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  • ||||||||||  Hepaton (thiazolidine) / SEDICO
    Journal:  Homozygous variants in WDR83OS lead to a neurodevelopmental disorder with hypercholanemia. (Pubmed Central) -  Nov 13, 2024   
    A zebrafish model lacking Wdr83os function further supports its role in the nervous system, craniofacial development, and lipid absorption. Taken together, our data support a disease-gene association between biallelic loss-of-function of WDR83OS and a neurological disease trait with hypercholanemia.
  • ||||||||||  Hepaton (thiazolidine) / SEDICO
    EXHALED BREATH ANALYSIS OF VOLATILE ORGANIC COMPOUNDS IS ASSOCIATED WITH LUMINAL DISEASE ACTIVITY IN PATIENTS WITH ULCERATIVE COLITIS (Ballroom B - Walter E. Washington Convention Center) -  Mar 14, 2024 - Abstract #DDW2024DDW_6742;    
    Conclusion VOC exhaled breath analysis shows a robust ability to discriminate patients with severe endoscopic disease from patients with minimal to no endoscopic inflammation. The differences in reported VOC point toward metabolic differences in bacterial fermentation, lipid and carbohydrate metabolism, and an increase in reactive oxygen species in patients with active disease.
  • ||||||||||  Hepaton (thiazolidine) / SEDICO
    Journal:  Stimulation of liver fibrosis by N2 neutrophils in Wilson's disease. (Pubmed Central) -  Oct 22, 2023   
    The facial eczema was allergic eczema caused by hepatic dysfunction and hepatonecrosis. Our findings provide a novel prospect that pharmacologic modulation of N2-neutrophil activity should be explored as an alternative therapeutic to improve liver function in Wilson's disease.
  • ||||||||||  Hepaton (thiazolidine) / Sedico
    Journal:  Moderate exercise relieves fluoride-induced liver and kidney inflammatory responses through the IKKβ/NFκB pathway. (Pubmed Central) -  Oct 27, 2022   
    In addition, the expression levels of IKKβ and NFκB were increased, and the expression of IκBα was decreased after fluoride exposure, indicating that fluoride activated the IKKβ/NFκB pathway. In summary, long-term moderate treadmill exercise relieved fluoride-induced liver and kidney inflammatory responses through the IKKβ/NFκB pathway, and exercise can be used to prevent fluoride-induced liver and kidney damage.
  • ||||||||||  Repretin (epoetin alfa biosimilar) / SEDICO, Rotapharm, Stivarga (regorafenib) / Bayer, Sutent (sunitinib) / Pfizer
    IDENTIFICATION OF NEW POTENTIAL DRUGGABLE TARGETS IN GASTROINTESTINAL STROMAL TUMOR (GIST) THROUGH RNA SEQUENCING ANALYSIS () -  Oct 19, 2022 - Abstract #AIOM2022AIOM_43;    
    Imatinib, a tyrosinekinase inhibitor is the standard treatment for GISTs; however, many patients develop resistance to this drug and to sunitinib, regorafenib and repretinib (used as second, third and fourth lines of treatment) and so identification of new potential pharmacological targets remains an unmet clinical need. TOP2A may represent a novel druggable target in GIST; further studies will be needed to better understand its role in the carcinogenesis process.
  • ||||||||||  Hepaton (thiazolidine) / Sedico
    Journal:  The new in the enteral dysbiosis correction intensified by heavy metals and mycotoxins. (Pubmed Central) -  May 14, 2022   
    The atmospheric methane emissions in the 2d group were decreased by 8 % (84±3.5 mg/m3). So, we can assume that using the complex of sorbents with hepatoprotective agent "Hepaton-vet" has a positive influence on the liver's metabolic process that has evidenced results of morpho-biochemical analysis and clinical diagnostic of animals.
  • ||||||||||  Hepaton (thiazolidine) / Sedico
    Journal:  The role of CGPR - receptor antagonist in the plastic process on the hepatopathies with toxical genesis. (Pubmed Central) -  May 14, 2022   
    So, we can assume that the CGPR - receptor antagonist drugs have a great variety in their administration, including the potentiation of other drugs used in the pharmacorrection of different pathologies. The balanced influence on the CGPR - receptors significantly influence the homeostasis maintenance and the nociception of the hepatobiliary system.
  • ||||||||||  Humira (adalimumab) / Eisai, AbbVie
    Journal:  Design and biological evaluation of novel long-acting adalimumab Fab conjugated with the albumin binding domain. (Pubmed Central) -  Nov 7, 2021   
    Most notably, the pharmacokinetics of Fab-ABDCon in mice was significantly improved with a 22-fold longer plasma half-life (28.2 h) compared with that of Fab control (1.31 h), which have contributed to its satisfactory therapeutic efficacy in murine TNFα-induced hepatonecrosis model. Thus, Fab-ABDCon could be a promising long-acting candidate suitable for drug development targeting TNFα-mediated inflammatory disease.
  • ||||||||||  povidone-iodine 7.5% / Sedico
    [VIRTUAL] Malignant pleural effusion: different treatments through countries () -  Jul 29, 2021 - Abstract #ERS2021ERS_3657;    
    Our study demonstrates that MP is effective and well tolerated in the majority of cases. This procedure may represent an interesting alternative to surgical thorascopy which is of a common use indeveloped countries.
  • ||||||||||  povidone-iodine 7.5% / Sedico
    Journal:  Removal of Aerosolized Contaminants from Working Canines via a Field Wipe-Down Procedure. (Pubmed Central) -  Jan 13, 2021   
    Reduction was similar between CHX or water in Labradors (p = 0.86) and shepherds (p = 0.06). Effective wipe-down strategies using common veterinary cleansers should be further investigated and incorporated into decontamination practices to safeguard working canine health and prevent cross-contamination of human personnel working with these animals.
  • ||||||||||  Hepaton (thiazolidine) / Sedico
    Preclinical, Journal:  Sub-chronic exposure to Kalach 360 SL-induced damage in rats' liver and hematological system. (Pubmed Central) -  Mar 3, 2020   
    Liver histological studies confirmed the presence of inflammatory reaction with pathology involving the damage or necrosis of hepatocytes, however, without fibrosis remodulation. Thus, KL sub-chronic exposure caused hepatonecrosis, systemic inflammation, and hemolysis.
  • ||||||||||  Hepaton (thiazolidine) / Sedico
    Journal:  The protective effects of modified palygorskite on the broilers fed a purified zearalenone-contaminated diet. (Pubmed Central) -  Nov 27, 2019   
    Dietary modified Pal supplementation reduced hepatic malondialdehyde accumulation, whereas increased renal superoxide dismutase activity in broilers fed a ZEN-contaminated diet at 42 d (P < 0.05). This finding suggested that dietary modified Pal administration could promote growth performance, reduce hepatonephric ZEN residues, and improve liver function and antioxidant status of broiler chickens receiving a ZEN-contaminated diet.
  • ||||||||||  Hepaton (thiazolidine) / Sedico
    Journal:  A hepatonephro-protective phenolic-rich extract from red onion (Allium cepa L.) peels. (Pubmed Central) -  Aug 8, 2019   
    The flavonol- and phenolic acid-based nature of constituents, the high phenolic content (72.33±5.30 mg gallic acid equivalent per one gram) and the significant antioxidant capacity (>1/3 potency of rutin) of ACPE may be thus attributed strongly to the hepatonephro-protective and anti-inflammatory effect of ACPE. The results suggest that red onion peels can serve as a convenient and cost-effective source of high-value antioxidant nutraceuticals for protection against oxidative stress-related disorders.