- |||||||||| Remofuscin (soraprazan) / Katairo
10-year evolution of the number of surgeries for female urinary incontinence in France (2015-2024) (Red Area, Room 14) - Jan 7, 2026 - Abstract #EAU2026EAU_599;
The use of bulking agents rose by 359.9%...These shifts likely reflect regulatory tightening, centralization to higher-volume teams, and changing patient preferences amid mesh scrutiny rather than a reduced disease burden. Future policy and service organization should therefore focus on ensuring timely access to effective surgery, maintaining training in non-mesh techniques, and providing balanced counseling.
- |||||||||| Remofuscin (soraprazan) / Katairo
Journal: Neuromuscular Electrostimulation of the Common Peroneal Nerve Increases Microvascular Flux in the Wound bed of Diabetic Foot Ulcers. (Pubmed Central) - Aug 29, 2025
Pulsatility in the wound bed increased by 183% (95%CI 61%-517%, P?=?.005), while pulsatility in the peri-wound increases by 359% (95%CI 264%-455%, P?=?.001). Additionally, an increase in flux and pulsatility was observed in the neuroischemic ulcers.ConclusionsNeuromuscular stimulation of the common peroneal nerve presents a mode of activating the leg muscle pump without additional pressure insult to the foot and has potential to support the microcirculation during wound-healing, effectively emulating exercise without any of the attendant risks of exercise to the neuropathic or neuroischemic foot.
- |||||||||| Review, Journal: Stargardt's Disease: Molecular Pathogenesis and Current Therapeutic Landscape. (Pubmed Central) - Aug 2, 2025
Gene therapy trials explore ABCA4 supplementation including strategies like RNA exon editing (ACDN-01) and bioengineered ambient light-activated OPSIN...Trials like DRAGON (Phase 3, tinlarebant), STARLIGHT (phase 2, bioengineered OPSIN) show promise, but optimizing efficacy remains challenging. With the key problem of establishing genotype-phenotype correlations, the future of STGD1 therapy may rely on approaches targeting oxidative stress, lipid metabolism, inflammation, complement regulation, and genetic repair.
- |||||||||| Remofuscin (soraprazan) / Katairo
Journal: Assessing the Functional and Structural Properties of Peanut Meals Modified by Transglutaminase-Coupled Glycation. (Pubmed Central) - Jun 13, 2025
Additionally, superior emulsification, foaming, and oil-absorbing properties were achieved for the modified PM, which were named EPM, FPM, and OPM, respectively (specimens under different modification conditions). Notably, the emulsification activity of the EPM sample was enhanced by 69.8% (i.e., from 18.48 to 31.38 m2/g); the foaming capacity of the FPM specimen was increased by 84.00% (i.e., from 21.00 to 46.00%); and the oil-absorbing capacity of the OPM sample was enhanced by 359.57% (i.e., from 1.41 to 6.48 g/g protein).
- |||||||||| Remofuscin (soraprazan) / Katairo
Journal: Understanding Risk Factors for Physical Assault in a Large Inpatient Behavioral Health System. (Pubmed Central) - May 21, 2025
A total of 15,186 unique inpatients were evaluated, and 556 physical assaults committed by 359 (2.4%) patients during the study period were identified...This study represents one of the largest investigations into rates of assault by patients in U.S. inpatient psychiatric hospitals. By attaining a greater understanding of risk factors for inpatient assault, this study may contribute to the development of risk assessment and management methodologies.
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Journal: AMF and biochar reshape the bacterial network in rhizosphere soil of Ricinus communis under chromium (Cr) stress and improve soil quality. (Pubmed Central) - May 14, 2025
Results indicated that under 150?mg/kg Cr stress, the AMF-biochar combination significantly increased castor plant fresh weight and soil quality index by 359.70?% and 121.25?%, respectively, compared to treatments without biochar or AMF (P?<?0.05)...Network analysis and community assembly results revealed that AMF and biochar together significantly enhanced soil bacterial network complexity and average niche width. In conclusion, the AMF-biochar combination effectively promoted Ricinus communis growth under Cr stress and regulated rhizosphere soil bacterial community stability and assembly processes, providing valuable insights into plant-microbe interactions under Cr(VI) stress.
- |||||||||| Remofuscin (soraprazan) / Katairo
Journal: Interrupted time series analysis of the impact of COVID-19 on emergency and elective surgeries in Iranian hospitals. (Pubmed Central) - Apr 11, 2025
Due to the pandemic there was a significant decrease by 359.6; however, we observed a gradual recovery in surgical activity with an average increase of 15.8 surgeries above the pre-pandemic levels...The COVID-19 pandemic significantly impacted surgical services in Iranian hospitals, causing a reallocation of resources to COVID-19 care and postponement of non-urgent surgeries. There is a need for strategic planning and policy interventions to ensure continuity of surgical care during health emergencies.
- |||||||||| Remofuscin (soraprazan) / Katairo
Journal: Molecular dynamics method to predict the effects of temperature and strain rate on mechanical properties of Aluminum/Copper superalloy. (Pubmed Central) - Mar 17, 2025
The results show a significant enhancement in both UTS and elastic modulus with increasing copper content, with the UTS increasing by 359% and the elastic modulus by 281% when copper content rises from 1 to 20%...Additionally, higher strain rates were found to improve both UTS and elastic modulus, with an 11.95% increase in UTS and an 8.34% increase in elastic modulus at the highest strain rate (0.01 ps-1). These findings demonstrate the critical role of alloy composition, temperature, and strain rate in tailoring the mechanical properties of Al-Cu alloys, providing insights for optimizing the material for high-performance applications.
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Journal: Wearable devices for out-of-hospital cardiac arrest: A population survey on the willingness to adhere. (Pubmed Central) - Aug 28, 2024
The survey was completed by 359 participants...Individuals were willing to continuously wear wearable devices for OHCA detection, especially at increased hypothetical risk of OHCA. Optimizing willingness is not just a matter of adjusting for user preferences, but also increasing perception of urgency through awareness and education about OHCA.
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Journal: Enzymatic Synthesis of Indole-Based Imidazopyridine using ?-Amylase. (Pubmed Central) - Mar 18, 2024
The imidazo[1,2-a]pyridine scaffold has gained significant attention due to its presence as a lead structure in several commercially available pharmaceuticals like zolimidine, zolpidem, olprinone, soraprazan, etc. Further, indole-based imidazo[1,2-a]pyridine derivatives have been found interesting due to their anticancer and antibacterial activities...The generality and robustness of this protocol were shown by synthesizing differently substituted indole-based imidazo[1,2-a]pyridines in good isolated yields. Furthermore, to make ?-amylase a reusable catalyst for GBB multicomponent reaction, it was immobilized onto magnetic metal-organic framework (MOF) materials [Fe3O4@MIL-100(Fe)] and found reusable up to four consecutive catalytic cycles without the significant loss in catalytic activity.
- |||||||||| Remofuscin (soraprazan) / Katairo
Review, Journal: Microplastic in mangroves: A worldwide review of contamination in biotic and abiotic matrices. (Pubmed Central) - Sep 23, 2023
We analyzed 53 articles on MPs in Asia, America, and Africa and produced by 359 authors, although very localized, lacking wide-scale coverage of mangrove coasts around the world...Therefore, for future research, it is relevant to enhance spatial and temporal sampling of MP contamination and to establish standardized protocols to enable effective comparisons between mangrove areas, rivers, beaches, and coastal seas. In addition, it is crucial to investigate the role of MPs as carriers or vectors of other pollutants.
- |||||||||| Remofuscin (soraprazan) / Katairo
Observational data, Journal: What factors contribute towards ambulance on-scene times for suspected stroke patients? An observational study. (Pubmed Central) - May 30, 2023
About 2037 suspected stroke patients were conveyed between July and December 2021, resulting in 581 fully completed surveys by 359 different clinicians...This type of data can be used to target interventions at behaviours that extend pre-hospital OST but which have questionable patient benefit. This approach will be evaluated in a follow up study in the North East of England.
- |||||||||| Remofuscin (soraprazan) / Katairo
Journal: The company Christmas party and employee happiness. (Pubmed Central) - Jan 8, 2023
Data were provided by 359 employees from various organizations in Germany, who completed an online survey at the beginning of January 2019...Furthermore, employee age, organizational identification, involvement in planning, a human relations and an internal process culture, a speech, providing both alcoholic and non-alcoholic beverages, heavy drinking, supervisor and coworker inappropriate behavior, formality, and symbolism were differentially associated with high- and low-arousal positive and negative affect. These findings suggest several directions for future research on company parties and have practical implications for organizations and party planning committees.
- |||||||||| Remofuscin (soraprazan) / Katairo
Retrospective data, Journal: Terror-related injuries in Somalia: a retrospective cohort of 2426 hospitalized cases along 7 years. (Pubmed Central) - Oct 22, 2022
A total of 2426 patients were injured by 359 explosions and firearm attacks during the study period...The inpatient mortality rate was 11.6%. The findings of the study revealed that suicide bombings explosions are associated with multiple body site injuries, a greater rate of severe and critical internal injuries, and a higher mortality rate.
- |||||||||| Remofuscin (soraprazan) / Katairo
Journal: HIV-related stigma and discrimination by healthcare workers in Egypt. (Pubmed Central) - Jul 10, 2022
Provision of infection control supplies to protect against occupational exposure is also needed. The setting and enforcement of anti-stigma policies and guidelines in various healthcare settings are crucial.
- |||||||||| Journal: Structural Basis for Binding of Potassium-Competitive Acid Blockers to the Gastric Proton Pump. (Pubmed Central) - Jun 11, 2022
We reveal that revaprazan has a novel binding mode in which its tetrahydroisoquinoline moiety binds deep in the cation transport conduit. The mechanism of action of these P-CABs can now be evaluated at the molecular level, which will facilitate the rational development and improvement of currently available P-CABs to provide better treatment of acid-related gastrointestinal diseases.
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Journal: Treatment guideline concordance, initiation, and abandonment in patients with non-metastatic breast cancer from the African Breast Cancer-Disparities in Outcomes (ABC-DO) cohort in sub-Saharan Africa: a prospective cohort study. (Pubmed Central) - Jun 8, 2022
The mechanism of action of these P-CABs can now be evaluated at the molecular level, which will facilitate the rational development and improvement of currently available P-CABs to provide better treatment of acid-related gastrointestinal diseases. A high proportion of patients with non-metastatic breast cancer did not initiate, did not fully complete, or abandoned treatment with surgery, systemic therapy, radiotherapy, or an appropriate combination of these, highlighting the need for improved treatment access and completion in sub-Saharan Africa to potentially prevent premature breast cancer deaths.
- |||||||||| Remofuscin (soraprazan) / Katairo
Intraoperative adverse event reporting in urology: Global ICARUS survey results (Green Area, Room 1) - May 23, 2022 - Abstract #EAU2022EAU_2834;
Availability of classification systems and society guidelines are endorsed as the most likely to improve iAE reporting. Infrequent and inconsistent iAE reporting may be attributed to lack of awareness of current resources.
- |||||||||| Remofuscin (soraprazan) / Katairo
Journal: Remofuscin induces xenobiotic detoxification via a lysosome-to-nucleus signaling pathway to extend the Caenorhabditis elegans lifespan. (Pubmed Central) - May 6, 2022
Moreover, remofuscin failed to extend the lives of C. elegans with loss-of-function mutations (lipl-1, lbp-8, nhr-234, nhr-49, nhr-8, cyp-35A1, cyp-35A2, cyp-35A3, cyp-35A5, and gst-5), suggesting that these genes are associated with lifespan extension in remofuscin-treated C. elegans. In conclusion, remofuscin activates the lysosome-to-nucleus pathway in C. elegans, thereby increasing the expression levels of xenobiotic detoxification genes resulted in extending their lifespan.
- |||||||||| bleomycin / Generic mfg.
Preclinical, Journal: Protective effects of heterophyllin B against bleomycin-induced pulmonary fibrosis in mice via AMPK activation. (Pubmed Central) - Apr 8, 2022
Furthermore, co-administration of heterophyllin B with AMPK inhibitor dorsomorphin (Compound C) significantly blocked the improvement effects of heterophyllin B on BLM-damaged lung tissue, and also increased the protein expression of STING which was inhibited by heterophyllin B in fibrotic lungs (P < 0.001)...In the present study we found that, in vitro, heterophyllin B significantly inhibited alveolar epithelial mesenchymal transition (EMT) and lung fibroblast transdifferentiation. We also found that the inhibition of heterophyllin B on lung fibroblast transdifferentiation and STING expression was reversed by Compound C. To summarize, heterophyllin B exhibited protective effects on BLM-induced lung fibrosis potentially by inhibiting TGF-Smad2/3 signalings and AMPK-mediated STING signalings.
- |||||||||| Remofuscin (soraprazan) / Katairo
Journal: Nasal irrigation practice habits in infants: A Belgian survey: Nasal irrigation practice habits in infants. (Pubmed Central) - Apr 5, 2022
These data suggest a possible therapeutic approach to untreatable lipofuscin-mediated diseases like AMD, SD and lipofuscinopathies in neurodegenerative diseases. Although some common NIPH viewpoints among the surveyed participants were identified, several disagreements were reported, reflecting the absence of a standardized method of nasal irrigation.
- |||||||||| Remofuscin (soraprazan) / Katairo
Journal: Enhanced adsorption performance of alginate/MXene/CoFeO for antibiotic and heavy metal under rotating magnetic field. (Pubmed Central) - Oct 6, 2021
The isotherm fitting chose Cu and CIP as the model pollutants, the isotherm fitting shows that the adsorption capacity of CIP is significantly improved by 24.2%.The magnetic effect of the adsorption capacity of Cu is not obvious, which indicated the selectivity for adsorption; however, the adsorption rates of CIP and Cu are greatly improved by 359.76% and 371% respectively...The combination of the external magnetic field and the inherent magnetic properties of the adsorbent can adjust the adsorption process and the selectivity of pollutants. It also provides an innovative and practical method for MF to remediate contaminants in the magnetically enhanced adsorption system.
- |||||||||| Remofuscin (soraprazan) / Katairo
Journal: Analyzing Twitter as a Platform for Alzheimer-Related Dementia Awareness: Thematic Analyses of Tweets. (Pubmed Central) - Sep 15, 2019
Themes from the content of tweets highlight the mixture of the political climate and the supportive network present on Twitter. The ability to use Twitter to combat stigma and raise awareness of mental health indicates the benefits that can potentially be facilitated via the platform, but negative stigmatizing tweets may interfere with the effectiveness of this social support.
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