Keratoconus
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 5 Companies   5 Products   5 Products   8 Mechanisms of Action   1 Trial   89 News 


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  • ||||||||||  NN1213 / Novo Nordisk
    Phase classification, Trial completion date, Trial termination, Trial primary completion date:  CXL-04 A Study of Collagen Crosslinking With Ultraviolet-A in Asymmetric Corneas (clinicaltrials.gov) -  Oct 12, 2018   
    P2,  N=1324, Terminated, 
    N=1996 --> 3493 Phase classification: P4 --> P2 | Trial completion date: Jun 2018 --> Feb 2017 | Recruiting --> Terminated | Trial primary completion date: Jan 2018 --> Feb 2017
  • ||||||||||  Enrollment change:  Collagen Crosslinking With Ultraviolet-A in Asymmetric Corneas (2) (clinicaltrials.gov) -  Oct 11, 2018   
    P=N/A,  N=2619, Terminated, 
    Phase classification: P4 --> P2 | Trial completion date: Jun 2018 --> Feb 2017 | Recruiting --> Terminated | Trial primary completion date: Jan 2018 --> Feb 2017 N=538 --> 2619
  • ||||||||||  Trial completion date, Trial termination, Trial primary completion date:  Collagen Crosslinking With Ultraviolet-A in Asymmetric Corneas (2) (clinicaltrials.gov) -  Sep 26, 2018   
    P=N/A,  N=538, Terminated, 
    N=2500 --> 1189 Trial completion date: Dec 2018 --> Apr 2017 | Recruiting --> Terminated | Trial primary completion date: Dec 2018 --> Apr 2017; Terminated to initiate FDA IND-cleared study protocol
  • ||||||||||  Flarex (fluorometholone acetate ophthalmic suspension) / Novartis
    Enrollment change, Trial completion date, Trial termination, Trial primary completion date:  Cross-linking of Corneal Collagen (CXL) With Ultraviolet-A in Asymmetric Corneas (clinicaltrials.gov) -  Sep 26, 2018   
    P=N/A,  N=1996, Terminated, 
    Trial completion date: Dec 2018 --> Apr 2017 | Recruiting --> Terminated | Trial primary completion date: Dec 2018 --> Apr 2017; Terminated to initiate FDA IND-cleared study protocol N=500 --> 1996 | Trial completion date: Dec 2018 --> Feb 2017 | Recruiting --> Terminated | Trial primary completion date: Dec 2018 --> Feb 2017; Terminated to initiate FDA IND-cleared study protocol
  • ||||||||||  Flarex (fluorometholone acetate ophthalmic suspension) / Novartis
    Enrollment change, Trial completion date, Trial termination, Trial primary completion date:  Collagen Crosslinking With Ultraviolet-A in Asymmetric Corneas (clinicaltrials.gov) -  Sep 26, 2018   
    P=N/A,  N=2500, Terminated, 
    N=500 --> 1996 | Trial completion date: Dec 2018 --> Feb 2017 | Recruiting --> Terminated | Trial primary completion date: Dec 2018 --> Feb 2017; Terminated to initiate FDA IND-cleared study protocol N=1500 --> 2500 | Trial completion date: Dec 2018 --> Feb 2017 | Recruiting --> Terminated | Trial primary completion date: Dec 2018 --> Feb 2017; Terminated to initiate FDA IND-cleared study protocol
  • ||||||||||  Trial completion:  Corneal Crosslinking in Patients With Keratoconus and Post-Refractive Ectasia (clinicaltrials.gov) -  Jun 3, 2018   
    P2,  N=510, Completed, 
    N=1500 --> 2500 | Trial completion date: Dec 2018 --> Feb 2017 | Recruiting --> Terminated | Trial primary completion date: Dec 2018 --> Feb 2017; Terminated to initiate FDA IND-cleared study protocol Active, not recruiting --> Completed
  • ||||||||||  Trial completion, Enrollment change:  CEI Van Outreach Screening Study (clinicaltrials.gov) -  Apr 12, 2018   
    P=N/A,  N=118, Completed, 
    Active, not recruiting --> Completed Active, not recruiting --> Completed | N=200 --> 118
  • ||||||||||  Enrollment change, Trial completion date, Trial termination, Trial primary completion date:  OCT-guided LALAK for KCN (clinicaltrials.gov) -  Apr 6, 2018   
    P=N/A,  N=5, Terminated, 
    Active, not recruiting --> Completed | N=200 --> 118 N=94 --> 5 | Trial completion date: Aug 2016 --> Aug 2017 | Recruiting --> Terminated | Trial primary completion date: Aug 2016 --> Aug 2017; Modifying procedure
  • ||||||||||  Trial completion, Phase classification, Enrollment change, Trial completion date, Trial primary completion date:  Observational Study of Keratoconus and Post-keratoplasty Eyes (clinicaltrials.gov) -  Apr 6, 2018   
    P,  N=7, Completed, 
    N=94 --> 5 | Trial completion date: Aug 2016 --> Aug 2017 | Recruiting --> Terminated | Trial primary completion date: Aug 2016 --> Aug 2017; Modifying procedure Recruiting --> Completed | Phase classification: PN/A --> P | N=50 --> 7 | Trial completion date: Jun 2016 --> Aug 2017 | Trial primary completion date: Jun 2016 --> Aug 2017
  • ||||||||||  Enrollment change:  Corneal Crosslinking in Patients With Keratoconus and Post-Refractive Ectasia (clinicaltrials.gov) -  Sep 15, 2017   
    P2,  N=510, Active, not recruiting, 
    Recruiting --> Completed | Phase classification: PN/A --> P | N=50 --> 7 | Trial completion date: Jun 2016 --> Aug 2017 | Trial primary completion date: Jun 2016 --> Aug 2017 N=264 --> 510
  • ||||||||||  Enrollment change, Trial primary completion date, Combination therapy:  Corneal Cross Linking and Topography Guided Excimer Laser Treatment (clinicaltrials.gov) -  Apr 26, 2017   
    P3,  N=30, Terminated, 
    Trial primary completion date: May 2017 --> Nov 2017 N=40 --> 30 | Trial primary completion date: Dec 2014 --> Dec 2015
  • ||||||||||  Phase classification, Enrollment change, Trial termination, Trial primary completion date:  VOPTICA: Measurement of High Order Aberrations in Late Stages Keratoconus (clinicaltrials.gov) -  Feb 23, 2017   
    P=N/A,  N=28, Terminated, 
    Recruiting --> Active, not recruiting Phase classification: P1/2 --> P=N/A | N=500 --> 28 | Recruiting --> Terminated | Trial primary completion date: Oct 2016 --> Nov 2012; Lack of recruitment
  • ||||||||||  Flarex (fluorometholone acetate ophthalmic suspension) / Novartis
    Phase classification:  Collagen Crosslinking With Ultraviolet-A in Asymmetric Corneas (clinicaltrials.gov) -  Feb 3, 2017   
    P=N/A,  N=1500, Recruiting, 
    Phase classification: P1/2 --> P=N/A | N=500 --> 28 | Recruiting --> Terminated | Trial primary completion date: Oct 2016 --> Nov 2012; Lack of recruitment Phase classification: P4 --> P=N/A
  • ||||||||||  Enrollment closed, Trial primary completion date:  TransPRKCXL: Simultaneous TransPRK and Corneal Collagen Cross-Linking (clinicaltrials.gov) -  Mar 16, 2016   
    P=N/A,  N=50, Active, not recruiting, 
    Recruiting --> Completed Enrolling by invitation --> Active, not recruiting | Trial primary completion date: Aug 2015 --> Jul 2016
  • ||||||||||  Flarex (fluorometholone acetate ophthalmic suspension) / Novartis
    Trial primary completion date:  Collagen Crosslinking With Ultraviolet-A in Asymmetric Corneas (clinicaltrials.gov) -  Aug 19, 2015   
    P4,  N=1500, Recruiting, 
    Trial primary completion date: Dec 2014 --> Dec 2018 Trial primary completion date: Dec 2014 --> Dec 2018
  • ||||||||||  Trial primary completion date:  Microwave Treatment and Corneal Collagen Crosslinking for Keratoconus (clinicaltrials.gov) -  Aug 13, 2015   
    P3,  N=130, Recruiting, 
    Recruiting --> Completed | N=500 --> 22 | Trial primary completion date: Dec 2014 --> Jun 2014 Trial primary completion date: Aug 2015 --> Aug 2016
  • ||||||||||  Trial completion:  FLAK: Femtosecond Laser-Assisted Keratoplasty (clinicaltrials.gov) -  Jan 22, 2015   
    P=N/A,  N=24, Completed, 
    Trial primary completion date: May 2015 --> Dec 2016 Active, not recruiting --> Completed
  • ||||||||||  Trial completion, Trial primary completion date:  Transepithelial Corneal Collagen Cross-linking (CXL) in Treatment of Keratoconus (clinicaltrials.gov) -  Dec 13, 2014   
    P2,  N=20, Completed, 
    Recruiting --> Active, not recruiting | Trial primary completion date: Dec 2014 --> Jan 2016 Enrolling by invitation --> Completed | Trial primary completion date: May 2012 --> Dec 2014
  • ||||||||||  Trial termination:  Twelve Month Clinical Evaluation of KeraSoft IC Soft Contact Lenses (clinicaltrials.gov) -  Nov 25, 2014   
    P=N/A,  N=12, Terminated, 
    Enrolling by invitation --> Completed | Trial primary completion date: May 2012 --> Dec 2014 Completed --> Terminated; Study was terminated due to a business decision to cancel the entire project.
  • ||||||||||  Botox (onabotulinumtoxin A) / GSK, AbbVie, Healis Therap
    Trial completion:  Botulinum Toxin A for the Treatment of Keratoconus (clinicaltrials.gov) -  Oct 22, 2014   
    P=N/A,  N=40, Completed, 
    Not yet recruiting --> Recruiting Active, not recruiting --> Completed
  • ||||||||||  Trial primary completion date:  CEI Van Outreach Screening Study (clinicaltrials.gov) -  Sep 4, 2014   
    P=N/A,  N=200, Active, not recruiting, 
    Trial primary completion date: Aug 2013 --> Aug 2015 Trial primary completion date: Jan 2014 --> Dec 2015
  • ||||||||||  Enrollment closed, Combination therapy:  Corneal Cross Linking and Topography Guided Excimer Laser Treatment (clinicaltrials.gov) -  Dec 3, 2013   
    P3,  N=40, Active, not recruiting, 
    Trial primary completion date: Oct 2013 --> Oct 2014 Recruiting --> Active, not recruiting