaltrials.gov) -  Nov 18, 2012
P4, N=4972, Recruiting,  Sponsor: University Hospital, Tours

|||||||||| Enrollment change: Goal-Directed Therapy in Pregnant Women at High Risk of Developing Preeclampsia (clinicaltrials.gov) - Nov 7, 2012
P=N/A, N=20, Completed, Sponsor: Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Recruiting --> Completed N=30 --> 20

|||||||||| Trial completion: Goal-Directed Therapy in Pregnant Women at High Risk of Developing Preeclampsia (clinicaltrials.gov) - Nov 7, 2012
P=N/A, N=20, Completed, Sponsor: Samuel Lunenfeld Research Institute, Mount Sinai Hospital
N=30 --> 20 Recruiting --> Completed

|||||||||| Enrollment open: Improving Maternal and Child Health in India: Evaluating Demand and Supply Side Strategies (IMATCHINE) (clinicaltrials.gov) - Oct 14, 2012
P=N/A, N=14990, Recruiting, Sponsor: Duke University
Recruiting --> Completed Not yet recruiting --> Recruiting

|||||||||| Enrollment closed, Adverse events: Predicting Complications in Women With Toxaemia (clinicaltrials.gov) - Oct 3, 2012
P=N/A, N=2000, Active, not recruiting, Sponsor: University of British Columbia
Not yet recruiting --> Recruiting Recruiting --> Active, not recruiting

|||||||||| Enrollment change: Early Pregnancy Antioxidant Supplementation in the Prevention of Preeclampsia (clinicaltrials.gov) - Oct 2, 2012
P=N/A, N=684, Completed, Sponsor: University of Mississippi Medical Center
Recruiting --> Active, not recruiting N=300 --> 684

|||||||||| Trial completion: Early Pregnancy Antioxidant Supplementation in the Prevention of Preeclampsia (clinicaltrials.gov) - Oct 2, 2012
P=N/A, N=684, Completed, Sponsor: University of Mississippi Medical Center
N=300 --> 684 Active, not recruiting --> Completed

|||||||||| New P2 trial: Effect of Methyldopa on Uterine Artery Diameter in Pregnant Women With Mild Preeclampsia (clinicaltrials.gov) - Aug 26, 2012
P2, N=50, Completed, Sponsor: Isfahan University of Medical Sciences

|||||||||| Trial initiation date: Restless Leg Syndrome and Severe Preeclampsia (clinicaltrials.gov) - Aug 12, 2012
P=N/A, N=310, Recruiting, Sponsor: Saint Thomas Hospital, Panama
Active, not recruiting --> Completed Initiation date: Apr 2012 --> Aug 2012

|||||||||| Enrollment open: Restless Leg Syndrome and Severe Preeclampsia (clinicaltrials.gov) - Aug 12, 2012
P=N/A, N=310, Recruiting, Sponsor: Saint Thomas Hospital, Panama
Initiation date: Apr 2012 --> Aug 2012 Not yet recruiting --> Recruiting

|||||||||| Trial completion: MEXPRE-Latin: Aggressive Versus Expectant Management of Severe Preeclampsia Remote From Term (clinicaltrials.gov) - Aug 12, 2012
P=N/A, N=264, Completed, Sponsor: Complejo Hospitalario Dr. Arnulfo Arias Madrid
Not yet recruiting --> Recruiting Recruiting --> Completed

|||||||||| New P2 trial: Chocolate Consumption in Healthy Pregnant Women Trial (clinicaltrials.gov) - Aug 5, 2012
P2, N=44, Completed, Sponsor: Laval University

|||||||||| Clinical: Longitudinal Measures of Leptin in Pregnant Women Who Developed Preeclampsia (clinicaltrials.gov) - Jul 23, 2012
P=N/A, N=55, Completed, Sponsor: Materno-Perinatal Hospital of the State of Mexico

|||||||||| Clinical: Screening for Preeclampsia With Various Markers in Low-risk Pregnancy Populations (clinicaltrials.gov) - Jul 23, 2012
P=N/A, N=262, Completed, Sponsor: CHA University

|||||||||| Trial completion: A Retrospective Analysis of Neevo (clinicaltrials.gov) - Jul 22, 2012
P=N/A, N=100, Completed, Sponsor: Pamlab, Inc.
Recruiting --> Completed Active, not recruiting --> Completed

|||||||||| Trial completion: Assessment of Physical Exercise Using Stationary Bicycle for Pregnant Women With Risk for Preeclampsia Development (clinicaltrials.gov) - Jul 10, 2012
P1, N=116, Completed, Sponsor: University of Campinas, Brazil
Active, not recruiting --> Completed Recruiting --> Completed

|||||||||| Enrollment change: Detecting Early Onset Pre-eclampsia and Use of Placental Growth Factor (PlGF) for Marker of Trisomy 21 (clinicaltrials.gov) - Jun 18, 2012
P=N/A, N=2000, Recruiting, Sponsor: OVO R & D
Recruiting --> Completed N=5000 --> 2000

|||||||||| Clinical: A Modernized Approach to Prenatal Care in Low Risk Women (clinicaltrials.gov) - May 24, 2012
P=N/A, N=80, Not yet recruiting, Sponsor: Massachusetts General Hospital

|||||||||| Trial completion: AngioPred: Prediction of the Risk of Placental Vascular Pathology and Venous Thromboembolic Disease (clinicaltrials.gov) - May 15, 2012
P=N/A, N=200, Completed, Sponsor: Centre Hospitalier Universitaire de Saint Etienne
N=5000 --> 2000 Recruiting --> Completed

||||||||||  irbesartan / Generic mfg.
Trial initiation date:  Preeclampsia: A Marker for Future Cardiovascular Risk in Women (clinicaltrials.gov) -  May 2, 2012
P=N/A, N=150, Recruiting,  Sponsor: Brigham and Women's Hospital
Recruiting --> Completed Initiation date: Feb 2012 --> May 2012

||||||||||  irbesartan / Generic mfg.
Enrollment open:  Preeclampsia: A Marker for Future Cardiovascular Risk in Women (clinicaltrials.gov) -  May 2, 2012
P=N/A, N=150, Recruiting,  Sponsor: Brigham and Women's Hospital
Initiation date: Feb 2012 --> May 2012 Not yet recruiting --> Recruiting

|||||||||| Enrollment open: Detecting Early Onset Pre-eclampsia and Use of Placental Growth Factor (PlGF) for Marker of Trisomy 21 (clinicaltrials.gov) - Apr 22, 2012
P=N/A, N=2000, Recruiting, Sponsor: OVO R & D
Not yet recruiting --> Recruiting Not yet recruiting --> Recruiting

|||||||||| Trial initiation date: Comparison of Random Spot Urine Protein:Creatinine Ratio to 24-Hour Timed Urine Protein Collection in the Evaluation of Preeclampsia (clinicaltrials.gov) - Apr 18, 2012
P=N/A, N=12000, Recruiting, Sponsor: Mike O'Callaghan Federal Hospital
Not yet recruiting --> Recruiting Initiation date: Jan 2012 --> May 2012

|||||||||| Trial completion: Effectiveness Study of Short Course of Magnesium Sulfate for Severe Preeclamsia (clinicaltrials.gov) - Apr 15, 2012
P4, N=120, Completed, Sponsor: Instituto Materno Infantil Prof. Fernando Figueira
Initiation date: Jan 2012 --> May 2012 Recruiting --> Completed

|||||||||| Trial initiation date: Improving Maternal and Child Health in India: Evaluating Demand and Supply Side Strategies (IMATCHINE) (clinicaltrials.gov) - Apr 4, 2012
P=N/A, N=14990, Recruiting, Sponsor: Duke University
Recruiting --> Completed Initiation date: Nov 2011 --> Aug 2012

|||||||||| Trial completion: Racial Differences: Nitric Oxide(NO) and Endothelin-1(ET-1) in Preeclampsia (PreE) (clinicaltrials.gov) - Apr 4, 2012
P=N/A, N=52, Completed, Sponsor: University of Mississippi Medical Center
Initiation date: Nov 2011 --> Aug 2012 Active, not recruiting --> Completed

||||||||||  Reasanz (serelaxin) / Novartis
New P2 trial:  Safety and Efficacy of RLX030 in Pregnant Women With Pre- Eclampsia (clinicaltrials.gov) -  Mar 27, 2012
P2, N=60, Recruiting,  Sponsor: Novartis Pharmaceuticals

||||||||||  enoxaparin sodium / Generic mfg.
Trial initiation date:  HOPPE: Low Weight Heparin prOphylaxis for Placental-Mediated Complications of PrEgnancy (clinicaltrials.gov) -  Mar 15, 2012
P3, N=361, Recruiting,  Sponsor: Hospital Universitari Vall d'Hebron Research Institute
Active, not recruiting --> Completed Initiation date: Sep 2011 --> Mar 2012

||||||||||  enoxaparin sodium / Generic mfg.
Enrollment open:  HOPPE: Low Weight Heparin prOphylaxis for Placental-Mediated Complications of PrEgnancy (clinicaltrials.gov) -  Mar 15, 2012
P3, N=361, Recruiting,  Sponsor: Hospital Universitari Vall d'Hebron Research Institute
Initiation date: Sep 2011 --> Mar 2012 Not yet recruiting --> Recruiting

|||||||||| Enrollment change: Clinical Trial of a COX-2 Inhibitor for the Treatment of Women With Preeclampsia (clinicaltrials.gov) - Mar 11, 2012
P2, N=0, Withdrawn, Sponsor: Virginia Commonwealth University
Not yet recruiting --> Recruiting N=32 --> 0

|||||||||| Trial completion: Evaluation of the Effectiveness of Vitamin D Supplementation to Pregnant Women and Their Infants in Pakistan. (clinicaltrials.gov) - Mar 6, 2012
P=N/A, N=460, Completed, Sponsor: Aga Khan University
N=32 --> 0 Recruiting --> Completed