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- ||| B-domain-deleted clotting factor VII (GNR-021) - XL / protein
Another few heavy legged miles in the bag tonight @alzheimerssoc #GNR2021 #manchestermarathon2021 https://t.co/opTagVgCDO (Twitter) - Jul 29, 2021
- | Kineret (anakinra) / SOBI, Affibody, PAS-IL-1Ra - XL / protein
Preclinical, Journal: PASylation of IL-1 Receptor antagonist (IL-1Ra) retains IL-1 blockade and extends its duration in mouse urate crystal-induced peritonitis. (Pubmed Central) - Sep 4, 2020
Surface plasmon resonance analyses revealed significant binding between PAS-IL‑1Ra and IL‑1R1, although with a slightly lower affinity than anakinra. These results validate PAS-IL‑1Ra as an active IL‑1 antagonist with marked in vivo potency and a significantly extended half-life compared with anakinra.
- | pasylated uricase (HZN-007) - XL / protein, Horizon Therapeutics
Journal: Computational Approach for Rational Design of Fusion Uricase with PAS Sequences. (Pubmed Central) - Aug 26, 2020
In this study, several variants of PASylated uricase from the Aspergillus flavus species were analyzed computationally to find the appropriate fusions to solve short half-life and stability concern...Molecular docking results showed that the highest binding affinity to uric acid belonged to uricase-PAS1-100 by the formation of six hydrogen and four non-hydrogen bonds. Altogether, the results indicated that the PASylation process would be promising upon the production of urate oxidase with improved solubility and stability.