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  • ||||||||||  janthinobacterium lividum (DBI-001) / DermBiont
    Journal:  Priority effects alter microbiome composition and increase abundance of probiotic taxa in treefrog tadpoles. (Pubmed Central) -  May 17, 2024   
    Second, we experimentally inoculated embryos to determine if priority effects (i) could be used to increase the relative abundance of Janthinobacterium lividum, an amphibian-associated bacteria capable of preventing fungal infection, and (ii) would lead to observed differences in the relative abundances of two closely related bacteria from the genus Pseudomonas...Further, we provide support for the use of bacterial priority effects as a mechanism to increase the relative abundance of target probiotic taxa in a developing host. While our results show that priority effects are not universally effective across all host-associated bacteria, our ability to increase the relative abundance of specific probiotic taxa may enhance conservation strategies that rely on captive rearing of endangered vertebrates.
  • ||||||||||  SM-020 / DermBiont
    Enrollment open, Trial primary completion date:  A Trial to Evaluate the Safety and Efficacy of SM-020 Gel 1.0% in Subjects With Seborrheic Keratosis (clinicaltrials.gov) -  May 10, 2024   
    P2,  N=60, Recruiting, 
    While our results show that priority effects are not universally effective across all host-associated bacteria, our ability to increase the relative abundance of specific probiotic taxa may enhance conservation strategies that rely on captive rearing of endangered vertebrates. Active, not recruiting --> Recruiting | Trial primary completion date: Jun 2024 --> Sep 2024
  • ||||||||||  janthinobacterium lividum (DBI-001) / DermBiont
    Journal:  Improvement of violacein production using abiotic stresses and microbial adaptation. (Pubmed Central) -  Apr 1, 2024   
    The aim of the current research was to improve violacein production with Janthinobacterium lividum using abiotic stresses and bacterial adaptation against stress...Then, the production of violacein under hydrogen peroxide (H2O2) and ampicillin (Amp) stresses and acyl homoserine lactone (AHL) was evaluated...Also, the expression of vioA increased in the presence of Amp but H2O2 had no significant effect on vioA expression. Totally, we showed that microbial adaptation and abiotic stresses are cost-effective methods to generate significant improvement in violacein production.
  • ||||||||||  janthinobacterium lividum (DBI-001) / DermBiont
    Journal:  Together or Alone: Evaluating the Pathogen Inhibition Potential of Bacterial Cocktails against an Amphibian Pathogen. (Pubmed Central) -  Feb 1, 2023   
    Several experimental trials have tested the use of Janthinobacterium lividum to reduce mortality due to Bd infections, usually in single-strain amendments...For Colorado boreal toads, we addressed whether there are other bacterial strains that also inhibit Bd (potentially better than does J. lividum) and whether we can create two-strain probiotics that function better than do single-strain probiotics. In addition, we evaluate which types of interactions occur between two-strain combinations and what these results mean in the context of adding a probiotic to an existing amphibian skin microbiome.
  • ||||||||||  janthinobacterium lividum (DBI-001) / DermBiont
    Enrollment change, Trial termination:  Study the Safety and Efficacy of DBI-001 Gel Versus Aqueous Gel (clinicaltrials.gov) -  Oct 12, 2022   
    P2,  N=10, Terminated, 
    This study will help expand our understanding of microbial interactions and determine one of the causes in the development of diseases and death in Baikal sponges. N=20 --> 10 | Suspended --> Terminated; Sponsor suspension and not due to safety or site-related matters.
  • ||||||||||  janthinobacterium lividum (DBI-001) / DermBiont
    Review, Journal:  Violacein and its antifungal activity: comments and potentialities. (Pubmed Central) -  Sep 24, 2022   
    It presents a significant range of effects against phytopathogenic and human fungi, besides being featured as having low toxicity, and by its important ecological role in protecting amphibian species and applications in dyed medical fabric. The hypothesis about violacein's action mechanisms against mucormycosis (Rhizopus arrhizus) and candidiasis (Candida auris) is herein discussed based on data available in the scientific literature.
  • ||||||||||  janthinobacterium lividum (DBI-001) / DermBiont
    Journal:  Alhagi maurorum extract modulates quorum sensing genes and biofilm formation in Proteus mirabilis. (Pubmed Central) -  Aug 22, 2022   
    The AME's effect on adhesion and quorum sensing (QS) were investigated by in vitro adhesion assay on cell culture and agar overlay assay using Janthinobacterium lividum (ATCC 12472) as a biosensor strain...This study showed that AME as a natural compound reduced biofilm formation of P. mirabilis by targeting virulence factor genes, quorum sensing, and other strategies that include preventing the adhesion of P. mirabilis to the cells. The results suggest that A. maurorum extract might have the potential to be considered for preventing UTIs caused by P. mirabilis.
  • ||||||||||  janthinobacterium lividum (DBI-001) / DermBiont
    Trial primary completion date:  Study the Safety and Efficacy of DBI-001 Gel Versus Aqueous Gel (clinicaltrials.gov) -  Jul 1, 2022   
    P2,  N=20, Recruiting, 
    This baseline information can also help the administrative officials to take necessary steps for its conservation and management. Trial primary completion date: Jun 2022 --> Oct 2022
  • ||||||||||  janthinobacterium lividum (DBI-001) / DermBiont
    Trial primary completion date:  Study the Safety and Efficacy of DBI-001 Gel Versus Aqueous Gel (clinicaltrials.gov) -  Apr 14, 2022   
    P2,  N=20, Recruiting, 
    Trial primary completion date: Jun 2022 --> Oct 2022 Trial primary completion date: Mar 2022 --> Jun 2022
  • ||||||||||  janthinobacterium lividum (DBI-001) / DermBiont
    Clinical, Journal:  Effectiveness of antifungal treatments during chytridiomycosis epizootics in populations of an endangered frog. (Pubmed Central) -  Jan 18, 2022   
    Collectively, these results indicate that our mitigation efforts were ineffective in causing long-term changes in frog-Bd dynamics and increasing population persistence, due largely to the inability of early life stages to mount an effective immune response against Bd. This results in repeated recruitment failure and a low probability of population persistence in the face of ongoing Bd infection.
  • ||||||||||  janthinobacterium lividum (DBI-001) / DermBiont
    Journal:  Molecular signatures of Janthinobacterium lividum from Trinidad support high potential for crude oil metabolism. (Pubmed Central) -  Jan 14, 2022   
    The findings showed that the primary sequence of VioAp and EstA/Bp were unique to the Trinidad strains and these molecular signatures were reflected in phylogenetic inference. Our results supported chemotaxis, possible elective inactivation of VioA gene expression and secreted lipase activity as survival mechanisms of the Trinidad strains in petrogenic conditions.
  • ||||||||||  janthinobacterium lividum (DBI-001) / DermBiont
    Journal:  First Complete Genome Sequences of Janthinobacterium lividum EIF1 and EIF2 and their Comparative Genome Analysis. (Pubmed Central) -  Sep 10, 2021   
    The chromosome encodes 5,691 coding sequences, 122 rRNAs, 93 tRNAs, and 1 tm-RNA and the plasmid harbors 245 coding sequences. In addition to the highly conserved chromosomally encoded violacein operon, the plasmid comprises a non-ribosomal peptide synthetase cluster (NRPS) with similarity to xenoamicin, which is a bioactive compound effective against protozoan parasites.
  • ||||||||||  janthinobacterium lividum (DBI-001) / DermBiont
    Enrollment change, Trial completion date, Trial termination:  A Trial of Safety/Efficacy of Test Article in Patients With Interdigital T. Pedis (clinicaltrials.gov) -  Jun 18, 2021   
    P2,  N=39, Terminated, 
    Trial completion date: Feb 2021 --> Jun 2020 | Suspended --> Terminated; Covid-19 has shut the clinic indefinitely N=80 --> 39 | Trial completion date: Feb 2021 --> Jun 2020 | Suspended --> Terminated; Covid- 19 has shut the clinic
  • ||||||||||  janthinobacterium lividum (DBI-001) / DermBiont
    [VIRTUAL] Together Or Alone: Amphibian Probiotic Microbes Are More Successful Against A Skin Pathogen In Cocktails Of Related Strains () -  May 31, 2021 - Abstract #WMF2021WMF_4987;    
    Many conservation researchers are employing innate amphibian skin bacteria that inhibit Bd in culture as skin probiotics, the most heavily favored of these being Janthinobacterium lividum strains...Psuedomonas, Microbacterium, and Chryseobacterium were more inhibitive than these strains but had decreased inhibition when combined with Burkholdariales microbes. This suggests two things: (1) Burkholdariales microbes, which includes the oft-favored J. lividum strains, can be more effective Bd-inhibitors in cocktails of different strains of the same species, and (2) other, less phylogenetically-related but still inhibitive, strains that live on toad skin may lose their inhibitive abilities if a Burkholdariales strain is applied, and therefore the context of the starting community may be a significant factor for future consideration and study of probiotic applications to amphibian skin.
  • ||||||||||  janthinobacterium lividum (DBI-001) / DermBiont
    Trial completion date:  Observer-Blinded Dose Escalating, Single Dose to Study Safety and Antimicrobial Efficacy of Gel vs. Placebo (clinicaltrials.gov) -  Feb 3, 2021   
    P2,  N=12, Suspended, 
    These species were likely involved in controlling pests, such as infectious nematodes and fungi, decomposing root debris, and helping turfgrass water and nutrient uptake; yet these possibilities need to be further examined. Trial completion date: Oct 2020 --> Feb 2021
  • ||||||||||  janthinobacterium lividum (DBI-001) / DermBiont
    Journal:  Successional trajectory of bacterial communities in soil are shaped by plant-driven changes during secondary succession. (Pubmed Central) -  Dec 16, 2020   
    Janthinobacterium lividum, Candidatus Xiphinematobacter and Rhodoplanes were indicator species of different growth stages of alder...We also found positive association of alder with late-successional Quercus leucotrichophora (Oak). Together, the changes in soil bacterial community shaped by early-coloniser alder and its positive association with late-successional oak suggests a crucial role played by alder in ecosystem recovery of degraded habitats.
  • ||||||||||  janthinobacterium lividum (DBI-001) / DermBiont
    Journal:  Probiotics Modulate a Novel Amphibian Skin Defense Peptide That Is Antifungal and Facilitates Growth of Antifungal Bacteria. (Pubmed Central) -  May 28, 2020   
    Brevinin-1Ma was tested against a range of amphibian skin cultures and found to inhibit growth of fungal pathogens Bd and B. salamandrivorans, but enhanced the growth of probiotic bacteria including Janthinobacterium lividum, Chryseobacterium ureilyticum, Serratia grimesii, and Pseudomonas sp...Thus, skin exposure to probiotic bacterial cultures induced a shift in skin defense peptide profiles that appeared to act as an immune response functioning to regulate the microbiome. In addition to direct microbial antagonism, probiotic-host interactions may be a critical mechanism affecting disease resistance.