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Preclinical, Journal, Immunomodulating: Mucosal IFN?1 mRNA-based immunomodulation effectively reduces SARS-CoV-2 induced mortality in mice. (Pubmed Central) - Sep 10, 2024
Here, we investigate the activity of lipidoid nanoparticle (LNP)-formulated mRNA encoding human IFN?1 (ETH47), which is a critical driver of innate immunity at mucosal surfaces protecting from viral infections...These data support the development of inhaled administration of IFN?1 mRNA as a potential prophylactic option for individuals exposed to SARS-CoV-2 or at risk suffering from COVID-19. Based on the broad antiviral activity of IFN?1 regardless of virus or variant, this approach might also be utilized for other respiratory viral infections or pandemic preparedness.
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