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Clinical, Journal: Absence of Distinct Immunohistochemical Distribution of Annexin A5, C3b, C4d, and C5b-9 in Placentas From Patients With Antiphospholipid Antibodies, Preeclampsia, and Systemic Lupus Erythematosus. (Pubmed Central) - Mar 2, 2020
Previously, antiphospholipid antibody (aPLA)-associated pregnancy complications have been thought to be a consequence of a unique aPLA-mediated pathogenic mechanism. However, the immunohistochemical similarity (increased complement and decreased AnxA5 staining) observed in placentas from patients with APLS, PEC, and SLE suggests that aPLA-associated pregnancy complications may reflect a more general autoimmune mechanism.
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Journal: Development of Teleost Intermuscular Bones Undergoing Intramembranous Ossification Based on Histological-Transcriptomic-Proteomic Data. (Pubmed Central) - Feb 15, 2020
Three proteins (collagen9α1, stat1, tnc) associated with chondrocytes did not exhibit significant changes through S2 to S4; however, proteins (entpd5, casq1a, pvalb, anxa2a, anxa5) which associated with osteoblasts and bone formation and differentiation showed significantly a higher expression level from S1 to S2, as well as to S3 and S4...The inhibitors of TGF-β and Wnt pathways were tested on zebrafish (sp7/eGFP) and the results indicated that both inhibitors significantly delayed IB development. This study provides a comprehensive understanding of the IB ossification pattern, which will help further elucidate the molecular mechanisms for IB development in teleosts.
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Journal, PD(L)-1 Biomarker, IO Biomarker: Annexin-V expression on CD4 T-cells with regulatory function. (Pubmed Central) - Feb 7, 2020
In vivo, using a model of delayed type hypersensitivity (DTH), murine CD4 ANXA5 T-cells inhibited Th1-responses. In conclusion, we report for the first time expression of ANXA5 on a subset of Treg that might bridge classical regulatory Treg function with immune.
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Biomarker, Journal: Interactions with muscle cells boost fusion, stemness and drug resistance of prostate cancer cells. (Pubmed Central) - Jan 27, 2020
In human prostate cancer tissues, expression of syncytin 1 and annexin A5, proteins that we found to be required for the cell fusion, positively correlated with the cancer development suggesting that these proteins can be used as biomarkers to evaluate cancer progression and potential therapeutic targets. Implications: The discovered effects of muscle cells on prostate cancer cells reveal a novel and specific pathway in which muscle cells in the microenvironment of prostate cancer cells promote cell fusion and cancer progression.
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Journal: Distinct prognostic values of Annexin family members expression in acute myeloid leukemia. (Pubmed Central) - Jan 8, 2020
Implications: The discovered effects of muscle cells on prostate cancer cells reveal a novel and specific pathway in which muscle cells in the microenvironment of prostate cancer cells promote cell fusion and cancer progression. Collectively, Annexin family members exert distinct prognostic roles in AML, and ANXA2 can be used as a biological marker for diagnosis and prognosis of pediatric AML.
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Journal: The relevance of ANXA5 genetic variants on male fertility. (Pubmed Central) - Dec 20, 2019
Athough the infertile patient groups had a higher prevalence of promoter variants, we could not demonstrate any biologically relevant effect of lower levels of annexin A5 on most male fertility parameters. A deficiency in an anticoagulation factor does not seem to impact male fertility.
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Journal: Charged giant unilamellar vesicles prepared by electroformation exhibit nanotubes and transbilayer lipid asymmetry. (Pubmed Central) - Nov 21, 2019
By quenching a fluorescent analog of the charged lipid, zeta potential measurements and experiments with the lipid marker annexin A5, we show that electroformed GUVs exhibit an asymmetric lipid distribution across the bilayer leaflets...The observed effects allow to control the molecular assembly of lipid bilayer leaflets. Vesicle tubulation as reported here is an example of protein-free reshaping of membranes and is caused by compositional lipid asymmetry between leaflets.
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CARRIERTEST GENNET - THE EXPANDED PRECONCEPTION CARRIER SCREENING () - Nov 13, 2019 - Abstract #OCC2019OCC_15;
CarrierTest can contribute to individualization and therefore more effective treatment of infertility and prevention of rare genetic disorders. There is a clinical option of preimplantation (PGT-M) or prenatal diagnostics or using compatible donor gametes for couples with significant risk of having affected offspring.
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Journal: A Novel Antigen-Sampling Cell in the Teleost Gill Epithelium With the Potential for Direct Antigen Presentation in Mucosal Tissue. (Pubmed Central) - Oct 29, 2019
The second phenotype exhibits similar characteristics to mammalian M cells; the corresponding cells bind the lectin UEA-1 but not WGA and show expression of M cell marker gene Anxa5...The present results suggest an unconventional antigen presentation mechanism in the primitive mucosal immune system of teleosts, which generally lack highly organized lymphoid tissues. Moreover, the results of this work may be valuable for the development of mucosal vaccines that specifically target M-type cells; mucosal vaccines significantly reduce working costs and the stress that is usually induced by vaccination via injection of individual fish.
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Journal: Annexin A5 involvement in bone overgrowth at the enthesis. (Pubmed Central) - Oct 27, 2019
AnxaA5 KD increased ALP expression in tenocytes and chondrocytes but not in osteoblasts, suggesting that increased ALP activity in the fibrocartilaginous tissue in AnxaA5 KO mice is directly caused by Anxa5 deletion in tenocytes or fibrocartilage cells. These data indicate that Anxa5 prevents bone overgrowth at the enthesis, whose formation is mediated through mechanical forces and modulating expression of mineralization regulators.
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Journal: Annexins induce curvature on free-edge membranes displaying distinct morphologies. (Pubmed Central) - Oct 24, 2019
ANXA4 and ANXA5 induce cooperative roll-up of the membrane starting from free edges, producing large rolls...A shared feature necessary for generating these morphologies is the ability to induce membrane curvature on free edged anionic membranes. Consequently, induction of membrane curvature may be a significant property of the annexin protein family that is important for their function.
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Journal: AnnexinA5-pHrodo: a new molecular probe for measuring efferocytosis. (Pubmed Central) - Oct 18, 2019
However, many of these are unable to differentiate between cells that have truly been phagocytosed and those still present on the surface of the macrophages hindering exact assessment of efferocytotic capacity. We herein describe AnxA5-pHrodo and its negative control M1234-pHrodo as new molecular probes to measure in vitro as well as ex-vivo efferocytotic capacity.
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Journal: The association between genetic polymorphisms of the interleukin-10, tumor necrosis factor-alpha, and annexin A5 gene loci and restenosis after percutaneous coronary angioplasty and stenting. (Pubmed Central) - Sep 17, 2019
After adjustment for clinical variables, the genetic polymorphisms at the IL-10, TNFα, and ANXA5 gene loci do not appear to be risk factors for >50% ISR in our population. However, our data suggested a significant association between diabetes mellitus, serum hs-CRP, stent type, and restenosis.
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Clinical, Journal: Genes Encoding Mammalian Oviductal Proteins Involved in Fertilization are Subjected to Gene Death and Positive Selection. (Pubmed Central) - Sep 11, 2019
...However, some genes were lost along the evolution of mammals and found as pseudogenes: annexin A5 (ANXA5) and deleted in malignant brain tumor 1 (DMBT1) in tarsier; oviductin (OVGP1) in megabat; and probably progestagen-associated endometrial protein (PAEP) in tarsier, mouse, rat, rabbit, dolphin, and megabat; prostaglandin D2 synthase (PTGDS) in microbat; and plasminogen (PLG) in megabat...These results strongly suggest that genes encoding oviductal proteins that are known to be important for gamete fertilization are subjected to positive selection during evolution, as numerous genes encoding proteins from mammalian seminal fluid. This suggests that such a rapid evolution may have as a consequence that two isolated populations become separate species more rapidly.
- |||||||||| doxorubicin hydrochloride / generics
Preclinical, Journal: Deciphering the molecular mechanism during doxorubicin-mediated oxidative stress, apoptosis through Nrf2 and PGC-1α in a rat testicular milieu. (Pubmed Central) - Sep 6, 2019
Apoptosis become found through DNA fragmentation assay and quantification of Caspase 3, Caspase 9, Bcl2 and Cytochrome C. Doxorubicin mediated oxidative stress and apoptosis in testicular milieu is through deregulation of Nrf2, PGC-1α, AHR, ARNT, PXR, SUMO-1, UCP2, UCP3, ANX A5, Caspase 3, Caspase 9, Bcl2, Cytochrome C, GR, and GPX. In end, doxorubicin-mediated oxidative stress and apoptosis is through diverse transcriptional factors and genes with respect to decreased antioxidant level, augmented ROS level and Annexin A5 in the testicular milieu.
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Journal: Exosomes from Human Placenta Purified by Affinity Chromatography on Sepharose Bearing Immobilized Antibodies Against CD81 Tetraspanin Contain Many Peptides and Small Proteins. (Pubmed Central) - Aug 17, 2019
Hence, screening for the M2/ANXA5 haplotype as a panel of laboratory investigations for RPL is recommended. ...SDS-PAGE and MALDI MS and MS/MS mass spectrometry of tryptic hydrolysates of proteins contained in these exosomes revealed eleven major proteins (>10 kDa): hemoglobin subunits, CD81, interleukin-1 receptor, annexin A5, cytoplasmic actin, alpha-actin-4, alkaline phosphatase, human serum albumin, serotransferrin, and lactotrasferrin...This finding can be useful for revealing biological functions of pure exosomes.
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Biomarker, Journal: Annexin A5 Protein as a Potential Biomarker for the Diagnosis of Asthma. (Pubmed Central) - Jul 19, 2019
...SDS-PAGE and MALDI MS and MS/MS mass spectrometry of tryptic hydrolysates of proteins contained in these exosomes revealed eleven major proteins (>10 kDa): hemoglobin subunits, CD81, interleukin-1 receptor, annexin A5, cytoplasmic actin, alpha-actin-4, alkaline phosphatase, human serum albumin, serotransferrin, and lactotrasferrin...This finding can be useful for revealing biological functions of pure exosomes. Our results imply that ANXA5 plays a potential role in asthma pathogenesis and may be a promising marker for exacerbated bronchial asthma and exposure to air pollutants.
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Clinical, Journal: Impact of ANXA5 polymorphisms on glioma risk and patient prognosis. (Pubmed Central) - Jun 23, 2019
Due to its immunomodulatory roles in B-Ly homeostasis, supplementation with VD3 should be considered in APS, at least in subgroup with severe form of the disease, i.e., VAPS. This study firstly provided evidence for the impact of ANXA5 polymorphism on the susceptibility and prognosis of glioma, suggesting ANXA5 variants might have potential roles in the etiology of glioma.
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Journal, IO Biomarker: Anti-CD73 and Anti-OX40 immunotherapy coupled with a novel biocompatible enzyme prodrug system for the treatment of recurrent, metastatic ovarian cancer. (Pubmed Central) - Jun 15, 2019
...In order to provide an alternative a novel fusion protein, mCTH-ANXA5, has been developed for the treatment of recurrent, metastatic ovarian cancer...Further evaluation of the combination therapy revealed a strong antibody-mediated immune response, and an increased infiltration of cytotoxic T-cells along with a decrease in tumor promoting immune cells. This study demonstrates the efficacy of a synergistic, multi-drug system by attacking the tumor as well as enlisting the body's own defense system to treat the patient.
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Biomarker, Journal: Expression profile and distribution of Annexin A1, A2 and A5 in human semen. (Pubmed Central) - May 30, 2019
Results showed that ANXA1 and A2 expressions appear to be related with DNA fragmentation suggesting their possible use as new biomarkers for sperm DNA quality. ANXA5's natural presence in spermatozoa suggest that revision of high-quality sperm selection by binding to this protein is needed.
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Journal: AnnexinA5 promote glioma cell invasion and migration via the PI3K/Akt/NF-κB signaling pathway. (Pubmed Central) - Apr 9, 2019
Importantly, mechanistic studies further reveal that AnnexinA5 is an essential transcriptional target of Snail via activating the PI3K/Akt/NF-κB signaling pathway. Taken together, these findings suggest that AnnexinA5 or the PI3K/Akt/NF-κB pathway may be promising therapeutic molecules to eradicate glioma metastases.
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Preclinical, Journal: Proteomic characterization of early lung response to breast cancer metastasis in mice. (Pubmed Central) - Apr 7, 2019
The analysis enabled revealing the importance of calcium signaling during the early phase of metastasis development, early cytoskeleton and extracellular matrix reorganization, activation of defense mechanisms and metabolic adaptations. It seems that the tissue response is an interplay between pro- and anti-metastatic mechanisms accompanied by inflammation, oxidative stress and dysfunction of the barrier endothelial cells.
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Journal: Protein expression in submandibular glands of young rats is modified by a high-fat/high-sugar maternal diet. (Pubmed Central) - Mar 29, 2019
These findings provide the first evidence in intestinal protein alterations of IUGR neonates in response to colostrum ingestion, and thus render new insights into the mechanisms responsible for impaired growth in IUGR neonates and into new nutritional intervention strategies. A maternal Western diet modifies the protein composition of the offspring's salivary glands, which may have consequences on the salivary function.
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