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128 Companies |
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121 Products |
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121 Products |
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104 Mechanisms of Action |
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7 Trials |
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1812 News |
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- Trial completion, Metastases: FLOT3: Prospective Study With FLOT in Patients With Locally Advanced, Limited Metastatic or Extensive Metastatic Adenocarcinoma of the Stomach or Esophagogastric Junction (clinicaltrials.gov) - Feb 3, 2016
P2, N=252, Completed, Sponsor: Krankenhaus Nordwest
Active, not recruiting --> Completed
- metformin / Generic mfg., omeprazole / Generic mfg.
Enrollment closed, Enrollment change, Trial primary completion date, IO biomarker: Vitamin D Supplementation on 15-Prostaglandin Dehydrogenase Expression in Barrett's Esophagus (clinicaltrials.gov) - Feb 2, 2016
P0, N=26, Active, not recruiting, Sponsor: Case Comprehensive Cancer Center
Active, not recruiting --> Completed Recruiting --> Active, not recruiting | N=66 --> 26 | Trial primary completion date: Jun 2016 --> Feb 2016
- |||||||||| esomeprazole / Generic mfg.
New P3 trial: NEED: Open, Randomised, Multi-center Study of on Demand Versus Continuous Esomeprazole Treatment in Patient With GERD (clinicaltrials.gov) - Feb 2, 2016
P3, N=877, Completed, Sponsor: AstraZeneca
- octreotide acetate solution for injection / Generic mfg.
Enrollment change, Trial primary completion date, Surgery: Food Intake and Gut Hormones in Patients Who Have Undergone Upper Gastrointestinal Surgery for Cancer (clinicaltrials.gov) - Feb 2, 2016
P=N/A, N=80, Enrolling by invitation, Sponsor: St. James's Hospital, Ireland
Recruiting --> Active, not recruiting | N=66 --> 26 | Trial primary completion date: Jun 2016 --> Feb 2016 N=35 --> 80 | Trial primary completion date: Dec 2015 --> Dec 2017
- octreotide acetate solution for injection / Generic mfg.
Enrollment change, Trial primary completion date, Surgery: The Effect of Satiety Gut Hormone Modulation on Appetitive Drive After Upper Gastrointestinal Surgery (clinicaltrials.gov) - Feb 2, 2016
P=N/A, N=80, Enrolling by invitation, Sponsor: St. James's Hospital, Ireland
N=35 --> 80 | Trial primary completion date: Dec 2015 --> Dec 2017 N=36 --> 80 | Trial primary completion date: Mar 2016 --> Mar 2018
- Trial completion, Trial primary completion date: A Pilot Study of Acupuncture Treatment for Dysphagia (clinicaltrials.gov) - Jan 30, 2016
P=N/A, N=42, Completed, Sponsor: Dana-Farber Cancer Institute
N=36 --> 80 | Trial primary completion date: Mar 2016 --> Mar 2018 Active, not recruiting --> Completed | Trial primary completion date: Feb 2014 --> Aug 2015
- Trial completion: Study to Identify Non-Invasive Markers of Gastrointestinal Allergy (clinicaltrials.gov) - Jan 27, 2016
P1, N=110, Completed, Sponsor: Children's Hospital Boston
Active, not recruiting --> Completed | Trial primary completion date: Feb 2014 --> Aug 2015 Recruiting --> Completed
- Enrollment closed: A Validation Study of the Dx-pH Probe in Children for the Detection of Extra-oesophageal Reflux (clinicaltrials.gov) - Jan 27, 2016
P=N/A, N=30, Active, not recruiting, Sponsor: Central Manchester University Hospitals NHS Foundation Trust
Recruiting --> Completed Recruiting --> Active, not recruiting
- ||| Enrollment open: Proton Pump Inhibitor Empirical Treatment in Management of Outpatients With Gastroesophageal Reflux Disease. (clinicaltrials.gov) - Jan 27, 2016
P=N/A, N=1000, Recruiting, Sponsor: AstraZeneca
Recruiting --> Active, not recruiting Not yet recruiting --> Recruiting
- Enrollment open: NUTRIENTII: Nutritional Route In Esophageal Resection Trial II (clinicaltrials.gov) - Jan 27, 2016
P=N/A, N=148, Enrolling by invitation, Sponsor: Catharina Ziekenhuis Eindhoven
Not yet recruiting --> Recruiting Not yet recruiting --> Enrolling by invitation
- New P2 trial: Peroral Endoscopic Myotomy Versus Botulinum Toxin Injection in Spastic Esophageal Disorders (clinicaltrials.gov) - Jan 26, 2016
P2, N=50, Recruiting, Sponsor: Johns Hopkins University
- metformin / Generic mfg., omeprazole / Generic mfg.
Trial primary completion date, IO biomarker: Vitamin D Supplementation on 15-Prostaglandin Dehydrogenase Expression in Barrett's Esophagus (clinicaltrials.gov) - Jan 22, 2016
P0, N=66, Recruiting, Sponsor: Case Comprehensive Cancer Center
Not yet recruiting --> Enrolling by invitation Trial primary completion date: Dec 2015 --> Jun 2016
- || Trial primary completion date: Trial of XELOX Followed by Radiation Combined With Carboplatin and RAD001 for Esophageal Cancer (clinicaltrials.gov) - Jan 21, 2016
P1/2, N=63, Recruiting, Sponsor: Emory University
Trial primary completion date: Dec 2015 --> Jun 2016 Trial primary completion date: Feb 2016 --> Feb 2017
- esomeprazole / Generic mfg.
Phase classification, Trial primary completion date: Effect of Acid Reflux on Respiratory Physiology During Exercise in Athletes With GER-Response to Acid Suppression (clinicaltrials.gov) - Jan 21, 2016
P1, N=31, Terminated, Sponsor: University of Utah
Trial primary completion date: Feb 2016 --> Feb 2017 Phase classification: P=N/A --> P1 | Trial primary completion date: Jul 2013 --> Sep 2009
- |||||| Jorveza (budesonide orodispersible tablets) / Dr Falk
Enrollment open, Trial initiation date, Trial primary completion date: EOS-1: Budesonide Orodispersible Tablet vs. Placebo in Active Eosinophilic Esophagitis (clinicaltrials.gov) - Jan 21, 2016
P3, N=90, Recruiting, Sponsor: Dr. Falk Pharma GmbH
Phase classification: P=N/A --> P1 | Trial primary completion date: Jul 2013 --> Sep 2009 Not yet recruiting --> Recruiting | Initiation date: May 2015 --> Nov 2015 | Trial primary completion date: Mar 2017 --> Sep 2017
- Trial primary completion date, Reflex: Cough Reflex Sensitivity and Bronchial Hyper-responsiveness (clinicaltrials.gov) - Jan 21, 2016
P=N/A, N=36, Recruiting, Sponsor: Mayo Clinic
Not yet recruiting --> Recruiting | Initiation date: May 2015 --> Nov 2015 | Trial primary completion date: Mar 2017 --> Sep 2017 Trial primary completion date: Dec 2015 --> Dec 2016
- Trial completion, Enrollment change: Can We Predict Who Has Gastroesophageal Reflux Disease (GERD)? (clinicaltrials.gov) - Jan 21, 2016
P=N/A, N=254, Completed, Sponsor: Vanderbilt University
Trial primary completion date: Dec 2015 --> Dec 2016 Active, not recruiting --> Completed | N=210 --> 254
- Trial primary completion date: ProdDiGYPark: Study of Dysarthria, Swallowing Disorders and Respiratory in Parkinson's Disease (clinicaltrials.gov) - Jan 20, 2016
P=N/A, N=64, Recruiting, Sponsor: University Hospital, Lille
Active, not recruiting --> Completed | N=210 --> 254 Trial primary completion date: Dec 2015 --> Dec 2017
- Trial primary completion date: Assessment of Esophageal Epithelium Integrity With Mucosal Impedance (clinicaltrials.gov) - Jan 20, 2016
P=N/A, N=40, Active, not recruiting, Sponsor: Vanderbilt University
Trial primary completion date: Dec 2015 --> Dec 2017 Trial primary completion date: Jan 2014 --> Apr 2016
- New trial: Head and Neck Cancer Treatment Related Dysphagia (clinicaltrials.gov) - Jan 19, 2016
P=N/A, N=250, Not yet recruiting, Sponsor: Sidney Kimmel Comprehensive Cancer Center
- || Preclinical, Trial primary completion date: PEPTESTCN: Validation of a Non-invasive In-vitro Diagnostic Test (Peptest) Against Other Diagnostic Methods for GERD (clinicaltrials.gov) - Jan 18, 2016
P=N/A, N=1020, Recruiting, Sponsor: MAAB (Shanghai) Medical Device Limited
Trial primary completion date: Jan 2014 --> Apr 2016 Trial primary completion date: Oct 2015 --> Apr 2016
- Trial primary completion date: Esophageal Absorption in EoE (clinicaltrials.gov) - Jan 18, 2016
P=N/A, N=40, Recruiting, Sponsor: Mayo Clinic
Trial primary completion date: Oct 2015 --> Apr 2016 Trial primary completion date: Dec 2015 --> Nov 2016
- Trial primary completion date: SIRUP: Stretta In Reflux Uncontrolled by IPP (clinicaltrials.gov) - Jan 18, 2016
P=N/A, N=60, Recruiting, Sponsor: Nantes University Hospital
Trial primary completion date: Dec 2015 --> Nov 2016 Trial primary completion date: Sep 2016 --> Jun 2018
- Folotyn (pralatrexate) / Aurobindo
Trial completion, Combination therapy, Metastases: Pralatrexate and Oxaliplatin in Treating Patients With Unresectable or Metastatic Esophageal, Stomach, or Gastroesophageal Junction Cancer (clinicaltrials.gov) - Jan 16, 2016
P2, N=35, Completed, Sponsor: Roswell Park Cancer Institute
Trial primary completion date: Sep 2016 --> Jun 2018 Active, not recruiting --> Completed
- Trial termination: Bethanechol for Eosinophilic Esophagitis (clinicaltrials.gov) - Jan 15, 2016
P2, N=2, Terminated, Sponsor: University of Iowa
Active, not recruiting --> Completed Completed --> Terminated; Initial PI left, study not continued
- Trial completion, Enrollment change: Development and Validation of the Automated Evaluation of Gastrointestinal Symptoms (AEGIS) Platform (clinicaltrials.gov) - Jan 15, 2016
P=N/A, N=255, Completed, Sponsor: Cedars-Sinai Medical Center
Completed --> Terminated; Initial PI left, study not continued Recruiting --> Completed | N=200 --> 255
- Xpovio (selinexor) / Karyopharm, Menarini, FORUS Therap
Enrollment change, Trial termination, Trial primary completion date, Combination therapy: Selinexor in Combination With Irinotecan in Adenocarcinoma of Stomach and Distal Esophagus (clinicaltrials.gov) - Jan 15, 2016
P1, N=3, Terminated, Sponsor: H. Lee Moffitt Cancer Center and Research Institute
Recruiting --> Completed | N=200 --> 255 N=35 --> 3 | Recruiting --> Terminated | Trial primary completion date: Dec 2018 --> Dec 2015; Principal Investigator left the institution
- || Enrollment change, Trial primary completion date: Pillars4Life Trial (clinicaltrials.gov) - Jan 15, 2016
P=N/A, N=250, Recruiting, Sponsor: Duke University
N=35 --> 3 | Recruiting --> Terminated | Trial primary completion date: Dec 2018 --> Dec 2015; Principal Investigator left the institution N=180 --> 250 | Trial primary completion date: Dec 2015 --> Jun 2016
- Trial completion, Enrollment change, Trial primary completion date: Scleroderma Lung: Role of Gastroesophageal Reflux, Microaspiration and Cough (clinicaltrials.gov) - Jan 11, 2016
P=N/A, N=7, Completed, Sponsor: Mayo Clinic
N=180 --> 250 | Trial primary completion date: Dec 2015 --> Jun 2016 Recruiting --> Completed | N=12 --> 7 | Trial primary completion date: Dec 2016 --> Jun 2014
- Trial completion, Enrollment change: Endoscopic Multispectral Imaging for the Early Detection of Barrett's Neoplasia (clinicaltrials.gov) - Jan 11, 2016
P0, N=30, Completed, Sponsor: Anandasabapathy, Sharmila, M.D.
Recruiting --> Completed | N=12 --> 7 | Trial primary completion date: Dec 2016 --> Jun 2014 Recruiting --> Completed | N=50 --> 30
- Trial completion: Minimal Injuries From Esophagus Detected by Optical Enhancement System™ Associated to Optical Magnification HD Scopes (clinicaltrials.gov) - Jan 11, 2016
P=N/A, N=100, Completed, Sponsor: Instituto Ecuatoriano de Enfermedades Digestivas
Recruiting --> Completed | N=50 --> 30 Recruiting --> Completed
- Teysuno (gimeracil/oteracil/tegafur) / Nordic Group, Otsuka
Enrollment closed, Trial primary completion date, Combination therapy: Study of S-1 in Combination With Radiotherapy in Esophageal Cancer (clinicaltrials.gov) - Jan 8, 2016
P2, N=105, Active, not recruiting, Sponsor: Fudan University
Recruiting --> Completed Recruiting --> Active, not recruiting | Trial primary completion date: Mar 2015 --> Oct 2018
- | 5-fluorouracil / Generic mfg., cisplatin / Generic mfg., paclitaxel / Generic mfg.
Enrollment closed, Trial primary completion date, Metastases: A Phase III Study of Comparing Paclitaxel Plus 5-Fluorouracil Versus Cisplatin Plus 5-Fluorouracil in Chemoradiotherapy for Locally Advanced Esophageal Carcinoma (clinicaltrials.gov) - Jan 7, 2016
P3, N=436, Active, not recruiting, Sponsor: Fudan University
Recruiting --> Active, not recruiting | Trial primary completion date: Mar 2015 --> Oct 2018 Recruiting --> Active, not recruiting | Trial primary completion date: Apr 2014 --> Jul 2018
- New trial: The Role of Therapy for Muscle Tension Dysphagia (clinicaltrials.gov) - Jan 6, 2016
P=N/A, N=120, Recruiting, Sponsor: Mayo Clinic
- ||| Trial completion, HEOR: Dysphagia Handicap Index: A Structured Translation From English to German (clinicaltrials.gov) - Jan 6, 2016
P=N/A, N=130, Completed, Sponsor: University of Zurich
Recruiting --> Active, not recruiting | Trial primary completion date: Apr 2014 --> Jul 2018 Recruiting --> Completed
- Trial completion, Trial initiation date: Injection of Cyanoacrylate+Lipiodol vs Cyanoacrylate+Lauromacrogol in Gastric Varices (clinicaltrials.gov) - Jan 6, 2016
P=N/A, N=96, Completed, Sponsor: Shanghai Zhongshan Hospital
Recruiting --> Completed Recruiting --> Completed | Initiation date: Apr 2013 --> Oct 2013
- | Enrollment open: Eosinophilic Esophagitis Intervention Trial-1 Food vs. 4 Food Elimination Diet Followed by Swallowed Glucocorticoids (clinicaltrials.gov) - Jan 5, 2016
P2/3, N=292, Recruiting, Sponsor: Children's Hospital Medical Center, Cincinnati
Recruiting --> Completed | Initiation date: Apr 2013 --> Oct 2013 Not yet recruiting --> Recruiting
- Trial completion: DYnAMICS: DYsphAgia In Mechanically Ventilated ICU patientS (clinicaltrials.gov) - Jan 4, 2016
P=N/A, N=2000, Completed, Sponsor: University Hospital Inselspital, Berne
Not yet recruiting --> Recruiting Recruiting --> Completed
- Enrollment open: Influence of Intrapulmonary Percussive Ventilation (IPV) on Gastro-oesophageal Reflux (GOR). (clinicaltrials.gov) - Jan 1, 2016
P=N/A, N=50, Recruiting, Sponsor: Vrije Universiteit Brussel
Recruiting --> Completed Not yet recruiting --> Recruiting
- Trial completion, Bariatric surgery: Laparoscopic Roux-en-Y Gastric Bypass and Gastro-esophageal Reflux (clinicaltrials.gov) - Dec 31, 2015
P=N/A, N=86, Completed, Sponsor: University of Turin, Italy
Not yet recruiting --> Recruiting Not yet recruiting --> Completed
- Trial completion, Trial primary completion date: The Effects of Cold Liquids on the Swallowing Mechanism in Preterm Infants (clinicaltrials.gov) - Dec 30, 2015
P=N/A, N=10, Completed, Sponsor: Winthrop University Hospital
Not yet recruiting --> Completed Recruiting --> Completed | Trial primary completion date: Aug 2015 --> Dec 2015
- cisplatin / Generic mfg., capecitabine / Generic mfg.
Enrollment change, Metastases: Phase II Trial of XP Versus XG in Advanced Esophageal Squamous Cell Carcinoma (clinicaltrials.gov) - Dec 29, 2015
P2, N=64, Completed, Sponsor: Samsung Medical Center
Recruiting --> Completed | Trial primary completion date: Aug 2015 --> Dec 2015 N=94 --> 64
- docetaxel / Generic mfg., gemcitabine / Generic mfg.
Trial completion, Enrollment change, Metastases: Study of Docetaxel and Gemcitabine in Metastatic Esophageal Squamous Cell Cancer (clinicaltrials.gov) - Dec 29, 2015
P2, N=24, Completed, Sponsor: Samsung Medical Center
N=94 --> 64 Active, not recruiting --> Completed | N=32 --> 24
- Trial termination, Bariatric surgery: Effect of RING on Gastroesophageal Reflux (GERD) After RYGBP (clinicaltrials.gov) - Dec 23, 2015
P=N/A, N=114, Terminated, Sponsor: Clinica Gastrobese
Active, not recruiting --> Completed | N=32 --> 24 Active, not recruiting --> Terminated; lack of follow up
- Trial suspension: Cognitive-Behavioral Intervention for Worry, Uncertainty, and Insomnia for Cancer Survivors (clinicaltrials.gov) - Dec 23, 2015
P=N/A, N=75, Suspended, Sponsor: Ohio State University Comprehensive Cancer Center
Active, not recruiting --> Terminated; lack of follow up Active, not recruiting --> Suspended
- | Zykadia (ceritinib) / Novartis
New P2 trial: Study of Oral Ceritinib in Patients With ALK and ROS1 Activated Gastrointestinal Malignancies (clinicaltrials.gov) - Dec 23, 2015
P2, N=30, Not yet recruiting, Sponsor: Criterium, Inc.
- Nasonex (mometasone furoate nasal spray) / Merck (MSD)
Enrollment open, Trial primary completion date: Mometasone-furoate for Treatment of Eosinophilic Esophagitis - a Randomized Placebo Controlled Study. (clinicaltrials.gov) - Dec 21, 2015
P2, N=42, Enrolling by invitation, Sponsor: Mogens Bove
Active, not recruiting --> Suspended Not yet recruiting --> Enrolling by invitation | Trial primary completion date: Mar 2015 --> Dec 2017
- Enrollment change, Trial termination, Trial primary completion date: Molecular Phenotyping in Predicting Response in Patients With Stage IB-III Esophageal Cancer Receiving Combination Chemotherapy (clinicaltrials.gov) - Dec 21, 2015
P2, N=1, Terminated, Sponsor: Case Comprehensive Cancer Center
Not yet recruiting --> Enrolling by invitation | Trial primary completion date: Mar 2015 --> Dec 2017 N=50 --> 1 | Recruiting --> Terminated | Trial primary completion date: Dec 2016 --> Dec 2015; Slow accrual
- dexamethasone injection / Generic mfg.
Enrollment closed, Surgery: DysDexVSSal: Dysphagia Following Anterior Cervical Spine Surgery; Steroid vs Saline (clinicaltrials.gov) - Dec 18, 2015
P=N/A, N=74, Active, not recruiting, Sponsor: West Virginia University
N=50 --> 1 | Recruiting --> Terminated | Trial primary completion date: Dec 2016 --> Dec 2015; Slow accrual Recruiting --> Active, not recruiting
- Enrollment change, Trial withdrawal, IO biomarker: Efficacy Study on the Transfer of Adenovirus With the CD40 Ligand Gene (AdcuCD40L) to Patients With Esophageal Carcinoma (clinicaltrials.gov) - Dec 17, 2015
P2, N=0, Withdrawn, Sponsor: Weill Medical College of Cornell University
Recruiting --> Active, not recruiting N=24 --> 0 | Terminated --> Withdrawn