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ACTRN12609000066280: Investigation of Caspofungin Eye Drops for the Treatment of Fungal Eye Infections |
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| Not yet recruiting | 4 | 30 | | | Monash, Contributing to Australian Scholarship & Sciences (CASS) Foundation | Fungal Keratitis | | | | |
ACTRN12605000273684: A comparison of topical anaesthesia with placebo for the managment of minor corneal trauma. |
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| Recruiting | 4 | 0 | | | Ken Barns, Mater Foundation | Emergency department presentations of corneal abrasion, corneal foreign bodies and UV keratitis. | | | | |
| Recruiting | 4 | 144 | | | University of Auckland, University of Auckland | Bacterial keratitis | | | | |
ChiCTR2100053592: clinical efficacy evaluation about recombinant human nerve growth factor on neurotrophic keratitis |
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| Recruiting | 4 | 20 | | Nil | Xi'an First Hospital; Xi'an First Hospital, self-raised | neurotrophic keratitis (NK) | | | | |
| Not yet recruiting | 4 | 60 | | 0.05% cyclosporine eye drops ;artificial tears | Department of Ophthalmology, the First Affiliated Hospital of Northwestern University, Xi'an No.1 Hospital; Department of Ophthalmology, the First Affiliated Hospital of Northwestern University, Bethune Dry Eye Diagnosis and Research Foundation | Herpes simplex viral keratitis, dry eye | | | | |
NCT05720715: Clinical Outcomes of Cyclosporine Eye Drops in Management of Herpetic Keratitis |
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| Completed | 4 | 30 | RoW | cyclosporine A 0.05% eye drops | Farwaniya Hospital | Outcomes of Cyclosporine Eye Drops in Herpetic Keratitis | 03/24 | 03/24 | | |
NCT06331910: Efficacy and Safety of Topical Insulin for Neurotrophic Corneal Ulcers |
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| Not yet recruiting | 4 | 14 | NA | insulin eye drops | Assiut University | Neurotrophic Keratopathy | 04/25 | 05/25 | | |
IMAGO, NCT06411145: Open-label Trial to Evaluate Efficacy and Safety of rhNGF on Corneal Thickness Via AS-OCT in Neurotrophic Keratitis |
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| Withdrawn | 4 | 17 | NA | OXERVATE® 0.002%, cenegermin-bkbj | Dompé Farmaceutici S.p.A | Neurotrophic Keratitis, Neurotrophic Keratopathy, Corneal Ulcer | 11/24 | 11/24 | | |
2016-001823-30: Efficacy, Safety and Tolerability of 0.08% PHMB eye drops in comparison with 0.02% PHMB + 0.1% Propamidine eye drops in patients with Acanthamoeba keratitis |
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| Ongoing | 3 | 130 | Europe | Polyhexamethylene biguanide hydrochloride 0.08%, Polyhexamethylene biguanide hydrochloride 0.02%, Brolene, PHMB 0.08%, PHMB 0.02%, Eye drops, solution, Brolene | SIFI SpA, SOCIETÀ INDUSTRIA FARMACEUTICA ITALIANA (SIFI) SPA, SIFI SpA, | Acanthamoeba keratitis, Corneal Infection due to Acanthamoeba, Diseases [C] - Eye Diseases [C11] | | | | |
| Completed | 3 | 135 | Europe | PHMB 0.08%, Polihexanide 0.8 mg/ml, Propamidine 0.1%, Brolene eye drops, placebo, Brolene vehicle, PHMB 0.02%, Polihexanide 0.2 mg/ml | SIFI SpA, SIFI SpA, | Acanthamoeba Keratitis | 06/21 | 03/22 | | |
NCT05689996: Ozone-based Eye Drops as Adjuvant Therapy in Microbial Keratitis |
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| Not yet recruiting | 3 | 40 | NA | Ozone-Based Agent, ozone-based eye drops | Assiut University | Keratitis | 04/23 | 05/23 | | |
| Completed | 3 | 350 | Europe, RoW | Open-label Ikervis, Masked Ikervis, Vehicle Comparator: Masked Vehicle | Santen SAS | Dry Eye Disease With Severe Keratitis | 07/23 | 07/23 | | |
| Recruiting | 3 | 60 | RoW | Difluprednate Ophthalmic, Rose Bengal, Corneal Cross Linking with rose Bengal, Moxifloxacin Ophthalmic | University of California, San Francisco, Stanford University, Aravind Eye Care System, Federal University of São Paulo | Bacterial Keratitis | 07/25 | 12/25 | | |
| Recruiting | 3 | 232 | Europe, US, RoW | Polyhexamethylene biguanide (PHMB), Polyhexanide, Topical corticosteroid, Topical placebo | Jeremy Keenan, MD, MPH, Johns Hopkins University, Oregon Health and Science University, University of Illinois at Chicago, University of Michigan, University of California, Los Angeles, University of Miami, University of Pennsylvania, Columbia University, University of Iowa, University of Florida, Aravind Eye Care System, Moorfields Eye Hospital NHS Foundation Trust, Federal University of São Paulo, National Eye Institute (NEI) | Acanthamoeba Keratitis | 07/28 | 07/28 | | |
| Active, not recruiting | 3 | 280 | US, RoW | Moxifloxacin Ophthalmic, Difluprednate Ophthalmic, Riboflavin Ophthalmic, Corneal Cross-Linking with Riboflavin Ophthalmic, Topical Placebo | Thomas M. Lietman, Aravind Eye Care System, National Eye Institute (NEI), University of Miami, Stanford University | Keratitis Bacterial | 08/24 | 11/24 | | |
| Not yet recruiting | 3 | 150 | US, RoW | Cyclosporine A, Placebo Comparator: Placebo | University of California, San Francisco, Aravind Eye Hospitals, India, Aravind Eye Care System | Fungal Keratitis, Corneal Ulcer | 01/27 | 01/27 | | |
REAGIR, NCT05110001: Rose Bengal Electromagnetic Activation With Green Light for Infection Reduction |
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| Active, not recruiting | 3 | 330 | RoW | Moxifloxacin Ophthalmic, Chlorhexidine Gluconate, Natamycin, Rose Bengal, Corneal Cross Linking with rose Bengal, Placebo | University of California, San Francisco, Aravind Eye Care System, National Eye Institute (NEI), Stanford University, Federal University of São Paulo | Acanthamoeba Keratitis, Fungal Keratitis | 01/25 | 04/25 | | |
NCT06539663: The Role of OmniLenz® in the Treatment of Small Corneal Perforations Secondary to Exposure Keratitis in ICU Patients |
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| Completed | 2/3 | 5 | RoW | OmniLenz® | Farwaniya Hospital | Corneal Perforation, Exposure Keratitis, Infectious Keratitis | 02/24 | 04/24 | | |
NCT05255107: Safety and Effectiveness of the PXL Platinum 330 System With Riboflavin Solution for Previously Untreated Corneal Ulcers |
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| Recruiting | 2/3 | 468 | US | Standard of Care Therapy + CXL + Riboflavin 0.23% L Solution, Standard of Care Therapy + Sham CXL + Artificial Tears | Peschke GmbH | Keratitis, Corneal Ulcer | 11/23 | 02/24 | | |
NCT05255016: Safety and Effectiveness of the PXL Platinum 330 System With Riboflavin Solution for Refractory Corneal Ulcers |
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| Recruiting | 2/3 | 488 | US | PXL Platinum 330 system + Riboflavin 0.25% TE Solution, Sham CXL + Artificial Tears | Peschke GmbH | Keratitis, Corneal Ulcer | 11/23 | 02/24 | | |
NCT05321251: Topical Insulin Drops for the Treatment of Neurotrophic Keratopathy. |
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| Withdrawn | 2/3 | 60 | Canada | Insulin, Tarsorrhaphy | University of Alberta | Neurotrophic Keratitis | 10/23 | 10/23 | | |
| Active, not recruiting | 2 | 49 | RoW | Chlorhexidine, Povidone-Iodine, Prednisolone Sodium Phosphate, Hydroxypropyl Methylcellulose | University of California, San Francisco, Research to Prevent Blindness | Acanthamoeba Keratitis | 12/24 | 12/24 | | |
| Completed | 2 | 108 | Europe, US | Udonitrectag, Vehicle | Recordati Rare Diseases, Syneos Health | Neurotrophic Keratitis | 04/24 | 04/24 | | |
NCT06474442: A Phase Ⅱa Study of the Safety, Tolerability and Efficacy of BD111 in Herpes Simplex Virus Type I Stromal Keratitis |
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| Not yet recruiting | 2 | 40 | RoW | BD111 Injection (investigational new drug), BD111 Lentivirus-like particles, also called HSV-1-erasing lentiviral particles (HELP), Triple-drugs therapy of HSV-1 stromal keratitis, Ganciclovir Eye gel+Valacilovir Tablets+Prednisolone Acetate Eye Drops | Shanghai BDgene Co., Ltd. | Herpes Simplex Virus Type I Stromal Keratitis | 12/25 | 12/26 | | |
NCT05705024: Efficacy of Locally Delivered Allogeneic Mesenchymal Stromal Cells |
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| Recruiting | 2 | 38 | US | Mesenchymal Stromal Cells, Control Solution | University of Illinois at Chicago, United States Department of Defense | Corneal Ulcer | 09/25 | 09/25 | | |
NCT06463678: Trial to Evaluate the Efficacy And Safety of IVIEW-1201 In the Treatment of Fungal Keratitis |
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| Not yet recruiting | 2 | 60 | NA | IVIEW-1201, Treatment Arm, NATACYN®, Active Comparator Arm | IVIEW Therapeutics Inc. | Fungal Keratitis | 12/26 | 12/26 | | |
NCT05927428: Assessment of the Initial Efficacy and Safety of BRM424 Ophthalmic Solutions in Patients With Neurotrophic Keratitis |
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| Recruiting | 2 | 12 | US | BRM424 Ophthalmic Solution - Dose1, BRM424 Ophthalmic Solution - Dose2 | BRIM Biotechnology Inc. | Neurotrophic Keratitis | 08/25 | 11/25 | | |
NCT04213885: Safety and Effectiveness of the PXL Platinum 330 System for Corneal Collagen Cross-Linking in Eyes With Corneal Thinning Position |
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| Completed | 2 | 12 | US | PXL 330 Platinum device/Riboflavin | Eye Specialists of Indiana | Keratoconus, Unstable, Ectasia Corneal, Bacterial Keratitis | 08/24 | 08/24 | | |
NCT04909450: Study to Evaluate the Safety and Efficacy of CSB-001 Ophthalmic Solution 0.1% in Neurotrophic Keratitis Subjects |
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| Completed | 1/2 | 131 | Canada, US | CSB-001 Ophthalmic Solution 0.1%, Vehicle Control | Claris Biotherapeutics, Inc. | Neurotrophic Keratitis | 05/24 | 06/24 | | |
ChiCTR-ONC-12002510: A study for safety andeffecacy of acellular corneal stroma in the treatment of corneal ulcer |
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| Completed | 1 | 120 | | acellular corneal stroma | Beijing Tongren Hospital, Capital Medical University; Beijing Tongren Hospital, Capital Medical University, Shenzhen AiNear Cornea Engineering Co., Ltd | Corneal ulcer | | | | |
NCT06474416: A Study of the Safety, Tolerability and Prelinminary Efficacy of BD111 in Herpes Simplex Virus Type I Stromal Keratitis |
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| Recruiting | 1 | 16 | RoW | BD111 Injection (Investigative New Drug), BD111 Lentivirus-like particles, HSV-1-erasing lentiviral particles, HELP, Triple-drugs therapy of HSV-1 stromal keratitis, Ganciclovir Ophthalmic Gel, Valacyclovir Hydrochloride Tablets, Prednisolone Acetate Ophthalmic Suspension | Shanghai BDgene Co., Ltd. | Herpes Simplex Virus Type I Stromal Keratitis | 09/25 | 09/25 | | |
ASOTARI, NCT06451172: Novel Antisense Oligonucleotide Eye Drops for Treating Antibiotic-Resistant Bacterial Keratitis |
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| Recruiting | 1 | 20 | RoW | ASO | Eye & ENT Hospital of Fudan University, Soochow University | Bacterial Keratitis, Antibiotic-resistant Bacteria, Infections, Bacterial, Corneal Diseases, Eye Diseases, Vision Disorders, Sensation Disorders, Blindness, Antisense Peptide Nucleic Acid, Antibacterial Therapy | 10/24 | 10/26 | | |
NCT05200000: Wharton's Jelly Eye Drops in the Treatment of Chronic Keratitis |
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| Completed | 1 | 20 | Europe | SygeLIX-Coll-T | TBF Genie Tissulaire | Keratitis, Ulcerative, Corneal Ulcer | 06/23 | 06/23 | | |
NCT05268718: Au-Ag-Cu2O NG With PTT Anti Drug-resistant Microbial Keratitis |
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| Recruiting | 1 | 20 | RoW | Hollow gold and silver alloy cuprous oxide shell nano-shell hydrogel, Au-Ag-Cu2O nano-gel, Voriconazole eye drops, VRC, Normal saline, NS | Second Affiliated Hospital, School of Medicine, Zhejiang University | Keratitis, Ulcerative, Antibiotic Resistance, Microbial, Photothermal Therapy | 12/23 | 07/24 | | |
NCT06597422: A Study of STSP-0902 Ophthalmic Solution in Healthy Subjects |
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| Not yet recruiting | 1 | 80 | RoW | STSP-0902 ophthalmic solution, STSP-0902 Placebo | Staidson (Beijing) Biopharmaceuticals Co., Ltd | Neurotrophic Keratitis | 02/25 | 05/25 | | |
NCT03918408: Safety and Effectiveness of the PXL-Platinum 330 System for Corneal Cross-Linking |
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| Recruiting | 1 | 300 | US | PXL-330 Platinum device for crosslinking with Peschke ribofflavin solution, Corneal crosslinking | Pacific Clear Vision Institute | Keratoconus, Unstable, Bacterial Keratitis, Ectasia of Cornea | 12/29 | 12/30 | | |
| Completed | N/A | 208 | | Ganciclovir Ophthalmic in situ forming Gel; Ganciclovir Ophthalmic Gel | Eye and ENT Hospital of Fudan University; Eye and ENT Hospital of Fudan University, Shenyang Xingqi Pharmaceutical Co., Ltd. | Herpes Simplex Keratitis | | | | |
ChiCTR2000037247: Evaluation of the safety and efficacy of biological keratoprothesis in the treatment of infective keratitis |
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| Completed | N/A | 72 | | keratoplasty was performed using the biologic keratoprothesis | Wenzhou Medical University Eye Hospital; Wenzhou Medical University Eye Hospital, Guangzhou Youvision Biotechnology Co. Ltd. | Infectious keratitis | | | | |
ChiCTR1800018011: Efficacy of Acyclovir Combined with Dexamethasone Eye Drops in the Treatment of Recurrent Herpes Stromal Keratitis |
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| Completed | N/A | 119 | | topically administrated with 0.1% acyclovir (ACV) combined with dexamethasone (reduced from 0.06% to 0.03%) eyedrops with the stepladder approach ;topically administered with 0.1% ACV eyedrops and 0.3% tobramycin combined with 0.1% dexamethasone eyedrops | Tongji Hospital affiliated with Tongji University School of Medicine; Tongji Hospital affiliated with Tongji University School of Medicine, None | Herpetic stromal keratitis | | | | |
ChiCTR-INR-16008830: Clinical study of the low-temperature plasma surgery system for the treatment of infectious keratitis |
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| Recruiting | N/A | 150 | | low-temperature plasma (PLA) surgery system treatment ;Corneal scraping ;Antifungus medical treatment | Eye and ENT Hospital, Fudan University; Eye and ENT Hospital, Fudan University, Cost of scientific research | infectious keratitis | | | | |
ChiCTR-ONN-16009353: Pre-clinical Application Study of Novel Stem Cell to Treat Incurable Eye Disease |
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| Not yet recruiting | N/A | 180 | | No treatment ;autologous mesenchymal stem cells treatment ;eye drops ;autologous limbus stomal stem cell tratment | Shanghai Tenth People's Hospital; Shanghai Tenth People's Hospital, Developing center of Shanghai Shenkang hospital | Retinitis pigmentosa，corneal ulcer | | | | |
ChiCTR-OOC-17013709: Multi-center study of clinical features and management of viral keratitis after cataract surgery |
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| Not yet recruiting | N/A | 70 | | Nil | the Eye Hospital of Wenzhou Medical University; the Eye Hospital of Wenzhou Medical University, Supporting funds of the National Natural Science Foundation of China | viral keratitis | | | | |
NCT05123014: Lenticule Implantation and Autologous Serum New Approach in Treatment of Adenoviral Keratitis Disease |
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| Active, not recruiting | N/A | 45 | RoW | relex smile | Eye Hospital Pristina Kosovo | Adenoviral Keratoconjunctivitis | 02/19 | 02/25 | | |
ChiCTR1900023720: Evaluation of the feasibility of applying internal transcribed spacer identification (ITSI) as a complementary-method in the diagnosis of fungal keratitis |
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| Not yet recruiting | N/A | | | | Qingdao Eye Hospital; Qingdao Eye Hospital, Shandong Province Major Science and Technology Innovation Project | Fungal keratitis | | | | |
ChiCTR1900023651: Study for Bacterial Polymorphism in Ocular Surface with Bacterial Keratitis |
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| Not yet recruiting | N/A | 32 | | collect cotton swab samples | Qingdao Eye Hospital; Qingdao Eye Hospital, National Natural Science Foudation of China | Bacterial Keratitis | | | | |
ChiCTR-ONC-17013979: Evaluation of the efficacy and safety of acellular porcine corneal matrix cornea for the treatment of ineffective non-perforated corneal ulcer |
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| Recruiting | N/A | 100 | | acellular corneal stroma corneal transplantation | 2nd Affiliated Hospital, Zhejiang University, School of Medicine; 2nd Affiliated hospital, Zhejiang University, School of Medicine, no | Corneal ulcer | | | | |
ChiCTR1900026147: Clinical observation for the effect of corneal crosslinking combined with keratoplasty in the treatment of acanthamoeba keratitis |
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| Recruiting | N/A | 15 | | corneal crosslinking | Shandong Eye Hospital; Shandong Eye Hospital, money from the patient himself | Acanthamoeba keratitis | | | | |
| Enrolling by invitation | N/A | 35 | RoW | Relex-Smile | Eye Hospital Pristina Kosovo | Stromal Keratitis | 01/20 | 01/25 | | |
NCT05809245: Corneal Neurotization as a Treatment for Neurotrophic Keratopathy |
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| Terminated | N/A | 4 | US | Corneal neurotization | Stanford University | Neurotrophic Corneal Ulcer, Neurotrophic Keratitis, Cranial Nerve V Diseases | 02/20 | 02/20 | | |
ChiCTR2000032542: Evaluation of Alterations about Microbiome between Healthy and Microbial Keratitis Ocular Surface and the Feasibility of Combining High Throughput Sequencing with Artificial Intelligence to Distinguish Microbial Keratitis |
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| Not yet recruiting | N/A | 200 | | Nil | State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Shandong First Medical University & Shandong Academy of Medical Sciences; Qingdao Eye Hospital, the Key Science and Technology Innovation Project of Shandong Province (2018CXGC1205), the Taishan Scholar Program (ts20190983), National Natural Science Foundation of China (81970788) | Microbial Keratitis | | | | |
ChiCTR2000031875: To evaluate the characteristics of bacterial flora on the ocular surface of healthy and different types of infectious keratitis and the feasibility of using high-throughput sequencing technology combined with artificial intelligence as a supplementary diagnostic method for infectious keratitis |
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| Not yet recruiting | N/A | 200 | | None ;Nil | Shandong First Medical University (Shandong Academy of Medical Sciences) Shandong Institute of Ophthalmology; Key Laboratory of Ophthalmology of Shandong Province - national key laboratory cultivation; Qingdao Eye Hospital, the Key Science and Technology Innovation Project of Shandong Province (2018CXGC1205), the Taishan Scholar Program (ts20190983), National Natural Science Foundation of China (81970788) | Microbial Keratitis | | | | |
| Not yet recruiting | N/A | 120 | NA | Corneal impression membrane (Millicell Cell Culture Insert, 12mm, hydrophilic PTFE 0.4µm (PICM01250)) | University of Edinburgh | Corneal Ulcer (Diagnosis) | 02/26 | 02/26 | | |
| Recruiting | N/A | 60 | | Nil ;Nil | The first affiliated Hospital of Northwestern University, Xi'an No.1 Hospital; Xi'an No.1 Hospital, Researcher funds | Infectious keratitis | | | | |
ChiCTR1900027108: Study for the safety and efficacy of hypochlorite eye drops in the treatment of infectious keratitis |
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| Recruiting | N/A | 200 | | 抗生素滴眼 Antibiotic eye drops ;Antibiotics + Hypochlorite Eye Drops ;Antifungal drugs ;Antifungal Drugs + Hypochlorite Eye Drops | Affiliated Hospital of Xuzhou Medical University; Affiliated Hospital of Xuzhou Medical University, Doctoral Research Initiation Funds | Infectious keratitis | | | | |
| Recruiting | N/A | 800 | Europe | | University Hospital, Montpellier | Corneal Diseases, Keratoconus, Corneal Ulcer, Corneal Trauma, Corneal Dystrophies | 12/21 | 12/21 | | |
ChiCTR2100044068: Relationship between Corneal Sensation, Blinking and Tear Film in Patients with Neurotrophic Keratitis |
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| Recruiting | N/A | 60 | | none ;none | Tianjin Medical University Eye Hospital; Tianjin Medical University Eye Hospital, Project funding | Neurotrophic Keratitis | | | | |
NCT04969640: Role of Anterior Segment Optical Coherence Tomography in Infectious Keratitis |
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| Completed | N/A | 23 | RoW | Optical coherence tomography | Minia University | Infective Keratitis | 12/21 | 12/21 | | |
ChiCTR2000040372: Bilateral Limbal Stem Cells alterations in patients with unilateral herpes simplex keratitis with in vivo confocal microscopy clinical study |
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| Recruiting | N/A | 150 | | Nil | First Ward in Department of Ophthalmology, the First Affiliated Hospital of Harbin Medical University; First Ward in Department of Ophthalmology, the First Affiliated Hospital of Harbin Medical University, Harbin, China, None | infectious keratitis | | | | |
ChiCTR2000040565: Clinical changes in the contralateral unaffected eyes of patients with unilateral infectious keratitis: An in vivo confocal microscopy study |
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| Completed | N/A | 90 | | No | Department of Ophthalmology, the First Affiliated Hospital of Harbin Medical University; the First Affiliated Hospital of Harbin Medical University, None | infectious keratitis | | | | |
| Not yet recruiting | N/A | 20 | NA | Crosslinking with Riboflavin and UV-A | Assiut University | Infectious Keratitis | 01/22 | 01/23 | | |
ChiCTR2100046030: Evaluation of changes of conjunctiva associated lymphoid tissue in eye diseases by in vivo confocal microscopy |
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| Recruiting | N/A | 200 | | N/A ;Nil | Eye Hospital, the First Affiliated Hospital of Harbin Medical University; Eye Hospital, the First Affiliated Hospital of Harbin Medical University, self-raised | Keratitis, diabetes,cornea transplantation, MGD, pterygium | | | | |
ChiCTR2100044767: An observational study on the QAC gene carrying rate of common pathogenic bacteria isolated from conjunctival sac in children orthokeratology wearers in Wenzhou |
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| Recruiting | N/A | 258 | | Nil ;Nil ;Nil | Eye Hospital Affiliated to Wenzhou Medical University; Eye Hospital Affiliated to Wenzhou Medical University, Research group funds | Microbial keratitis | | | | |
ChiCTR2100050565: Effectiveness of Continuous Infusion of Voriconazole combined with topical medication therapy in the management of moderate to severe fungal keratitis |
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| Recruiting | N/A | 80 | | Continuous Infusion of Voriconazole combined with topical medication therapy ;topical medication therapy | The Second Xiangya Hospital, Central South University; The Second Xiangya Hospital, Central South University, self-raising fund | fungal keratitis | | | | |
NCT05924893: The Use of Naltrexone Hydrochloride to Promote Healing in Patients With Resistant Non-infectious Corneal Ulcer |
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| Completed | N/A | 50 | RoW | Naltrexone Hydrochloride, NTX, Carboxy methyl cellulose, Carboxy methyl cellulose sodium 0.5% | Minia University | Cornea Ulcer | 06/22 | 12/22 | | |
ChiCTR2100044197: The efficacy and safety of foscarnet in the management of refractory herpes simplex virus keratitis: a prospective multicentric controlled study |
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| Recruiting | N/A | 50 | | Foscarnet ( IV.) ;acyclovir（IV.） | School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University; School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, National key research and development project | herpes simplex virus keratitis | | | | |
NCT05655689: The Antibiogram and Outcomes of Antimicrobial Regimens in Microbial Keratitis: A Prospective Cohort Study |
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| Completed | N/A | 123 | RoW | Moxifloxacin Ophthalmic 0.5% Ophthalmic Solution, Vigamox®, Ceftazidime 5% + vancomycin 5%, (CAZ-VAN), Gentamicin 1.4% + vancomycin 5%, (GEN-VAN), Natamycin 5% Oph Susp, Voriconazole 1%, Vfend®, Natamycin 5% + voriconazole 1%, (NT-VRC), Natamycin 5%+ ceftazidime 5% + vancomycin 5%, (NT-CAZ-VAN), Voriconazole 1% + ceftazidime 5% + vancomycin 5%, (VRC-CAZ-VAN) | Alexandria University | Bacterial Keratitis, Fungal Keratitis, Mixed Bacterial and Fungal Keratitis, Microbial Keratitis | 01/23 | 01/23 | | |
NCT04573647: OCT Evaluation of Neurotrophic Ulcer Following Treatment With Oxervate |
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| Recruiting | N/A | 10 | US | Cenegermin-Bkbj 0.002% Ophthalmic Solution [OXERVATE] | Sight Medical Doctors PLLC, Dompé, US, Inc. | Neurotrophic Ulcer, Neurotrophic Keratitis, Neurotrophic Corneal Ulcer, Neurotrophic Keratoconjunctivitis | 06/24 | 12/24 | | |
ChiCTR2200065031: New onset of herpes simplex keratitis after keratoplasty: Discussion on clinical characteristics and virus source |
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| Not yet recruiting | N/A | 19 | | None | Qingdao Eye Hospital of Shandong First Medical University; Qingdao Eye Hospital of Shandong First Medical University, Raise independently | New onset of herpes simplex keratitis after keratoplasty | | | | |
ChiCTR2000033968: A randomized, blind, and positive controlled clinical trial to evaluate the safety and efficacy of 1% voriconazole eye drops in the treatment of fungal keratitis |
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| Recruiting | N/A | 144 | | 1% voriconazole eye drops ;Natamycin eye drops | Shenyang Sinqi Eye Hospital Co., Ltd; Shenyang Sinqi Eye Hospital Co., Ltd, Shenyang SinQi Eye Hospital Co., Ltd | Fungal keratitis | | | | |
ChiCTR2000034467: Clinical research on innovative treatment of fungal keratitis: a randomized controlled trial. |
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| Recruiting | N/A | 174 | | Conventional medication ;Corneal collagen cross-linking ;Continuous ocular lavage with antifungal | Beijing Aier Intech Eye Hospital; Beijing Aier Intech Eye Hospital, Capital Health Development Research Special Fund, Beijing Aier Intech Eye Hospital | Fungal keratitis | | | | |
| Completed | N/A | 55 | US | Lotrafilcon A contact lenses, AONDA, AIR OPTIX® NIGHT & DAY® AQUA | Alcon Research | Bullous Keratopathy, Corneal Erosion, Entropion, Corneal Edema, Corneal Dystrophy, Corneal Ulcer, Foreign Body in Cornea, Bell Palsy, Keratoconjunctivitis, Filamentary Keratitis, Sicca Syndrome; Keratoconjunctivitis (Etiology) | 07/23 | 07/23 | | |
NCT05940376: Topical Insulin in Neurotrophic Keratopathy After Diabetic Vitrectomy |
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| Not yet recruiting | N/A | 30 | RoW | rapid acting insulin | Benha University | Corneal Ulcer, Neurotrophic Corneal Ulcer, Diabetes Mellitus | 08/23 | 08/23 | | |
NCT06364878: Non-invasive Diagnostics of Microbial Keratitis |
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| Recruiting | N/A | 125 | Europe | In vivo confocal microscopy, IVCM, Tear film sampling | Sorlandet Hospital HF | Infectious Keratitis | 03/25 | 04/28 | | |
NCT03461978: Ultrahigh-resolution Optical Coherence Tomography Imaging of the Anterior Eye Segment Structures |
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| Enrolling by invitation | N/A | 60 | Europe | Ultrahigh resolution Spectral Domain OCT | Medical University of Vienna | Meibomian Gland Dysfunction, Cataract, Glaucoma, Corneal Transplantation, Demodicosis, Conjunctival Pathologies, Acanthamoeba Keratitis, Aniridia | 09/23 | 10/23 | | |
NCT06070883: Efficacy of Mutilayered Fresh Amnoitic Membrane Transplantation in Resistant Fungal Keratitis |
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| Completed | N/A | 26 | RoW | Amniotic membrane transplantation | Al-Azhar University | Keratitis | 09/23 | 10/23 | | |
NCT05538793: Deep Learning for the Discrimination Among Different Types of Keratits: a Nationwide Study |
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| Completed | N/A | 10369 | RoW | | Ningbo Eye Hospital | Keratitis, Automatic Judgement, Image | 09/23 | 10/23 | | |
ChiCTR2200064658: A preliminary study on the treatment of epithelial simplex virus keratitis based on confocal microscopy |
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| Not yet recruiting | N/A | 46 | | Conventional treatment plus 0.05% cyclosporine eye drops ;Conventional therapy | Wuhan Aier Ophthalmology Hanyang Hospital; Wuhan Aier Ophthalmology Hanyang Hospital, Aier Eye Hospital Group Research Fund | Epithelial herpes simplex keratitis | | | | |
PROSIKA, NCT04701086: 3 Month Study of Cationorm Pro Versus Vismed in Adults With Dry Eye Disease Related to Keratitis or Keratoconjunctivitis |
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| Recruiting | N/A | 80 | Europe | Cationorm Pro, Ocutears Pro+, Vismed | Santen SAS | Dry Eye Syndromes | 12/24 | 12/24 | | |
| Enrolling by invitation | N/A | 108 | US | Quantitative Sensory Test | Tufts Medical Center, Dompé Farmaceutici S.p.A | Corneal Disease, Neuropathy, Dry Eye Disease, Neurotrophic Keratitis | 10/24 | 06/25 | | |
NCT06229379: The Effects of a Large Language Model on Clinical Questioning Skills |
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| Completed | N/A | 84 | RoW | "Digital twin patient", Interaction with real patients | Sun Yat-sen University | Cataract, Glaucoma, Diabetic Retinopathy, Keratitis, Conjunctivitis | 05/24 | 08/24 | | |
| Active, not recruiting | N/A | 223671 | RoW | Corneal ulcer prevention program | University of California, San Francisco, National Eye Institute (NEI), Seva Foundation, Bharatpur Eye Hospital | Corneal Ulcer | 01/25 | 01/25 | | |
| Active, not recruiting | N/A | 40 | US | Cenegermin Ophthalmic Solution [Oxervate] | University of California, Los Angeles, Dompé Farmaceutici S.p.A | Neurotrophic Keratitis | 02/25 | 02/25 | | |
ALHENA, NCT04685109: 3 Month Study of Alocross Versus Vismed in Adults With Dry Eye Disease Related to Keratitis or Keratoconjunctivitis |
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| Recruiting | N/A | 80 | Europe | Alocross 0.2% Unit Dose, Vismed, HA 0.18% hypotonic solution | Santen SAS | Dry Eye Syndromes | 12/24 | 12/24 | | |
ChiCTR2300074054: Validation of a symptom management program for patients with corneal ulcer |
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| Not yet recruiting | N/A | 76 | | Mobile Health Management ;usual care | The First Affiliated Hospital of Army Medical University; The First Affiliated Hospital of Army Medical University, Military Nursing Innovation and Cultivation Special Program（2021HL010） | Corneal ulcer | | | | |
NCT06540131: Studying the Effect of Ethanol Applied on the Corneal Surface During PRK Surgery. |
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| Completed | N/A | 70 | RoW | | Minia University | Corneal Ulcer of Bilateral Eyes | 06/24 | 06/24 | | |
| Not yet recruiting | N/A | 60 | RoW | Riboflavin, Antibotice.g vigamox ED Antifungal e.g Dflucan, pack cross linking | Sohag University | Infectoius Keratitis | 04/24 | 06/24 | | |
VICTORIA, NCT05620264: Validation of Interleukins and Other Cytokines Together With OCT Imaging for Rapid Infectious Keratitis Assessment |
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| Recruiting | N/A | 392 | Europe | Tear Sample Probe | Johannes Kepler University of Linz | Keratitis Bacterial, Keratitis Fungal | 04/24 | 10/24 | | |
| Not yet recruiting | N/A | 151 | NA | | IRCCS Ospedale San Raffaele | Acanthamoeba Keratitis, Artificial Intelligence | 10/24 | 04/25 | | |
| Not yet recruiting | N/A | 80 | | Collect conjunctival sac swab | Eye Hospital, Wenzhou Medical University; Eye Hospital, Wenzhou Medical University, temporary absence | infectious keratitis | | | | |
| Recruiting | N/A | 700 | US, RoW | Visual Acuity | University of Michigan, National Eye Institute (NEI) | Keratitis | 07/24 | 07/24 | | |
IIR, NCT06364657: Differences in Corneal Structure and Function in Patients With Sjogrens vs. Non-Sjogrens Dry Eye |
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| Recruiting | N/A | 120 | US | Eye Exam | Johns Hopkins University, Dompe U.S. Inc | Sjogren's Syndrome, Dry Eye, Neurotrophic Keratitis | 07/25 | 07/27 | | |
ChiCTR2200061595: Correlation between corneal neuromorphology and corneal sensitivity in different stages of herpes simplex virus keratitis |
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| Not yet recruiting | N/A | 30 | | None ;None | Qingdao Eye Hospital, Shandong Eye Institute, Shandong First Medical University & Shandong Academy of Medical Science; Qingdao Eye Hospital, Open project of Qingdao Eye Hospital | Kerotoplasty | | | | |
| Completed | N/A | 24 | US | Cenegemin in the DEFENDO Study, OXERVATE™ | Dompé Farmaceutici S.p.A | Neurotrophic Keratitis | 04/24 | 04/24 | | |
NCT06641882: Retrospective Chart Review of Patients with Acanthamoeba Keratitis Who Have Received 0.8 Mg/ml Polihexanide |
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| Recruiting | N/A | 40 | Europe | | SIFI SpA | Acanthamoeba Keratitis | 12/24 | 12/24 | | |
| Recruiting | N/A | 149 | Europe | NGS for endohtalmitis / Multiplex PCR for keratitis, Bundle of intervervention to optimizing diagnosis of ocular complex infections | Assistance Publique - Hôpitaux de Paris | Endophthalmitis, Keratitis | 11/24 | 05/25 | | |
NCT04700657: The Prevalence of Hypoesthesia Related Keratitis in Ocular Graft Vs. Host Disease (GVHD) Patients |
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| Recruiting | N/A | 30 | US | corneal sensation test | Indiana University | Ocular GVHD | 12/26 | 12/26 | | |
NCT05888883: Microbial Keratitis Sampling for Biomarker Discovery |
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| Recruiting | N/A | 70 | Europe | | University of Edinburgh, NHS Lothian | Microbial Keratitis | 12/24 | 03/28 | | |
ChiCTR1900027014: Application of SMILE lenticule tissue in the treatment of corneal diseases |
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| Not yet recruiting | N/A | 125 | | none ;none ;none ;none | Shandong Eye Instiute, Qingdao Eye Hospital; Shandong Eye Instiute, Qingdao Eye Hospital, none | Keratoconus, corneal dystrophy, corneal ulcer, corneal trauma | | | | |
ChiCTR2100043003: Etiological diagnosis and image marker mining of infectious keratitis based on multimodal ocular surface image |
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| Not yet recruiting | N/A | | | | GuangDong Provincial People’s hospital（GuangDong Academy of Medical Sciences）; GuangDong Provincial People’s hospital（GuangDong Academy of Medical Sciences）, Research fuding | Infectious keratitis | | | | |
| Recruiting | N/A | 46 | Europe | PCR multiplex by FilmArray | CHU de Reims | Infectious Keratitis, Microbial Keratitis, Corneal Infection | 01/27 | 08/27 | | |
