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60 Companies |
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66 Products |
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66 Products |
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77 Mechanisms of Action |
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2 Trials |
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576 News |
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- | Enrollment change: Pilot Study of Startle-response Test to Assess Transcranial Direct Current Stimulation-induced Modulation of Hyperphagia in Prader-Willi Syndrome (clinicaltrials.gov) - Apr 26, 2019
P=N/A, N=31, Completed, Sponsor: University of Kansas Medical Center
N=52 --> 31
- | Trial completion: Morphee: Down Syndrome and Continuous Positive Pressure Therapy (clinicaltrials.gov) - Apr 21, 2019
P=N/A, N=31, Completed, Sponsor: Institut Jerome Lejeune
N=52 --> 31 Recruiting --> Completed
- |||| Preclinical, Trial termination: Does in Vivo Culture of Pre-cleavage Stage Embryo Reduce the Incidence of Aneuploidy? (clinicaltrials.gov) - Apr 4, 2019
P=N/A, N=35, Terminated, Sponsor: Anecova SA
Recruiting --> Completed Recruiting --> Terminated; Terminated due to difficult recruitment
- Enrollment change, Trial completion date, Trial termination: Aneuploidies in Embryos and Spermatozoa From Patients With Y-chromosome Microdeletions (clinicaltrials.gov) - Mar 8, 2019
P=N/A, N=5, Terminated, Sponsor: Instituto Valenciano de Infertilidad, IVI Alicante
Recruiting --> Terminated; Terminated due to difficult recruitment N=300 --> 5 | Trial completion date: Sep 2019 --> Jun 2018 | Recruiting --> Terminated; Insufficient recruitment
- | Trial completion, Trial completion date, Trial primary completion date: RCT/DD: DIR/ Floortime™ Parent Training Intervention for the Children With Developmental Disabilities (clinicaltrials.gov) - Mar 7, 2019
P=N/A, N=48, Completed, Sponsor: Kingkaew Pajareya
N=300 --> 5 | Trial completion date: Sep 2019 --> Jun 2018 | Recruiting --> Terminated; Insufficient recruitment Recruiting --> Completed | Trial completion date: Oct 2017 --> Dec 2016 | Trial primary completion date: Mar 2017 --> Dec 2016
- | lenalidomide / Generic mfg.
Trial completion, Trial completion date, Trial primary completion date, Monotherapy: The Efficacy and Safety of Lenalidomide Monotherapy in Red Blood Cell Transfusion Dependent Subjects With Myelodysplastic Syndrome (MDS) Associated With Del (5q) Abnormality (clinicaltrials.gov) - Feb 27, 2019
P2, N=36, Completed, Sponsor: King's College Hospital NHS Trust
Recruiting --> Completed | Trial completion date: Oct 2017 --> Dec 2016 | Trial primary completion date: Mar 2017 --> Dec 2016 Active, not recruiting --> Completed | Trial completion date: Dec 2015 --> May 2016 | Trial primary completion date: Dec 2015 --> May 2016
- | Trial completion, Enrollment change, Trial completion date, Trial primary completion date: Gait Parameters of Persons With Down Syndrome With and Without Orthotics Using GaitRite (clinicaltrials.gov) - Feb 16, 2019
P=N/A, N=23, Completed, Sponsor: Oregon Health and Science University
Active, not recruiting --> Completed | Trial completion date: Dec 2015 --> May 2016 | Trial primary completion date: Dec 2015 --> May 2016 Recruiting --> Completed | N=300 --> 23 | Trial completion date: Jun 2020 --> Aug 2018 | Trial primary completion date: Jun 2015 --> Aug 2018
- | Trial completion, Trial primary completion date: OT2SUITE: Follow-up of Prader Willi Syndrome Infants Treated by Oxytocin and Comparison With Not-treated Infants. (clinicaltrials.gov) - Jan 30, 2019
P=N/A, N=34, Completed, Sponsor: University Hospital, Toulouse
Recruiting --> Completed | N=300 --> 23 | Trial completion date: Jun 2020 --> Aug 2018 | Trial primary completion date: Jun 2015 --> Aug 2018 Recruiting --> Completed | Trial primary completion date: Dec 2018 --> May 2018
- | Trial completion, Trial completion date: Assessing the Feasibility of the Use of Visual Aids in Patient Education in Adults With Down Syndrome (DS) (clinicaltrials.gov) - Jan 23, 2019
P=N/A, N=40, Completed, Sponsor: Advocate Health Care
Recruiting --> Completed | Trial primary completion date: Dec 2018 --> May 2018 Active, not recruiting --> Completed | Trial completion date: Oct 2018 --> Oct 2017
- ||| Trial completion, Trial primary completion date: Evaluation of the Ease of Use, Preference, and Safety of EutropinPen Inj. (clinicaltrials.gov) - Jan 3, 2019
P4, N=116, Completed, Sponsor: LG Life Sciences
Active, not recruiting --> Completed | Trial completion date: Oct 2018 --> Oct 2017 Recruiting --> Completed | Trial primary completion date: Sep 2017 --> Dec 2017
- | Biomarker, Trial completion, Enrollment change, Trial completion date, Trial primary completion date: Correlative Biomarker Study in Patients With Myeloproliferative Disorders (clinicaltrials.gov) - Dec 13, 2018
P=N/A, N=592, Completed, Sponsor: Icahn School of Medicine at Mount Sinai
Recruiting --> Completed | Trial primary completion date: Sep 2017 --> Dec 2017 Recruiting --> Completed | N=860 --> 592 | Trial completion date: Jun 2019 --> Jul 2018 | Trial primary completion date: Jun 2019 --> Jul 2018
- | Trial completion: POPCORn: Primary Ovarian Insufficiency, Polycystic Ovary Syndrome & the CardiOvascular Risk Profile (clinicaltrials.gov) - Dec 11, 2018
P=N/A, N=125, Completed, Sponsor: UMC Utrecht
Recruiting --> Completed | N=860 --> 592 | Trial completion date: Jun 2019 --> Jul 2018 | Trial primary completion date: Jun 2019 --> Jul 2018 Recruiting --> Completed
- | Enrollment change, Trial termination: Evaluation of Autonomic Function in Individuals With Cornelia de Lange Syndrome (CdLS) (clinicaltrials.gov) - Dec 6, 2018
P=N/A, N=1, Terminated, Sponsor: Mayo Clinic
Recruiting --> Completed N=10 --> 1 | Recruiting --> Terminated; Difficulty in recruitment, Funding has run out.
- | Trial suspension: Single Center, Prospective Controlled Pilot Study of the OvaPrime Procedure (clinicaltrials.gov) - Nov 28, 2018
P=N/A, N=81, Suspended, Sponsor: OvaScience, Inc.
N=10 --> 1 | Recruiting --> Terminated; Difficulty in recruitment, Funding has run out. Active, not recruiting --> Suspended
- | lovastatin / Generic mfg., minocycline / Generic mfg.
Trial completion, Trial completion date: LovaMiX: Combined Treatment of Minocycline and Lovastatin to Treat Individuals With Fragile X Syndrome (clinicaltrials.gov) - Oct 15, 2018
P2, N=22, Completed, Sponsor: Université de Sherbrooke
Active, not recruiting --> Suspended Recruiting --> Completed | Trial completion date: Aug 2017 --> Nov 2017
- | Nebido (testosterone undecanoate depot injection) / Bayer
Trial completion date, Trial primary completion date: ALCeP: Androgen for Leydig Cell Proliferation (clinicaltrials.gov) - Sep 26, 2018
P2/3, N=56, Completed, Sponsor: University of Roma La Sapienza
Recruiting --> Completed | Trial completion date: Aug 2017 --> Nov 2017 Trial completion date: Oct 2014 --> Jun 2018 | Trial primary completion date: Aug 2013 --> Jun 2017
- | Preclinical, Trial completion date, Trial termination: In Vitro Follicle Activation (clinicaltrials.gov) - Aug 29, 2018
P=N/A, N=2, Terminated, Sponsor: National Foundation for Fertility Research
Trial completion date: Oct 2014 --> Jun 2018 | Trial primary completion date: Aug 2013 --> Jun 2017 Trial completion date: Jul 2018 --> Jul 2017 | Active, not recruiting --> Terminated; Results were not promising
- | Trial completion, Trial completion date: Philadelphia Chromosome Positive CML Patients Without Optimal Response or Tolerance to Bcr-Abl TKI (clinicaltrials.gov) - Aug 29, 2018
P1/2, N=85, Completed, Sponsor: Il-Yang Pharm. Co., Ltd.
Trial completion date: Jul 2018 --> Jul 2017 | Active, not recruiting --> Terminated; Results were not promising Active, not recruiting --> Completed | Trial completion date: Dec 2017 --> Jul 2018
- | Trial completion: Natural History of Amyloid Deposition in Adults With Down Syndrome (clinicaltrials.gov) - Aug 10, 2018
P=N/A, N=81, Completed, Sponsor: University of Pittsburgh
Active, not recruiting --> Completed | Trial completion date: Dec 2017 --> Jul 2018 Active, not recruiting --> Completed
- | Trial completion, Enrollment change: Obstructive Sleep Apnea and Down Syndrome: Clinical Examination Issue (clinicaltrials.gov) - Jul 30, 2018
P=N/A, N=17, Completed, Sponsor: Fondation Lenval
Active, not recruiting --> Completed Recruiting --> Completed | N=150 --> 17
- | Growtropin-II (somatropin biosimilar) - Dong / A
Trial completion: A Clinical Study to Assess the Efficacy and Safety of DA-3002 (clinicaltrials.gov) - Jul 27, 2018
P3, N=58, Completed, Sponsor: Dong-A ST Co., Ltd.
Recruiting --> Completed | N=150 --> 17 Active, not recruiting --> Completed
- | Enrollment change, Trial completion date, Trial termination, Trial primary completion date: Fertility Assessment in Patients With Klinefelter Syndrome (clinicaltrials.gov) - Jul 24, 2018
P=N/A, N=6, Terminated, Sponsor: University of Pittsburgh
Active, not recruiting --> Completed N=60 --> 6 | Trial completion date: Oct 2020 --> Dec 2017 | Recruiting --> Terminated | Trial primary completion date: Oct 2020 --> Dec 2017; Unable to recruit the anticipated number of subjects for this study
- | Trial completion, Trial primary completion date: Phenotypic Specific Communication Intervention for Children With Down Syndrome (clinicaltrials.gov) - Jul 12, 2018
P=N/A, N=78, Completed, Sponsor: Vanderbilt University
N=60 --> 6 | Trial completion date: Oct 2020 --> Dec 2017 | Recruiting --> Terminated | Trial primary completion date: Oct 2020 --> Dec 2017; Unable to recruit the anticipated number of subjects for this study Recruiting --> Completed | Trial primary completion date: Dec 2017 --> Aug 2017
- | Trial completion, Enrollment change: Parents as the Primary Sexuality Educators for Their Young Adults With Down Syndrome (clinicaltrials.gov) - Jun 18, 2018
P=N/A, N=13, Completed, Sponsor: Advocate Health Care
Recruiting --> Completed | Trial primary completion date: Dec 2017 --> Aug 2017 Active, not recruiting --> Completed | N=30 --> 13
- | Trial completion, Enrollment change, Trial completion date: Treatment of Sleep Disturbances in School-age Children With Down Syndrome (clinicaltrials.gov) - Jun 4, 2018
P=N/A, N=34, Completed, Sponsor: Children's Hospital Medical Center, Cincinnati
Active, not recruiting --> Completed | N=30 --> 13 Recruiting --> Completed | N=80 --> 34 | Trial completion date: Aug 2018 --> May 2018
- | Trial completion, Enrollment change, Trial completion date, Trial primary completion date, Metastases: Aneuploidy Rates in Advanced Maternal Age Patients Supplemented With Coenzyme Q10 (CoQ10) Versus Those That Are Not: a Pilot Study (clinicaltrials.gov) - May 4, 2018
P=N/A, N=21, Completed, Sponsor: Reproductive Endocrinology Associates of Charlotte
Recruiting --> Completed | N=80 --> 34 | Trial completion date: Aug 2018 --> May 2018 Recruiting --> Completed | N=30 --> 21 | Trial completion date: Aug 2016 --> May 2018 | Trial primary completion date: May 2016 --> May 2018
- | topiramate / Generic mfg.
Trial termination: TOPRADER: Study of the Efficacy of Topiramate in Patients With Prader Willi Syndrome Over 8 Weeks (clinicaltrials.gov) - Apr 11, 2018
P3, N=69, Terminated, Sponsor: Assistance Publique - Hôpitaux de Paris
Recruiting --> Completed | N=30 --> 21 | Trial completion date: Aug 2016 --> May 2018 | Trial primary completion date: May 2016 --> May 2018 Completed --> Terminated
- | Trial completion, Phase classification: Chinese Medicine(Hu Yang Yang Kun Formula) for Primary Ovarian Insufficiency (clinicaltrials.gov) - Apr 10, 2018
P1/2, N=48, Completed, Sponsor: Guangzhou University of Traditional Chinese Medicine
Completed --> Terminated Recruiting --> Completed | Phase classification: P1 --> P1/2
- | Zolinza (vorinostat) / Merck (MSD)
Trial completion: Phase I/II Study of Combination of Sorafenib, Vorinostat, and Bortezomib for the Treatment of Acute Myeloid Leukemia With Complex- or Poor-risk (Monosomy 5/7) Cytogenetics or FLT3-ITD Positive Genotype (clinicaltrials.gov) - Mar 31, 2018
P1/2, N=37, Completed, Sponsor: Hamid Sayar
Recruiting --> Completed | Phase classification: P1 --> P1/2 Recruiting --> Completed
- | Trial completion date: Assessing the Feasibility of the Use of Visual Aids in Patient Education in Adults With Down Syndrome (DS) (clinicaltrials.gov) - Mar 30, 2018
P=N/A, N=40, Active, not recruiting, Sponsor: Advocate Health Care
Recruiting --> Completed Trial completion date: Dec 2017 --> Oct 2018
- | Trial completion date: Parents as the Primary Sexuality Educators for Their Young Adults With Down Syndrome (clinicaltrials.gov) - Mar 3, 2018
P=N/A, N=30, Active, not recruiting, Sponsor: Advocate Health Care
Trial completion date: Dec 2017 --> Oct 2018 Trial completion date: Feb 2018 --> Mar 2018
- ||| Trial completion, Trial completion date, Trial primary completion date: Study of the Efficacy of New Non-invasive Prenatal Tests for Screening for Fetal Trisomies Using Maternal Blood (clinicaltrials.gov) - Feb 22, 2018
P=N/A, N=3819, Completed, Sponsor: CHU de Quebec-Universite Laval
Trial completion date: Feb 2018 --> Mar 2018 Active, not recruiting --> Completed | Trial primary completion date: Sep 2017 --> Jun 2017 | Trial completion date: Dec 2017 --> Jun 2017
- | Trial completion, Enrollment change, Trial completion date, Trial primary completion date: FaSchi22: Perception of Facial Emotions in Schizophrenia and 22q11 Deletion Syndrome (clinicaltrials.gov) - Feb 8, 2018
P=N/A, N=70, Completed, Sponsor: Hôpital le Vinatier
Active, not recruiting --> Completed | Trial primary completion date: Sep 2017 --> Jun 2017 | Trial completion date: Dec 2017 --> Jun 2017 Active, not recruiting --> Completed | N=120 --> 70 | Trial primary completion date: Oct 2018 --> Oct 2017 | Trial completion date: Nov 2018 --> Dec 2017
- prednisone / Generic mfg., dasatinib / Generic mfg., ibrutinib / Generic mfg.
Enrollment change, Trial withdrawal, Trial primary completion date: Study of Pts With Philadelphia Chromosome-Pos ALL With Comb of Ibrutinib, Dasatinib, and Prednisone (clinicaltrials.gov) - Jan 31, 2018
P1, N=0, Withdrawn, Sponsor: University of Utah
Active, not recruiting --> Completed | N=120 --> 70 | Trial primary completion date: Oct 2018 --> Oct 2017 | Trial completion date: Nov 2018 --> Dec 2017 N=24 --> 0 | Recruiting --> Withdrawn | Trial primary completion date: Aug 2021 --> Jan 2018
- | Metopirone (metyrapone) / HRA Pharma
Trial completion, Trial primary completion date: Diagnosis of Central Adrenal Insufficiency in Patients With Prader-Willi Syndrome (clinicaltrials.gov) - Jan 29, 2018
P=N/A, N=23, Completed, Sponsor: Nationwide Children's Hospital
N=24 --> 0 | Recruiting --> Withdrawn | Trial primary completion date: Aug 2021 --> Jan 2018 Recruiting --> Completed | Trial primary completion date: Dec 2015 --> Aug 2016
- || Enrollment closed: Single Center, Prospective Controlled Pilot Study of the OvaPrime Procedure (clinicaltrials.gov) - Jan 18, 2018
P=N/A, N=81, Active, not recruiting, Sponsor: OvaScience, Inc.
Recruiting --> Completed | Trial primary completion date: Dec 2015 --> Aug 2016 Recruiting --> Active, not recruiting
- | Trial completion, Enrollment change: ESHRE-ESTEEM: The Eshre Study Into The Evaluation of Oocyte Euploidy by Microarray Analysis (clinicaltrials.gov) - Jan 16, 2018
P=N/A, N=396, Completed, Sponsor: European Society of Human Reproduction and Embryology
Recruiting --> Active, not recruiting Recruiting --> Completed | N=600 --> 396
- | Enrollment closed: Parents as the Primary Sexuality Educators for Their Young Adults With Down Syndrome (clinicaltrials.gov) - Jan 10, 2018
P=N/A, N=30, Active, not recruiting, Sponsor: Advocate Health Care
Recruiting --> Completed | N=600 --> 396 Recruiting --> Active, not recruiting
- | Enrollment change, Trial withdrawal: Diagnostics for the Treatment of Progressive Mucosal Lesions of the Oral Cavity: a Prospective Study (clinicaltrials.gov) - Jan 9, 2018
P=N/A, N=0, Withdrawn, Sponsor: Maastricht University Medical Center
Recruiting --> Active, not recruiting N=374 --> 0 | Not yet recruiting --> Withdrawn
- | Trial completion, Trial primary completion date: Pilot Study of Startle-response Test to Assess Transcranial Direct Current Stimulation-induced Modulation of Hyperphagia in Prader-Willi Syndrome (clinicaltrials.gov) - Dec 28, 2017
P=N/A, N=52, Completed, Sponsor: University of Kansas Medical Center
N=374 --> 0 | Not yet recruiting --> Withdrawn Recruiting --> Completed | Trial primary completion date: Jul 2017 --> Oct 2016
- | gaboxadol (OV101) / Ovid Therapeutics, Angelini Group, Healx
Trial completion: Single Dose Pharmacokinetic (PK) Study (clinicaltrials.gov) - Nov 30, 2017
P1, N=12, Completed, Sponsor: Ovid Therapeutics Inc.
Recruiting --> Completed | Trial primary completion date: Jul 2017 --> Oct 2016 Active, not recruiting --> Completed
- || Enrollment change: Single Center, Prospective Controlled Pilot Study of the OvaPrime Procedure (clinicaltrials.gov) - Oct 27, 2017
P=N/A, N=95, Recruiting, Sponsor: OvaScience, Inc.
Active, not recruiting --> Completed N=50 --> 95
- imatinib / Generic mfg.
Trial primary completion date: ESPHALL: Safety and Efficacy of Imatinib Added to Chemotherapy in Treatment of Ph+ Acute Lymphoblastic Leukemia in Children (clinicaltrials.gov) - Oct 13, 2017
P2, N=49, Completed, Sponsor: Rennes University Hospital
N=50 --> 95 Trial primary completion date: Dec 2015 --> Mar 2016
- | Trial primary completion date: Treatment of Sleep Disturbances in School-age Children With Down Syndrome (clinicaltrials.gov) - Oct 5, 2017
P=N/A, N=80, Recruiting, Sponsor: Children's Hospital Medical Center, Cincinnati
Trial primary completion date: Dec 2015 --> Mar 2016 Trial primary completion date: Jun 2017 --> Jun 2018
- |||| Growtropin-II (somatropin biosimilar) - Dong / A
Trial primary completion date: A Clinical Study to Assess the Efficacy and Safety of DA-3002 (clinicaltrials.gov) - Sep 20, 2017
P3, N=58, Active, not recruiting, Sponsor: Dong-A ST Co., Ltd.
Trial primary completion date: Jun 2017 --> Jun 2018 Trial primary completion date: Jun 2016 --> May 2018
- gaboxadol (OV101) / Ovid Therapeutics, Angelini Group, Healx
Enrollment closed: Single Dose Pharmacokinetic (PK) Study (clinicaltrials.gov) - Sep 15, 2017
P1, N=12, Active, not recruiting, Sponsor: Ovid Therapeutics Inc.
Trial primary completion date: Jun 2016 --> May 2018 Recruiting --> Active, not recruiting
- ||| Enrollment open: Aneuploidies in Embryos and Spermatozoa From Patients With Y-chromosome Microdeletions (clinicaltrials.gov) - Sep 6, 2017
P=N/A, N=300, Recruiting, Sponsor: Instituto Valenciano de Infertilidad, IVI Alicante
Recruiting --> Active, not recruiting Active, not recruiting --> Recruiting
- | Trial completion, Trial primary completion date: Risk of Diabetes in Young Turner Syndrome Patients (clinicaltrials.gov) - Aug 23, 2017
P=N/A, N=120, Completed, Sponsor: Children's Hospital Medical Center, Cincinnati
Active, not recruiting --> Recruiting Recruiting --> Completed | Trial primary completion date: Dec 2015 --> Jun 2017
- | donepezil / Generic mfg.
Trial completion, Trial primary completion date: A Double-blind, Placebo-controlled Comparative Study and Open-label Extension Study to Confirm the Efficacy and Safety of E2020 in Subjects With Down Syndrome Having Regression Symptoms and Disabled Activities of Daily Living. (clinicaltrials.gov) - Aug 22, 2017
P2, N=36, Completed, Sponsor: Eisai Co., Ltd.
Recruiting --> Completed | Trial primary completion date: Dec 2015 --> Jun 2017 Active, not recruiting --> Completed | Trial primary completion date: Apr 2017 --> Sep 2016
- | Trial completion, Preclinical: DEPOSA: T21,18 and 13 Screening by Cell Free Fetal DNA in Low Risk Patients (clinicaltrials.gov) - Aug 15, 2017
P=N/A, N=933, Completed, Sponsor: Assistance Publique - Hôpitaux de Paris
Active, not recruiting --> Completed | Trial primary completion date: Apr 2017 --> Sep 2016 Active, not recruiting --> Completed