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- | Journal: Transcriptome Analysis Elucidates the Potential Key Genes Involved in Rib Development in bmp6-Deficient Silver Carp (Hypophthalmichthys molitrix). (Pubmed Central) - May 25, 2024
The up-regulated genes such as tnf?, fos, and ctgf in pathways may facilitate the proliferation and differentiation of osteoclasts, whereas the down-regulation of genes such as tgfb2 and tgfbr1 in pathways may hinder the formation and specialisation of osteoblasts, ultimately resulting in rib abnormalities. This study presents novel findings on the impact of bmp6 gene deletion on the rib development of silver carp, while simultaneously investigating the previously unexplored molecular mechanisms underlying rib defects in fish.
- | Journal: Tricetin suppresses the cell migration and BMP-6 expression through p38 signaling pathways in human retinal pigment epithelium cells. (Pubmed Central) - Apr 24, 2024
Moreover, blocking the p38 pathway also inhibits BMP-6 expression and migration in the ARPE-19 cells. In conclusion, this study revealed that tricetin inhibits the ARPE-19 cell migration mainly via the suppression of BMP-6 expression and p38 signaling pathway.
- | Journal: Bone morphogenetic protein-6 suppresses TGF-?2-induced epithelial-mesenchymal transition in retinal pigment epithelium. (Pubmed Central) - Apr 19, 2024
In conclusion, this study revealed that tricetin inhibits the ARPE-19 cell migration mainly via the suppression of BMP-6 expression and p38 signaling pathway. BMP-6 prevents the EMT in RPE cells induced by TGF-?2, which may provide a theoretical basis for the prevention and treatment of proliferative vitreoretinopathy.
- | Journal: Bone morphogenetic protein 6 (BMP6) antagonises experimental proliferative vitreoretinopathy established by TGF-?2 stimulation in retinal pigment epithelial cells through modulation of the p38 and JNK MAPK pathways. (Pubmed Central) - Apr 8, 2024
This is achieved through the regulation of the p38 and JNK MAPK pathways. These findings imply a potential connection between BMP6 and PVR, and highlight the potential application of BMP6 in therapeutic interventions for PVR.
- | Journal: BMP6 inhibits gastric cancer growth and predicts good prognosis. (Pubmed Central) - Mar 14, 2024
Our findings suggest that BMP6 is a potential prognostic biomarker in GC and can regulate the biological activity of GC cells through the NF-?B pathway. BMP6 may serve as a promising therapeutic target for GC, and our study introduces novel ideas for the prevention and treatment of this disease.
- | Journal: Regulation of iron metabolism in HEC-1A endometrium cells by macrophage-derived factors and fractalkine. (Pubmed Central) - Feb 27, 2024
FKN signaling may be involved in the management of iron trafficking of the endometrium by the regulation of hepcidin. It can contribute to the iron supply for fetal development at the early stage of the pregnancy.
- Bone Morphogenetic Protein 6 Deficiency Distorts Wnt and Oxidative Stress Signaling in Lung Tissue (San Diego Convention Center, Area B (Hall A-B2, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_6768;
Bmp6-/- mice exhibit a predicted reduction in pulmonary capillary endothelial cells, lower Wnt signaling pathway and pluripotency gene expression, and increased oxidative stress and redox pathway gene expression in both the air and CS exposed groups. These results extend our prior data, indicating a potential beneficial role for Bmp6 in lung repair.
- | Journal: Bone morphogenetic protein 6 induces downregulation of pentraxin 3 expression in human granulosa lutein cells in women with polycystic ovary syndrome. (Pubmed Central) - Jan 17, 2024
These results extend our prior data, indicating a potential beneficial role for Bmp6 in lung repair. The suppressive effect of BMP6 on PTX3 was mediated by ALK2/ALK3 type
- | cisplatin / Generic mfg.
Journal, Tumor mutational burden: TGF-?-regulated different iron metabolism processes in the development and cisplatin resistance of ovarian cancer. (Pubmed Central) - Jan 12, 2024
In conclusion, DIMP plays multifaceted roles in the initiation, chemo-resistance, and prognosis of ovarian cancer. Therapeutically targeting DIMP may pave the way for more tailored treatment approaches for ovarian cancer.
- | Journal: Calcium phosphate ceramics combined with rhBMP6 within autologous blood coagulum promote posterolateral lumbar fusion in sheep. (Pubmed Central) - Dec 17, 2023
Biomechanical testing confirmed that fusion between transverse processes was complete and successful. Osteogrow-C implants induced spinal fusion in sheep PLF model and therefore represent a novel therapeutic solution for patients with degenerative disc disease.
- | GYY4137 / National University of Singapore
Journal: An H S-BMP6 Dual-Loading System with Regulating YAP/TAZ and Jun Pathway for Synergistic Critical Limb Ischemia Salvaging Therapy. (Pubmed Central) - Nov 13, 2023
Meanwhile, laser-doppler perfusion imaging (LDPI), injury severity evaluation, and histological analysis confirm the excellent therapeutic effects of UIO-66-NH @GYY4137@BMP6 in vivo. This work may shed light on the treatment of critical limb ischemia by regulating YAP, Jun, and p53 signaling pathways based on gas-protein synergistic therapy.
- | Journal: BMP6 participates in the pathogenesis of adolescent idiopathic scoliosis by regulating osteopenia. (Pubmed Central) - Oct 5, 2023
Simultaneously, knockout of BMP6 in zebrafish embryos significantly increased the deformity rate. The findings of this study suggest that BMP6 is a key gene that regulates the abnormal osteogenic differentiation of BMSCs in AIS via the CAP1-217/BMP6/RUNX2 axis.
- | Journal: Clinical Significance of Erythroferrone and Bone Morphogenetic Protein-6 in Patients with Anemia in the Course of Inflammatory Bowel Disease. (Pubmed Central) - Sep 27, 2023
In conclusion, we confirm an increase in erythroferrone concentration in the entire group of IBD patients with anemia, while BMP-6 levels were higher only in anemic CD patients. Due to the clinical importance of anemia in IBD, this problem is worth further analysis and research projects.
- | Journal: Naotaifang formula attenuates OGD/R-induced inflammation and ferroptosis by regulating microglial M1/M2 polarization through BMP6/SMADs signaling pathway. (Pubmed Central) - Sep 16, 2023
The BMP6/SMADs signaling pathway is a potential therapeutical target of inflammation and ferroptosis induced by the transformation of microglia. Moreover, NTF could alleviate inflammation and ferroptosis through the BMP6/SMADs signaling pathway in OGD/R-injured microglia.
- | Journal, Stroma: Effect of milk and whey on proliferation and differentiation of placental stromal cells. (Pubmed Central) - Sep 1, 2023
Moreover, NTF could alleviate inflammation and ferroptosis through the BMP6/SMADs signaling pathway in OGD/R-injured microglia. As expected, PPRG expression also increased with adipogenic stimulation.
- | Journal: Role of hepcidin upregulation and proteolytic cleavage of ferroportin 1 in hepatitis C virus-induced iron accumulation. (Pubmed Central) - Aug 16, 2023
The other is post-translational regulation of the iron-exporting membrane protein ferroportin 1 (FPN1), which is cleaved between residues Cys284 and Ala285 in the intracytoplasmic loop region of the central portion mediated by HCV NS3-4A serine protease. We propose that host transcriptional activation triggered by endoplasmic reticulum stress and FPN1 cleavage by viral protease work in concert to impair iron efflux, leading to iron accumulation in HCV-infected cells.
- | Journal: Differential Modulation of miR-122 Transcription by TGF?1/BMP6: Implications for Nonresolving Inflammation and Hepatocarcinogenesis. (Pubmed Central) - Aug 15, 2023
Furthermore, we presented convincing evidence directly linking reduced miR-122 transcription to inflammation and in chronic liver diseases. The results of this study strongly suggest that prolonged activation of pro-inflammatory signaling pathways, leading to disruption of cytokine-mediated regulation of miR-122, may significantly contribute to the onset and exacerbation of chronic liver disease.
- | Journal: Decrease levels of bone morphogenetic protein 6 and noggin in chronic schizophrenia elderly. (Pubmed Central) - Jun 2, 2023
APOE ?4 carriers had lower levels of BMP6 than APOE non-?4 carriers under chronic SCZ. There was a significant relationship of blood BMP6/noggin with cognitive performance in chronic SCZ.
- | Journal: Extracellular matrix composition analysis of human articular cartilage for the development of organ-on-a-chip. (Pubmed Central) - May 20, 2023
The standardized de-cellularization process could preserve majority of ECM components, providing structural integrity and architecture to the ECM. The Identified proteins quantified for their expression levels provided insight into engineering the ECM composition for developing cartilage-on-a-chip.
- | Journal: The serum levels of activin A and bone morphogenetic protein-4 and -6 in patients with fibrodysplasia ossificans progressiva. (Pubmed Central) - May 15, 2023
There were no significant differences in the serum levels of activin A, BMP4 and BMP6 in FOP patients compared with healthy control subjects. Serum activin A, BMP4 and BMP6 proteins might not be the stimulators for FOP flare-up, and may not be biomarkers for FOP diagnosis.
- Reblozyl (luspatercept-aamt) / BMS, Merck (MSD)
TMPRSS6 INHIBITION WITH A MONOCLONAL ANTIBODY IMPROVES RED BLOOD CELL HEALTH AND IRON OVERLOAD IN A MOUSE MODEL OF BETA-THALASSEMIA (Panorama 1) - May 12, 2023 - Abstract #EHA2023EHA_2344;
These therapeutics only target either RBC formation (luspatercept) or iron loading (iron chelators), but not both. Our results indicate that inhibition of TMPRSS6 may be a good addition to current therapeutic options for iron overload diseases such as beta-thalassemia, as it significantly reduces liver iron loading and significantly improves RBC health.
- | doxorubicin hydrochloride / Generic mfg.
Journal: Gibberellin derivative GA-13315 overcomes multidrug resistance in breast cancer by up-regulating BMP6 expression. (Pubmed Central) - Dec 20, 2022
Either overexpression of BMP6 or treatment the cells with GA5 significantly decreased ERK phosphorylation and P-gp expression, indicating that GA5 reversed MDR of MCF-7/Adr cells by upregulating BMP6, thereby inhibiting the activation of ERK signaling pathway and reducing P-gp expression. Collectively, our present study demonstrated that the MDR of MCF-7/Adr cells was closely related to the low expression of BMP6, and revealed the molecular mechanisms by which GA5 overcame MDR in breast cancer, providing evidence in supporting the development of GA5 to be a promising agent for overcoming MDR in clinical cancer therapy in the future.
- | Journal: BMP6 regulates AMH expression via SMAD1/5/8 in goat ovarian granulosa cells. (Pubmed Central) - Dec 18, 2022
Interestingly, the activation of SMAD1/5/8 alone did not affect the expression of AMH or GATA4. The results suggested that BMP6 upregulated GATA4 through the SMAD1/5/8 signaling pathway, which in turn promoted AMH expression.
- | Journal: Site pleiotropy of a stickleback Bmp6 enhancer. (Pubmed Central) - Nov 10, 2022
Transgenic analysis and site-directed mutagenesis experiments both deleting and scrambling this predicted Foxc1 TFBS revealed that the binding site is required for enhancer activity in both teeth and fins throughout embryonic, larval, and adult development, and in the heart and kidney in adult fish. Collectively these data support a model where the pleiotropy of this Bmp6 enhancer is due to site pleiotropy and this putative binding site is required for enhancer activity in multiple anatomical sites from the embryo to the adult.
- | Journal: Liver sinusoidal endothelial cells induce BMP6 expression in response to non-transferrin bound iron. (Pubmed Central) - Nov 10, 2022
Our data suggest that during systemic iron overload, LSECs internalize NTBI, which promotes oxidative stress and thereby transcriptionally induces Bmp6 via Nrf2. Tfr1 appears to contribute to iron sensing by LSECs mostly under low iron conditions.
- | Journal: Anticeramide Improves Sjögren's Syndrome by Blocking BMP6-Induced Th1. (Pubmed Central) - Oct 26, 2022
Moreover, an in vivo study showed that anticeramide treatment (myriocin) for an SS animal model (NOD/LtJ mice) could significantly decrease the IFN-γ expression and Th1 frequency in the salivary glands and suppress the inflammation infiltration in salivary glands and maintain the salivary flow rates, both of which reflect SS-like symptoms. This study identifies a promising target that could effectively attenuate the abnormal state of CD4 T cells and reverse the progression of SS.
- LIVER SINUSOIDAL ENDOTHELIAL CELLS INDUCE BMP6 EXPRESSION IN RESPONSE TO NON-TRANSFERRIN BOUND IRON () - Oct 23, 2022 - Abstract #AASLD2022AASLD_1764;
During systemic iron overload, LSECs internalize NTBI, which promotes oxidative stress and thereby transcriptionally induces Bmp6 via Nrf2. The contribution of Tfr1 and transferrin-bound iron to Bmp6 induction is minimal.
- | Journal: Comparison of synthetic ceramic products formulated with autologous blood coagulum containing rhBMP6 for induction of bone formation. (Pubmed Central) - Oct 15, 2022
The contribution of Tfr1 and transferrin-bound iron to Bmp6 induction is minimal. Osteogrow-C bone regenerative device was effective with a broad range of commercially available synthetic ceramics providing a promising therapeutic solution for the regeneration of long bone fracture nonunion, large segmental defects, and spinal fusion surgeries.
- | Journal: Foxp1 and Foxp4 deletion causes the loss of follicle stem cell niche and cyclic hair shedding by inducing inner bulge cell apoptosis. (Pubmed Central) - Sep 29, 2022
In addition, the double KO of Foxp1/4 induced the apoptosis of K6-positive (K6+) inner bulge cells, a well-established stem cell (SC) niche, thus resulting in the destruction of the bulge SC niche and recurrent hair loss. Our investigation reveals the synergistic role of Foxp1/4 in sustaining K6+ niche cells for the quiescence of HFSCs.
- | progesterone / Generic mfg.
Journal, IO biomarker: BMP6 Promotes the Secretion of 17 Beta-Estradiol and Progesterone in Goat Ovarian Granulosa Cells. (Pubmed Central) - Aug 27, 2022
Further studies found that BMP6 inhibited the mRNA expression of 3β-HSD and steroid synthesis acute regulator (StAR) but significantly promoted the mRNA expression of the E2 synthesis rate-limiting enzyme CYP19A1 and the P4 synthesis rate-limiting enzyme CYP11A1 (p < 0.01). Taken together, these results showed that the exogenous addition of BMP6 did not affect the proliferation, cell cycle, and apoptosis of goat ovarian GCs but promoted the secretion of E2 and progesterone P4 in ovarian GCs by upregulating the mRNA expressions of CYP19A1 and CYP11A1.
- | Journal: Enzootic bovine leukosis in a 21-month-old Japanese Black cow with high susceptibility. (Pubmed Central) - Jul 9, 2022
The cow was definitively diagnosed with EBL based on these findings. Infection with a highly pathogenic strain of BLV, susceptibility of the BoLA-DRB3 alleles, and hypermethylation of the BMP6 gene may have contributed to the development of EBL in our case.
- | Journal: LncXIST Facilitates Iron Overload and Iron Overload-Induced Islet Beta Cell Injury in Type 2 Diabetes through miR-130a-3p/ALK2 Axis. (Pubmed Central) - Jun 22, 2022
Moreover, knockdown of ALK2 alleviated iron overload and iron overload-induced INS-1 cells injury by inhibiting bone morphogenetic protein 6 (BMP6)/ALK2/SMAD1/5/8 axis but reversed with XIST upregulation, which was terminally boosted by overexpression of miR-130a-3p. XIST has the capacity to promote iron overload and iron overload-related T2D initiation and development through inhibition of ALK2 expression by sponging miR-130a-3p, and that targeting this axis may be an effective strategy for treating patients with T2D.
- | Journal: Iron, hepcidin, and microcytosis in canine hepatocellular carcinoma. (Pubmed Central) - Jun 8, 2022
Microcytic cases had higher hepcidin RNA in non-HCC tissue than normocytic cases. Future studies may extend these findings to protein quantification, cellular localization of RNA changes, and determining if iron loading in canine liver is a predisposing factor for HCC.
- || Review, Journal: Polymorphisms and avascular necrosis in patients with sickle cell disease - A systematic review. (Pubmed Central) - May 26, 2022
The results indicate that the polymorphisms in BMP6, Klotho and ANXA2 genes may be associated with avascular necrosis in patients with sickle cell disease. However, in order to confirm these genetic changes as risk factors, further studies with greater statistical power and methodological rigor are needed.
- | Journal: Role of the BMP6 protein in breast cancer and other types of cancer. (Pubmed Central) - May 19, 2022
This work presents a review on the role of BMP6 protein in breast cancer (BC) and other types of cancer. The studies carried out to date suggest the participation of the BMP6 protein in the epithelial-mesenchymal transition (EMT) phenotype, cell growth and proliferation; however, these processes are affected in a variable way in the different types of cancer, the methylated CpG sites in BMP6 gene promoter, as well as the interaction with other proteins could be the cause of such variation.
- Cytochrome P450 1B1 regulates ocular oxidative stress through modulation of iron homeostasis by retinal endothelial cells ([Virtual]) - Apr 29, 2022 - Abstract #ARVO2022ARVO_2113;
Our findings establish that CYP1B1 expression maintains ocular redox homeostasis through estrogen receptor signaling impacting iron homeostasis by modulation of BMP6 levels in the endothelium. Lack of Cyp1b1 results in increased intracellular iron levels, enhanced lipid peroxidation, and oxidative stress.
- || Clinical, Journal: Additional Burden of Iron Deficiency in Heart Failure Patients beyond the Cardio-Renal-Anaemia Syndrome: Findings from the BIOSTAT-CHF Study. (Pubmed Central) - Apr 2, 2022
ID, CKD and/or anaemia in patients with HF have great overlap in biomarker profiles, suggesting common pathways associated with these syndromes. ID either alone or on top of CKD and anaemia is associated with worse quality of life, exercise capacity and prognosis of patients with worsening HF.
- Targeting bone morphogenetic protein 6 as a therapeutic target for LKB1-inactivated lung cancer (Section 20) - Mar 9, 2022 - Abstract #AACR2022AACR_3329;
Collectively, our findings show that upregulation of hepcidin via BMP6 signaling and followed by iron sequestration in tumor cells is part of the metastatic invasion strategy of LKB1 inactivated NSCLC. Therefore, current clinical strategies targeting BMP6 signaling could improve outcomes for LKB1-mutant lung cancer patients.
- | Journal: Evolved Bmp6 enhancer alleles drive spatial shifts in gene expression during tooth development in sticklebacks. (Pubmed Central) - Feb 17, 2022
Comparing Bmp6 expression by in situ hybridization in developing teeth of marine and freshwater fish reveals similar evolved spatial shifts in gene expression. Together, these data support a model in which the polymorphisms within this enhancer underlie evolved tooth gain by shifting the spatial expression of Bmp6 during tooth development, and provide a general strategy to identify spatial differences in enhancer activity in vivo.
- | Preclinical, Journal: Bone morphogenetic protein 6-mediated crosstalk between endothelial cells and hepatocytes recapitulates the iron sensing pathway in vitro. (Pubmed Central) - Feb 15, 2022
In addition, EC-derived BMP6 and hepcidin were highly sensitive to not only levels of ferric iron, but also heme as low as 500 nM. We here establish a hepatocyte-endothelial co-culture system to fully recapitulate iron regulation by hepcidin using EC-derived BMP6.
- Role of bone morphogenetic protein 6 in hepatocellular carcinoma ([VIRTUAL]) - Jan 28, 2022 - Abstract #FALKALD2022FALK_ALD_65;
- | dorsomorphin (Compound C) / EMD Serono
Journal: BMP6 increases CD68 expression by up-regulating CTGF expression in human granulosa-lutein cells. (Pubmed Central) - Jan 21, 2022
Using BMP type I receptor inhibitors (dorsomorphin, DMH-1 and SB431542), we demonstrated that both activin receptor-like kinase (ALK)2 and ALK3 are involved in BMP6-induced stimulatory effects on the expression of CTGF and CD68...Moreover, CTGF-knock down abolished the BMP6-induced up-regulation of CD68 expression. These findings indicate that intrafollicular CTGF mediates BMP6-induced increases in CD68 expression through the ALK2/ALK3-mediated SMAD-dependent signaling pathway.
- | Biomarker, Journal: Bone morphogenetic protein 6 expression in cumulus cells is negatively associated with oocyte maturation. (Pubmed Central) - Jan 18, 2022
In conclusion, BMP6 was mainly expressed in oocytes at all human follicular developmental stages and BMP6 mRNA expression in CCs may be negatively correlated with oocyte maturation. BMP6 expression could therefore be used as a biomarker of oocyte maturation.
- | Preclinical, Journal: The decellularized ovary as a potential scaffold for maturation of preantral ovarian follicles of prepubertal mice. (Pubmed Central) - Jan 18, 2022
BMP6 expression could therefore be used as a biomarker of oocyte maturation. GAG: glycosaminoglycan; ECM: extracellular matrix; 2D: two-dimensional; E2: estradiol; P4: progesterone; BMP15: bone morphogenetic protein 15; GDF9: growth differentiation factor 9; ZP2: zona pellucida 2; Gdf9: growth/differentiation factor-9; Bmp6: bone morphogenetic protein 6; Bmp15: bone morphogenetic protein 15.
- | flutamide / Generic mfg.
Journal: Regulatory role of dihydrotestosterone on BMP-6 receptors in granular cells of sheep antral follicles. (Pubmed Central) - Jan 6, 2022
We further explored whether DHT regulates ALK-6 and BMPRII through the nuclear androgen receptor (AR) pathway and found that 10-M flutamide, a non-selective androgen inhibitor, partially relieved the inhibitory effect of 10M DHT on ALK-6 and BMPRII expression...The present study aimed to determine the expression of the main BMP-6-related main receptors, namely, ALK-6 and BMPRII, during the development of GCs in sheep antral follicles and a potential mechanism of DHT regulation in sheep GCs. Our findings lay a foundation for the further exploration of the effects of ovarian BMP-6 expression on follicular development.
- | Desferal (deferoxamine) / Kermanshah University of Medical Sciences, Novartis
Journal: Direct modulation of hepatocyte hepcidin signaling by iron. (Pubmed Central) - Nov 22, 2021
Iron directly blocks hepatocellular hepcidin signaling through the BMP/SMAD pathway but independent of STAT3. This mechanism may contribute to continued iron overload in many pathophysiological conditions ultimately causing a vicious cycle of continued hepcidin suppression.
- | Journal: Iron overload inhibits BMP/SMAD and IL-6/STAT3 signaling to hepcidin in cultured hepatocytes. (Pubmed Central) - Nov 17, 2021
These responses were accompanied by induction of GCLC and HMOX1 mRNAs, known markers of oxidative stress. We conclude that hepatocellular iron overload suppresses hepcidin by inhibiting the SMAD and STAT3 signaling pathways downstream of their respective ligands.
- | Journal: BMP-6 Attenuates Oxygen and Glucose Deprivation-Induced Apoptosis in Human Neural Stem Cells through Inhibiting p38 MAPK Signaling Pathway. (Pubmed Central) - Oct 31, 2021
These results indicated that blocking the phosphorylation of p38 might contribute to the neuroprotective effect of BMP-6 against the OGD-induced injury in hNSCs. These findings suggested that BMP-6 might be a therapeutic target in the OGD-induced cell death, which provides a novel therapeutic strategy for enhancing host and graft NSCs survival in hypoxic-ischemic brain injury.
- | Journal: Macrophage-derived oncostatin M/bone morphogenetic protein 6 in response to Mg-based materials influences pro-osteogenic activity of human umbilical cord perivascular cells. (Pubmed Central) - Oct 27, 2021
Besides, both materials could reduce the secretion of tumour necrosis factor alpha (TNFα) and interleukin 1 beta (IL1β) in macrophages and cocultures. These results collectively imply that Mg and Mg-10Gd could create a beneficial microenvironment for osteogenic differentiation and further support Mg-based biomaterial immunomodulatory properties by modulating the interactions of macrophages and MSC for bone regeneration.
- | Journal: Hepcidin-regulating iron metabolism genes and pancreatic ductal adenocarcinoma: a pathway analysis of genome-wide association studies. (Pubmed Central) - Oct 27, 2021
Our results support that genetic susceptibility related to the hepcidin-regulating gene pathway is associated with PDAC risk and suggest a potential role of iron metabolism in pancreatic carcinogenesis. Further studies are needed to evaluate effect modification by intake of iron-rich foods on this association.