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7 Companies |
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4 Products |
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4 Products |
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7 Mechanisms of Action |
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1 Trial |
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141 News |
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- | amphotericin b liposome / Generic mfg.
Trial completion, Enrollment change, Combination therapy, Monotherapy: Efficacy Trial of Ambisome Given Alone and Ambisome Given in Combination With Miltefosine for the Treatment of VL HIV Positive Ethiopian Patients. (clinicaltrials.gov) - Apr 20, 2019
P3, N=59, Completed, Sponsor: Drugs for Neglected Diseases
Active, not recruiting --> Completed | N=132 --> 59
- | Trial completion, Enrollment change: Comparison of Standard and Alternative Antimonial Dosage in Patients With American Cutaneous Leishmaniasis (clinicaltrials.gov) - Jun 2, 2018
P3, N=72, Completed, Sponsor: Oswaldo Cruz Foundation
Active, not recruiting --> Completed | N=132 --> 59 Active, not recruiting --> Completed | N=264 --> 72
- | Trial completion, Trial primary completion date: Immune Responses After Human Subject Challenge With Sand Fly Bites (clinicaltrials.gov) - Feb 19, 2018
P=N/A, N=68, Completed, Sponsor: Uniformed Services University of the Health Sciences
Active, not recruiting --> Completed | N=264 --> 72 Active, not recruiting --> Completed | Trial primary completion date: Jul 2014 --> Apr 2016
- | pentoxifylline / Generic mfg.
Trial completion, Trial initiation date, Trial primary completion date: Antimony Plus Pentoxifylline in Cutaneous Leishmaniasis (clinicaltrials.gov) - Jan 26, 2017
P2/3, N=164, Completed, Sponsor: Paulo Roberto Lima Machado
Active, not recruiting --> Completed | Trial primary completion date: Jul 2014 --> Apr 2016 Active, not recruiting --> Completed | Initiation date: Jan 2011 --> Mar 2012 | Trial primary completion date: Jan 2014 --> Jan 2015
- gentamicin sulfate / Generic mfg.
Trial completion, Enrollment change, Trial initiation date, Trial primary completion date: PAGELEC: WR 279,396 for the Treatment of Cutaneous Leishmaniasis (clinicaltrials.gov) - Jan 26, 2017
P2, N=18, Completed, Sponsor: Assistance Publique - H
Active, not recruiting --> Completed | Initiation date: Jan 2011 --> Mar 2012 | Trial primary completion date: Jan 2014 --> Jan 2015 Active, not recruiting --> Completed | N=30 --> 18 | Initiation date: Jun 2014 --> Sep 2013 | Trial primary completion date: Sep 2017 --> Dec 2015
- Trial completion: Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases In Patients With Persistent Fever in Cambodia, Nepal, Democratic Republic of the Congo and Sudan (NIDIAG-Fever) (clinicaltrials.gov) - Oct 27, 2016
P=N/A, N=1927, Completed, Sponsor: University Hospital, Geneva
Active, not recruiting --> Completed | N=30 --> 18 | Initiation date: Jun 2014 --> Sep 2013 | Trial primary completion date: Sep 2017 --> Dec 2015 Active, not recruiting --> Completed
- | pentoxifylline / Generic mfg.
Trial completion, Enrollment change, IO biomarker, Immunomodulating: Add-on Study of Pentoxifylline in Cutaneous Leishmaniasis (clinicaltrials.gov) - Aug 23, 2016
P2/3, N=75, Completed, Sponsor: Centro Internacional de Entrenamiento e Investigaciones M
Active, not recruiting --> Completed Recruiting --> Completed | N=100 --> 75
- Trial completion, Trial primary completion date: Pharmacokinetics of Miltefosine in Children and Adults (clinicaltrials.gov) - Aug 22, 2016
P4, N=60, Completed, Sponsor: Centro Internacional de Entrenamiento e Investigaciones M
Recruiting --> Completed | N=100 --> 75 Recruiting --> Completed | Trial primary completion date: Dec 2014 --> May 2014
- | gentamicin sulfate / Generic mfg.
Trial completion: Phase 3 Study of Walter Reed (WR) 279,396 and Paromomycin Alone for the Treatment of Cutaneous Leishmaniasis in Panama (clinicaltrials.gov) - Aug 10, 2016
P3, N=400, Completed, Sponsor: U.S. Army Medical Research and Materiel Command
Recruiting --> Completed | Trial primary completion date: Dec 2014 --> May 2014 Active, not recruiting --> Completed
- Trial completion, Trial primary completion date: Topical 3% Amphotericin B Cream for the Treatment of Cutaneous Leishmaniasis in Colombia (clinicaltrials.gov) - Jul 26, 2016
P1/2, N=80, Completed, Sponsor: Drugs for Neglected Diseases
Active, not recruiting --> Completed Active, not recruiting --> Completed | Trial primary completion date: Nov 2015 --> May 2016
- | gentamicin sulfate / Generic mfg.
Enrollment closed: Phase 3 Study of Walter Reed (WR) 279,396 and Paromomycin Alone for the Treatment of Cutaneous Leishmaniasis in Panama (clinicaltrials.gov) - Apr 21, 2016
P3, N=400, Active, not recruiting, Sponsor: U.S. Army Medical Research and Materiel Command
Active, not recruiting --> Completed | Trial primary completion date: Nov 2015 --> May 2016 Recruiting --> Active, not recruiting
- Trial primary completion date: Comparison of Standard and Alternative Antimonial Dosage in Patients With American Cutaneous Leishmaniasis (clinicaltrials.gov) - Apr 19, 2016
P3, N=264, Active, not recruiting, Sponsor: Oswaldo Cruz Foundation
Recruiting --> Active, not recruiting Trial primary completion date: Dec 2015 --> Apr 2016
- amphotericin b liposome / Generic mfg.
Trial primary completion date, Combination therapy, Monotherapy: Efficacy Trial of Ambisome Given Alone and Ambisome Given in Combination With Miltefosine for the Treatment of VL HIV Positive Ethiopian Patients. (clinicaltrials.gov) - Mar 21, 2016
P3, N=132, Active, not recruiting, Sponsor: Drugs for Neglected Diseases
Trial primary completion date: Dec 2015 --> Apr 2016 Trial primary completion date: Jan 2016 --> Aug 2016
- Trial completion: Phase 1 LEISH-F3 + SLA-SE Vaccine Trial in Healthy Adult Volunteers (clinicaltrials.gov) - Feb 23, 2016
P1, N=39, Completed, Sponsor: IDRI
Trial primary completion date: Jan 2016 --> Aug 2016 Active, not recruiting --> Completed
- Enrollment closed, Trial primary completion date: Topical 3% Amphotericin B Cream for the Treatment of Cutaneous Leishmaniasis in Colombia (clinicaltrials.gov) - Feb 18, 2016
P1/2, N=80, Active, not recruiting, Sponsor: Drugs for Neglected Diseases
Active, not recruiting --> Completed Recruiting --> Active, not recruiting | Trial primary completion date: Feb 2015 --> Nov 2015
- | Trial completion: Prophylaxis of Visceral Leishmaniasis Relapses in HIV Co-infected Patients With Pentamidine: a Cohort Study (clinicaltrials.gov) - Feb 5, 2016
P3, N=72, Completed, Sponsor: Institute of Tropical Medicine, Belgium
Recruiting --> Active, not recruiting | Trial primary completion date: Feb 2015 --> Nov 2015 Active, not recruiting --> Completed
- amphotericin b liposome / Generic mfg.
Enrollment change, Trial primary completion date: Open-Label, Sequential Step, Safety and Efficacy Study to Determine the Optimal Single Dose of Ambisome for Patients With VL (clinicaltrials.gov) - Jan 21, 2016
P2, N=124, Terminated, Sponsor: Drugs for Neglected Diseases
Active, not recruiting --> Completed N=240 --> 124 | Trial primary completion date: Jun 2011 --> Sep 2010
- | amphotericin b liposome / Generic mfg.
Trial completion, Trial primary completion date: Phase III, Study of Three Short Course Combo (Ambisome (clinicaltrials.gov) - Jan 21, 2016
P3, N=602, Completed, Sponsor: Drugs for Neglected Diseases
N=240 --> 124 | Trial primary completion date: Jun 2011 --> Sep 2010 Recruiting --> Completed | Trial primary completion date: Dec 2011 --> Mar 2014
- Trial completion: Bihar Evaluation of Social Franchising and Telemedicine (clinicaltrials.gov) - Dec 16, 2015
P=N/A, N=106380, Completed, Sponsor: Duke University
Recruiting --> Completed | Trial primary completion date: Dec 2011 --> Mar 2014 Active, not recruiting --> Completed
- Enrollment change, Trial termination, Trial primary completion date: High Dose Fluconazole in Cutaneous Leishmaniasis in Bahia and Manaus (clinicaltrials.gov) - Dec 4, 2015
P3, N=53, Terminated, Sponsor: Hospital Universit
Active, not recruiting --> Completed N=140 --> 53 | Not yet recruiting --> Terminated | Trial primary completion date: Dec 2014 --> Apr 2015; Low cure rate in the study (fluconazole) group
- gentamicin sulfate / Generic mfg.
Enrollment closed: PAGELEC: WR 279,396 for the Treatment of Cutaneous Leishmaniasis (clinicaltrials.gov) - Nov 27, 2015
P2, N=30, Active, not recruiting, Sponsor: Assistance Publique - H
N=140 --> 53 | Not yet recruiting --> Terminated | Trial primary completion date: Dec 2014 --> Apr 2015; Low cure rate in the study (fluconazole) group Recruiting --> Active, not recruiting
- Trial primary completion date: Prophylaxis of Visceral Leishmaniasis Relapses in HIV Co-infected Patients With Pentamidine: a Cohort Study (clinicaltrials.gov) - Sep 24, 2015
P3, N=72, Active, not recruiting, Sponsor: Institute of Tropical Medicine, Belgium
Recruiting --> Active, not recruiting Trial primary completion date: Aug 2015 --> Dec 2015
- Fexinidazole Winthrop (fexinidazole) / Sanofi
Enrollment change, Trial termination: Trial to Determine Efficacy of Fexinidazole in Visceral Leihmaniasis Patients in Sudan (clinicaltrials.gov) - Sep 18, 2015
P2, N=14, Terminated, Sponsor: Drugs for Neglected Diseases
Trial primary completion date: Aug 2015 --> Dec 2015 N=66 --> 14 | Recruiting --> Terminated; Lack of efficacy
- | amphotericin b liposome / Generic mfg.
Enrollment closed, Combination therapy, Monotherapy: Efficacy Trial of Ambisome Given Alone and Ambisome Given in Combination With Miltefosine for the Treatment of VL HIV Positive Ethiopian Patients. (clinicaltrials.gov) - Sep 18, 2015
P3, N=132, Active, not recruiting, Sponsor: Drugs for Neglected Diseases
N=66 --> 14 | Recruiting --> Terminated; Lack of efficacy Recruiting --> Active, not recruiting
- Trial primary completion date: Phase 1 LEISH-F3 + SLA-SE Vaccine Trial in Healthy Adult Volunteers (clinicaltrials.gov) - Aug 25, 2015
P1, N=39, Active, not recruiting, Sponsor: IDRI
Recruiting --> Active, not recruiting Trial primary completion date: Jun 2015 --> Dec 2015
- | Enrollment closed, Trial primary completion date: Comparison of Standard and Alternative Antimonial Dosage in Patients With American Cutaneous Leishmaniasis (clinicaltrials.gov) - Jun 20, 2015
P3, N=264, Active, not recruiting, Sponsor: Oswaldo Cruz Foundation
Trial primary completion date: Jun 2015 --> Dec 2015 Recruiting --> Active, not recruiting | Trial primary completion date: Jun 2013 --> Dec 2015
- || Trial primary completion date: Bihar Evaluation of Social Franchising and Telemedicine (clinicaltrials.gov) - Jun 16, 2015
P=N/A, N=106380, Active, not recruiting, Sponsor: Duke University
Recruiting --> Active, not recruiting | Trial primary completion date: Jun 2013 --> Dec 2015 Trial primary completion date: Apr 2015 --> Dec 2014
- Trial primary completion date: Immune Responses After Human Subject Challenge With Sand Fly Bites (clinicaltrials.gov) - Jun 11, 2015
P=N/A, N=68, Active, not recruiting, Sponsor: Uniformed Services University of the Health Sciences
Trial primary completion date: Apr 2015 --> Dec 2014 Trial primary completion date: Oct 2012 --> Jul 2014
- Trial completion, Phase classification, Trial initiation date, Trial primary completion date: Clinical Trial of Miltefosine to Treat Mucosal Leishmaniasis (clinicaltrials.gov) - Jun 9, 2015
P2, N=40, Completed, Sponsor: Brasilia University Hospital
Trial primary completion date: Oct 2012 --> Jul 2014 Recruiting --> Completed | Phase classification: P3 --> P2 | Initiation date: Jan 2010 --> Jul 2009 | Trial primary completion date: Jul 2011 --> Jun 2013
- Trial completion: LEISH-F3 + GLA-SE and the LEISH-F3 + MPL-SE Vaccine (clinicaltrials.gov) - Jun 6, 2015
P1, N=48, Completed, Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting --> Completed | Phase classification: P3 --> P2 | Initiation date: Jan 2010 --> Jul 2009 | Trial primary completion date: Jul 2011 --> Jun 2013 Active, not recruiting --> Completed
- gentamicin sulfate / Generic mfg.
Trial primary completion date: PAGELEC: WR 279,396 for the Treatment of Cutaneous Leishmaniasis (clinicaltrials.gov) - Apr 25, 2015
P2, N=30, Recruiting, Sponsor: Assistance Publique - H
Active, not recruiting --> Completed Trial primary completion date: Dec 2014 --> Sep 2017
- Enrollment closed: Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases In Patients With Persistent Fever in Cambodia, Nepal, Democratic Republic of the Congo and Sudan (NIDIAG-Fever) (clinicaltrials.gov) - Apr 14, 2015
P=N/A, N=1927, Active, not recruiting, Sponsor: University Hospital, Geneva
Trial primary completion date: Dec 2014 --> Sep 2017 Recruiting --> Active, not recruiting
- || Enrollment closed: Bihar Evaluation of Social Franchising and Telemedicine (clinicaltrials.gov) - Feb 27, 2015
P=N/A, N=106380, Active, not recruiting, Sponsor: Duke University
Recruiting --> Active, not recruiting Enrolling by invitation --> Active, not recruiting
- | Trial completion: Replacement of Insecticides to Control Visceral Leishmaniasis (VL) (clinicaltrials.gov) - Feb 19, 2015
P3, N=3600, Completed, Sponsor: International Centre for Diarrhoeal Disease Research, Bangladesh
Enrolling by invitation --> Active, not recruiting Recruiting --> Completed
- Trial primary completion date: Prophylaxis of Visceral Leishmaniasis Relapses in HIV Co-infected Patients With Pentamidine: a Cohort Study (clinicaltrials.gov) - Jan 22, 2015
P3, N=72, Active, not recruiting, Sponsor: Institute of Tropical Medicine, Belgium
Recruiting --> Completed Trial primary completion date: Aug 2014 --> Aug 2015
- Trial primary completion date: LEISH-F3 + GLA-SE and the LEISH-F3 + MPL-SE Vaccine (clinicaltrials.gov) - Jan 9, 2015
P1, N=48, Active, not recruiting, Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Trial primary completion date: Aug 2014 --> Aug 2015 Trial primary completion date: Sep 2014 --> Jan 2015
- | gentamicin sulfate / Generic mfg.
Enrollment change, Trial primary completion date: Phase 3 Study of Walter Reed (WR) 279,396 and Paromomycin Alone for the Treatment of Cutaneous Leishmaniasis in Panama (clinicaltrials.gov) - Dec 19, 2014
P3, N=400, Recruiting, Sponsor: U.S. Army Medical Research and Materiel Command
Trial primary completion date: Sep 2014 --> Jan 2015 N=300 --> 400 | Trial primary completion date: Jun 2015 --> Dec 2015
- gentamicin sulfate / Generic mfg.
Enrollment change, Trial termination, Trial primary completion date: WR 279,396 Open Label Treatment Protocol in Tunisia (clinicaltrials.gov) - Dec 19, 2014
P2, N=50, Terminated, Sponsor: U.S. Army Medical Research and Materiel Command
N=300 --> 400 | Trial primary completion date: Jun 2015 --> Dec 2015 N=120 --> 50 | Suspended --> Terminated | Trial primary completion date: Aug 2013 --> Jun 2012; This study was closed prematurely due study team travel restrictions.
- Enrollment closed: Phase 1 LEISH-F3 + SLA-SE Vaccine Trial in Healthy Adult Volunteers (clinicaltrials.gov) - Nov 24, 2014
P1, N=39, Active, not recruiting, Sponsor: Infectious Disease Research Institute
N=120 --> 50 | Suspended --> Terminated | Trial primary completion date: Aug 2013 --> Jun 2012; This study was closed prematurely due study team travel restrictions. Recruiting --> Active, not recruiting
- Trial completion, Trial primary completion date, IO biomarker: A Study to Explore Association of Treatment Regimens for Visceral Leishmaniasis, Host Immunological, Genetical and Nutrition Factors With Post-kala-azar Dermal Leishmaniasis (PKDL) (clinicaltrials.gov) - Nov 5, 2014
P4, N=36, Completed, Sponsor: International Centre for Diarrhoeal Disease Research, Bangladesh
Recruiting --> Active, not recruiting Active, not recruiting --> Completed | Trial primary completion date: Dec 2013 --> Sep 2014
- azithromycin / Generic mfg.
Enrollment change, Trial termination: PCL01: Safety and Efficacy of Azithromycin to Treat Cutaneous Leishmaniasis (clinicaltrials.gov) - Oct 17, 2014
P2/3, N=48, Terminated, Sponsor: Ana Rabello
Active, not recruiting --> Completed | Trial primary completion date: Dec 2013 --> Sep 2014 N=620 --> 48 | Recruiting --> Terminated; Efficacy issues on test arm
- | amphotericin b liposome / Generic mfg.
Enrollment open, Combination therapy, Monotherapy: Efficacy Trial of Ambisome Given Alone and Ambisome Given in Combination With Miltefosine for the Treatment of VL HIV Positive Ethiopian Patients. (clinicaltrials.gov) - Sep 29, 2014
P3, N=132, Recruiting, Sponsor: Drugs for Neglected Diseases
N=620 --> 48 | Recruiting --> Terminated; Efficacy issues on test arm Not yet recruiting --> Recruiting
- |||| Lenocta (sodium stibogluconate) / VioQuest
Trial completion: Clinical Trial to Assess the Safety and Efficacy of Sodium Stibogluconate (SSG) and AmBisome (clinicaltrials.gov) - Sep 29, 2014
P2, N=183, Completed, Sponsor: Drugs for Neglected Diseases
Not yet recruiting --> Recruiting Recruiting --> Completed
- ||| Trial completion: Evaluation of CL Detect (clinicaltrials.gov) - Sep 8, 2014
P=N/A, N=150, Completed, Sponsor: U.S. Army Medical Research and Materiel Command
Recruiting --> Completed Active, not recruiting --> Completed
- ||| Trial completion, Trial primary completion date: CL Detect (clinicaltrials.gov) - Sep 8, 2014
P=N/A, N=150, Completed, Sponsor: U.S. Army Medical Research and Materiel Command
Active, not recruiting --> Completed Recruiting --> Completed | Trial primary completion date: Mar 2013 --> Aug 2013
- gentamicin sulfate / Generic mfg.
Trial primary completion date: Safety, Efficacy and Pharmacokinetics (PK) Study of WR 279,396 Versus Paromomycin for Treatment of Cutaneous Leishmaniasis (Peru-PK) (clinicaltrials.gov) - Aug 22, 2014
P2, N=30, Completed, Sponsor: U.S. Army Medical Research and Materiel Command
Recruiting --> Completed | Trial primary completion date: Mar 2013 --> Aug 2013 Trial primary completion date: Jul 2011 --> Mar 2011
- Trial primary completion date: Replacement of Insecticides to Control Visceral Leishmaniasis (VL) (clinicaltrials.gov) - Jul 12, 2014
P3, N=3600, Recruiting, Sponsor: International Centre for Diarrhoeal Disease Research, Bangladesh
Trial primary completion date: Jul 2011 --> Mar 2011 Trial primary completion date: Dec 2013 --> Dec 2014
- | amphotericin b liposome / Generic mfg.
Trial initiation date, Trial primary completion date, Combination therapy, Monotherapy: Efficacy Trial of Ambisome Given Alone and Ambisome Given in Combination With Miltefosine for the Treatment of VL HIV Positive Ethiopian Patients. (clinicaltrials.gov) - Jul 12, 2014
P3, N=132, Not yet recruiting, Sponsor: Drugs for Neglected Diseases
Trial primary completion date: Dec 2013 --> Dec 2014 Initiation date: Dec 2013 --> Jul 2014 | Trial primary completion date: Jun 2015 --> Jan 2016
- gentamicin sulfate / Generic mfg.
Trial initiation date: PAGELEC: WR 279,396 for the Treatment of Cutaneous Leishmaniasis (clinicaltrials.gov) - Jun 17, 2014
P2, N=30, Recruiting, Sponsor: Assistance Publique - H
Initiation date: Dec 2013 --> Jul 2014 | Trial primary completion date: Jun 2015 --> Jan 2016 Initiation date: Sep 2013 --> Jun 2014
- Trial primary completion date: Topical 3% Amphotericin B Cream for the Treatment of Cutaneous Leishmaniasis in Colombia (clinicaltrials.gov) - Jun 13, 2014
P1/2, N=80, Recruiting, Sponsor: Drugs for Neglected Diseases
Initiation date: Sep 2013 --> Jun 2014 Trial primary completion date: May 2014 --> Feb 2015