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2 Companies |
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5 Products |
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5 Products |
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4 Mechanisms of Action |
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0 Trials |
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56 News |
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- | Phase classification: Safety and Effectiveness Study With a New PDA Occluder for Closure of Patent Ductus Arteriosus (clinicaltrials.gov) - Feb 15, 2024
P=N/A, N=50, Completed, Sponsor: Occlutech International AB
Phase classification: P1 --> P=N/A
- | NN1213 / Novo Nordisk
Trial completion, Trial completion date, Trial primary completion date: Early Treatment Versus Delayed Conservative Treatment of the Patent Ductus Arteriosus (clinicaltrials.gov) - May 4, 2018
P2, N=202, Completed, Sponsor: University of California, San Francisco
Phase classification: P1 --> P=N/A Recruiting --> Completed | Trial completion date: Dec 2018 --> Jun 2017 | Trial primary completion date: Dec 2017 --> Jun 2017
- ||| Trial completion: ADO II: AMPLATZER Duct Occluder II Clinical Study (clinicaltrials.gov) - Aug 23, 2017
P=N/A, N=192, Completed, Sponsor: St. Jude Medical
Recruiting --> Completed | Trial completion date: Dec 2018 --> Jun 2017 | Trial primary completion date: Dec 2017 --> Jun 2017 Active, not recruiting --> Completed
- | Trial completion: ELAPPS: Laser Acupuncture and Pain Management in Preterm Infants Undergoing Patent Ductus Arteriosus Ligation (clinicaltrials.gov) - Jul 25, 2017
P=N/A, N=40, Completed, Sponsor: Assistance Publique - H
Active, not recruiting --> Completed Recruiting --> Completed
- Trial primary completion date: ELAPPS: Laser Acupuncture and Pain Management in Preterm Infants Undergoing Patent Ductus Arteriosus Ligation (clinicaltrials.gov) - Oct 11, 2016
P=N/A, N=40, Recruiting, Sponsor: Assistance Publique - H
Recruiting --> Completed Trial primary completion date: Aug 2016 --> May 2017
- indomethacin / Generic mfg.
Enrollment change, Trial termination, Trial primary completion date: An Escalating Dose Indomethacin for the Treatment of Persistent Patent Ductus Arteriosus (PDA) In Preterm Infants (clinicaltrials.gov) - Aug 19, 2016
P2/3, N=9, Terminated, Sponsor: University of Calgary
Trial primary completion date: Aug 2016 --> May 2017 N=30 --> 9 | Recruiting --> Terminated | Trial primary completion date: Dec 2010 --> Jan 2013; Study medication was no longer available for study
- Trial primary completion date: ELAPPS: Laser Acupuncture and Pain Management in Preterm Infants Undergoing Patent Ductus Arteriosus Ligation (clinicaltrials.gov) - Aug 15, 2016
P=N/A, N=40, Recruiting, Sponsor: Assistance Publique - H
N=30 --> 9 | Recruiting --> Terminated | Trial primary completion date: Dec 2010 --> Jan 2013; Study medication was no longer available for study Trial primary completion date: May 2016 --> Aug 2016
- Trial completion: The Impact of Platelet Functions on Spontaneous Ductal Closure in Preterm Infants (clinicaltrials.gov) - Apr 26, 2016
P=N/A, N=80, Completed, Sponsor: Ankara University
Trial primary completion date: May 2016 --> Aug 2016 Recruiting --> Completed
- indomethacin / Generic mfg., ibuprofen / Generic mfg.
Trial completion, Trial primary completion date: Influence of Treatment for Patent Ductus Arteriosus on Cerebral Oxygenation in Preterm Infants (clinicaltrials.gov) - Apr 7, 2016
P4, N=35, Completed, Sponsor: University of Ulm
Recruiting --> Completed Recruiting --> Completed | Trial primary completion date: Apr 2013 --> Oct 2012
- Trial completion, Enrollment change, Trial primary completion date: Ascorbyl Peroxide Association With Bronchopulmonary Dysplasia (clinicaltrials.gov) - Nov 19, 2015
P=N/A, N=51, Completed, Sponsor: St. Justine's Hospital
Recruiting --> Completed | Trial primary completion date: Apr 2013 --> Oct 2012 Active, not recruiting --> Completed | N=240 --> 51 | Trial primary completion date: Dec 2014 --> Nov 2015
- indomethacin / Generic mfg.
Enrollment change: Comparing Ibuprofen And Indomethacin For The Treatment Of The Patent Ductus Arteriosus in Very Premature Babies (clinicaltrials.gov) - Sep 3, 2015
P4, N=0, Withdrawn, Sponsor: KK Women's and Children's Hospital
Active, not recruiting --> Completed | N=240 --> 51 | Trial primary completion date: Dec 2014 --> Nov 2015 N=150 --> 0
- Enrollment open: ELAPPS: Laser Acupuncture and Pain Management in Preterm Infants Undergoing Patent Ductus Arteriosus Ligation (clinicaltrials.gov) - Feb 6, 2015
P=N/A, N=40, Recruiting, Sponsor: Assistance Publique - H
N=150 --> 0 Not yet recruiting --> Recruiting
- indomethacin / Generic mfg., ibuprofen / Generic mfg.
Enrollment change, Trial withdrawal: Brain, Gut and Kidney Blood Flow During Medical Closure of PDA (clinicaltrials.gov) - Jan 26, 2015
P=N/A, N=0, Withdrawn, Sponsor: University of Louisville
Not yet recruiting --> Recruiting N=30 --> 0 | Recruiting --> Withdrawn
- ibuprofen / Generic mfg.
Enrollment change, Trial primary completion date: Early Versus Late Use of Ibuprofen for Patent Ductus Arteriosus (PDA) Closure (clinicaltrials.gov) - Dec 12, 2014
P=N/A, N=15, Terminated, Sponsor: University of Utah
N=30 --> 0 | Recruiting --> Withdrawn N=54 --> 15 | Trial primary completion date: Jul 2013 --> Nov 2011
- Trial completion, Enrollment change: Timing for the Medical Treatment of Patent Ductus Arteriosus in Preterm Infants (clinicaltrials.gov) - Dec 5, 2014
P=N/A, N=350, Completed, Sponsor: University of Utah
N=54 --> 15 | Trial primary completion date: Jul 2013 --> Nov 2011 Active, not recruiting --> Completed | N=200 --> 350
- | Trial completion: Safety and Effectiveness Study With a New PDA Occluder for Closure of Patent Ductus Arteriosus (clinicaltrials.gov) - Oct 17, 2014
P1, N=50, Completed, Sponsor: Occlutech International AB
Active, not recruiting --> Completed | N=200 --> 350 Active, not recruiting --> Completed
- Enrollment closed, Trial primary completion date: Ascorbyl Peroxide Association With Bronchopulmonary Dysplasia (clinicaltrials.gov) - Jul 14, 2014
P=N/A, N=240, Active, not recruiting, Sponsor: St. Justine's Hospital
Active, not recruiting --> Completed Recruiting --> Active, not recruiting | Trial primary completion date: Jun 2014 --> Dec 2014
- Trial primary completion date: Packed Red Blood Cell Transfusion and Intestinal Blood Flow in Preterm Neonates (clinicaltrials.gov) - Jun 22, 2014
P=N/A, N=25, Completed, Sponsor: St. Louis University
Recruiting --> Active, not recruiting | Trial primary completion date: Jun 2014 --> Dec 2014 Trial primary completion date: Dec 2014 --> Aug 2013
- Enrollment change: Packed Red Blood Cell Transfusion and Intestinal Blood Flow in Preterm Neonates (clinicaltrials.gov) - Jun 22, 2014
P=N/A, N=25, Completed, Sponsor: St. Louis University
Trial primary completion date: Dec 2014 --> Aug 2013 N=40 --> 25
- Trial completion, Enrollment change, Trial primary completion date: Packed Red Blood Cell Transfusion and Intestinal Blood Flow in Preterm Neonates (clinicaltrials.gov) - Jun 22, 2014
P=N/A, N=25, Completed, Sponsor: St. Louis University
N=40 --> 25 Active, not recruiting --> Completed | N=40 --> 25 | Trial primary completion date: Dec 2014 --> Aug 2013
- Enrollment closed: Packed Red Blood Cell Transfusion and Intestinal Blood Flow in Preterm Neonates (clinicaltrials.gov) - May 6, 2014
P=N/A, N=40, Active, not recruiting, Sponsor: St. Louis University
Active, not recruiting --> Completed | N=40 --> 25 | Trial primary completion date: Dec 2014 --> Aug 2013 Recruiting --> Active, not recruiting
- ibuprofen lysine / Generic mfg.
Trial termination: OIDS: Safety/Efficacy Study of Optimizing Ibuprofen Dosing to Achieve Higher PDA Closure Rates (clinicaltrials.gov) - Jan 24, 2014
P4, N=10, Terminated, Sponsor: OSF Healthcare System
Recruiting --> Active, not recruiting Not yet recruiting --> Terminated; FDA drug recall on July 30, 2010
- ibuprofen lysine / Generic mfg.
Enrollment change: OIDS: Safety/Efficacy Study of Optimizing Ibuprofen Dosing to Achieve Higher PDA Closure Rates (clinicaltrials.gov) - Jan 24, 2014
P4, N=10, Terminated, Sponsor: OSF Healthcare System
Not yet recruiting --> Terminated; FDA drug recall on July 30, 2010 N=138 --> 10
- Trial completion: Patent Ductus Arteriosus (PDA) Screening Trial (clinicaltrials.gov) - Dec 30, 2013
P=N/A, N=88, Completed, Sponsor: University of Pennsylvania
N=138 --> 10 Active, not recruiting --> Completed
- Enrollment open: The Impact of Platelet Functions on Spontaneous Ductal Closure in Preterm Infants (clinicaltrials.gov) - Dec 18, 2013
P=N/A, N=80, Recruiting, Sponsor: Ankara University
Active, not recruiting --> Completed Not yet recruiting --> Recruiting
- Enrollment open: Early Treatment Versus Delayed Conservative Treatment of the Patent Ductus Arteriosus (clinicaltrials.gov) - Dec 8, 2013
P2, N=200, Recruiting, Sponsor: University of California, San Francisco
Not yet recruiting --> Recruiting Not yet recruiting --> Recruiting
- Enrollment open: Ascorbyl Peroxide Association With Bronchopulmonary Dysplasia (clinicaltrials.gov) - Nov 11, 2013
P=N/A, N=240, Recruiting, Sponsor: St. Justine's Hospital
Not yet recruiting --> Recruiting Not yet recruiting --> Recruiting
- | New P2 trial: Early Treatment Versus Delayed Conservative Treatment of the Patent Ductus Arteriosus (clinicaltrials.gov) - Oct 7, 2013
P2, N=200, Recruiting, Sponsor: University of California, San Francisco
- Trial completion: Long Term Results of 450 Percutaneous Closures of PDA in a Single Center (clinicaltrials.gov) - Aug 20, 2013
P=N/A, N=450, Completed, Sponsor: Rambam Health Care Campus
Not yet recruiting --> Recruiting Not yet recruiting --> Completed
- Trial completion: Do Elevated BNP Levels Predict Hemodynamically Significant PDAs (clinicaltrials.gov) - Jul 1, 2013
P=N/A, N=109, Completed, Sponsor: Albany Medical College
Not yet recruiting --> Completed Recruiting --> Completed
- Enrollment closed: Safety and Effectiveness Study With a New PDA Occluder for Closure of Patent Ductus Arteriosus (clinicaltrials.gov) - May 29, 2013
P1, N=50, Active, not recruiting, Sponsor: Occlutech International AB
Recruiting --> Completed Recruiting --> Active, not recruiting
- Trial completion: Pocket Echocardiography System (PES) for Detection of PDA in Neonates (clinicaltrials.gov) - May 16, 2013
P=N/A, N=50, Completed, Sponsor: University of Florida
Recruiting --> Active, not recruiting Recruiting --> Completed
- Enrollment closed: Timing for the Medical Treatment of Patent Ductus Arteriosus in Preterm Infants (clinicaltrials.gov) - Feb 7, 2013
P=N/A, N=200, Active, not recruiting, Sponsor: University of Utah
Recruiting --> Completed Not yet recruiting --> Active, not recruiting
- Enrollment change: Impact of Maternal-infant Therapeutics on Safety, Mortality, and Disability (clinicaltrials.gov) - Jan 14, 2013
P=N/A, N=0, Withdrawn, Sponsor: Duke University
Not yet recruiting --> Active, not recruiting N=10000 --> 0
- ibuprofen / Generic mfg.
Trial completion: Oral Paracetamol Versus Oral Ibuprofen in Management of Patent Ductus Arteriosus in Preterm Infants: A Randomised Controlled Trial (clinicaltrials.gov) - Dec 23, 2012
P4, N=80, Completed, Sponsor: Zekai Tahir Burak Maternity and Teaching Hospital
N=10000 --> 0 Recruiting --> Completed
- indomethacin / Generic mfg., ibuprofen / Generic mfg.
Enrollment change: Feeding During Ibuprofen or Indomethacin Treatment of Preterm Infants (clinicaltrials.gov) - Nov 7, 2012
P=N/A, N=177, Completed, Sponsor: University of California, San Francisco
Recruiting --> Completed N=400 --> 177
- indomethacin / Generic mfg., ibuprofen / Generic mfg.
Trial completion: Feeding During Ibuprofen or Indomethacin Treatment of Preterm Infants (clinicaltrials.gov) - Nov 7, 2012
P=N/A, N=177, Completed, Sponsor: University of California, San Francisco
N=400 --> 177 Recruiting --> Completed
- indomethacin / Generic mfg., ibuprofen / Generic mfg.
Trial withdrawal: Second Course of Therapy for Resistant Patent Ductus Arteriosus (PDA) (clinicaltrials.gov) - Jun 5, 2012
P2, N=0, Withdrawn, Sponsor: Shaare Zedek Medical Center
Recruiting --> Completed Not yet recruiting --> Withdrawn
- indomethacin / Generic mfg., ibuprofen / Generic mfg.
Enrollment change: Second Course of Therapy for Resistant Patent Ductus Arteriosus (PDA) (clinicaltrials.gov) - Jun 5, 2012
P2, N=0, Withdrawn, Sponsor: Shaare Zedek Medical Center
Not yet recruiting --> Withdrawn N=68 --> 0
- | Enrollment change: Safety and Effectiveness of the Device "Nit-Occlud (clinicaltrials.gov) - May 21, 2012
P2, N=29, Completed, Sponsor: pfm S.R.L.
N=68 --> 0 N=50 --> 29
- | Trial completion: Safety and Effectiveness of the Device "Nit-Occlud (clinicaltrials.gov) - May 21, 2012
P2, N=29, Completed, Sponsor: pfm S.R.L.
N=50 --> 29 Active, not recruiting --> Completed
- New P3 trial: Echocardiographically Guided Versus Standard Ibuprofen Treatment for Patent Ductus Arteriosus (clinicaltrials.gov) - May 6, 2012
P3, N=49, Completed, Sponsor: Fundacion para la Investigacion Biomedica del Hospital Universitario la Paz
- dexmedetomidine / Generic mfg.
Clinical: The Pharmacology and Hemodynamics of Dexmedetomidine in Children With Congenital Heart Disease (clinicaltrials.gov) - Apr 30, 2012
P3, N=41, Completed, Sponsor: Children's Research Institute
Active, not recruiting --> Completed N=108 --> 41
- dexmedetomidine / Generic mfg.
Clinical: The Pharmacology and Hemodynamics of Dexmedetomidine in Children With Congenital Heart Disease (clinicaltrials.gov) - Apr 30, 2012
P3, N=41, Completed, Sponsor: Children's Research Institute
N=108 --> 41 Recruiting --> Completed
- | ibuprofen / Generic mfg.
New P4 trial: Oral Paracetamol Versus Oral Ibuprofen in Management of Patent Ductus Arteriosus in Preterm Infants: A Randomised Controlled Trial (clinicaltrials.gov) - Feb 16, 2012
P4, N=80, Completed, Sponsor: Zekai Tahir Burak Maternity and Teaching Hospital
- ibuprofen / Generic mfg.
Trial termination: Early Versus Late Use of Ibuprofen for Patent Ductus Arteriosus (PDA) Closure (clinicaltrials.gov) - Nov 22, 2011
P=N/A, N=54, Terminated, Sponsor: University of Utah
Recruiting --> Completed Active, not recruiting --> Terminated; Study drug not available
- | New P1 trial: Safety and Effectiveness Study With a New PDA Occluder for Closure of Patent Ductus Arteriosus (clinicaltrials.gov) - Nov 22, 2011
P1, N=50, Active, not recruiting, Sponsor: Occlutech International AB
- Curosurf (poractant alfa) / Chiesi
Trial termination: Curosurf and Survanta Treatment(CAST)of RDS in Very Premature Infants (clinicaltrials.gov) - Sep 18, 2011
P4, N=52, Terminated, Sponsor: Alan Fujii
Active, not recruiting --> Terminated; Study drug not available Recruiting --> Terminated; Slow recruitment,changes in protocols, larger than anticipated differences
- Curosurf (poractant alfa) / Chiesi
Enrollment change: Curosurf and Survanta Treatment(CAST)of RDS in Very Premature Infants (clinicaltrials.gov) - Sep 18, 2011
P4, N=52, Terminated, Sponsor: Alan Fujii
Recruiting --> Terminated; Slow recruitment,changes in protocols, larger than anticipated differences N=70 --> 52
- indomethacin / Generic mfg., ibuprofen / Generic mfg.
New P4 trial: Influence of Treatment for Patent Ductus Arteriosus on Cerebral Oxygenation in Preterm Infants (clinicaltrials.gov) - Aug 31, 2011
P4, N=30, Recruiting, Sponsor: University of Ulm