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78 Mechanisms of Action

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|||||||||| Trial completion: Prenatal Test for Fetal Aneuploidy Detection (clinicaltrials.gov) - Jan 8, 2012
P=N/A, N=4000, Completed, Sponsor: Ariosa Diagnostics, Inc
Recruiting --> Completed

||||||||||  sertraline / Generic mfg.
Enrollment open:  Trial of Sertraline to Treat Children With Fragile X Syndrome (clinicaltrials.gov) -  Jan 4, 2012
P=N/A, N=72, Recruiting,  Sponsor: University of California, Davis
Recruiting --> Completed Not yet recruiting --> Recruiting

|||||||||| Trial completion: A New Prenatal Blood Test for Down Syndrome (clinicaltrials.gov) - Dec 19, 2011
P=N/A, N=4664, Completed, Sponsor: Women and Infants Hospital of Rhode Island
Not yet recruiting --> Recruiting Active, not recruiting --> Completed

|||||||||| New P1/2 trial, CAR T-Cell Therapy: CD19 CAR T Cells for B Cell Malignancies After Allogeneic Transplant (clinicaltrials.gov) - Nov 17, 2011
P1/2, N=30, Recruiting, Sponsor: Fred Hutchinson Cancer Research Center

|||||||||| Enrollment change: Beta Cell Function in Women With Turner Syndrome (clinicaltrials.gov) - Nov 6, 2011
P=N/A, N=25, Terminated, Sponsor: University of Aarhus
Active, not recruiting --> Completed N=12 --> 25

|||||||||| Trial completion: Growth Hormone Treatment of Women With Turner Syndrome (clinicaltrials.gov) - Nov 6, 2011
P=N/A, N=24, Completed, Sponsor: Britta E. Hjerrild
N=12 --> 25 Recruiting --> Completed

||||||||||  Bosulif (bosutinib) / Pfizer
Trial completion:  Bioequivalence And Food Effect Study Of Bosutinib In Healthy Subjects (clinicaltrials.gov) -  Nov 3, 2011
P1, N=88, Completed,  Sponsor: Pfizer
Recruiting --> Completed Active, not recruiting --> Completed

||||||||||  basimglurant (NOE-101) / Noema Pharma
Enrollment change:  A Study With RO4917523 in Patients With Fragile X Syndrome (clinicaltrials.gov) -  Oct 13, 2011
P2, N=40, Completed,  Sponsor: Hoffmann-La Roche
Active, not recruiting --> Completed N=32 --> 40

||||||||||  basimglurant (NOE-101) / Noema Pharma
Trial completion:  A Study With RO4917523 in Patients With Fragile X Syndrome (clinicaltrials.gov) -  Oct 13, 2011
P2, N=40, Completed,  Sponsor: Hoffmann-La Roche
N=32 --> 40 Active, not recruiting --> Completed

||||||||||  Zolinza (vorinostat) / Merck (MSD)
Trial completion:  Dasatinib and Vorinostat in Treating Patients With Accelerated Phase or Blastic Phase Chronic Myelogenous Leukemia or Acute Lymphoblastic Leukemia (clinicaltrials.gov) -  Oct 13, 2011
P1, N=5, Completed,  Sponsor: City of Hope Medical Center
Active, not recruiting --> Completed Active, not recruiting --> Completed

|||||||||| Trial completion: MELISSA: MatErnal BLood IS Source to Accurately Diagnose Fetal Aneuploidy (clinicaltrials.gov) - Oct 6, 2011
P=N/A, N=10000, Completed, Sponsor: Verinata Health, Inc.
Active, not recruiting --> Completed Recruiting --> Completed

|||||||||| Trial termination: Growth Factor Signature (GFS) Pilot Study (MK0000-098)(COMPLETED) (clinicaltrials.gov) - Oct 6, 2011
P1, N=9, Terminated, Sponsor: Merck Sharp & Dohme Corp.
Recruiting --> Completed Completed --> Terminated

|||||||||| Enrollment change: Growth Factor Signature (GFS) Pilot Study (MK0000-098)(COMPLETED) (clinicaltrials.gov) - Oct 6, 2011
P1, N=9, Terminated, Sponsor: Merck Sharp & Dohme Corp.
Completed --> Terminated N=50 --> 9

||||||||||  imatinib / Generic mfg., vincristine / Generic mfg.
Trial completion, Combination therapy:  AFR07: Imatinib Mesylate With Vincristine and Dexamethasone in Acute Lymphoblastic Leukemias With BCR-ABL Positive (clinicaltrials.gov) -  Oct 3, 2011
P2, N=55, Completed,  Sponsor: Assistance Publique - H
N=50 --> 9 Active, not recruiting --> Completed

||||||||||  Norditropin (somatropin) / Novo Nordisk
Trial completion:  Bioequivalence of Two Somatropin Products (Norditropin (clinicaltrials.gov) -  Oct 2, 2011
P1, N=30, Completed,  Sponsor: Novo Nordisk
Active, not recruiting --> Completed Active, not recruiting --> Completed

|||||||||| Enrollment closed: Method Comparison and Clinical Specificity Study: Evaluation of the Infinium HD Cytogenetic Abnormality Test (clinicaltrials.gov) - Sep 26, 2011
P=N/A, N=900, Active, not recruiting, Sponsor: Illumina, Inc.
Active, not recruiting --> Completed Recruiting --> Active, not recruiting

||||||||||  basmisanil (RG1662) / Roche
New P1 trial:  A Study of RG1662 in Individuals With Down Syndrome (clinicaltrials.gov) -  Sep 18, 2011
P1, N=35, Completed,  Sponsor: Hoffmann-La Roche

|||||||||| Preclinical: Metal Ions in Ceramic on Metal Total Hip Arthroplasty (clinicaltrials.gov) - Sep 15, 2011
P=N/A, N=83, Not yet recruiting, Sponsor: Hussain Kazi

||||||||||  equine conjugated estrogens / Generic mfg.
New P1 trial:  A Study To Compare The Amount Of Premarin Components That Is Absorbed Into The Blood Of Japanese Healthy Postmenopausal Women Following Oral Administration Of Two Different Tablets Of Premarin Under Fast and Fed Conditions. (clinicaltrials.gov) -  Sep 15, 2011
P1, N=72, Completed,  Sponsor: Pfizer

|||||||||| Trial completion: An Interactive Informed Consent and Education Program for Pregnant Women (clinicaltrials.gov) - Sep 13, 2011
P1, N=150, Completed, Sponsor: Northwestern University
Recruiting --> Active, not recruiting Active, not recruiting --> Completed

||||||||||  mavoglurant (AFQ056) / Novartis
New P2/3 trial:  Long-term, Safety and Tolerability Study of AFQ056 in Adolescent Patients With Fragile X Syndrome (Open-label) (clinicaltrials.gov) -  Sep 11, 2011
P2/3, N=170, Recruiting,  Sponsor: Novartis Pharmaceuticals

|||||||||| Enrollment change: Prenatal Test for Fetal Aneuploidy Detection (clinicaltrials.gov) - Sep 8, 2011
P=N/A, N=4000, Completed, Sponsor: Ariosa Diagnostics, Inc
Active, not recruiting --> Completed N=2000 --> 4000

|||||||||| Trial completion: Non-Invasive Screening for Fetal Aneuploidy (clinicaltrials.gov) - Sep 1, 2011
P=N/A, N=5000, Completed, Sponsor: Sequenom, Inc.
N=2000 --> 4000 Active, not recruiting --> Completed

|||||||||| New P2 trial, Post-transplantation: Cyclophosphamide for Prevention of Graft-Versus-Host Disease After Allogeneic Peripheral Blood Stem Cell Transplantation in Patients With Hematological Malignancies (clinicaltrials.gov) - Aug 31, 2011
P2, N=42, Active, not recruiting, Sponsor: Fred Hutchinson Cancer Research Center

||||||||||  Norditropin (somatropin) / Novo Nordisk
Enrollment change:  Observational Prospective Study on Patients Treated With Norditropin® (clinicaltrials.gov) -  Aug 23, 2011
P=N/A, N=17000, Enrolling by invitation,  Sponsor: Novo Nordisk
Active, not recruiting --> Completed N=10000 --> 17000

||||||||||  Bosulif (bosutinib) / Pfizer
Enrollment closed:  B1871006: Study Evaluating SKI-606 (Bosutinib) In Philadelphia Chromosome Positive Leukemias (clinicaltrials.gov) -  Aug 18, 2011
P1/2, N=571, Active, not recruiting,  Sponsor: Pfizer
N=10000 --> 17000 Recruiting --> Active, not recruiting

|||||||||| Biomarker, New P4 trial: EMR 200104_010: First Year Growth Response Associated Genetic Markers Validation Phase IV Open-label Study in Growth Hormone Deficient and Turner Syndrome Pre-pubertal Children: the PREDICT Pharmacogenetics Validation Study (clinicaltrials.gov) - Aug 16, 2011
P4, N=458, Completed, Sponsor: Merck KGaA

||||||||||  Zorbtive (somatropin) / EMD Serono
Trial completion:  Growth Hormone Treatment for the Prevention of Short Stature in Young Girls With Turner Syndrome Before the Age of 4 Years (clinicaltrials.gov) -  Aug 11, 2011
P4, N=64, Completed,  Sponsor: Merck KGaA
Recruiting --> Active, not recruiting Active, not recruiting --> Completed